@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1852: (2016-03-29 )
MILLQLNHISKSFDGEDIFTDVDFEVKTGERIGIVGRNGAGKSTLMKIIAGVENYDSGNVSKIKNLKLGYLTQQMTLNSNATVFEEMSKPFEHIKRMESLIKEETDWLSKHANDYDSDTYKTHMSRYESLSNQFEQLEGYQYESKIKTVLHGLNFSEEDFNKPINDFSGGQKTRLSLAQMLLNEPDLLLLDEPTNHLDLETTKWLEDYLRYFKGAIVIISHDRYFLDKIVTQIYDVALGDVKRYVGNYEEFIQQRDLYYQKRMQEYESQQAEIKRLETFVEKNITRASTSGMAKSRRKILEKMERIDKPMLDAKSANIQFGFDRNTGNDVMHVKNLEIGYQTAITKPISIEVSKGDHIAIIGPNGIGKSTLIKTIANQQKALNGDITFGANLQIGYYDQKQAEFKSSKTILDYVWDQYPLMNEKDIRAVLGRFLFVQDDVKKIINDLSGGEKARLQLALLMLQRDNVLILDEPTNHLDIDSKEMLEQALQHFEGTILFVSHDRYFINQLANKVFDLTIDGGKMYLGDYQYYIEKVEEAEALKAHQEEQSVNVQAHKKSMEQSSYHNQKEQRREQRKLERQISECENEIETLETTILQIDEQLTQPEVYNNPQKANELAIQKQDSEQKLEHAMSKWEELQQKL
Atome Classification :
(20 SA)
------------------------------------------------------------------.........10...-.-------.-...20-......------...30........40........50--.......--.60...--------------.-..--..70....-..-..--80....--..----..90.......--.100..-.....110.......120.......130.......140.......150.......160.......170.......180...--....190.......200.......210----.---.---.....220.......230....------...240.......250.......260.......270.......280.......290.......300.......310.......320-.....--...330.......340.--......--------..350...-----....360.......370.......380--------------------........390-------..-----------.......400-..------------------------------------------------------------------------.--....410......-----------------------------------------------------------------------------------------------------------.420----.----........430.--------......-440.......450.......460...---....470.......480.......490----...----....500.......510......-----.--520..----.....530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------
M
I
L
L
Q
L
N
H
ISKSFD-G-------E-DIFT--DV
D
F
E
V------KTG
E
R
I
G
I
VGRNGA
G
K
S
T
L
M
K
I
I
A
G--VENYDSG--
N
V
S
K
I
K
--------------
N
-
L
K
--
L
G
Y
L
T
Q
Q
M
-TL-NS--N
A
T
V
F
E
--
E
M
----
S
K
P
F
E
H
I
K
R
M
E
--
S
L
I
K
E
E
-
T
D
W
L
S
K
HANDYDS
D
T
Y
K
T
H
M
S
R
Y
E
S
L
S
N
Q
F
E
Q
L
EG
Y
Q
Y
E
S
K
I
K
T
V
L
HGLNF
S
E
E
D
F
NKPINDFSGG
Q
K
T
R
L
S
L
A
Q
M
L
LNEP--
D
L
L
L
LDEPTNHLDL
E
T
T
K
W
L
E
D
Y
L
R
Y
F----K---
G
---
A
I
V
I
I
SH
D
R
Y
F
L
D
K
I
V
T
Q
I
Y
D
V
------
A
L
G
D
V
K
R
Y
VG
N
Y
E
E
F
I
Q
Q
R
D
L
Y
Y
Q
K
R
M
Q
E
Y
E
S
Q
Q
A
E
I
K
R
L
E
T
F
V
E
KNITRASTS
G
M
A
K
S
R
R
K
I
L
E
K
M
E
R
IDKPMLDAKSA
N
I
Q
F
G
--
F
DRNT--GND
V
M
H
V
K
N
L
E
I
GY--Q--TAITK
P
--------
I
S
I
E
VSKG-----
D
H
I
A
I
IGPNGI
G
K
S
T
L
I
K
T
I
A
N
Q
Q
KA---------------------LNG
D
I
T
F
GA---------
N
L
-----------
Q
I
G
Y
Y
D
Q
K
Q
A
-
E
F------------------------------------------------------------------------K--SS
K
T
I
L
D
Y
V
W
D
QY-----------------------------------------------------------------------------------------------------------PL------M----
N
E
K
D
I
R
A
V
L
G
R
F
--------
L
F
V
Q
D
D
-
V
K
K
I
I
N
DLSGG
E
K
A
R
L
Q
L
A
L
L
M
LQRD---
N
V
L
I
LDEPTNHLDI
D
S
K
E
M
L
E
Q
A
L
Q
HF----E
G
T
----
I
L
F
V
SH
D
R
Y
F
I
N
Q
L
ANK
V
F
D
L
T
I-----D--GG
K
M
Y
----LG
D
Y
Q
Y
Y
I
E
K
V
E
E
A
E
A
L
K
A
H
Q
E
EQSV
N
V
Q
A
H
K
K
S
M
E
Q
S
SYH
N
Q
K
E
Q
R
R
E
Q
R
K
L
E
R
Q
I
S
E
C
E
N
E
I
E
T
L
E
T
T
I
L
Q
I
D
E
QLTQPEVYNNP
Q
K
A
N
E
L
AIQKQ
D
S
E
Q
K
L
E
H
A
M
S
K
W
E
E
L
Q
QKL
2
PsiBlast_PDB
89.16
32%
-77
- C1 -
4FIN
12
ETTA_ECOLI
A:
[21-547]
