@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1513: (2016-03-26 )
MNKLVLIDGNSLSFRAFYALPLLSNKAGIHTNAVYGFAMLLEKILKEEKPNHFLVAFDAGKTTFRHEKYSEYKGGRQKTPPELSEQFPYIRQLLDAYHIKRYELDNYEADDIIGTLSKEADKAGFQTIIITGDRDLTQLATDNVTIYYTKKGVTDVDHYTPDFIAEKYNGLTPNQIIDMKGLMGDTSDNIPGVAGVGEKTAIKLLNQFDTVEGVYEHLDEISGKKLKEKLQNSKEDALMSKELATINVDSPIEVKLEDTLMTHQDEQQEKIELFKKLEFKQLLSDIDQSASVEDAIEKTFEIETSFDNIDFTSLKEAAIHFELDGGNYLRNNILKFSLFTGEKHIVINADDINNYAELVSWLENPNTKKVVYDAKKTYVASHRLGIDIQNISFDIMLASYIIDPSRTISDVQSVVSLYGQSFVKDDVSIYGKGKKFKVPEDDVLNPYVASITDAIYFAKPNMDKQLEEYNQVELLADLELPLAKILSEMEEIGIFTDVHDLEEMEKEIQEKLDVLIRNIHDAAGEDFNINSPKQLGVVLFETLQLPVIKKTKTGYSTAVDVLEQLQGEHPIIDYILEYRQLSKLQSTYVEGLQKVISDDQRIHTRFNQTLAQTGRLSSVDPNLQNIPVRLEEGRKIRKAFKPTSKDSVILSADYSQIELRVLAHITQDESMKEAFINGDDIHTATAMKVFGVEADQVDSLMRRQAKAVNFGIVYGISDYGLSQSLGITRKKAKAFIDDYLASFPGVKQYMSDIVKDAKALGYVETLLHRRRYIPDITSRNFNLRGFAERTAMNTPIQGSAADIIKLAMVKFAQKMKETTYQAKLLLQVHDELIFEVPKSEVDSFSEFVEEIMENALQLDVPLKVDSSYGATWYDAK
Atome Classification :
(101 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.....-..430.......440.......450....-...-460.....-..470.......480.......490.......500.......510.......520.......530.......540.......550...-.....560.......570.......580.......590......-.-----600........610.......620....---...630..------....----.640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810......-.820.-------------------......830.......840.......850...-------....860.......870....----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
K
L
V
L
I
DGNS
L
S
F
R
A
F
Y
A
LPLLSNKAGIH
T
N
A
V
Y
G
F
A
M
L
L
E
K
I
L
K
EEKPN
H
F
L
V
A
FDAGK
T
T
FRH
E
K
Y
S
E
YKGGRQKT
P
P
E
L
S
E
Q
F
P
Y
I
R
Q
L
L
D
A
Y
H
I
K
R
Y
ELDNY
E
A
D
D
I
I
G
T
L
S
K
E
A
DKAG
F
Q
T
I
I
I
TGDR
D
L
T
Q
LATD
N
V
T
I
Y
Y
TKKGVTDVDHY
T
P
D
F
I
A
E
K
YNGLTPN
Q
I
I
DMKGLMGDTSDNIPGVAGV
G
E
K
T
A
I
K
L
L
N
QF
D
T
V
E
G
V
Y
E
H
L
D
E
IS
G
K
K
L
K
E
K
L
QNS
K
E
D
A
L
MSK
E
L
A
T
I
NVDS
P
I
E
V
K
L
E
D
T
LMTH
Q
D
E
Q
Q
E
K
I
E
L
F
K
K
L
E
F
K
Q
L
L
S
D
I
DQSA
S
V
E
D
A
I
E
K
T
F
E
I
ETSFDNI
D
F
T
SLK
E
A
A
I
H
F
E
LDGG
N
Y
L
R
NN
I
L
K
F
S
LFTGE
K
H
I
V
I
N
A
D
D
I
N
N
Y
A
E
L
V
S
W
L
ENPNT
K
K
V
V
YDA
K
K
T
Y
V
AS
H
R
L
G
I
D
I
QN
I
S
F
D
I
M
L
A
S
Y
IIDP
S
R
T
I
S
D
V
Q
S
V
V
S
L
Y
G
Q
S
F
V
K
D
D
V
-
S
I
YGKGKKFKVPEDDVL
N
P
Y
V
A
S
IT
D
A
I
Y
-FAK-P
N
M
D
K
Q
L
E
-
E
Y
N
Q
V
E
L
L
A
DLE
L
P
L
A
K
I
L
S
E
M
E
EIGIFTD
V
H
D
L
E
E
M
E
K
E
I
Q
E
K
L
D
V
L
I
R
N
I
H
DAAGEDFNIN
S
P
K
Q
L
G
V
V
L
F
E
TLQLP
V
I
