@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1681: (2016-03-28 )
MNFSESERLQQLSNEYILGGVNSPSRSYKAVGGGAPVVMKEGHGAYLYDVDGNKFIDYLQAYGPIIAGHAHPHITKAIQEQAAKGVLFGTPTELEIEFSKKLRDAIPSLEKIRFVNSGTEAVMTTIRVARAYTKRNKIIKFAGSYHGHSDLVLVAAGSGPSQLGSPDSAGVPESVAREVITVPFNDINAYKEAIEFWGDEIAAVLVEPIVGNFGMVMPQPGFLEEVNEISHNNGTLVIYDEVITAFRFHYGAAQDLLGVIPDLTAFGKIVGGGLPIGGYGGRQDIMEQVAPLGPAYQAGTMAGNPLSMKAGIALLEVLEQDGVYEKLDSLGQQLEEGLLKLIEKHNITATINRIYGSLTLYFTDEKVTHYDQVEHSDGEAFGKFFKLMLNQGINLAPSKFEAWFLTTEHTEEDIQQTLKAADYAFSQMK
Atome Classification :
(53 SA)
.........10........20........30........40........50........60........70........80.....----...90........100.......110.......120.......130..-----.....140.......150.......160..-.....170.......180.......190.......200.......210.......220.......230.......240....-...250.......260.......270.......280.......290.--.......300.......310.......320........330.......340......---.350-......-.360.......370.......380.......390.......400.......410.......420.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNF
S
E
S
E
R
L
Q
Q
L
SNE
Y
I
LGGVNSPSRSYKAVGGGA
P
V
V
M
KEGH
G
A
Y
L
Y
DVDG
N
K
F
I
D
Y
L
Q
AYGPIIAGHAH
P
H
I
T
K
A
I
Q
E
Q
AAK
G
V
----
L
FGTP
T
E
L
E
I
E
F
S
K
K
L
R
D
AIP
S
L
E
K
I
R
FVNSG
T
E
A
V
M
T
T
I
R
V
A
R
A
Y
TK-----RN
K
I
I
K
F
AGSYHGHS
D
L
V
L
V
AAGS
G
P
SQLG-SPDSAGV
P
E
S
V
A
R
E
V
I
T
VPF
N
D
I
N
A
Y
K
E
A
I
E
F
W
G
D
E
I
A
A
V
L
V
E
P
I
VGNFGMVMPQP
G
F
L
E
E
V
N
E
ISHNN
G
T
L
V
I
Y
D
E
V
I
T
A
F
-
R
FHYG
A
A
Q
D
L
L
G
VIP
D
L
T
A
F
G
K
I
VGGGLPIGGYG
G
R
Q
D
I
M
E
Q
VAP-L--GPAYQAGTMAGNP
L
S
M
K
A
G
I
A
L
L
E
V
L
E
QD-
G
V
Y
E
K
L
D
S
L
G
Q
Q
L
E
E
G
L
L
K
L
I
E
KHN
I
T
---
A
T
I
N
-
R
IYG
S
L
-
T
L
Y
F
TDEKVTH
Y
D
QVEHSD
G
E
A
F
G
K
F
F
K
L
M
L
NQGINLAPSK
F
E
A
W
F
L
TTEH
T
E
E
D
I
Q
Q
T
L
K
A
A
D
Y
A
FSQMK
21
PsiBlast_CBE
92.77
48%
-86
- C1 -
3FQ8
2
GSA_SYNP6
B:
[5-427]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
-
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
2
PsiBlast_PDB
92.70
48%
-87
- C1 -
3FQ8
2
GSA_SYNP6
A:
[5-427]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
-
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
5
PsiBlast_PDB
92.45
47%
-93
- C1 -
2HOZ
3
GSA_SYNP6
A:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
-
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
114
HHSearch
92.10
48%
-85
- C1 -
3FQ8
2
GSA_SYNP6
A:
[2-426]
-
K
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
-
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
-
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
--
3
PsiBlast_PDB
91.64
48%
-88
- C1 -
3FQA
3
GSA_SYNP6
A:
[5-427]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
-
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
8
PsiBlast_PDB
91.36
47%
-87
- C1 -
3FQ7
2
GSA_SYNP6
A:
[5-427]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
-
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
6
PsiBlast_PDB
90.72
47%
-88
- C1 -
2HP1
3
GSA_SYNP6
A:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
-
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
28
PsiBlast_CBE
90.60
47%
-86
- C1 -
3FQ7
2
GSA_SYNP6
B:
[5-427]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
-
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
22
PsiBlast_CBE
90.41
48%
-86
- C1 -
3FQA
3
GSA_SYNP6
B:
[5-427]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
-
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
10
PsiBlast_PDB
90.21
47%
-84
- C1 -
2GSA
2
GSA_SYNP6
A:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
-
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
103
Fugue
90.06
47%
-83
- C1 -
2GSA
2
GSA_SYNP6
A:
[6-432]
F
K
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
-
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
25
PsiBlast_CBE
90.02
47%
-92
- C1 -
2HOZ
2
GSA_SYNP6
B:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
--------
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
29
PsiBlast_CBE
90.01
47%
-86
* C1 *
4GSA
2
GSA_SYNP6
B:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
-
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
7
PsiBlast_PDB
89.67
47%
-89
- C1 -
2HP2
3
GSA_SYNP6
A:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
-
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
9
PsiBlast_PDB
89.63
47%
-86
- C1 -
3USF
3
GSA_SYNE7
A:
[5-427]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
-
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
11
PsiBlast_PDB
89.40
47%
-85
- C1 -
4GSA
2
GSA_SYNP6
A:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
-
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
30
PsiBlast_CBE
89.39
47%
-86
- C1 -
3GSB
3
GSA_SYNP6
B:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
-
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
1
PsiBlast_PDB
89.33
47%
-90
- C1 -
3BS8
1
GSA_BACSU
A:
[19-435]
--
F
K
E
A
Q
K
L
-------
M
P
G
G
V
N
S
P
V
R
A
F
K
S
V
D
M
D
-
P
I
F
M
E
R
G
K
G
S
K
I
F
D
I
D
G
N
E
Y
I
D
Y
V
L
S
W
G
P
L
I
L
G
H
T
N
D
R
V
V
E
S
L
K
K
V
A
E
Y
G
T
----
S
F
G
A
P
T
E
V
E
N
E
L
A
K
L
V
I
D
R
V
P
S
V
E
I
V
R
M
V
S
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
-----
R
N
K
I
L
K
F
E
G
C
Y
H
G
H
G
D
S
L
L
I
K
A
G
S
G
V
A
T
L
G
-
L
P
D
S
P
G
V
P
E
G
I
A
K
N
T
I
T
V
P
Y
N
D
L
E
S
V
K
L
A
F
Q
Q
F
G
E
D
I
A
G
V
I
V
E
P
V
A
G
N
M
G
V
V
P
P
Q
E
G
F
L
Q
G
L
R
D
I
T
E
Q
Y
G
S
L
L
I
F
D
E
V
M
T
G
F
-
R
V
D
Y
N
C
A
Q
G
Y
F
G
V
T
P
D
L
T
C
L
G
K
V
I
G
G
G
L
P
V
G
A
Y
G
G
K
A
E
I
M
E
Q
I
A
P
-
S
--
G
P
I
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
L
E
T
L
K
Q
L
T
P
D
-
S
-
Y
K
N
F
I
K
K
G
D
R
L
E
E
G
I
S
K
A
A
E
A
H
G
I
P
---
H
T
F
N
-
R
A
G
S
M
I
-
G
F
F
F
T
N
E
P
V
I
N
Y
E
T
A
K
A
S
D
L
K
L
F
A
S
Y
Y
K
G
M
A
N
E
G
V
F
L
P
P
S
Q
F
E
G
L
F
L
S
T
A
H
T
D
E
D
I
E
N
T
I
Q
A
A
E
K
V
F
A
E
I
-
31
PsiBlast_CBE
89.14
47%
-87
- C1 -
2GSA
2
GSA_SYNP6
B:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
-
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
23
PsiBlast_CBE
88.65
47%
-83
- C1 -
2HP2
3
GSA_SYNP6
B:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
-
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
12
PsiBlast_PDB
88.48
47%
-88
- C1 -
3GSB
3
GSA_SYNP6
A:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
-
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
14
PsiBlast_PDB
88.40
46%
-87
- C1 -
2E7U
4
GSA_THET8
A:
[6-424]
-----
S
E
A
Y
F
Q
E
A
K
R
H
I
P
G
G
V
S
S
P
V
R
A
F
K
A
V
G
G
T
P
P
F
L
V
R
-
G
E
G
A
Y
V
W
D
A
D
G
N
R
Y
L
D
Y
V
M
S
W
G
P
L
I
L
G
H
A
H
P
K
V
L
A
R
V
R
E
T
L
E
R
G
L
----
T
F
G
A
P
S
P
L
E
V
A
L
A
K
K
V
K
R
A
Y
P
F
V
D
L
V
R
F
V
N
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
-----
R
P
Y
I
V
K
F
R
G
N
Y
H
G
H
A
D
G
L
L
V
E
A
G
S
G
A
L
T
L
G
-
V
P
S
S
A
G
V
P
E
E
Y
A
K
L
T
L
V
L
E
Y
N
D
P
E
G
L
R
E
V
L
K
R
R
G
E
E
I
A
A
I
I
F
E
P
V
V
G
N
A
G
V
L
V
P
T
E
D
F
L
K
A
L
H
E
-
A
K
A
Y
G
V
L
L
I
A
D
E
V
M
T
G
F
-
R
L
A
F
G
G
A
T
E
L
L
G
L
K
P
D
L
V
T
L
G
K
I
L
G
G
G
L
P
A
A
A
Y
A
G
R
R
E
I
M
E
K
V
A
P
-
L
--
G
P