--------------------------------------------------------------------------------------------
I
L
K
--
N
I
S
L
S
F
------
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
--
I
D
K
D
I
E
G
--
E
A
R
P
Q
P
--------------
D
-
I
K
--
I
G
Y
L
P
Q
E
P
-
Q
L
-
N
P
--
E
H
T
V
R
E
--
S
I
E
E
A
V
S
E
V
V
N
A
L
K
R
L
D
--
E
V
Y
A
L
Y
-
A
D
------
P
D
A
D
F
D
K
L
A
A
E
Q
G
R
L
E
E
I
---
I
Q
------
L
N
V
Q
L
E
R
A
A
D
A
L
R
L
P
--
D
W
D
A
K
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
--
D
M
L
L
L
D
E
P
T
N
H
L
D
A
E
S
V
A
W
L
E
R
F
L
H
D
F
----
E
---
G
---
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
------
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
---
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
--
W
V
R
Q
G
T
K
----
K
G
K
A
R
L
A
R
F
E
E
L
N
S
T
E
Y
Q
K
R
N
E
T
N
E
L
F
--
I
P
P
G
P
RL
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G-
D
--
R
L
L
I
D
D
--------
L
S
F
S
I
P
K
G
-----
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
---------------------
D
S
G
T
I
T
L
G
E
---------
T
V
-----------
K
L
A
S
V
D
Q
F
R
D
-
S
M
------------------------------------------------------------------------
D
--
N
S
K
T
V
W
E
E
V
S
G
G
L
-----------------------------------------------------------------------------------------------------------
D
I
------
M
KIGN
T
E
M
P
S
R
A
Y
V
G
R
F
--------
N
F
K
G
V
D
-
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
---
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
G
C
----
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
D
-----
E
--
G
K
V
E
F
F
E
G
N
F
T
E
Y
E
E
Y
K
K
R
T
L
G
A
D
A
L
E
P
K
R
-------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
88.74
32%
-69
- C1 -
3J5S
-
ETTA_ECOLI
D:
[27-553]
--------------------------------------------------------------------------------------------
I
L
K
--
N
I
S
L
S
F
------
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
--
I
D
K
D
I
E
G
--
E
A
R
P
Q
P
--------------
D
-
I
K
--
I
G
Y
L
P
Q
E
P
-
Q
L
-
N
P
--
E
H
T
V
R
E
--
S
I
EEAV
S
E
V
V
N
A
L
K
R
L
D
--
E
V
Y
A
L
Y
-
A
D
------
P
D
A
D
F
D
K
L
A
A
E
Q
G
R
L
E
E
I
---
I
Q
A
H
D
G
H
N
L
N
V
Q
L
E
R
A
A
D
A
L
R
L
P
--
D
W
D
A
K
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
--
D
M
L
L
L
D
E
P
T
N
H
L
D
A
E
S
V
A
W
L
E
R
F
L
H
D
F
----
E
---
G
---
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
------
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
---
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
--
W
V
R
Q
G
T
K
G
R
Q
S
K
G
K
A
R
L
A
R
F
E
E
L
N
S
T
E
Y
Q
K
R
N
E
T
N
E
L
F
--
I
P
P
G
P
RL
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G-
D
--
R
L
L
I
D
D
--------
L
S
F
S
I
P
K
G
-----
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
---------------------
D
S
G
T
I
T
L
G
E
---------
T
V
-----------
K
L
A
S
V
D
Q
F
R
D
-
S
M
------------------------------------------------------------------------
D
--
N
S
K
T
V
W
E
E
V
S
G
G
L
-----------------------------------------------------------------------------------------------------------
D
I
------
M
KIGN
T
E
M
P
S
R
A
Y
V
G
R
F
--------
N
F
K
G
V
D
-
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
---
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
G
C
----
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
D
-----
E
--
G
K
V
E
F
FEGN
F
T
E
Y
E
E
Y
K
K
R
T
L
G
A
D
A
L
E
P
K
R
-------------------------------------------------------------------------------------------------
