@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1714: (2016-03-28 )
MRKRARIIYNPTSGKELFKRELPDALIKLEKAGYETSAYATEKIGDATLEAERAMHENYDVLIAAGGDGTLNEVVNGIAEKPNRPKLGVIPMGTVNDFGRALHIPNDIMGALDVIIEGHSTKVDIGKMNNRYFINLAAGGQLTQVSYETPSKLKSIVGPFAYYIKGFEMLPQMKAVDLRIEYDGNVFQGEALLFFLGLTNSMAGFEKLVPDAKLDDGYFTLIIVEKSNLAELGHIMTLASRGEHTKHPKVIYEKAKAINISSFTDLQLNVDGEYGGKLPANFLNLERHIDVFAPNDIVNEELINNDHVDDNLIEE
Atome Classification :
(20 SA)
-------.........10....----....20....-....30........40........50........60........70.......--.80.--.-----...-----...90........100..---------.....110.......120.......------130-........140.......150.......160.......170.......180.--------------------------.....-.-190...-...--.200-----.------........210.......220.....-..230.......240.....--..250.--......260---..-.....270.....----..280.......290........300.......310...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------MR
K
R
A
R
I
I
YNPT
S
G
K
----
E
L
F
K
R
EL
P
D
A
-
L
I
K
L
E
KAGYETSA
Y
A
TEKIG
D
A
T
L
E
A
E
R
A
MHENY
D
V
L
I
A
AGGDG
T
L
N
E
V
V
N
G
I
--AEKP--N-----RPK-----L
G
V
I
PMG
T
V
N
DFGRALHI---------
P
N
D
I
M
G
A
L
D
V
I
IEGHS
T
K
V
D
I
GKMN------
N
-
R
-
Y
F
I
N
LAAG
G
Q
L
T
Q
V
SYE
T
P
S
K
L
K
S
I
V
G
P
F
A
Y
Y
I
K
G
F
E
MLPQ
M
K
A
V
D
L
R
I
E
YD--------------------------GNVFQ-G-
E
A
L
L
F
F
-LGL--TN-------S------M
A
G
F
E
K
LVPDAKLDDG
Y
F
T
L
I
I
V
EKS-
N
L
A
E
L
G
H
I
M
T
L
ASRGEHTKH--
P
K
V
I
Y
E
--KAK
A
I
NI
S
S
---
F
T
-
D
L
Q
L
N
VDGEYGGK----L
P
A
N
F
L
N
L
E
R
H
I
D
-
V
FAPNDIV
N
E
E
LINNDHVDDNLIEE
20
HHSearch
97.39
100%
-108
- C4 -
2QV7
2
DAGK_STAAR
A:
[23-334]
-------
M
R
K
R
A
R
I
I
Y
N
P
T
S
G
K
----
E
Q
F
K
R
E
L
P
D
A
-
L
I
K
L
E
K
A
G
Y
E
T
S
A
Y
A
T
E
K
I
G
D
A
T
L
E
A
E
R
A
M
H
E
N
Y
D
V
L
I
A
A
G
G
D
G
T
L
N
E
V
V
N
G
I
--
A
E
K
P
--
N
-----
R
P
K
-----
L
G
V
I
P
M
G
T
V
N
D
F
G
R
A
L
H
I
---------
P
N
D
I
M
G
A
L
