@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1683: (2016-03-28 )
MIKRYLQFVKPYKYRIFATIIVGIIKFGIPMLIPLLIKYAIDGVINNHALTTDEKVHHLTIAIGIALFIFVIVRPPIEFIRQYLAQWTSNKILYDIRKKLYNHLQALSARFYANNQVGQVISRVINDVEQTKDFILTGLMNIWLDCITIIIALSIMFFLDVKLTLAALFIFPFYILTVYVFFGRLRKLTRERSQALAEVQGFLHERVQGISVVKSFAIEDNEAKNFDKKNTNFLTRALKHTRWNAYSFAAINTVTDIGPIIVIGVGAYLAISGSITVGTLAAFVGYLELLFGPLRRLVASFTTLTQSFASMDRVFQLIDEDYDIKNGVGAQPIEIKQGRIDIDHVSFQYNDNEAPILKDINLSIEKGETVAFVGMSGGGKSTLINLIPRFYDVTSGQILIDGHNIKDFLTGSLRNQIGLVQQDNILFSDTVKENILLGRPTATDEEVVEAAKMANAHDFIMNLPQGYDTEVGERGVKLSGGQKQRLSIARIFLNNPPILILDEATSALDLESESIIQEALDVLSKDRTTLIVAHRLSTITHADKIVVIENGHIVETGTHRELIAKQGAYEHLYSIQNL
Atome Classification :
(53 SA)
---------------------------------------------------------.........10....-....20........30........40........50----------------........60........70........80.......--.90........100.......110.......120.......130.......140.......150.......160.......170.......180..-.....190.......200.......210.......220.......230.......240.--......250.......260.......270.......280........290.......300.......310----.......--320..---....--...----330....-...340.......-350-.......360.......370.......380.......390..---.....400.......410.......420.......430......-.--440--.-....-...450.......460.......470.......480.......490.......500.......510.-......520.--.--.....530.......540.......550.......560..--.--.-...570......-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------
M
I
K
R
Y
L
Q
F
VKPY
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
VINNHALT----------------TDEK
V
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
IVRP
P
I
E
F
I
R
Q
Y
L
A
Q
WT--SN
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
FYAN
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
-
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
FAIEDNEAKNFDKK
N
T
N
F
L
T
R
A
L
K
HTRW--N
A
Y
S
F
A
A
I
N
TVTDIG
P
I
I
V
I
GVG
A
Y
L
A
ISGS
I
T
V
G
T
L
-
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
----
R
V
F
Q
L
I
D--E--DY---DIKN--GVG----AQ
P
I
E
IK-QG
R
I
D
I
D
H
V
S
F
Q
Y-NDN-EA
P
I
L
K
D
I
N
L
S
I
EKG
E
T
V
A
F
V
G
MSGG
G
K
S
T
L
I
N
L
I
P
R
F
YDVT---S
G
Q
I
L
I
DGH
N
I
K
D
F
L
T
G
S
L
R
N
QIGLVQQD
N
I
L
F
S
D
T
V
K
EN
I
L
LG-R--PT---A-
T
D
E
E
-
V
V
E
A
A
K
MA
N
A
H
D
F
I
MNLPQGYD
T
E
V
GERGVKLSGGQ
K
Q
R
L
S
I
A
R
I
FLNNP
P
I
L
I
LDEATSALDL
E
S
E
-
S
I
I
Q
E
A
L
D
V
L--S--KDR
T
T
L
I
V
A
H
R
L
STITHA
D
K
I
V
V
I
ENG
H
I
V
ETG
T
H
R
E
L
I
A
--K--Q-
G
A
Y
E
H
L
Y
S
IQNL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
90.55
100%
-127
- C1 -
2HYD
3
Y1866_STAAM
B:
[1-578]
---------------------------------------------------------
M
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
L
T
----------------
T
D
E
K
V
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
--
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
-
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
--
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
-
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
----
R
V
F
Q
L
I
D
--
E
--
D
Y
---
D
I
K
N
--
G
V
G
----
A
Q
P
I
E
I
K
-
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
N
-
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
--
P
T
---
A
-
T
D
E
E
-
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
-
S
I
I
Q
E
A
L
D
V
L
--
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
--
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.55
100%
-127
- C1 -
2HYD
3
Y1866_STAAM
A:
[1-578]
---------------------------------------------------------
M
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
L
T
----------------
T
D
E
K
V
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
--
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
-
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
--
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
-
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
----
R
V
F
Q
L
I
D
--
E
--
D
Y
---
D
I
K
N
--
G
V
G
----
A
Q
P
I
E
I
K
-
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
N
-
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
--
P
T
---
A
-
T
D
E
E
-
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
-
S
I
I
Q
E
A
L
D
V
L
--
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
--
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
90.26
100%
-127
- C1 -
2ONJ
4
Y1866_STAAM
B:
[1-578]
---------------------------------------------------------
M
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