30
HHSearch
87.76
31%
-73
- C- -
2IW3
7
EF3A_YEAST
A:
[439-979]
------------------------------------------------------------------------
C
E
F
S
L
A
Y
G
-
A
-------
K
-
I
L
L
N
--
K
T
Q
L
R
L
------
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
--
G
Q
V
--
D
G
--
F
P
T
-
Q
E
--------------
E
-
C
R
--
T
V
Y
V
E
H
D
I
-
D
G
T
H
S
--
D
T
S
V
L
D
--
F
V
----
F
E
S
G
V
---------------------------------------------------
G
T
K
E
A
I
K
D
K
L
I
E
F
G
F
T
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
---
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
K
-----
A
Y
E
E
-------
L
S
N
T
D
L
--------------------
E
---
F
K
F
P
E
P
--
G
Y
--
L
--
E
--
G
V
K
T
K
--
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
P-
G
TS
K
P
Q
I
T
D
--------
I
N
F
Q
C
S
L
S
-----
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
---------------------
T
S
G
E
V
Y
T
H
E
---------
N
C
-----------
R
I
A
Y
I
K
Q
H
A
F
A
H
I
------------------------------------------------------------------------
E
SH
L
D
K
T
P
S
E
Y
I
Q
W
R
F
Q
TGEDRETMDRANRQINEND
A
E
A
M
N
K
I
F
K
I
EG
T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
NIGMKS
E
R
W
V
P
M
M
SVD
N
A
W
I
P
RGELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
GQF
R
P
------
L
----
T
R
K
E
I
E
E
H
C
S
M
L
--------
G
L
D
P
E
I
V
S
H
S
R
I
R
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
---
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
G
A
L
S
K
A
L
K
E
F
----
E
G
G
----
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
K
------
D
--
G
R
M
T
P
----
S
---------------------------------------------------------------------------------------------------------------------
34
HHSearch
63.00
20%
-70
- C1 -
3OZX
5
?
A:
[4-468]
-------------------------------------------------------------------------
E
V
I
H
R
Y
K
-
V
N------
G
-
F
K
L
F
--
G
L
P
T
-
P
------
K
N
N
T
I
L
G
V
L
G
K
N
G
V
G
K
T
T
V
L
K
I
L
A
G
--
E
I
I
P
N
F
G
--
D
P
N
S
K
V
G
K
D
E
V
L
K
R
F
R----
G
-
K
E
--
I
Y
N
Y
F
K
E
L
-
Y
S
--
N
--
E
L
K
I
V
H
--
K
I
----
Q
Y
V
E
Y
A
-
S
K
F
-------------
L
------------------
K
G
T
V
N
E
I
L
---
T
K
I
D
E
R
G
K
K
D
E
V
K
E
L
L
N
M
T
N
-
L
W
N
K
D
A
N
I
L
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
A
--
D
V
Y
I
F
D
Q
P
S
S
Y
L
D
V
R
E
R
M
N
M
A
K
A
I
R
E
L
L
K--
N
---
K
---
Y
V
I
V
V
D
H
D
L
I
V
L
D
Y
L
T
D
L
I
H
I
I
------
Y
-
G
E
S
S
V
Y
-
G
R
V
S
K
S
Y
A
A
R
V
G
I
------------------
N
N
F
L
K
G
Y
L
P
A
E
N
M
K
I
R
P
D
E
I
K
F
M
L
K
-----------------------------
L
K
T
K
M
K
W
T
K
I
I
K
K
L
--
G
--
D
F
Q
L
V
V
--------
D
N
G
E
A
K
E
G
-----
E
I
I
G
I
L
G
P
N
G
I
G
K
T
T
F
A
R
I
L
V
G
E
I
T
A
---------------------
D
E
G
S
V
T
P
E
K
----------
Q
-----------
I
L
S
Y
K
P
Q
R
I
F
--
P
------------------------------------------------------------------------
N
--
Y
D
G
T
V
Q
Q
Y
L
E
N
A
S
-----------------------------------------------------------------------------------------------------------
K
D
ALS---
T
----
S
S
W
F
F
E
E
V
T
K
R
L
--------
N
L
H
R
-
L
-
L
E
S
N
V
N
D
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
A
---
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
R
Y
I
V
A
K
A
I
K
R
V
T
R
E
R
K
A
V
----
T
F
I
I
D
H
D
L
S
I
H
D
Y
I
A
D
R
I
I
V
F
K
------
G
--
E
P
-
E
K
----
A
G
L
-------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
62.77
24%
-54
- C1 -
1YQT
4
?
