@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1859: (2016-03-29 )
MSKTQHEVNQNIDPLKMAESLELEQLNEKTLNDMRSGSEVLVEALLKENVDYLFGYPGGAVLPLYDTFYDGKIKHILARHEQGAVHAAEGYARVSGKTGVVVVTSGPGATNVMTGITDAHCDSLPLVVFTGQVATPGIGKDAFQEADILSMTSPITKQNYQVKRVEDIPKIVHEAFHVANSGRKGPVVIDFPKDMGVLATNVDLCDEINIPGYEVVTEPENKDIDTFISLLKEAKKPVVLAGAGINQSKSNQLLTQFVNKHQIPTVTTLLGLGAVPYEDTLFLGMGGMHGSYASNMALTECDLLINLGSRFDDRLASKPDAFAPNAKIVHVDIDPSEINKVIHVDLGIIADCKRFLECLNDKNVETIEHSDWVKHCQNNKQKHPFKLGEEDQVFCKPQQTIEYIGKITNGEAIVTTDVGQHQMWAAQFYPFKNHGQWVTSGGLGTMGFGIPSSIGAKLANPDKTVVCFVGDGGFQMTNQEMALLPEYGLDVKIVLINNGTLGMVKQWQDKFFNQRFSHSVFNGQPDFMKMAEAYGVKGFLIDKPEQLEEQLDAAFAYQGPVLIEVRISPTEAVTPMVPSGKSNHEMEGL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........--70.-........80........90....-....100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200-.......210.------......220.......230.......240...-..-..250.......260.......270....--..-.280.......290..-......300.......310.......320..---------..--...330.......340.......350.......360....------.---.------.370.......380......-.390-.-------.....--.400.......410-.........420.....-..430.......440.......450.......460.......470.......480.......490.......500.......510--------....--------...--.520.......530.......540.......550--....----...560.......570.......580.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSK
T
Q
H
E
V
NQNI
D
P
L
K
M
A
E
S
L
E
L
E
Q
L
N
E
K
T
L
N
D
M
R
S
G
S
E
V
L
V
E
A
L
L
K
ENV
D
Y
L
FGYPG
G
A
V
L
P
L
Y
DTFY--D-
G
-
K
I
K
H
I
L
A
RHEQG
A
V
HAAE
G
Y
A
RVS-GKT
G
V
V
V
V
TSGPGA
T
N
V
MTGITDAHCDSL
P
L
V
V
F
TGQVATPGIG
K
D
A
F
QEA
D
I
L
SMTSPITKQN
Y
Q
V
K
R
V
E
D
I
P
K
I
V
H
E
A
F
H
V
ANSGRKG
P
V
V
I
DFPKDMG
V
L
ATNV-DLCDEINIPG
Y
------
E
V
V
TEPENK
D
I
D
T
F
I
S
L
L
K
EAKK
P
V
V
L
A
GAGI-NQ-
S
K
S
N
Q
L
L
T
Q
F
V
N
KHQI
P
T
V
T
T
L
L
GLGAVP--YE-
D
T
L
F
L
GMGGMHG-SYA-SNM
A
L
T
E
C
D
L
L
I
N
L
G
S
R
F
D
D
R
LASKPDAFAP---------N
A
--
K
I
V
H
V
DI
D
P
S
EIN
K
V
I
H
V
D
L
G
I
I
A
D
C
K
R
F
L
E
C
LNDKNVET------I---
E
------
H
S
D
W
V
K
H
C
QNNKQKHPFKLG-EED
Q
-
V
-------
F
C
K
P
Q
--
Q
T
I
E
Y
I
G
KITNG---
E
A
I
V
T
TDVGQH
Q
M
W
A
A
Q-FYPFKNHG
Q
W
V
TSGGLGTMGFGI
P
S
S
I
G
AKLANPD
K
T
V
V
C
F
VGDGG
F
Q
MTN
Q
E
M
ALLPEYG
L
D
V
K
I
V
L
INNG
T
L
G
M
V
K
Q
W
Q
D
K
F
---------
F
N
Q
R
--------FSH--SVFNGQ
P
D
F
M
K
M
A
E
AYGV
K
G
F
LID
K
P
E
Q
L
E
E
Q
L
D
--
A
A
FA----YQG
P
V
L
I
E
V
R
ISPTEAVTPMVPSGKSNHEMEGL
22
PsiBlast_CBE
92.91
41%
-83
- C2 -
1T9D
9
ILVB_YEAST
C:
[79-648]
------------------------------
F
V
G
L
-
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
--
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
-
P
I
P
T
K
-------------------
N
K
A
A
D
----
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
--
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
--
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
------
K
---
E
------
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
M
-
E
E
T
P
G
S
-------
K
I
K
P
Q
--
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
-
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
--
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
---------
23
PsiBlast_CBE
92.87
41%
-83
- C2 -
1T9D
9
ILVB_YEAST
B:
[76-648]
---------------------------
D
T
S
F
V
G
L
-
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
--
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
-
P
I
P
---------------
F
V
M
Q
S
I
N
K
A
A
D
----
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
--