KKT-KTG-Y
S
T
A
V
D
V
L
E
Q
LQGEH
P
I
I
D
Y
I
L
E
Y
R
Q
L
S
K
L
Q
S
T
Y
V
E
G
L
Q
K
V
ISD-
D
-----
Q
-
R
I
H
T
R
F
N
Q
T
L
A
QTGRLSSVDPNLQNI---
P
V
R
L
E
E
G
R
------
K
I
R
K
----
A
FKPTSKD
S
V
I
L
SADYS
Q
I
E
L
R
V
L
A
H
ITQ
D
E
S
M
K
E
AFINGDDI
H
T
A
T
A
M
K
V
FGV
E
A
D
Q
V
D
S
L
M
R
R
Q
A
KAV
N
F
G
I
V
Y
GISDYGLSQSLGI
T
R
K
K
A
K
A
F
I
D
D
Y
L
A
SFP
G
V
K
Q
Y
M
S
D
I
V
K
D
A
K
A
L
G
Y
V
E
T
L
L
H
RRRYIPDITSRNFNLRGF
A
E
R
TAMNTPIQG
S
A
A
D
I
I
K
L
A
M
V
K
F
A
Q
K
M
K
E
T
-
T
Y
Q
A
K
-------------------
L
L
L
Q
V
H
D
E
L
I
F
EV
P
K
S
E
V
D
S
F
S
E
F
V
E
E
I
M
E
N
A
-------LQLDV
P
L
K
VDSSYGATWYDAK----
42
PsiBlast_CBE
90.03
54%
-95
- C4 -
1U4B
7
DPO1_GEOSE
A:
[19-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
44
PsiBlast_CBE
89.92
54%
-95
- C4 -
1U48
7
DPO1_GEOSE
A:
[19-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
43
PsiBlast_CBE
89.60
54%
-94
- C4 -
1U49
7
DPO1_GEOSE
A:
[19-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
61
PsiBlast_CBE
89.59
53%
-96
- C4 -
2Y1J
4
?
A:
[19-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
S
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
K
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
R
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
77
PsiBlast_CBE
89.57
53%
-95
- C4 -
4F2R
7
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
46
PsiBlast_CBE
89.45
54%
-94
- C4 -
1U45
7
DPO1_GEOSE
A:
[19-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
21
PsiBlast_CBE
89.30
54%
-94
- C4 -
1LV5
6
DPO1_GEOSE
B:
[19-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
A
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
76
PsiBlast_CBE
89.29
53%
-94
- C4 -
4F2S
6
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
40
PsiBlast_CBE
89.26
54%
-94
- C4 -
1UA1
6
DPO1_GEOSE
A:
[19-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
45
PsiBlast_CBE
89.25
54%
-94
- C4 -
1U47
7
DPO1_GEOSE
A:
[19-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
62
PsiBlast_CBE
89.20
53%
-97
- C4 -
2Y1I
4
?
A:
[19-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
S
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
K
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
R
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
90
PsiBlast_CBE
88.96
53%
-94
- C4 -
4DQR
7
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
A
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
41
PsiBlast_CBE
88.92
54%
-93
- C4 -
1UA0
6
?
