@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1545: (2016-03-26 )
MKQFNVLVADPISKDGIKALLDHEQFNVDIQTGLSEEALIKIIPSYHALIVRSQTTVTENIINAADSLKVIARAGVGVDNININAATLKGILVINAPDGNTISATEHSLAMLLSMARNIPQAHQSLTNKEWNRNAFKGTELYHKTLGVIGAGRIGLGVAKRAQSFGMKILAFDPYLTDEKAKSLSITKATVDEIAQHSDFVTLHTPLTPKTKGLINADFFAKAKPSLQIINVARGGIIDEKALIKALDEGQISRAAIDVFEHEPATDSPLVAHDKIIVTPHLGASTVEAQEKVAISVSNEIIEILIDGTVTHAVNAPKMDLSNIDDTVKSFINLSQTVGELAIQLMYNAPSSIKITYGGDLASIDSSLLTRTIITHILKDDLGPEVNIINALMLLNQQQVTLNIENNKAETGFSNYLEVELSNDSDSVKVGASVFTGFGPRIVRINNFSVDLKPNQYQIVSYHNDTPGMVGKTGALLGKYNINIASMTLGRTEAGGDALMILSVDQPVSNNIIDELKQVGEYNQIFTTELTVQS
Atome Classification :
(30 SA)
.........10........20-.........30--..---.-.--.....40........50........60....-....70........80........90......----..100.......110.......120......-------.------130...-------....-140.......150.......160.......170.......180......-.-.190--.........200.......210.......220.-......230.......240.......250.......260..-..---.-----.--.270.-......280.----......290..-.....300.......310.......320.......330.......340.......350.......360.-......370.......380.......390.......400.....-..410.......420.....-...430......-.--440--.........450.......460.......470.......480.......490.......500.....--..510.......520.......530..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
Q
F
N
V
L
V
ADPIS
K
D
G
I
K
A
L
--LDHE
Q
F
N
V
D
I---QT---G-L--
S
E
E
A
L
I
K
I
IPS
Y
H
A
L
I
V
RSQT
T
V
T
E
N
I
I
N
A
A
-
D
S
L
K
V
I
A
RAGVGVD
N
I
N
I
N
A
A
T
L
K
G
I
L
V
I
NAP----DG
N
T
I
S
A
T
E
H
S
L
A
M
L
L
S
M
A
RNI
P
Q
A
H
Q
S
L
T
N
-------
K
------EWNRNA-------FK
G
T
-
E
L
Y
H
K
T
L
G
VIGAGRI
G
L
G
V
A
K
R
A
Q
SFG
M
K
I
L
A
FDPYLTDEK-AKSLS
I
T
-
K
-
A
T
----
V
D
E
I
AQHS
D
F
V
T
L
HTPLTPKTKGLIN
A
D
F
FAKA-KP
S
L
Q
I
I
N
VARGGII
D
E
K
A
L
I
K
A
L
DEGQ
I
S
R
A
A
I
D
VFEHEP-AT---D-----S--PLVAH-
D
K
I
I
V
TPHLG----AS
T
V
EAQ
E
K
V
A
-
I
SVS
N
E
I
I
E
I
LIDGT
V
T
HAVNAPKMDL
S
N
I
D
D
T
V
K
S
F
I
N
L
S
Q
T
V
G
E
L
A
I
Q
L
MYNAP
S
S
I
K
I
T
YGG
D
L
A
S
-
I
D
S
S
L
L
T
R
T
I
I
T
H
I
L
K
D
DLGP
E
V
N
I
I
N
A
L
M
LLNQ
Q
Q
V
T
L
N
IENN-KAETGFS
N
Y
L
E
V
E
-LSNDSD-
S
V
K
V
G
A
S
V
FTGF-G--
P
----
R
I
V
R
I
N
N
F
S
V
DLKPN
Q
Y
Q
I
V
S
YHNDTPGMVGKT
G
A
L
L
G
K
Y
N
I
N
I
A
S
M
TLGRTEAGG
D
A
L
M
I
L
SVDQP--VS
N
N
I
I
D
E
L
K
QVGEYN
Q
I
F
T
T
E
L
T
VQS
81
Fugue
96.88
35%
-103
- C2 -
1YGY
1
SERA_MYCTU
A:
[3-529]
-
S
L
P
V
V
L
I
A
D
K
L
A
P
S
T
V
A
A
L
----
G
D
Q
V
E
V
R
W
---
V
D
---
G
-
P
--
D
R
D
K
L
L
A
A
V
P
E
A
D
A
L
L
V
R
S
A
T
T
V
D
A
E
V
L
A
A
A
-
P
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
----
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
-------
H
------
T
W
K
R
S
S
-------
F
S
G
T
-
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
Y
V
S
P
A
R
-
A
A
Q
L
G
I
E
-
L
-
L
S
----
L
D
D
L
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
-
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
T
---
D
-----
S
--
P
L
F
E
L
-
A
Q
V
V
V
T
P
H
L
G
----
A
S
T
A
E
A
Q
D
R
A
G
-
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
V
G
G
G
V
V
---
N
E
E
V
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
S
D
E
L
P
V
S
L
S
V
Q
V
R
G
E
L
A
A
-
E
E
V
E
V
L
R
L
S
A
L
R
G
L
F
S
A
V
I
E
D
A
V
T
F
V
N
A
P
A
L
A
A
E
R
G
V
T
A
E
I
C
K
A
-
S
E
S
P
N
H
R
S
V
V
D
V
R
-
A
V
G
A
D
G
-
S
V
V
T
V
S
G
T
L
Y
G
P
-
Q
LS
Q
----
K
I
V
Q
I
N
G
R
H
F
D
L
R
A
Q
G
I
N
L
I
I
H
Y
V
D
R
P
G
A
L
G
K
I
G
T
L
L
G
T
A
G
V
N
I
Q
A
A
Q
L
S
E
D
A
E
G
P
G
A
T
I
L
L
R
L
D
Q
D
--
V
P
D
D
V
R
T
A
I
A
A
A
V
D
A
Y
K
L
E
V
V
D
L
S
---
91
HHSearch
96.23
35%
-107
- C2 -
1YGY
1
SERA_MYCTU
A:
[3-529]
-
S
L
P
V
V
L
I
