@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1711: (2016-03-28 )
MTERRIIHIDMDYFFAQVEMRDNPKLKGKPVIVGGKASSRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAYRETSAQIMSIFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNKPDGLTVIDYQNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKSSRVRKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIYNIAYLLYNDLKDPDVPIRLIGVTVGNLEQSTYKNMTIYDFI
Atome Classification :
(92 SA)
-----------------------------------------------------------------.........10........20........30..---..---....40........50........60........70....----------------------------------.-...80........-90........100.......110.....--------------------------------------------------..---------------120------------------.........130.......140.......150.......160....--...170....--..-.180.......190....-------...200.......210......----.------------------220..----......230.......240.......250-....---...260....-...270.......280-----........290...----....300....-----..--.310--........320....------.---..330---........340.......350....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------MTE
R
R
I
I
H
I
D
M
D
Y
F
F
A
Q
V
E
MRDNPKLKGK
P
V
I
V
---GG---KASSR
G
V
V
STASY
E
A
R
KYGVHSAM
P
M
S
Q
A
H
KLCPN
G
Y
F
VT----------------------------------S-NFGA
Y
R
E
T
S
A
Q
I
M
-
S
I
F
R
S
Y
TDKVEPM
S
L
D
E
A
Y
L
D
I
T
E
LVRP--------------------------------------------------DL---------------
P
--------------------
A
S
K
I
A
Q
Y
I
R
K
D
I
L
E
QTHLTASAGV
S
Y
N
K
F
L
A
K
L
A
SGMNKPD
G
L
T
V
I
--
D
YQN
V
H
D
I
L
M
--
T
L
-DIGDFPGVG
K
A
S
K
K
VMHD-------NGIFNG
R
D
L
Y
E
K
T
E
F
E
L
I
R
L
F
G
----K------------------R-GRG----
L
Y
N
KARGI
D
H
S
E
V
K
S
S
R
V
R
K
SVGTER
T
F
A-TDVN---
D
D
E
E
I
L
R
K
V
W
-
E
LSG
K
T
A
E
R
L
N
K
L
Q
K------SA
K
T
V
T
V
K
I
K
T
Y
Q
F
----
E
T
L
S
K
Q
M
S
LRD-----SV--SSE---
E
D
I
Y
N
I
A
Y
L
L
Y
NDLK------D---PDV
P
----
I
R
L
I
G
V
T
VGNLEQSTYK
N
M
T
I
Y
DFI
107
Fugue
91.62
36%
-88
- C3 -
2W7O
5
POLK_HUMAN
A:
[15-501]
KEK
I
N
K
I
I
M
E
A
T
KGS
R
F
Y
G
N
E
L
K
K
E
K
Q
V
N
Q
R
I
E
N
M
M
Q
Q
K
A
Q
IT
S
Q
Q
L
R
K
A
Q
L
Q
V
D
R
F
A
M
E
L
E
Q
S
R
N
L
S
N
T
I
V
H
I
D
M
D
A
F
Y
A
A
V
E
M
R
D
N
P
E
L
K
D
K
P
I
A
V
---
G
S
-------
M
S
M
L
S
T
S
N
Y
H
A
R
R
F
G
V
R
A
A
M
P
G
F
I
A
K
R
L
C
P
Q
L
I
I
V
P
----------------------------------
P
-
N
F
D
K
Y
R
A
V
S
K
E
V
K
-
E
I
L
A
D
Y
D
P
N
F
M
A
M
S
L
D
E
A
Y
L
N
I
T
K
H
L
E
E
R
Q
NWPEDKRRYFIKQN
S
V
V
F
------------------------------
G
T
---------------
S
--------------------
A
Q
E
V
V
K
E
I
R
F
R
I
E
Q
K
T
T
L
T
A
S
A
G
I
A
P
N
T
M
L
A
K
V
C
S
D
K
N
K
P
N
G
Q
Y
Q
I
L
P
N
R
Q
A
V
M
D
F
I
K
--
D
L
-
P
I
R
K
V
S
G
I
G
K
V
T
E
K
M
L
K
A
-------
L
G
I
I
T
C
T
E
L
Y
Q
Q
R
A
L
L
S
L
L
F
S
E
----
T
------------------
S
-
W
H
Y
----
F
L
H
I
S
L
G
L
G
S
T
H
L
T
R
D
G
E
R
K
S
M
S
V
E
R
T
F
--
S
E
I
N
---
K
A
E
E
Q
Y
S
L
C
Q
-
E
L
C
S
E
L
A
Q
D
L
Q
K
E
R
L
------
K
G
R
T
V
T
I
K
L
K
N
V
N
F
----
E
V
K
T
R
A
S
T
V
S
S
-----
V
V
--
S
T
A
---
E
E
I
F
A
I
A
K
E
L
L
K
T
E
I
------
D
---
A
D
F
P
HPLR
L
R
L
M
G
V
R
I
S
S
F
P
N
E
-----------
104
Fugue
90.97
36%
-87
- C3 -
2OH2
4
POLK_HUMAN
A:
[15-499]
KE
K
I
N
K
I
I
M
E
A
T
KGS
R
F
Y
G
N
E
L
K
K
E
K
Q
V
N
Q
R
I
E
N
M
M
Q
Q
K
A
Q
IT
S
Q
Q
L
R
K
A
Q
L
Q
V
D
R
F
A
M
E
L
E
Q
S
R
N
L
S
N
T
I
V
H
I
D
M
D
A
F
Y
A
A
V
E
M
R
D
N
P
E
L
K
D
K
P
I
A
V
---
G
S
-------
M
S
M
L
S
T
S
N
Y
H
A
R
R
F
G
V
R
A
A
M
P
G
F
I
A
K
R
L
C
P
Q
L
I
I
V
P
----------------------------------
P
-
N
F
D
K
Y
R
A
V
S
K
E
V
K
-
E
I
L
A
D
Y
D
P
N
F
M
A
M
S
L
D
E
A
Y
L
N
I
T
K
H
L
E
E
R
Q
N
WPEDKR
R
Y
F
I
KN
S
V
V
F
-------------------------------
G
T
---------------
S
--------------------
A
Q
E
V
V
K
E
I
R
F
R
I
E
Q
K
T
T
L
T
A
S
A
G
I
A
P
N
T
M
L
A
K
V
C
S
D
K
N
K
P
N
G
Q
Y
Q
I
L
P
N
R
Q
A
V
M
D
F
I
K
--
D
L
-
P
I
R
K
V
S
G
I
G
K
V
T
E
K
M
L
K
A
-------
L
G
I
I
T
C
T
E
L
Y
Q
Q
R
A
L
L
S
L
L
F
S
E
----
T
------------------
S
-
W
H
Y
----
F
L
H
I
S
L
G
L
G
S
T
H
L
T
R
D
G
E
R
K
S
M
S
V
E
R
T
F
--
S
E
I
N
---
K
A
E
E
Q
Y
S
L
C
Q
-
E
L
C
S
E
L
A
Q
D
L
Q
K
E
R
L
------
K
G
R
T
V
T
I
K
L
K
N
V
N
F
----
E
V
K
T
R
A
S
T
V
S
S
-----
V
V
--
S
T
A
---
E
E
I
F
A
I
A
K
E
L
L
K
T
E
I
------
D
---
A
D
F
P
HPLR
L
R
L
M
G
V
R
I
S
S
F
P
-------------
115
HHSearch
90.69
31%
-88
- C3 -
3OSN
6
POLI_HUMAN
A:
[26-414]
------------------------------------------------------------------
S
S
R
V
I
V
H
V
D
L
D
C
F
Y
A
Q
V
E
M
I
S
N
P
E
L
K
D
K
P
L
G
V
---
Q
Q
-------
K
Y
L
V
V
T
C
N
Y
E
A
R
K
L
G
V
K
K
L
M
N
V
R
D
A
K
E
K
C
P
Q
L
V
L
V
N
----------------------------------
G
E
D
L
T
R
Y
R
E
M
S
Y
K
V
