@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1675: (2016-03-28 )
MGLSADYAPMEFEHTVNGKTEYAGVDIDLAKKIAKDNNLKLKIVNMSFDSLLGALKTGKIDIIISGMTSTPERKKQVDFSDSYMMTKNIMLVKKDKVNEYKDIKDFNNKKVGAQKGTEQEKIAQTEIENASITSLSRLPDVILALKSGKVEGAVVEKPVAEAYLKQNPKLGISNVKFNEEEKDTVIAVPKDSPKLLSQINKTIKEVKDKGLIDKYMTNAANAMNDDSGFISKYGSFFLKGIKITILISLIGVALGSILGAFVALMKLSKIKIISWIASIYIEILRGTPMLVQVFIVFFGITAALGLDISALVCGTIALVINSSAYIAEIIRAGINAVDKGQMEAARSLGLNYRQTMKSVIMPQAIKNILPALGNEFVTLIKESSIVSTIGVGEIMFNAQVVQGISFDPFTPLLVAAALYFVLTFVLTRIMNMIEGRLNASD
Atome Classification :
(21 SA)
----------------------------------...-......10........20........30........40.....-...50....-....60........70........80......-..90.....-...100.......110.......120......--.130---.........140.......150.......160.......170...-....180--...-.....190........200....---...210-.........220.......230.......240-.........250..-------.....260......---.270---...--....280.......290.......300.......310.......320....--...330.......340.......350.......360.......370.......380......--.390.....-..400.......410...----....420.......----430.......440---------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------MGL-SADYAP
M
E
F
E
HTVNGKTEYAGV
D
I
D
L
A
K
K
IAKDNN
L
K
L
K
I
V
NM-
S
F
D
S
L
L
G
A
L
-KTG
K
I
D
I
I
I
SGMTSTP
E
R
KKQVDFSDS
Y
M
M
T
K
-
N
I
M
L
V
KKDK-VN
E
Y
K
D
I
K
D
FNNKKVGAQKGT
E
Q
E
K
I
A
Q
T
EIE--NA-----SI
T
S
L
S
RL
P
D
V
I
L
ALKSGKVE
G
A
VVE
K
P
V
A
E
A
Y
L
KQNPKLGISN
V
-
K
FNEEE---K
D
T
-
V
I
A
VPK-D
S
P
K
L
L
S
Q
I
N
K
T
I
K
E
V
---
K
DKG---
L
I
D
K
Y
M
T
N
AANAMNDD
S
G
F
I
S
K
Y
G
S
F
F
LKG---
I
K
I
T
I
L
I
S
L
I
G
V
A
L
-------
G
S
I
L
G
A
F
V
A
L
M
K
L
S
---
K
I
K
I
---
I
S
W
--
I
A
S
I
Y
I
E
I
LRGT
P
M
L
V
Q
V
F
I
V
F
F
G
I
T
A
A
LG
L
D
I
S
A
L
V
C
G
T
I
A
L
V
INS
S
A
Y
I
--
A
E
I
I
R
A
G
INAVD
K
G
Q
M
E
A
A
R
S
LG
L
N
Y
R
Q
T
M
K
S
V
I
M
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
V
T
L
I
KESS
I
V
S
T
--IGV
G
E
I
M
F
N
-
A
Q
V
VQGISFDP
F
T
P
L
L
V
A
----
A
A
L
Y
F
V
L
T
F
V
L
T
R
I
----
M
N
M
I
E
GRLNASD----------------
62
Fugue
76.13
15%
-96
- C1 -
4Q0C
-
BVGS_BORPE
A:
[66-578]
S
Q
E
L
T
LVGKA
A
V
P
D
V
EVALDGD
D
W
R
W
L
A
R
K
R
V
L
T
L
G
V
Y
A
P
D
I
P
P
F
D
V
T
Y
----
G
E
R
Y
E
G
L
T
A
D
Y
M
A
I
I
