@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1874: (2016-03-29 )
MSDKYYRSAYMNVDLNAVASNFKVFSTLHPNKTVMAVVKANAYGLGSVKVARHLMENGATFFAVATLDEAIELRMHGITAKILVLGVLPAKDIDKAIQHRVALTVPSKQWLKEAIKNISGEQEKKLWLHIKLDTGMGRLGIKDTNTYQEVIEIIQQYEQLVFEGVFTHFACADEPGDMTTEQYQRFKDMVNEAIKPEYIHCQNSAGSLLMDCQFCNAIRPGISLYGYYPSEYVQQKVKVHLKPSVQLIANVVQTKTLQAGESVSYGATYTATDPTTIALLPIGYADGYLRIMQGSFVNVNGHQCEVIGRVCMDQTIVKVPDQVKAGDSVILIDNHRESPQSVEVVAEKQHTINYEVLCNLSRRLPRIYHDGDQRFVTNELLK
Atome Classification :
(27 SA)
.........10----.-.......20..-....-..30...-..-....40........50........60........70........80.-.......90........100.......110.......120--.......130.......140-...-.-...150---...-..---..160.......170..-.-.-.-..180--.-........---190----.----.-.----....200.......210--..--.--....-.220.......230....-...240.......250.......260.......270.......280.......290.-...-...300.......310.......---320-.---.......330.......340.......350.......360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSD
K
Y
Y
R
S
A
Y
M
----
N
-
V
D
L
N
A
VASN
F
K
-
V
F
S
T
-LHP-N
K
T
-
V
M
-
A
V
V
KANAYGL
G
S
V
K
V
A
R
H
L
M
ENG
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
MHG
I
T
A
K
I
-
L
V
L
GVL
P
A
K
D
I
D
K
A
I
Q
H
R
V
A
L
TV
P
S
K
Q
W
L
K
E
A
I
K
NISGEQ--
E
K
K
L
W
L
H
I
K
L
DTGMGRLGIK-DTN-
T
-
Y
Q
E
V
I
E
---
I
I
Q
-
Q
Y
---
E
Q
L
V
F
E
G
V
F
T
H
FACADE-P-G-D-M
T
T
----
E
-
Q
Y
Q
R
F
K
D
M
---
V
N
E----A----I-K----P
E
Y
I
H
CQNSAG
S
L
L
M
D
---
C
Q
--
F
--
C
N
AI-RPG
I
S
L
Y
GYY
P
S
E
Y
V
Q
Q
K
-
V
K
V
HLK
P
S
V
Q
L
I
A
N
V
V
Q
T
K
TLQAGESVSYG
A
T
Y
TATD
P
T
T
I
A
L
L
PIGYADG
Y
L
R
I
MQ-G
S
F
-
V
NVNG
H
Q
C
E
V
I
G
R
V
CM
D
Q
T
I
V
KV---PD--Q---VKAG
D
S
V
I
L
IDNHRESP
Q
S
V
E
V
V
A
EKQHTI
N
Y
E
V
L
C
N
L
S
R
RL
P
R
I
YHDGDQ
R
F
V
T
N
E
LLK
2
PsiBlast_PDB
99.21
99%
-129
- C1 -
3OO2
3
ALR1_STAAC
A:
[5-385]
-
S
D
K
Y
Y
R
S
A
Y
M
----
N
-
V
D
L
N
A
V
A
S
N
F
K
-
V
F
S
T
-
L
H
P
-
N
K
T
-
V
M
-
A
V
V
K
A
N
A
Y
G
L
G
S
V
K
V
A
R
H
L
M
E
N
G
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
M
H
G
I
T
A
K
I
-
L
V
L
G
V
L
P
A
K
D
I
D
K
A
I
Q
H
R
V
A
L
T
V
P
S
K
Q
W
L
K
E
A
I
K
N
I
S
G
E
Q
--
E
K
K
L
W
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
-
D
T
K
-
T
-
Y
Q
E
V
I
E
---
I
I
Q
-
Q
Y
---
E
Q
L
V
F
E
G
V
F
T
H
F
A
C
A
D
E
-
P
-
G
-
D
-
M
T
T
----
E
-
Q
Y
Q
R
F
K
D
M
---
V
N
E
----
A
----
I
-
K
----
P
E
Y
I
H
C
Q
N
S
A
G
S
L
L
M
D
---
C
Q
--
F
--
C
N
A
I
-
R
P
G
I
S
L
Y
G
Y
Y
P
S
E
Y
V
Q
Q
K
-
V
K
V
H
L
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
L
Q
A
G
E
S
V
S
Y
G
--
Y
T
A
T
D
P
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
-
G
S
F
-
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
I
V
K
V
---
P
D
--
Q
---
V
K
A
G
D
S
V
I
L
I
D
N
H
R
E
S
P
Q
S
V
E
V
V
A
E
K
Q
H
T
I
N
Y
E
V
L
C
N
L
S
R
R
L
P
R
I
Y
H
D
G
D
Q
R
F
V
T
N
E
L
L
K
22
PsiBlast_CBE
94.12
99%
-126
- C1 -
3OO2
3
ALR1_STAAC
B:
[5-385]
-
S
D
K
Y
Y
R
S
A
Y
M
----
N
-
V
D
L
N
A
V
A
S
N
F
K
-
V
F
S
T
-
L
H
P
-
N
K
T
-
V
M
-
A
V
V
K
A
N
A
Y
G
L
G
S
V
K
V
A
R
H
L
M
E
N
G
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
M
H
G
I
T
A
K
I
-
L
V
L
G
V
L
P
A
K
D
I
D
K
A
I
Q
H
R
V
A
L
T
V
P
S
K
Q
W
L
K
E
A
I
K
N
I
S
------
K
K
L
W
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
-
D
T
K
-
T
-
Y
Q
E
V
I
E
---
I
I
Q
-
Q
Y
---
E
Q
L
V
F
E
G
V
F
T
H
F
A
C
A
D
E
-
P
-
G
-
D
-
M
T
T
----
E
-
Q
Y
Q
R
F
K
D
M
---
V
N
E
----
A
----
I
-
K
----
P
E
Y
I
H
C
Q
N
S
A
G
S
L
L
M
D
---
C
Q
--
F
--
C
N
A
I
-
R
P
G