V
Y
Q
A
G
T
L
S
G
N
P
L
A
M
A
A
G
L
A
T
L
E
L
L
E
E
N
P
G
Y
Y
A
Y
L
E
D
L
G
A
R
L
E
A
G
L
K
E
V
L
K
E
K
G
L
P
---
H
T
V
N
-
R
V
G
S
M
I
-
T
V
F
F
T
E
G
P
V
V
T
F
Q
D
A
R
R
T
D
T
E
L
F
K
R
F
F
H
G
L
L
D
R
G
I
Y
W
P
P
S
N
F
E
A
A
F
L
S
V
A
H
R
E
E
D
V
E
K
T
L
E
A
L
R
K
A
L
----
113
HHSearch
87.95
47%
-84
- C1 -
2E7U
4
GSA_THET8
A:
[1-424]
M
E
R
P
I
S
E
A
Y
F
Q
E
A
K
R
H
I
P
G
G
V
S
S
P
V
R
A
F
K
A
-
V
G
G
T
P
P
F
L
V
R
G
E
G
A
Y
V
W
D
A
D
G
N
R
Y
L
D
Y
V
M
S
W
G
P
L
I
L
G
H
A
H
P
K
V
L
A
R
V
R
E
T
L
E
R
G
L
----
T
F
G
A
P
S
P
L
E
V
A
L
A
K
K
V
K
R
A
Y
P
F
V
D
L
V
R
F
V
N
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
-----
R
P
Y
I
V
K
F
R
G
N
Y
H
G
H
A
D
G
L
L
V
E
A
G
S
G
A
L
T
L
G
-
V
P
S
S
A
G
V
P
E
E
Y
A
K
L
T
L
V
L
E
Y
N
D
P
E
G
L
R
E
V
L
K
R
R
G
E
E
I
A
A
I
I
F
E
P
V
V
G
N
A
G
V
L
V
P
T
E
D
F
L
K
A
L
H
E
-
A
K
A
Y
G
V
L
L
I
A
D
E
V
M
T
G
F
-
R
L
A
F
G
G
A
T
E
L
L
G
L
K
P
D
L
V
T
L
G
K
I
L
G
G
G
L
P
A
A
A
Y
A
G
R
R
E
I
M
E
K
V
A
P
-
L
--
G
P
V
Y
Q
A
G
T
L
S
G
N
P
L
A
M
A
A
G
L
A
T
L
E
L
L
E
E
N
P
G
Y
Y
A
Y
L
E
D
L
G
A
R
L
E
A
G
L
K
E
V
L
K
E
K
G
L
P
---
H
T
V
N
-
R
V
G
S
M
I
-
T
V
F
F
T
E
G
P
V
V
T
F
Q
D
A
R
R
T
D
T
E
L
F
K
R
F
F
H
G
L
L
D
R
G
I
Y
W
P
P
S
N
F
E
A
A
F
L
S
V
A
H
R
E
E
D
V
E
K
T
L
E
A
L
R
K
A
L
----
27
PsiBlast_CBE
86.10
47%
-91
- C1 -
3USF
3
GSA_SYNE7
B:
[5-427]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
--------------------------
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
24
PsiBlast_CBE
84.81
47%
-91
- C1 -
2HP1
3
GSA_SYNP6
B:
[10-432]
----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
----
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
-----
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
------------------------------
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
-
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-
13
PsiBlast_PDB
80.83
49%
-98
- C1 -
2CFB
1
GSA_THEEB
A:
[19-411]
-----------------------------------
P
I
V
F
D
H
V
K
G
A
H
I
W
D
V
D
G
N
Q
Y
I
D
Y
V
G
S
W
G
P
A
I
V
G
H
A
H
P
E
V
I
D
A
L
H
A
A
L
E
K
G
T
----
S
F
G
A
P
C
L
L
E
N
I
L
A
E
M
V
I
A
A
V
P
S
V
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
Q
-----
R
E
K
V
I
K
F
E
G
C
Y
H
G
H
A
-----------------------------
A
T
L
T
A
P
Y
N
D
L
E
A
V
S
R
L
F
E
Q
Y
P
N
D
I
A
G
V
I
L
E
P
V
V
G
N
A
G
F
I
P
P
D
A
G
F
L
E
G
L
R
E
L
T
K
Q
Y
G
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
A
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
V
I
G
G
G
L
P
V
G
A
Y
G
G
R
A
E
I
M
K
M
V
A
P
-
A
--
G
P
-----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
I
L
S
R
P
-
G
S
Y
E
H
L
D
R
I
T
G
K
L
V
Q
G
L
L
D
A
A
R
E
F
G
H
E
---
V
C
G
G
-
H
I
S
G
M
F
-
G
L
F
F
T
A
G
P
V
T
N
Y
E
Q
A
K
Q
S
D
L
K
K
F
A
A
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
A
D
I
E
R
T
I
A
A
A
R
T
V
L
S
Q
L
-
33
PsiBlast_CBE
77.87
40%
-86
- C1 -
2ZSM
4
GSA_AERPE
B:
[11-418]
----
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
---
A
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
----
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
-----
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
-
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
E
-
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
---
Y
T
I
N
-
R
V
E
S
M
M
-
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
--------------
17
PsiBlast_PDB
77.17
40%
-84
- C1 -
2ZSM
2
GSA_AERPE
A:
[11-418]
----
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
---
A