A
H
N
L
G
M
Q
A
K
V
L
R
Y
P
T
R
E
Q
A
L
S
A
L
-
E
S
G
Q
I
D
-
L
I
G
T
V
N
G
T
D
G
R
Q
Q
S
L
R
L
S
V
P
Y
A
A
D
H
-
P
V
I
V
M
P
I
G
A
-
R
H
V
P
A
S
--
N
L
A
G
Q
R
L
A
V
D
I
N
Y
L
P
K
E
T
L
A
R
A
Y
P
--
Q
A
-----
T
L
H
Y
F
P
S
S
E
Q
A
L
A
A
V
A
Y
G
Q
A
D
V
F
I
G
D
A
L
T
T
S
H
L
V
S
Q
S
Y
F
N
D
V
R
V
V
-
A
P
A
H
I
A
---
T
G
G
E
S
F
G
V
R
A
-
D
N
T
R
L
L
R
V
V
N
A
V
L
E
A
I
P
P
S
E
H
R
S
---
L
I
Y
R
W
G
L
G
S
S
I
S
L
D
F
A
H
P
A
Y
S
A
R
E
Q
Q
W
M
A
D
H
P
V
V
K
V
A
V
L
N
L
F
A
P
F
T
L
F
R
TDE
Q
F
G
G
I
S
A
A
V
L
Q
L
L
Q
L
R
TG
L
D
F
E
I
---
I
G
V
DT
V
E
E
L
I
A
K
L
R
S
G
E
A
D
M
A
G
A
L
F
V
N
S
A
R
E
S
F
L
S
F
S
R
P
Y
V
R
N
G
M
V
I
V
T
R
Q
D
P
D
A
P
--
V
D
A
D
H
L
D
G
R
T
V
A
L
V
R
N
S
A
A
I
P
L
-
L
Q
R
R
Y
P
Q
A
K
V
V
T
A
D
N
P
S
E
A
M
L
M
V
A
N
G
Q
A
D
A
V
V
Q
T
Q
I
S
A
S
--
Y
Y
V
N
R
Y
F
A
G
K
L
R
I
A
S
A
L
D
L
P
P
A
E
I
A
L
A
T
TRGQ
T
E
L
M
S
I
L
N
K
A
L
Y
S
I
S
N
D
E
L
A
S
I
I
S
R
W
R
G
S
D
G
D
P
R
T
W
Y
A
Y
R
N
E
I
Y
L
E
24
PsiBlast_CBE
74.77
36%
-52
- C1 -
4H5G
3
?
B:
[19-237]
--------------------------------------
S
P
D
Y
A
P
F
E
F
Q
S
L
V
D
G
K
N
Q
V
V
G
A
D
I
D
M
A
Q
A
I
A
D
E
L
G
V
K
L
E
I
L
S
M
-
S
F
D
N
V
L
T
S
L
-
Q
T
G
K
A
D
L
A
V
A
G
I
S
A
T
D
E
R
K
E
V
F
D
F
S
I
P
Y
Y
E
N
K
-
I
S
F
L
V
H
K
A
D
-
V
E
K
Y
K
D
L
T
S
L
E
S
A
N
I
A
A
Q
K
G
T
V
P
E
S
M
V
K
E
Q
L
P
--
K
A
-----
Q
L
T
S
L
T
N
M
G
E
A
V
N
E
L
Q
A
G
K
I
D
A
V
H
M
D
E
P
V
A
L
S
Y
A
A
K
N
A
G
L
A
V
A
T
V
-
S
L
K
M
K
D
---
G
D
A
N
A
V
A
L
R
K
-
N
S
D
D
L
K
E
V
V
D
K
V
I
Q
K
L
---
K
D
E
G
---
T
Y
Q
S
Y
L
E
K
A
A
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.50
36%
-55
- C1 -
4H5F
17
?
A:
[19-237]
--------------------------------------
S
P
D
Y
A
P
F
E
F
Q
S
L
V
D
G
K
N
Q
V
V
G
A
D
I
D
M
A
Q
A
I
A
D
E
L
G
V
K
L
E
I
L
S
M
-
S
F
D
N
V
L
T
S
L
-
Q
T
G
K
A
D
L
A
V
A
G
I
S
A
T
D
E
R
K
E
V
F
D
F
S
I
P
Y
Y
E
N
K
-
I
S
F
L
V
H
K
A
D
-
V
E
K
Y
K
D
L
T
S
L
E
S
A
N
I
A
A
Q
K
G
T
V
P
E
S
M
V
K
E
Q
L
P
--
K
A
-----
Q
L
T
S
L
T
N
M
G
E
A
V
N
E
L
Q
A
G
K
I
D
A
V
H
M
D
E
P
V
A
L
S
Y
A
A
K
N
A
G
L
A
V
A
T
V
-
S
L
K
M
K
D
---
G
D
A
N
A
V
A
L
R
K
-
N
S
D
D
L
K
E
V
V
D
K
V
I
Q
K
L
---
K
D
E
G
---
T
Y
Q
S
Y
L
E
K
A
A
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
74.36
36%
-47
- C1 -
4H5F
16
?