T
-
E
L
L
E
E
F
S
P
V
V
E
R
L
G
F
D
E
N
F
V
D
L
T
E
M
V
E
K
R
L
Q
Q
LQSDELSA
V
T
V
S
G
HV-------------------------------
Y
N
N
Q
S
I
N
LLD
V
L
H
I
R
L
L
V
--------------------
G
S
Q
I
A
A
E
M
R
E
A
M
Y
N
Q
L
G
L
T
G
C
A
G
V
A
S
N
K
L
L
A
K
L
V
S
G
V
F
K
P
N
Q
Q
T
V
L
--
L
P
E
S
C
Q
H
L
I
H
--
S
L
N
H
I
K
E
I
P
G
I
G
Y
K
T
A
K
C
L
E
A
-------
L
G
I
N
S
V
R
D
L
Q
T
F
S
P
K
I
L
E
K
E
L
G
----
I
------------------
S
V
A
Q
R
----
I
Q
K
L
S
F
G
E
D
N
S
P
V
I
L
S
G
P
P
Q
S
F
S
E
E
D
S
F
K
-
K
-
C
S
---
S
E
V
E
A
K
N
K
I
E
-
E
L
L
A
S
L
L
N
R
V
C
Q
D
G
R
------
K
P
H
T
V
R
L
I
I
R
R
Y
S
S
E
K
H
Y
G
R
E
S
R
Q
C
P
I
P
S
HVIQK------
Y
D
V
M
T
P
M
V
D
I
L
M
K
L
F
R
N
M
V
------
N
VKM
P
F
-
H
----
L
T
L
L
S
V
C
F
C
N
L
K
-------------
1
PsiBlast_PDB
86.20
45%
-80
- C3 -
4IR1
5
DPO4_ECOLI
F:
[3-300]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
---
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
----------------------------------
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------------------------------------
H
G
---------------
S
--------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
--
T
P
A
E
V
P
A
F
L
Q
--
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
-------
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
----
K
------------------
F
-
G
R
I
----
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
-
E
D
I
H
HWS
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
------
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
----
T
T
----------------------------------------------------------------------------------
21
PsiBlast_CBE
85.84
45%
-78
- C3 -
4Q43
5
DPO4_ECOLI
F:
[3-300]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
---
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
----------------------------------
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------------------------------------
H
G
---------------
S
--------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
--
T
P
A
E
V
P
A
F
L
Q
--
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
-------
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
----
K
------------------
F
-
G
R
I
----
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
-
E
D
I
H
HWS
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
------
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
----
T
T
----------------------------------------------------------------------------------
4
PsiBlast_PDB
85.84
45%
-80
- C3 -
4R8U
4
DPO4_ECOLI
A:
[2-299]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
---
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
----------------------------------
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------------------------------------
H
G
---------------
S
--------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
--
T
P
A
E
V
P
A
F
L
Q
--
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
-------
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
----
K
------------------
F
-
G
R
I
----
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
-
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
------
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
----
T
T
----------------------------------------------------------------------------------
27
PsiBlast_CBE
85.81
45%
-77
- C3 -
4IRK
4
DPO4_ECOLI
A:
[3-300]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
---
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
----------------------------------
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------------------------------------
H
G
---------------
S
--------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
--
T
P
A
E
V
P
A
F
L
Q
--
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
-------
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
----
K
------------------
F
-
G
R
I
----
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
-
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
------
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
----
T
T
----------------------------------------------------------------------------------
116
HHSearch
85.79
26%
-77
- C3 -
3MFI
7
POLH_YEAST
A:
[29-517]
------------------------------------------------------------------
S
L
A
C
I
A
H
I
D
M
N
A
F
F
A
Q
V
E
Q
M
R
C
G
L
S
K
E
D
P
V
V
C
---
V
Q
-------
W
N
S
I
I
A
V
S
Y
A
A
R
K
Y
G
I
S
R
M
D
T
I
Q
E
A
L
K
K
C
S
N
L
I
P
I
H
T
A
VFKKGED
F
W
Q
Y
HDGCGSWVQDPAKQISVED
H
K
V
-
S
L
E
P
Y
R
R
E
S
R
K
A
L
-
A
I
F
K
W
A
C
D
L
V
E
R
A
S
I
D
E
V
F
L
D
L
G
R
I
C
F
N
M
L
M