A
D
K
L
A
P
S
T
V
A
A
L
--
G
D
Q
--
V
E
V
R
W
---
V
D
---
G
-
P
--
D
R
D
K
L
L
A
A
V
P
E
A
D
A
L
L
V
R
S
A
T
T
V
D
A
E
V
L
A
A
A
-
P
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
----
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
-------
H
------
T
W
K
R
S
S
-------
F
S
G
T
-
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
Y
V
S
P
A
R
-
A
A
Q
L
G
I
E
-
L
-
L
S
----
L
D
D
L
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
-
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
T
---
D
-----
S
--
P
L
F
-
E
L
A
Q
V
V
V
T
P
H
L
G
----
A
S
T
A
E
A
Q
D
R
A
G
-
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
V
G
G
--
G
V
V
N
-
E
E
V
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
S
D
E
L
P
V
S
L
S
V
Q
V
R
G
E
L
A
A
E
E
V
E
V
L
R
L
S
A
L
R
G
L
F
S
A
V
-
I
E
D
A
V
T
F
V
N
A
P
A
L
A
A
E
R
G
V
T
A
E
I
C
K
A
S
E
S
-
P
N
H
R
S
V
V
D
V
R
-
A
V
G
A
D
G
S
V
V
T
V
S
G
T
L
Y
G
P
Q
L
S
--
Q
----
K
I
V
Q
I
N
G
R
H
F
D
L
R
A
Q
G
I
N
L
I
I
H
Y
V
D
R
P
G
A
L
G
K
I
G
T
L
L
G
T
A
G
V
N
I
Q
A
A
Q
L
S
E
D
A
E
G
P
G
A
T
I
L
L
R
L
D
Q
D
--
V
P
D
D
V
R
T
A
I
A
A
A
V
D
A
Y
K
L
E
V
V
D
L
S
---
3
PsiBlast_PDB
95.67
36%
-112
- C2 -
3DDN
2
SERA_MYCTU
A:
[6-509]
-----
V
L
I
A
D
K
L
A
P
S
T
V
A
A
L
--
G
D
--
Q
V
E
V
R
W
---
V
D
---
G
-
P
--
D
R
D
K
L
L
A
A
V
P
E
A
D
A
L
L
V
R
S
A
T
T
V
D
A
E
V
L
A
A
A
-
P
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
----
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
-------
H
------
T
W
K
R
S
S
-------
F
S
G
T
-
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
Y
V
S
P
A
R
-
A
A
Q
L
G
I
E
-
L
-
L
S
----
L
D
D
L
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
-
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
T
---
D
-----
S
--
P
L
F
E
L
-
A
Q
V
V
V
T
P
H
L
G
----
A
S
T
A
E
A
Q
D
R
A
G
-
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
---
V
G
G
G
V
V
N
E
E
V
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
S
D
E
L
P
V
S
L
S
V
Q
V
R
G
E
L
A
A
-
E
E
V
E
V
L
R
L
S
A
L
R
G
L
F
S
A
V
I
E
D
A
V
T
F
V
N
A
P
A
L
A
A
E
R
G
V
T
A
E
I
C
K
A
-
S
E
S
P
N
H
R
S
V
V
D
V
R
A
V
G
A
D
G
S
-
V
V
T
V
S
G
T
L
---
Y
-
G
--
P
QLSQ
K
I
V
Q
I
N
G
R
H
F
D
L
R
A
Q
G
I
N
L
I
I
H
Y
V
D
R
P
G
A
L
G
K
I
G
T
L
L
G
T
A
G
V
N
I
Q
A
A
Q
L
S
E
D
A
E
G
P
G
A
T
I
L
L
R
L
D
Q
D
--
V
P
D
D
V
----------------------
2
PsiBlast_PDB
95.64
36%
-113
- C2 -
3DC2
2
SERA_MYCTU
A:
[7-510]
-----
V
L
I
A
D
K
L
A
P
S
T
V
A
A
L
--
G
D
--
Q
V
E
V
R
W
---
V
D
---
G
-
P
--
D
R
D
K
L
L
A
A
V
P
E
A
D
A
L
L
V
R
S
A
T
T
V
D
A
E
V
L
A
A
A
-
P
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
----
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
-------
H
------
T
W
K
R
S
S
-------
F
S
G
T
-
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
Y
V
S
P
A
R
-
A
A
Q
L
G
I
E
-
L
-
L
S
----
L
D
D
L
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
-
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
T
---
D
-----
S
--
P
L
F
E
L
-
A
Q
V
V
V
T
P
H
L
G
----
A
S
T
A
E
A
Q
D
R
A
G
-
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
---
V
G
G
G
V
V
N
E
E
V
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
S
D
E
L
P
V
S
L
S
V
Q
V
R
G
E
L
A
A
-
E
E
V
E
V
L
R
L
S
A
L
R
G
L
F
S
A
V
I
E
D
A
V
T
F
V
N
A
P
A
L
A
A
E
R
G
V
T
A
E
I
C
K
A
-
S
E
S
P
N
H
R
S
V
V
D
V
R
A
V
G
A
D
G
S
-
V
V
T
V
S
G
T
L
---
Y
-
G
--
P
QLSQ
K
I
V
Q
I
N
G
R
H
F
D
L
R
A
Q
G
I
N
L
I
I
H
Y
V
D
R
P
G
A
L
G
K
I
G
T
L
L
G
T
A
G
V
N
I
Q
A
A
Q
L
S
E
D
A
E
G
P
G
A
T
I
L
L
R
L
D
Q
D
--
V
P
D
D
V
----------------------
1
PsiBlast_PDB
95.49
36%
-113
- C2 -
1YGY
1
SERA_MYCTU
A:
[7-510]