A:
[44-481]
------------------------------------------------------------------------------------------------------
V
------
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
QL
I
P
N
L
C
G
D
--
N
D
S
W
D
G
--------------
V
-
I
R
-----------
A
F
-
R
G
--
N
-------
E
L
----
Q
N
Y
F
E
K
L
K
N
G
E
I
R
P
V
V
K
P
Q
Y
V
D
L
I
P
K
A
V
K
-----------------
G
K
V
I
E
L
L
K
K
A
D
E
T
G
K
L
E
E
V
V
K
A
L
E
L
-
E
N
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
--
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
----
S
E
E
G
K
---
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
-
S
D
I
I
H
V
------
V
Y
G
E
----
P
G
V
Y
G
I
F
S
Q
-------------------------------
P
K
G
T
R
N
G
I
N
E
F
L
R
G
Y
L
K
D
E
N
V
R
F
R
P
Y
------
E
I
K
F
-----
T
K
T
--
G
E
R
V
------
E
I
E
R
--
E
--
T
L
V
T
Y
P
R
L
V
K
D
YGS
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
---------------------
T
E
G
K
I
E
W
-----------
D
L
-----------
T
V
A
Y
---------------------------------------------------------------------------------
K
--
P
Q
Y
I
K
A
D
Y
E
G
T
V
Y
-----------------------------------------------------------------------------------------------------------
E
L
------
L
----
S
K
I
D
A
S
K
L
N
S
N
F
Y
K
T
E
LLKP
L
G
I
I
D
L
-
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
G
-----
E
--
P
G
K
----------------------------------------------------------------------------------------------------------------------------
33
HHSearch
62.31
23%
-56
- C1 -
1YQT
4
?
A:
[25-479]
------------------------------------------------------------------------
E
D
C
V
H
R
Y
G
-
V
N------
A
-
F
V
L
Y
--
R
L
P
-
V
V
------
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
--
Q
L
I
P
N
L
C
GD
N
D
S
W
D
G
--------------
V
-
I
R
A
F
R
G
N
E
L
Q
N
Y
F
E
K
-
L
K
--
N
G
E
I
R
P
--
V
V
----
K
P
Q
Y
V
D
L
I
P
-------------
K
A
----------
V
K
G
-------
K
V
I
---
E
L
L
K
K
A
D
E
T
G
K
L
E
E
V
V
K
A
L
E
L
E
N
-
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
--
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
E
-
G
---
K
---
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
------
Y
G
E
P
-----
G
V
Y
G
I
F
S
Q
P
K
G
T
R
N
---------------
G
I
N
E
F
L
R
G
Y
L
K
D
---
E
-----
N
-
V
R
F
R
P
Y
E
-
I
K
F
T
K
T
-
G
E
R
V
---------
E
I
E
--
R
E
T
L
V
T
Y
P
R
L
V
K
D
Y
--
G
--
S
F
R
L
E
V
--------
E
P
G
E
I
K
K
G
-----
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
---------------------
T
E
G
K
I
E
W
D
L
----------------------
T
V
A
Y
K
P
Q
Y
I
K
-
A
-------------------------------------------------------------------------
D
--
Y
E
G
T
V
Y
E
L
L
S
K
I
D
-----------------------------------------------------------------------------------------------------------
A
S
K
L
----
N
----
S
N
F
Y
K
T
E
L
L
K
P
L
--------
G
I
I
D
-
L
-
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
------
G
--
E
P
-----------------------------------------------------------------------------------------------------------------------------
31
HHSearch
60.54
21%
-62
- C1 -
3BK7
4
?