FDNEYELTGDLK
L
K
D
A
L
S
N
I
R
E
A
F
I
G
GNYDINSHLPLIPEKIKS
L
K
F
E
G
---------------
D
VFNPEGRDLITD
W
D
D
V
I
L
A
L
G
S
Q
V
C
K
G
I
R
D
S
I
K
D
I
L
G
Y
T
T
S
C
G
L
S
S
T
K
N
V
C
K
L
A
S
N
Y
K
K
P
D
A
Q
T
I
V
--
K
N
D
C
L
L
D
F
L
D
CG
K
F
-
E
I
T
S
F
W
T
L
G
G
V
L
G
K
E
L
I
D
V
L
DLPHE
N
S
I
K
H
I
R
E
T
W
P
D
N
A
G
Q
L
K
E
F
L
D
----
A
K
V
K
QSDYDSNIDPLK
T
A
D
L
-
A
E
K
----
L
F
K
L
S
R
G
R
Y
G
L
P
L
S
S
R
P
V
V
K
S
M
M
S
N
K
N
L
R
G
K
S
C
N
---
S
I
V
D
C
I
S
W
L
E
-
V
F
C
A
E
L
T
S
R
I
Q
D
L
E
Q
E
Y
N
K
I
V
I
P
R
T
V
S
I
S
L
K
T
K
S
Y
----
E
V
Y
R
K
S
G
P
V
A
Y
-----
K
G
IN
F
Q
S
---
H
E
L
L
K
V
G
I
K
F
V
T
D
L
D
I
K
G
KNK
S
---
Y
Y
-
P
----
L
T
K
L
S
M
T
I
T
N
F
D
I
I
D
----------
6
PsiBlast_PDB
85.59
45%
-78
- C3 -
4IRD
5
DPO4_ECOLI
F:
[3-300]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
---
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
----------------------------------
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------------------------------------
H
G
---------------
S
--------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
--
T
P
A
E
V
P
A
F
L
Q
--
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
-------
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
----
K
------------------
F
-
G
R
I
----
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
-
E
D
I
H
HWS
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
------
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
----
T
T
----------------------------------------------------------------------------------
24
PsiBlast_CBE
85.35
45%
-83
- C3 -
4R8U
4
?
B:
[1-298]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
---
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
----------------------------------
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------------------------------------
H
G
---------------
S
--------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
--
T
P
A
E
V
P
A
F
L
Q
--
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
-------
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
----
K
------------------
F
-
G
R
I
----
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
-
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
------
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
----
T
T
----------------------------------------------------------------------------------
8
PsiBlast_PDB
85.29
45%
-80
- C3 -
4Q44
6
DPO4_ECOLI
A:
[3-300]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
---
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
----------------------------------
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------------------------------------
H
G
---------------
S
--------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
--
T
P
A
E
V
P
A
F
L
Q
--
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
-------
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
----
K
------------------
F
-
G
R
I
----
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
-
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
------
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
----
T
T
----------------------------------------------------------------------------------
9
PsiBlast_PDB
85.20
45%
-79
- C3 -
4Q45
5
DPO4_ECOLI
F:
[3-300]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
---
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
----------------------------------
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------------------------------------
H
G
---------------
S
--------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
--
T
P
A
E
V
P
A
F
L
Q
--
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
-------
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
----
K
------------------
F
-
G
R
I
----
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
-
E
D
I
H
HWS
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
------
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
----
T
T
----------------------------------------------------------------------------------
5
PsiBlast_PDB
85.19
45%
-76
- C3 -
4IRC
5
DPO4_ECOLI
F:
[3-300]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
---
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
----------------------------------
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------------------------------------
H
G
---------------
S
--------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
--
T
P
A
E
V
P
A
F
L
Q
--
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
-------