D
V
I
I
E
G
H
S
T
K
V
D
I
G
K
M
N
------
N
-
R
-
Y
F
I
N
L
A
A
G
G
Q
L
T
Q
-------------
G
P
F
A
Y
Y
I
K
G
F
E
M
L
P
Q
M
K
A
V
D
L
R
I
E
Y
D
--------------------------
G
N
V
F
Q
-
G
-
E
A
L
L
F
F
-
L
G
L
--
T
N
-------
S
------
M
A
G
F
E
K
L
V
P
D
A
K
L
D
D
G
Y
F
T
L
I
I
V
E
K
S
-
N
L
A
E
L
G
H
I
M
T
L
A
S
R
G
E
H
T
K
H
--
P
K
V
I
Y
E
--
K
A
K
A
I
N
I
S
S
---
F
T
-
D
L
Q
L
N
V
D
G
E
Y
G
G
K
----
L
P
A
N
F
L
N
L
E
R
H
I
D
-
V
F
A
P
N
D
I
V
N
E
E
L
I
N
N
D
H
V
D
D
N
L
---
1
PsiBlast_PDB
96.90
97%
-108
- C4 -
2QV7
2
DAGK_STAAR
A:
[24-334]
--------
R
K
R
A
R
I
I
Y
N
P
T
S
G
K
----
E
Q
F
K
R
E
L
P
D
A
-
L
I
K
L
E
K
A
G
Y
E
T
S
A
Y
A
T
E
K
I
G
D
A
T
L
E
A
E
R
A
M
H
E
N
Y
D
V
L
I
A
A
G
G
D
G
T
L
N
E
V
V
N
G
I
--
A
E
K
P
--
N
-----
R
P
K
-----
L
G
V
I
P
M
G
T
V
N
D
F
G
R
A
L
H
I
---------
P
N
D
I
M
G
A
L
D
V
I
I
E
G
H
S
T
K
V
D
I
G
K
M
N
------
N
-
R
-
Y
F
I
N
L
A
A
G
G
Q
L
T
Q
-------------
G
P
F
A
Y
Y
I
K
G
F
E
M
L
P
Q
M
K
A
V
D
L
R
I
E
Y
D
--------------------------
G
N
V
F
Q
-
G
-
E
A
L
L
F
F
-
L
G
L
--
T
N
-------
S
------
M
A
G
F
E
K
L
V
P
D
A
K
L
D
D
G
Y
F
T
L
I
I
V
E
K
S
-
N
L
A
E
L
G
H
I
M
T
L
A
S
R
G
E
H
T
K
H
--
P
K
V
I
Y
E
--
K
A
K
A
I
N
I
S
S
---
F
T
-
D
L
Q
L
N
V
D
G
E
Y
G
G
K
----
L
P
A
N
F
L
N
L
E
R
H
I
D
-
V
F
A
P
N
D
I
V
N
E
E
L
I
N
N
D
H
V
D
D
N
L
---
41
Fugue
70.66
26%
-95
- C4 -
2BON
1
YEGS_ECOLI
A:
[30-326]
---------
P
A
S
L
L
I
L
N
G
K
S
T
D
-------
N
L
P
L
R
E
A
-
I
M
L
L
R
E
E
G
M
T
I
H
V
R
V
T
W
E
K
G
D
A
A
R
Y
V
E
E
A
R
K
F
G
V
A
T
V
I
A
G
G
G
D
G
T
I
N
E
V
S
T
A
L
--
I
Q
C
E
--
G
-----
D
D
I
P
A
---
L
G
I
L
P
L
G
T
A
N
D
F
A
T
S
V
G
I
---------
P
E
A
L
D
K
A
L
K
L
A
I
A
G
D
A
I
A
I
D
M
A
Q
V
N
------
K
Q
T
-
C
F
I
N
M
A
T
G
G
F
G
T
R
I
A
L
----------
G
S
V
S
Y
I
I
H
G
L
M
R
M
D
T
L
Q
P
D
R
C
E
I
R
G
E
--------------------------
N
F
H
W
Q
-
G
-
D
A
L
V
I
G
-
I
G
N
--
G
R
-------
Q
------
A
G