L
T
----------------
T
D
E
K
V
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
--
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
-
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
--
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
-
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
----
R
V
F
Q
L
I
D
--
E
--
D
Y
---
D
I
K
N
--
G
V
G
----
A
Q
P
I
E
I
K
-
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
N
-
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
--
P
T
---
A
-
T
D
E
E
-
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
-
S
I
I
Q
E
A
L
D
V
L
--
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
--
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
90.26
100%
-127
- C1 -
2ONJ
4
Y1866_STAAM
A:
[1-578]
---------------------------------------------------------
M
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
L
T
----------------
T
D
E
K
V
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
--
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
-
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
--
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
-
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
----
R
V
F
Q
L
I
D
--
E
--
D
Y
---
D
I
K
N
--
G
V
G
----
A
Q
P
I
E
I
K
-
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
N
-
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
--
P
T
---
A
-
T
D
E
E
-
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
-
S
I
I
Q
E
A
L
D
V
L
--
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
--
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
75.41
100%
-122
- C1 -
4A82
-
Y1866_STAAM
A:
[1-578]
---------------------------------------------------------
M
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
L
T
----------------
T
D
E
K
V
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
--
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
-
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
--
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
-
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
----
R
V
F
Q
L
I
D
--
E
--
D
Y
---
D
I
K
N
--
G
V
G
----
A
Q
P
I
E
I
K
-
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
N
-
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
--
P
T
---
A
-
T
D
E
E
-
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
-
S
I
I
Q
E
A
L
D
V
L
--
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
--
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
67.39
33%
-123
- C1 -
4RY2
-
?
A:
[157-721]
---------------------------------------------------------
M
M
V
K
F
A
G
F
L
K
P
L
K
K
T
-
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
K
F
----------------------
E
K
L
N
D
L
H
I
-
I
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
--
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
M
-
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
I
L
L
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
I
V
T
V
F
N
K
P
-
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
T
G
I
--
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
-
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
----
R
L
G
E
I
L
E
LA
T
--
E
K
---
E
L
--------------------
G
D
I
E
F
R
N
V
D
F
R
Y
-
G
L
R
-
K
-
P
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
-
N
--
E
N
---
V
-
D
M
D
E
-
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
-
N
H
I
K
D
A
I
Y
G
L
--
E
--
D
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
--
L
--
K
-
G
C
Y
F
K
M
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
66.20
33%
-109
- C1 -
4AYW
3
ABCBA_HUMAN
A:
[39-598]
-----------------------------------------------------------
R
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
V
D
----------------
Y
S
D
N
L
T
R
L
C
L
G
L
S
-
A
V
F
L
---
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
--
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
-
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
--
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
-
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
----
R
L
W
E
L
L
E
--
R
--
E
P
---
K
L
P
F
--
N
E
G
----
V
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
P
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
DD
P
S
---
S
V
T
A
E
E
-
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
-
Y
L
V
Q
E
A
L
D
R
L
--
M
--
D
G
R
T
V
L
V
I
A
H
H
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
HHSearch
65.26
30%
-111
- C1 -
3WMG
6
?
