@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1846: (2016-03-29 )
MTEWTREERYQRIEDVDTEYFKTLKQQVDQSKFRQQFHIQPETGLLNDPNGLIFYKGKYYVSHQWFPLGAVHGLKYWYNYTSDDLINFKPEGPILNPDTKYDSHGVYSGSAFEYNGHLYYMYTGNHRDNHWQRHASQMIARLKEDGSVEKFPKPVISQQPEGYTSHFRDPKVFKYGEKYYAIIGAQNNDQQGRLLLYNTEDIINWHYLGEINTELDDFGYMWECPDYFNLDNQDVILICPQGIEPKGNQFKNIYQSGYILGKFDIEKLTYEHENFVELDNGFDFYAPQTFLDEKGRRVLIGWMGLPEIEYPTDNEGWAHCLTIPRVLNVENGQLKQRPYPALEKLRHNKETALGYANKFTRKLHPYEGKQYELIIDILDNDATEVYFELRTSKTSSTLIAYNKRENKITLDRSDSGLLPTNVEGTTRSTILDTPLKQLQIFVDTSSIEIFCNDGERVLTSRIFPTEDALGIKTSTESGQVYLQFTKYDLKDEHK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100....--...110.-----------..-.----------....120..----.....130--.........140...-..--.-.150...-...---..---160--......--..170...--....180.......190.......200.......210....----....220-.........230-----...------.....240.......250.......260..-.....270-.---.......280.......290---.---......300..--..--..--.310.......320.......-330--.-.---.......340....-----...350....--...360----.......370.......380.........390.-...-...400.......410.......420-........430---.---.---.....----..440.......450.......460.......470.......480-.......490..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTE
W
T
R
E
E
R
Y
Q
R
I
E
DV
D
T
E
Y
F
K
T
L
K
Q
Q
V
D
Q
S
K
F
R
Q
Q
FHIQPETGLLNDPN
G
L
I
F
YK
G
K
Y
Y
V
S
H
QWFP
L
G
A
V
HG
L
K
Y
W
Y
NYTSD
D
L
I
NFKPEGPILNPDTKYDSHGV--YSG
S
A
-
F
-----------
E
Y-N----------
G
H
L
Y
Y
M
Y
TG----NHR
D
N
H
----
W
Q
R
H
A
S
Q
M
I
A
R
L
KED-GS--V-EKF-PK
P
-
V
IS---QQ---P-E--GYTSHF--RDP
K
V
FKY--G
E
K
Y
Y
A
I
I
GAQNNDQQ
G
R
L
L
L
Y
NTED
I
I
N
W
H
Y
LGEI-NTEL----DDFG
Y
---
M
WECPDYFNLD------NQ
D
------
V
I
L
ICPQGIEPK
G
N
Q
F
K
N
I
Y
QS
G
Y
I
L
G
KF
D
-
I
E
K
L
T
YE--H---E
N
F
V
ELDNGFDFYA
P
Q
T
F
L
D
---E---KG
R
R
V
L
I
GWMG--LP--EI--EYPTDNEG
W
A
H
C
LTI
P
R
V
L
NV-E----N-G---QLKQRP
Y
P
A
L
E
K
L
R-----HNK
E
T
A
L
G
Y
A
--
N
K
F
T
RK----LHPYEG
K
Q
Y
E
L
I
I
D
ILDN--DA
T
E
V
Y
F
E
L
RTSK-TS
S
-
T
L
I
A
Y
NKRE
N
K
I
T
LDRSDSGLLPT-N-VEGTTRS
T
I
-----L---D---T
P
L
K
Q
----
L
Q
I
F
V
DT
S
S
I
E
I
F
CND
G
E
R
V
L
T
SRIFPTEDALGIKTSTES
G
Q
V
Y
L
-
Q
F
TKYDLKDEHK
38
HHSearch
93.74
31%
-70
- C3 -
1W2T
2
BFRA_THEMA
A:
[2-431]
--------------------------------
F
K
P
N
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
--
E
T
H
G
V
--
F
S
G
S
A
-
V
-----------
E
K
-
D
----------
G
K
M
F
L
V
Y
T
Y
----
Y
R
D
P
T
H
N---
K
G
E
K
E
T
Q
C
V
V
M
S
E
N
--
G
L
D
-
F
-
V
K
Y
-
D
G
N
P
V
I
S
---
K
P
---
P
-
E
--
E
G
T
H
A
F
--
R
D
P
K
V
N
R
S
--
N
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
K
Y
E
G
A
I
-
F
E
D
------
E
T
T
K
---
E
I
D
C
P
D
L
V
R
I
G
------
E
K
D
------
I
L
I
Y
S
I
T
S
T
----------
N
S
V
L
F
S
M
G
E
L
K
-
E
G
K
L
N
-
V
------
E
K
R
G
L
L
D
H
G
T
D
F
Y
A
A
Q
T
F
F
G
-------
T
D
R
V
V
V
I
G
W
L
Q
--
S
W
--
L
R
TG
L
Y
P
T
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
-
E
----
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
-----
K
R
K
V
F
E
T
A
K
S
---
G
T
F
-
L
----
L
-
D
V
K
E
N
S
Y
E
I
V
C
E
F
S
G
------
E
I
E
L
R
M
G
N
----
E
S
-
E
E
V
V
I
T
K
S
R
D
E
L
I
V
D
T
T
R
S
G
V
S
------
G
G
E
V
R
K
S
T
-----
V
E
--
D
---
E
A
T
N
R
----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
S
-
I
A
F
S
F
R
I
H
P
E
N
V
Y
N
I
L
S
V
K
S
N
-
Q
---
V
-
K
L
E
V
F
E
L
E
N
I
W
-
21
PsiBlast_CBE
91.64
32%
-61
- C3 -
1UYP
5
BFRA_THEMA
F:
[2-423]
--------------------------------