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
--
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
------
K
---
E
------
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
M
-
E
E
T
P
G
S
-------
K
I
K
P
Q
--
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
-
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
--
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
---------
25
PsiBlast_CBE
92.51
41%
-80
- C2 -
1T9B
9
ILVB_YEAST
B:
[75-648]
--------------------------
M
D
T
S
F
V
G
L
-
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
--
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
-
P
I
P
T
K
T
T
L
P
S
-
R
A
Q
D
--
E
F
V
M
Q
S
I
N
K
A
A
D
----
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
--
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
--
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
------
K
---
E
------
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
M
-
E
E
T
P
G
S
-------
K
I
K
P
Q
--
T
V
I
K
K
L
S
K
V
A
N
D
TG
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
-
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
--
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
---------
26
PsiBlast_CBE
92.33
41%
-79
- C2 -
1T9A
9
ILVB_YEAST
B:
[74-648]
-------------------------
D
M
D
T
S
F
V
G
L
-
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
--
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
-
P
I
P
T
K
T
T
L
P
--Q
D
----
E
F
V
M
Q
S
I
N
K
A
A
D
----
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
--
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
--
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
------
K
---
E
------
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
M
-
E
E
T
P
G
S
-------
K
I
K
P
Q
--
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
-
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
--
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
---------
27
PsiBlast_CBE
92.13
41%
-80
- C2 -
1N0H
9
ILVB_YEAST
B:
[73-648]
------------------------
P
D
M
D
T
S
F
V
G
L
-
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
--
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
-
P
I
P
T
K
T
T
L
P
S
-SRAQ
D
-
E
F
V
M
Q
S
I
N
K
A
A
D
----
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
--
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
--
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
------
K
---
E
------
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
M
-
E
E
T
P
G
S
-------
K
I
K
P
Q
--
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
-
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
--
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
---------
24
PsiBlast_CBE
91.97
41%
-80
- C2 -
1T9C
7
ILVB_YEAST
B:
[74-648]
-------------------------
D
M
D
T
S
F
V
G
L
-
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
--
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
-
P
I
P
T
K
T
T
L
P
--Q
D
----
E
F
V
M
Q
S
I
N
K
A
A
D
----
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
--
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
--
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
------
K
---
E
------
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
M
-
E
E
T
P
G
S
-------
K
I
K
P
Q
--
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
-
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
--
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
---------
4
PsiBlast_PDB
91.80
41%