A:
[83-546]
--------------------------------------------------------------------
A
I
S
I
V
N
L
P
E
Q
L
D
-
E
D
CVHRYG
V
-
N
A
F
V
--
L
Y
R
L
P
I
V
-----
K
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
--
Q
L
I
P
N
L
C
--
E
D
N
D
S
W
----------------
D
N
--
V
I
R
A
F
R
G
N
-
E
L
-
Q
N
--
Y
F
E
R
L
K
N
G
E
I
----
R
P
V
V
K
P
Q
--------
Y
V
D
----------------
L
L
P
K
A
V
K
--
G
K
V
R
E
L
L
---
K
K
V
D
E
V
G
K
F
E
E
V
V
K
E
L
E
L
E
N
-
V
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
--
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
-
G
---
K
---
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
------
Y
G
E
P
-----
G
V
Y
G
I
F
S
K
P
K
G
T
R
N
---------------
G
I
N
E
F
L
Q
G
Y
L
K
D
E
------
N
V
R
F
R
----------
P
----
Y
E
I
R
F
T
K
L
SE
R
V
D
V
E
--
R
E
T
L
V
E
Y
P
R
L
V
K
D
Y
--
G
--
S
F
K
L
E
V
--------
E
P
G
E
I
R
K
G
-----
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
---------------------
T
E
G
K
V
E
W
D
L
----------------------
T
V
A
Y
K
P
Q
Y
I
K
-
A
-------------------------------------------------------------------------
E
--
Y
E
G
T
V
Y
E
L
L
S
K
I
D
-----------------------------------------------------------------------------------------------------------
S
S
K
L
----
N
----
S
N
F
Y
K
T
E
L
L
K
P
L
--------
G
I
I
D
-
L
-
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
----------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
58.91
18%
-46
- C1 -
3J16
4
RLI1_YEAST
B:
[1-608]
MS
D
K
N
S
R
I
A
I
V
S
ADKCKPKKCRQ
E
C
K
R
S
C
P
V
V
K
T
GKLC
I
E
V
T
PTSK
I
A
F
I
S
EILCIGCG
I
C
V
K
K
CP
F
D
A
I
Q
I
I
N
L
P
T
N
L
E
-
A
-------
H
-
V
T
H
R
YS
A
N
S
F
K
L
H
R
L
P
T
P
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
--
K
Q
K
P
N
L
G
--
R
F
D
D
P
P
--------------
E
-----
W
Q
E
I
I
K
Y
F
-
R
G
-
S
E
--
L
Q
N
Y
F
T
--
K
M
----
L
E
D
-----
D
I
K
--
A
I
I
K
P
Q
-----------
Y
V
D
N
I
P
R
A
I
K
G
P
V
Q
K
V
G
E
L
L
K
L
R
-
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
-
E
N
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
--
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
Q
R
L
N
A
A
Q
I
I
R
S
L
----
L
---
A
P
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
------
Y
G
V
P
S
V
Y
G
V
V
T
--------------------
L
P
A
S
V
R
E
G
I
N
I
F
L
D
G
H
I
P
A
E
N
---------------
L
R
F
R
T
E
A
L
Q
F
R
I
A
D
A
T
E
D
--
L
Q
N
D
S
--
A
S
R
A
F
S
Y
P
S
L
K
K
T
Q
--
G
--
D
F
V
L
N
V
--------
E
E
G
E
F
S
D
S
-----
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
---------------------
D
E
G
Q
D
I
P
-----------
K
L
-----------
N
V
S
M
K
P
Q
K
I
A
-
P
K
------------------------------------------------------------------------
F
--
P
G
T
V
R
Q
L
F
F
K
K
I
R
-----------------------------------------------------------------------------------------------------------
G
Q
------
F
----
L
N
P
Q
F
Q
T
D
V
V
K
P
--------
L
R
I
D
D
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
----
I
L
H
N
K
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
G
-----
I
--
P
S
K
---------
N
A
H
A
R
A
P
E
S
L
L
T
G
C
N
R
F
L
K
N
L
N
V
T
F
R
R
D
P
N
S
F
R
P
R
I
N
K
L
D
S
Q
M
D
K
E
Q
K
S
S
G
N
Y
F
F
L
D
N
T
G
I
------------------------------------------------------
32
HHSearch
58.30
19%
-52
- C1 -
3J16
2
RLI1_YEAST
B:
[81-560]
------------------------------------------------------------------------
A
H
V
T
H
R
Y
S
-
A
-------
N
S
F
K
L
H
--
R
L
P
-
T
P
------
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
--
K
Q
K
P
N
L
G
--
R
F
D
D
P
P
--------------
E
W
Q
E
I
-
I
K
Y
F
-
R
G
S
-
E
L
-
Q
N
Y
F
T
K
M
L
E
D
--
D
I
----
K
A
I
I
K
P
Q
Y
V
-------
D
N
I
-
P
R
------------
A
I
K
G
P
V
Q
---
K
V
G
E
L
L
K
L
-
R
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
E