F
K
P
N
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
--
E
T
H
G
V
--
F
S
G
S
A
-
V
-----------
E
K
-
D
----------
G
K
M
F
L
V
Y
T
Y
----
Y
R
D
P
T
H
----
N
K
G
E
K
E
T
Q
C
V
V
M
S
E
N
-
G
L
DF
V
-
K
Y
D
-
G
N
P
-
V
I
S
---
K
P
---
P
-
E
--
E
G
T
H
A
F
--
R
D
P
K
V
N
R
S
--
N
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
K
Y
E
G
A
I
-
F
E
------
D
E
T
T
K
---
E
I
E
C
P
D
L
V
R
I
G
------
E
K
D
------
I
L
I
Y
----------
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
-
E
G
K
L
N
V
E
--
K
---
R
G
L
--
L
D
H
G
T
D
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
SW
L
R
--
T
G
--
L
Y
P
T
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
-
E
----
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
-----
K
R
K
V
F
E
T
A
K
S
--
G
T
F
-------
L
L
D
V
K
E
N
S
Y
E
I
V
C
E
F
------
S
G
E
I
--
E
L
R
M
G
N
-
E
S
E
-
E
V
V
I
T
K
S
R
-
D
E
L
I
V
D
T
T
R
S
G
V
S
G
G
-
E
-
V
R
---
K
S
T
V
-----
E
---
D
---
E
A
T
N
R
----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
S
-
I
A
F
S
F
R
I
H
P
-
E
N
V
Y
N
I
-
L
S
V
K
S
N
Q
V
K
L
-
E
-----------
24
PsiBlast_CBE
91.59
32%
-63
- C3 -
1UYP
4
BFRA_THEMA
C:
[2-423]
--------------------------------
F
K
P
N
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
--
E
T
H
G
V
--
F
S
G
S
A
-
V
-----------
E
K
-
D
----------
G
K
M
F
L
V
Y
T
Y
----
Y
R
D
P
T
H
----
N
K
G
E
K
E
T
Q
C
V
V
M
S
E
N
-
G
L
DF
V
-
K
Y
D
-
G
N
P
-
V
I
S
---
K
P
---
P
-
E
--
E
G
T
H
A
F
--
R
D
P
K
V
N
R
S
--
N
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
K
Y
E
G
A
I
-
F
E
------
D
E
T
T
K
---
E
I
E
C
P
D
L
V
R
I
G
------
E
K
D
------
I
L
I
Y
----------
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
-
E
G
K
L
N
V
E
--
K
---
R
G
L
--
L
D
H
G
T
D
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
SW
L
R
--
T
G
--
L
Y
P
T
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
-
E
----
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
-----
K
R
K
V
F
E
T
A
K
S
--
G
T
F
-------
L
L
D
V
K
E
N
S
Y
E
I
V
C
E
F
------
S
G
E
I
--
E
L
R
M
G
N
-
E
S
E
-
E
V
V
I
T
K
S
R
-
D
E
L
I
V
D
T
T
R
S
G
V
S
G
G
-
E
-
V
R
---
K
S
T
V
-----
E
---
D
---
E
A
T
N
R
----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
S
-
I
A
F
S
F
R
I
H
P
-
E
N
V
Y
N
I
-
L
S
V
K
S
N
Q
V
K
L
-
E
-----------
30
PsiBlast_CBE
91.35
31%
-66
- C3 -
1W2T
2
BFRA_THEMA
B:
[2-423]
--------------------------------
F
K
P
N
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
--
E
T
H
G
V
--
F
S
G
S
A
-
V
-----------
E
K
-
D
----------
G
K
M
F
L
V
Y
T
Y
----
Y
R
D
P
T
H
----
N
K
G
E
K
E
T
Q
C
V
V
M
S
E
N
-
G
L
DF
V
-
K
Y
D
-
G
N
P
-
V
I
S
---
K
P
---
P
-
E
--
E
G
T
H
A
F
--
R
D
P
K
V
N
R
S
--
N
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
K
Y
E
G
A
I
-
F
E
------
D
E
T
T
K
---
E
I
D
C
P
D
L
V
R
I
G
------
E
K
D
------
I
L
I
Y
----------
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
-
E
G
K
L
N
V
E
--
K
---
R
G
L
--
L
D
H
G
T
D
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
SW
L
R
--
T
G
--
L
Y
P
T
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
-
E
----
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
-----
K
R
K
V
F
E
T
A
K
S
--
G
T
F
-------
L
L
D
V
K
E
N
S
Y
E
I
V
C
E
F
------
S
G
E
I
--
E
L
R
M
G
N
-
E
S
E
-
E
V
V
I
T
K
S
R
D
-
E
L
I
V
D
T
T
R
S
G
V
S
G
G
-
E
-
V
R
---
K
S
T
V
-----
E
---
D
---
E
A
T
N
R
