@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1685: (2016-03-28 )
MYQQSSFKENLIHWFDENQREMPWRQTTNPYYIWLSEVMLQQTQVKTVIDYYHRFVERFPTVEVLSQASEDEVLKYWEGLGYYSRARNFHTAIKEVYDKYEGLVPKDPDQFKALKGVGPYTQAAVMSIAYNVPLATVDGNVFRVWSRLNDDYRDIKLQSTRKSYEQELLPYVTTEAGTFNQAMMELGALICTPKNPLCLFCPVQENCEAFDKGTFEKLPVKSKNVSKKVIEQSVFLIRNNQGQYLLQKRSEKLLHGMWQFPMFESEHARRKMTEKIGHDIQPVETPIFELKHQFTHLTWKIKVYAASGAINIETLPDDMIWFNLSDRDQYTFPVPMSKIYQFING
Atome Classification :
(25 SA)
.........10......-..-20-.....--------..--------.30........40........50........60........70........80........90........100.......110.-......120.......130.......140.....---..150.......----160...---.---...170.-----..-....180.......190.......200.......210.......220.......230.......240.......-250.-.......260.......-270-----...------.....280.......290.......300....----...310-........320.......330.......340...--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MYQ
Q
S
S
F
K
E
N
L
I
H
W
FDE-NQ-RE-MPWRQ--------TT--------N
P
Y
Y
I
W
L
S
E
V
M
L
Q
Q
T
Q
V
K
T
V
I
D
Y
Y
H
R
F
V
E
RFP
T
V
E
V
L
S
QAS
E
D
E
V
L
K
Y
W
E
GLG
Y
Y
S
R
A
R
N
F
H
T
A
I
K
E
V
Y
D
K
YEGLVPKD
P
D
Q
F
K
A
-
L
KGVG
P
Y
T
Q
A
A
V
M
S
I
A
YNV
P
L
A
TVDG
N
V
F
R
V
W
S
R
---LNDDYR
D
I
K
L
Q
S
----
T
R
K
S
Y
E
---
Q
---
E
L
L
P
Y
VT-----TE-AG
T
F
N
Q
A
M
M
ELG
A
L
I
CTPKN
P
L
C
L
FCPVQEN
C
E
AFDKGTFEKLPVKSK
N
V
S
K
K
V
I
E
Q
S
V
F
L
I
RNNQ
G
Q
Y
L
L
Q
K
R
-
S
E
-
K
-
L
L
H
G
M
W
QFPMF
E
S
E
H
A
R
-
R
K
------
M
T
E
------
K
IGHDIQPVET
P
I
F
E
L
K
H
QF
T
H
L
T
W
K
I
K
V
Y
A
A----S
G
A
I
N
--
I
E
TLPD
D
M
I
W
F
NLSDRD
Q
Y
TFPV
P
M
S
K
I
Y
Q
F
ING--
25
HHSearch
94.14
44%
-97
* C2 *
3FSP
4
?
A:
[11-359]
-
F
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
-
R
D
-
L
P
W
R
K
--------
D
R
--------
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
---
L
F
L
V
T
D
D
I
A
K
P
S
----
T
R
K
R
F
E
Q
I
V
R
---
E
I
M
A
Y
E
N
--------
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
-
D
S
T
G
-
L
L
A
N
L
W
E
F
P
S
C
E
T
D
-
G
A
-
D
G
------
K
E
K
L
E
Q
M
V
G
E
Q
Y
G
L
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
----
R
L
V
H
G
---
G
P
V
E
E
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
---
1
PsiBlast_PDB
93.74
44%
-99
- C2 -
3FSP
4
?
A:
[11-356]
-
F
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
-
R
D
-
L
P
W
R
K
--------
D
R
--------
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
---
L
F
L
V
T
D
D
I
A
K
P
S
----
T
R
K
R
F
E
---
Q
I
V
R
E
I
M
A
Y
-------
E
N
-
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
-
G
-
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
-
G
K
E
K
L
E
Q
M
V
G
E
------
Q
Y
G
L
Q
V
E
L
T
E
-
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
G
P
V
E
EP
Y
R
L
A
P
E
D
E
L
-------
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
------
4
PsiBlast_PDB
93.65
44%
-100
- C2 -
4YPH
4
?
