@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1688: (2016-03-28 )
MGSSIVLKLLKVTHYYRNKQNKKWYLPFGYDAEDIDLNNISLHIYQGEALGIIGEPESSKALVGQLLAGAIKPDKGKVVCTEDLFYGYIEDQSLIHQTVEAYTAQLVQLFPYEINDHKAEQIIQYAHLGDYKTKPVNHISKAAYAQLLLSIARSSKSNIIILNHVIDYLTPQFMERAIELTNDYIENNLTIVSIGDDIDKISQVSNYIAWFSHGQLRMEGSLKQVIPSFKEHERDRLSLNSKEEIENFDLDWKKNRTRIPEMTYNFKRVERYNHAKPPKFLVRFWTLASGTILGLALMMLLIFNNIGIISITDFTNRATMQNENKDPYGEKLAYGIAFNGSVDMQGDKQVTIPKYSVVTITGENSKNYRVTADNKTYYVSKDKLEYFNPAGLYQTHSFKKLAPYMKSNYSNYYAYFNSQLHKKHSSVIKTLVPDDDNRFVASVTQQPIQLLFNDNNQLYGFVYPIVDKKELKDKFNINNNIWITKVGNGYCIANLKEDKWIYIEL
Atome Classification :
(20 SA)
------------------------.........10........20......------..30........40....--------------------------....50........60..------------......--70.....--------...80---------------.-------..--------------------------.----------------....-.90-.----------.....--------..---100.----....---..--110----------.--------------.---.--.---------.-------..----.120.......130-.......140.......150......--.160.......170.-...-...-180....-.-..190.......200.......210----........220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320..--.....330..-----.....340.......350.......360........370.......380.......390.----......400.......410.......420.......430.......440.......450.......460.......470.......480----------........490.......500...---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------M
G
S
S
I
V
L
K
L
L
K
V
T
H
Y
Y
RNKQN
K
K
W
Y
LP------FGYDAEDIDLN
N
I
S
L
H
I
Y--------------------------QG
E
A
L
G
I
IGEPE
S
S
K
A
L
V
------------
G
Q
L
L
A
G--AIKPDKG--------
K
V
V
C----------------
T
-------
E
D
--------------------------
L
----------------
F
Y
G
Y-IE
D
-
Q
----------
S
L
I
H
Q
--------
T
V
---
E
A
Y
T
----
A
Q
L
V
---
Q
L--F-P----------Y--------------E---I--N---------
D
-------
H
K
----
A
E
Q
I
I
Q
Y
A
HLGDYK-TK
P
V
N
H
I
S
K
A
A
Y
A
Q
L
L
L
S
I
A
RSSKS
N
--
I
I
I
L
N
H
V
I
D
YL
T
P
Q
F
-
M
E
R
-
A
I
E
-
L
T
N
D
Y
IE-N-N
L
T
I
V
SIGD
D
I
D
K
I
S
Q
V
S
N
Y
I
A
W
F-----SH
G
Q
L
R
MEG
S
L
K
Q
V
I
P
S
F
K
E
H
E
R
D
RLSLN
S
K
E
E
I
E
NFDLDWKKNRTRIPEMT
Y
N
F
K
R
V
E
R
YNHAK
P
P
K
F
L
V
R
F
W
TLAS
G
T
I
L
G
L
A
L
M
M
L
L
I
FNNI
G
I
I
S
I
TDFTNRATMQNEN--KDPYGE
K
L
A
Y
-----
G
I
A
FN
G
S
VDMQGD
K
Q
V
T
IP
K
Y
S
V
V
T
I
T-GENSK
N
Y
R
V
T
ADN
K
T
Y
Y
VSKDK
L
E
YFNPAGLY----QTH
S
F
K
K
L
A
P
Y
M
K
SNYS
N
Y
Y
A
Y
F
N
S
Q
L
H
K
K
H
S
S
V
I
K
T
LVPDDDN
R
F
V
A
S
V
TQQ
P
I
Q
L
L
FNDN
N
Q
L
Y
G
F
V
Y
PIV
D
K
K
E
L
K
D
KFNINN
N
I
-----------
W
I
T
KVGN
G
Y
C
I
A
NLKED
K
W
I
Y
I
EL---
52
Fugue
82.70
18%
-90
- C2 -
3TUZ
3
METN_ECOLI
H:
[23-362]
----------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
-----------------
N
V
S
L
H
V
P
--------------------------
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
------------
I
R
C
V
N
L
--
L
E
R
P
T
E
G
--------
S
V
L
V
DGQELTTL--------
S
-------
E
S
--------------------------
E
----------------
L
T
K
A
-
R
R
Q
-
I
----------
G
M
I
F
Q
HFNLLSSR
T
V
---
F
G
N
V
----
A
L
P
L
---
E
L
DN
T
-
P
----------
K
--------------
D
---
E
--
V
---------
K
-------
R
R
----
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
--
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
-
T
R
S
-
I
L
E
-
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
-----
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
--------------------------------------------------------------------
D
I
P
E
D
Y
Q
E
R
L
Q
A
--
E
P
F
T
D
C
V
P
M
L
-----
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
-------------------
N
N
N
I
I
S
A
Q
M
D
Y
A
G
-----------------------------------------------------------------------
G
V
K
F
G
I
M
L
T
E
M
H
G
--------------------------
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
-
V
K
V
E
V
---
54
Fugue
82.12
14%
-98
- C2 -
1Z47
1
?