C:
[19-237]
--------------------------------------
S
P
D
Y
A
P
F
E
F
Q
S
L
V
D
G
K
N
Q
V
V
G
A
D
I
D
M
A
Q
A
I
A
D
E
L
G
V
K
L
E
I
L
S
M
-
S
F
D
N
V
L
T
S
L
-
Q
T
G
K
A
D
L
A
V
A
G
I
S
A
T
D
E
R
K
E
V
F
D
F
S
I
P
Y
Y
E
N
K
-
I
S
F
L
V
H
K
A
D
-
V
E
K
Y
K
D
L
T
S
L
E
S
A
N
I
A
A
Q
K
G
T
V
P
E
S
M
V
K
E
Q
L
P
--
K
A
-----
Q
L
T
S
L
T
N
M
G
E
A
V
N
E
L
Q
A
G
K
I
D
A
V
H
M
D
E
P
V
A
L
S
Y
A
A
K
N
A
G
L
A
V
A
T
V
-
S
L
K
M
K
D
---
G
D
A
N
A
V
A
L
R
K
-
N
S
D
D
L
K
E
V
V
D
K
V
I
Q
K
L
---
K
D
E
G
---
T
Y
Q
S
Y
L
E
K
A
A
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
74.14
40%
-57
- C1 -
4YMX
1
?
A:
[41-252]
----------------------------------
M
G
T
-
S
A
D
F
P
P
F
E
F
H
K
V
E
G
G
K
D
E
I
V
G
F
D
I
D
I
A
N
A
I
A
K
K
L
G
V
K
L
E
I
K
D
M
-
D
F
K
G
L
I
P
A
L
-
Q
A
G
R
V
D
M
V
I
A
G
M
T
P
T
A
E
R
K
K
S
V
D
F
S
D
L
Y
Y
D
S
R
-
Q
V
V
V
V
K
N
D
S
P
I
S
K
F
D
D
L
K
---
V
K
T
I
A
V
Q
I
G
T
T
S
E
E
A
A
K
-
K
I
P
--
N
V
-----
K
L
K
Q
L
N
R
V
S
D
E
F
M
D
L
Q
N
G
R
C
D
A
I
V
V
E
D
T
V
A
K
A
Y
L
K
E
Y
K
D
M
K
I
L
Y
M
D
E
I
N
N
V
E
---
N
G
S
-
A
V
A
V
A
K
-
G
N
K
S
L
L
D
V
V
N
E
V
I
K
E
L
---
K
Q
S
G
---
E
Y
D
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.07
38%
-51
- C1 -
4PSH
1
?
A:
[13-226]
----------------------------------
V
G
L
-
S
A
D
F
P
P
F
E
F
---
V
D
E
N
G
N
I
V
G
F
D
V
D
L
A
K
E
I
A
R
R
L
G
V
E
L
K
I
V
D
M
-
T
F
D
G
L
I
P
S
L
-
L
T
K
K
I
D
V
I
I
S
G
M
T
I
T
E
E
R
K
K
V
V
A
F
S
D
P
Y
F
D
A
G
-
Q
V
I
V
V
R
K
D
S
-
D
F
R
P
K
T
Y
E
D
L
V
G
K
T
V
A
V
Q
I
G
T
T
G
D
-
I
E
V
S
K
Y
D
--
G
I
-----
K
V
V
R
F
D
K
F
T
D
A
F
L
E
L
K
R
G
R
A
D
A
V
V
L
D
S
A
T
A
R
A
F
V
A
K
N
P
D
L
V
I
S
S
G
-
V
L
S
S
E
Q
---
Y
G
---
I
A
V
R
K
-
E
D
T
D
L
L
E
F
I
N
S
V
L
R
E
L
---
K
K
S
P
Y
D
V
L
I
E
K
W
F
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
74.03
40%
-55
- C1 -
4YMX
1
?