A:
[12-356]
--
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
-
R
D
-
L
P
W
R
K
--------
D
R
--------
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
---
L
F
L
V
T
D
D
I
A
K
C
S
----
T
R
K
R
F
E
---
Q
I
V
R
E
I
M
A
Y
-------
E
N
-
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
----
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
-
G
-
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
-
G
K
E
K
L
E
Q
M
V
----------
G
L
Q
V
E
L
T
E
-
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
G
P
V
E
EP
Y
R
L
A
P
E
D
E
L
-------
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
------
3
PsiBlast_PDB
93.40
44%
-98
- C2 -
4YOQ
5
?
A:
[12-356]
--
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
-
R
D
-
L
P
W
R
K
--------
D
R
--------
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
---
L
F
L
V
T
D
D
I
A
K
C
S
----
T
R
K
R
F
E
---
Q
I
V
R
E
I
M
A
Y
-------
E
N
-
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
----
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
-
G
-
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
-
G
K
E
K
L
E
Q
M
V
----------
G
L
Q
V
E
L
T
E
-
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
G
P
V
E
EP
Y
R
L
A
P
E
D
E
L
-------
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
------
8
PsiBlast_PDB
93.17
44%
-95
- C2 -
4YPR
5
?
A:
[11-356]
-
F
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
-
R
D
-
L
P
W
R
K
--------
D
R
--------
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
---
L
F
L
V
T
D
D
I
A
K
C
S
----
T
R
K
R
F
E
---
Q
I
V
R
E
I
M
A
Y
-------
E
N
-
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
-
G
-
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
-
G
K
E
K
L
E
Q
M
V
G
E
------
Q
Y
G
L
Q
V
E
L
T
E
-
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
G
P
V
E
EP
Y
R
L
A
P
E
D
E
L
-------
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
------
5
PsiBlast_PDB
93.05
44%
-99
- C2 -
1RRS
4
?
A:
[12-356]
--
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
-
R
D
-
L
P
W
R
K
--------
D
R
--------
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
---
L
F
L
V
T
D
D
I
A
K
P
S
----
T
R
K
R
F
E
---
Q
I
V
R
E
I
M
A
Y
-------
E
N
-
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
K
---
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
-
G
-
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
-
G
K
E
K
L
E
Q
M
V
----------
G
L
Q
V
E
L
T
E
-
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
G
P
V
E
EP
Y
R
L
A
P
E
D
E
L
-------
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
------
6
PsiBlast_PDB
92.51
44%
-98
- C2 -
1VRL
5
?
A:
[12-356]
--
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
-
R
D
-
L
P
W
R
K
--------
D
R
--------
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
---
L
F
L
V
T
D
D
I
A
K
P
S
----
T
R
K
R
F
E
---
Q
I
V
R
E
I
M
A
Y
-------
E
N
-
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
-
G
-
L
L
A
N
L
W
E
F
P
S
C
E
T
D
--
D
-
G
K
E
K
L
E
Q
M
V
----------
G
L
Q
V
E
L
T
E
-
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
G
P
V
E
EP
Y
R
L
A
P
E
D
E
L
-------
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
------
48
Fugue
92.48
44%
-93
- C2 -
1RRQ
4
?
A:
[12-362]
--
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
-
R
D
-
L
P
W
R
K
--------
D
R
--------
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
---
L
F
L
V
T
D
D
I
A
K
C
S
----
T
R
K
R
F
E
---
Q
---
I
V
R
E
I
M
A
-----
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
V
----
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
-
D
S
-
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
------
K
L
E
------
Q
M
V
G
L
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
----
R
L
V
H
G
--
G
P
V
-
E
E
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
21
PsiBlast_CBE
91.52
44%
-94
- C2 -
4YPR
3
?
B:
[11-356]
-
F
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
-
R
D
-
L
P
W
R
K
--------
D
R
--------
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
---
L
F
L
V
T
D
D
I
A
K
C
S
----
T
R
K
R
F
E
---
Q
IVR
E
I
M
A
Y
-------
E
N
-
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
-
G
-
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
-
G
K
EKLEQM
V
G
-----------
Q
V
E
L
T
E
-
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
RLVH
G
G
P
V
E
EP
Y
R
L
A
P
E
D
E
L
-------
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
------
2
PsiBlast_PDB
91.49
45%
-101
- C2 -
3G0Q
4
?