A:
[17-596]
-------------------------------------------------------------
I
F
A
L
A
W
S
S
S
A
T
M
I
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
F
T
K
S
K
S
Q
I
----------------
E
-----
G
E
T
W
K
Y
S
V
G
F
V
G
I
G
V
F
E
F
I
V
A
G
S
R
T
A
L
F
G
I
A
--
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
-
L
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
-
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
--
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
-
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
----
E
L
F
A
M
I
D
--
R
--
V
P
---
Q
Y
R
R
--
P
D
P
G
A
E
V
V
T
Q
P
L
V
L
-
K
Q
G
I
V
F
E
N
V
H
F
R
Y
-
P
T
R
M
N
V
E
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
G
-
K
--
R
D
---
A
-
T
D
E
E
-
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
-
A
L
V
Q
E
A
L
D
R
M
--
M
A
S
D
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
--
L
GP
S
-
G
F
Y
Y
Q
L
V
E
K
Q
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
65.08
33%
-109
- C1 -
4AYX
7
ABCBA_HUMAN
A:
[8-574]
-----------------------------------------------------------
R
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
V
D
----------------
Y
S
D
N
L
T
R
L
C
L
G
L
S
-
A
V
F
L
---
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
--
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
-
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
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I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
--
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
-
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
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L
M
K
G
L
G
A
G
G
----
R
L
W
E
L
L
E
--
R
--
E
P
---
K
L
P
F
--
N
E
G
----
V
I
L
N
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K
S
F
Q
G
A
L
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F
K
N
V
H
F
A
Y
-
P
A
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D
F
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L
S
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A
L
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G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
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L
D
G
H
D
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L
N
P
V
W
L
R
S
K
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V
S
Q
E
P
I
L
F
S
C
S
I
A
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N
I
A
Y
G
-
A
DD
P
S
---
S
V
T
A
E
E
-
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
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F
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T
V
V
G
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K
G
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L
L
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G
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Q
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A
L
L
K
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P
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L
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D
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A
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A
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D
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N
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-
Y
L
V
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--
M
--
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R
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T
E
Y
G
K
H
E
E
L
L
S
--
K
P-
N
-
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Fugue
65.03
30%
-109
- C1 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
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V
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D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
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L
Y
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Y
T
T
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L
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-
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-
Q
A
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N
N
G
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F
LPTGQNYT
K
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D
V
M
N
V
V
W
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Y
A
A
M
T
V
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M
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L
--
Y
V
--
A
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N
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R
L
R
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V
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S
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A
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L
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F
A
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-
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N
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K
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A
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--
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A
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----
G
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Y
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V
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--
R
--
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P
---
V
I
D
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--
S
S
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----
A
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V
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P
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G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
---
K
G
K
I
T
I
D
G
V
D
V
R
D
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N
L
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F
L
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A
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A
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--
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---
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P
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I
L
L
L
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A
T
S
A
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D
A
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-
G
I
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Q
Q
A
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A
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A
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I
I
I
A
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L
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I
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N
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D
L
I
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C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
A
--
Q
--
Q
-
G
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
GER
I
G
K
D
A
L
S
R
L
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L
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L
F
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L
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A
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L
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M
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T
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S
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A
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A
F
F
Y
G
W
Q
M
A
L
L
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I
A
I
L
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S
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Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
TDPPTMQ
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
TLGFAT
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
KISKIDSLSLAGEKKKLYGK
V
I
F
K
N
V
R
F
A
Y
PERPEIEILK
G
L
S
F
S
V
E
PG
Q
T
L
A
L
V
G
P
S
GCGKST
V
V
A
L
L
E
RFYDTL
G
G
E
I
F
I
DGSEIKTLN
P
E
H
T
R
S
Q
I
A
I
V
S
Q
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P
T
L
F
DCS
I
A
E
N
I
I
YGLDPSSVT
M
A
Q
V
E
E
A
A
R
L
A
NI
H
N
F
I
A
E
LPEGFETRVGDRGTQLS
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
NPK
I
L
L
L
D
EATSALDT
E
S
E
K
V
V
Q
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A
L
D
R
A
R
EG
R
T
C
I
V
I
A
HRLNTVMNAD
C
I
A
V
V
S
NGTII
E
K
G
T
H
T
Q
L
M
S
E
K
4
PsiBlast_PDB
64.84
39%
-113
- C1 -
3QF4
1
Y288_THEMA
B:
[105-590]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
-
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
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N
G
I
I
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D
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S
G
L
T
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L
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D
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E
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L
R
K
V
G
T
K
A
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I
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--
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
-
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
----
R
I
F
E
I
L
D
LE
E
--
E
K
---
D
D
P
D
--
A
V
E
----
L
R
E
V
----
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
-
K
K
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
--
P
G
---
A
-
T
D
E
E
-
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
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G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
-
K
S
I
Q
A
A
M
W
K
L
--
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
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E
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V
E
M
G
K
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L
I
Q
--
K
--
R
-
G
F
Y
Y
E
L
F
T
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
64.78
33%
-107
- C1 -
4S0F
2
?