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
----
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
-----
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
-
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
E
-
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
---
Y
T
I
N
-
R
V
E
S
M
M
-
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
--------------
32
PsiBlast_CBE
77.11
40%
-84
- C1 -
2ZSM
4
GSA_AERPE
C:
[11-418]
----
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
---
A
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
----
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
-----
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
-
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
E
-
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
---
Y
T
I
N
-
R
V
E
S
M
M
-
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
--------------
16
PsiBlast_PDB
75.98
40%
-82
- C1 -
2ZSL
1
GSA_AERPE
A:
[11-418]
----
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
---
A
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
----
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
-----
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
-
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
E
-
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
---
Y
T
I
N
-
R
V
E
S
M
M
-
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
--------------
15
PsiBlast_PDB
75.97
40%
-83
- C1 -
2EPJ
1
GSA_AERPE
A:
[11-418]
----
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
---
A
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
----
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
-----
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
-
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
E
-
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
---
Y
T
I
N
-
R
V
E
S
M
M
-
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
--------------
121
HHSearch
70.59
37%
-74
- C1 -
2EPJ
1
GSA_AERPE
A:
[9-431]
--
G
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
A
V
---
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
----
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
-----
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
-
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
E
-
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
Y
T
I
N
R
V
E
S
M
M
Q
L
F
I
-
G
V
E
E
V
S
N
A
A
Q
----
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
G
L
R
S
S
L
K
T
V
-
49
PsiBlast_CBE
67.09
31%
-91
- C1 -
4AO9
2
BFAT_VARPD
A:
[70-438]
-----------------------------------
P
L
T
I
A
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
M
Q
G
G
I
----
N
L
T
G
H
N
L
L
E
G
R
L
A
R
L
I
C
E
R
F
P
Q
I
E
Q
L
R
F
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
-----
R
R
K
I
V
V
F
S
G
G
Y
H
G
G
----
V
L
G
F
G
A
R
P
S
-----------
P
T
T
V
P
F
D
F
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
R
-
L
A
P
H
G
L
A
N
K
-
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
L
F
D
P
R
T
--
G
P
L
A
H
S
G
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
L
F
T
P
-
E
A
A
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
---
M
Q
F
T
-
G
I
G
S
L
M
-
N
A
H
F
V
Q
G
D
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
--
V
V
L
S
L
P
L
T
D
A
D
I
D
R
Y
V
A
A
---------
46
PsiBlast_CBE
66.46
31%
-90
- C1 -
4AOA
2
BFAT_VARPD
B:
[70-438]
-----------------------------------
P
L
T
I
A
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
M
Q
G
G
I
----