A:
[5-345]
------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
-
R
D
-
L
P
W
R
K
--------
D
R
--------
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
---
L
F
L
V
T
D
D
I
A
K
C
S
----
T
R
K
R
F
E
---
Q
I
V
R
E
I
M
A
Y
-------
E
N
-
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
----
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
-
G
-
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
-
G
K
EKLEQM
V
----------
G
L
Q
V
E
L
T
E
-
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
G
P
V
E
E
P
Y
R
L
A
P
E
D
E
L
-------
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
------
7
PsiBlast_PDB
91.40
44%
-99
- C2 -
1RRQ
4
?
A:
[12-356]
--
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
-
R
D
-
L
P
W
R
K
--------
D
R
--------
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
---
L
F
L
V
T
D
D
I
A
K
C
S
----
T
R
K
R
F
E
---
Q
I
V
R
E
I
M
A
Y
-------
E
N
-
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
----
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
-
G
-
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
-
G
K
E
K
L
E
Q
M
V
----------
G
L
Q
V
E
L
T
E
-
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
G
P
V
E
E
P
Y
R
L
A
P
E
D
E
L
-------
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
------
23
PsiBlast_CBE
77.79
39%
-101
- C2 -
3N5N
2
MUTYH_HUMAN
Y:
[16-243]
----
T
A
F
R
G
S
L
L
S
W
Y
D
Q
-
E
K
-
R
D
-
L
P
W
R
R
--------
R
A
EDEMDLDR
R
A
Y
A
V
W
V
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
N
Y
Y
T
G
W
M
Q
K
W
P
T
L
Q
D
L
A
S
A
S
L
E
E
V
N
Q
L
W
A
G
L
G
Y
Y
S
R
G
R
R
L
Q
E
G
A
R
K
V
V
E
E
L
G
G
H
M
P
R
T
A
E
T
L
Q
Q
L
L
P
G
V
G
R
Y
T
A
G
A
I
A
S
I
A
F
G
Q
A
T
G
V
V
D
G
N
V
A
R
V
L
C
R
---
V
----
R
A
I
G
A
D
P
----
S
S
T
L
V
S
---
Q
---
Q
L
W
G
L
A
Q
QLVDP
A
R
-
P
G
D
F
N
Q
A
A
M
E
L
G
A
T
V
C
T
P
Q
R
P
L
C
S
Q
C
P
V
E
S
L
C
R
A
R
Q
R
V
E
Q
E
Q
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
76.98
39%
-101
- C2 -
3N5N
1
MUTYH_HUMAN
X:
[16-244]
----
T
A
F
R
G
S
L
L
S
W
Y
D
Q
-
E
K
-
R
D
-
L
P
W
R
R
--------
R
A
EDEMDLDR
R
A
Y
A
V
W
V
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
N
Y
Y
T
G
W
M
Q
K
W
P
T
L
Q
D
L
A
S
A
S
L
E
E
V
N
Q
L
W
A
G
L
G
Y
Y
S
R
G
R
R
L
Q
E
G
A
R
K
V
V
E
E
L
G
G
H
M
P
R
T
A
E
T
L
Q
Q
L
L
P
G
V
G
R
Y
T
A
G
A
I
A
S
I
A
F
G
Q
A
T
G
V
V
D
G
N
V
A
R
V
L
C
R
---
V
----
R
A
I
G
A
D
P
----
S
S
T
L
V
S
---
Q
---
Q
L
W
G
L
A
Q
QLVDP
A
R
-
P
G
D
F
N
Q
A
A
M
E
L
G
A
T
V
C
T
P
Q
R
P
L
C
S
Q
C
P
V
E
S
L
C
R
A
R
Q
R
V
E
Q
E
Q
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
75.95
41%
-95
- C2 -
3N5N
1
MUTYH_HUMAN
X:
[14-246]
--
E
V
T
A
F
R
G
S
L
L
S
W
Y
D
Q
-
E
K
-
R
D
-
L
P
W
R
R
RAEDEMDL
D
R
--------
R
A
Y
A
V
W
V
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
N
Y
Y
T
G
W
M
Q
K
W
P
T
L
Q
D
L
A
S
A
S
L
E
E
V
N
Q
L
W
A
G
L
G
Y
Y
S
R
G
R
R
L
Q
E
G
A
R
K
V
V
E
E
L
G
G
H
M
P
R
T
A
E
T
L
Q
Q
L
L
P
G
V
G
R
Y
T
A
G
A
I
A
S
I
A
F
G
Q
A
T
G
V
V
D
G
N
V
A
R
V
L
C
R
---
V
R
A
I
G
A
D
P
S
S
T
L
VSQQ
L
W
G
L
A
----
Q
---
Q
L
V
D
P
A
R
--------
P
G
D
F
N
Q
A
A
M
E
L
G
A
T
V
C
T
P
Q
R
P
L
C
S
Q
C
P
V
E
S
L
C
R
A
R
Q
R
V
E
Q
E
Q
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
75.82
42%
-85
- C2 -
1WEF
1
MUTY_ECOLI
A:
[2-222]
--
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
-
Y
G
-
R
A
T
L
P
W
Q
I
--------
D
K
--------
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
----
K
L
W
S
L
S
---
E
---
Q
V
T
P
A
V
G
-----
V
E
---
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
75.48
41%
-93
- C2 -
1KG2
6
MUTY_ECOLI
A:
[2-224]
--