I
S
L
Y
G
Y
Y
P
S
E
Y
V
Q
Q
K
-
V
K
V
H
L
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
L
Q
A
-------------
D
P
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
-
G
S
F
-
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
I
V
K
V
---
P
D
--
Q
---
V
K
A
G
D
S
V
I
L
I
D
N
H
R
E
S
P
Q
S
V
E
V
V
A
E
K
Q
H
T
I
N
Y
E
V
L
C
N
L
S
R
R
L
P
R
I
Y
H
D
G
D
Q
R
F
V
T
N
E
L
L
K
21
PsiBlast_CBE
93.40
100%
-129
- C1 -
4A3Q
11
ALR1_STAAM
B:
[2-382]
-
S
D
K
Y
Y
R
S
A
Y
M
----
N
-
V
D
L
N
A
V
A
S
N
F
K
-
V
F
S
T
-
L
H
P
-
N
K
T
-
V
M
-
A
V
V
K
A
N
A
Y
G
L
G
S
V
K
V
A
R
H
L
M
E
N
G
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
M
H
G
I
T
A
K
I
-
L
V
L
G
V
L
P
A
K
D
I
D
K
A
I
Q
H
R
V
A
L
T
V
P
S
K
Q
W
L
K
E
A
I
K
N
I
S
G
E
Q
--
E
K
K
L
W
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
-
D
T
N
-
T
-
Y
Q
E
V
I
E
---
I
I
Q
-
Q
Y
---
E
Q
L
V
F
E
G
V
F
T
H
F
-------------
T
T
----
E
-
Q
Y
Q
R
F
K
D
M
---
V
N
E
----
A
----
I
-
K
----
P
E
Y
I
H
C
Q
N
S
A
G
S
L
L
M
D
---
C
Q
--
F
--
C
N
A
I
-
R
P
G
I
S
L
Y
G
Y
Y
P
S
E
Y
V
Q
Q
K
-
V
K
V
H
L
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
L
----------------
P
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
-
G
S
F
-
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
I
V
K
V
---
P
D
--
Q
---
V
K
A
G
D
S
V
I
L
I
D
N
H
R
E
S
P
Q
S
V
E
V
V
A
E
K
Q
H
T
I
N
Y
E
V
L
C
N
L
S
R
R
L
P
R
I
Y
H
D
G
D
Q
R
F
V
T
N
E
L
L
K
1
PsiBlast_PDB
92.35
100%
-128
- C1 -
4A3Q
10
ALR1_STAAM
A:
[2-382]
-
S
D
K
Y
Y
R
S
A
Y
M
----
N
-
V
D
L
N
A
V
A
S
N
F
K
-
V
F
S
T
-
L
H
P
-
N
K
T
-
V
M
-
A
V
V
K
A
N
A
Y
G
L
G
S
V
K
V
A
R
H
L
M
E
N
G
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
M
H
G
I
T
A
K
I
-
L
V
L
G
V
L
P
A
K
D
I
D
K
A
I
Q
H
R
V
A
L
T
V
P
S
K
Q
W
L
K
E
A
I
K
N
I
S
G
E
Q
--
E
K
K
L
W
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
-
D
T
N
-
T
-
Y
Q
E
V
I
E
---
I
I
Q
-
Q
Y
---
E
Q
L
V
F
E
G
V
F
T
H
F
----------
D
-
M
T
T
----
E
-
Q
Y
Q
R
F
K
D
M
---
V
N
E
----
A
----
I
-
K
----
P
E
Y
I
H
C
Q
N
S
A
G
S
L
L
M
D
---
C
Q
--
F
--
C
N
A
I
-
R
P
G
I
S
L
Y
G
Y
Y
P
S
E
Y
V
Q
Q
K
-
V
K
V
H
L
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
------------------
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
-
G
S
F
-
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
I
V
K
V
---
P
D
--
Q
---
V
K
A
G
D
S
V
I
L
I
D
N
H
R
E
S
P
Q
S
V
E
V
V
A
E
K
Q
H
T
I
N
Y
E
V
L
C
N
L
S
R
R
L
P
R
I
Y
H
D
G
D
Q
R
F
V
T
N
E
L
L
K
23
PsiBlast_CBE
78.19
43%
-114
- C1 -
1SFT
3
ALR_GEOSE
B:
[2-368]
--
N
D
F
H
R
D
T
W
A
----
E
-
V
D
L
D
A
I
Y
D
N
V
E
-
N
L
R
R
-
L
L
P
-
D
D
T
H
I
M
-
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
-
L
V
L
G
A
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
E
A
S
A
L
Y
S
G
P
----
F
P
I
H
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
-
D
E
E
-
E
-
T
K
R
I
V
A
---
L
I
E
-
R
H
---
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
-
V
-
N
T
D
-
Y
F
S
----
Y
-
Q
Y
T
R
F
L
H
M
---
L
E
W
L---
P
----
S
-
R
----
P
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
---
D
R
--
T
--
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
-
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
-
H
F
H
-
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
---
P
G
--
P
---
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
--------------
24
PsiBlast_CBE
77.65
43%
-114
- C1 -
1BD0
2
ALR_GEOSE
B:
[2-368]
--
N
D
F
H
R
D
T
W
A
----
E
-
V
D
L
D
A
I
Y
D
N
V
E
-