A:
[19-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
48
PsiBlast_CBE
88.81
53%
-97
- C4 -
2XY7
5
?
A:
[19-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
A
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
R
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
91
PsiBlast_CBE
88.79
53%
-95
- C4 -
4DQQ
7
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
A
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
79
PsiBlast_CBE
88.45
53%
-94
- C4 -
4EZ6
4
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
65
PsiBlast_CBE
88.45
53%
-96
- C4 -
4DQP
5
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
83
PsiBlast_CBE
88.43
53%
-93
- C4 -
3THV
6
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
4
PsiBlast_PDB
88.43
54%
-95
- C4 -
1LV5
7
DPO1_GEOSE
A:
[19-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
A
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
78
PsiBlast_CBE
88.38
53%
-95
- C4 -
4EZ9
4
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
87
PsiBlast_CBE
88.36
53%
-93
- C4 -
3PV8
6
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
74
PsiBlast_CBE
88.30
53%
-94
- C4 -
4F4K
7
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
75
PsiBlast_CBE
88.21
53%
-95
- C4 -
4F3O
5
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
82
PsiBlast_CBE
88.18
53%
-93
- C4 -
3TI0
5
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
81
PsiBlast_CBE
88.13
53%
-95
- C4 -
4DSE
6
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
80
PsiBlast_CBE
88.10
53%
-95
- C4 -
4DSF
6
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
85
PsiBlast_CBE
88.01
53%
-95
- C4 -
3PX4
6
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
66
PsiBlast_CBE
87.90
53%
-93
- C4 -
4DQI
5
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
86
PsiBlast_CBE
87.74
53%
-93
- C4 -
3PX0
5
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
84
PsiBlast_CBE
87.59
53%
-92
- C4 -
3PX6
6
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
27
PsiBlast_CBE
87.38
57%
-95
- C4 -
1NK9
7
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
8
PsiBlast_PDB
87.32
57%
-93
- C4 -
2HHU
9
?
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
24
PsiBlast_CBE
87.30
57%
-94
- C4 -
1NKE
10
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
16
PsiBlast_PDB
87.19
57%
-95
- C4 -
1L5U
7
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
7
PsiBlast_PDB
87.17
57%
-94
- C4 -
2HHT
9
?
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
12
PsiBlast_PDB
87.12
57%
-94
- C4 -
1L3S
9
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
1
PsiBlast_PDB
87.11
57%
-93
- C4 -
3BDP
4
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
R
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
34
PsiBlast_CBE
87.10
57%
-94
- C4 -
4DWI
10
?
A:
[61-581]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
26
PsiBlast_CBE
87.07
57%
-94
- C4 -
1NKB
7
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
20
PsiBlast_PDB
87.07
57%
-93
- C4 -
1NJZ
8
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
9
PsiBlast_PDB
87.06
57%
-93
- C4 -
2HHV
9
?
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
19
PsiBlast_PDB
87.02
57%
-94
- C4 -
1NJY
7
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
10
PsiBlast_PDB
86.96
57%
-96
- C4 -
2HHX
7
DPO1_BACCA
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
------
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
11
PsiBlast_PDB
86.94
57%
-95
- C4 -
2HW3
8
?
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
14
PsiBlast_PDB
86.92
57%
-93
- C4 -
1L3U
7
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
3
PsiBlast_PDB
86.88
57%
-95
- C4 -
2BDP
5
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
R
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
15
PsiBlast_PDB
86.82
57%
-93
- C4 -
1L3V
7
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
35
PsiBlast_CBE
86.80
57%
-95
- C4 -
4DSI
10
?
A:
[61-581]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
59
PsiBlast_CBE
86.78
57%
-95
- C4 -
3EYZ
5
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
25
PsiBlast_CBE
86.77
57%
-92
- C4 -
1NKC
6
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
47
PsiBlast_CBE
86.67
57%
-95
- C4 -
4O0I
8
?
