@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1885: (2016-03-29 )
MQNFKELGISDNTVQSLESMGFKEPTPIQKDSIPYALQGIDILGQAQTGTGKTGAFGIPLIEKVVGKQGVQSLILAPTRELAMQVAEQLREFSRGQGVQVVTVFGGMPIERQIKALKKGPQIVVGTPGRVIDHLNRRTLKTDGIHTLILDEADEMMNMGFIDDMRFIMDKIPAVQRQTMLFSATMPKAIQALVQQFMKSPKIIKTMNNEMSDPQIEEFYTIVKELEKFDTFTNFLDVHQPELAIVFGRTKRRVDELTSALISKGYKAEGLHGDITQAKRLEVLKKFKNDQINILVATDVAARGLDISGVSHVYNFDIPQDTESYTHRIGRTGRAGKEGIAVTFVNPIEMDYIRQIEDANGRKMSALRPPHRKEVLQAREDDIKEKVENWMSKESESRLKRISTELLNEYNDVDLVAALLQELVEANDEVEVQLTFEKPLSRKGRNGKPSGSRNRNSKRGNPKFDSKSKRSKGYSSKKKSTKKFDRKEKSSGGSRPMKGRTFADHQK
Atome Classification :
(70 SA)
.........10.........20........30.......--.--40-.........50......-..----60-------...--.--------.-------------------.-------------------.-------.-70--.........80...---.....90..-..-.----..---.100........110...-...-.-120-----........130..---..-.-..140--.......150....---..-.-160-.....-....170-.---..------.------.....180.......190.......200.--......----.----210.......220-.-.-.-.-.----.----.230------....-.-.--.-.240-........250.......260.---......270.......280.......290.......300.......310......------.------320.......330.......340....-----..-.350......-.360.......370.......-380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQ
N
F
K
ELGIS-D
N
T
V
Q
S
L
E
SMGFKEPTPIQKDSI
P
Y
A
L
Q
--
G
--
I
--
D
I
L
GQAQTGTGKTGAF
G
-
I
P
----
L
I
-------
E
K
V
--
V
--------
G
-------------------
K
-------------------
Q
-------
G
-
V
---
Q
S
L
I
LA
P
T
R
E
L
A
M
Q
---
V
A
E
Q
L
R
E
F
S-RG-Q----G
V
---
Q
V
-
V
T
VFGGM
P
I
E
R
Q
I
K
A
-
L
KK-G-P
Q
------
I
V
VGT
P
G
R
V
I
D
H
L
---NR-R-TLKTD--G
I
H
T
L
I
LD
E
A
D
E
M
M
---NM-G-
F
---
I
D
D
M
R
-
F
I
M
D
K---I---P
A
------
V
------
Q
R
Q
T
M
L
FSAT
M
P
K
A
I
Q
A
L
V
Q
Q
F
M
KSP-K
I
--
I
K
T
MNN----E----MS
D
P
Q
I
E
E
F
Y
T
I
V
-
K
-
E
-
L
-
E
-
K
----
F
----
D
T
F
-------
T
N
F
L
-D-V--H-QP
E
--
L
A
I
V
FGR
T
K
R
R
V
D
E
L
T
S
A
L
I
SK---GYKAEGLHG
D
I
T
Q
A
K
R
L
E
V
L
K
K
FKND
Q
I
N
I
L
V
ATDVAARGLDISGV
S
H
V
Y
NFDIP------Q------D
T
E
S
Y
T
H
R
IGRTGRAGKE
G
I
A
V
T
F
VNP-----I
E
-
M
D
Y
I
R
Q
I
EDA-NGRKMSALRPP
H
R
K
E
V
L
Q
A
R
E
-
D
D
I
K
E
K
V
E
N
W
M
S
K
E
S
E
S
R
L
K
R
I
S
T
E
L
L
N
EYN
D
V
D
L
V
A
A
L
L
Q
E
L
V
EAND
E
V
E
V
Q
L
T
FEKPLSRKGRNGKPSGSRNRNSKRGNPKFDSKSKRSKGYSSKKK
S
T
K
K
F
D
R
K
EKSSGGSRPMKGRTFADHQK
123
HHSearch
92.13
40%
-98
- C4 -
2I4I
1
DDX3X_HUMAN
A:
[15-386]
-
E
S
F
S
D
V
E
M
G
-
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
--
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