B:
[41-252]
----------------------------------
M
G
T
-
S
A
D
F
P
P
F
E
F
H
K
V
E
G
G
K
D
E
I
V
G
F
D
I
D
I
A
N
A
I
A
K
K
L
G
V
K
L
E
I
K
D
M
-
D
F
K
G
L
I
P
A
L
-
Q
A
G
R
V
D
M
V
I
A
G
M
T
P
T
A
E
R
K
K
S
V
D
F
S
D
L
Y
Y
D
S
R
-
Q
V
V
V
V
K
N
D
S
P
I
S
K
F
D
D
L
K
---
V
K
T
I
A
V
Q
I
G
T
T
S
E
E
A
A
K
-
K
I
P
--
N
V
-----
K
L
K
Q
L
N
R
V
S
D
E
F
M
D
L
Q
N
G
R
C
D
A
I
V
V
E
D
T
V
A
K
A
Y
L
K
E
Y
K
D
M
K
I
L
Y
M
D
E
I
N
N
V
E
---
N
G
S
-
A
V
A
V
A
K
-
G
N
K
S
L
L
D
V
V
N
E
V
I
K
E
L
---
K
Q
S
G
---
E
Y
D
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
73.54
36%
-51
- C1 -
4H5F
5
?
B:
[19-237]
--------------------------------------
S
P
D
Y
A
P
F
E
F
Q
S
L
V
D
G
K
N
Q
V
V
G
A
D
I
D
M
A
Q
A
I
A
D
E
L
G
V
K
L
E
I
L
S
M
-
S
F
D
N
V
L
T
S
L
-
Q
T
G
K
A
D
L
A
V
A
G
I
S
A
T
D
E
R
K
E
V
F
D
F
S
I
P
Y
Y
E
N
K
-
I
S
F
L
V
H
K
A
D
-
V
E
K
Y
K
D
L
T
S
L
E
S
A
N
I
A
A
Q
K
G
T
V
P
E
S
M
V
K
E
Q
L
P
--
K
A
-----
Q
L
T
S
L
T
N
M
G
E
A
V
N
E
L
Q
A
G
K
I
D
A
V
H
M
D
E
P
V
A
L
S
Y
A
A
K
N
A
G
L
A
V
A
T
V
-
S
L
K
M
K
D
---
G
D
A
N
A
V
A
L
R
K
-
N
S
D
D
L
K
E
V
V
D
K
V
I
Q
K
L
---
K
D
E
G
---
T
Y
Q
S
Y
L
E
K
A
A
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.28
36%
-51
- C1 -
4H5G
10
?
A:
[19-237]
--------------------------------------
S
P
D
Y
A
P
F
E
F
Q
S
L
V
D
G
K
N
Q
V
V
G
A
D
I
D
M
A
Q
A
I
A
D
E
L
G
V
K
L
E
I
L
S
M
-
S
F
D
N
V
L
T
S
L
-
Q
T
G
K
A
D
L
A
V
A
G
I
S
A
T
D
E
R
K
E
V
F
D
F
S
I
P
Y
Y
E
N
K
-
I
S
F
L
V
H
K
A
D
-
V
E
K
Y
K
D
L
T
S
L
E
S
A
N
I
A
A
Q
K
G
T
V
P
E
S
M
V
K
E
Q
L
P
--
K
A
-----
Q
L
T
S
L
T
N
M
G
E
A
V
N
E
L
Q
A
G
K
I
D
A
V
H
M
D
E
P
V
A
L
S
Y
A
A
K
N
A
G
L
A
V
A
T
V
-
S
L
K
M
K
D
---
G
D
A
N
A
V
A
L
R
K
-
N
S
D
D
L
K
E
V
V
D
K
V
I
Q
K
L
---
K
D
E
G
---
T
Y
Q
S
Y
L
E
K
A
A
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
72.95
38%
-51
- C1 -
4PSH
1
?