-----
V
L
I
A
D
K
L
A
P
S
T
V
A
A
L
--
G
D
--
Q
V
E
V
R
W
---
V
D
---
G
-
P
--
D
R
D
K
L
L
A
A
V
P
E
A
D
A
L
L
V
R
S
A
T
T
V
D
A
E
V
L
A
A
A
-
P
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
----
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
-------
H
------
T
W
K
R
S
S
-------
F
S
G
T
-
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
Y
V
S
P
A
R
-
A
A
Q
L
G
I
E
-
L
-
L
S
----
L
D
D
L
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
-
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
T
---
D
-----
S
--
P
L
F
E
L
-
A
Q
V
V
V
T
P
H
L
G
----
A
S
T
A
E
A
Q
D
R
A
G
-
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
---
V
G
G
G
V
V
N
E
E
V
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
S
D
E
L
P
V
S
L
S
V
Q
V
R
G
E
L
A
A
-
E
E
V
E
V
L
R
L
S
A
L
R
G
L
F
S
A
V
I
E
D
A
V
T
F
V
N
A
P
A
L
A
A
E
R
G
V
T
A
E
I
C
K
A
-
S
E
S
P
N
H
R
S
V
V
D
V
R
A
V
G
A
D
G
S
-
V
V
T
V
S
G
T
L
---
Y
-
G
--
P
QLSQ
K
I
V
Q
I
N
G
R
H
F
D
L
R
A
Q
G
I
N
L
I
I
H
Y
V
D
R
P
G
A
L
G
K
I
G
T
L
L
G
T
A
G
V
N
I
Q
A
A
Q
L
S
E
D
A
E
G
P
G
A
T
I
L
L
R
L
D
Q
D
--
V
P
D
D
V
----------------------
22
PsiBlast_CBE
94.05
36%
-106
- C2 -
1YGY
2
SERA_MYCTU
B:
[7-510]
-----
V
L
I
A
D
K
L
A
P
S
T
V
A
A
L
--
G
D
--
Q
V
E
V
R
W
---
V
D
---
G
-
P
--
D
R
D
K
L
L
A
A
V
P
E
A
D
A
L
L
V
R
S
A
T
T
V
D
A
E
V
L
A
A
A
-
P
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
----
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
-------
H
------
T
W
K
R
S
S
-------
F
S
G
T
-
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
Y
V
S
P
A
R
-
A
A
Q
L
G
I
E
-
L
-
L
S
----
L
D
D
L
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
-
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
T
---
D
-----
S
--
P
L
F
E
L
-
A
Q
V
V
V
T
P
H
L
G
----
A
S
T
A
E
A
Q
D
R
A
G
-
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
---
V
G
G
G
V
V
N
E
E
V
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
S
D
E
L
P
V
S
L
S
V
Q
V
R
G
E
L
A
A
-
E
E
V
E
V
L
R
L
S
A
L
R
G
L
F
S
A
V
I
E
D
A
V
T
F
V
N
A
P
A
L
A
A
E
R
G
V
T
A
E
I
C
K
A
-
S
E
S
P
N
H
R
S
V
V
D
V
R
A
V
G
A
D
G
S
-
V
V
T
V
S
G
T
L
---
Y
-
G
--
P
QLSQ
K
I
V
Q
I
N
G
R
H
F
D
L
R
A
Q
G
I
N
L
I
I
H
Y
V
D
R
P
G
A
L
G
K
I
G
T
L
L
G
T
A
G
V
N
I
Q
A
A
Q
L
S
E
D
A
E
G
P
G
A
T
I
L
L
R
L
D
Q
D
--
V
P
D
D
V
----------------------
21
PsiBlast_CBE
92.70
36%
-107
- C2 -
3DC2
3
SERA_MYCTU
B:
[7-510]
-----
V
L
I
A
D
K
L
A
P
S
T
V
A
A
L
--
G
D
--
Q
V
E
V
R
W
---
V
D
---
G
-
P
--
D
R
D
K
L
L
A
A
V
P
E
A
D
A
L
L
V
R
S
A
T
T
V
D
A
E
V
L
A
A
A
-
P
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
----
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
-------
H
------
T
W
K
R
S
S
-------
F
S
G
T
-
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
Y
V
S
P
A
R
-
A
A
Q
L
G
I
E
-
L
-
L
S
----
L
D
D
L
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
-
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
T
---
D
-----
S
--
P
L
F
E
L
-
A
Q
V
V
V
T
P
H
L
G
----
A
S
T
A
E
A
Q
D
R
A
G
-
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
---
V
G
G
G
V
V
N
E
E
V
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
S
D
E
L
P
V
S
L
S
V
Q
V
R
G
E
L
A
A
-
E
E
V
E
V
L
R
L
S
A
L
R
G
L
F
S
A
V
I
E
---
T
F
V
N
A
P
A
L
A
A
E
R
G
V
T
A
E
I
C
K
A
-
S
E
S
P
N
H
R
S
V
V
D
V
R
A
V
G
A
D
G
S
-
V
V
T
V
S
G
T
L
---
Y
-
G
--
P
QL
S
Q
K
I
V
Q
I
N
G
R
H
F
D
L
R
A
Q
G
I
N
L
I
I
H
Y
V
D
R
P
G
A
L
G
K
I
G
T
L
L
G
T
A
G
V
N
I
Q
A
A
Q
L
S
E
D
A
E
G
P
G
A
T
I
L
L
R
L
D
Q
D
--
V
P
D
D
V
----------------------
23
PsiBlast_CBE
92.53
36%
-105
- C2 -
3DDN
3
SERA_MYCTU
B:
[6-509]
-----
V
L