----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
S
-
I
A
F
S
F
R
I
H
P
-
E
N
V
Y
N
I
-
L
S
V
K
S
N
Q
V
K
L
-
E
-----------
35
HHSearch
91.22
24%
-59
* C3 *
3SC7
4
INU2_ASPFI
X:
[24-515]
----------------------------
Q
S
N
D
Y
R
P
S
Y
H
F
T
P
D
Q
Y
W
M
N
E
P
N
G
L
I
K
I
G
S
T
W
H
L
F
F
Q
H
N
P
T
A
N
V
W
G
N
I
C
W
G
H
A
T
S
T
D
L
M
H
W
A
H
K
P
T
A
I
A
D
E
N
---
G
V
E
A
--
F
T
G
T
A
-
Y
-----------
Y
D
P
N
NTSGLGDSAN
P
P
Y
L
A
W
F
T
G
----
Y
T
T
S
-------
S
Q
T
Q
D
Q
R
L
A
F
S
V
D
N
-
G
A
T-
W
-
T
K
F
-
Q
G
N
P
I
I
S
---
T
S
QEA
P
-
H
DI
T
G
G
L
E
S
--
R
D
P
K
V
F
F
H
RQ
S
G
N
W
I
M
V
L
A
H
G
G
---
Q
D
K
L
S
F
W
T
S
A
D
T
I
N
W
T
W
Q
S
D
L
-
K
S
T
S
INGL
S
S
D
I
T
---
G
W
E
V
P
D
M
F
E
L
P
VEGTEE
T
T
W
------
V
V
M
M
T
P
A
E
G
S
P
A
-----
G
G
N
G
V
L
A
I
T
G
S
F
D
-
G
K
S
F
-
T
A
--
D
PVD
A
S
T
M
W
L
D
N
G
R
D
F
D
G
A
L
S
W
V
N
---
V
PAS
D
G
R
R
I
I
A
A
V
M
N
--
S
Y
--
G
S
--
N
P
P
T
--
T
T
W
K
G
M
L
S
F
P
R
T
L
S
L
-
K
----
K
V
G
TQQ
H
F
V
Q
Q
P
I
T
E
L
D
T
I
S
-----
T
S
L
Q
I
L
A
N
Q
T
IT
P
G
Q
T
-
L
----
L
S
S
I
R
G
T
A
L
D
V
R
V
A
F
Y
P
D
--
A
G
S
V
L
S
L
A
V
R
K
G
A
-
S
E
Q
-
T
V
I
K
Y
T
Q
S
D
A
T
L
S
V
D
R
T
E
S
G
D
I
S
Y
D
P
-
A
A
G
G
V
H
T
A
K
-----
L
EED
G
---
T
G
L
V
S
----
I
R
V
L
V
D
T
C
S
V
E
V
F
G
G
Q
G
E
A
V
I
S
D
L
I
F
P
S
D
S
S
D
G
L
A
L
E
V
T
G
G
N
A
V
L
Q
S
V
D
V
R
S
V
S
L
---
4
PsiBlast_PDB
91.18
31%
-63
- C3 -
1W2T
2
BFRA_THEMA
A:
[2-423]
--------------------------------
F
K
P
N
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
--
E
T
H
G
V
--
F
S
G
S
A
-
V
-----------
E
K
-
D
----------
G
K
M
F
L
V
Y
T
Y
----
Y
R
D
P
T
H
----
N
K
G
E
K
E
T
Q
C
V
V
M
S
E
N
-
G
L
D
F
V
-
K
Y
D
-
G
N
P
-
V
I
S
---
K
P
---
P
-
E
--
E
G
T
H
A
F
--
R
D
P
K
V
N
R
S
--
N
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
K
Y
E
G
A
I
-
F
E
------
D
E
T
T
K
---
E
I
D
C
P
D
L
V
R
I
G
------
E
K
D
------
I
L
I
Y
----------
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
-
E
G
K
L
N
V
E
--
K
---
R
G
L
--
L
D
H
G
T
D
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
SW
L
R
--
T
G
--
L
Y
P
T
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
-
E
----
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
-----
K
R
K
V
F
E
T
A
K
S
--
G
T
F
-------
L
L
D
V
K
E
N
S
Y
E
I
V
C
E
F
------
S
G
E
I
--
E
L
R
M
G
N
-
E
S
E
-
E
V
V
I
T
K
S
R
D
-
E
L
I
V
D
T
T
R
S
G
V
S
G
G
-
E
-
V
R
---
K
S
T
V
-----
E
---
D
---
E
A
T
N
R
----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
S
-
I
A
F
S
F
R
I
H
P
-
E
N
V
Y
N
I
-
L
S
V
K
S
N
Q
V
K
L
-
E
-----------
28
PsiBlast_CBE
91.08
31%
-62
- C3 -
1W2T
1
BFRA_THEMA
D:
[2-423]
--------------------------------
F
K
P
N
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
--
E
T
H
G
V
--
F
S
G
S
A
-
V
-----------
E
K
-
D
----------
G
K
M
F
L
V
Y
T
Y
----
Y
R
D
P
T
H
----
N
K
G
E
K
E
T
Q
C
V
V
M
S
E
N
-
G
L
DF
V
-
K
Y
D
-
G
N
P
-
V
I
S
---
K
P
---
P
-
E
--
E
G
T
H
A
F
--
R
D
P
K
V
N
R
S
--
N
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
K
Y
E
G
A
I
-
F
E
------
D
E
T
T
K
---
E
I
D
C
P
D
L
V
R
I
G
------
E
K
D
------
I
L
I
Y
----------
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
-
E
G
K
L
N
V
E
--
K
---
R
G
L
--
L
D
H
G
T
D
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
SW
L
R
--
T
G
--
L
Y
P
T
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
-
E
----
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
-----
K
R
K
V
F
E