N
L
R
R
-
L
L
P
-
D
D
T
H
I
M
-
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
-
L
V
L
G
A
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
E
A
S
A
L
Y
S
G
P
----
F
P
I
H
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
-
D
E
E
-
E
-
T
K
R
I
V
A
---
L
I
E
-
R
H
---
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
-
V
-
N
T
D
-
Y
F
S
----
Y
-
Q
Y
T
R
F
L
H
M
---
L
E
W
L---
P
----
S
-
R
----
P
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
---
D
R
--
T
--
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
-
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
-
H
F
H
-
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
---
P
G
--
P
---
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
--------------
3
PsiBlast_PDB
77.10
43%
-114
- C1 -
1SFT
3
ALR_GEOSE
A:
[2-368]
--
N
D
F
H
R
D
T
W
A
----
E
-
V
D
L
D
A
I
Y
D
N
V
E
-
N
L
R
R
-
L
L
P
-
D
D
T
H
I
M
-
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
-
L
V
L
G
A
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
E
A
S
A
L
Y
S
G
P
----
F
P
I
H
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
-
D
E
E
-
E
-
T
K
R
I
V
A
---
L
I
E
-
R
H
---
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
-
V
-
N
T
D
-
Y
F
S
----
Y
-
Q
Y
T
R
F
L
H
M
---
L
E
W
L---
P
----
S
-
R
----
P
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
---
D
R
--
T
--
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
-
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
-
H
F
H
-
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
---
P
G
--
P
---
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
--------------
4
PsiBlast_PDB
76.56
43%
-111
- C1 -
1BD0
2
ALR_GEOSE
A:
[2-368]
--
N
D
F
H
R
D
T
W
A
----
E
-
V
D
L
D
A
I
Y
D
N
V
E
-
N
L
R
R
-
L
L
P
-
D
D
T
H
I
M
-
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
-
L
V
L
G
A
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
E
A
S
A
L
Y
S
G
P
----
F
P
I
H
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
-
D
E
E
-
E
-
T
K
R
I
V
A
---
L
I
E
-
R
H
---
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
-
V
-
N
T
D
-
Y
F
S
----
Y
-
Q
Y
T
R
F
L
H
M
---
L
E
W
L---
P
----
S
-
R
----
P
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
---
D
R
--
T
--
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
-
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
-
H
F
H
-
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
---
P
G
--
P
---
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
--------------
66
HHSearch
75.36
43%
-111
- C1 -
1BD0
2
ALR_GEOSE
A:
[4-376]
-----
F
H
R
D
T
W
----
A
E
V
D
L
D
A
I
Y
D
N
V
E
-
N
L
R
R
-
L
L
P
D
D
T
H
-
I
M
-
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
-
L
V
L
G
A
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
E
A
S
A
L
Y
--
S
G
--
P
F
P
I
H
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
-
D
-
E
-
E
E
T
K
R
I
V
A
---
L
I
E
-
R
H
---
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
-
V
-
N
T
D
-
Y
F
S
----
Y
-
Q
Y
T
R
F
L
H
M
---
L
E
W
----
L
----
P
S
R
----
P
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
---
D
R
--
T
--
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
-
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
-
H
F
H
-
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
---
P
G
--
P
---
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
F
R
H
K
R
I
M
E
------
8
PsiBlast_PDB
75.32
39%
-109
- C1 -
3HA1
3
?