I
A
D
K
L
A
P
S
T
V
A
A
L
--
G
D
--
Q
V
E
V
R
W
---
V
D
---
G
-
P
--
D
R
D
K
L
L
A
A
V
P
E
A
D
A
L
L
V
R
S
A
T
T
V
D
A
E
V
L
A
A
A
-
P
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
----
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
-------
H
------
T
W
K
R
S
S
-------
F
S
G
T
-
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
Y
V
S
P
A
R
-
A
A
Q
L
G
I
E
-
L
-
L
S
----
L
D
D
L
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
-
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
T
---
D
-----
S
--
P
L
F
E
L
-
A
Q
V
V
V
T
P
H
L
G
----
A
S
T
A
E
A
Q
D
R
A
G
-
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
---
V
G
G
G
V
V
N
E
E
V
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
S
D
E
L
P
V
S
L
S
V
Q
V
R
G
E
L
A
A
-
E
E
V
E
V
L
R
L
S
A
L
R
G
L
F
S
A
V
I
E
--
V
T
F
V
N
A
P
A
L
A
A
E
R
G
V
T
A
E
I
C
K
A
-
S
E
S
P
N
H
R
S
V
V
D
V
R
A
V
G
A
D
G
S
-
V
V
T
V
S
G
T
L
---
Y
-
G
--
P
QLSQ
K
I
V
Q
I
N
G
R
H
F
D
L
R
A
Q
G
I
N
L
I
I
H
Y
V
D
R
P
G
A
L
G
K
I
G
T
L
L
G
T
A
G
V
N
I
Q
A
A
Q
L
S
E
D
A
E
G
P
G
A
T
I
L
L
R
L
D
Q
D
--
V
P
D
D
V
----------------------
95
HHSearch
79.95
45%
-112
* C2 *
2G76
3
SERA_HUMAN
A:
[26-327]
--
L
R
K
V
L
I
S
D
S
L
D
P
C
C
R
K
I
L
--
Q
D
G
-
G
L
Q
V
V
E
---
K
Q
---
N
-
L
--
S
K
E
E
L
I
A
E
L
Q
D
C
E
G
L
I
V
R
S
A
T
K
V
T
A
D
V
I
N
A
A
-
E
K
L
Q
V
V
G
R
A
G
T
G
V
D
N
V
D
L
E
A
A
T
R
K
G
I
L
V
M
N
T
P
----
N
G
N
S
L
S
A
A
E
L
T
C
G
M
I
M
C
L
A
R
Q
I
P
Q
A
T
A
S
M
K
D
-------
G
------
K
W
E
R
K
K
-------
F
M
G
T
-
E
L
N
G
K
T
L
G
I
L
G
L
G
R
I
G
R
E
V
A
T
R
M
Q
S
F
G
M
K
T
I
G
Y
D
P
I
I
S
P
E
V
-
S
A
S
F
G
V
Q
-
Q
-
L
P
----
L
E
E
I
W
P
L
C
D
F
I
T
V
H
T
P
L
L
P
S
T
T
G
L
L
N
D
N
T
F
A
Q
C
-
K
K
G
V
R
V
V
N
C
A
R
G
G
I
V
D
E
G
A
L
L
R
A
L
Q
S
G
Q
C
A
G
A
A
L
D
V
F
T
E
E
P
-
P
R
---
D
-----
R
--
A
L
V
-
D
H
E
N
V
I
S
C
P
H
L
G
----
A
S
T
K
E
A
Q
S
R
C
G
-
E
E
I
A
V
Q
F
V
D
M
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
78.21
45%
-110
- C2 -
2G76
3
SERA_HUMAN
A:
[29-327]
-----
V
L
I
S
D
S
L
D
P
C
C
R
K
I
L
--
Q
D
G
G
L
Q
V
V
E
K
---
Q
N
-----
L
--
S
K
E
E
L
I
A
E
L
Q
D
C
E
G
L
I
V
R
S
A
T
K
V
T
A
D
V
I
N
A
A
-
E
K
L
Q
V
V
G
R
A
G
T
G
V
D
N
V
D
L
E
A
A
T
R
K
G
I
L
V
M
N
T
P
----
N
G
N
S
L
S
A
A
E
L
T
C
G
M
I
M
C
L
A
R
Q
I
P
Q
A
T
A
S
M
K
D
-------
G
------
K
W
E
R
K
K
-------
F
M
G
T
-
E
L
N
G
K
T
L
G
I
L
G
L
G
R
I
G
R
E
V
A
T
R
M
Q
S
F
G
M
K
T
I
G
Y
D
P
I
I
S
P
E
V
-
S
A
S
F
G
V
Q
-
Q
-
L
P
----
L
E
E
I
W
P
L
C
D
F
I
T
V
H
T
P
L
L
P
S
T
T
G
L
L
N
D
N
T
F
A
Q
C
-
K
K
G
V
R
V
V
N
C
A
R
G
G
I
V
D
E
G
A
L
L
R
A
L
Q
S
G
Q
C
A
G
A
A
L
D
V
F
T
E
E
P
-
P
R
---
D
-----
R
--
A
L
V
D
H
-
E
N
V
I
S
C
P
H
L
G
----
A
S
T
K
E
A
Q
S
R
C
G
-
E
E
I
A
V
Q
F
V
D
M
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
78.12
45%
-109
- C2 -
2G76
3
SERA_HUMAN
B:
[29-327]
-----
V
L
I
S
D
S
L
D
P
C
C
R
K
I
L
--
Q
D
G
G
L
Q
V
V
E
K
---
Q
N
-----
L
--
S
K
E
E
L
I
A
E
L
Q
D
C
E
G
L
I
V
R
S
A
T
K
V
T
A
D
V
I
N
A
A
-
E
K
L
Q
V
V
G
R
A
G
T
G
V
D
N
V
D
L
E
A
A
T
R
K
G
I
L
V
M
N
T
P
----
N
G
N
S
L
S
A
A
E
L
T
C
G
M
I
M
C
L
A
R
Q
I
P
Q
A
T
A
S
M
K
D
-------
G
------
K
W
E
R
K
K
-------
F
M
G
T
-
E
L
N
G
K
T
L
G
I
L
G
L
G
R
I
G
R
E
V
A
T
R
M
Q
S
F
G
M
K
T
I
G
Y
D
P
I
I
S
P
E
V
-
S
A
S
F
G
V
Q
-
Q
-
L
P
----
L
E
E
I
W
P
L
C
D
F
I
T
V
H
T
P
L
L
P
S
T
T
G
L
L
N
D
N
T
F
A
Q
C
-
K
K
G
V
R
V
V
N
C
A
R
G
G
I
V
D
E
G
A
L
L
R
A
L
Q
S
G
Q
C
A
G
A
A
L
D
V
F
T
E
E
P
-
P
R
---
D
-----
R
--
A
L
V
D
H
-
E
N
V
I
S
C
P
H
L
G
----
A
S
T
K
E
A
Q
S
R
C
G
-
E
E
I
A
V
Q
F
V
D
M
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
HHSearch
77.55
42%
-114
- C2 -
1WWK
1
?