G
G
Q
Q
L
C
P
N
A
L
I
N
D
G
L
L
Q
L
R
I
F
T
G
D
-
E
I
L
P
A
L
V
S
T
L
K
----
S
D
E
D
N
--
P
N
I
I
E
G
--
A
S
S
W
F
D
I
Q
A
---
P
H
-
D
I
T
F
N
L
D
G
E
P
L
S
G
----
Q
N
F
H
I
E
I
L
P
A
A
L
R
-
C
R
L
P
P
D
C
---
P
L
L
R
S
T
---------
22
HHSearch
68.44
28%
-91
- C4 -
2BON
1
YEGS_ECOLI
A:
[30-324]
---------
P
A
S
L
L
I
L
N
G
K
S
T
D
----
N
L
P
---
L
R
E
A
-
I
M
L
L
R
E
E
G
M
T
I
H
V
R
V
T
W
E
K
G
D
A
A
R
Y
V
E
E
A
R
K
F
G
V
A
T
V
I
A
G
G
G
D
G
T
I
N
E
V
S
T
A
L
--
I
Q
C
E
G
D
D
-----
I
P
A
-----
L
G
I
L
P
L
G
T
A
N
D
F
A
T
S
V
G
I
---------
P
E
A
L
D
K
A
L
K
L
A
I
A
G
D
A
I
A
I
D
M
A
Q
V
N
------
K
Q
T
-
C
F
I
N
M
A
T
G
G
F
G
T
R
I
----------
A
L
G
S
V
S
Y
I
I
H
G
L
M
R
M
D
T
L
Q
P
D
R
C
E
I
R
G
E
--------------------------
N
F
H
W
Q
-
G
-
D
A
L
V
I
G
-
I
G
N
--
G
R
-------
Q
------
A
G
G
G
Q
Q
L
C
P
N
A
L
I
N
D
G
L
L
Q
L
R
I
F
T
G
D
-
E
I
L
P
A
---
L
V
S
T
L
K
S
-
D
E
D
N
--
P
N
I
I
E
G
--
A
S
S
W
F
D
I
Q
A
---
P
H
-
D
I
T
F
N
L
D
G
E
P
L
S
G
----
Q
N
F
H
I
E
I
L
P
A
A
L
R
-
C
R
L
P
P
D
C
P
L
L
R
--------------
4
PsiBlast_PDB
68.25
28%
-87
- C4 -
3T5P
1
?
A:
[13-296]
---------
E
K
V
L
L
I
V
N
P
K
A
G
Q
----
G
D
L
H
T
N
L
T
K
I
-
V
P
P
L
A
A
A
F
P
D
L
H
I
L
H
T
K
E
Q
G
D
A
T
K
Y
C
Q
E
-
F
A
S
K
V
D
L
I
I
V
F
G
G
D
G
T
V
F
E
C
T
N
G
L
--
A
P
L
E
--
I
-----
R
P
T
-----
L
A
I
I
P
G
G
T
C
N
D
F
S
R
T
L
G
V
---------
P
Q
N
I
A
E
A
A
K
L
I
T
K
E
H
V
K
P
V
D
V
A
K
A
N
------
G
-
Q
-
H
F
L
N
F
W
G
I
G
L
V
-----------
K
A
K
L
G
K
I
G
Y
Y
L
S
T
I
R
T
V
K
N
A
E
T
F
P
V
K
I
T
Y
D
--------------------------
G
Q
V
Y
E
-
D
-
E
A
V
L
V
M
-
V
G
N
--
G
E
-------
Y
------
L
G
G
I
P
S
F
I
P
N
V
K
C
D
D
G
T
L
D
I
F
V
V
K
S
T
-
G
I
Q
A
F
K
D
Y
I
G
-
K
K
L
F
E
D
S
N
E
--
N
D
I
F
H
V
--
K
A
K
S
I
H
I
E
T
---
E
E
-
E
K
E
V
D
T
D
G
E
S
S
L
H
----
T
P
C
Q
I
E
L
L
Q
G
H
----------------------------
3
PsiBlast_PDB
66.76
28%
-89
- C4 -
4WRR
1
?
