@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1606: (2016-03-27 )
MEVKTFYNGNTMPQIGLGTFRVENDENCMESVKYAIEQGYRSIDTAKVYGNEEQVGAGIRAGLESTGIAREDLFITSKLYFEDFGRENVAAAYEASLSRLGLKYLDLYLVHWPGTNEAVMVDTWKGMEDLYKNNKAKNIGVSNFEPEHLEALLAQVSIKPVINQVEYHPYLTQHKLKLYLAAQHIVMESWSPLMNAQILNDETIKDIAQELGKSPAQVVLRWNVQHGVVIIPKSVTPNRISENFQIFDFELSDEQMTRIDGLNQDKRIGPDPKTFEG
Atome Classification :
(68 SA)
......-.-..10---........20--..--..--.....30........40........50........60..-..--....70........80........90........100.......110-.---------------.------------------.------------------.--------------------.------------------..------120------------.------.......130.......140.......150...--.--..--.--160.......170.......180.......190.----------..---.--.-----------.-------.----------200------.........210.......220....----...230.......240.......250---.......260.-......270......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
V
K
T
F-Y-NGNT---M
P
Q
IG
L
G
T
F
---
R
V--EN--
D
E
N
C
M
E
S
V
K
Y
A
I
E
Q
G
Y
RSIDTAKVYG
N
E
E
Q
V
G
A
G
I
R
AG
L
-
E
S--TGIARE
D
L
F
I
T
S
K
L
Y
F
E
DFGR
E
N
V
A
A
A
Y
E
A
S
L
S
R
L
G
L
K
Y
L
D
L
Y
L
V
HW-P---------------G------------------T------------------N--------------------
E
------------------
A
V
------
M
V
-------------D------TWK
G
M
E
D
L
Y
KNNKAKNIGVSNF
E
P
E
H
L
E
A
L
L
A
Q
--
V
--
S
I
--
K
--
P
V
I
N
QVEYHP
Y
L
T
Q
H
K
L
K
L
Y
L
A
A
Q
H
I
V
M
E
SWSPL----------M
N
---
A
--Q-----------I-------L----------
N
--------
D
E
T
I
K
D
I
A
Q
E
LGKSP
A
Q
V
V
L
R
W
NVQH----
G
V
V
I
I
PKSVTPNRISEN
F
Q
I
F
D
F
ELS---D
E
Q
M
T
R
IDGLN-QDKRIGPD-PKTFEG
3
PsiBlast_PDB
96.42
54%
-79
- C7 -
3B3D
1
YTBE_BACSU
A:
[44-313]
----
T
L
-
H
-
N
G
V
E
---
M
P
W
F
G
L
G
V
F
---
Q
V
--
E
E
--
G
S
E
L
V
N
A
V
K
T
A
I
V
H
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
R
E
G
I
-
E
E
--
A
G
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
-
P
-----------------------------------------------------
V
--------------------
E
------------------
G
K
------
Y
K
-------------
E
------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
T
A
--
A
--
E
I
--
K
--
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
L
----------
M
Q
---
G
--
Q
-----------
L
-------
L
----------
D
--------
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
----
G
I
I
T
I
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
---
Q
D
D
M
N
R
I
D
A
L
N
-
E
N
L
R
V
G
P
D
-
P
D
N
F
D
-
23
PsiBlast_CBE
95.69
54%
-78
- C7 -
3B3D
1
YTBE_BACSU
C:
[44-313]
----
T
L
-
H
-
N
G
V
E
---
M
P
W
F
G
L
G
V
F
---
Q
V
--
E
E
--
G
S
E
L
V
N
A
V
K
T
A
I
V
H
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
R
E
G
I
-
E
E
--
A
G
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
-
P
-----------------------------------------------------
V
--------------------
E
------------------
G
K
------
Y
K
-------------
E
------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
T
A
--
A
--
E
I
--
K
--
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
L
----------
M
Q
---
G
--
Q
-----------
L
-------
L
----------
D
--------
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
----
G
I
I
T
I
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
---
Q
D
D
M
N
R
I
D
A
L
N
-
E
N
L
R
V
G
P
D
-
P
D
N
F
D
-
24
PsiBlast_CBE
95.68
54%
-82
- C7 -
3B3D
1
YTBE_BACSU
B:
[44-313]
----
T
L
-
H
-
N
G
V
E
---
M
P
W
F
G
L
G
V
F
---
Q
V
--
E
E
--
G
S
E
L
V
N
A
V
K
T
A
I
V
H
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
R
E
G
I
-
E
E
--
A
G
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
-
P
-----------------------------------------------------
V
--------------------
E
------------------
G
K
------
Y
K
-------------
E
------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
T
A
--
A
--
E
I
--
K
--
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
L
----------
M
Q
---
G
--
Q
-----------
L
-------
L
----------
D
--------
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
----
G
I
I
T
I
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
---
Q
D
D
M
N
R
I
D
A
L
N
-
E
N
L
R
V
G
P
D
-
P
D
N
F
D
-
115
HHSearch
95.37
54%
-77
- C7 -
3B3D
1
YTBE_BACSU
A:
[41-312]
--
A
K
A
T
L
H
-
N
G
V
E
---
M
P
W
F
G
L
G
V
F
---
Q
V
--
E
E
--
G
S
E
L
V
N
A
V
K
T
A
I
V
H
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
R
E
G
I
-
E
E
--
A
G
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
-
P
---------------
V
------------------
E
------------------
G
----------------------------------------
K
------
Y
K
-------------
E
------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
T
A
--
A
--
E
I
--
K
--
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
L
----------
M
Q
---
G
--
Q
-----------
L
-------
L
----------
D
--------
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
----
G
I
I
T
I
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
---
Q
D
D
M
N
R
I
D
A
L
N
-
E
N
L
R
V
G
P
D
-
P
D
N
F
--
2
PsiBlast_PDB
93.07
56%
-80
- C7 -
3F7J
7
GR_BACSU
A:
[11-271]
-----
L
-
H
-
N
G
V
E
---
M
P
W
F
G
L
G
V
F
---
K
V
--
E
N
--
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
-----
E
--
S
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
-
P
---------------
G
------------------
K
------------------
D
--------------------
K
--------------------------
Y
K
-------------
D
------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
--
A
--
E
I
--
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
----------
M
Q
---
G
--
Q
-----------
L
-------
L
----------
D
--------
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
----
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
---
Q
E
D
M
D
K
I
D
A
L
N
-
K
D
E
R
V
G
P
N
-
P
-----
22
PsiBlast_CBE
92.81
56%
-79
- C7 -
3F7J
7
GR_BACSU
B:
[11-271]
-----
L
-
H
-
N
G
V
E
---
M
P
W
F
G
L
G
V
F
---
K
V
--
E
N
--
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
-----
E
--
S
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
-
P
---------------
G
------------------
K
------------------
D
--------------------
K
--------------------------
Y
K
-------------
D
------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
--
A
--
E
I
--
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
----------
M
Q
---
G
--
Q
-----------
L
-------
L
----------
D
--------
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
----
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
---
Q
E
D
M
D
K
I
D
A
L
N
-
K
D
E
R
V
G
P
N
-
P
-----
122
HHSearch
92.50
56%
-79
- C7 -
3F7J
7
GR_BACSU
A:
[6-273]
K
D
T
V
K
L
-
H
-
N
G
V
E
---
M
P
W
F
G
L
G
V
F
---
K
V
--
E
N
--
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
E
S
-------
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
-
P
---------------
G
------------------
K
------------------
D
----------------------------------------
K
------
Y
K
-------------
D
------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
--
A
--
E
I
--
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
----------
M
Q
---
G
--
Q
-----------
L
-------
L
----------
D
--------
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
----
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
---
Q
E
D
M
D
K
I
D
A
L
N
-
K
D
E
R
V
G
P
N
-
P
D
E
---
21
PsiBlast_CBE
92.48
56%
-79
- C7 -
3D3F
1
GR_BACSU
B:
[10-270]
-----
L
-
H
-
N
G
V
E
---
M
P
W
F
G
L
G
V
F
---
K
V
--
E
N
--
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
-----
E
--
S
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
-
P
---------------
G
------------------
K
------------------
D
--------------------
K
--------------------------