-79
- C2 -
1T9C
7
ILVB_YEAST
A:
[75-648]
--------------------------
M
D
T
S
F
V
G
L
-
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
--
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
-
P
I
P
T
K
T
T
L
P
S
-S
R
A
Q
D
-
E
F
V
M
Q
S
I
N
K
A
A
D
----
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
--
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
--
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
------
K
---
E
------
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
M
-
E
E
T
P
G
S
-------
K
I
K
P
Q
--
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
-
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
--
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
---------
1
PsiBlast_PDB
91.75
41%
-80
- C2 -
1N0H
9
ILVB_YEAST
A:
[73-648]
------------------------
P
D
M
D
T
S
F
V
G
L
-
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
--
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
-
P
I
P
T
K
T
T
L
P
S
-TS
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
----
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
--
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
--
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
------
K
---
E
------
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
M
-
E
E
T
P
G
S
-------
K
I
K
P
Q
--
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
-
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
--
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
---------
39
HHSearch
91.71
43%
-80
- C2 -
1T9B
9
ILVB_YEAST
A:
[75-654]
---------------------------
M
D
T
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
--
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
-
P
I
P
-------------------
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
-
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
--
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
--
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
------
K
---
E
------
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
M
E
E
T
P
G
-
S
-------
K
I
K
P
Q
--
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
-
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
--------
Y
S
H
--
T
H
-
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
--
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
---
2
PsiBlast_PDB
91.71
41%
-78
- C2 -
1T9A
9
ILVB_YEAST
A:
[74-648]
-------------------------
D
M
D
T
S
F
V
G
L
-
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
--
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
-
P
I
P
T
K
T
T
L
P
--TS
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
----
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
--
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
--
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
------
K
---
E
------
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
M
-
E
E
T
P
G
S
-------
K
I
K
P
Q
--
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
-
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
--
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
---------
21
PsiBlast_CBE
91.67
41%
-79
- C2 -
1T9D
10
ILVB_YEAST
D:
[75-648]
--------------------------
M
D
T
S
F
V
G
L
-
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
--
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
-
P
I
P
T
K
T
T
L
P
S
-SRAQD-
E
F
V
M
Q
S
I
N
K
A
A
D
----
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
--