T
A
K
S
--
G
T
F
-------
L
L
D
V
K
E
N
S
Y
E
I
V
C
E
F
------
S
G
E
I
--
E
L
R
M
G
N
-
E
S
E
-
E
V
V
I
T
K
S
R
D
-
E
L
I
V
D
T
T
R
S
G
V
S
G
G
-
E
-
V
R
---
K
S
T
V
-----
E
---
D
---
E
A
T
N
R
----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
S
-
I
A
F
S
F
R
I
H
P
-
E
N
V
Y
N
I
-
L
S
V
K
S
N
Q
V
K
L
-
E
-----------
23
PsiBlast_CBE
90.56
32%
-61
- C3 -
1UYP
2
BFRA_THEMA
D:
[2-423]
--------------------------------
F
K
P
N
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
--
E
T
H
G
V
--
F
S
G
S
A
-
V
-----------
E
K
-
D
----------
G
K
M
F
L
V
Y
T
Y
----
Y
R
D
P
T
H
----
N
K
G
E
K
E
T
Q
C
V
V
M
S
E
N
-
G
L
DF
V
-
K
Y
D
-
G
N
P
-
V
I
S
---
K
P
---
P
-
E
--
E
G
T
H
A
F
--
R
D
P
K
V
N
R
S
--
N
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
K
Y
E
G
A
I
-
F
E
------
D
E
T
T
K
---
E
I
E
C
P
D
L
V
R
I
G
------
E
K
D
------
I
L
I
Y
----------
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
-
E
G
K
L
N
V
E
--
K
---
R
G
L
--
L
D
H
G
T
D
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
SW
L
R
--
T
G
--
L
Y
P
T
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
-
E
----
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
-----
K
R
K
V
F
E
T
A
K
S
--
G
T
F
-------
L
L
D
V
K
E
N
S
Y
E
I
V
C
E
F
------
S
G
E
I
--
E
L
R
M
G
N
-
E
S
E
-
E
V
V
I
T
K
S
R
-
D
E
L
I
V
D
T
T
R
S
G
V
S
G
G
-
E
-
V
R
---
K
S
T
V
-----
E
---
D
---
E
A
T
N
R
----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
S
-
I
A
F
S
F
R
I
H
P
-
E
N
V
Y
N
I
-
L
S
V
K
S
N
Q
V
K
L
-
E
-----------
29
PsiBlast_CBE
90.43
31%
-64
- C3 -
1W2T
3
BFRA_THEMA
C:
[2-423]
--------------------------------
F
K
P
N
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
--
E
T
H
G
V
--
F
S
G
S
A
-
V
-----------
E
K
-
D
----------
G
K
M
F
L
V
Y
T
Y
----
Y
R
D
P
T
H
----
N
K
G
E
K
E
T
Q
C
V
V
M
S
E
N
-
G
L
DF
V
-
K
Y
D
-
G
N
P
-
V
I
S
---
K
P
---
P
-
E
--
E
G
T
H
A
F
--
R
D
P
K
V
N
R
S
--
N
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
K
Y
E
G
A
I
-
F
E
------
D
E
T
T
K
---
E
I
D
C
P
D
L
V
R
I
G
------
E
K
D
------
I
L
I
Y
----------
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
-
E
G
K
L
N
V
E
--
K
---
R
G
L
--
L
D
H
G
T
D
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
SW
L
R
--
T
G
--
L
Y
P
T
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
-
E
----
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
-----
K
R
K
V
F
E
T
A
K
S
--
G
T
F
-------
L
L
D
V
K
E
N
S
Y
E
I
V
C
E
F
------
S
G
E
I
--
E
L
R
M
G
N
-
E
S
E
-
E
V
V
I
T
K
S
R
D
-
E
L
I
V
D
T
T
R
S
G
V
S
G
G
-
E
-
V
R
---
K
S
T
V
-----
E
---
D
---
E
A
T
N
R
----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
S
-
I
A
F
S
F
R
I
H
P
-
E
N
V
Y
N
I
-
L
S
V
K
S
N
Q
V
K
L
-
E
-----------
3
PsiBlast_PDB
90.37
32%
-60
- C3 -
1UYP
6
BFRA_THEMA
A:
[2-423]
--------------------------------
F
K
P
N
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
--
E
T
H
G
V
--
F
S
G
S
A
-
V
-----------
E
K
-
D
----------
G
K
M
F
L
V
Y
T
Y
----
Y
R
D
P
T
H
----
N
K
G
E
K
E
T
Q
C
V
V
M
S
E
N
-
G
L
D
F
V
-
K
Y
D
-
G
N
P
-
V
I
S
---
K
P
---
P
-
E
--
E
G
T
H
A
F
--
R
D
P
K
V
N
R
S
--
N
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
K
Y
E
G
A
I
-
F
E
------
D
E
T
T
K
---
E
I
E
C
P
D
L
V
R
I
G
------
E
K
D
------
I
L
I
Y
----------
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
-
E
G
K
L
N
V
E
--
K
---
R
G
L
--
L
D
H
G
T
D