Y
K
-------------
D
------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
--
A
--
E
I
--
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
----------
M
Q
---
G
--
Q
-----------
L
-------
L
----------
D
--------
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
----
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
---
Q
E
D
M
D
K
I
D
A
L
N
-
K
D
E
R
V
G
P
N
-
P
-----
4
PsiBlast_PDB
92.38
47%
-78
- C7 -
4FZI
1
PGFS_TRYCC
A:
[17-284]
----
T
L
-
H
-
N
S
V
R
---
M
P
Q
L
G
L
G
V
W
---
R
A
--
Q
D
--
G
A
E
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
-----
E
--
S
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
-
P
---------------
G
------------------
K
------------------
K
--------------------
K
--------------------------
F
V
-------------
D
------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
--
C
--
K
I
--
R
--
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
----------
G
S
GEE
A
--
G
-----------
I
-------
L
----------
K
--------
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
----
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
---
E
E
E
M
R
Q
I
D
E
L
N
-
E
D
K
R
I
G
A
D
-
P
D
N
F
--
5
PsiBlast_PDB
91.89
47%
-78
- C7 -
4GIE
2
PGFS_TRYCC
A:
[17-284]
----
T
L
-
H
-
N
S
V
R
---
M
P
Q
L
G
L
G
V
W
---
R
A
--
Q
D
--
G
A
E
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
-----
E
--
S
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
-
P
---------------
G
------------------
K
------------------
K
--------------------
K
--------------------------
F
V
-------------
D
------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
--
C
--
K
I
--
R
--
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
----------
G
S
GEE
A
--
G
-----------
I
-------
L
----------
K
--------
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
----
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
---
E
E
E
M
R
Q
I
D
E
L
N
-
E
D
K
R
I
G
A
D
-
P
D
N
F
--
1
PsiBlast_PDB
91.51
56%
-78
- C7 -
3D3F
1
GR_BACSU
A:
[10-270]
-----
L
-
H
-
N
G
V
E
---
M
P
W
F
G
L
G
V
F
---
K
V
--
E
N
--
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
-----
E
--
S
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
-
P
---------------
G
------------------
K
------------------
D
--------------------
K
--------------------------
Y
K
-------------
D
------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
--
A
--
E
I
--
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
----------
M
Q
---
G
--
Q
-----------
L
-------
L
----------
D
--------
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
----
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
---
Q
E
D
M
D
K
I
D
A
L
N
-
K
D
E
R
V
G
P
N
-
P
-----
25
PsiBlast_CBE
91.30
47%
-79
- C7 -
4FZI
2
PGFS_TRYCC
B:
[17-284]
----
T
L
-
H
-
N
S
V
R
---
M
P
Q
L
G
L
G
V
W
---
R
A
--
Q
D
--
G
A
E
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
-----
E
--
S
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
-
P
---------------
G
------------------
K
------------------
K
--------------------
K
--------------------------
F
V
-------------
D
------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
--
C
--
K
I
--
R
--
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
----------
G
S
------------------
I
-------
L
----------
K
--------
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
----
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
---
E
E
E
M
R
Q
I
D
E
L
N
-
E
D
K
R
I
G
A
D
-
P
D
N
F
--
28
PsiBlast_CBE
90.12
45%
-85
- C7 -
4F40
10
PGFS_LEIMA
B:
[14-283]
----
T
L
-
S
-
N
G
V
K
---
M
P
Q
F
G
L
G
V
W
---
Q
S
--
P
A
--
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
-------
S
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
-
P
---------------
R
------------------
G
------------------
K
--------------------
D
------------------
I
L
SKEGKK
Y
L
-------------
D
------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
--
C
--
T
V
--
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
----------
G
-------
K
-----------
L
-------
L
----------
S
--------
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
----
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
---
A
E
D
V
M
S
I
D
A
L
N
-
T
N
S
R
Y
G
P
D
-
P
-----
27
PsiBlast_CBE
89.50
45%
-81
- C7 -
4G5D
1
PGFS_LEIMA
B:
[14-283]
----
T
L
-
S
-
N
G
V
K
---
M
P
Q
F
G
L
G
V
W
---
Q
S
--
P
A
--
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
-------
S
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
-
P
---------------
R
------------------
G
------------------
K
--------------------
D
------------------
I
L
S
K
EGKK
Y
L
-------------
D
------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
--
C
--
T
V
--
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
----------
G
Q
---
G
--
K
-----------
L
-------
L
----------
S
--------
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
----
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
---
A
E
D
V
M
S
I
D
A
L
N
-
T
N
S
R
Y
G
P
D
-
P
-----
8
PsiBlast_PDB
89.03
45%
-84
- C7 -
4G5D
1
PGFS_LEIMA
A:
[14-283]
----
T
L
-
S
-
N
G
V
K
---
M
P
Q
F
G
L
G
V
W
---
Q
S
--
P
A
--
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
-------
S
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
-
P
---------------
R
------------------
G
------------------
K
--------------------
D
------------------
I
L
S
K
EGKK
Y
L
-------------
D
------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
--
C
--
T
V
--
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
----------
G
Q
---
G
--
K
-----------
L
-------
L
----------
S
--------
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
----
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
---
A
E
D
V
M
S
I
D
A
L
N
-
T
N
S
R
Y
G
P
D
-
P
-----
40
PsiBlast_CBE
88.88
44%
-84
- C7 -
4Q3M
1
?
C:
[8-265]
---------
N
N
Y
E
---
M
P
I
I
G
L
G
T
F
---
R
S
--
K
K
--
N
D
-
A
Y
N
A
V
K
A
A
L
E
G
G
Y
R
H
I
D
T
A
M
I
Y
G
N
E
E
E
V
G
R
A
I
K
-----
D
--
S
N
I
P
R
E
E
I
F
V
T
T
K
L
W
N
T
D
Q
G
Y
E
K
T
L
E
A
F
N
T
S
L
K
N
L
G
L
D
Y
I
D
L
Y
L
I
H
W
F
K
---------------
G
------------------
Y
------------------
D
--------------------
N
------------------
A
L
---------------------
S
------
T
Y
R
A
F
E
T
L
Y
E
E
G
K
V
K
A
I
G
V
S
N
F
N
V
H
H
L
M
Y
L
M
E
N
--
A
--
K
I
--
P
--
P
M
V
N
Q
V
E
T
H
V
T
L
Q
N
H
F
L
H
D
Y
C
K
K
N
N
I
Q
L
E
A
Y
A
P
L
----------
M
S
---
H
--
Q
-----------
I
K
D
L
----
L
----------
S
--------
N
E
T
M
A
K
I
A
K
K
H
D
K
T
I
P
Q
I
A
I
R
W
L
I
E
R
----
E
I
V
V
I
P
K
S
I
T
P
E
R
I
V
Q
N
F
D
V
F
D
F
T
L
D
---
E
E
D
M
K
S
I
R
S
V
N
-
T
G
K
K
I
----------
120
HHSearch
88.54
44%
-82
- C7 -
1US0
4
ALDR_HUMAN
A:
[1-301]
M
A
S
R
I
L
-
L
N
N
G
A
K
---
M
P
I
L
G
L
G
T
W
---
K
S
--
P
---
P
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
Q
E
K
L
-
R
E
--
Q
V
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
-
P
---------------
T
------------------
G
------------------
F
--------------------
K
PGKEF
F
P
L
D
ESGNVVPSD
T
N
------
I
L
-------------
D
------
T
W
A
A
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
N
H
L
Q
V
E
M
I
L
N
K
--
P
GL
K
Y
--
K
--
P
A
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
----------
G
S
---
P
--
D
-----------
R
-------
P
WAKPEDPSLL
E
--------
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
----
N
L
V
V
I
P
K
S
V
T
P
E
R
I
A
E
N
F
K
V
F
D
F
E
L
S
---
S
Q
D
M
T
T
L
L
S
Y
N
-
R
N
W
R
V
C
A
L
-------
7
PsiBlast_PDB
88.50
45%
-82
- C7 -
4F40
11
PGFS_LEIMA
A:
[14-283]
----
T
L
-
S
-
N
G
V
K
---
M
P
Q
F