N
-
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
--
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
Q
R
L
N
A
A
Q
I
I
R
S
L
L
A
P
-
T
---
K
---
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
------
Y
G
V
P
S
V
-
Y
-
G
V
V
T
L
P
A
S
V
R
E
------------------
G
I
N
I
F
L
D
G
H
I
P
A
----
E
N
L
R
F
R
T
---
E
A
L
Q
-
F
R
I
A
D
A
-
T
E
--
D
L
------
Q
N
D
S
--
A
S
R
A
F
S
Y
P
S
L
K
K
T
Q
--
G
--
D
F
V
L
N
V
--------
E
E
G
E
F
S
D
S
-----
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
---------------------
D
E
G
Q
D
I
P
-----------
K
L
-----------
N
V
S
M
K
P
Q
K
I
A
-
P
K
---------------------------------------------------------------------------
F
P
G
T
V
R
Q
L
F
F
K
K
I
-----------------------------------------------------------------------------------------------------------
R
G
QF----
L
----
N
P
Q
F
Q
T
D
V
V
K
P
L
--------
R
I
D
D
-
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
K
K
T
----
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
------
G
I
P
S
K
N
A
H
----
A
R
A
P
E
S
L
L
T
G
------------------------------------------------------------------------------------------------------------
47
HHSearch
55.71
25%
-83
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-223]
-------------------------------------------------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
-
E
-------
V
-
V
V
S
K
--
D
I
N
L
D
I
------
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
--
L
E
T
I
T
S
G
--
D
L
F
I
G
E
KRMNDTPPA-----
E
-
R
G
--
V
G
M
V
F
Q
S
Y
-
A
L
-
Y
P
--
H
L
S
V
A
E
--
N
M
----
S
F
G
L
K
L
A
G
A
--------------------------------------------
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
--
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
------
D
A
G
R
V
A
Q
V
-
G
K
P
L
E
L
Y
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
54.79
28%
-52
- C1 -
2IWH
8
EF3A_YEAST
A:
[442-760]
---------------------------------------------------------------------------
S
L
A
Y
G
-
A
-------
K
-
I
L
L
N
--
K
T
Q
L
R
L
------
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
--------
N
G
--
Q
V
D
------------------------
G
F
P
T
Q
E
------
E
--
C
R
T
V
Y
V
--
E
---------------------------------
H
D
I
D
G
----
T
H
-
S
D
T
S
V
L
D
F
V
F
E
S
--
G
V
G
T
K
E
A
I
K
D
K
L
I
E
F
G
F
T
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
---
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
--
C
P
A
A
K
A
Y
E
E
L
S
N
T
D
L
E
F
K
----
F
P
E
P
G
Y
L
E
G
-----
V
K
T
K
Q
K
A
I
V
K
----------------------------------
V
T
N
M
E
F
Q
Y
--
P
---
G
T
S
K
P
QITD----
I
N
F
Q
C
S
L
S
-----
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
---------------------
T
S
G
E
V
Y
T
H
E
---------
N
C
-----------
R
I
A
Y
I
--
K
Q
H
-
A
F
------------------------------------------------------------------------
A
--
H
I
E
S
H
L
D
K
T
P
S
E
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
54.76
28%
-53
- C1 -
2IW3
6
EF3A_YEAST
A:
[442-760]
---------------------------------------------------------------------------
S
L
A
Y
G
-
A
-------
K
-
I
L
L
N
--
K
T
Q
L
R
L
------
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
--------
N
G
--
Q
V
D
------------------------
G
F
P
T
Q
E
E
-
C
-------
R
T
V
Y
V
--
E
---------------------------------
H
D
I
D
G
----
T
H
-
S
D
T
S
V
L
D
F
V
F
E
S
--
G
V
G
T
K
E
A
I
K
D
K
L
I
E
F
G
F
T
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
---
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
--
C
P
A
A
K
A
Y
E
E
L
S
N
T
D
L
E
F
K
----
F
P
E
P
G
Y
L
E
G
-----
V
K
T
K
Q
K
A
I
V
K
----------------------------------
V
T
N
M
E
F
Q
Y
--
P
---
G
T
S
K
P
QITD----
I
N
F
Q
C
S
L
S
-----
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