A:
[11-355]
--------------------------
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
A
R
S
--------------------
V
R
G
V
S
F
Q
I
R
--------------------------
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
------------
L
R
L
I
A
G
--
L
E
R
P
T
K
G
--------
D
V
W
I
----------------
G
-------
G
K
--------------------------
R
----------------
V
T
D
L
-
P
P
Q
-
K
----------
R
N
V
G
L
--------
V
F
---
Q
N
Y
A
LFQH
M
T
V
Y
---
D
N
--
V
-
S
----------
F
--------------
G
---
L
--
R
E
K
RVP
K
D
E
M
D
-------
A
R
----
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
-
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
--
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
-
R
T
F
-
V
R
Q
V
H
D
E
-
M
-
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
-----
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
-----------------------------------------------
G
T
L
F
V
A
S
F
-------
I
G
E
S
N
V
W
T
R
A
V
Q
N
G
R
I
E
V
------
A
G
A
A
L
P
V
D
P
--
A
V
S
E
G
S
E
V
A
V
-----
V
V
-----------------
R
P
K
D
V
E
L
Q
-
P
A
S
E
R
E
A
H
A
Q
V
V
R
S
A
F
-------------------------------------------------
K
G
S
Y
S
A
C
W
I
R
T
K
D
G
E
V
W
E
V
H
V
P
S
A
D
----------------
R
H
R
W
S
P
G
A
W
V
H
M
N
V
T
R
W
F
-----------
I
F
P
R
-----------------------
78
HHSearch
77.76
15%
-95
- C2 -
2OLJ
4
?
A:
[22-250]
---------------------------
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
---------------------
L
E
V
L
K
G
I
N
V
H
I
R
--------------------------
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
------------
L
R
C
L
N
L
--
L
E
D
F
D
E
G
--------
E
I
I
I
----------------
D
-------
G
I
NLKAKDTN
L
N
K
V
R
E
E
-----------
V
----------------
G
M
V
F
-
Q
R
F
-
N
----------
L
F
P
H
M
--------
T
V
---
L
N
N
I
----
T
L
A
P
---
M
K
--
V
-
R
----------
K
--------------
W
P
R
E
K
--
A
---------
E
-------
A
K
----
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
--
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
-
V
L
S
-
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-----
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
HHSearch
77.35
20%
-101
* C2 *
3TUI
1
METN_ECOLI
C:
[23-255]
----------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
-----------------
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
--------------------------
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
------------
I
R
C
V
N
L
--
L
E
R
P
T
E
G
--------
S
V
L
V
----------------
D
-------
G
Q
ELTTLSESELTKARRQ----------
I
----------------
G
M
I
F
-
Q
H
F
-
N
----------
L
L
S
S
R
--------
T
V
---
F
G
N
V
----
A
L
P
L
---
E
L
--
D
-
N
----------
T
--------------
P
---
K
DE
V
---------
K
-------
R
R
----
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
--
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
-
T
R
S
-
I
L
E
-
L
L
K
D
I
N
R
R
L
-
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
-----
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
75.43
19%
-110
- C2 -
3TUI
1
METN_ECOLI
C:
[44-251]
------------------------------------------------------------------
L
N
N
V
S
L
H
V
P
--------------------------
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
------------
I
R
C
V
N
L
--
L
E
R
P
T
E
G
--------
S
V
L
V
----------------
D
-------
G
Q
--------------------------
E
----------------
L
T
T
L
-
S
E
S
-
E
LTKARRQI--
G
M
I
F
Q
--------
H
F
---
N
L
L
S
----
S
R
T
V
FGN
V
A
--
L
-
P
----------
L
--------------
E
---
L
--
D
---------
N
TPKDEVK
R
R
----
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