A:
[7-290]
---------
E
K
V
L
L
I
V
N
P
K
A
G
Q
----
G
D
L
H
T
N
L
T
K
I
-
V
P
P
L
A
A
A
F
P
D
L
H
I
L
H
T
K
E
Q
G
D
A
T
K
Y
C
Q
E
-
F
A
S
K
V
D
L
I
I
V
F
G
G
D
G
T
V
F
E
C
T
N
G
L
--
A
P
L
E
--
I
-----
R
P
T
-----
L
A
I
I
P
G
G
T
C
N
D
F
S
R
T
L
G
V
---------
P
Q
N
I
A
E
A
A
K
L
I
T
K
E
H
V
K
P
V
D
V
A
K
A
N
------
G
-
Q
-
H
F
L
N
F
W
G
I
G
L
V
---
S
N
N
I
D
A
E
E
K
A
K
L
G
K
I
G
Y
Y
L
S
T
I
R
T
V
K
N
A
E
T
F
P
V
K
I
T
Y
D
--------------------------
G
Q
V
Y
E
-
D
-
E
A
V
L
V
M
-
V
G
N
--
G
E
-------
Y
------
L
G
G
I
P
S
F
I
P
N
V
K
C
D
D
G
T
L
D
I
F
V
V
K
S
T
-
G
I
Q
A
F
K
D
Y
I
G
-
K
K
L
F
E
D
S
----
N
D
I
F
H
V
--
K
A
K
S
I
H
I
E
T
---
E
E
-
E
K
E
V
D
T
D
G
E
S
S
L
H
----
T
P
C
Q
I
E
L
L
Q
G
H
----------------------------
6
PsiBlast_PDB
64.39
31%
-88
- C4 -
2BON
1
YEGS_ECOLI
A:
[37-296]
-------------------
N
G
K
----
S
T
D
N
L
P
L
R
E
A
-
I
M
L
L
R
E
E
G
M
T
I
H
V
R
V
T
W
E
K
G
D
A
A
R
Y
V
E
E
A
R
K
F
G
V
A
T
V
I
A
G
G
G
D
G
T
I
N
E
V
S
T
A
L
I
Q
C
E
G
D
--
D
-----
I
P
A
-----
L
G
I
L
P
L
G
T
A
N
D
F
A
T
S
V
G
I
---------
P
E
A
L
D
K
A
L
K
L
A
I
A
G
D
A
I
A
I
D
M
A
Q
V
N
------
K
-
Q
T
C
F
I
N
M
A
T
G
G
F
G
T
R
I
----------
A
L
G
S
V
S
Y
I
I
H
G
L
M
R
M
D
T
L
Q
P
D
R
C
E
I
R
G
E
--------------------------
N
F
H
W
Q
-
G
-
D
A
L
V
I
G
-
I
G
N
--
G
R
-------
Q
------
A
G
G
G
Q
Q
L
C
P
N
A
L
I
N
D
G
L
L
Q
L
R
I
F
T
G
D
-
E
I
L
P
-
A
L
V
S
T
L
K
S
---
D
E
D
N
--
P
N
I
I
E
G
--
A
S
S
W
F
D
I
Q
A
---
P
H
-
D
I
T
F
N
L
D
G
E
-----------------------------------------------
19
PsiBlast_CBE
63.28
31%
-91
- C4 -
2BON
1
YEGS_ECOLI
B:
[37-296]
-------------------
N
G
K
----
S
T
D
N
L
P
L
R
E
A
-
I
M
L
L
R
E
E
G
M
T
I
H
V
R
V
T
W
E
K
G
D
A
A
R
Y
V
E
E
A
R
K
F
G
V
A
T
V
I
A
G
G
G
D
G
T
I
N
E
V
S
T
A
L
I
Q
C
E
G
D
--
D
-----
I
P
A
-----
L
G
I
L
P
L
G
T
A
N
D
F
A
T
S
V
G
I
---------
P
E
A
L
D
K
A
L
K
L
A
I
A
G
D
A
I
A
I
D
M
A
Q
V
N
------
K
-
Q
T
C
F
I
N
M
A
T
G
G
F
G
T
R
I
--------------
V
S
Y
I
I
H
G
L
M
R
M
D
T
L
Q
P
D
R
C
E
I
R
G
E
--------------------------
N
F
H
W
Q
-
G
-
D
A
L
V
I
G
-
I
G
N
--
G
R
-------
Q
------
A
G
G
G
Q
Q
L
C
P
N
A
L
I
N
D
G
L
L
Q
L
R
I
F
T
-------------------------
P
N
I
I
E
G
--
A
S
S
W
F
D
I
Q
A
---
P
H
-
D
I
T
F
N
L
D
G
E
-----------------------------------------------
8
PsiBlast_PDB
61.71
29%
-87
- C4 -
2P1R
4
YEGS_SALTY
A:
[12-271]
-------------------
N
G
K
----
S
A
D
N
Q
P
L
R
E
A
-
I
T
L
L
R
D
E
G
I
Q
I
H
V
R
V
T
W
E
K
G
D
A
Q
R
Y
V
D
E
A
R
R
L
G
V
E
T
V
I
A
G
G
G
D
G
T
I
N
E
V
S
T
A
L
--
I
Q
I
R
--
D
GV---
A
P
A
-----
L
G
L
L
P
L
G
T
A
N
D
F
A
T
S
A
G
I
---------
P
E
A
L
D
K
A
L
K
L
A
I
A
G
N
A
M
E
I
D
M
A
M
V
N
------
D
-
K
T
C
F
I
N
M
A
T
G
G
F
G
T
R
I
T
T
---------
L
G
G
V
S
Y
L
I
H
G
L
M
R
M
D
T
L
T
P
D
R
C
E
I
R
G
E
--------------------------
N
F
H
W
Q
-
G
-
D
A
L
V
I
G
-
I
G
N
--
G
R
-------
Q
------
A
G
G
G
Q
Q
L
C
P
T
A
L
I
N
D
G
L
L
Q
L
R
I
F
T
G
E
-
E
L
L
P
----
A
L
F
S
T
L
T
Q
S
D
D
N
--
P
N
I
I
D
G
--
A
S
A
W
F
D
I
H
A
---
P
H
-
E
I
T
F
N
L
D
G
E
-----------------------------------------------
7
PsiBlast_PDB
60.39
31%
-77
- C4 -
2JGR
1
YEGS_ECOLI
A:
[12-271]
-------------------
N
G
K
----
S
T
D
N
L
P
L
R
E
A
-
I
M
L
L
R
E
E
G
M
T
I
H
V
R
V
T
W
E
K
G
D
A
A
R
Y
V
E
E
A
R
K
F
G
V
A
T
V
I
A
G
G
G
D
G
T
I
N
E
V
S
T
A
L
I
Q
C
E
G
D
--
D
-----
I
P
A
-----
L
G
I
L
P
L
G
T
A
N
D
F
A
T
S
V
G
I
---------
P
E
A
L
D
K
A
L
K
L
A
I
A
G
D
A
I
A
I
D
M
A
Q
V
N
------
K
-
Q
T
C
F
I
N
M
A
T
G
G
F
G
T
--------------------
I
H
G
L
M
R
M
D
T
L
Q
P
D
R
C
E
I
R
G
E
--------------------------
N
F
H
W
Q
-
G
-
D
A
L
V
I
G
-
I
G
N
--
G
R
-------
Q
------
A
G
G
G
Q
Q
L
C
P
N
A
L
I
N
D
G
L
L
Q
L
R
I
F
T
G
--------------------
D
N
--
P
N
I
I
E
G
--
A
S
S
W
F
D
I
Q
A
---
P
H
-
D
I
T
F
N
L
D
G
E
-----------------------------------------------
43
Fugue
57.12
18%
-78
- C4 -
3VZD
2
SPHK1_HUMAN
A:
[3-361]
MGS
G
V
L
P
R
P
C
R
V
L
V
L
L
N
P
R
G
G
K
----
G
K
A
L
Q
L
F
R
S
H
V
Q
P
L
L
A
E
A
E
I
S
F
T
L
M
L
T
E
R
R
N
H
A
R
E
L
V
R
S
E
E
L
G
R
W
D
A
L
V
V
M
S
G
D
G
L
M
H
E
V
V
N
G
L
--
M
E
R
P
--
D
-----
W
E
T
A
I
Q
K
P
L
C
S
L
P
A
G
S
G
N
A
L
A
A
S
L
N
H
Y
A
GYEQVTN
E
D
L
L
T
N
C
T
L
L
L
C
R
R
L
L
S
P
M
N
L
L
S
L
H
T
ASG
L
R
L
-
F
-
S
V
L
S
L
A
W
G
---
F
I
A
D
V
D
L
E
S
E
K
Y
R
R
L
G
E
M
R
F
T
L
G
T
F
L
R
L
A
A
L
R
T
Y
R
G
R
L
A
Y
L
P
VGRVGSQGPVDAHLVPLEEPVPSH
W
T
V
V
P
D
-
E
-
D
F
V
L
V
L
-
A
L
L
--
H
S
-------
H
------
L
G
S
E
M
F
A
A
P
M
G
R
C
A
A
G
V
M
H
L
F
Y
V
R
A
G
V
S
R
A
M
L
L
R
L
F
L
A
M
E
K
G
R
H
M
E
Y
EC
P
Y
L
V
Y
V
--
P
V
V
A
F
R
L
E
P
---
K
D
G
K
G
V
F
A
V
D
G
E
L
M
V
S
----
E
A
V
Q
G
Q
V
H
P
N
Y
F
W
-
M
V
S
G
---------------------
21
HHSearch
56.72
27%
-48
* C4 *
3S40
-
?