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
-
Y
G
R
K
T
-
L
P
W
Q
I
--------
D
K
--------
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
---
C
Y
A
V
S
G
W
P
G
K
K
E
----
V
E
N
K
L
W
S
L
S
E
---
Q
V
T
P
A
V
G
--------
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
75.39
41%
-89
- C2 -
1KG4
4
MUTY_ECOLI
A:
[2-222]
--
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
-
K
T
-
L
P
W
Q
I
--------
D
K
--------
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
A
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
----
K
L
W
S
L
S
---
E
---
Q
V
T
P
A
V
G
-----
V
E
---
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
75.33
41%
-91
- C2 -
1KG5
6
MUTY_ECOLI
A:
[2-222]
--
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
-
K
T
-
L
P
W
Q
I
--------
D
K
--------
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
Q
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
----
K
L
W
S
L
S
---
E
---
Q
V
T
P
A
V
G
-----
V
E
---
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.89
41%
-88
- C2 -
1KG6
8
MUTY_ECOLI
A:
[2-222]
--
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
-
K
T
-
L
P
W
Q
I
--------
D
K
--------
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
R
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
----
K
L
W
S
L
S
---
E
---
Q
V
T
P
A
V
G
-----
V
E
---
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.80
41%
-87
- C2 -
1WEG
4
MUTY_ECOLI
A:
[2-222]
--
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
-
K
T
-
L
P
W
Q
I
--------
D
K
--------
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
A
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
----
K
L
W
S
L
S
---
E
---
Q
V
T
P
A
V
G
-----
V
E
---
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
74.67
41%
-86
- C2 -
1MUD
4
MUTY_ECOLI
A:
[2-222]
--
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
-
K
T
-
L
P
W
Q
I
--------
D
K
--------
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
N
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
----
K
L
W
S
L
S
---
E
---
Q
V
T
P
A
V
G
-----
V
E
---
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
74.51
41%
-88
- C2 -
1MUY
4
MUTY_ECOLI
A:
[2-222]
--
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
-
K
T
-
L
P
W
Q
I
--------
D
K
--------
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
----
K
L
W
S
L
S
---
E
---
Q
V
T
P
A
V
G
-----
V
E
---
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
74.25
41%
-83
- C2 -
1KQJ
5
MUTY_ECOLI
A:
[2-222]
--
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
-
K
T
-
L
P
W
Q
I
--------
D
K
--------
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
----
K
L
W
S
L
S
---
E
---
Q
V
T
P
A
V
G
-----
V
E
---
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
H
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
74.17
42%
-83
- C2 -
1WEI
5
MUTY_ECOLI
A:
[2-222]
--
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
-
Y
G
-
R
A
T
L
P
W
Q
I
--------
D
K
--------
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
YA-
V
S
G
W
P
G
K
K
E
V
E
N
----
K
L
W
-
L
S
---
E
---
Q
V
T
P
A
V
G
-----
V
E
---
R
F
N
Q
A
M
M
D
L
G
A
M
-
C
T
R
S
K
P
K
C
-
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
73.87
41%
-86
- C2 -
1MUN
7
MUTY_ECOLI
A:
[2-222]
--
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
-
K
T
-
L
P
W
Q
I
--------
D
K
--------
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
N
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
----
K
L
W
S
L
S
---
E
---
Q
V
T
P
A
V
G
-----
V
E
---
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------