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
SW
L
R
--
T
G
--
L
Y
P
T
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
-
E
----
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
-----
K
R
K
V
F
E
T
A
K
S
--
G
T
F
-------
L
L
D
V
K
E
N
S
Y
E
I
V
C
E
F
------
S
G
E
I
--
E
L
R
M
G
N
-
E
S
E
-
E
V
V
I
T
K
S
R
-
D
E
L
I
V
D
T
T
R
S
G
V
S
G
G
-
E
-
V
R
---
K
S
T
V
-----
E
---
D
---
E
A
T
N
R
----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
S
-
I
A
F
S
F
R
I
H
P
-
E
N
V
Y
N
I
-
L
S
V
K
S
N
Q
V
K
L
-
E
-----------
27
PsiBlast_CBE
90.10
31%
-64
- C3 -
1W2T
2
BFRA_THEMA
E:
[2-423]
--------------------------------
F
K
P
N
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
--
E
T
H
G
V
--
F
S
G
S
A
-
V
-----------
E
K
-
D
----------
G
K
M
F
L
V
Y
T
Y
----
Y
R
D
P
T
H
----
N
K
G
E
K
E
T
Q
C
V
V
M
S
E
N
-
G
L
DF
V
-
K
Y
D
-
G
N
P
-
V
I
S
---
K
P
---
P
-
E
--
E
G
T
H
A
F
--
R
D
P
K
V
N
R
S
--
N
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
K
Y
E
G
A
I
-
F
E
------
D
E
T
T
K
---
E
I
D
C
P
D
L
V
R
I
G
------
E
K
D
------
I
L
I
Y
----------
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
-
E
G
K
L
N
V
E
--
K
---
R
G
L
--
L
D
H
G
T
D
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
SW
L
R
--
T
G
--
L
Y
P
T
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
-
E
----
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
-----
K
R
K
V
F
E
T
A
K
S
--
G
T
F
-------
L
L
D
V
K
E
N
S
Y
E
I
V
C
E
F
------
S
G
E
I
--
E
L
R
M
G
N
-
E
S
E
-
E
V
V
I
T
K
S
R
D
-
E
L
I
V
D
T
T
R
S
G
V
S
G
G
-
E
-
V
R
---
K
S
T
V
-----
E
---
D
---
E
A
T
N
R
----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
S
-
I
A
F
S
F
R
I
H
P
-
E
N
V
Y
N
I
-
L
S
V
K
S
N
Q
V
K
L
-
E
-----------
22
PsiBlast_CBE
90.09
32%
-61
- C3 -
1UYP
1
BFRA_THEMA
E:
[2-423]
--------------------------------
F
K
P
N
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
--
E
T
H
G
V
--
F
S
G
S
A
-
V
-----------
E
K
-
D
----------
G
K
M
F
L
V
Y
T
Y
----
Y
R
D
P
T
H
----
N
K
G
E
K
E
T
Q
C
V
V
M
S
E
N
-
G
L
DF
V
-
K
Y
D
-
G
N
P
-
V
I
S
---
K
P
---
P
-
E
--
E
G
T
H
A
F
--
R
D
P
K
V
N
R
S
--
N
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
K
Y
E
G
A
I
-
F
E
------
D
E
T
T
K
---
E
I
E
C
P
D
L
V
R
I
G
------
E
K
D
------
I
L
I
Y
----------
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
-
E
G
K
L
N
V
E
--
K
---
R
G
L
--
L
D
H
G
T
D
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
SW
L
R
--
T
G
--
L
Y
P
T
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
-
E
----
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
-----
K
R
K
V
F
E
T
A
K
S
--
G
T
F
-------
L
L
D
V
K
E
N
S
Y
E
I
V
C
E
F
------
S
G
E
I
--
E
L
R
M
G
N
-
E
S
E
-
E
V
V
I
T
K
S
R
-
D
E
L
I
V
D
T
T
R
S
G
V
S
G
G
-
E
-
V
R
---
K
S
T
V
-----
E
---
D
---
E
A
T
N
R
----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
S
-
I
A
F
S
F
R
I
H
P
-
E
N
V
Y
N
I
-
L
S
V
K
S
N
Q
V
K
L
-
E
-----------
26
PsiBlast_CBE
89.91
31%
-62
- C3 -
1W2T
1
BFRA_THEMA
F:
[2-423]
--------------------------------
F
K
P
N
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
--
E
T
H
G
V
--
F
S
G
S
A
-
V
-----------
E
K
-
D
----------
G
K
M
F
L
V
Y
T
Y
----
Y
R
D
P
T
H
----
N
K
G
E
K
E
T
Q
C
V
V
M
S
E
N
-
G
L
DF
V
-
K
Y
D
-
G
N
P
-
V
I
S
---
K
P
---
P
-
E
--
E
G
T
H
A
F
--
R
D
P
K
V
N
R
S
--
N
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
K
Y
E
G
A
I
-
F