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
30
PsiBlast_CBE
86.65
57%
-93
- C4 -
1NK6
6
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
6
PsiBlast_PDB
86.63
57%
-91
- C4 -
2HHS
7
?
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
13
PsiBlast_PDB
86.60
57%
-93
- C4 -
1L3T
7
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
37
PsiBlast_CBE
86.59
57%
-98
- C4 -
4DSK
6
?
A:
[59-579]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
-----
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
33
PsiBlast_CBE
86.52
57%
-90
- C4 -
1NK0
7
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
31
PsiBlast_CBE
86.52
57%
-93
- C4 -
1NK5
6
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
28
PsiBlast_CBE
86.51
57%
-93
- C4 -
1NK8
8
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
29
PsiBlast_CBE
86.46
57%
-93
- C4 -
1NK7
8
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
32
PsiBlast_CBE
86.45
57%
-91
- C4 -
1NK4
7
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
2
PsiBlast_PDB
86.38
57%
-93
- C4 -
4BDP
5
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
R
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
60
PsiBlast_CBE
86.29
56%
-96
- C4 -
2XY6
6
?
A:
[61-581]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
R
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
57
PsiBlast_CBE
86.27
56%
-96
- C4 -
4UQG
7
?
A:
[59-579]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
R
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
17
PsiBlast_PDB
86.26
57%
-91
- C4 -
1NJW
7
?
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
55
PsiBlast_CBE
86.20
56%
-93
- C4 -
4B9L
7
?
A:
[99-619]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
R
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
5
PsiBlast_PDB
86.19
57%
-92
- C4 -
2HHQ
8
?
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
18
PsiBlast_PDB
86.15
57%
-91
- C4 -
1NJX
8
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
50
PsiBlast_CBE
86.10
56%
-93
- C4 -
4B9U
8
?
A:
[99-619]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
R
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
92
PsiBlast_CBE
86.07
56%
-91
- C4 -
3HT3
6
?
D:
[59-579]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
P
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
67
PsiBlast_CBE
86.05
56%
-92
- C4 -
3EZ5
7
DPO1_GEOSE
D:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
63
PsiBlast_CBE
86.03
53%
-95
- C4 -
4DS5
4
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
--------------------
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
23
PsiBlast_CBE
86.02
57%
-92
- C4 -
1XC9
7
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
49
PsiBlast_CBE
85.81
56%
-94
- C4 -
4B9V
9
?
A:
[99-619]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
R
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
52
PsiBlast_CBE
85.80
56%
-92
- C4 -
4B9S
9
?
A:
[99-619]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
R
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
64
PsiBlast_CBE
85.73
53%
-94
- C4 -
4DS4
4
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
--------------------
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
56
PsiBlast_CBE
85.72
56%
-93
- C4 -
2XY5
8
?
A:
[61-581]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
R
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
53
PsiBlast_CBE
85.70
56%
-91
- C4 -
4B9N
9
?
A:
[99-619]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
R
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
54
PsiBlast_CBE
85.60
56%
-90
- C4 -
4B9M
8
?
A:
[99-619]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
R
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
93
PsiBlast_CBE
85.59
56%
-95
* C4 *
3HT3
5
?
A:
[59-579]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
P
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
51
PsiBlast_CBE
85.59
56%
-94
- C4 -
4B9T
5
?
A:
[99-619]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
R
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
39
PsiBlast_CBE
85.48
57%
-94
- C4 -
4DSJ
4
?
A:
[59-579]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
73
PsiBlast_CBE
85.46
53%
-95
- C4 -
4F8R
3
?
D:
[31-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
--------------------------
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
88
PsiBlast_CBE
85.45
56%
-92
- C4 -
2HHW
5
?
D:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
58
PsiBlast_CBE
85.40
56%
-96
- C4 -
2XO7
6
?
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
R
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
68
PsiBlast_CBE
85.37
56%
-92
- C4 -
3EZ5
7
DPO1_GEOSE
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
89
PsiBlast_CBE
85.32
56%
-92
- C4 -
2HHW
5
?