A:
[6-300]
--------
F
E
K
V
L
L
I
V
N
P
K
A
G
Q
----
G
D
L
H
T
N
L
T
K
I
-
V
P
P
L
A
A
A
F
P
D
L
H
I
L
H
T
K
E
Q
G
D
A
T
K
Y
C
Q
E
F
A
-
S
K
V
D
L
I
I
V
F
G
G
D
G
T
V
F
E
C
T
N
G
L
--
A
P
L
E
--
I
-----
R
P
T
-----
L
A
I
I
P
G
G
T
C
N
D
F
S
R
T
L
G
V
---------
P
Q
N
I
A
E
A
A
K
L
I
T
K
E
H
V
K
P
V
D
V
A
K
A
N
------
G
-
Q
-
H
F
L
N
F
W
G
I
G
------------------
K
I
G
Y
Y
L
S
T
I
------
E
T
F
P
V
K
I
T
Y
D
--------------------------
G
Q
V
Y
E
-
D
-
E
A
V
L
V
M
-
V
G
N
--
G
E
-------
Y
------
L
G
G
I
P
S
F
I
P
N
V
K
C
D
D
G
T
L
D
I
F
V
V
K
S
T
-
G
I
Q
A
F
K
D
Y
I
G
K
K
L
F
E
D
S
-
N
E
--
N
D
I
F
H
V
--
K
A
K
S
I
H
I
E
T
---
E
E
-
E
K
E
V
D
T
D
--
S
S
L
H
----
T
P
C
Q
I
E
L
L
Q
G
H
F
T
-
M
I
Y
N
P
A
V
V
-----------------
40
Fugue
56.01
27%
-42
- C4 -
3S40
-
?
A:
[3-300]
-----KT
K
F
E
K
V
L
L
I
V
N
P
K
A
G
Q
----
G
D
L
H
T
N
L
T
K
I
-
V
P
P
L
A
A
A
F
P
D
L
H
I
L
H
T
K
E
Q
G
D
A
T
K
Y
C
Q
E
F
A
-
S
K
V
D
L
I
I
V
F
G
G
D
G
T
V
F
E
C
T
N
G
L
--
A
P
L
E
--
I
-----
R
P
T
-----
L
A
I
I
P
G
G
T
C
N
D
F
S
R
T
L
G
V
---------
P
Q
N
I
A
E
A
A
K
L
I
T
K
E
H
V
K
P
V
D
V
A
K
A
N
------
G
-
Q
-
H
F
L
N
------------------
F
W
G
I
G
K
I
G
Y
Y
L
S
T
------
I
E
T
F
P
V
K
I
T
Y
D
--------------------------
G
Q
V
Y
E
-
D
-
E
-
A
V
L
V
M
V
G
N
--
G
E
-------
Y
------
L
G
G
I
P
S
F
I
P
N
V
K
C
D
D
G
T
L
D
I
F
V
V
K
S
T
-
G
I
Q
A
F
K
D
Y
I
G
-
K
K
L
F
E
D
S
N
E
--
N
D
I
F
H
V
--
K
A
K
S
I
H
I
E
T
---
E
E
-
E
K
E
V
D
T
D
S
S
L
H
T
------
P
C
Q
I
E
L
L
Q
G
H
F
T
M
I
Y
N
P
A
V
V
------------------
5
PsiBlast_PDB
55.17
28%
-50
- C4 -
3S40
-
?