G
L
G
V
W
---
Q
S
--
P
A
--
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
-------
S
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
-
P
---------------
R
------------------
G
------------------
K
--------------------
D
------------------
I
L
S
K
EGKK
Y
L
-------------
D
------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
--
C
--
T
V
--
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
----------
G
-------
K
-----------
L
-------
L
----------
S
--------
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
----
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
---
A
E
D
V
M
S
I
D
A
L
N
-
T
N
S
R
Y
G
P
D
-
P
-----
111
HHSearch
88.27
41%
-78
- C7 -
2WZM
1
Y2407_MYCS2
A:
[11-282]
I
P
T
V
T
L
-
N
-
D
D
N
T
---
L
P
V
V
G
I
G
V
G
---
E
L
--
S
---
D
S
E
A
E
R
S
V
S
A
A
L
E
A
G
Y
R
L
I
D
T
A
A
A
Y
G
N
E
A
A
V
G
R
A
I
A
A
S
-------
G
I
P
R
D
E
I
Y
V
T
T
K
L
A
T
P
D
Q
G
F
T
S
S
Q
A
A
A
R
A
S
L
E
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
-
P
---------------
G
------------------
G
------------------
D
--------------------
T
------------------
S
K
------
Y
V
-------------
D
------
S
W
G
G
L
M
K
V
K
E
D
G
I
A
R
S
I
G
V
C
N
F
G
A
E
D
L
E
T
I
V
S
L
--
T
--
Y
F
--
T
--
P
A
V
N
Q
I
E
L
H
P
L
L
N
Q
A
A
L
R
E
V
N
A
G
Y
N
I
V
T
E
A
Y
G
P
L
----------
G
V
---
G
--
R
-----------
L
-------
L
----------
D
--------
H
P
A
V
T
A
I
A
E
A
H
G
R
T
A
A
Q
V
L
L
R
W
S
I
Q
L
----
G
N
V
V
I
S
R
S
A
N
P
E
R
I
A
S
N
L
D
V
F
G
F
E
L
T
---
A
D
E
M
E
T
L
N
G
L
D
-
D
G
T
R
F
R
P
D
-
P
A
T
Y
T
G
52
PsiBlast_CBE
88.17
36%
-88
- C7 -
3FX4
5
AK1A1_PIG
A:
[8-298]
-----
L
-
H
-
T
G
Q
K
---
M
P
L
I
G
L
G
T
W
---
K
S
--
E
P
--
G
Q
-
V
K
A
A
I
K
Y
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
Q
E
T
V
G
P
G
--
K
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
-
P
Y
A
F
ERGDNP
F
P
K
N
AD
G
------------------
T
I
R
Y
---------------
D
--------------------
A
------------------
T
H
------
Y
K
-------------
D
------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
--
A
--
S
V
--
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
----------
G
S
---
S
--
D
RAWRDPNEPV-
L
-------
L
----------
E
--------
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
----
K
V
I
C
I
P
K
S
V
T
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
---
P
E
E
M
K
Q
L
D
A
L
N
-
K
N
L
R
F
----------
53
PsiBlast_CBE
87.48
36%
-89
- C7 -
3CV7
5
AK1A1_PIG
A:
[8-301]
-----
L
-
H
-
T
G
Q
K
---
M
P
L
I
G
L
G
T
W
---
K
S
--
E
P
--
G
Q
-
V
K
A
A
I
K
Y
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
Q
E
T
V
G
P
G
--
K
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
-
P
Y
A
F
ERGDNP
F
P
K
N
AD
G
------------------
T
I
R
Y
---------------
D
--------------------
A
------------------
T
H
------
Y
K
-------------
D
------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
--
A
--
S
V
--
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
----------
G
S
---
S
--
D
RAWRDPNEPV-
L
-------
L
----------
E
--------
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
----
K
V
I
C
I
P
K
S
V
T
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
---
P
E
E
M
K
Q
L
D
A
L
N
-
K
N
L
R
F
----------
42
PsiBlast_CBE
87.13
41%
-87
- C7 -
4JII
3
AK1BA_HUMAN
X:
[15-299]
----------------
M
P
I
V
G
L
G
T
W
---
K
S
--
P
L
--
G
K
-
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
E
K
I
-
Q
E
--
K
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
-
P
---------------
Q
GFKSGDDLFPKDDKGNAI
G
------------------
G
--------------------
K
------------------
A
T
------
F
L
-------------
D
------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
PG
L
--
K
Y
--
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
GSPDRPWAKP
E
D
---
P
--
S
-----------
L
-------
L
----------
E
--------
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
----
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
---
D
E
E
M
A
T
I
L
S
F
N
-
R
N
W
R
-----------
18
PsiBlast_PDB
86.89
41%
-89
- C7 -
4I5X
2
AK1BA_HUMAN
A:
[15-299]
----------------
M
P
I
V
G
L
G
T
W
---
K
S
--
P
L
--
G
K
-
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
E
K
I
-
Q
E
--
K
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
-
P
---------------
Q
G
F
KSGDDLFPKDDKG
N
A
I
G
------------------
G
--------------------
K
------------------
A
T
------
F
L
-------------
D
------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
PG
L
--
K
Y
--
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
GSPDRPWAKP
E
D
---
P
--
S
-----------
L
-------
L
----------
E
--------
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
----
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
---
D
E
E
M
A
T
I
L
S
F
N
-
R
N
W
R
-----------
46
PsiBlast_CBE
86.88
41%
-87
- C7 -
4GA8
2
AK1BA_HUMAN
A:
[13-297]
----------------
M
P
I
V
G
L
G
T
W
---
K
S
--
P
L
--
G
K
-
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
E
K
I
-
Q
E
--
K
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
-
P
---------------
Q
G
F
KSGDDL
F
P
K
D
DKG
N
A
I
G
------------------
G
--------------------
K
------------------
A
T
------
F
L
-------------
D
------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
PG
L
--
K
Y
--
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
GSPDRPWAKP
E
D
---
P
--
S
-----------
L
-------
L
----------
E
--------
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
----
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
---
D
E
E
M
A
T
I
L
S
F
N
-
R
N
W
R
-----------
19
PsiBlast_PDB
86.73
41%
-86
- C7 -
1ZUA
2
AK1BA_HUMAN
X:
[14-298]
----------------
M
P
I
V
G
L
G
T
W
---
K
S
--
P
L
--
G
K
-
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
E
K
I
-
Q
E
--
K
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
-
P
---------------
Q
GFKSGDDLFPKDDKGNAI
G
------------------
G
--------------------
K
------------------
A
T
------
F
L
-------------
D
------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
PG
L
--
K
Y
--
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
GSPDRPWAKP
E
D
---
P
--
S
-----------
L
-------
L
----------
E
--------
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
----
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
---
D
E
E
M
A
T
I
L
S
F
N
-
R
N
W
R
-----------
54
PsiBlast_CBE
86.68
36%
-83
- C7 -
1HQT
1
AK1A1_PIG
A:
[9-299]
-----
L
-
H
-
T
G
Q
K
---
M
P
L
I
G
L
G
T
W
---
K
S
--
E
P
--
G
Q
-
V
K
A
A
I
K
Y
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
F
G
N
E
L
E
I
G
E
A
L
Q
E
T
V
G
P
G
--
K
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
-
P
Y
A
F
ERGDNP
F
P
K
N
AD
G
------------------
T
IR
Y
---------------
D
--------------------
A
------------------
T
H
------
Y
K
-------------
D
------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
--
A
--
S
V
--
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
----------
G
S
---
S
--
D
RA
W
R
D
P
N
E
PV-
L
-------
L
----------
E
--------
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
----
K
V
I
C
I
P
K
S
V
T
P
S
R
I
P
Q
N
I
Q
V
F
D
F
T
F
S
---
P
E
E
M
K
Q
L
D
A
L
N
-
K
N
L
R
F
----------
44
PsiBlast_CBE
86.37
41%
-88
- C7 -
4JIH
2
AK1BA_HUMAN
A:
[15-299]
----------------
M
P
I
V
G
L
G
T
W
---
K
S
--
P
L
--
G
K
-
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
E
K
I
-
Q
E
--
K
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
-
P
---------------
Q
GFKSGDDL
F
P
K
D
DKG
N
A
I
G
------------------
G
--------------------
K
------------------
A
T
------
F
L
-------------
D
------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
PG
L
--
K