B:
[161-721]
-------------------------------------------------------------
F
A
G
F
L
K
P
L
K
K
T
-
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
K
F
----------------------
E
K
L
N
D
L
H
I
-
I
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
--
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
M
-
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
I
L
L
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
I
V
T
V
F
N
K
P
-
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
YI
N
L
S
S
L
T
G
I
--
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
-
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
----
R
L
G
E
I
L
E
LA
T
--
E
K
---
E
L
R
E
--
D
S
D
----
D
F
V
I
S
L
K
--
G
D
I
E
F
R
N
V
D
F
R
Y
-
G
L
R
-
K
-
P
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
-
N
--
E
N
---
V
-
D
M
D
E
-
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
-
N
H
I
K
D
A
I
Y
G
L
--
E
--
D
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
--
L
--
K
-
G
C
Y
F
K
M
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
64.30
33%
-107
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[8-572]
-----------------------------------------------------------
R
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
V
D
----------------
Y
S
D
N
L
T
R
L
C
L
G
L
S
-
A
V
F
L
---
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
--
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
-
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
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I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
--
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
-
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
----
R
L
W
E
L
L
E
--
R
--
E
P
---
K
L
P
F
--
N
E
G
----
V
I
L
N
E
K
S
F
Q
G
A
L
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F
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N
V
H
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A
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-
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A
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S
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A
L
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G
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S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
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A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
DD
P
S
---
S
V
T
A
E
E
-
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
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N
F
P
Q
G
F
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T
V
V
G
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K
G
V
L
L
S
G
G
Q
K
Q
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A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
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A
T
S
A
L
D
A
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N
E
-
Y
L
V
Q
E
A
L
D
R
L
--
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
--
K
P----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
HHSearch
64.11
33%
-108
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[7-572]
----------------------------------------------------------
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
V
D
----------------
Y
----
S
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
--
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
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N
R
L
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S
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A
L
L
G
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N
L
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L
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A
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A
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A
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M
F
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V
V
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I
I
A
V
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Y
-
L
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L
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L
A
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N
V
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V
R
A
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T
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A
S
K
V
D
H
V
M
Q
L
A
R
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E
A
F
A
--
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
-
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
----
R
L
W
E
L
L
E
--
R
--
E
P
---
K
L
P
F
--
N
E
G
V
---
I
L
N
E
K
S
F
-
Q
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
P
E
V
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I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
--
D
D
PSS
V
-
T
A
E
E
-
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
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Q
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A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
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N
E
-
Y
L
V
Q
E
A
L
D
R
L
--
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
--
K
P----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
63.99
39%
-113
- C1 -
4Q4A
1
Y288_THEMA
B:
[105-590]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
-
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
--
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
-
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
----
R
I
F
E
I
L
D
LE
E
--
E
K
---
D
D
P
D
--
A
V
E
----
L
R
E
V
----
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
-
K
K
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
--
P
G
---
A
-
T
D
E
E
-
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
-
K
S
I
Q
A
A
M
W
K
L
--
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
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E
I
V
E
M
G
K
H
D
E
L
I
Q
--
K
--
R
-
G
F
Y
Y
E
L
F
T
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
63.79
39%
-108
- C1 -
4Q4H
-
Y288_THEMA
B:
[105-590]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
-
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
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E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
--
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
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V
G
T
I
-
A
T
F
I
G
Y
S
R
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F
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P
L
N
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L
S
N
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F
N
M
I
Q
M
A
L
A
S
A
E
----
R
I
F
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I
L
D
L
E
E
--
E
K
---
D
D
P
D
--
A
V
E
----
L
R
E
V
----
R
G
E
I
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F
K
N
V
W
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Y
--
D
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-
K
K
P
V
L
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D
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F
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A
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G
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G
K
T
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N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
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D
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L
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Y
G
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--
P
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---
A
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A
A
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A
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A
A
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--
M
--
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L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
--
K
--
R
-
G
F
Y
Y
E
L
F
T
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
63.78
33%
-108
- C1 -
4AYT
8
ABCBA_HUMAN
A:
[8-567]
-----------------------------------------------------------
R
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
V
D
----------------
Y
S
D
N
L
T
R
L
C
L
G
L
S
-
A
V
F
L
---
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
--
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
-
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
--
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
-
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
----
R
L
W
E
L
L
E
--
R
--
E
P
---
K
L
P
F
--
N
E
G
----
V
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
P
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
DD
P
S
---
S
V
T
A
E
E
-
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
-
Y
L
V
Q
E
A
L
D
R
L
--
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
63.60
34%
-103
- C1 -
4M1M
3
MDR1A_MOUSE
A:
[132-679]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
W
C
L
A
A
G
R
Q
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
-
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
K
K
A
I
T
--
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
Y
S
I
G
Q
V
-
L
T
V
--
F
F
S
V
L
I
G
A
F
S
--
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
--
N
--
K
P
---
S
I
D
S
FS
K
S
G
----
H
K
P
D
N
I
--
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
R
K
-
E
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
---
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
-
R
--
E
D
---
V
-
T
M
D
E
-
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
-
A
V
V
Q
A
A
L
D
K
A
--
R
--
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
--
E
--
K
-
G
I
Y
F
K
L
V
M
T
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
63.48
34%
-106
- C1 -
3WMG
3
?