E
------
D
E
T
T
K
---
E
I
D
C
P
D
L
V
R
I
G
------
E
K
D
------
I
L
I
Y
----------
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
-
E
G
K
L
N
V
E
--
K
---
R
G
L
--
L
D
H
G
T
D
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
SW
L
R
--
T
G
--
L
Y
P
T
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
-
E
----
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
-----
K
R
K
V
F
E
T
A
K
S
--
G
T
F
-------
L
L
D
V
K
E
N
S
Y
E
I
V
C
E
F
------
S
G
E
I
--
E
L
R
M
G
N
-
E
S
E
-
E
V
V
I
T
K
S
R
D
-
E
L
I
V
D
T
T
R
S
G
V
S
G
G
-
E
-
V
R
---
K
S
T
V
-----
E
---
D
---
E
A
T
N
R
----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
S
-
I
A
F
S
F
R
I
H
P
-
E
N
V
Y
N
I
-
L
S
V
K
S
N
Q
V
K
L
-
E
-----------
25
PsiBlast_CBE
89.89
32%
-60
- C3 -
1UYP
5
BFRA_THEMA
B:
[2-423]
--------------------------------
F
K
P
N
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
--
E
T
H
G
V
--
F
S
G
S
A
-
V
-----------
E
K
-
D
----------
G
K
M
F
L
V
Y
T
Y
----
Y
R
D
P
T
H
----
N
K
G
E
K
E
T
Q
C
V
V
M
S
E
N
-
G
L
DF
V
-
K
Y
D
-
G
N
P
-
V
I
S
---
K
P
---
P
-
E
--
E
G
T
H
A
F
--
R
D
P
K
V
N
R
S
--
N
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
K
Y
E
G
A
I
-
F
E
------
D
E
T
T
K
---
E
I
E
C
P
D
L
V
R
I
G
------
E
K
D
------
I
L
I
Y
----------
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
-
E
G
K
L
N
V
E
--
K
---
R
G
L
--
L
D
H
G
T
D
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
SW
L
R
--
T
G
--
L
Y
P
T
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
-
E
----
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
-----
K
R
K
V
F
E
T
A
K
S
--
G
T
F
-------
L
L
D
V
K
E
N
S
Y
E
I
V
C
E
F
------
S
G
E
I
--
E
L
R
M
G
N
-
E
S
E
-
E
V
V
I
T
K
S
R
-
D
E
L
I
V
D
T
T
R
S
G
V
S
G
G
-
E
-
V
R
---
K
S
T
V
-----
E
---
D
---
E
A
T
N
R
----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
S
-
I
A
F
S
F
R
I
H
P
-
E
N
V
Y
N
I
-
L
S
V
K
S
N
Q
V
K
L
-
E
-----------
55
Fugue
89.29
30%
-58
- C3 -
1UYP
6
BFRA_THEMA
A:
[1-432]
-------------------------------
L
F
K
P
N
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
--
E
T
H
G
V
--
F
S
G
S
A
-
V
-----------
E
K
-
D
----------
G
K
M
F
L
V
Y
T
Y
----
Y
R
D
P
T
H
----
N
K
G
E
K
E
T
Q
C
V
V
M
S
E
N
-
G
L
D
F
V
-
K
Y
D
-
G
N
P
-
V
I
S
---
K
P
---
P
-
E
--
E
G
T
H
A
F
--
R
D
P
K
V
N
R
S
--
N
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
K
Y
E
G
A
I
-
F
E
D
------
E
T
T
K
---
E
I
E
C
P
D
L
V
R
I
G
------
E
K
D
------
I
L
I
Y
S
I
T
S
T
----------
N
S
V
L
F
S
M
G
E
L
K
---
E
G
K
L
N
--
V
---
E
K
R
G
L
L
D
H
G
T
D
F
Y
A
A
Q
T
F
F
G
---
T
----
D
R
V
V
V
I
G
W
L
Q
--
S
W
LR
T
G
--
L
Y
P
T
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
-
E
----
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
-----
K
R
K
V
F
E
T
A
K
S
--
G
T
F
L
L
D
----
V
---
K
E
N
S
Y
E
I
V
C
E
F
S
G
E
--
I
E
L
R
M
-------
G
-
N
E
S
-
E
E
V
V
I
T
K
S
R
D
E
L
I
V
D
T
T
R
S
G
V
S
G
G
-----
E
V
R
K
S
T
V
-----
E
---
D
---
E
A
T
N
R
----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
S
-
I
A
F
S
F
R
I
H
P
E
N
V
Y
N
I
L
S
V
K
S
N
Q
V
K
L
E
V
-----
F
E
L
E
N
I
W
L
19
PsiBlast_PDB
86.15
24%
-54
- C3 -
3SC7
4
INU2_ASPFI
X:
[24-506]
----------------------------
Q
S
N
D
Y
R
P
S
Y
H
F
T
P
D
Q
Y
W
M
N
E
P
N
G
L
I
K
I
G
S
T
W
H
L
F
F
Q
H
N
P
T
A
N
V
W
G
N
I
C
W
G
H
A
T
S
T
D
L
M
H
W
A
H
K
-----
P
T
A
I
A
D
E
N
G
V
EA
F
T
G
T
A
-
Y
YDPNNTSGLGD
S
A
-
N