B:
[13-226]
----------------------------------
V
G
L
-
S
A
D
F
P
P
F
E
F
---
V
D
E
N
G
N
I
V
G
F
D
V
D
L
A
K
E
I
A
R
R
L
G
V
E
L
K
I
V
D
M
-
T
F
D
G
L
I
P
S
L
-
L
T
K
K
I
D
V
I
I
S
G
M
T
I
T
E
E
R
K
K
V
V
A
F
S
D
P
Y
F
D
A
G
-
Q
V
I
V
V
R
K
D
S
-
D
F
R
P
K
T
Y
E
D
L
V
G
K
T
V
A
V
Q
I
G
T
T
G
D
-
I
E
V
S
K
Y
D
--
G
I
-----
K
V
V
R
F
D
K
F
T
D
A
F
L
E
L
K
R
G
R
A
D
A
V
V
L
D
S
A
T
A
R
A
F
V
A
K
N
P
D
L
V
I
S
S
G
-
V
L
S
S
E
Q
---
Y
G
---
I
A
V
R
K
-
E
D
T
D
L
L
E
F
I
N
S
V
L
R
E
L
---
K
K
S
P
Y
D
V
L
I
E
K
W
F
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
72.34
48%
-134
- C2 -
4YMU
2
?
C:
[1-214]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
V
D
F
L
S
M
V
K
Y
T
P
L
F
I
S
G
---
L
I
M
T
L
K
L
T
F
L
A
V
T
I
-------
G
V
L
M
G
L
F
I
A
L
M
K
M
S
---
S
I
K
P
---
I
K
L
--
V
A
S
S
Y
I
E
V
I
R
G
T
P
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
-
F
G
M
N
I
P
A
F
T
A
G
V
S
A
L
A
I
N
S
S
A
Y
V
--
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
--
I
G
F
A
D
L
T
R
Q
-
A
D
I
I
Q
S
V
T
Y
R
Y
F
E
P
Y
I
I
I
----
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
----
L
S
L
F
E
R
R
L
--------------------
14
PsiBlast_PDB
70.92
31%
-58
- C1 -
2Y7I
7
?
A:
[10-214]
----------------------------------
F
G
T
-
S
A
T
Y
A
P
Y
E
F
---
V
D
A
D
N
K
I
V
G
F
D
I
D
V
A
N
A
V
C
K
E
M
Q
A
E
C
S
F
T
N
Q
-
S
F
D
S
L
I
P
S
L
-
R
F
K
K
F
D
A
V
I
A
G
M
D
M
T
P
K
R
E
Q
Q
V
S
F
S
Q
P
Y
Y
E
G
L
-
S
A
V
V
V
T
R
K
G
-
A
--
Y
H
T
F
A
D
L
K
G
K
K
V
G
L
E
N
G
T
T
H
Q
R
Y
L
Q
D
K
Q
Q
--
A
I
-----
T
P
V
A
Y
D
S
Y
L
N
A
F
T
D
L
K
N
N
R
L
E
G
V
F
G
D
V
A
A
I
G
K
W
L
K
N
N
P
D
Y
A
I
M
D
E
-
R
A
S
D
P
D
YYG
K
G
L
-
G
I
A
V
R
K
-
D
N
D
A
L
L
Q
E
I
N
A
A
L
D
K
V
---
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
70.90
31%
-57
- C1 -
2Y7I
6
?
B:
[10-214]
----------------------------------
F
G
T
-
S
A
T
Y
A
P
Y
E
F
---
V
D
A
D
N
K
I
V
G
F
D
I
D
V
A
N
A
V
C
K
E
M
Q
A
E
C
S
F
T
N
Q
-
S
F
D
S
L
I
P
S
L
-
R
F
K
K
F
D
A
V
I
A
G
M
D
M
T
P
K
R
E
Q
Q
V
S
F
S
Q
P
Y
Y
E
G
L
-
S
A
V
V
V
T
R
K
G
-
A
--
Y
H
T
F
A
D
L
K
G
K
K
V
G
L
E
N
G
T
T
H
Q
R
Y
L
Q
D
K
Q
Q
--
A
I
-----
T
P
V
A
Y
D
S
Y
L
N
A
F
T
D
L
K
N
N
R
L
E
G
V
F
G
D
V
A
A
I
G
K
W
L
K
N
N
P
D
Y
A
I
M
D
E
-
R
A
S
D
P
D
YYG
K
G
L
-
G
I
A
V
R
K
-
D
N
D
A
L
L
Q
E
I
N
A
A
L
D
K
V
---
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
70.61
49%
-137
- C2 -
4YMT
2
?