Y
--
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
GSPDRPWAKP
E
D
---
P
--
S
-----------
L
-------
L
----------
E
--------
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
----
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
---
D
E
E
M
A
T
I
L
S
F
N
-
R
N
W
R
-----------
51
PsiBlast_CBE
86.24
36%
-88
- C7 -
3H4G
3
AK1A1_PIG
A:
[8-302]
-----
L
-
H
-
T
G
Q
K
---
M
P
L
I
G
L
G
T
W
---
K
S
--
E
P
--
G
Q
-
V
K
A
A
I
K
Y
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
Q
E
T
V
G
P
G
--
K
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
-
P
Y
A
F
E
RGDNP
F
P
K
N
AD
G
------------------
T
IRY---------------
D
--------------------
A
------------------
T
H
------
Y
K
-------------
D
------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
--
A
--
S
V
--
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
----------
G
S
---
S
--
D
RAWRDPNEPV-
L
-------
L
----------
E
--------
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
----
K
V
I
C
I
P
K
S
V
T
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
---
P
E
E
M
K
Q
L
D
A
L
N
-
K
N
L
R
F
----------
55
PsiBlast_CBE
86.12
36%
-90
- C7 -
4GAC
2
AK1A1_MOUSE
B:
[7-303]
-----
L
-
H
-
T
G
Q
K
---
M
P
L
I
G
L
G
T
W
---
K
S
--
E
P
--
G
Q
-
V
K
A
A
I
K
H
A
L
S
A
G
Y
R
H
I
D
C
A
S
V
Y
G
N
E
T
E
I
G
E
A
L
K
E
S
V
-
G
S
G-
K
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
-
P
Y
A
F
E
RGDNPFPK---
G
------------------
T
VRY---------------
D
--------------------
S
------------------
T
H
------
Y
K
-------------
E
------
T
W
K
A
L
E
V
L
V
A
K
G
L
V
K
A
L
G
L
S
N
F
N
S
R
Q
I
D
D
V
L
S
V
--
A
--
S
V
--
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
H
A
R
G
L
E
V
T
A
Y
S
P
L
----------
G
--------PDEPV------
L
-------
L
----------
E
--------
E
P
V
V
L
A
L
A
E
K
H
G
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
----
K
V
I
C
I
P
K
S
I
N
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
---
P
E
E
M
K
Q
L
D
A
L
N
-
K
N
W
R
-----------
112
HHSearch
85.90
44%
-76
- C7 -
1VBJ
2
PGFS_TRYBB
A:
[10-278]
-
Q
S
L
K
L
-
S
-
N
G
V
M
---
M
P
V
L
G
F
G
M
W
---
K
L
--
Q
D
--
G
N
E
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
A
S
C
-------
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
-
P
---------------
G
------------------
K
------------------
D
----------------------------------------
K
------
F
I
-------------
D
------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
--
C
--
K
V
--
A
--
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
----------
G
Q
---
G
--
H
-----------
L
-------
V
----------
E
--------
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
----
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
---
A
E
D
I
Q
V
I
D
G
M
N
-
A
G
H
R
Y
G
P
D
-
P
E
V
F
M
-
43
PsiBlast_CBE
85.90
41%
-86
- C7 -
4GQG
1
AK1BA_HUMAN
A:
[15-299]
----------------
M
P
I
V
G
L
G
T
W
---
K
S
--
P
L
--
G
K
-
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
E
K
I
-
Q
E
--
K
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
-
P
---------------
Q
GFKSGDDL
F
P
K
D
DKG
N
A
I
G
------------------
G
--------------------
K
------------------
A
T
------
F
L
-------------
D
------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
PG
L
--
K
Y
--
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
GSPDRPWAKP
E
D
---
P
--
S
-----------
L
-------
L
----------
E
--------
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
----
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
---
D
E
E
M
A
T
I
L
S
F
N
-
R
N
W
R
-----------
34
PsiBlast_CBE
85.81
43%
-77
- C7 -
3WBW
3
?
B:
[16-279]
--
V
I
S
F
-
H
-
D
G
H
T
---
M
P
Q
I
G
L
G
V
W
---
E
T
--
P
P
--
D
E
T
A
-
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
E
D
H
P
-
E
----------
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
-
P
---------------
M
------------------
P
------------------
A
--------------------
Q
------------------
G
Q
------
Y
V
-------------
E
------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
--
T
--
G
V
--
V
--
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
----------
G
K
---
G
--
R
-----------
V
-------
L
----------
S
--------
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
----
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
---
A
D
D
M
Q
A
I
E
Q
M
D
R
K
D
G
R
M
G
A
D
-
P
N
T
---
45
PsiBlast_CBE
85.75
41%
-85
- C7 -
4GAB
3
AK1BA_HUMAN
A:
[13-297]
----------------
M
P
I
V
G
L
G
T
W
---
K
S
--
P
L
--
G
K
-
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
E
K
I
-
Q
E
--
K
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
-
P
---------------
Q
G
F
KSGDDL
F
P
K
D
DKG
N
A
I
G
------------------
G
--------------------
K
------------------
A
T
------
F
L
-------------
D
------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
PG
L
--
K
Y
--
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
GSPDRPWAKP
E
D
---
P
--
S
-----------
L
-------
L
----------
E
--------
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
----
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
---
D
E
E
M
A
T
I
L
S
F
N
-
R
N
W
R
-----------
6
PsiBlast_PDB
85.64
44%
-74
- C7 -
1VBJ
2
PGFS_TRYBB
A:
[16-277]
---------
N
G
V
M
---
M
P
V
L
G
F
G
M
W
---
K
L
--
Q
D
--
G
N
E
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
-----
A
S
--
C
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
-
P
---------------
G
------------------
K
------------------
D
--------------------
K
--------------------------
F
I
-------------
D
------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
--
C
--
K
V
--
A
--
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
----------
G
Q
---
G
--
H
-----------
L
-------
V
----------
E
--------
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
----
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
---
A
E
D
I
Q
V
I
D
G
M
N
-
A
G
H
R
Y
G
P
D
-
P
E
V
F
--
127
HHSearch
85.58
39%
-82
- C7 -
3H7U
2
AKRC9_ARATH
A:
[25-308]
I
T
F
F
K
L
-
N
-
T
G
A
K
---
F
P
S
V
G
L
G
T
W
---
Q
A
--
S
---
P
G
L
V
G
D
A
V
A
A
A
V
K
I
G
Y
R
H
I
D
C
A
Q
I
Y
G
N
E
K
E
I
G
A
V
L
K
K
L
F
-
E
D
--
R
V
V
K
R
E
D
L
F
I
T
S
K
L
W
C
T
D
H
D
P
Q
D
V
P
E
A
L
N
R
T
L
K
D
L
Q
L
E
Y
V
D
L
Y
L
I
H
W
-
P
---------------
A
------------------
R
------------------
I
--------------------
K
K
GSVGIKPENLLP-----
V
D
------
I
P
-------------
S
------
T
W
K
A
M
E
A
L
Y
D
S
G
K
A
R
A
I
G
V
S
N
F
S
T
K
K
L
A
D
L
L
E
L
--
A
--
R
V
--
P
--
P
A
V
N
Q
V
E
C
H
P
S
W
R
Q
T
K
L
Q
E
F
C
K
S
K
G
V
H
L
S
A
Y
S
P
L
----------
G
S
---
P
--
G
-----------
T
TWLKSDV
L
----------
K
--------
N
P
I
L
N
M
V
A
E
K
L
G
K
S
P
A
Q
V
A
L
R
W
G
L
Q
M
----
G
H
S
V
L
P
K
S
T
N
E
G
R
I
K
E
N
F
N
V
F
D
W
S
I
P
---
D
Y
M
F
A
K
F
A
E
I
E
-
Q
A
-------------
20
PsiBlast_PDB
85.55
41%
-87
- C7 -
4GQ0
2
AK1BA_HUMAN (first)
A:
[15-299]
----------------
M
P
I
V
G
L
G
T
W
---
K
S
--
P
L
--
G
K
-
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
E
K
I
-
Q
E
--
K
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
-
P
---------------
Q
G
F
KSGDDL
F
P
K
D
DKG
N
A
I
G
------------------
G
--------------------
K
------------------
A
T
------
F
L
-------------
D
------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
PG
L
--
K
Y
--
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
GSPDRPWAKP
E
D
---
P
--
S
-----------
L
-------
L
----------
E
--------
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
----
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
---
D
E
E
M
A
T
I
L
S
F
N
-
R
N
W
R
-----------
113
HHSearch
85.26
42%
-85
- C7 -
3O0K
4
?