A:
[4-307]
---
M
K
V
L
V
A
A
P
L
H
E
K
A
I
Q
V
L
--
K
D
A
G
-
L
E
V
I
Y
---
E
E
---
Y
-
P
--
D
E
D
R
L
V
E
L
V
K
D
V
E
A
I
I
V
R
S
K
P
K
V
T
R
R
V
I
E
S
A
-
P
K
L
K
V
I
A
R
A
G
V
G
L
D
N
I
D
V
E
A
A
K
E
K
G
I
E
V
V
N
A
P
----
A
A
S
S
R
S
V
A
E
L
A
V
G
L
M
F
S
V
A
R
K
I
A
F
A
D
R
K
M
R
E
-------
G
------
V
W
A
K
K
E
-------
A
M
G
I
-
E
L
E
G
K
T
I
G
I
I
G
F
G
R
I
G
Y
Q
V
A
K
I
A
N
A
L
G
M
N
I
L
L
Y
D
P
Y
P
N
E
E
R
-
A
K
E
V
N
G
K
-
F
-
V
D
----
L
E
T
L
L
K
E
S
D
V
V
T
I
H
V
P
L
V
E
S
T
Y
H
L
I
N
E
E
R
L
K
L
M
-
K
K
T
A
I
L
I
N
T
S
R
G
P
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
L
P
K--
D
-----
H
--
P
L
T
-
K
F
D
N
V
V
L
T
P
H
I
G
----
A
S
T
V
E
A
Q
E
R
A
G
-
V
E
V
A
E
K
V
V
K
I
L
K
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
77.40
42%
-113
- C2 -
1WWK
1
?
A:
[4-305]
---
M
K
V
L
V
A
A
P
L
H
E
K
A
I
Q
V
L
--
K
D
A
-
G
L
E
V
I
Y
---
E
E
---
Y
-
P
--
D
E
D
R
L
V
E
L
V
K
D
V
E
A
I
I
V
R
S
K
P
K
V
T
R
R
V
I
E
S
A
-
P
K
L
K
V
I
A
R
A
G
V
G
L
D
N
I
D
V
E
A
A
K
E
K
G
I
E
V
V
N
A
P
----
A
A
S
S
R
S
V
A
E
L
A
V
G
L
M
F
S
V
A
R
K
I
A
F
A
D
R
K
M
R
E
-------
G
------
V
W
A
K
K
E
-------
A
M
G
I
-
E
L
E
G
K
T
I
G
I
I
G
F
G
R
I
G
Y
Q
V
A
K
I
A
N
A
L
G
M
N
I
L
L
Y
D
P
Y
P
N
E
E
R
-
A
K
E
V
N
G
K
-
F
-
V
D
----
L
E
T
L
L
K
E
S
D
V
V
T
I
H
V
P
L
V
E
S
T
Y
H
L
I
N
E
E
R
L
K
L
M
-
K
K
T
A
I
L
I
N
T
S
R
G
P
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
L
P
K
---
D
-----
H
--
P
L
T
K
F
-
D
N
V
V
L
T
P
H
I
G
----
A
S
T
V
E
A
Q
E
R
A
G
-
V
E
V
A
E
K
V
V
K
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
75.92
42%
-113
- C2 -
1WWK
1
?
B:
[4-305]
---
M
K
V
L
V
A
A
P
L
H
E
K
A
I
Q
V
L
--
K
D
A
-
G
L
E
V
I
Y
---
E
E
---
Y
-
P
--
D
E
D
R
L
V
E
L
V
K
D
V
E
A
I
I
V
R
S
K
P
K
V
T
R
R
V
I
E
S
A
-
P
K
L
K
V
I
A
R
A
G
V
G
L
D
N
I
D
V
E
A
A
K
E
K
G
I
E
V
V
N
A
P
----
A
A
S
S
R
S
V
A
E
L
A
V
G
L
M
F
S
V
A
R
K
I
A
F
A
D
R
K
M
R
E
-------
G
------
V
W
A
K
K
E
-------
A
M
G
I
-
E
L
E
G
K
T
I
G
I
I
G
F
G
R
I
G
Y
Q
V
A
K
I
A
N
A
L
G
M
N
I
L
L
Y
D
P
Y
P
N
E
E
R
-
A
K
E
V
N
G
K
-
F
-
V
D
----
L
E
T
L
L
K
E
S
D
V
V
T
I
H
V
P
L
V
E
S
T
Y
H
L
I
N
E
E
R
L
K
L
M
-
K
K
T
A
I
L
I
N
T
S
R
G
P
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
L
P
K
---
D
-----
H
--
P
L
T
K
F
-
D
N
V
V
L
T
P
H
I
G
----
A
S
T
V
E
A
Q
E
R
A
G
-
V
E
V
A
E
K
V
V
K
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
HHSearch
74.94
31%
-97
- C2 -
3K5P
4
?