A:
[6-373]
----
F
Y
R
D
T
W
V
----
E
-
V
D
L
D
A
I
Y
N
N
V
T
-
H
I
K
E
-
F
I
P
-
S
D
V
E
I
F
-
A
V
V
K
G
N
A
Y
G
H
D
Y
V
P
V
A
K
I
A
L
E
A
G
A
T
R
L
A
V
A
F
L
D
E
A
L
V
L
R
R
A
G
I
T
A
P
I
-
L
V
L
G
P
S
P
P
R
D
I
N
V
A
A
E
N
D
V
A
L
T
V
F
Q
K
E
W
V
D
E
A
I
K
L
W
D
G
S
S
--
T
M
K
Y
--
H
I
N
F
D
S
G
M
G
R
I
G
I
R
-
E
R
K
-
E
-
L
K
G
F
L
K
---
S
L
E
-
G
A
---
P
F
L
E
L
E
G
V
Y
T
H
F
A
T
A
D
E
V
E
-
T
-
S
-
Y
F
D
----
K
-
Q
Y
N
T
F
L
E
Q
---
L
S
W
L
K
E
F
G
----
V
-
D
----
P
K
F
V
H
T
A
N
S
A
A
T
L
R
F
Q
---
G
I
--
T
--
F
N
A
V
-
R
I
G
I
A
M
Y
G
L
S
P
S
V
E
I
R
P
F
-
L
P
F
K
L
E
P
A
L
S
L
H
T
K
V
A
H
I
K
Q
V
I
K
G
D
G
I
S
Y
N
V
T
Y
R
T
K
T
E
E
W
I
A
T
V
A
I
G
Y
A
D
G
W
L
R
R
L
Q
-
G
F
E
-
V
L
V
N
G
K
R
V
P
I
V
G
R
V
T
M
D
Q
F
M
I
H
L
---
P
C
--
E
---
V
P
L
G
T
K
V
T
L
I
G
R
Q
G
D
E
Y
I
S
A
T
E
V
A
E
Y
S
G
T
I
N
Y
E
I
I
T
T
I
S
F
R
V
P
R
I
F
--------------
7
PsiBlast_PDB
74.25
40%
-128
- C1 -
4ILS
-
ALR_GEOSE
A:
[2-368]
--
N
D
F
H
R
D
T
W
A
----
E
-
V
D
L
D
A
I
Y
D
N
V
E
-
N
L
R
R
-
L
L
P
-
D
D
T
H
I
M
-
A
S
V
C
G
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
-
L
V
T
G
A
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
E
A
S
A
L
Y
S
G
P
----
F
P
I
H
F
H
L
Y
M
D
T
G
M
G
---
V
K
-
D
E
E
-
E
-
T
K
R
I
V
A
---
L
I
E
-
R
H
---
P
H
F
V
L
E
G
L
W
T
W
F
-------------------
Y
-
Q
Y
T
R
F
L
H
M
---
L
E
W
L---
P
----
S
-
R
----
P
P
L
V
F
C
A
N
---
S
L
R
------
R
--
T
--
F
N
M
V
-
Q
F
G
I
A
M
Y
G
L
A
-----------
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
K
D
G
W
L
R
R
L
Q
-
H
F
H
-
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
L
M
D
M
C
M
I
R
L
---
P
G
--
P
---
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
K
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
--------------
28
PsiBlast_CBE
71.91
38%
-107
- C1 -
3E5P
2
?
B:
[5-371]
----
W
H
R
P
T
R
L
----
H
-
I
D
T
Q
A
I
T
E
N
V
Q
-
K
E
C
Q
-
R
L
P
-
E
G
T
-
A
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
-
L
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
A
A
L
Q
Q
L
T
P
E
S
--
N
T
P
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
-
T
P
E
-
E
-
T
K
Q
A
V
R
---
F
V
Q
-
S
H
---
K
E
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
-
I
-
D
-
T
-
S
Y
F
----
E
K
Q
A
G
R
F
K
A
V
L
A
-
V
L
E
----
E
----
L
------
P
R
Y
V
H
V
S
N
S
A
T
A
L
W
H
P
---
D
V
--
P
--
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
S
G
N
-
K
L
A
-
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
F
T
-
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
--
E
---
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
N
-------------
10
PsiBlast_PDB
71.88
36%
-114
- C1 -
4LUT
2
?
A:
[9-383]
---------
W
A
----
E
-
I
N
L
D
N
L
R
F
N
L
N
N
I
K
N
L
-
L
E
E
-
D
I
K
-
I
C
-
G
V
I
K
A
D
A
Y
G
H
G
A
V
E
V
A
K
L
L
E
K
E
K
V
D
Y
L
A
V
A
R
T
A
E
G
I
E
L
R
Q
N
G
I
T
L
P
I
-
L
N
L
G
Y
T
P
D
E
A
F
E
D
S
I
K
N
K
I
T
M
T
V
Y
S
L
E
T
A
Q
K
-
I
N
E
I
A
K
S
L
--
G
E
K
A
C
V
H
V
K
I
D
-------
F
Q
P
N
E
E
-
S
-
V
Q
E
I
I
E
---
L
-
N
-
K
L
---
E
Y
I
D
L
E
G
M
F
T
H
F
A
T
A
D
E
-
V
-
S
-
K
-
E
Y
T
Y
K
Q
A
N
-
N
Y
K
F
M
S
D
K
---
L
D
E
----
A
G---
V
-
K
----
I
A
I
K
H
V
S
N
S
A
A
--
I
M
D
---
C
P
DL
R
--
L
N
M
V
-
R
A
G
I
I
L
Y
G
H
Y
P
S
D
D
V
F
-
K
-
D
R
L
E
L
R
P
A
M
K
L
K
S
K
I
G
H
I
K
Q
V
E
P
G
V
G
I
S
Y
G
L
K
Y
T
T
T
G
K
E
T
I
A
T
V
P
I
G
Y
A
D
G
F
T
R
I
Q
K
-
N
P
K
-
V
L
I
K
G
E
V
F
D
V
V
G
R
I
C
M
D
Q
I
M
V
R
I
---
D
K
D
I
D
---
I
K
V
G
D
E
V
I
L
F
G
---
E
G
E
V
T
A
E
R
I
A
K
D
L
G
T
I
N
Y
E
V
L
C
M
I
S
R
R
V
D
R
V
Y
M
E
N
N
E
L
V
Q
I
N
S
Y
L
-
11
PsiBlast_PDB
71.77
36%
-116
- C1 -
4LUS
1
?