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
----
K
------------------
F
-
G
R
I
----
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
-
E
D
I
H
HWS
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
------
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
----
T
T
----------------------------------------------------------------------------------
2
PsiBlast_PDB
85.12
45%
-77
- C3 -
4IR9
5
DPO4_ECOLI
F:
[3-300]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
---
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
----------------------------------
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------------------------------------
H
G
---------------
S
--------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
--
T
P
A
E
V
P
A
F
L
Q
--
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
-------
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
----
K
------------------
F
-
G
R
I
----
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
-
E
D
I
H
HWS
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
------
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
----
T
T
----------------------------------------------------------------------------------
3
PsiBlast_PDB
84.96
45%
-77
- C3 -
4Q43
7
DPO4_ECOLI
A:
[3-300]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
---
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
----------------------------------
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------------------------------------
H
G
---------------
S
--------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
--
T
P
A
E
V
P
A
F
L
Q
--
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
-------
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
----
K
------------------
F
-
G
R
I
----
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
-
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
------
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
----
T
T
----------------------------------------------------------------------------------
25
PsiBlast_CBE
84.84
45%
-79
- C3 -
4Q45
7
DPO4_ECOLI
A:
[3-300]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
---
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
----------------------------------
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------------------------------------
H
G
---------------
S
--------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
--
T
P
A
E
V
P
A
F
L
Q
--
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
-------
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
----
K
------------------
F
-
G
R
I
----
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
-
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
------
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
----
T
T
----------------------------------------------------------------------------------
7
PsiBlast_PDB
84.46
45%
-77
- C3 -
4IRK
5
DPO4_ECOLI
B:
[3-300]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
---
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
----------------------------------
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------------------------------------
H
G
---------------
S
--------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
--
T
P
A
E
V
P
A
F
L
Q
--
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
-------
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
----
K
------------------
F
-
G
R
I
----
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
-
E
D
I
H
HWS
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
------
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
----
T
T
----------------------------------------------------------------------------------
29
PsiBlast_CBE
84.39
45%
-84
- C3 -
4IRC
7
DPO4_ECOLI
A:
[3-300]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
---
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
----------------------------------
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------------------------------------
H
G
---------------
S
--------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
--
T
P
A
E
V
P
A
F
L
Q
--
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
-------
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
----
K
------------------
F
-
G
R
I
----
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
-
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
------
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
----
T
T
----------------------------------------------------------------------------------