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
EARRAAAEG
R
G
--
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
------
K
---
E
------
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
M
-
E
E
T
P
G
S
-------
K
I
K
P
Q
--
T
V
I
K
K
L
S
K
V
A
N
D
TGR
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
-
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
--
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
---------
5
PsiBlast_PDB
91.48
41%
-81
- C2 -
1T9D
9
ILVB_YEAST
A:
[75-648]
--------------------------
M
D
T
S
F
V
G
L
-
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
--
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
-
P
I
P
T
K
T
T
L
P
--TS
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
----
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
--
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
--
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
------
K
---
E
------
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
M
-
E
E
T
P
G
S
-------
K
I
K
P
Q
--
T
V
I
K
K
L
S
K
V
A
N
D
TG
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
-
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
--
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
---------
6
PsiBlast_PDB
90.97
41%
-84
- C2 -
1JSC
8
ILVB_YEAST
A:
[26-591]
------------------------
P
D
M
D
T
S
F
V
G
L
-
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
--
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
-
P
I
P
T
K
T
T
L
P
S
-AQ
D
---
E
F
V
M
Q
S
I
N
K
A
A
D
----
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
--
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
--
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
------
K
---
E
------
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
M
-
E
E
T
P
G
S
-------
K
I
K
P
Q
--
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
-
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
---------------------------------
S
H
--
T
-
H
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
--
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
-------------------
3
PsiBlast_PDB
90.94
41%
-81
- C2 -
1T9B
9
ILVB_YEAST
A:
[75-648]
--------------------------
M
D
T
S
F
V
G
L
-
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
--
N
-
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
-
P
I
P
---------------
F
V
M
Q
S
I
N
K
A
A
D
----
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
--
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
--
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
------
K
---
E
------
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
M
-
E
E
T
P
G
S
-------
K
I
K
P
Q
--
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
-
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
--------
Y
S
H
--
T
-
H
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
--
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
---------
41
HHSearch
82.93
32%
-78
* C2 *
2PAN
5
GCL_ECOLI
A:
[25-584]
--------------------------------
A
K
M
R
A
V
D
A
A
M
Y
V
L
E
K
E
G
I
T
T
A
F
G
V
P
G
A
A
I
N
P
F
Y
S
A
M
R
--
K
-
H
G
G
I
R
H
I
L
A
R
H
V
E
G
A
S
H
M
A
E
G
Y
T
R
A
T
A
G
N
I
G
V
C
L
G
T
S
G
P
A
G
T
D
M
I
T
A
L
Y
S
A
S
A
D
S
I
P
I
L
C
I
T
G
Q
A
P
R
A
R
L
H
K
E
D
F
Q
A
V
D
I
E
A
I
A
K
P
V
S
K
M
A
V
T
V
R
E
A
A
L
V
P
R
V
L
Q
Q
A
F
H
L
M
R
S
G
R
P
G
P
V
L
V
D
L
P
F
D
V
Q
V
A
E
I
E
F
-
D
P
D
M
Y
E
P
L
P
V
Y
--------
K
P
A
A
S
R
M
Q
I
E
K
A
V
E
M
L
I
Q
A
E
R
P
V