A:
[7-290]
---------
E
K
V
L
L
I
V
N
P
K
A
G
Q
----
G
D
L
H
T
N
L
T
K
I
-
V
P
P
L
A
A
A
F
P
D
L
H
I
L
H
T
K
E
Q
G
D
A
T
K
Y
C
Q
E
-
F
A
S
K
V
D
L
I
I
V
F
G
G
D
G
T
V
F
E
C
T
N
G
L
--
A
P
L
E
--
I
-----
R
P
T
-----
L
A
I
I
P
G
G
T
C
N
D
F
S
R
T
L
G
V
---------
P
Q
N
I
A
E
A
A
K
L
I
T
K
E
H
V
K
P
V
D
V
A
K
A
N
------
G
-
Q
-
H
F
L
N
F
W
G
I
G
------------------
K
I
G
Y
Y
L
S
T
I
------
E
T
F
P
V
K
I
T
Y
D
--------------------------
G
Q
V
Y
E
-
D
-
E
A
V
L
V
M
-
V
G
N
--
G
E
-------
Y
------
L
G
G
I
P
S
F
I
P
N
V
K
C
D
D
G
T
L
D
I
F
V
V
K
S
T
-
G
I
Q
A
F
K
D
Y
I
G
-
K
K
L
F
E
D
S
N
E
--
N
D
I
F
H
V
--
K
A
K
S
I
H
I
E
T
---
E
E
-
E
K
E
V
D
T
D
--
S
S
L
H
----
T
P
C
Q
I
E
L
L
Q
G
H
----------------------------
2
PsiBlast_PDB
48.05
33%
-8
- C4 -
4WER
2
?
A:
[5-297]
---------
K
K
A
V
L
I
V
N
P
S
S
G
G
----
E
K
A
K
E
F
E
T
L
A
-
E
E
K
L
K
Q
L
F
D
E
V
V
V
K
Q
T
E
K
G
G
D
A
E
Q
F
A
R
E
A
A
E
S
H
F
D
S
V
F
V
M
G
G
D
G
T
V
N
E
G
I
S
G
L
--
A
E
Q
A
--
Y
-----
R
P
K
-----
F
G
F
F
P
L
G
T
V
N
D
L
A
R
A
L
N
L
---------
P
M
D
P
E
E
A
I
Q
Q
L
D
L
E
K
T
S
A
L
D
V
G
K
I
N
------
D
-
D
-
Y
F
M
N
V
V
A
I
G
T
I
-------------
K
L
G
K
L
A
Y
F
I
S
G
A
K
H
L
A
N
A
Q
T
Y
P
F
H
L
S
L
D
--------------------------
Q
K
E
Q
T
-
I
-
E
S
S
T
V
L
-
V
G
L
--
T
N
-------
S
------
I
G
G
F
E
T
L
L
P
E
A
Q
V
D
D
G
K
L
H
L
V
Y
L
K
D
Q
-
S
L
W
D
A
V
K
A
V
P
D
L
L
K
G
V
D
Q
S
T
--
D
N
L
V
Y
L
T
F
K
E
G
T
I
S
L
E
N
---
Q
E
-
E
L
T
T
N
V
D
G
D
E
G
A
A
----
L
P
I
T
L
K
I
L
P
K
H
L
T
-
V
Y
C
----------------------
24
HHSearch
43.50
11%
-72
- C4 -
1U0T
-
NADK_MYCTU
A:
[5-287]
---------
R
S
V
L
L
V
V
H
T
G
R
D
E
----
A
T
--
E
T
A
R
R
V
-
E
K
V
L
G
D
N
K
I
A
L
R
V
L
S
------------------
C
E
L
V
L
V
L
G
G
D
G
T
F
L
R
A
A
E
L
A
--
R
N
----
A
-----
S
I
P
-----
V
L
G
V
N
L
G
R
I
G
F
L
A
-
E
A
E
----------
A
E
A
I
D
A
V
L
E
H
V
V
A
Q
D
Y
R
V
E
D
R
L
T
L
D
------
V
-
V
-
V
R
Q
G
G
-
R
I
V
N
R
G
W
A
L
N
E
V
S
----------------
L
E
K
G
P
R
L
G
V
L
G
V
V
V
E
I
D
--------------------------
G
R
P
V
S
-
A
F
G
C
D
G
V
L
-
V
S
T
--
P
T
-------
G
STA
Y
A
F
S
A
G
G
----
P
V
L
W
P
D
L
E
A
I
L
V
V
P
N
N
A
H
-
A
L
F
----------------
G
--
R
P
M
V
T
S
--
P
E
A
T
I
A
I
E
I
EAD
G
H
-
D
A
L
V
F
C
D
G
R
R
E
M
L
I
P
AG
S
R
L
E
V
T
R
C
V
T
S
V
K
-
W
A
R
L
D