B:
[9-383]
---------
W
A
----
E
-
I
N
L
D
N
L
R
F
N
L
N
N
I
K
N
L
-
L
E
E
-
D
I
K
-
I
C
-
G
V
I
K
A
D
A
Y
G
H
G
A
V
E
V
A
K
L
L
E
K
E
K
V
D
Y
L
A
V
A
R
T
A
E
G
I
E
L
R
Q
N
G
I
T
L
P
I
-
L
N
L
G
Y
T
P
D
E
A
F
E
D
S
I
K
N
K
I
T
M
T
V
Y
S
L
E
T
A
Q
K
-
I
N
E
I
A
K
S
L
--
G
E
K
A
C
V
H
V
K
I
D
S
-----
G
F
Q
P
N
E
E
-
S
-
V
Q
E
I
I
E
---
L
-
N
-
K
L
---
E
Y
I
D
L
E
G
M
F
T
H
F
A
T
A
D
E
-------
E
Y
T
Y
K
Q
A
N
-
N
Y
K
F
M
S
D
K
---
L
D
E
----
A
G---
V
-
K
----
I
A
I
K
H
V
S
N
S
A
A
--
I
M
D
---
C
P
DL
R
--
L
N
M
V
-
R
A
G
I
I
L
Y
G
H
Y
P
S
D
D
V
F
-
K
-
D
R
L
E
L
R
P
A
M
K
L
K
S
K
I
G
H
I
K
Q
V
E
P
G
V
G
I
S
Y
G
L
K
Y
T
T
T
G
K
E
T
I
A
T
V
P
I
G
Y
A
D
G
F
T
R
I
Q
K
-
N
P
K
-
V
L
I
K
G
E
V
F
D
V
V
G
R
I
C
M
D
Q
I
M
V
R
I
---
D
K
DI
D
---
I
K
V
G
D
E
V
I
L
F
G
---
E
G
E
V
T
A
E
R
I
A
K
D
L
G
T
I
N
Y
E
V
L
C
M
I
S
R
R
V
D
R
V
Y
M
E
N
N
E
L
V
Q
I
N
S
Y
L
-
25
PsiBlast_CBE
71.42
38%
-109
- C1 -
3E6E
2
?
C:
[5-371]
----
W
H
R
P
T
R
L
----
H
-
I
D
T
Q
A
I
T
E
N
V
Q
-
K
E
C
Q
-
R
L
P
-
E
G
T
-
A
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
-
L
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
A
A
L
Q
Q
L
T
P
E
S
--
N
T
P
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
-
T
P
E
-
E
-
T
K
Q
A
V
R
---
F
V
Q
-
S
H
---
K
E
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
-
I
-
D
-
T
-
S
Y
F
----
E
K
Q
A
G
R
F
K
A
V
LA-
V
L
E
----
E
----
L
------
P
R
Y
V
H
V
S
N
S
A
T
A
L
W
H
P
---
D
V
--
P
--
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
S
G
N
-
K
L
A
-
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
F
T
-
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
--
E
---
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
N
-------------
27
PsiBlast_CBE
70.99
38%
-106
- C1 -
3E5P
6
?