---------------------
T
S
G
E
V
Y
T
H
E
---------
N
C
-----------
R
I
A
Y
I
--
K
Q
H
-
A
F
------------------------------------------------------------------------
A
--
H
I
E
S
H
L
D
K
T
P
S
E
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
54.32
28%
-52
- C1 -
2IX3
6
EF3A_YEAST
A:
[442-760]
---------------------------------------------------------------------------
S
L
A
Y
G
-
A
-------
K
-
I
L
L
N
--
K
T
Q
L
R
L
------
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
--------
N
G
--
Q
V
D
------------------------
G
F
P
T
Q
E
------
E
--
C
R
T
V
Y
V
--
E
---------------------------------
H
D
I
D
G
----
T
H
-
S
D
T
S
V
L
D
F
V
F
E
S
--
G
V
G
T
K
E
A
I
K
D
K
L
I
E
F
G
F
T
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
---
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
--
C
P
A
A
K
A
Y
E
E
L
S
N
T
D
L
E
F
K
----
F
P
E
P
G
Y
L
E
G
-----
V
K
T
K
Q
K
A
I
V
K
----------------------------------
V
T
N
M
E
F
Q
Y
--
P
---
G
T
S
K
P
QITD----
I
N
F
Q
C
S
L
S
-----
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
---------------------
T
S
G
E
V
Y
T
H
E
---------
N
C
-----------
R
I
A
Y
I
--
K
Q
H
-
A
F
------------------------------------------------------------------------
A
--
H
I
E
S
H
L
D
K
T
P
S
E
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
54.07
25%
-89
- C1 -
1Z47
1
?
A:
[11-237]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
PG
G
--
A
R
S
V
R
G
--------
V
S
F
Q
I
R
E
G
-----
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
---------------------
T
K
G
D
V
W
I
G
G
KRVTDLPPQ
K
R
-----------
N
V
G
L
V
F
Q
N
Y
A
--
L
------------------------------------------------------------------------
F
--
Q
H
M
T
V
Y
D
N
V
S
F
G
L
-----------------------------------------------------------------------------------------------------------
R
E
K
RVP
K
D
E
----
M
D
A
R
V
R
E
L
L
R
F
M
--------
R
L
E
S
-
Y
-
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
---
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
----
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
------
E
--
G
N
V
E
Q
----
F
G
T
P
E
E
V
Y
E
K
P
-----------------------------------------------------------------------------------------------------------
51
HHSearch
54.01
24%
-76
- C1 -
3D31
-
?
A:
[1-217]
--------------------------------------------------------------------
M
I
E
I
E
S
L
S
R
K
W
K
-
N
---------
F
S
L
D
--
N
L
S
L
K
V
------
E
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
--
F
H
V
P
D
S
G
--
R
I
L
L
D
G
KDVTDLSPE-----
K
-
H
D
--
I
A
F
V
Y
Q
N
Y
-
S
L
-
F
P
--
H
M
N
V
K
K
--
N
L
----
E
F
G
M
R
M
K
K
-----------------------------------------------
I
K
D
P
K
R
V
L
D
T
A
R
D
L
K
I
E
H
-
L
L
D
R
N
P
L
T
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
P
--
K
I
L
L
L
D
E
P
L
S
A
L
D
P
R
T
Q
E
N
A
R
E
M
L
S
V
L
H
K
KN
K
---
L
---
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
D
R
I
A
V
V
------
M
D
G
K
L
I
Q
V
-
G
K
P
E
E
I
F
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
53.27
25%
-78
- C1 -
3TUI
1
METN_ECOLI
C:
[23-253]
-------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
-
Q
GTRT---
I
-
Q
A
L
N
--
N
V
S
L
H
V
------
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
--
L
E
R
P
T
E
G
--
S
V
L
V
D
G
QELTTLSESELTKA
R
-
R
Q
--
I
G
M
I
F
Q
H
F
-
N
L
-
L
S
--
S
R
T
V
F
G
--
N
V
----
A
L
P
L
E
L
D
N
T
--------------------------------------------
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
--
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
NRRL
G
---
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
------
S
N
G
E
L
I
E
Q
-
D
T
V
S
E
V
F
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
53.19
24%
-73
- C1 -
1Z47
1
?