A:
[26-282]
V
P
T
V
K
L
-
N
-
D
G
N
H
---
I
P
Q
L
G
Y
G
V
W
---
Q
I
--
S
---
N
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
S
-------
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
-
P
---------------
M
------------------
P
------------------
S
--------------------
K
------------------
D
L
------
F
M
-------------
E
------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
--
S
--
G
V
--
T
--
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
----------
G
Q
---
G
--------------
L
-------
L
----------
E
--------
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
----
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
---
G
T
D
H
D
A
I
T
K
L
-----------------
62
PsiBlast_CBE
85.24
41%
-85
- C7 -
1C9W
1
ALD2_CRIGR
A:
[12-303]
----------------
M
P
I
V
G
L
G
T
W
---
Q
S
--
P
P
--
G
Q
-
V
K
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
A
Y
Y
N
E
H
E
V
G
E
A
I
Q
E
K
I
-
K
E
--
K
A
V
R
R
E
D
L
F
I
V
S
K
L
W
P
T
C
F
E
R
K
L
L
K
E
A
F
Q
K
T
L
T
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
-
P
---------------
Q
G
L
Q
P
G
KEL
F
P
K
D
DQG
N
V
L
T
------------------
S
--------------------
K
------------------
I
T
------
F
L
-------------
D
------
A
W
E
V
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
N
H
F
Q
I
E
R
I
L
N
K
--
P
--
G
L
KH
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
E
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
GSPNRPWAKP
E
D
---
P
--
S
-----------
L
-------
L
----------
E
--------
D
P
K
I
K
E
I
A
A
K
H
K
K
T
S
A
Q
V
L
I
R
F
H
I
Q
R
----
N
V
V
V
I
P
K
S
V
T
P
A
R
I
H
E
N
F
Q
V
F
D
F
Q
L
S
---
D
Q
E
M
A
T
I
L
G
F
N
-
R
N
W
R
A
C
L
L
-
P
E
T
---
26
PsiBlast_CBE
85.13
44%
-71
- C7 -
1VBJ
2
PGFS_TRYBB
B:
[16-277]
---------
N
G
V
M
---
M
P
V
L
G
F
G
M
W
---
K
L
--
Q
D
--
G
N
E
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
-----
A
S
--
C
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
-
P
---------------
G
------------------
K
------------------
D
--------------------
K
--------------------------
F
I
-------------
D
------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
--
C
--
K
V
--
A
--
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
----------
G
Q
---
G
--
H
-----------
L
-------
V
----------
E
--------
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
----
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
---
A
E
D
I
Q
V
I
D
G
M
N
-
A
G
H
R
Y
G
P
D
-
P
E
V
F
--
9
PsiBlast_PDB
85.06
44%
-68
- C7 -
1MZR
4
DKGA_ECOLI
A:
[27-296]
--
V
I
K
L
-
Q
-
D
G
N
V
---
M
P
Q
L
G
L
G
V
W
---
Q
A
--
S
N
--
E
E
-
V
I
T
A
I
Q
K
A
L
E
V
G
Y
R
S
I
D
T
A
A
A
Y
K
N
E
E
G
V
G
K
A
----
L
-
K
N
--
A
S
V
N
R
E
E
L
F
I
T
T
K
L
W
N
D
D
H
K
R
P
R
--
E
A
L
L
D
S
L
K
K
L
Q
L
D
Y
I
D
L
Y
L
M
H
W
-
P
---------------
V
------------------
P
------------------
A
--------------------
I
------------------
D
H
------
Y
V
-------------
E
------
A
W
K
G
M
I
E
L
Q
K
E
G
L
I
K
S
I
G
V
C
N
F
Q
I
H
H
L
Q
R
L
I
D
E
--
T
--
G
V
--
T
--
P
V
I
N
Q
I
E
L
H
P
L
M
Q
Q
R
Q
L
H
A
W
N
A
T
H
K
I
Q
T
E
S
W
S
P
L
----------
A
Q
---
G
GK
G
-----------
V
-------
F
----------
D
--------
Q
K
V
I
R
D
L
A
D
K
Y
G
K
T
P
A
Q
I
V
I
R
W
H
L
D
S
----
G
L
V
V
I
P
K
S
V
T
P
S
R
I
A
E
N
F
D
V
W
D
F
R
L
D
---
K
D
E
L
G
E
I
A
K
L
D
-
Q
G
K
R
L
G
P
D
-
P
D
Q
F
G
G
11
PsiBlast_PDB
84.75
43%
-73
- C7 -
3WBW
2
?
A:
[16-279]
--
V
I
S
F
-
H
-
D
G
H
T
---
M
P
Q
I
G
L
G
V
W
---
E
T
--
P
P
--
D
E
T
A
-
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
E
D
H
P
-
E
----------
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
-
P
---------------
M
------------------
P
------------------
A
--------------------
Q
------------------
G
Q
------
Y
V
-------------
E
------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
--
T
--
G
V
--
V
--
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
----------
G
K
---
G
--
R
-----------
V
-------
L
----------
S
--------
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
----
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
---
A
D
D
M
Q
A
I
E
Q
M
D
R
K
D
G
R
M
G
A
D
-
P
N
T
---
32
PsiBlast_CBE
84.62
43%
-88
- C7 -
3O0K
4
?
B:
[33-283]
---------
D
G
N
H
---
I
P
Q
L
G
Y
G
V
W
---
Q
I
--
S
N
--
D
E
-
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
-------
S
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
-
P
---------------
M
------------------
P
------------------
S
--------------------
K
------------------
D
L
------
F
M
-------------
E
------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
--
S
--
G
V
--
T
--
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
----------
G
-------------------
L
-------
L
----------
E
--------
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
----
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
-------------------
56
PsiBlast_CBE
84.40
36%
-83
- C7 -
4GAC
2
AK1A1_MOUSE
A:
[7-296]
-----
L
-
H
-
T
G
Q
K
---
M
P
L
I
G
L
G
T
W
---
K
S
--
E
P
--
G
Q
-
V
K
A
A
I
K
H
A
L
S
A
G
Y
R
H
I
D
C
A
S
V
Y
G
N
E
T
E
I
G
E
A
L
K
E
S
V
-
G
S
G-
K
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
-
P
Y
A
F
ERGDNPFPKNAD
G
------------------
T
V
R
Y
---------------
D
--------------------
S
------------------
T
H
------
Y
K
-------------
E
------
T
W
K
A
L
E
V
L
V
A
K
G
L
V
K
A
L
G
L
S
N
F
N
S
R
Q
I
D
D
V
L
S
V
--
A
--
S
V
--
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
H
A
R
G
L
E
V
T
A
Y
S
P
L
----------
G
S
---
S
--
D
RAWRHPDEPV-
L
-------
L
----------
E
--------
E
P
V
V
L
A
L
A
E
K
H
G
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
----
K
V
I
C
I
P
K
S
I
N
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
---
P
E
E
M
K
Q
L
D
A
L
N
-
K
N
W
R
-----------
13
PsiBlast_PDB
84.38
42%
-74
- C7 -
3WBY
2
?
A:
[16-279]
--
V
I
S
F
-
H
-
D
G
H
T
---
M
P
Q
I
G
L
G
V
W
---
E
T
--
P
P
--
D
E
T
A
-
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
A
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
E
D
H
P
-
E
----------
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
-
P
---------------
M
------------------
P
------------------
A
--------------------
Q
------------------
G
Q
------
Y
V
-------------
E
------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
--
T
--
G
V
--
V
--
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
----------
G
K
---
G
--
R
-----------
V
-------
L
----------
S
--------
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
----
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
---
A
D
D
M
Q
A
I
E
Q
M
D
R
K
D
G
R
M
G
A
D
-
P
N
T
---
10
PsiBlast_PDB
84.32
43%
-85
- C7 -
3O0K
4
?