26
PsiBlast_CBE
84.36
45%
-78
- C3 -
4Q44
5
DPO4_ECOLI
F:
[3-300]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
---
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
----------------------------------
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------------------------------------
H
G
---------------
S
--------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
--
T
P
A
E
V
P
A
F
L
Q
--
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
-------
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
----
K
------------------
F
-
G
R
I
----
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
-
E
D
I
H
HWS
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
------
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
----
T
T
----------------------------------------------------------------------------------
23
PsiBlast_CBE
84.16
45%
-81
- C3 -
4IR1
7
DPO4_ECOLI
A:
[3-300]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
---
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
----------------------------------
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------------------------------------
H
G
---------------
S
--------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
--
T
P
A
E
V
P
A
F
L
Q
--
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
-------
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
----
K
------------------
F
-
G
R
I
----
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
-
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
------
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
----
T
T
----------------------------------------------------------------------------------
22
PsiBlast_CBE
83.85
45%
-80
- C3 -
4IR9
7
DPO4_ECOLI
A:
[3-300]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
---
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
----------------------------------
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------------------------------------
H
G
---------------
S
--------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
--
T
P
A
E
V
P
A
F
L
Q
--
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
-------
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
----
K
------------------
F
-
G
R
I
----
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
-
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
------
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
----
T
T
----------------------------------------------------------------------------------
28
PsiBlast_CBE
83.57
45%
-81
- C3 -
4IRD
7
DPO4_ECOLI
A:
[3-300]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
---
G
G
---
S
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
----------------------------------
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
--------------------------------------------------
H
G
---------------
S
--------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
--
T
P
A
E
V
P
A
F
L
Q
--
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
-------
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
----
K
------------------
F
-
G
R
I
----
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
-
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
I
------
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
----
T
T
----------------------------------------------------------------------------------
63
PsiBlast_CBE
82.65
34%
-82
- C3 -
2IMW
11
DPO4_SULSO
P:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
KAKY
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
55
PsiBlast_CBE
82.53
34%
-78
- C3 -
2UVU
6
DPO4_SULSO
A:
[9-341]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
A
I
G
V
-------------------
40
PsiBlast_CBE
82.52
34%
-76
- C3 -
4FBT
6
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
52
PsiBlast_CBE
82.49
34%
-80
- C3 -
3V6J
5
DPO4_SULSO
A:
[9-341]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
41
PsiBlast_CBE
82.48
34%
-80
- C3 -
3T5L
6
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
60
PsiBlast_CBE
82.46
34%
-81
- C3 -
4QW9
6
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
34
PsiBlast_CBE
82.42
34%
-79
- C3 -
4JV2
5
DPO4_SULSO
A:
[9-341]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
54
PsiBlast_CBE
82.40
34%
-80
- C3 -
3V6H
7
DPO4_SULSO
A:
[9-341]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
49
PsiBlast_CBE
82.35
34%
-78
- C3 -
2AGP
9
DPO4_SULSO
B:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
KAKY