A:
[13-415]
R
D
R
I
N
V
L
L
L
E
G
I
S
Q
T
A
V
E
Y
F
--
K
S
S
G
-
Y
T
N
V
T
H
--
L
P
K
--
A
-
L
--
D
K
A
D
L
I
K
A
I
S
S
A
H
I
I
G
I
R
S
R
T
Q
L
T
E
E
I
F
A
A
A
-
N
R
L
I
A
V
G
C
F
S
V
G
T
N
Q
V
E
L
K
A
A
R
K
R
G
I
P
V
F
N
A
P
----
F
S
N
T
R
S
V
A
E
L
V
I
G
E
I
I
M
L
M
R
R
I
F
P
R
S
V
S
A
H
A
-------
G
------
G
W
E
K
T
A
-------
I
G
S
R
-
E
V
R
G
K
T
L
G
I
V
G
Y
G
N
I
G
S
Q
V
G
N
L
A
E
S
L
G
M
T
V
R
Y
Y
D
T
S
D
K
L
Q
Y
----
G
N
V
K
P
A
-
A
S
----
L
D
E
L
L
K
T
S
D
V
V
S
L
H
V
P
-----
S
K
L
I
T
E
A
K
L
R
K
M
-
K
K
G
A
F
L
I
N
N
A
R
G
S
D
V
D
L
E
A
L
A
K
V
L
Q
E
G
H
L
A
G
A
A
I
D
V
F
P
V
E
P
-
A
S
N--
G
E
R
F
S
-
T
--
P
L
Q
-
G
L
E
N
V
I
L
T
P
H
I
G
----
G
S
T
E
E
A
Q
E
R
I
G
-
T
E
V
T
R
K
L
V
E
Y
S
D
V
G
S
T
V
G
A
V
N
F
P
Q
V
--
Q
L
P
-------------------
P
R
-
P
T
----------------------------------------------------------------------------------------------------------------------
G
T
R
F
M
H
V
H
E
N
R
P
G
I
L
N
S
L
M
N
V
F
S
H
H
H
I
N
I
A
S
Q
F
L
--
Q
T
D
G
E
V
G
Y
L
V
M
E
A
D
G
V
G
E
A
S
D
A
V
L
Q
E
I
R
E
I
P
G
T
I
R
A
R
L
L
------
92
HHSearch
72.48
29%
-100
- C2 -
1SC6
1
SERA_ECOLI
A:
[3-403]
-
D
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
--
R
A
A
G
-
Y
T
N
I
E
F
--
H
K
G
--
A
-
L
--
D
D
E
Q
L
K
E
S
I
R
D
A
H
F
I
G
L
R
S
R
T
H
L
T
E
D
V
I
N
A
A
-
E
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
----
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
-------
G
------
V
G
N
------------
S
F
-
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
I
E
N
K
L
P
L
----
G
N
A
T
Q
V
-
Q
H
----
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
-
K
P
G
S
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
--------DPF
T
-----
S
--
P
L
A
-
E
F
D
N
V
L
L
T
P
H
I
G
----
G
S
T
Q
E
A
Q
E
N
I
G
-
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
E
V
S
------------------------------------------------------------------------------------------
L
P
L
---------------------------------------------------
H
G
G
R
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
T
S
A
Q
M
G
Y
V
V
I
D
I
E
A
D
E
D
V
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
------
97
HHSearch
72.38
34%
-105
- C2 -
2DBQ
8
GYAR_PYRHO
A:
[1-327]
-
M
K
P
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
--
E
D
E
--
F
E
V
E
V
---
W
G
D
EK
E
-
I
--
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
----
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
-------
G
------
E
W
K
K
R
G
VAWHPKW
F
L
G
Y
-
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
I
L
Y
Y
S
R
T
R
K
E
E
V
-
E
R
E
L
N
A
E
-
F
-
K
P
----
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
-
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
---
N
-----
E
--
E
L
F
-
K
L
D
N
V
V
L
T
P
H
I
G
----
S
A
S
F
G
A
R
E
G
M
A
-
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
R
E
V
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
HHSearch
72.11
28%
-108
- C2 -
2GCG
3
GRHPR_HUMAN
A:
[7-329]
-
R
L
M
K
V
F
V
T
R
R
I
P
A
E
G
R
V
A
L
--
A
R
A
A
D
C
E
V
E
Q
---
W
D
SDE
P
-
I
--
P
A
K
E
L
E
R
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
----
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
V
K
N
-------
G
------
G
W
T
S
W
K
PLW----
L
C
G
Y
-
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
Y
T
G
R
Q
P
R
P
E
E
A
A
E
F
Q
A
E
-
F
-
V
S
----
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
-
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
-
L
P
T--
N
-----
H
--
P
L
L
-
T
L
K
N
C
V
I
L
P
H
I
G
----
S
A
T
H
R
T
R
N
T
M
S
-
L
L
A
A
N
N
L
L
A
G
L
R
G
E
P
M
P
S
E
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
71.56
34%
-97
- C2 -
1PSD
1
SERA_ECOLI
A:
[9-331]
--
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
--
R
A
A
G
Y
T
N
I
E
F
---
H
K
---
G
A
L
--
D
D
E
Q
L
K
E
S
I
R
D
A
H
F
I
G
L
R
S
R
T
H
L
T
E
D
V
I
N
A
A
-
E
K
L
V
A
I
G
C
F
C
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
----
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
-------
G
------
V
W
N
K
L
A
-------
A
G
S
F
-
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
-----
Y
F
Y
D
I
E
-
N
K
-
L
P
L
G
-
N
-
A
T
Q
V
QH
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
-
K
P
G
S
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
C
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
F
P
T
E
P
-
A
T
---
N
S
D
P
F
T
S
--
P
L
C
E
F
-
D
N
V
L
L
T
P
H
I
G
----
G
S
T
Q
E
A
Q
E
N
I
G
-