A:
[33-283]
---------
D
G
N
H
---
I
P
Q
L
G
Y
G
V
W
---
Q
I
--
S
N
--
D
E
-
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
-------
S
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
-
P
---------------
M
------------------
P
------------------
S
--------------------
K
------------------
D
L
------
F
M
-------------
E
------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
--
S
--
G
V
--
T
--
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
----------
G
Q
---
G
--------------
L
-------
L
----------
E
--------
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
----
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
-------------------
118
HHSearch
84.18
44%
-73
- C7 -
1MZR
4
DKGA_ECOLI
A:
[25-296]
P
T
V
I
K
L
-
Q
-
D
G
N
V
---
M
P
Q
L
G
L
G
V
W
---
Q
A
--
S
---
N
E
E
V
I
T
A
I
Q
K
A
L
E
V
G
Y
R
S
I
D
T
A
A
A
Y
K
N
E
E
G
V
G
K
A
L
K
N
A
-------
S
V
N
R
E
E
L
F
I
T
T
K
L
W
N
--
D
D
H
K
R
P
R
E
A
L
L
D
S
L
K
K
L
Q
L
D
Y
I
D
L
Y
L
M
H
W
-
P
---------------
V
------------------
P
------------------
A
--------------------
I
------------------
D
H
------
Y
V
-------------
E
------
A
W
K
G
M
I
E
L
Q
K
E
G
L
I
K
S
I
G
V
C
N
F
Q
I
H
H
L
Q
R
L
I
D
E
--
T
--
G
V
--
T
--
P
V
I
N
Q
I
E
L
H
P
L
M
Q
Q
R
Q
L
H
A
W
N
A
T
H
K
I
Q
T
E
S
W
S
P
L
----------
A
Q
---
G
--
G
-----------
K
GV-----
F
----------
D
--------
Q
K
V
I
R
D
L
A
D
K
Y
G
K
T
P
A
Q
I
V
I
R
W
H
L
D
S
----
G
L
V
V
I
P
K
S
V
T
P
S
R
I
A
E
N
F
D
V
W
D
F
R
L
D
---
K
D
E
L
G
E
I
A
K
L
D
-
Q
G
K
R
L
G
P
D
-
P
D
Q
F
G
G
57
PsiBlast_CBE
84.10
37%
-81
- C7 -
3H7U
2
AKRC9_ARATH
A:
[26-311]
----
T
F
-
F
-
K
L
N
T
GAK
F
P
S
V
G
L
G
T
W
---
Q
A
---
S
--
P
G
L
V
G
D
A
V
A
A
A
V
K
I
G
Y
R
H
I
D
C
A
Q
I
Y
G
N
E
K
E
I
G
A
V
L
K
K
L
F
-
E
D
--
R
V
V
K
R
E
D
L
F
I
T
S
K
L
W
C
T
D
H
D
P
Q
D
V
P
E
A
L
N
R
T
L
K
D
L
Q
L
E
Y
V
D
L
Y
L
I
H
W
-
P
---------------
A
------------------
R
------------------
I
--------------------
K
------------------
K
G
------
S
V
GIKPENLLPVD
I
P
S
------
T
W
K
A
M
E
A
L
Y
D
S
G
K
A
R
A
I
G
V
S
N
F
S
T
K
K
L
A
D
L
L
E
L
--
A
--
R
V
--
P
--
P
A
V
N
Q
V
E
C
H
P
S
W
R
Q
T
K
L
Q
E
F
C
K
S
K
G
V
H
L
S
A
Y
S
P
L
GSPGTTW---
L
K
---
S
--
D
-----------
V
-------
L
----------
K
--------
N
P
I
L
N
M
V
A
E
K
L
G
K
S
P
A
Q
V
A
L
R
W
G
L
Q
M
----
G
H
S
V
L
P
K
S
T
N
E
G
R
I
K
E
N
F
N
V
F
D
W
S
I
P
---
D
Y
M
F
A
K
F
A
E
I
E
-
Q
A
R
L
V
----------
31
PsiBlast_CBE
83.93
43%
-86
- C7 -
3O0K
3
?
C:
[33-283]
---------
D
G
N
H
---
I
P
Q
L
G
Y
G
V
W
---
Q
I
--
S
N
--
D
E
-
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
-------
S
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
-
P
---------------
M
------------------
P
------------------
S
--------------------
K
------------------
D
L
------
F
M
-------------
E
------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
--
S
--
G
V
--
T
--
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
----------
G
-------------------
L
-------
L
----------
E
--------
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
----
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
-------------------
121
HHSearch
83.82
42%
-75
- C7 -
3WBW
2
?
A:
[15-279]
-
T
V
I
S
F
-
H
-
D
G
H
T
---
M
P
Q
I
G
L
G
V
W
---
E
T
--
P
---
P
D
E
T
A
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
E
-----------
D
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
-
P
---------------
M
------------------
P
------------------
A
--------------------
Q
------------------
G
Q
------
Y
V
-------------
E
------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
--
T
--
G
V
--
V
--
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
----------
G
K
---
G
--
R
-----------
V
-------
L
----------
S
--------
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
----
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
---
A
D
D
M
Q
A
I
E
Q
M
D
-
R
K
D
G
R
M
G
A
D
P
N
T
---
69
PsiBlast_CBE
83.79
37%
-82
- C7 -
3UZW
3
AK1D1_HUMAN
B:
[34-328]
---------
D
G
N
S
---
I
P
I
I
G
L
G
T
Y
SEP
K
S
--
T
P
--
K
G
A
C
A
T
S
V
K
V
A
I
D
T
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
-
A
E
--
G
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
-
P
---------------
M
------------------
A
FKPGDEIYPRDENGKWLY
H
--------------------
K
------------------
S
N
------
L
C
-------------
A
------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
--
P
--
G
L
--
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
L
----------
G
T
---
S
--
R
NPIWVNVSSPP
L
-------
L
----------
K
--------
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
----
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
---
E
E
E
M
K
D
I
E
A
L
N
-
K
N
V
R
F
----------
81
PsiBlast_CBE
83.71
37%
-82
- C7 -
4JQ4
7
AK1C2_HUMAN
B:
[12-304]
---------
D
G
H
F
---
M
P
V
L
G
F
G
T
Y
---
A
P
--
A
E
VP
K
S
K
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
-
A
D
--
G
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
-
P
---------------
V
------------------
S
VKPGEEV
I
P
K
D
E------
N
--------------------
G
------------------
K
I
------
L
F
-------------
D
T
V
D
L
C
A
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
PG
L
--
K
Y
--
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
----------
G
S
---
H
---PWVDPNSPV--
L
-------
L
----------
E
--------
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
----
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
-
R
N
V
R
-----------
63
PsiBlast_CBE
83.59
37%
-80
- C7 -
3UZZ
2
AK1D1_HUMAN
B:
[34-328]
---------
D
G
N
S
---
I
P
I
I
G
L
G
T
Y
SEP
K
S
--
T
P
--
K
G
A
C
A
T
S
V
K
V
A
I
D
T
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
-
A
E
--
G
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
-
P
---------------
M
------------------
A
FKPGDEIYPRDENGKWLY
H
--------------------
K
------------------
S
N
------
L
C
-------------
A
------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
--
P
--
G
L
--
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
L
----------
G
T
---
S
--
R
NPIWVNVSSPP
L
-------
L
----------
K
--------
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
----
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
---
E
E
E
M
K
D
I
E
A
L
N
-
K
N
V
R
F
----------
35
PsiBlast_CBE
83.59
42%
-75
- C7 -
3WBY
1
?
B:
[16-279]
--
V
I
S
F
-
H
-
D
G
H
T
---
M
P
Q
I
G
L
G
V
W
---
E
T
--
P
P
--
D
E
T
A
-
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
A
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
E
D
H
P
-
E
----------
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
-
P
---------------
M
------------------
P
------------------
A
--------------------
Q
------------------
G
Q
------
Y
V
-------------
E
------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
--
T
--
G
V
--
V
--
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
----------
G
K
---
G
--
R
-----------
V
-------
L
----------
S
--------
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
----
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
---
A
D
D
M
Q
A
I
E
Q
M
D
R
K
D
G
R
M
G
A
D
-
P
N
T
---
47
PsiBlast_CBE
83.54
40%
-79
- C7 -
1VP5
1
?
B:
[19-276]
----
T
L
-
N
-
N
G
V
E
---
M
P
I
L
G
Y
G
V
F
---
Q
I
PP
E
K
--
T
E
E
C
---
V
Y
E
A
I
K
V
G
Y
R
L
I
D
T
A
A
S
Y
M
N
E
E
G
V
G
R
A
I
K
R
A
I
-
D
E
--
G
I
V
R
R
E
E
L
F
V
T
T
K
L
W
V
S
D
V
G
Y
E
S
T
K
K
A
F
E
K
S
L
K
K
L
Q
L
E
Y
I
D
L
Y
L
I
H
Q
-
P
---------------
F
------------------
G
------------------
D
--------------------
V
------------------
H
C
----------------------------
A
W
K
A
M
E
E
M
Y
K
D
G
L
V
R
A
I
G
V
S
N
F
Y
P
D
R
L
M
D
L
M
V
H
--
H
--
E
I
--
V
--
P
A
V
N
Q
I
E
I
H
P
F
Y
Q
R
Q
E
E
I
E
F
M
R
N
Y
N
I
Q
P
E
A
W
G
P
F
----------
A
E
---
G
--
R
KN---------
I
-------
F
----------
Q
--------
N
G
V
L
R
S
I
A
E
K
Y
G
K
T
V
A
Q
V
I
L
R
W
L
T
Q
K
----
G
I
V
A
I
P
K
T
V
R
R
E
R
M
K
E
N
I
S
I
F
D
F
E
L
T
---
Q
E
D
M
E
K
I
A
T
L
D
-
E
--------------
48
PsiBlast_CBE
83.47
40%
-80
- C7 -
1VP5
1
?