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
72
PsiBlast_CBE
85.30
56%
-96
- C4 -
2HVH
7
?
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
70
PsiBlast_CBE
85.28
56%
-91
- C4 -
2HVI
6
?
A:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
69
PsiBlast_CBE
85.25
56%
-91
- C4 -
2HVI
5
?
D:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
71
PsiBlast_CBE
85.12
56%
-93
- C4 -
2HVH
7
?
D:
[60-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
-----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
36
PsiBlast_CBE
85.03
57%
-92
- C4 -
4DSL
3
?
A:
[59-579]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
38
PsiBlast_CBE
83.32
57%
-93
- C4 -
4DSJ
2
?
B:
[59-579]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
-
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
-
P
F
L
D
-
E
L
R
-
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
-----
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
D
T----
K
-
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
-
R
L
Q
A
H
-------------------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
95
PsiBlast_CBE
74.03
43%
-86
- C4 -
4N5S
12
DPO1_THEAQ
A:
[93-552]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
--
G
V
A
R
R
Y
G
G
E
W
T
E
E
-------
A
G
E
R
-------------
A
A
L
S
E
R
L
F
-
A
----
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
-
R
-----
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
---
P
V
R
T
P
L
G
Q
------
R
I
R
R
----
A
F
I
-
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
L
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
-
G
--
A
R
-------------------
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
-------
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
----
100
PsiBlast_CBE
73.91
43%
-87
- C4 -
1QSY
5
DPO1_THEAQ
A:
[80-539]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
--
G
V
A
R
R
Y
G
G
E
W
T
E
E
-------
A
G
E
R
-------------
A
A
L
S
E
R
L
F
-
A
----
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
-
R
-----
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
---
P
V
R
T
P
L
G
Q
------
R
I
R
R
----
A
F
I
-
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
-
G
--
A
R
-------------------
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
-------
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
----
94
PsiBlast_CBE
73.43
43%
-86
- C4 -
4XIU
3
DPO1_THEAQ
A:
[79-538]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
--
G
V
A
R
R
Y
G
G
E
W
T
E
E
-------
A
G
E
R
-------------
A
A
L
S
E
R
L
F
-
A
----
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
-
R
-----
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
---
P
V
R
T
P
L
G
Q
------
R
I
R
R
----
A
F
I
-
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
L
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
-
G
--
A
R
-------------------
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
-------
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
----
104
Fugue
73.05
31%
-64
- C4 -
4XVK
4
DPOLN_HUMAN
A:
[1-666]
-----------------------------------------------------------------------------------
K
K
H
F
C
D
I
R
H
L
-----------
D
D
W
A
K
S
Q
L
I
E
M
L
K
Q
----
A
A
A
L
V
I
T
V
M
Y
T
D
G
S
T
Q
L
G
A
D
Q
-----------------------------------------
T
P
V
S
S
V
R
G
I
V
V
L
V
K
R
Q
A
C
--------------------
G
P
V
L
E
G
F
V
S
D
----------------
D
P
C
I
Y
I
Q
I
E
H
S
--
A
I
W
D
Q
E
Q
E
A
H
Q
Q
F
A
R
N
V
L
F
Q
T
M
K
-----------------------------
C
K