C:
[5-371]
----
W
H
R
P
T
R
L
----
H
-
I
D
T
Q
A
I
T
E
N
V
Q
-
K
E
C
Q
-
R
L
P
-
E
G
T
-
A
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
-
L
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
A
A
L
Q
Q
L
T
P
E
S
--
N
T
P
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
-
T
P
E
-
E
-
T
K
Q
A
V
R
---
F
V
Q
-
S
H
---
K
E
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
-
I
-
D
-
T
-
S
Y
F
----
E
K
Q
A
G
R
F
K
A
V
LA-
V
L
E
----
E
----
L
------
P
R
Y
V
H
V
S
N
S
A
T
A
L
W
H
P
---
D
V
--
P
--
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
S
G
N
-
K
L
A
-
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
F
T
-
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
--
E
---
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
N
-------------
13
PsiBlast_PDB
70.79
32%
-112
- C1 -
1XFC
1
ALR_MYCTU
A:
[16-381]
-----------------
V
D
L
G
A
I
E
H
N
V
R
-
V
L
R
E
-
H
A
G
-
H
A
Q
-
L
M
-
A
V
V
K
A
D
G
Y
G
H
G
A
T
R
V
A
Q
T
A
L
G
A
G
A
A
E
L
G
V
A
T
V
D
E
A
L
A
L
R
A
D
G
I
T
A
P
V
-
L
A
W
L
H
P
P
G
I
D
F
G
P
A
L
L
A
D
V
Q
V
A
V
S
S
L
R
Q
L
D
E
L
L
H
A
V
R
-
R
T
--
G
R
T
A
T
V
T
V
K
V
D
T
G
L
N
R
N
G
V
G
-
P
A
Q
---
F
P
A
M
L
T
---
A
L
R
-
Q
A
M
A
E
D
A
V
R
L
R
G
L
M
S
H
M
------
P
-
D
-
D
-
S
I
N
----
D
V
Q
A
Q
R
F
T
A
F
---
L
A
Q
----
A
R
E
Q
G
V
-
R
----
F
E
V
A
H
L
S
N
S
S
A
T
M
A
R
P
---
D
L
--
T
--
F
D
L
V
-
R
P
G
I
A
V
Y
G
L
S
P
---
V
P
A
L
-
G
D
M
G
L
V
P
A
M
T
V
K
C
A
V
A
L
V
K
S
I
R
A
G
E
G
V
S
Y
G
H
T
W
I
A
P
R
D
T
N
L
A
L
L
P
I
G
Y
A
D
G
V
F
R
S
L
G
-
G
R
L
E
V
L
I
N
G
R
R
C
P
G
V
G
R
I
C
M
D
Q
F
M
V
D
L
GPG
P
L
--
D
---
V
A
E
G
D
E
A
I
L
F
G
P
G
I
R
G
E
P
T
A
Q
D
W
A
D
L
V
G
T
I
H
Y
E
V
V
T
S
P
R
G
R
I
T
R
T
Y
R
E
A
-----------
26
PsiBlast_CBE
70.37
38%
-109
- C1 -
3E6E
1
?
B:
[5-371]
----
W
H
R
P
T
R
L
----
H
-
I
D
T
Q
A
I
T
E
N
V
Q
-
K
E
C
Q
-
R
L
P
-
E
G
T
-
A
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
-
L
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
A
A
L
Q
Q
L
T
P
E
S
--
N
T
P
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
-
T
P
E
-
E
-
T
K
Q
A
V
R
---
F
V
Q
-
S
H
---
K
E
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
-
I
-
D
-
T
-
S
Y
F
----
E
K
Q
A
G
R
F
K
A
V
LA-
V
L
E
----
E
----
L
------
P
R
Y
V
H
V
S
N
S
A
T
A
L
W
H
P
---
D
V
--
P
--
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
S
G
N
-
K
L
A
-
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
F
T
-
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
--
E
---
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
N
-------------
5
PsiBlast_PDB
70.37
38%
-102
- C1 -
3E5P
5
?
A:
[5-371]
----
W
H
R
P
T
R
L
----
H
-
I
D
T
Q
A
I
T
E
N
V
Q
-
K
E
C
Q
-
R
L
P
-
E
G
T
-
A
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
-
L
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
A
A
L
Q
Q
L
T
P
E
S
--
N
T
P
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
-
T
P
E
-
E
-
T
K
Q
A
V
R
---
F
V
Q
-
S
H
---
K
E
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
-
I
-
D
-
T
-
S
Y
F
----
E
K
Q
A
G
R
F
K
A
V
L
A
-
V
L
E
----
E
----
L
------
P
R
Y
V
H
V
S
N
S
A
T
A
L
W
H
P
---
D
V
--
P
--
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
S
G
N
-
K
L
A
-
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
F
T
-
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
--
E
---
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
N
-------------
6
PsiBlast_PDB
70.24
38%
-102
- C1 -
3E6E
2
?
A:
[5-371]
----
W
H
R
P
T
R
L
----
H
-
I
D
T
Q
A
I
T
E
N
V
Q
-
K
E
C
Q
-
R
L
P
-
E
G
T
-
A
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
-
L
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
A
A
L
Q
Q
L
T
P
E
S
--
N
T
P
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
-
T
P
E
-
E
-
T
K
Q
A
V
R
---
F
V
Q
-
S
H
---
K
E
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
-
I
-
D
-
T
-
S
Y
F
----
E
K
Q
A
G
R
F
K
A
V
L
A
-
V
L
E
----
E
----
L
------
P
R
Y
V
H
V
S
N
S
A
T
A
L
W
H
P
---
D
V
--
P
--
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
S
G
N
-
K
L
A
-
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
F
T
-
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
--
E
---
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
N
-------------
65
HHSearch
69.65
38%
-102
* C1 *
3E5P
5
?