----------
P
P
Y
L
A
W
F
T
G
----
Y
T
T
S
S
Q
----
T
Q
---
D
Q
R
L
A
F
S
V
D
N
-
G
A
--
T
W
T
K
F
Q
G
N
P
-
I
I
S
TSQ
E
A
---
P
-
H
--
D
I
T
G
G
L
ES
R
D
P
K
V
F
F
H
--
R
Q
S
G
N
W
I
M
V
L
A
H
G
G
Q
D
-
K
L
S
F
W
T
S
A
D
T
I
N
W
T
W
Q
S
D
L
K
S
T
S
I
----
N
G
L
S
S
DIT
G
W
E
V
P
D
M
F
E
L
P
------
V
E
G
TEETTW
V
V
M
M
T
P
A
E
G
S
P
A
G
G
N
G
V
L
A
-----
I
T
G
S
F
D
-
G
K
S
F
T
A
D
PV
D
---
A
S
T
M
W
L
D
N
G
R
D
F
D
G
A
L
S
W
V
N
VPA
S
---
D
G
R
R
I
I
A
A
V
M
N
--
S
Y
--
G
S
--
N
P
P
T
T
T
--
W
K
G
M
L
S
F
P
R
T
L
S
L
-
K
KVGT
Q
-
Q
---
H
F
V
Q
Q
P
I
T
E
L
D
T
I
S
-----
T
S
L
Q
I
---
L
A
--
N
Q
T
I
T
P
GQTL
L
S
S
I
R
G
T
A
L
D
V
R
V
A
F
Y
P
D
--
A
G
S
V
L
S
L
A
V
R
K
G
A
-
S
E
Q
-
T
V
I
K
Y
T
Q
S
D
A
T
L
S
V
D
R
T
E
S
G
D
I
S
Y
-
D
P
A
A
G
G
V
H
T
A
K
-----
L
---
E
EDG
T
G
L
V
S
----
I
R
V
L
V
D
T
C
S
V
E
V
F
G
G
Q
G
E
A
V
I
S
D
L
I
F
P
S
D
S
S
D
G
L
A
L
E
V
T
G
G
N
A
V
L
-
Q
-----------
20
PsiBlast_PDB
85.81
24%
-55
- C3 -
3RWK
8
INU2_ASPFI
X:
[24-506]
----------------------------
Q
S
N
D
Y
R
P
S
Y
H
F
T
P
D
Q
Y
W
M
N
E
P
N
G
L
I
K
I
G
S
T
W
H
L
F
F
Q
H
N
P
T
A
N
V
W
G
N
I
C
W
G
H
A
T
S
T
D
L
M
H
W
A
H
K
-----
P
T
A
I
A
D
E
N
G
V
EA
F
T
G
T
A
-
Y
YDPNNTSGLGD
S
A
-
N
----------
P
P
Y
L
A
W
F
T
G
----
Y
T
T
S
S
Q
----
T
Q
---
D
Q
R
L
A
F
S
V
D
N
-
G
A
--
T
W
T
K
F
Q
G
N
P
-
I
I
S
TSQ
E
A
---
P
-
H
--
D
I
T
G
G
L
ES
R
D
P
K
V
F
F
H
--
R
Q
S
G
N
W
I
M
V
L
A
H
G
G
Q
D
-
K
L
S
F
W
T
S
A
D
T
I
N
W
T
W
Q
S
D
L
K
S
T
S
I
----
N
G
L
S
S
DIT
G
W
E
V
P
D
M
F
E
L
P
------
V
E
G
TEETTW
V
V
M
M
T
P
A
E
G
S
P
A
G
G
N
G
V
L
A
-----
I
T
G
S
F
D
-
G
K
S
F
T
A
D
PV
D
---
A
S
T
M
W
L
D
N
G
R
D
F
D
G
A
L
S
W
V
N
VPA
S
---
D
G
R
R
I
I
A
A
V
M
N
--
S
Y
--
G
S
--
N
P
P
T
T
T
--
W
K
G
M
L
S
F
P
R
T
L
S
L
-
K
KVGT
Q
-
Q
---
H
F
V
Q
Q
P
I
T
E
L
D
T
I
S
-----
T
S
L
Q
I
---
L
A
--
N
Q
T
I
T
P
GQTL
L
S
S
I
R
G
T
A
L
D
V
R
V
A
F
Y
P
D
--
A
G
S
V
L
S
L
A
V
R
K
G
A
-
S
E
Q
-
T
V
I
K
Y
T
Q
S
D
A
T
L
S
V
D
R
T
E
S
G
D
I
S
Y
-
D
P
A
A
G
G
V
H
T
A
K
-----
L
---
E
EDG
T
G
L
V
S
----
I
R
V
L
V
D
T
C
S
V
E
V
F
G
G
Q
G
E
A
V
I
S
D
L
I
F
P
S
D
S
S
D
G
L
A
L
E
V
T
G
G
N
A
V
L
-
Q
-----------
37
HHSearch
85.72
28%
-56
- C3 -
3PIJ
3
?
A:
[31-516]
------------------------
M
A
A
K
R
N
N
R
W
Y
P
K
Y
H
I
A
S
N
G
G
W
I
N
D
P
N
G
L
C
F
Y
K
G
R
W
H
V
F
Y
Q
L
H
P
Y
G
T
Q
W
G
P
M
H
W
G
H
V
S
S
T
D
M
L
N
W
K
R
E
P
I
M
F
A
P
S
L
E
Q
E
K
D
G
V
--
F
S
G
S
A
-
V
-----------
I
D
D
N
----------
G
D
L
R
F
Y
Y
T
G
----
H
R
W
A
N
G
HDNT
G
G
D
W
Q
V
Q
M
T
A
L
P
D
N
D
E
L
T
S
-
A
-
T
K
Q
-
G
-
M
-
I
I
D
---
C
P
---
T
-
D
--
K
V
D
H
H
Y
--
R
D
P
K
V
W
K
T
--
G
D
T
W
Y
M
T
F
G
V
S
S
A
D
K
R
G
Q
M
W
L
F
S
S
K
D
M
V
R
W
E
Y
E
R
V
L
-
F
Q
H
P
----
D
P
D
V
F
---
M
L
E
C
P
D
F
S
P
I
K
D
KDG
N
-
E
K
W
------
V
I
G
F
S
A
M
G
S
K
P
S
G
F
M
N
R
N
V
S
N
A
G
Y
M
I
G
T
W
E
P
G
G
E
F
-
K
P
--
E
---
T
E
F
R
L
W
D
C
G
H
N
Y
Y
A
P
Q
S
F
N
V
-------
D
G
R
Q
I
V
Y
G
W
M
S
--
P
F
--
V
Q
--
P
I
P
M
E
D
D
G
W
C
G
Q
L
T
L
P
R
E
I
T
L
-
G
----
D
D
G
---
D
V
V
T
A
P
V
A
E
M
E
G
L
R
-----
E
D
T
L
D
H
G
S
V
T
L
D
M
D
G
E
Q
I
----
I
-
A
D
D
A
E
A
V
E
I
E
M
T
I
D
L
A
AS
T
A
E
R
A
G
L
K
I
H
A
T
E
D
G
A
Y
-
T
Y
V
A
Y
D
G
Q
I
G
R
V
V
V
D
R
Q
A
M
A
N
G
D
--
R
----
G
Y
R
A
A
P
L
T
D
A
E
L
---
A
---
S
G
K
L
D
----
L
R
V
F
V
D
R
G
S
V
E
V
Y
V
N
G
G
H
Q
V
L
S
S
Y
S
Y
A
S
E
G
P
R
A
I
K
L
V
A
E
S
G
S
L
K
V
D
S
L
K
L
H
H
M
K
S
I
G
-
1
PsiBlast_PDB
84.35
28%
-53
- C3 -
3PIG
3
?