A:
[76-595]
----------------------------------------------------------------------------------------------------------------------------------------
V
G
I
G
V
F
E
F
I
V
A
G
S
-----
R
T
A
L
F
G
I
A
--
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
-
Q
V
I
Q
Y
S
F
S
K
L
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
-
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
--
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
F
S
A
I
-
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
----
E
L
F
A
M
I
D
--
R
VP
Q
Y
RRP
D
P
G
A
--
E
V
V
----
T
Q
P
L
V
L
K
-
Q
G
-
I
V
F
E
N
V
H
F
R
Y
-
P
T
R
M
N
V
E
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
G
-
K
--
R
D
---
A
-
T
D
E
E
-
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
-
A
L
V
Q
E
A
L
D
R
M
M
A
S
--
D
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
G
P
--
S
-
G
F
Y
Y
Q
L
V
E
K
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
62.84
39%
-110
- C1 -
4Q4J
-
Y288_THEMA
B:
[105-590]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
-
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
--
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
-
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
----
R
I
F
E
I
L
D
LE
E
--
E
K
---
D
D
P
D
--
A
V
E
----
L
R
E
V
----
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
-
K
K
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
--
P
G
---
A
-
T
D
E
E
-
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
-
K
S
I
Q
A
A
M
W
K
L
--
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
--
K
--
R
-
G
F
Y
Y
E
L
F
T
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
62.70
33%
-103
- C1 -
4S0F
2
?
A:
[161-721]
-------------------------------------------------------------
F
A
G
F
L
K
P
L
K
K
T
-
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
K
F
----------------------
E
K
L
N
D
L
H
I
-
I
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
--
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
M
-
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
I
L
L
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
I
V
T
V
F
N
K
P
-
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
T
G
I
--
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
-
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
----
R
L
G
E
I
L
E
L
A
T
--
E
K
---
E
L
R
E
--
D
S
D
----
D
F
V
I
S
L
K
--
G
D
I
E
F
R
N
V
D
F
R
Y
-
G
L
R
-
K
-
P
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
-
N
--
E
N
---
V
-
D
M
D
E
-
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
-
N
H
I
K
D
A
I
Y
G
L
--
E
--
D
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
--
L
--
K
-
G
C
Y
F
K
M
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
48.84
50%
-105
- C1 -
1XEF
3
HLYBP_ECOLX
B:
[6-240]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
---
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
--
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
--
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
48.38
50%
-102
- C1 -
1XEF
3
D:
[6-240]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
---
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
--
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
--
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
HHSearch
48.28
47%
-92
- C1 -
3NH6
2
A:
[19-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
M
F
I
D
M
E
----
N
M
F
D
L
L
K
--
E
--
E
T
---
E
V
K
D
--
L
P
G
----
A
G
P
L
R
F
Q
-
K
G
R
I
E
F
E
N
V
H
F
S
Y
-
A
D
G
--
R
E
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
-
R
--
V
T
---
A
-
G
N
D
E
-
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
-
R
A
I
Q
A
S
L
A
K
V
--
C
--
A
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
--
R
--
G
-
G
V
Y
A
D
M
W
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
48.26
50%
-107
- C1 -
1XEF
3
HLYBP_ECOLX
C:
[6-240]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
---
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
--
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
--
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
48.25
50%
-100
- C1 -
2FGJ
2
HLYBP_ECOLX
C:
[12-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
---
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
--
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
--
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
48.04
47%
-91
- C1 -
3NH6
2
A:
[22-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
D
M
E
----
N
M
F
D
L
L
K
--
E
--
E
T
---
E
V
K
D
--
L
P
G
----
A
G
P
L
R
F
Q
-
K
G
R
I
E
F
E
N
V
H
F
S
Y
-
A
D
G
-
R
E
-
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
-
R
--
V
T
---
A
-
G
N
D
E
-
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
-
R
A
I
Q
A
S
L
A
K
V
--
C
--
A
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
--
R
--
G
-
G
V
Y
A
D
M
W
Q
L
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
47.86
47%
-90