--
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
-
T
R
S
-
I
L
E
-
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
-----
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.28
19%
-113
- C2 -
3TUZ
1
METN_ECOLI
C:
[44-251]
------------------------------------------------------------------
L
N
N
V
S
L
H
V
P
--------------------------
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
------------
I
R
C
V
N
L
--
L
E
R
P
T
E
G
--------
S
V
L
V
----------------
D
-------
G
Q
--------------------------
E
----------------
L
T
T
L
-
S
E
S
-
E
LTKARRQI--
G
M
I
F
Q
--------
H
F
---
N
L
L
S
----
S
R
T
V
FGN
V
A
--
L
-
P
----------
L
--------------
E
---
L
--
D
---------
N
TPKDEVK
R
R
----
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
--
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
-
T
R
S
-
I
L
E
-
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
-----
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
74.81
19%
-115
- C2 -
3DHW
-
METN_ECOLI
C:
[21-228]
------------------------------------------------------------------
L
N
N
V
S
L
H
V
P
--------------------------
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
------------
I
R
C
V
N
L
--
L
E
R
P
T
E
G
--------
S
V
L
V
----------------
D
-------
G
Q
--------------------------
E
----------------
L
T
T
L
-
S
E
S
-
E
LTKARRQI--
G
M
I
F
Q
--------
H
F
---
N
L
L
S
----
S
R
T
V
FGN
V
A
--
L
-
P
----------
L
--------------
E
---
L
--
D
---------
N
TPKDEVK
R
R
----
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
--
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
-
T
R
S
-
I
L
E
-
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
-----
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
HHSearch
73.31
17%
-105
- C2 -
1G6H
3
LIVG_METJA
A:
[4-244]
--------------------------
T
M
E
I
L
R
T
E
N
I
V
K
Y
F
G
E
---------------------
F
K
A
L
D
G
V
S
I
S
V
N
--------------------------
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
------------
I
N
V
I
T
G
--
F
L
K
A
D
E
G
--------
R
V
Y
F
----------------
E
-------
N
K
--------------------------
D
ITNKE
P
A
E
L
Y
H
Y
G
I
--
V
R
T
F
-
Q
T
P
-
Q
----------
P
L
K
E
M
--------
T
V
---
L
E
N
L
----
L
I
G
E
---
I
C
--
P
-
G
ES
P
L
N
S
L
F
Y
K
K
WIPK----------
E
E
--
E
--
M
---------
V
-------
E
K
----
A
F
K
I
L
E
F
L
K
L
S
H
L
Y
-
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
N
P
K
--
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
-
A
H
D
-
I
F
N
-
H
V
L
E
L
K
A
-
K
-
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
-----
F
N
G
Q
I
I
A
E
G
R
G
E
E
E
I
K
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
HHSearch
72.42
17%
-96
- C2 -
1B0U
4
HISP_SALTY
A:
[5-244]
----------------------------
N
K
L
H
V
I
D
L
H
K
R
Y
G
G
---------------------
H
E
V
L
K
G
V
S
L
Q
A
R
--------------------------
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
------------
L
R
C
I
N
F
--
L
E
K
P
S
E
G
--------
A
I
I
V
----------------
N
-------
G
Q
NI
N
L
V
R
D
KDGQLKVAD
K
N
Q
L
R
L
L
R
T
R
L
----------------
T
M
V
F
-
Q
H
F
-
N
----------
L
W
S
H
M
--------
T
V
---
L
E
N
V
----
M
E
A
P
---
I
Q
--
V
L
G
----------
L
--------------
S
K
H
-
D
--
A
---------
R
-------
E
R
----
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
--
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
-
V
G
E
-
V
L
R
-
I
M
Q
Q
L
A
E
-
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
-----
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
71.11
24%
-95
- C2 -
3D31
-
?