A:
[37-508]
------------------------------
N
R
W
Y
P
K
Y
H
I
A
S
N
G
G
W
I
N
D
P
N
G
L
C
F
Y
K
G
R
W
H
V
F
Y
Q
L
H
P
Y
G
T
Q
W
G
P
M
H
W
G
H
V
S
S
T
D
M
L
N
W
K
R
E
P
I
M
F
A
P
S
L
E
Q
E
K
D
G
V
--
F
S
G
S
A
V
I
-----------
D
D
-
N
----------
G
D
L
R
F
Y
Y
T
G
H
R
WA
N
G
H
D
N
T
----
G
G
D
W
Q
V
Q
M
T
A
L
P
D
N
D
-
E
L
--
T
-
S
A
T
-
K
Q
G
-
M
I
I
---
D
C
---
P
T
D
--
K
V
D
H
H
Y
--
R
D
P
K
V
W
K
T
--
G
D
T
W
Y
M
T
F
G
V
S
S
A
D
K
R
G
Q
M
W
L
F
S
S
K
D
M
V
R
W
E
Y
E
R
V
L
-
F
Q
H
P
----
D
P
D
V
F
---
M
L
E
C
P
D
F
S
P
I
K
------
D
K
D
G
N
E
K
W
-
V
I
G
F
S
A
M
G
S
K
P
S
G
F
M
N
R
N
V
S
N
A
G
Y
M
I
G
T
W
E
-
P
G
G
E
F
K
P
--
E
---
T
E
F
R
L
W
D
C
G
H
N
Y
Y
A
P
Q
S
F
-
N
---
V
---
D
G
R
Q
I
V
Y
G
W
M
S
--
P
F
--
V
Q
--
P
I
P
M
E
D
D
G
W
C
G
Q
L
T
L
P
R
E
I
T
L
G
D
----
D
-
G
---
D
V
V
T
A
P
V
A
E
M
E
G
L
R
EDTLD
H
G
S
V
T
L
D
M
D
G
--
E
Q
I
I
A
D
------
D
A
E
A
V
E
I
E
M
T
I
D
L
A
A
S
--
T
A
E
R
A
G
L
K
I
H
A
T
E
-
D
G
A
Y
T
Y
V
A
Y
D
G
Q
I
G
R
V
V
V
D
R
Q
---
A
M
A
N
-
G
-
D
R
G
Y
R
A
A
P
L
-----
T
---
D
---
A
E
L
A
S
G
K
L
D
L
R
V
F
V
D
R
G
S
V
E
V
Y
V
N
G
G
H
Q
V
L
S
S
Y
S
Y
A
S
E
G
P
R
A
I
K
L
V
A
E
S
G
S
L
K
V
-
D
S
L
K
--------
2
PsiBlast_PDB
84.04
28%
-53
- C3 -
3PIJ
3
?
A:
[37-508]
------------------------------
N
R
W
Y
P
K
Y
H
I
A
S
N
G
G
W
I
N
D
P
N
G
L
C
F
Y
K
G
R
W
H
V
F
Y
Q
L
H
P
Y
G
T
Q
W
G
P
M
H
W
G
H
V
S
S
T
D
M
L
N
W
K
R
E
P
I
M
F
A
P
S
L
E
Q
E
K
D
G
V
--
F
S
G
S
A
V
I
-----------
D
D
-
N
----------
G
D
L
R
F
Y
Y
T
G
H
R
WA
N
G
H
D
N
T
----
G
G
D
W
Q
V
Q
M
T
A
L
P
D
N
D
-
E
L
--
T
-
S
A
T
-
K
Q
G
-
M
I
I
---
D
C
---
P
T
D
--
K
V
D
H
H
Y
--
R
D
P
K
V
W
K
T
--
G
D
T
W
Y
M
T
F
G
V
S
S
A
D
K
R
G
Q
M
W
L
F
S
S
K
D
M
V
R
W
E
Y
E
R
V
L
-
F
Q
H
P
----
D
P
D
V
F
---
M
L
E
C
P
D
F
S
P
I
K
------
D
K
D
G
N
E
K
W
-
V
I
G
F
S
A
M
G
S
K
P
S
G
F
M
N
R
N
V
S
N
A
G
Y
M
I
G
T
W
E
-
P
G
G
E
F
K
P
--
E
---
T
E
F
R
L
W
D
C
G
H
N
Y
Y
A
P
Q
S
F
-
N
---
V
---
D
G
R
Q
I
V
Y
G
W
M
S
--
P
F
--
V
Q
--
P
I
P
M
E
D
D
G
W
C
G
Q
L
T
L
P
R
E
I
T
L
G
D
----
D
-
G
---
D
V
V
T
A
P
V
A
E
M
E
G
L
R
E
D
T
L
D
H
G
S
V
T
L
D
M
D
G
--
E
Q
I
I
A
D
------
D
A
E
A
V
E
I
E
M
T
I
D
L
A
A
S
--
T
A
E
R
A
G
L
K
I
H
A
T
E
-
D
G
A
Y
T
Y
V
A
Y
D
G
Q
I
G
R
V
V
V
D
R
Q
---
A
M
A
N
-
G
-
D
R
G
Y
R
A
A
P
L
-----
T
---
D
---
A
E
L
A
S
G
K
L
D
L
R
V
F
V
D
R
G
S
V
E
V
Y
V
N
G
G
H
Q
V
L
S
S
Y
S
Y
A
S
E
G
P
R
A
I
K
L
V
A
E
S
G
S
L
K
V
-
D
S
L
K
--------