- C1 -
3NH9
3
A:
[22-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
D
M
E
----
N
M
F
D
L
L
K
--
E
--
E
T
---
E
V
K
D
--
L
P
G
----
A
G
P
L
R
F
Q
-
K
G
R
I
E
F
E
N
V
H
F
S
Y
-
A
D
G
-
R
E
-
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
-
R
--
V
T
---
A
-
G
N
D
E
-
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
-
R
A
I
Q
A
S
L
A
K
V
--
C
--
A
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
--
R
--
G
-
G
V
Y
A
D
M
W
Q
L
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
47.85
50%
-104
- C1 -
2FGJ
2
D:
[12-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
---
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
--
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
--
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
47.76
50%
-103
- C1 -
1XEF
3
HLYBP_ECOLX
A:
[6-240]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
---
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
--
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
--
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
47.49
50%
-106
- C1 -
2FF7
1
A:
[5-243]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
---
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
--
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
--
E
--
P
E
S
L
Y
S
Y
L
Y
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
47.18
50%
-107
- C1 -
2PMK
1
A:
[8-242]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
---
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
--
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
--
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
46.94
50%
-106
- C1 -
2FF7
1
A:
[12-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
---
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
--
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
--
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
46.49
50%
-100
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[12-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
---
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
--
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
--
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
46.40
50%
-104
- C1 -
2FFA
2
A:
[12-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
---
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
--
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
--
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
46.40
50%
-103
- C1 -
2FGK
2
D:
[12-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
---
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
--
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
--
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
46.28
50%
-99
- C1 -
2FGJ
2
HLYBP_ECOLX
A:
[12-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
---
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
--
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
--
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
46.03
50%
-105
- C1 -
2FFB
1
A:
[12-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
---
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
--
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
--
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
45.76
47%
-93
- C1 -
3NHA
4
A:
[22-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
D
M
E
----
N
M
F
D
L
L
K
--
E
--
E
T
---
E
V
K
D
--
L
P
G
----
A
G
P
L
R
F
Q
-
K
G
R
I
E
F
E
N
V
H
F
S
Y
-
A
D
--
R
E
-
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
-
R
--
V
T
---
A
-
G
N
D
E
-
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
-
R
A
I
Q
A
S
L
A
K
V
--
C
--
A
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
--
R
--
G
-
G
V
Y
A
D
M
W
Q
L
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
45.72
47%
-94
- C1 -
3NHB
3
A:
[22-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
D
M
E
----
N
M
F
D
L
L
K
--
E
--
E
T
---
E
V
K
D
--
L
P
G
----
A
G
P
L
R
F
Q
-
K
G
R
I
E
F
E
N
V
H
F
S
Y
-
A
D
--
R
E
-
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
-
R
--
V
T
---
A
-
G
N
D
E
-
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
-
R
A
I
Q
A
S
L
A
K
V
--
C
--
A
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
--
R
--
G
-
G
V
Y
A
D
M
W
Q
L
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
45.62
50%
-103
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[12-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
---
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
--
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
--
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
45.55
50%
-102
- C1 -
2FGJ
2
HLYBP_ECOLX
B:
[12-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
---
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
--
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
--
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
45.47
41%
-95
- C1 -
3VX4
3
?