B:
[10-215]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
P
L
F
I
S
G
---
L
I
M
T
L
K
L
T
F
L
A
V
T
I
-------
G
V
L
M
G
L
F
I
A
L
M
K
M
S
---
S
I
K
P
---
I
K
L
--
V
A
S
S
Y
I
E
V
I
R
G
T
P
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
-
F
G
M
N
I
P
A
F
T
A
G
V
S
A
L
A
I
N
S
S
A
Y
V
--
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
--
I
G
F
A
D
L
T
R
Q
-
A
D
I
I
Q
S
V
T
Y
R
Y
F
E
P
Y
I
I
I
----
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
----
L
S
L
F
E
R
R
L
R
-------------------
22
PsiBlast_CBE
70.44
49%
-138
- C2 -
4YMU
2
?
C:
[10-214]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
P
L
F
I
S
G
---
L
I
M
T
L
K
L
T
F
L
A
V
T
I
-------
G
V
L
M
G
L
F
I
A
L
M
K
M
S
---
S
I
K
P
---
I
K
L
--
V
A
S
S
Y
I
E
V
I
R
G
T
P
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
-
F
G
M
N
I
P
A
F
T
A
G
V
S
A
L
A
I
N
S
S
A
Y
V
--
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
--
I
G
F
A
D
L
T
R
Q
-
A
D
I
I
Q
S
V
T
Y
R
Y
F
E
P
Y
I
I
I
----
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
----
L
S
L
F
E
R
R
L
--------------------
5
PsiBlast_PDB
70.37
49%
-139
- C2 -
4YMW
2
?
D:
[10-215]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
P
L
F
I
S
G
---
L
I
M
T
L
K
L
T
F
L
A
V
T
I
-------
G
V
L
M
G
L
F
I
A
L
M
K
M
S
---
S
I
K
P
---
I
K
L
--
V
A
S
S
Y
I
E
V
I
R
G
T
P
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
-
F
G
M
N
I
P
A
F
T
A
G
V
S
A
L
A
I
N
S
S
A
Y
V
--
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
--
I
G
F
A
D
L
T
R
Q
-
A
D
I
I
Q
S
V
T
Y
R
Y
F
E
P
Y
I
I
I
----
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
----
L
S
L
F
E
R
R
L
R
-------------------
2
PsiBlast_PDB
70.37
49%
-139
- C2 -
4YMT
2
?
C:
[10-215]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
P
L
F
I
S
G
---
L
I
M
T
L
K
L
T
F
L
A
V
T
I
-------
G
V
L
M
G
L
F
I
A
L
M
K
M
S
---
S
I
K
P
---
I
K
L
--
V
A
S
S
Y
I
E
V
I
R
G
T
P
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
-
F
G
M
N
I
P
A
F
T
A
G
V
S
A
L
A
I
N
S
S
A
Y
V
--
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
--
I
G
F
A
D
L
T
R
Q
-
A
D
I
I
Q
S
V
T
Y
R
Y
F
E
P
Y
I
I
I
----
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
----
L
S
L
F
E
R
R
L
R
-------------------
4
PsiBlast_PDB
69.75
49%
-135
- C2 -
4YMV
-
?
D:
[10-215]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
P
L
F
I
S
G
---
L
I
M
T
L
K
L
T
F
L
A
V
T
I
-------
G
V
L
M
G
L
F
I
A
L
M
K
M
S
---
S
I
K
P
---
I
K
L
--
V
A
S
S
Y
I
E
V
I
R
G
T
P
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
-
F
G
M
N
I
P
A
F
T
A
G
V
S
A
L
A
I
N
S
S
A
Y
V
--
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
--
I
G
F
A
D
L
T
R
Q
-
A
D
I
I
Q
S
V
T
Y
R
Y
F
E
P
Y
I
I
I
----
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
----
L
S
L
F
E
R
R
L
R
-------------------
10
PsiBlast_PDB
69.65
38%
-57
- C1 -
4PRS
-
?