A:
[19-276]
----
T
L
-
N
-
N
G
V
E
---
M
P
I
L
G
Y
G
V
F
---
Q
I
PP
E
K
--
T
E
E
C
---
V
Y
E
A
I
K
V
G
Y
R
L
I
D
T
A
A
S
Y
M
N
E
E
G
V
G
R
A
I
K
R
A
I
-
D
E
--
G
I
V
R
R
E
E
L
F
V
T
T
K
L
W
V
S
D
V
G
Y
E
S
T
K
K
A
F
E
K
S
L
K
K
L
Q
L
E
Y
I
D
L
Y
L
I
H
Q
-
P
---------------
F
------------------
G
------------------
D
--------------------
V
------------------
H
C
----------------------------
A
W
K
A
M
E
E
M
Y
K
D
G
L
V
R
A
I
G
V
S
N
F
Y
P
D
R
L
M
D
L
M
V
H
--
H
--
E
I
--
V
--
P
A
V
N
Q
I
E
I
H
P
F
Y
Q
R
Q
E
E
I
E
F
M
R
N
Y
N
I
Q
P
E
A
W
G
P
F
----------
A
E
---
G
--
R
KN---------
I
-------
F
----------
Q
--------
N
G
V
L
R
S
I
A
E
K
Y
G
K
T
V
A
Q
V
I
L
R
W
L
T
Q
K
----
G
I
V
A
I
P
K
T
V
R
R
E
R
M
K
E
N
I
S
I
F
D
F
E
L
T
---
Q
E
D
M
E
K
I
A
T
L
D
-
E
--------------
61
PsiBlast_CBE
83.41
40%
-86
- C7 -
1FRB
2
ALD2_MOUSE
A:
[12-303]
----------------
M
P
I
V
G
L
G
T
W
---
K
S
--
P
P
--
N
Q
-
V
K
E
A
V
K
A
A
I
D
A
G
Y
R
H
I
D
C
A
Y
A
Y
C
N
E
N
E
V
G
E
A
I
Q
E
K
I
-
K
E
--
K
A
V
Q
R
E
D
L
F
I
V
S
K
L
W
P
T
C
F
E
K
K
L
L
K
E
A
F
Q
K
T
L
T
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
-
P
---------------
Q
GLQPGKEL
F
P
K
D
DQG
R
I
L
T
------------------
S
--------------------
K
------------------
T
T
------
F
L
-------------
E
------
A
W
E
G
M
E
E
L
V
D
Q
G
L
V
K
A
L
G
V
S
N
F
N
H
F
Q
I
E
R
L
L
N
K
--
P
--
G
L
KH
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
S
V
T
A
Y
S
P
L
GSPDRPSAKP
E
D
---
P
--
S
-----------
L
-------
L
----------
E
--------
D
P
K
I
K
E
I
A
A
K
H
E
K
T
S
A
Q
V
L
I
R
F
H
I
Q
R
----
N
V
V
V
I
P
K
S
V
T
P
S
R
I
Q
E
N
I
Q
V
F
D
F
Q
L
S
---
D
E
E
M
A
T
I
L
S
F
N
-
R
N
W
R
A
C
L
L
-
P
E
T
---
70
PsiBlast_CBE
83.38
37%
-81
- C7 -
3UZW
2
AK1D1_HUMAN
A:
[34-328]
---------
D
G
N
S
---
I
P
I
I
G
L
G
T
Y
SEP
K
S
--
T
P
--
K
G
A
C
A
T
S
V
K
V
A
I
D
T
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
-
A
E
--
G
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
-
P
---------------
M
------------------
A
FKPGDEI
Y
P
R
D
ENGKWLY
H
--------------------
K
------------------
S
N
------
L
C
-------------
A
------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
--
P
--
G
L
--
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
L
----------
G
T
---
S
--
R
NPIWVNVSSPP
L
-------
L
----------
K
--------
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
----
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
---
E
E
E
M
K
D
I
E
A
L
N
-
K
N
V
R
F
----------
67
PsiBlast_CBE
82.93
37%
-81
- C7 -
3UZX
5
AK1D1_HUMAN
B:
[34-328]
---------
D
G
N
S
---
I
P
I
I
G
L
G
T
Y
SEP
K
S
--
T
P
--
K
G
A
C
A
T
S
V
K
V
A
I
D
T
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
-
A
E
--
G
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
-
P
---------------
M
------------------
A
FKPGDEIYPRDENGKWLY
H
--------------------
K
------------------
S
N
------
L
C
-------------
A
------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
--
P
--
G
L
--
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
L
----------
G
T
---
S
--
R
NPIWVNVSSPP
L
-------
L
----------
K
--------
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
----
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
---
E
E
E
M
K
D
I
E
A
L
N
-
K
N
V
R
F
----------
66
PsiBlast_CBE
82.82
37%
-82
- C7 -
3UZY
3
AK1D1_HUMAN
A:
[34-328]
---------
D
G
N
S
---
I
P
I
I
G
L
G
T
Y
SEP
K
S
--
T
P
--
K
G
A
C
A
T
S
V
K
V
A
I
D
T
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
-
A
E
--
G
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
-
P
---------------
M
------------------
A
F
KPGDEI
Y
P
R
D
ENG
K
W
L
Y
H
--------------------
K
------------------
S
N
------
L
C
-------------
A
------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
--
P
--
G
L
--
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
L
----------
G
T
---
S
--
R
NPIWVNVSSPP
L
-------
L
----------
K
--------
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
----
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
---
E
E
E
M
K
D
I
E
A
L
N
-
K
N
V
R
F
----------
123
HHSearch
82.76
41%
-78
* C7 *
1VP5
1
?
A:
[21-280]
-------
N
-
N
G
V
E
---
M
P
I
L
G
Y
G
V
F
---
Q
I
--
P
---
P
E
K
T
E
E
C
V
Y
E
A
I
K
V
G
Y
R
L
I
D
T
A
A
S
Y
M
N
E
E
G
V
G
R
A
I
K
R
A
I
-
D
E
--
G
I
V
R
R
E
E
L
F
V
T
T
K
L
W
V
S
D
V
G
Y
E
S
T
K
K
A
F
E
K
S
L
K
K
L
Q
L
E
Y
I
D
L
Y
L
I
H
Q
-
P
---------------
F
------------------
G
------------------
D
-----------------------------------------------
V
H
-------------
C
------
A
W
K
A
M
E
E
M
Y
K
D
G
L
V
R
A
I
G
V
S
N
F
Y
P
D
R
L
M
D
L
M
V
H
--
H
--
E
I
--
V
--
P
A
V
N
Q
I
E
I
H
P
F
Y
Q
R
Q
E
E
I
E
F
M
R
N
Y
N
I
Q
P
E
A
W
G
P
F
----------
A
E
---
G
--
R
-----------
K
-------
N
IF--------
Q
--------
N
G
V
L
R
S
I
A
E
K
Y
G
K
T
V
A
Q
V
I
L
R
W
L
T
Q
K
----
G
I
V
A
I
P
K
T
V
R
R
E
R
M
K
E
N
I
S
I
F
D
F
E
L
T
---
Q
E
D
M
E
K
I
A
T
L
D
-
E
G
Q
S
A
----------
30
PsiBlast_CBE
82.75
43%
-84
- C7 -
3O0K
3
?
D:
[33-283]
---------
D
G
N
H
---
I
P
Q
L
G
Y
G
V
W
---
Q
I
--
S
N
--
D
E
-
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
-------
S
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
-
P
---------------
M
------------------
P
------------------
S
--------------------
K
------------------
D
L
------
F
M
-------------
E
------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
--
S
--
G
V
--
T
--
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
----------
G
-------
K
-----------
L
-------
L
----------
E
--------
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
----
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
GTD
H
D
A
I
T
K
L
D
-------------------
132
HHSearch
82.74
36%
-80
- C7 -
3KRB
4
?