A:
[8-215]
--------------------------------------------
S
R
K
W
--------------
K
N
F
S
L
D
N
L
S
L
K
V
E
--------------------------
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
------------
L
E
L
I
A
G
--
F
H
V
P
D
S
G
--------
R
I
------------------------------------------------------
L
----------------
L
D
G
K
D
V
T
D
-
L
----------
S
P
E
K
H
--------
D
I
----
A
F
V
----
Y
Q
N
Y
---
S
L
--
F
-
P
----------
H
MN
V
K
K
N
L
E
F
G
M
R
M
K
K
---
I
--
K
---------
D
-------
P
K
R
V
L
D
T
A
R
D
L
K
I
E
H
L
L
D
R
------
N
P
L
T
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
PK
I
L
L
L
D
E
P
L
S
A
L
D
P
R
T
-
Q
E
N
-
A
R
E
M
L
S
V
L
H
K
K
-
N
-
K
L
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
D
R
I
A
V
V
-----
M
D
G
K
L
I
Q
V
G
K
P
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
HHSearch
70.99
17%
-110
- C2 -
3GFO
1
ECFA3_CLOP1
A:
[4-238]
--------------------------
E
D
Y
I
L
K
V
E
E
L
N
Y
N
Y
S
D
G
--------------------
T
H
A
L
K
G
I
N
M
N
I
K
--------------------------
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
------------
F
Q
N
F
N
G
--
I
L
K
P
S
S
G
--------
R
I
L
F
----------------
D
-------
N
K
PIDYS
R
K
G
I
M
K
L
R
E
S
-----------
I
----------------
G
I
V
F
-
Q
D
P
D
N
----------
Q
L
F
S
A
--------
S
V
---
Y
Q
D
V
----
S
F
G
A
---
V
N
--
M
-
K
----------
L
--------------
P
---
E
D
E
I
---------
R
-------
K
R
----
V
D
N
A
L
K
R
T
G
I
E
H
L
K
-
D
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
--
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
-
V
S
E
-
I
M
K
-
L
L
V
E
M
Q
K
E
L
-
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
-----
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
F
A
E
K
E
V
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
HHSearch
70.58
19%
-102
- C2 -
3D31
-
?
A:
[1-220]
-----------------------------
M
I
E
I
E
S
L
S
R
K
W
K
N
----------------------
F
S
L
D
N
L
S
L
K
V
E
--------------------------
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
------------
L
E
L
I
A
G
--
F
H
V
P
D
S
G
--------
R
I
L
L
----------------
D
-------
G
K
DVTDLSPEKHD---------------
I
----------------
A
F
V
Y
-
Q
N
Y
-
S
----------
L
F
P
H
M
--------
N
V
---
K
K
N
L
----
E
F
G
M
---
R
M
--
K
-
K
----------
I
--------------
K
------
D
---------
P
-------
K
R
----
V
L
D
T
A
R
D
L
K
I
E
H
L
L
-
D
R
N
P
L
T
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
P
K
--
I
L
L
L
D
E
P
L
S
A
L
D
P
R
T
-
Q
E
N
-
A
R
E
-
M
L
S
V
L
H
K
K
N
-
K
L
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
D
R
I
A
V
V
-----
M
D
G
K
L
I
Q
V
G
K
P
E
E
I
F
E
K
P
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
70.42
19%
-69
- C2 -
4U02
1
?