S
A
------------------
25
HHSearch
42.83
17%
-67
- C4 -
1Z0S
3
NADK_ARCFU
A:
[30-266]
---------
M
R
A
A
V
V
Y
K
T
D
G
-----------
H
V
K
R
I
-
E
E
A
L
K
R
L
E
V
E
V
E
L
F
N
Q
P
---------
S
-
E
E
L
E
N
F
D
F
I
V
S
V
G
G
D
G
T
I
L
R
I
L
Q
K
L
--
K
-----
R
-----
C
P
P
-----
I
F
G
I
N
T
G
R
V
G
L
L
T
-
H
A
S
----------
P
E
N
F
E
V
E
L
K
K
A
V
E
-
K
F
E
------
V
E
--------
R
-
F
P
R
V
S
C
S
A
M
P
D
V
L
A
L
N
E
I
A
V
-
L
S
R
K
---------------
P
A
K
M
I
D
V
A
L
R
V
D
--------------------------
G
V
E
V
D
-
R
I
R
C
D
G
F
I
-
V
A
T
--
Q
I
GSTG
Y
A
F
S
------
A
G
G
P
-
V
----
V
E
P
Y
L
E
C
F
I
L
I
P
I
A
P
F
-
R
F
G
----------------
W
--
K
P
Y
V
V
S
--
M
E
R
K
I
E
V
I
A
----
E
-
K
A
I
V
V
A
D
G
Q
K
S
V
D
F
D
--
G
E
I
T
I
E
K
S
E
F
P
A
V
-
F
F
K
N
E
K
R
------------------
10
PsiBlast_PDB
42.33
26%
-73
- C4 -
3VZD
-
SPHK1_HUMAN
A:
[13-127]
----------
R
V
L
V
L
L
N
P
R
G
G
K
GK
A
L
Q
L
F
R
S
H
V
Q
P
L
-
L
A
E
A
E
---
I
S
F
T
L
M
L
T
E
R
R
N
H
A
R
E
L
V
R
S
E
E
L
G
R
W
D
A
L
V
V
M
S
G
D
G
L
M
H
E
V
V
N
G
L
--
M
E
R
P
--
D
W
E
T
A
I
Q
K
P
-----
L
C
S
L
P
A
G
S
G
N
A
L
A
A
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
42.32
15%
-66
- C4 -
1YT5
6
NADK_THEMA
A:
[1-242]
---------
M
K
I
A
I
L
Y
R
E
E
R
E
K
---------
E
G
E
F
L
-
K
E
K
I
S
K
-
E
H
E
V
--
I
E
F
G
------
E
A
N
A
P
-
G
R
V
T
A
D
L
I
V
V
V
G
G
D
G
T
V
L
K
A
A
K
K
A
--
A
-----
D
-----
G
T
P
-----
M
V
G
F
K
A
G
R
L
G
F
L
T
S
-
Y
T
----------
L
D
E
I
D
R
F
L
E
D
L
R
N
W
N
F
R
E
E
------------
T
-
R
-
W
F
I
Q
I
E
S
E
L
G
N
H
L
A
L
N
D
V
T
L
E
R
D
----------------
L
S
G
K
M
V
E
I
E
V
E
V
E
--------------------------
H
H
S
S
M
W
F
-
F
A
D
G
V
V
-
I
S
T
PT
G
S
-------
T
A
Y
S
L
--
S
I
G
G
----
P
I
I
F
P
E
C
E
V
L
E
I
S
P
I
A
P
Q
-
F
F
L
-----------
T
-------
R
S
V
V
I
P
--
S
N
F
K
V
V
V
E
S
---
Q
R
-
D
I
N
M
L
V
D
G
V
L
T
G
K
T---
K
R
I
E
V
K
K
S
R
R
Y
V
R
-
I
L
R
P
P
E
Y
D
-----------------
11
PsiBlast_PDB
41.54
26%
-72
- C4 -
3VZC
-
SPHK1_HUMAN
A:
[13-129]
----------
R
V
L
V
L
L
N
P
R
G
G
K
GK
A
L
Q
L
F
R
S
H
V
Q
P
L
-
L
A
E
A
E
---
I
S
F
T
L
M
L
T
E
R
R
N
H
A
R
E
L
V
R
S
E
E
L
G
R
W
D
A
L
V
V
M
S
G
D
G
L
M
H
E
V
V
N
G
L
--
M
E
R
P
--
D
WETAI
Q
K
P
-----
L
C
S
L
P
A
G
S
G
N
A
L
A
A
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------