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
11
PsiBlast_PDB
82.30
34%
-80
- C3 -
4QWB
13
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
A
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
57
PsiBlast_CBE
82.27
34%
-81
- C3 -
4QWE
6
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
16
PsiBlast_PDB
82.22
34%
-78
- C3 -
2AGP
6
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
80
PsiBlast_CBE
82.18
34%
-83
- C3 -
3KHR
7
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
15
PsiBlast_PDB
82.14
34%
-80
- C3 -
2AGO
7
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
89
PsiBlast_CBE
82.11
34%
-81
- C3 -
3GIL
6
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
59
PsiBlast_CBE
82.11
34%
-81
- C3 -
4QWA
6
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
20
PsiBlast_PDB
82.10
34%
-76
- C3 -
3T5K
6
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
31
PsiBlast_CBE
82.09
34%
-84
- C3 -
4QWC
8
?
D:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
KAKY
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
92
PsiBlast_CBE
82.00
34%
-79
- C3 -
3GIJ
6
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
81
PsiBlast_CBE
81.99
34%
-85
- C3 -
3KHL
7
DPO4_SULSO
B:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
KAKY
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
79
PsiBlast_CBE
81.99
34%
-85
- C3 -
3KHR
7
DPO4_SULSO
B:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
KAKY
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
33
PsiBlast_CBE
81.89
34%
-80
- C3 -
4RUA
4
?
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
35
PsiBlast_CBE
81.85
34%
-80
- C3 -
4JV1
6
DPO4_SULSO
A:
[9-341]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
78
PsiBlast_CBE
81.84
34%
-83
- C3 -
3RAQ
7
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
77
PsiBlast_CBE
81.82
34%
-80
- C3 -
3RAQ
7
DPO4_SULSO
B:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
KAKY
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
19
PsiBlast_PDB
81.80
34%
-81
- C3 -
3T5J
6
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
71
PsiBlast_CBE
81.71
34%
-78
- C3 -
3RB4
6
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
100
PsiBlast_CBE
81.70
34%
-81
- C3 -
4GC7
10
?
B:
[10-342]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
KAKY
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
18
PsiBlast_PDB
81.67
34%
-80
- C3 -
3T5H
6
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
50
PsiBlast_CBE
81.62
34%
-84
- C3 -
4TQR
7
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
67
PsiBlast_CBE
81.56
34%
-81
- C3 -
3RBD
7
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
37
PsiBlast_CBE
81.53
34%
-79
- C3 -
4JUZ
5
DPO4_SULSO
A:
[9-341]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
51
PsiBlast_CBE
81.50
34%
-76
- C3 -
3V6J
5
DPO4_SULSO
J:
[9-341]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
KAKY
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
84
PsiBlast_CBE
81.48
34%
-84
- C3 -
3KHH
7
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
32
PsiBlast_CBE
81.48
34%
-79
- C3 -
4RUC
4
?
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
97
PsiBlast_CBE
81.46
34%
-81
- C3 -
4TQS
6
DPO4_SULSO
A:
[9-341]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
61
PsiBlast_CBE
81.44
34%
-84
- C3 -
4QW8
6
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
17
PsiBlast_PDB
81.43
34%
-77
- C3 -
2AGQ
6
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
69
PsiBlast_CBE
81.37
34%
-82
- C3 -
3RB6
7
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
14
PsiBlast_PDB
81.37
34%
-84
- C3 -
4QWC
8
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
91
PsiBlast_CBE
81.33
34%
-75
- C3 -
3GIJ
6
DPO4_SULSO
B:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
KAKY
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
68
PsiBlast_CBE
81.33
34%
-81
- C3 -
3RB6
6
DPO4_SULSO
B:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
KAKY
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
76
PsiBlast_CBE
81.30
34%
-80
- C3 -
3RAX
6
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
46
PsiBlast_CBE
81.23
34%
-77
- C3 -
3PW2
6
DPO4_SULSO
A:
[9-341]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
93
PsiBlast_CBE
81.22
34%
-78
- C3 -
3GII
7
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
75
PsiBlast_CBE
81.17
34%
-79
- C3 -
3RAX
6
DPO4_SULSO
B:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
KAKY
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
98
PsiBlast_CBE
81.13
34%
-82
- C3 -
4RZR
8
?
D:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
KAKY
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
86
PsiBlast_CBE
81.11
34%
-81
- C3 -
3KHG
8
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
56
PsiBlast_CBE
81.08
34%
-82
- C3 -
2UVR
6
DPO4_SULSO
A:
[9-341]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
A
I
G
V
-------------------
72
PsiBlast_CBE
81.02
34%
-76
* C3 *
3RB3
7
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
36
PsiBlast_CBE
81.00
34%
-80
- C3 -
4JV0
5
DPO4_SULSO
A:
[9-341]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
87
PsiBlast_CBE
80.77
34%
-84
- C3 -
3GIM
6
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
45
PsiBlast_CBE
80.73
34%
-78
- C3 -
3PW4
6
DPO4_SULSO
A:
[9-341]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
53
PsiBlast_CBE
80.69
34%
-79
- C3 -
3V6H
6
DPO4_SULSO
B:
[9-341]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
44
PsiBlast_CBE
80.62
34%
-76
- C3 -
3PW5
6
DPO4_SULSO
A:
[9-341]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
88
PsiBlast_CBE
80.59
34%
-81
- C3 -
3GIL
6
DPO4_SULSO
B:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
KAKY
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
82
PsiBlast_CBE
80.51
34%
-82
- C3 -
3KHL
7
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
42
PsiBlast_CBE
80.44
34%
-78
- C3 -
3PW7
4
DPO4_SULSO
E:
[9-341]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
KAKY
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
43
PsiBlast_CBE
80.20
34%
-80
- C3 -
3PW7
4
DPO4_SULSO
A:
[9-341]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
65
PsiBlast_CBE
80.13
34%
-81
- C3 -
3RBE
6
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
74
PsiBlast_CBE
80.11
34%
-78
- C3 -
3RB0
6
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
47
PsiBlast_CBE
79.98
34%
-79
- C3 -
3PW0
6
DPO4_SULSO
A:
[9-341]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
90
PsiBlast_CBE
79.82
34%
-79
- C3 -
3GIK
6
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
83
PsiBlast_CBE
79.81
34%
-78
- C3 -
3KHH
8
DPO4_SULSO
B:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
KAKY
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
13
PsiBlast_PDB
79.69
34%
-77
- C3 -
2W9C
6
DPO4_SULSO
A:
[9-341]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
IG
E
A
------------------
K
-
A
R
Y
----
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
96
PsiBlast_CBE
79.60
34%
-79
- C3 -
4TQS
6
?
B:
[9-341]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
64
PsiBlast_CBE
78.83
34%
-80
- C3 -
3RBE
6
DPO4_SULSO
B:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
KAKY
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
73
PsiBlast_CBE
78.61
34%
-77
- C3 -
3RB0
6
DPO4_SULSO
B:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
CVF
S
G
---
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
KAKY
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
62
PsiBlast_CBE
77.09
34%
-78
- C3 -
2RDI
1
DPO4_SULSO
A:
[3-335]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
---------
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
--------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
---
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
----
M
------------------
I
-
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
-
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
-
R
N
S
R
---
N
L
E
E
I
K
P
Y
L
F
-
R
A
I
E
E
S
Y
Y
K
L
D
K
--
R
------
I
P
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
V
S
R
G
R
T
F
P
H
-----
G
I
--
S
K
E
---
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
------
E
---
D
E
R
K
----
I
R
R
I
G
V
-------------------
105
Fugue
70.05
40%
-94
- C3 -
1JX4
5
DPO4_SULSO
A:
[2-204]
---------------------------------------------------------------------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
---
C
V
FSG
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
-
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
-D-------------------------------------------------
Y
R
---------------
E
--------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
-------
L
G
I
N
K
L
V
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------