A:
[12-235]
----------------------------------------------
K
W
F
G
P
------
L
H
V
------
L
K
G
I
H
L
E
V
A
--------------------------
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
RLEDFQ
E
G
E
V
V
V
D
GL
S
V
K
D
D
R
A
--------
L
R
E
I
----------------
R
-------
R
E
--------------------------
V
----------------
G
M
V
F
-
Q
Q
F
-
N
----------
L
F
P
H
M
--------
T
V
L
E
N
V
T
L
A
----
P
M
R
V
---
R
R
--
W
-
P
----------
R
--------------
E
---
K
--
A
---------
E
-------
K
K
----
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
-
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
--
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
-
V
L
D
-
V
M
R
D
L
A
Q
-
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
-----
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
-
E
R
T
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Fugue
70.06
12%
-51
- C2 -
3J16
4
RLI1_YEAST
B:
[1-608]
MS
D
K
N
S
R
I
A
I
V
S
ADKCKPKKCRQ
E
C
K
R
S
C
P
V
V
K
T
G
K
L
C
I
E
V
T
P
T
S
K
I
A
F
I
S
EILCIG
C
G
I
C
V
K
K
C
P
F
D
A
I
Q
I
I
N
L
PT
N
L
E
A
H
VTHRYSAN
S
F
K
L
H
R
L
P
T
P
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
------------
L
K
I
L
A
G
--
K
Q
K
P
N
L
G
RFDDPPE
W
Q
E
I
I
----------------
K
Y
F
RGSEL
Q
N
--------------------------
Y
----------------
F
T
K
M
-
L
E
D
-
D
I
K
A
I
I
KPQYV
D
N
I
P
R
--------
A
I
---
K
G
P
V
----
Q
K
V
G
---
E
L
--
L
-
K
----------
L
R
M------------
E
---
K
--
S
---------
P
-------
E
D
----
V
K
R
Y
I
K
I
L
Q
L
E
N
V
L
-
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
--
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
Q
-
R
L
N
-
A
A
Q
-
I
I
R
S
L
L
A
-
P
-
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
Y
G
V
PS
V
Y
G
V
V
T
L
P
A
S
V
R
E
G
I
N
I
F
L
D
G
H
I
P
A
E
N
L
R
F
R
T
E
A
L
Q
F
R
I
A
D
A
T
E
D
L
Q
N
D
S
A
S
R
A
F
S
Y
P
S
L
K
K
T
Q
G
D
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
-----
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
D
E
G
--
Q
D
I
P
K
L
N
V
S
M
K
P
Q
K
I
A
P
K
F
P
G
T
V
R
Q
L
F
F
K
K
I
R
G
Q
F
L
N
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
D
I
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
GIPA
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
K
K
T
A
F
I
V
--
E
H
D
F
I
M
A
T
Y
L
A
D
--
K
V
I
V
F
E
G
I
P
S
K
N
A
H
A
R
A
P
E
S
L
L
T
G
C
N
R
F
L
K
N
L
N
V
TFRRDPNSF
R
P
R
I
N
K
L
D
S
Q
M
D
K
E
Q
K
S
S
G
N
Y
F
F
L
D
N
TGI
65
HHSearch
69.96
20%
-98
- C2 -
2IT1
-
?
A:
[2-225]
----------------------------
V
E
I
K
L
E
N
I
V
K
K
F
G
N
---------------------
F
T
A
L
N
N
I
N
L
K
I
K
--------------------------
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
------------
L
Y
T
I
A
G
--
I
Y
K
P
T
S
G
--------
K
I
Y
F
----------------
D
-------
E
K
--------------------------
D
VTELPPKDRN
V
-----
G
L
V
F
-
Q
N
W
-
A
----------
L
Y
P
H
M
--------
T
V
---
Y
K
N
I
----
A
F
P
L
---
E
L
--
R
-
K
----------
A
--------------
P
---
R
E
E
I
---------
D
-------
K
K
----
V
R
E
V
A
K
M
L
H
I
D
K
L
L
-
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
--
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
-
R
L
E
-
V
R
A
-
E
L
K
R
L
Q
K
E
L
-
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
-----
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
69.60
12%
-77
- C2 -
1OXS
23
?
C:
[1-352]
------------------------
M
V
R
---
I
I
V
K
N
V
S
K
V
F
K
K
G
-------------------
K
V
V
A
L
D
N
V
N
I
N
I
E
--------------------------
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
------------
M
R
I
I
A
G
--
L
D
V
P
S
T
G
--------
E
L
Y
F
DDRLVASNGKLIVPPE
D
-------
R
K
--------------------------
I
----------------
G
M
V
F
-
Q
T
W
-
A
----------
L
Y
P
N
L
--------
T
A
---
F
E
N
I
----
A
F
P
L
---
T
N
MK
M
-
S
----------
K
--------------
E
---
E
--
I
---------
R
-------
K
R
----
V
E
E
V
A
K
I
L
D
I
H
H
V
L
-
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
--
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
-
R
D
S
A
R
A
L
-
V
K
E
V
Q
S
R
-
L
-
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
-----
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
-----------------------------------------------
I
Q
V
A
S
L
------------------
I
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
FP
V
S
V
S
S
D
R
A
I
I
-----
G
I
-----------------
R
P
E
D
V
K
L
S
-
K
D
V
I
K
D
-----------------------------------------------------
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
E
E
I
F
T
Y
S
D
H
P
I
H
S
--------------------------------------
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
---
4
PsiBlast_PDB
69.17
19%
-71
- C2 -
4U00
3
?