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
E
V
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
71.26
34%
-106
- C2 -
2DBQ
8
GYAR_PYRHO
A:
[4-309]
----
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
--
E
D
--
E
F
E
V
E
V
W
G
D
E
K
---
E
-
I
--
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
----
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
-------
G
------
E
W
K
K
R
G
VAWHPKW
F
L
G
Y
-
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
I
L
Y
Y
S
R
T
R
K
E
E
V
-
E
R
E
L
N
A
E
-
F
-
K
P
----
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
-
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
---
N
-----
E
--
E
L
F
K
L
-
D
N
V
V
L
T
P
H
I
G
----
S
A
S
F
G
A
R
E
G
M
A
-
E
L
V
A
K
N
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
70.83
34%
-102
- C2 -
2P9G
1
SERA_ECOLI
A:
[10-332]
--
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
--
R
A
A
G
Y
T
N
I
E
F
---
H
K
---
G
A
L
--
D
D
E
Q
L
K
E
S
I
R
D
A
H
F
I
G
L
R
S
R
T
H
L
T
E
D
V
I
N
A
A
-
E
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
----
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
-------
G
------
V
W
N
K
L
A
-------
A
G
S
F
-
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
-----
Y
F
Y
D
I
E
-
N
K
-
L
P
L
G
-
N
-
A
T
Q
V
QH
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
-
K
P
G
S
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
F
P
T
E
P
-
A
T
---
N
S
D
P
F
T
S
--
P
L
A
E
F
-
D
N
V
L
L
T
P
H
I
G
----
G
S
T
Q
E
A
Q
E
N
I
G
-
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
E
V
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
70.80
34%
-103
- C2 -
2P9C
1
SERA_ECOLI
A:
[10-332]
--
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
--
R
A
A
G
Y
T
N
I
E
F
---
H
K
---
G
A
L
--
D
D
E
Q
L
K
E
S
I
R
D
A
H
F
I
G
L
R
S
R
T
H
L
T
E
D
V
I
N
A
A
-
E
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
----
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
-------
G
------
V
W
N
K
L
A
-------
A
G
S
F
-
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
-----
Y
F
Y
D
I
E
-
N
K
-
L
P
L
G
-
N
-
A
T
Q
V
QH
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
-
K
P
G
S
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
F
P
T
E
P
-
A
T
---
N
S
D
P
F
T
S
--
P
L
A
E
F
-
D
N
V
L
L
T
P
H
I
G
----
G
S
T
Q
E
A
Q
E
N
I
G
-
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
E
V
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
70.72
34%
-100
- C2 -
2P9C
1
SERA_ECOLI
B:
[10-332]
--
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
--
R
A
A
G
Y
T
N
I
E
F
---
H
K
---
G
A
L
--
D
D
E
Q
L
K
E
S
I
R
D
A
H
F
I
G
L
R
S
R
T
H
L
T
E
D
V
I
N
A
A
-
E
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
----
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
-------
G
------
V
W
N
K
L
A
-------
A
G
S
F
-
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
-----
Y
F
Y
D
I
E
-
N
K
-
L
P
L
G
-
N
-
A
T
QVQH
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
-
K
P
G
S
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
F
P
T
E
P
-
A
T
---
N
SDPFT
S
--
P
L
A
E
F
-
D
N
V
L
L
T
P
H
I
G
----
G
S
T
Q
E
A
Q
E
N
I
G
-
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
E
V
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
70.68
34%
-99
- C2 -
2PA3
1
SERA_ECOLI
A:
[10-332]
--
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
--
R
A
A
G
Y
T
N
I
E
F
---
H
K
---
G
A
L
--
D
D
E
Q
L
K
E
S
I
R
D
A
H
F
I
G
L
R
S
R
T
H
L
T
E
D
V
I
N
A
A
-
E
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
----
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
-------
G
------
V
W
N
K
L
A
-------
A
G
S
F
-
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
-----
Y
F
Y
D
I
E
-
N
K
-
L
P
L
G
-
N
-
A
T
Q
V
Q
H
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
-
K
P
G
S
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
F
P
T
E
P
-
A
T
---
N
S
D
P
F
T
S
--
P
L
A
E
F
-
D
N
V
L
L
T
P
H
I
G
----
G
S
T
Q
E
A
Q
E
N
I
G
-
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
E
V
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
70.63
34%
-98
- C2 -
1PSD
1
SERA_ECOLI
B:
[9-331]
--
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
--
R
A
A
G
Y
T
N
I
E
F
---
H
K
---
G
A
L
--
D
D
E
Q
L
K
E
S
I
R
D
A
H
F
I
G
L
R
S
R
T
H
L
T
E
D
V
I
N
A
A
-
E
K
L
V
A
I
G
C
F
C
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
----
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