N
L
T
G
H
N
L
L
E
G
R
L
A
R
L
I
C
E
R
F
P
Q
I
E
Q
L
R
F
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
-----
R
R
K
I
V
V
F
S
G
G
Y
H
G
G
----
V
L
G
F
G
A
R
P
S
-----------
P
T
T
V
P
F
D
F
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
R
-
L
A
P
H
G
L
A
N
K
-
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
L
F
D
P
R
T
--
G
P
L
A
H
S
G
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
L
F
T
P
-
E
A
A
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
---
M
Q
F
T
-
G
I
G
S
L
M
-
N
A
H
F
V
Q
G
D
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
--
V
V
L
S
L
P
L
T
D
A
D
I
D
R
Y
V
A
A
---------
48
PsiBlast_CBE
66.10
31%
-91
- C1 -
4AO9
3
BFAT_VARPD
B:
[70-438]
-----------------------------------
P
L
T
I
A
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
M
Q
G
G
I
----
N
L
T
G
H
N
L
L
E
G
R
L
A
R
L
I
C
E
R
F
P
Q
I
E
Q
L
R
F
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
-----
R
R
K
I
V
V
F
S
G
G
Y
H
G
G
----
V
L
G
F
G
A
R
P
S
-----------
P
T
T
V
P
F
D
F
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
R
-
L
A
P
H
G
L
A
N
K
-
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
L
F
D
P
R
T
--
G
P
L
A
H
S
G
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
L
F
T
P
-
E
A
A
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
---
M
Q
F
T
-
G
I
G
S
L
M
-
N
A
H
F
V
Q
G
D
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
--
V
V
L
S
L
P
L
T
D
A
D
I
D
R
Y
V
A
A
---------
47
PsiBlast_CBE
63.19
31%
-88
- C1 -
4AOA
3
BFAT_VARPD
A:
[70-438]
-----------------------------------
P
L
T
I
A
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
M
Q
G
G
I
----
N
L
T
G
H
N
L
L
E
G
R
L
A
R
L
I
C
E
R
F
P
Q
I
E
Q
L
R
F
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
-----
R
R
K
I
V
V
F
S
G
G
Y
H
G
G
----
V
L
G
F
G
A
R
P
S
-----------
P
T
T
V
P
F
D
F
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
R
-
L
A
P
H
G
L
A
N
K
-
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
L
F
D
P
R
T
--
G
P
L
A
H
S
G
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
L
F
T
P
-
E
A
A
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
---
M
Q
F
T
-
G
I
G
S
L
M
-
N
A
H
F
V
Q
G
D
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
--
V
V
L
S
L
P
L
T
D
A
D
I
D
R
Y
V
A
A
---------
37
PsiBlast_CBE
61.02
32%
-83
- C1 -
2YKY
10
?
C:
[83-447]
-----------------------------------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
----
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
-----
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
-------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
-
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
19
PsiBlast_PDB
60.72
32%
-83
- C1 -
2YKV
10
?
A:
[83-447]
-----------------------------------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
----
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
-----
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
-------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
-
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
38
PsiBlast_CBE
60.68
32%
-82
- C1 -
2YKY
13
?
B:
[83-447]
-----------------------------------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
----
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
-----
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
-------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
-
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
34
PsiBlast_CBE
60.37
32%
-85
- C1 -
4AO4
4
?