A:
[13-235]
-------------------------------------------------------------------
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
-------
A
-
R
S
V
R
--
G
V
S
F
Q
I
------
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
--
L
E
R
P
T
K
G
--
D
V
W
I
G
G
KRVTDLPPQ-----
K
-
R
N
--
V
G
L
V
F
Q
N
Y
-
A
L
-
F
Q
--
H
M
T
V
Y
D
--
N
V
----
S
F
G
L
R
E
K
R
V
--------------------------------------------
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
-
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
--
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
---
V
---
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
------
H
E
G
N
V
E
Q
F
-
G
T
P
E
E
V
Y
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
52.55
23%
-60
- C1 -
1OXX
25
?
K:
[1-309]
------------------------------------------------------------------
M
V
R
I
I
V
K
N
V
S
K
V
F
K
-
K
GK-----
V
-
V
A
L
D
--
N
V
N
I
N
I
------
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
--
L
D
V
P
S
T
G
--
E
L
Y
F
D
D
RLVASNGKLIVPPE
D
-
R
K
--
I
G
M
V
F
Q
T
W
-
A
L
-
Y
P
--
N
L
T
A
F
E
--
N
I
----
A
F
P
L
T
N
M
K
--------------------------------------------
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
-
V
L
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
--
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
QSRL
G
---
V
---
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
------
V
K
G
K
L
V
Q
V
-
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
-------------
L
I
G
E
I
N
E
L
E
G
K
-------------
V
T
N
E
G
-
V
--
V
I
---
G
S
--
L
R
F
P
--
V
S
V
S
S
--
D
R
A
I
I
G
I
R
P
E
D
V
K
L
--
S
--
K
D
V
I
K
D
--------
D
S
W
I
L
V
G
K
-----
G
K
V
K
V
I
G
Y
Q
G
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
52.09
23%
-61
- C1 -
2R6F
3
?
A:
[486-944]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
TG
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L-
G
---
N
---
T
L
I
V
V
E
H
D
E
D
T
M
L
-
A
A
D
Y
L
I
D
I
G
PGAGI
H
G
G
E
V
V
A
A
-
G
T
P
E
E
V
M
N
D
P
N
S
L
T
-----------------
G
Q
Y
L
S
---
G
------------
K
K
F
-----
I
P
I
P
A
-------------
E
R
R
R
P
--
D
G
R
W
L
E
V
V
G
A
R
--------
E
H
N
L
K
N
--------
V
S
V
K
I
P
L
G
-----
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
LHRAK
A
K
P
G
EHRDIRGLEH
L
D
K
V
I
D
I
D
Q
---------
S
P
IGRTPRSN
P
A
T
Y
T
G
V
F
D
D
I
R
D
-
V
F
A
S
T
N
E
A
K
V
R
GYKKGRFSFNVKGGRCEACHGDG
I
I
K
I
E
M
H
FL
P
D
V
Y
V
P
CEVCHGKRYNRETLEVTYKGKN
I
A
E
V
--
L
D
M
T
V
E
D
A
L
D
F
F
A
-----------------------------------------------------------------------------------------------------------
S
I
------
P
----
K
I
K
R
K
L
E
T
L
Y
D
V
--------
G
L
G
Y
M
K
-
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
NGR
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
N
-
G
D
T
----
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
EGGDR
G
--
G
Q
I
V
A
----
V
G
T
P
E
E
V
A
E
V
K
-----------------------------------------------------------------------------------------------------------
45
HHSearch
51.81
23%
-80
- C1 -
1V43
-
?
A:
[10-237]
------------------------------------------------------------------
M
V
E
V
K
L
E
N
L
T
K
R
F
G
-
N
-------
F
-
T
A
V
N
--
K
L
N
L
T
I
------
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
--
L
E
E
P
T
E
G
--
R
I
Y
F
G
D
RDVTYLPPK-----
D
-
R
N
--
I
S
M
V
F
Q
----------
H
M
T
V
Y
E
--
N
I
----
A
F
P
L
--
K
K
F
--------------------------------------------
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
-
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
--
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
---
V
---
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
------
N
R
G
Q
L
L
Q
I
-
G
S
P
T
E
V
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------