A:
[13-226]
----------------------------------
V
G
L
-
S
A
D
F
P
P
F
E
F
---
V
D
E
N
G
N
I
V
G
F
D
V
D
L
A
K
E
I
A
R
R
L
G
V
E
L
K
I
V
D
M
-
T
F
D
G
L
I
P
S
L
-
L
T
K
K
I
D
V
I
I
S
G
M
T
I
T
E
E
R
K
K
V
V
A
F
S
D
P
Y
F
D
A
G
-
Q
V
I
V
V
R
K
D
S
-
D
F
R
P
K
T
Y
E
D
L
V
G
K
T
V
A
V
Q
I
G
T
T
G
D
-
I
E
V
S
K
Y
D
--
G
I
-----
K
V
V
R
F
D
K
F
T
D
A
F
L
E
L
K
R
G
R
A
D
A
V
V
L
D
S
A
T
A
R
A
F
V
A
K
N
P
D
L
V
I
S
S
G
-
V
L
S
S
E
Q
---
Y
G
---
I
A
V
R
K
-
E
D
T
D
L
L
E
F
I
N
S
V
L
R
E
L
---
K
K
S
P
Y
D
V
L
I
E
K
W
F
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
69.62
16%
-74
- C1 -
4P0G
9
MLTF_PSEAE
A:
[7-435]
---------------------APT
A
L
E
R
V
Q
K
E
G
V
L
R
V
-
I
T
R
N
S
P
A
T
Y
F
Q
D
R
N
G
E
T
---
G
F
E
Y
E
L
A
K
R
F
A
E
R
L
G
V
E
L
K
I
E
T
A
D
N
L
D
D
L
Y
A
Q
L
S
R
E
G
G
P
A
L
A
A
A
G
L
T
P
G
R
E
D
D
A
S
V
R
Y
S
H
T
Y
L
D
V
--
T
P
Q
I
I
Y
R
N
G
-
Q
Q
R
P
T
R
P
E
D
L
V
G
K
R
I
M
V
L
K
G
S
S
H
A
E
Q
L
A
E
L
K
K
--
Q
Y
PE
L
K
Y
E
E
S
D
A
V
E
V
V
D
L
L
R
M
V
D
V
G
D
I
D
L
T
L
V
D
S
N
E
L
A
M
N
Q
V
Y
F
P
N
--
V
R
V
A
-
F
D
F
G
E
A
---
R
G
L
-
A
W
A
L
P
G
G
D
D
D
S
L
M
N
E
V
N
A
F
L
D
Q
A
---
K
K
E
G
---
L
L
Q
R
L
K
D
R
Y
Y
-------
G
H
V
D
V
L
G
------------
Y
V
G
A
Y
T
F
A
Q
H
L
-------
Q
Q
R
L
P
R
Y
E
S
H
F
K
Q
S
---
G
K
Q
L
DTD
W
R
L
--
L
A
A
I
G
Y
Q
E
S
L
W
Q
P
----------
G
A
T
S
K
T
G
V
R
G
L
M
M
L
T
N
R
T
A
Q
A
M
G
V
S
N
R
L
D
P
K
Q
S
I
Q
G
G
S
K
Y
F
V
Q
I
R
S
E
L
P
E
S
I
----
K
E
P
D
R
S
W
F
A
L
A
A
Y
-
N
I
G
G
A
H
L
E
D
A
R
K
M
A
E
K
E
G
L
N
P
N
K
W
L
D
V
K
K
M
L
P
R
-
L
A
Q
K
Q
W
Y
A
K
T
R
Y
G
Y
A
R
G
G
----
E
T
V
H
F
V
Q
N
--
V
R
R
Y
----
Y
D
I
L
T
W
V
T
Q
P
Q
-----------------
30
PsiBlast_CBE
66.21
32%
-43
- C1 -
4KPT
10
?
B:
[36-242]
---------------------------------------
S
S
Y
A
P
F
E
F
Q
---
N
G
Q
K
K
W
V
G
I
D
V
D
I
M
Q
E
V
A
K
I
N
D
W
K
L
E
M
S
Y
P
-
G
F
D
A
A
L
Q
N
L
-
K
A
G
Q
V
D
G
I
I
A
G
M
T
I
T
D
E
R
K
E
T
F
D
F
S
N
P
Y
Y
T
S
A
L
T
I
A
T
T
K
D
S
K
-
L
S
D
Y
S
D
L
K
---
G
K
A
V
G
A
K
N
G
T
A
A
Q
T
W
L
Q
E
N
Q
K
KY
G
Y
-----
T
I
K
T
Y
S
D
G
V
H
M
F
A
A
L
S
S
G
N
I
A
G
A
M
D
E
V
P
V
I
S
Y
A
M
K
Q
G
Q
D
L
A
M
N
F
P
-
S
I
S
L
P
G
---
G
Y
G
-
F
A
V
M
K
G
-
K
N
S
T
L
V
D
G
F
N
K
A
L
A
E
M
---
K
S
N
G
---
D
Y
D
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------