C:
[83-447]
-----------------------------------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
----
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
-----
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
-------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
-
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
40
PsiBlast_CBE
60.36
32%
-84
- C1 -
2YKX
6
?
C:
[83-447]
-----------------------------------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
----
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
-----
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
-------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
-
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
36
PsiBlast_CBE
60.16
32%
-85
- C1 -
4AO4
5
?
A:
[83-447]
-----------------------------------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
----
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
-----
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
-------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
-
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
45
PsiBlast_CBE
60.08
32%
-83
- C1 -
2YKU
9
?
B:
[83-447]
-----------------------------------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
----
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
-----
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
-------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
-
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
44
PsiBlast_CBE
60.03
32%
-83
- C1 -
2YKU
6
?
C:
[83-447]
-----------------------------------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
----
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
-----
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
-------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
-
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
43
PsiBlast_CBE
60.01
32%
-83
- C1 -
2YKV
11
?
B:
[83-447]
-----------------------------------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
----
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
-----
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
-------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
-
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
42
PsiBlast_CBE
60.00
32%
-83
- C1 -
2YKV
10
?
C:
[83-447]
-----------------------------------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
----
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
-----
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
-------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
-
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
39
PsiBlast_CBE
60.00
32%
-82
- C1 -
2YKY
11
?
A:
[83-447]
-----------------------------------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
----
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
-----
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
-------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
-
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
41
PsiBlast_CBE
59.43
32%
-84
- C1 -
2YKX
4
?
B:
[83-447]
-----------------------------------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
----
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
-----
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
-------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
-
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
35
PsiBlast_CBE
59.21
32%
-82
- C1 -
4AO4
6
?
B:
[83-447]
-----------------------------------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
----
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
-----
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
-------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
-
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
20
PsiBlast_PDB
59.10
32%
-82
- C1 -
2YKX
8
?
A:
[83-447]
-----------------------------------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
----
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
-----
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
-------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
-
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
18
PsiBlast_PDB
58.99
32%
-82
- C1 -
2YKU
9
?
A:
[83-447]
-----------------------------------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
----
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
-----
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
-------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
-
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
----------------
88
PsiBlast_CBE
36.89
31%
-73
- C1 -
2EH6
2
ARGD_AQUAE
B:
[11-290]
-----------------------------------
P
V
K
F
V
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
H
A
Y
P
K
L
T
E
A
L
K
E
Q
V
E
K
L
L
HVSN
L
Y
E
N
P
W
Q
E
E
L
--
A
H
K
L
V
K
H
F
W
T
E
G
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
Y
W
R
DKGKN
K
W
K
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
Q
P
K
F
H
K
G
F
E
P
L
V
P
G
F
--
S
Y
A
K
------
L
N
D
I
D
S
V
Y
K
L
L
D
---
E
E
T
A
G
I
I
I
E
V
I
Q
G
E
G
G
V
N
E
A
S
E
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
G
G
V
P
I
G
A
I
L
A
R
E
E
V
A
Q
S
F
T
------
P
G
S
H
G
S
T
F
G
G
N
P
L
A
C
R
A
G
T
V
V
V
D
E
V
E
K
-------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
36.10
31%
-73
- C1 -
2EH6
2
ARGD_AQUAE
A:
[11-290]
-----------------------------------
P
V
K
F
V
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
H
A
Y
P
K
L
T
E
A
L
K
E
Q
V
E
K
L
L
HVSN
L
Y
E
N
P
W
Q
E
E
L
--
A
H
K
L
V
K
H
F
W
T
E
G
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
Y
W
R
D
K
GKN
K
W
K
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
Q
P
K
F
H
K
G
F
E
P
L
V
P
G
F
--
S
Y
A
K
------
L
N
D
I
D
S
V
Y
K
L
L
D
---
E
E
T
A
G
I
I
I
E
V
I
Q
G
E
G
G
V
N
E
A
S
E
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
G
G
V
P
I
G
A
I
L
A
R
E
E
V
A
Q
S
F
T
------
P
G
S
H
G
S
T
F
G
G
N
P
L
A
C
R
A
G
T
V
V
V
D
E
V
E
K
-------------------------------------------------------------------------------------------------------------------