A:
[21-320]
---------
S
M
Q
Y
---
P
P
R
L
G
F
G
T
W
---
Q
A
--
P
---
P
E
A
V
Q
T
A
V
E
T
A
L
M
T
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
E
A
I
G
R
A
F
G
K
I
F
-
K
D
AS
S
G
I
K
R
E
D
V
W
I
T
S
K
L
W
N
Y
N
H
R
P
E
L
V
R
E
Q
C
K
K
T
M
S
D
L
Q
V
D
Y
L
D
L
F
L
V
H
W
-
P
---------------
L
------------------
A
------------------
F
V
RNDVGDL
F
P
K
D
AEG
R
A
M
L
E
K
------------------
V
P
------
L
A
-------------
D
------
T
W
R
A
M
E
Q
L
V
E
E
G
L
V
K
H
I
G
V
S
N
Y
T
V
P
L
L
A
D
L
L
N
Y
--
A
--
K
I
--
K
--
P
L
V
N
Q
I
E
I
H
P
W
H
P
N
D
A
T
V
K
F
C
L
D
N
G
I
G
V
T
A
Y
S
P
M
----------
G
G
---
S
--
Y
-----------
A
-------------------TQKNVILE
C
K
T
L
K
A
I
A
D
A
K
G
T
S
P
H
C
V
A
L
A
W
H
V
K
K
W
NTS
M
Y
S
V
I
P
K
S
Q
T
P
A
R
I
E
A
N
F
K
C
T
E
V
Q
L
S
---
D
D
D
M
D
A
I
N
N
I
H
-
L
N
K
R
I
R
---------
65
PsiBlast_CBE
82.73
37%
-81
- C7 -
3UZY
3
AK1D1_HUMAN
B:
[34-328]
---------
D
G
N
S
---
I
P
I
I
G
L
G
T
Y
SEP
K
S
--
T
P
--
K
G
A
C
A
T
S
V
K
V
A
I
D
T
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
-
A
E
--
G
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
-
P
---------------
M
------------------
A
FKPGDEIYPRDENGKWLY
H
--------------------
K
------------------
S
N
------
L
C
-------------
A
------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
--
P
--
G
L
--
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
L
----------
G
T
---
S
--
R
NPIWVNVSSPP
L
-------
L
----------
K
--------
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
----
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
---
E
E
E
M
K
D
I
E
A
L
N
-
K
N
V
R
F
----------
58
PsiBlast_CBE
82.50
41%
-79
- C7 -
1A80
1
DKGA_CORSC
A:
[9-261]
---------
D
G
N
S
---
I
P
Q
L
G
Y
G
V
F
---
K
V
--
P
P
---
A
D
T
Q
R
A
V
E
E
A
L
E
V
G
Y
R
H
I
D
T
A
A
I
Y
G
N
E
E
----
G
V
G
A
A
I
-
A
A
--
S
G
I
A
R
D
D
L
F
I
T
T
K
L
W
N
D
R
H
D
G
D
E
P
A
A
A
I
A
E
S
L
A
K
L
A
L
D
Q
V
D
L
Y
L
V
H
W
-
P
---------------
T
------------------
P
------------------
A
--------------------
A
------------------
D
N
------
Y
V
-------------
H
------
A
W
E
K
M
I
E
L
R
A
A
G
L
T
R
S
I
G
V
S
N
H
L
V
P
H
L
E
R
I
V
A
A
--
T
--
G
V
--
V
--
P
A
V
N
Q
I
E
L
H
P
A
Y
Q
Q
R
E
I
T
D
W
A
A
A
H
D
V
K
I
E
S
W
G
P
L
----------
G
Q
---
G
--
K
YD---------
L
-------
F
----------
G
--------
A
E
P
V
T
A
A
A
A
A
H
G
K
T
P
A
Q
A
V
L
R
W
H
L
Q
K
----
G
F
V
V
F
P
K
S
V
R
R
E
R
L
E
E
N
L
D
V
F
D
F
D
L
T
---
D
T
E
I
A
A
I
D
A
M
D
----------------
68
PsiBlast_CBE
82.34
37%
-83
- C7 -
3UZX
3
AK1D1_HUMAN
A:
[34-328]
---------
D
G
N
S
---
I
P
I
I
G
L
G
T
Y
SEP
K
S
--
T
P
--
K
G
A
C
A
T
S
V
K
V
A
I
D
T
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
-
A
E
--
G
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
-
P
---------------
M
------------------
A
F
KPGDEI
Y
P
R
D
ENGKWLY
H
--------------------
K
------------------
S
N
------
L
C
-------------
A
------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
--
P
--
G
L
--
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
L
----------
G
T
---
S
--
R
NPIWVNVSSPP
L
-------
L
----------
K
--------
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
----
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
---
E
E
E
M
K
D
I
E
A
L
N
-
K
N
V
R
F
----------
64
PsiBlast_CBE
81.95
37%
-81
- C7 -
3UZZ
3
AK1D1_HUMAN
A:
[34-328]
---------
D
G
N
S
---
I
P
I
I
G
L
G
T
Y
SEP
K
S
--
T
P
--
K
G
A
C
A
T
S
V
K
V
A
I
D
T
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
-
A
E
--
G
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
-
P
---------------
M
------------------
A
F
KPGDEI
Y
P
R
D
ENGKWLY
H
--------------------
K
------------------
S
N
------
L
C
-------------
A
------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
--
P
--
G
L
--
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
L
----------
G
T
---
S
--
R
NPIWVNVSSPP
L
-------
L
----------
K
--------
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
----
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
---
E
E
E
M
K
D
I
E
A
L
N
-
K
N
V
R
F
----------
98
PsiBlast_CBE
81.52
39%
-79
- C7 -
1M9H
2
DKGA_CORSC
A:
[10-262]
---------
D
G
N
S
---
I
P
Q
L
G
Y
G
V
Y
---
K
V
--
P
P
---
A
D
T
Q
R
A
V
E
E
A
L
E
V
G
Y
R
H
I
D
T
A
A
I
Y
G
N
E
E
----
G
V
G
A
A
I
-
A
A
--
S
G
I
A
R
D
D
L
F
I
T
T
K
L
W
N
D
R
H
D
G
D
E
P
A
A
A
I
A
E
S
L
A
K
L
A
L
D
Q
V
D
L
Y
L
V
H
W
-
P
---------------
T
------------------
P
------------------
A
--------------------
A
------------------
D
N
------
Y
V
-------------
H
------
A
W
E
K
M
I
E
L
R
A
A
G
L
T
R
S
I
G
V
S
N
H
L
V
P
H
L
E
R
I
V
A
A
--
T
--
G
V
--
V
--
P
A
V
N
Q
I
E
L
H
P
A
Y
Q
Q
R
E
I
T
D
W
A
A
A
H
D
V
K
I
E
S
W
G
P
L
----------
G
Q
---
G
--
K
YD---------
L
-------
F
----------
G
--------
A
E
P
V
T
A
A
A
A
A
H
G
K
T
P
A
Q
A
V
L
R
W
H
L
Q
K
----
G
F
V
V
F
P
G
S
V
R
R
E
H
L
E
E
N
L
D
V
F
D
F
D
L
T
---
D
T
E
I
A
A
I
D
A
M
D
----------------
60
PsiBlast_CBE
52.31
41%
19
- C7 -
1EKO
2
ALDR_PIG
A:
[7-297]
----
V
L
-
Y
-
T
G
A
K
---
M
P
I
L
G
L
G
T
W
---
K
S
--
P
P
--
G
K
-
V
T
E
A
V
K
V
A
I
D
L
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
L
G
L
Q
E
K
L
-
Q
G
--
Q
V
V
K
R
E
D
L
F
I
V
S
K
L
W
C
T
D
H
E
K
N
L
V
K
G
A
C
Q
T
T
L
R
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
-
P
---------------
T
GFKPGKDP
F
P
L
D
GDG
N
V
V
P
------------------
D
--------------------
E
------------------
S
D
------
F
V
-------------
E
------
T
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
I
G
V
S
N
F
N
H
L
Q
V
E
K
I
L
N
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--
P
--
G
L
KY
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--
P
A
V
N
Q
I
E
V
H
P
Y
L
T
Q
E
K
L
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Y
C
K
S
K
G
I
V
V
T
A
Y
S
P
L
GSPDRPWAKP
E
D
---
P
--
S
-----------
L
-------
L
----------
E
--------
D
P
R
I
K
A
I
A
A
K
Y
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
----
N
L
I
V
I
P
K
S
V
T
P
E
R
I
A
E
N
F
Q
V
F
D
F
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---
P
E
D
M
N
T
L
L
S
Y
N
-
R
N
W
R
V
----------