A:
[4-371]
---
G
W
H
R
P
T
R
L
----
H
-
I
D
T
Q
A
I
T
E
N
V
Q
-
K
E
C
Q
-
R
L
P
E
G
T
A
-
L
F
-
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
-
L
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
A
A
L
Q
Q
L
T
P
E
S
--
N
T
P
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
-
T
P
E
-
E
-
T
K
Q
A
V
R
---
F
V
Q
-
S
H
---
K
E
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
-
I
-
D
T
S
-
Y
F
E
----
K
-
Q
A
G
R
F
K
A
V
---
L
A
V
----
L
----
E
-
E
L---
P
R
Y
V
H
V
S
N
S
A
T
A
L
W
H
P
---
D
V
--
P
--
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
S
G
N
K
-
L
A
-
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
F
T
-
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
--
E
---
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
N
-------------
14
PsiBlast_PDB
67.61
31%
-110
- C1 -
3CO8
1
LYSR_OENOB
A:
[7-368]
-----
H
R
S
T
R
I
----
E
-
F
S
K
S
S
L
A
Y
N
V
Q
-
Y
T
K
Q
-
V
S
G
-
A
K
T
-
L
W
-
L
A
V
K
S
N
A
Y
G
H
G
L
L
Q
V
S
K
I
A
R
E
C
G
V
D
G
L
A
V
S
V
L
D
E
G
I
A
I
R
Q
A
G
I
D
D
F
I
-
L
I
L
G
P
I
D
V
K
Y
A
P
I
A
S
K
Y
H
F
L
T
T
V
S
S
L
D
W
L
K
S
A
D
K
I
L
G
K
E
-----
K
L
S
V
N
L
A
V
D
T
G
M
N
R
I
G
V
R
-
S
K
K
-
D
-
L
K
D
E
I
E
---
F
L
Q
-
E
H
S--
D
H
F
S
Y
D
G
I
F
T
H
F
A
-------------
F
----
Q
R
Q
K
N
R
W
Y
E
L
---
I
D
G
----
L
----
I
-
M
----
P
R
Y
V
H
V
M
N
S
G
A
A
M
Y
H
S
---
K
E
--
L
PG
C
N
S
I
A
R
V
G
T
V
V
Y
G
V
E
P
S
E
G
V
L
G
P
-
I
D
-
K
L
K
P
V
F
E
L
K
S
A
L
T
F
V
K
K
I
P
A
G
E
G
I
S
Y
G
S
K
F
V
T
S
R
D
T
W
I
G
T
L
P
I
G
Y
G
D
G
W
L
A
E
Y
Q
-
D
F
Q
-
L
L
I
D
G
Q
K
C
R
Q
V
G
Q
I
A
M
D
Q
M
M
V
A
L
---
P
H
--
E
---
Y
P
I
G
T
E
V
T
L
I
G
K
S
G
K
Y
E
N
T
L
Y
D
L
H
K
H
S
G
V
P
P
W
K
I
T
V
A
F
S
D
R
L
K
R
----------------
29
PsiBlast_CBE
67.53
32%
-111
- C1 -
1XFC
1
ALR_MYCTU
B:
[16-381]
-----------------
V
D
L
G
A
I
E
H
N
V
R
-
V
L
R
E
-
H
A
G
-
H
A
Q
-
L
M
-
A
V
V
K
A
D
G
Y
G
H
G
A
T
R
V
A
Q
T
A
L
G
A
G
A
A
E
L
G
V
A
T
V
D
E
A
L
A
L
R
A
D
G
I
T
A
P
V
-
L
A
W
L
H
P
P
G
I
D
F
G
P
A
L
L
A
D
V
Q
V
A
V
S
S
L
R
Q
L
D
E
L
L
H
A
V
R
-
R
T
--
G
R
T
A
T
V
T
V
K
V
D
T
G
L
N
R
N
G
V
G
-
P
A
Q
---
F
P
A
M
L
T
---
A
L
R
-
Q
A
M
A
E
D
A
V
R
L
R
G
L
M
S
H
M
V
Y
A
D
K
-
P
-
D
-
D
-
S
I
N
----
D
V
Q
A
Q
R
F
T
A
F
---
L
A
Q
----
A
R
E
Q
G
V
-
R
----
F
E
V
A
H
L
S
N
S
S
A
T
M
A
R
P
---
D
L
--
T
--
F
D
L
V
-
R
P
G
I
A
V
Y
G
L
S
P
---
V
P
A
L
-
G
D
M
G
L
V
P
A
M
T
V
K
C
A
V
A
L
V
K
S
I
R
---------------
D
T
N
L
A
L
L
P
I
G
Y
A
D
G
V
F
R
S
L
G
-
G
R
L
E
V
L
I
N
G
R
R
C
P
G
V
G
R
I
C
M
D
Q
F
M
V
D
L
GPG
P
L
--
D
---
V
A
E
G
D
E
A
I
L
F
G
P
G
I
R
G
E
P
T
A
Q
D
W
A
D
L
V
G
T
I
H
Y
E
V
V
T
S
P
R
G
R
I
T
R
T
Y
R
E
A
-----------
67
HHSearch
66.93
31%
-108
- C1 -
3CO8
1
LYSR_OENOB
A:
[6-371]
----
I
H
R
S
T
R
I
----
E
-
F
S
K
S
S
L
A
Y
N
V
Q
-
Y
T
K
Q
-
V
S
G
-
A
K
T
-
L
W
-
L
A
V
K
S
N
A
Y
G
H
G
L
L
Q
V
S
K
I
A
R
E
C
G
V
D
G
L
A
V
S
V
L
D
E
G
I
A
I
R
Q
A
G
I
D
D
F
I
-
L
I
L
G
P
I
D
V
K
Y
A
P
I
A
S
K
Y
H
F
L
T
T
V
S
S
L
D
W
L
K
S
A
D
K
I
L
---
G
--
K
E