-------
G
------
V
W
N
K
L
A
-------
A
G
S
F
-
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
-----
Y
F
Y
D
I
E
-
N
K
-
L
P
L
G
-
N
-
A
T
QVQH
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
-
K
P
G
S
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
C
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
F
P
T
E
P
-
A
T
---
N
SDPFT
S
--
P
L
C
E
F
-
D
N
V
L
L
T
P
H
I
G
----
G
S
T
Q
E
A
Q
E
N
I
G
-
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
E
V
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
70.51
34%
-96
- C2 -
2P9G
1
SERA_ECOLI
B:
[10-332]
--
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
--
R
A
A
G
Y
T
N
I
E
F
---
H
K
---
G
A
L
--
D
D
E
Q
L
K
E
S
I
R
D
A
H
F
I
G
L
R
S
R
T
H
L
T
E
D
V
I
N
A
A
-
E
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
----
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
-------
G
------
V
W
N
K
L
A
-------
A
G
S
F
-
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
-----
Y
F
Y
D
I
E
-
N
K
-
L
P
L
G
-
N
-
A
T
QVQH
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
-
K
P
G
S
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
F
P
T
E
P
-
A
T
---
N
SDPFT
S
--
P
L
A
E
F
-
D
N
V
L
L
T
P
H
I
G
----
G
S
T
Q
E
A
Q
E
N
I
G
-
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
E
V
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
65.15
34%
-90
- C2 -
1MX3
2
CTBP1_HUMAN
A:
[37-333]
----------
P
I
L
K
D
V
A
T
V
A
--
F
C
D
A
Q
S
T
Q
E
I
---
H
E
---
K
-
V
--
L
N
E
A
V
G
A
L
M
--
Y
H
T
I
------
T
L
T
R
E
D
L
E
K
F
-
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
----
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
A
T
W
L
H
Q
A
L
R
E
-------
G
T
R
V
Q
S
V
E
Q
I
R
E
V
-------
A
S
G
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
V
L
F
Y
D
P
Y
L
S
D
G
V
-
E
R
A
L
G
L
Q
-
R
V
S
T
----
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
-
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
---
F
-----
S
QG
P
L
K
D
A
-
P
N
L
I
C
T
P
H
A
A
WYS
E
Q
A
S
I
E
M
R
E
E
A
A
-
R
E
I
R
R
A
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
62.83
33%
-89
- C2 -
3GA0
2
CTBP1_RAT
A:
[34-336]
----
D
C
T
V
E
M
P
I
L
K
D
V
A
T
V
A
--
F
C
D
A
Q
S
T
Q
E
I
---
H
E
---
K
-
V
--
L
N
E
A
V
G
A
L
M
--
Y
H
T
I
------
T
L
T
R
E
D
L
E
K
F
-
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
----
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
T
T
W
L
H
Q
A
L
R
E
G
T
R
V
Q
S
V
E
------
Q
I
R
E
V
A
-------
S
G
A
A
-
R
I
R
G
E
T
L
G
I
I
G
L
E
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
V
L
F
Y
D
P
Y
L
S
D
G
I
-
E
R
A
L
G
L
Q
-
R
V
S
T
----
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
-
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
---
F
-----
S
QG
P
L
K
D
A
-
P
N
L
I
C
T
P
H
A
A
WYS
E
Q
A
S
I
E
M
R
E
E
A
A
-
R
E
I
R
R
A
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
62.26
33%
-84
- C2 -
1HKU
4
CTBP1_RAT
A:
[40-336]
----------
P
I
L
K
D
V
A
T
V
A
--
F
C
D
A
Q
S
T
Q
E
I
---
H
E
---
K
-
V
--
L
N
E
A
V
G
A
L
M
--
Y
H
T
I
------
T
L
T
R
E
D
L
E
K
F
-
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
----
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
T
T
W
L
H
Q
A
L
R
E
G
T
R
V
Q
S
V
E
------
Q
I
R
E
V
A
-------
S
G
A
A
-
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
V
L
F
Y
D
P
Y
L
S
D
G
I
-
E
R
A
L
G
L
Q
-
R
V
S
T
----
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
-
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
---
F
-----
S
QG
P
L
K
D
A
-
P
N
L
I
C
T
P
H
A
A
WYS
E
Q
A
S
I
E
M
R
E
E
A
A
-
R
E
I
R
R
A
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
62.09
31%
-98
- C2 -
2CUK
1
?
C:
[12-296]
-----------------
K
A
L
DR
L
R
E
R
G
L
E
V
E
V
---
H
R
---
G
-
L
FL
P
K
A
E
L
L
K
R
V
E
G
A
V
G
L
I
P
T
V
E
D
R
I
D
A
E
V
M
D
R
A
-
K
G
L
K
V
I
A
C
Y
S
V
G
V
D
H
V
D
L
E
A
A
R
E
R
G
I
R
V
T
H
T
P
GVLT
E
A
T
A
D
L
T
L
A
L
L
L
A
V
A
R
R
V
V
E
G
A
A
Y
A
R
D
G
L
W
--------
K
------
A
W
H
P
E
L
-------
L
L
G
L
-
D
L
Q
G
L
T
L
G
L
V
G
M
G
R
I
G
Q
A
V
A
K
R
A
L
A
F
G
M
R
V
V
Y
H
A
-----
R
T
-
P
K
P
L
P
Y
P
-
F
-
L
S
----
L
E
E
L
L
K
E
A
D
V
V
S
L
H
T
P
L
T
P
E
T
H
R
L
L
N
R
E
R
L
F
A
M
-
K
R
G
A
I
L
L
N
T
A
R
G
A
L
V
D
T
E
A
L
V
E
A
L
-
R
G
H
L
F
G
A
G
L
D
V
T
D
P
E
P
L
P
P
---
G
-----
H
--
P
L
Y
A
L
-
P
N
A
V
I
T
P
H
I
G
----
S
A
G
R
T
T
R
E
R
M
A
E
V
A
V
E
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------