C
P
V
I
C
F
--
N
A
K
D
F
V
R
I
V
L
Q
F
F
G
N
D
G
S
W
K
H
V
A
------------------------------------------
D
F
I
G
L
D
P
R
I
A
A
W
L
I
D
P
S
D
A
T
P
S
F
E
D
L
V
E
K
Y
C
E
K
S
I
T
V
K
V
N
S
T
Y
G
N
------
S
S
R
N
I
V
N
Q
N
V
R
E
N
L
K
T
L
Y
-
R
L
T
-
M
D
L
C
S
K
L
K
-
D
Y
G
L
W
Q
L
F
R
T
L
E
L
P
L
I
P
I
L
A
V
M
E
S
H
A
I
Q
V
N
K
E
E
M
E
K
T
S
A
L
L
G
A
R
L
K
E
L
E
Q
E
A
H
F
V
A
G
E
R
F
L
I
T
S
N
N
Q
L
R
E
I
L
F
G
K
L
K
L
H
L
L
S
Y
P
------
S
T
S
E
A
V
L
N
A
L
R
D
L
H
P
L
P
K
I
I
L
E
Y
R
Q
V
H
K
I
K
S
T
F
V
D
G
L
L
A
C
M
K
K
-
G
-------
S
I
S
S
T
W
N
Q
T
G
T
V
T
G
R
L
S
A
K
H
P
N
I
Q
G
I
SK
H
P
I
Q
I
T
T
P
K
------
K
I
L
T
I
S
PR
A
M
F
V
S
S
K
G
H
T
F
L
A
A
D
F
S
Q
I
E
L
R
I
L
T
H
L
S
G
D
P
E
L
L
K
L
----
D
D
V
F
S
T
L
T
S
Q
W
K
D
V
P
V
E
Q
V
T
H
A
D
R
E
Q
T
K
K
V
V
Y
A
V
V
Y
G
A
G
K
E
R
L
A
A
C
L
G
V
P
I
Q
E
A
A
Q
F
L
E
S
F
L
Q
K
Y
K
K
I
K
D
F
A
R
A
A
I
A
Q
C
H
Q
T
G
C
V
V
S
I
M
G
R
R
R
P
L
P
R
I
H
A
H
D
Q
Q
L
R
A
Q
A
E
R
Q
A
V
N
F
V
V
Q
G
S
A
A
D
L
C
K
L
A
M
I
H
V
F
T
A
V
A
A
S
H
T
L
T
A
R
-------------------
L
V
A
Q
I
H
D
E
L
L
F
E
V
E
D
P
Q
I
P
E
C
A
A
L
V
R
R
T
M
E
S
L
EQVQALE
L
Q
L
Q
V
P
L
K
V
S
L
S
A
G
R
S
W
G
H
L
V
PLQ-
99
PsiBlast_CBE
71.83
43%
-83
- C4 -
4KTQ
2
DPO1_THEAQ
A:
[79-538]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
--
G
V
A
R
R
Y
G
G
E
W
T
E
E
-------
A
G
E
R
-------------
A
A
L
S
E
R
L
F
-
A
----
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
-
R
-----
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
---
P
V
R
T
P
L
G
Q
------
R
I
R
R
----
A
F
I
-
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
-
G
--
A
R
-------------------
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
-------
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
----
98
PsiBlast_CBE
71.65
43%
-87
- C4 -
5KTQ
1
DPO1_THEAQ
A:
[83-542]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
--
G
V
A
R
R
Y
G
G
E
W
T
E
E
-------
A
G
E
R
-------------
A
A
L
S
E
R
L
F
-
A
----
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
---------
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
-
R
-----
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
---
P
V
R
T
P
L
G
Q
------
R
I
R
R
----
A
F
I
-
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
-
G
--
A
R
-------------------
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
-------
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
----
97
PsiBlast_CBE
71.42
43%
-86
- C4 -
2KTQ
4
DPO1_THEAQ
A:
[78-537]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
--
G
V
A
R
R
Y
G
G
E
W
T
E
E
-------
A
G
E
R
-------------
A
A
L
S
E
R
L
F
-
A
----
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
-
R
-----
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
---
P
V
R
T
P
L
G
Q
------
R
I
R
R
----
A
F
I
-
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
----------
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
-
G
--
A
R
-------------------
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
-------
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
----
96
PsiBlast_CBE
68.83
43%
-92
- C4 -
4N56
4
DPO1_THEAQ
A:
[93-552]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
--
G
V
A
R
R
Y
G
G
E
W
T
E
E
-------
A
G
E
R
-------------
A
A
L
S
E
R
L
F
-
A
----
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
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105
Fugue
68.82
30%
-69
- C4 -
4X0Q
7
DPOLQ_HUMAN
A:
[6-772]
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