K
L
S
V
N
L
A
V
D
T
G
M
N
R
I
G
V
R
-
S
-
K
K
D
-
L
K
D
E
I
E
---
F
L
Q
E
H
S
---
D
H
F
S
Y
D
G
I
F
T
H
F
A
------------
F
Q
----
R
-
Q
K
N
R
W
Y
E
L
---
I
D
G
----
L
----
I
-
M
----
P
R
Y
V
H
V
M
N
S
G
A
A
M
Y
H
S
KEL
P
G
--
C
--
N
S
I
A
-
R
V
G
T
V
V
Y
G
V
E
P
S
E
G
V
-
L
G
-
P
I
D
K
L
K
P
V
F
E
L
K
S
A
L
T
F
V
K
K
I
P
A
G
E
G
I
S
Y
G
S
K
F
V
T
S
R
D
T
W
I
G
T
L
P
I
G
Y
G
D
G
W
L
A
E
Y
Q
-
D
F
Q
-
L
L
I
D
G
Q
K
C
R
Q
V
G
Q
I
A
M
D
Q
M
M
V
A
L
---
P
H
--
E
---
Y
P
I
G
T
E
V
T
L
I
G
K
S
G
K
Y
E
N
T
L
Y
D
L
H
K
H
S
G
V
P
P
W
K
I
T
V
A
F
S
D
R
L
K
R
M
V
V
-------------
69
HHSearch
65.96
32%
-100
- C1 -
1XFC
1
ALR_MYCTU
A:
[11-381]
-----------LAEA
M
-
V
D
L
G
A
I
E
H
N
V
R
-
V
L
R
E
-
H
A
G
-
H
A
Q
-
L
M
-
A
V
V
K
A
D
G
Y
G
H
G
A
T
R
V
A
Q
T
A
L
G
A
G
A
A
E
L
G
V
A
T
V
D
E
A
L
A
L
R
A
D
G
I
T
A
P
V
L
A
W
L
H
P
P
G
-
I
D
F
G
P
A
L
L
A
D
V
Q
V
A
V
S
S
L
R
Q
L
D
E
L
L
H
A
V
R
-
R
T
--
G
R
T
A
T
V
T
V
K
V
D
T
G
L
N
R
N
G
V
G
-
P
-
A
-
Q
-
F
P
A
M
L
T
A
L
R
Q
A
M
-
A
E
---
D
A
V
R
L
R
G
L
M
S
H
M
------
P
-
D
-
D
S
I
N
D
----
V
-
Q
A
Q
R
F
T
A
F
---
L
A
Q
----
A
----
R
-
E
Q
GVR
F
E
V
A
H
L
S
N
S
S
A
T
M
A
R
P
---
D
L
--
T
--
F
D
L
V
-
R
P
G
I
A
V
Y
G
L
S
P
V
P
---
A
L
-
G
D
M
G
L
V
P
A
M
T
V
K
C
A
V
A
L
V
K
S
I
R
A
G
E
G
V
S
Y
G
H
T
W
I
A
P
R
D
T
N
L
A
L
L
P
I
G
Y
A
D
G
V
F
R
S
L
G
G
R
L
E
-
V
L
I
N
G
R
R
C
P
G
V
G
R
I
C
M
D
Q
F
M
V
D
L
---
G
P
--
G
PLD
V
A
E
G
D
E
A
I
L
F
G
P
G
I
R
G
E
P
T
A
Q
D
W
A
D
L
V
G
T
I
H
Y
E
V
V
T
S
P
R
G
R
I
T
R
T
Y
R
E
A
-----------
54
Fugue
57.16
44%
-102
- C1 -
1BD0
1
ALR_GEOSE
A:
[12-244]
-----------------
V
D
L
D
A
I
Y
D
N
V
E
-
N
L
R
R
L
L
P
D
-
D
T
H
-
I
M
-
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
-
L
V
L
G
A
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
E
A
S
A
L
Y
S
G
P
----
F
P
I
H
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
-
D
E
E
-
E
-
T
K
R
I
V
A
---
L
I
E
-
R
H
---
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
-
V
N
T
-
D
-
Y
F
S
----
Y
-
Q
Y
T
R
F
L
H
M
---
L
E
W
L---
P
----
S
-
R
----
P
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
---
D
R
--
T
--
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
-
L
P
Y
P
L
K
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------
56
Fugue
54.53
41%
-99
- C1 -
1BD0
1
ALR_GEOSE
A:
[12-244]
-----
V
D
L
D
A
I
----
Y
-
D
N
V
E
N
L
R
R
L
L
P
-
D
--------
D
T
H
-
I
M
-
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
-
L
V
L
G
A
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
E
A
S
A
L
Y
---
S
GP
F
-
P
I
H
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
-
D
E
E
-
E
-
T
K
R
I
V
A
---
L
I
E
-
R
H
---
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
-
V
N
T
-
D
-
Y
F
S
----
Y
-
Q
Y
T
R
F
L
H
M
L
E
W
L
P
S
-----------
R
----
P
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
---
D
R
--
T
--
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
-
L
P
Y
P
L
K
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------