A:
[33-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
S
F
E
N
L
S
Y
K
Y
-
G
F
G
-
R
-
D
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
S
I
M
D
N
L
V
L
G
-
A
--
K
E
---
G
-
T
S
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
N
L
L
Q
M
T
--
E
--
K
--
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
--
K
--
Q
-
G
F
Y
Y
N
L
F
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
45.06
50%
-107
- C1 -
3B5J
1
A:
[8-242]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
---
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
--
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
--
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
44.71
50%
-99
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[12-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
-
K
P
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
---
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
--
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
--
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
HHSearch
44.57
37%
-89
- C1 -
3VX4
3
?
A:
[29-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
L
-
D
G
D
I
S
F
E
N
L
S
Y
K
Y
-
G
F
G
--
R
D
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
S
I
M
D
N
L
V
L
G
-
A
--
K
E
G--
T
-
S
Q
E
D
-
I
I
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
-
K
K
I
I
S
N
L
L
Q
M
-----
T
E
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
--
K
--
Q
-
G
F
Y
Y
N
L
F
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
43.96
41%
-96
- C1 -
3VX4
3
?
D:
[33-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
S
F
E
N
L
S
Y
K
Y
-
G
F
G
-
R
-
D
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
S
I
M
D
N
L
V
L
G
-
A
--
K
E
---
G
-
T
S
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
N
L
L
Q
M
T
--
E
--
K
--
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
--
K
--
Q
-
G
F
Y
Y
N
L
F
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
43.93
50%
-87
- C1 -
1MV5
2
LMRA_LACLA
B:
[6-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
D
F
A
Y
-
D
D
S
-
E
Q
-
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
--
G
D
---
Y
-
T
D
E
D
-
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
-
S
M
V
Q
K
A
L
D
S
L
--
M
--
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
--
T
--
H
-
P
L
Y
A
K
Y
V
S
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
43.58
50%
-96
- C1 -
1MV5
3
LMRA_LACLA
C:
[6-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
D
F
A
Y
-
D
D
S
-
E
Q
-
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
--
G
D
---
Y
-
T
D
E
D
-
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
-
S
M
V
Q
K
A
L
D
S
L
--
M
--
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
--
T
--
H
-
P
L
Y
A
K
Y
V
S
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
42.35
50%
-99
- C1 -
1MV5
3
LMRA_LACLA
A:
[2-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
H
V
D
F
A
Y
-
D
D
S
--
E
Q
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
-
L
--
E
G
D--
Y
-
T
D
E
D
-
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
-
S
M
V
Q
K
A
L
D
S
L
--
M
--
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
--
T
--
H
-
P
L
Y
A
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
41.68
46%
-95
- C1 -
5DGX
1
?
A:
[7-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
----
S
K
E
L
A
K
V
-
D
G
N
V
T
I
K
D
L
S
F
A
F
-
G
---
E
H
K
V
L
S
G
V
S
V
D
I
K
A
G
Q
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
Y
T
Q
H
---
E
G
E
I
L
L
D
G
V
D
T
R
E
L
T
L
E
N
L
R
S
H
L
S
I
V
S
Q
N
V
H
L
F
D
D
T
V
Y
N
N
I
A
F
G
-----
E
---
V
-
S
E
E
E
-
V
I
D
A
L
K
R
A
N
A
Y
E
F
V
Q
E
L
S
D
G
I
N
T
N
I
G
N
N
G
S
K
L
S
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
V
L
I
F
D
E
-----------------
L
E
S
L
--
T
--
K
S
C
T
T
I
V
I
A
H
R
L
S
T
V
E
N
A
D
K
I
V
V
M
D
G
G
R
V
V
E
S
G
K
H
Q
E
L
L
E
--
Q
--
G
-
G
L
Y
T
R
L
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
41.50
50%
-94
- C1 -
1MV5
3
LMRA_LACLA
A:
[6-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
D
F
A
Y
-
D
D
S
-
E
Q
-
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
--
G
D
---
Y
-
T
D
E
D
-
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
-
S
M
V
Q
K
A
L
D
S
L
--
M
--
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
--
T
--
H
-
P
L
Y
A
K
Y
V
S
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
40.79
50%
-93
- C1 -
1MV5
3
D:
[6-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
D
F
A
Y
-
D
D
S
-
E
Q
-
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
--
G
D
---
Y
-
T
D
E
D
-
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
-
S
M
V
Q
K
A
L
D
S
L
--
M
--
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
--
T
--
H
-
P
L
Y
A
K
Y
V
S
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------