A:
[12-235]
----------------------------------------------
K
W
F
G
P
------
L
H
V
------
L
K
G
I
H
L
E
V
A
--------------------------
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
RLEDFQ
E
G
E
V
V
V
D
GL
S
V
K
D
D
R
A
--------
L
R
E
I
----------------
R
-------
R
E
--------------------------
V
----------------
G
M
V
F
-
Q
Q
F
-
N
----------
L
F
P
H
M
--------
T
V
L
E
N
V
T
L
A
----
P
M
R
V
---
R
R
--
W
-
P
----------
R
--------------
E
---
K
--
A
---------
E
-------
K
K
----
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
-
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
--
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
-
V
L
D
-
V
M
R
D
L
A
Q
-
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
-----
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
-
E
R
T
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
69.12
16%
-95
- C2 -
1Z47
1
?
A:
[12-238]
---------------------------
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
--------------------
A
R
S
V
R
G
V
S
F
Q
I
R
--------------------------
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
------------
L
R
L
I
A
G
--
L
E
R
P
T
K
G
--------
D
V
W
I
----------------
G
-------
G
K
RVTDLPPQKRN---------------
V
----------------
G
L
V
F
-
Q
N
Y
-
A
----------
L
F
Q
H
M
--------
T
V
---
Y
D
N
V
----
S
F
G
L
---
R
E
--
K
-
R
----------
V
--------------
P
---
K
D
E
M
---------
D
-------
A
R
----
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
-
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
--
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
-
R
R
E
-
L
R
T
-
F
V
R
Q
V
H
D
E
M
-
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
-----
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
HHSearch
68.61
15%
-95
- C2 -
1OXX
21
?
K:
[1-232]
---------------------------
M
V
R
I
I
V
K
N
V
S
K
V
F
K
K
G
-------------------
K
V
V
A
L
D
N
V
N
I
N
I
E
--------------------------
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
------------
M
R
I
I
A
G
--
L
D
V
P
S
T
G
--------
E
L
Y
F
----------------
D
-------
D
R
--------------------------
L
VASNGKLIVPPEDRKI
G
M
V
F
-
Q
T
W
-
A
----------
L
Y
P
N
L
--------
T
A
---
F
E
N
I
----
A
F
P
L
---
T
N
--
M
-
K
----------
M
--------------
S
---
K
EE
I
---------
R
-------
K
R
----
V
E
E
V
A
K
I
L
D
I
H
H
V
L
-
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
--
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
-
R
D
S
-
A
R
A
-
L
V
K
E
V
Q
S
R
L
-
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
-----
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
HHSearch
68.56
16%
-99
- C2 -
2NQ2
-
Y1470_HAEIN
C:
[2-218]
---------------------------
N
K
A
L
S
V
E
N
L
G
F
Y
Y
Q
A
E
--------------------
N
F
L
F
Q
Q
L
N
F
D
L
N
--------------------------
K
G
D
I
L
A
V
L
G
Q
N
G
C
G
K
S
T
L
------------
L
D
L
L
L
G
--
I
H
R
P
I
Q
G
--------
K
I
E
V
----------------
Y
-------
Q
S
--------------------------
I
----------------
G
F
V
P
-
Q
F
F
-
S
----------
S
P
F
A
Y
--------
S
V
---
L
D
I
V
----
L
M
G
R
---
S
T
--
H
-
I
NTFA------
K
PK------------
S
---
H
--
D
---------
Y
-------
Q
V
----
A
M
Q
A
L
D
Y
L
N
L
T
H
L
A
-
K
R
E
F
T
S
L
S
G
G
Q
R
Q
L
I
L
I
A
R
A
I
A
S
E
C
K
--
L
I
L
L
D
E
P
T
S
A
L
D
L
A
N
-
Q
D
I
-
V
L
S
-
L
L
I
D
L
A
Q
S
Q
-
N
M
T
V
V
F
T
T
H
Q
P
N
Q
V
V
A
I
A
N
K
T
L
L
L
-----
N
K
Q
N
F
-
K
F
G
E
T
R
N
I
L
T
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------