I
V
A
G
G
G
V
-
I
N
-
A
D
A
A
A
L
L
Q
Q
F
A
E
L
T
S
V
P
V
I
P
T
L
M
G
W
G
C
I
P
--
D
D
-
H
E
L
M
A
G
M
V
G
L
Q
T
A
H
R
Y
-
G
N
A
T
L
L
A
S
D
M
V
F
G
I
G
N
R
F
A
N
R
H
T
G
S
V
E
K
Y
T
E
---------
G
R
--
K
I
V
H
I
D
I
E
P
T
Q
I
G
R
V
L
C
P
D
L
G
I
V
S
D
A
K
A
A
L
T
L
L
V
E
V
A
Q
E
M
Q
K
A
GRL
P
---
C
------
R
K
E
W
V
A
D
C
Q
Q
R
K
R
T
L
L
R
K
T
H
--
F
D
N
-
V
-------
P
V
K
P
Q
--
R
V
Y
E
E
M
N
K
A
F
G
R
---
D
V
C
Y
V
T
T
I
G
L
S
Q
I
A
A
A
Q
-
M
L
H
V
F
K
D
R
H
W
I
N
C
G
Q
A
G
P
L
G
W
T
I
P
A
A
L
G
V
C
A
A
D
P
K
R
N
V
V
A
I
S
G
D
F
D
F
Q
F
L
I
E
E
L
A
V
G
A
Q
F
N
I
P
Y
I
H
V
L
V
N
N
A
Y
L
G
L
I
R
Q
S
Q
R
A
F
---------
D
M
D
Y
CVQLAFEN
I
N
S
SE
V
N
-
G
Y
G
V
D
H
V
K
V
A
E
G
L
G
C
K
A
I
R
V
F
K
P
E
D
I
A
P
A
F
E
--
Q
A
K
A
L
M
A
Q
Y
R
V
P
V
V
V
E
V
I
L
E
R
V
T
N
I
----------------
7
PsiBlast_PDB
82.42
32%
-84
- C2 -
2PAN
5
GCL_ECOLI
A:
[37-576]
--------------------------------------------
L
E
K
E
G
I
T
T
A
F
G
V
P
G
A
A
I
N
P
F
Y
S
A
M
R
--
K
H
G
-
G
I
R
H
I
L
A
R
H
V
E
G
A
S
H
M
A
E
G
Y
T
R
A
T
A
G
N
I
G
V
C
L
G
T
S
G
P
A
G
T
D
M
I
T
A
L
Y
S
A
S
A
D
S
I
P
I
L
C
I
T
G
Q
A
P
R
A
R
L
H
K
E
D
F
Q
A
V
D
I
E
A
I
A
K
P
V
S
K
M
A
V
T
V
R
E
A
A
L
V
P
R
V
L
Q
Q
A
F
H
L
M
R
S
G
R
P
G
P
V
L
V
D
L
P
F
D
V
Q
V
A
E
I
E
F
-
D
P
D
M
Y
E
P
L
P
V
Y
------
K
P
A
A
--
S
R
M
Q
I
E
K
A
V
E
M
L
I
Q
A
E
R
P
V
I
V
A
G
G
G
V
-
I
N
-
A
D
A
A
A
L
L
Q
Q
F
A
E
L
T
S
V
P
V
I
P
T
L
M
G
W
G
C
I
P
--
D
D
-
H
E
L
M
A
G
M
V
G
L
Q
T
-
A
H
R
Y
G
N
A
T
L
L
A
S
D
M
V
F
G
I
G
N
R
F
A
N
R
H
T
G
S
V
E
K
Y
T
E
---------
G
R
--
K
I
V
H
I
D
I
E
P
T
Q
I
G
R
V
L
C
P
D
L
G
I
V
S
D
A
K
A
A
L
T
L
L
V
E
V
A
Q
E
M
------
Q
---
K
A
GRLPC
R
K
E
W
V
A
D
C
Q
Q
R
K
R
T
L
-
L
R
K
T
-
H
F
D
N
-
V
-------
P
V
K
P
Q
--
R
V
Y
E
E
M
N
K
A
F
G
R
---
D
V
C
Y
V
T
T
I
G
L
S
Q
I
A
A
A
Q
M
L
H
V
F
K
D
R
-
H
W
I
N
C
G
Q
A
G
P
L
G
W
T
I
P
A
A
L
G
V
C
A
A
D
P
K
R
N
V
V
A
I
S
G
D
F
D
F
Q
F
L
I
E
E
L
A
V
G
A
Q
F
N
I
P
Y
I
H
V
L
V
N
N
A
Y
L
G
L
I
R
Q
S
Q
R
A
F
DMDYCVQLA
F
E
N
I
--------
N
S
S
--
E
V
N
G
Y
G
V
D
H
V
K
V
A
E
G
L
G
C
K
A
I
R
V
F
K
P
E
D
I
A
P
A
F
E
--
Q
A
K
A
L
M
A
Q
Y
R
V
P
V
V
V
E
V
------------------------
45
HHSearch
78.53
25%
-88
- C2 -
3EYA
11
POXB_ECOLI
A:
[2-538]
---------------------------------
K
Q
T
V
A
A
Y
I
A
K
T
L
E
S
A
G
V
K
R
I
W
G
V
T
G
D
S
L
N
G
L
S
D
S
L
N
--
R
-
M
G
T
I
E
W
M
S
T
R
H
E
E
V
A
A
F
A
A
G
A
E
A
Q
L
S
-
G
E
L
A
V
C
A
G
S
C
G
P
G
N
L
H
L
I
N
G
L
F
D
C
H
R
N
H
V
P
V
L
A
I
A
A
H
I
P
S
S
E
I
G
S
G
Y
F
Q
E
T
H
P
Q
E
L
F
R
E
C
S
H
Y
C
E
L
V
S
S
P
E
Q
I
P
Q
V
L
A
I
A
M
R
K
A
V
L
N
R
-
G
V
S
V
V
V
L
P
G
D
V
A
L
K
P
A
P
E
-
G
A
T
M
H
-
W
Y
H
A
P
------
Q
P
V
V
T
P
E
E
E
E
L
R
K
L
A
Q
L
L
R
Y
S
S
N
I
A
L
M
C
G
S
G
C
-
A
G
---
A
H
K
E
L
V
E
F
A
G
K
I
K
A
P
I
V
H
A
L
R
G
K
E
H
V
E
--
Y
D
-
N
P
Y
D
V
G
M
T
G
L
I
G
-
F
S
S
-
G
F
H
T
M
M
N
A
D
T
L
V
L
L
G
T
Q
F
P
Y
R
A
F
-----
Y
P
T
---------
D
A
--
K
I
I
Q
I
D
I
N
P
A
S
I
G
A
H
S
K
V
D
M
A
L
V
G
D
I
K
S
T
L
R
A
L
L
P
L
V
E
E
K
------
A
DR
K
F
------
L
D
K
A
L
E
D
Y
R
D
A
R
K
G
L
D
D
L
A
K
--
P
S
E
-
K
-------
A
I
H
P
Q
--
Y
L
A
Q
Q
I
S
H
F
A
A
D
---
D
A
I
F
T
C
D
V
G
T
P
T
V
W
A
A
R
-
Y
L
K
M
N
G
K
R
R
L
L
G
S
F
N
H
G
S
M
A
N
A
M
P
Q
A
L
G
A
Q
A
T
E
P
E
R
Q
V
V
A
M
C
G
D
G
G
F
S
M
L
M
G
D
F
L
S
V
V
Q
M
K
L
P
V
K
I
V
V
F
N
N
S
V
L
G
F
V
------------------------------
G
--
T
E
-
L
H
D
T
N
F
A
R
I
A
E
A
C
G
I
T
G
I
R
V
E
K
A
S
E
V
D
E
A
L
Q
--
R
A
F
S
----
I
D
G
P
V
L
V
D
V
V
V
A
K
E
E
L
A
I
P
P
Q
I
-----------
10
PsiBlast_PDB
77.07
27%
-83
- C2 -
4RJI
3
?
A:
[15-545]
---------------------------------
N
R
-
G
A
E
L
V
V
D
C
L
V
E
Q
G
V
T
H
V
F
G
I
P
G
A
K
I
D
A
V
F
D
A
L
Q
--
D
-
K
-
G
P
E
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
V
G
R
L
T
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
S
N
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
L
K
R
T
H
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
K
N
I
P
E
A
V
T
N
A
F
R
I
A
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
E
V
T
N
T
-
K
N
V
R
A
V
A
A
P
K
---------
L
G
P
A
A
D
D
A
I
S
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
K
G
-
G
R
-
P
E
A
I
K
A
V
R
K
L
L
K
K
V
Q
L
P
F
V
E
T
Y
Q
A
A
G
T
L
S
RD
L
E
-
D
Q
Y
F
-
G
R
I
G
L
F
R
-
N
Q
P
-
G
D
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
---
D
P
I
E
Y
D
P
K
F
W
N
I
---------
N
G
D
R
T
I
I
H
L
D
E
I
I
A
D
I
D
H
A
Y
Q
P
D
L
E
L
I
G
D
I
P
S
T
I
N
H
I
E
H
D
A
V
K
-------
V
---
E
------
F
A
E
R
E
Q
K
I
L
S
D
L
K
Q
Y
---
M
H
-
E
G
E
---SD-----
R
A
H
P
L
--
E
I
V
K
E
L
R
N
A
V
D
D
---
H
V
T
V
T
C
D
I
G
S
H
A
I
W
M
S
R
-
Y
F
R
S
Y
E
P
L
T
L
M
I
S
N
G
M
Q
T
L
G
V
A
L
P
W
A
I
G
A
S
L
V
K
P
G
E
K
V
V
S
V
S
G
D
G
G
F
L
F
S
A
M
E
L
E
T
A
V
R
L
K
A
P
I
V
H
I
V
W
N
D
S
T
Y
D
M
V
A
F
Q
Q
L
K
K
---------
Y
N
R
----------
T
S
--
A
V
D
F
G
N
I
D
I
V
K
Y
A
E
S
F
G
A
T
G
L
R
V
E
S
P
D
Q
L
A
D
V
L
R
--
Q
G
M
N
----
A
E
G
P
V
I
I
D
V
P
V
----------------------
15
PsiBlast_PDB
77.03
28%
-76
- C2 -
4FEE
9
?
A:
[17-545]
----------------------------------------
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
-
D
-
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
-
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
-
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
P
A
E
D
W
Y
A
S
A
N
S
Y
Q
T
------
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
-
R
---
K
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
--
D
R
-
Y
P
A
Y
L
G
S
A
N
R
V
A
-
Q
K
P
-
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
E
V
S
K
--
A
F
K
N
---------
T
R
--
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
E
R
------
E
---
S
------
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
-
L
E
D
K
-
Q
-------
E
G
P
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
---
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
-
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
T
---------
N
Q
N
D
--------
F
I
G
--
V
E
F
N
-
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
----
Q
H
E
P
V
L
I
D
A
V
I
T
---------------------
11
PsiBlast_PDB
77.01
27%
-83
- C2 -
4RJJ
7
?
A:
[14-545]
--------------------------------
K
N
R
-
G
A
E
L
V
V
D
C
L
V
E
Q
G
V
T
H
V
F
G
I
P
G
A
K
I
D
A
V
F
D
A
L
Q
--
D
-
K
-
G
P
E
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
V
G
R
L
T
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
S
N
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
L
K
R
T
H
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
K
N
I
P
E
A
V
T
N
A
F
R
I
A
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
E
V
T
N
T
-
K
N
V
R
A
V
A
A
P
K
---------
L
G
P
A
A
D
D
A
I
S
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
K
G
-
G
R
-
P
E
A
I
K
A
V
R
K
L
L
K
K
V
Q
L
P
F
V
E
T
Y
Q
A
A
G
T
L
S
--
R
D
L
E
D
Q
Y
F
G
R
I
G
L
F
R
-
N
Q
P
-
G
D
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
---
D
P
I
E
Y
D
P
K
F
W
N
I
---------
N
G
D
R
T
I
I
H
L
D
E
I
I
A
D
I
D
H
A
Y
Q
P
D
L
E
L
I
G
D
I
P
S
T
I
N
H
I
E
H
D
A
V
K
-------
V
---
E
------
F
A
E
R
E
Q
K
I
L
S
D
L
K
Q
Y
---
M
H
-
E
G
E
Q
-
V
PADWKSD
R
A
H
P
L
--
E
I
V
K
E
L
R
N
A
V
D
D
---
H
V
T
V
T
C
D
I
G
S
H
A
I
W
M
S
R
-
Y
F
R
S
Y
E
P
L
T
L
M
I
S
N
G
M
Q
T
L
G
V
A
L
P
W
A
I
G
A
S
L
V
K
P
G
E
K
V
V
S
V
S
G
D
G
G
F
L
F
S
A
M
E
L
E
T
A
V
R
L
K
A
P
I
V
H
I
V
W
N
D
S
T
Y
D
M
V
A
F
Q
Q
L
K
K
---------
Y
N
R
----------
T
S
--
A
V
D
F
G
N
I
D
I
V
K
Y
A
E
S
F
G
A
T
G
L
R
V
E
S
P
D
Q
L
A
D
V
L
R
--
Q
G
M
N
----
A
E
G
P
V
I
I
D
V
P
V
----------------------