-
L
P
----
I
L
-------
S
Q
I
--
Y
--------
S
-------------------
D
GPG
E
A
L
R
A
M
K
E
NGRYGRR
K
Q
-------
Y
-
P
---
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
---
I
Y
E
E
A
R
K
F
S
-
Y
R
-
S
----
R
V
---
R
P
-
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
-
L
E
R
-
G
-
C
H
------
L
L
V
A
T
P
G
R
L
V
D
M
M
---
E
R
-
G
-
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
---
E
P
Q
I
R
-
R
I
V
E
Q
---
D
TMP
P
K
------
G
------
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
-
I
F
--
L
A
V
G
------------
T
S
E
N
I
T
Q
K
V
V
W
V
-
E
-
E
-
S
-
D
-
K
----
R
----
S
F
L
-------
L
D
L
L
-
N
A
T
--
G
-
K
D
S
--
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
E
-----
R
N
-
I
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.96
43%
-97
- C4 -
1HV8
5
H669_METJA
A:
[7-356]
--
N
F
N
E
L
N
L
S
-
D
N
I
L
N
A
I
R
N
K
G
F
E
K
P
T
D
I
Q
M
K
V
I
P
L
F
L
N
--
D
E-
Y
--
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
-
I
P
----
L
I
-------
E
L
V
--
N
--------
E
-------------------
N
-------------------
N
-------
G
-
I
---
E
A
I
I
L
T
P
T
R
E
L
A
I
Q
---
V
A
D
E
I
E
S
L
K
-
G
N
-
K
----
N
L
---
K
I
-
A
K
I
Y
G
G
K
A
I
Y
P
Q
I
K
A
-
L
K
N
-
A
--
N
------
I
V
V
G
T
P
G
R
I
L
D
H
I
---
N
R
-
G
-
T
L
N
L
K
--
N
V
K
Y
F
I
L
D
E
A
D
E
M
L
---
N
M
-
G
-
F
---
I
K
D
V
E
-
K
I
L
N
A
---
C
---
N
K
------
D
------
K
R
-
I
L
L
F
S
A
T
M
P
R
E
I
L
N
L
A
K
K
Y
M
G
D
Y
-
S
F
--
I
K
A
K
I
N
------------
A
N
I
E
Q
S
Y
V
E
V
-
N
-
E
-
N
-
E
-
R
----
F
----
E
A
L
-------
C
R
L
L
-
K
----
N
-
K
E
F
--
Y
G
L
V
F
C
K
T
K
R
D
T
K
E
L
A
S
M
L
R
D
I
---
G
F
K
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
------
Q
------
N
P
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
N
R
-----
R
E
-
Y
K
K
L
R
Y
I
E
R
A
------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
90.85
44%
-91
- C4 -
1HV8
5
H669_METJA
A:
[6-362]
-
M
N
F
N
E
L
N
L
S
-
D
N
I
L
N
A
I
R
N
K
G
F
E
K
P
T
D
I
Q
M
K
V
I
P
L
F
L
N
--
D
E-
Y
--
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
-
I
P
----
L
I
-------
E
L
V
--
N
--------
E
-------------------
N
-------------------
N
-------
G
-
I
---
E
A
I
I
L
T
P
T
R
E
L
A
I
Q
---
V
A
D
E
I
E
S
L
K
-
G
N
-
K
----
N
L
---
K
I
-
A
K
I
Y
G
G
K
A
I
Y
P
Q
I
K
--
A
L
K
-
N
-
A
N
------
I
V
V
G
T
P
G
R
I
L
D
H
I
---
N
R
-
G
-
T
L
N
L
K
--
N
V
K
Y
F
I
L
D
E
A
D
E
M
L
---
N
M
-
G
-
F
---
I
K
D
V
E
-
K
I
L
N
A
---
C
---
N
K
------
D
-------
K
R
I
L
L
F
S
A
T
M
P
R
E
I
L
N
L
A
K
K
Y
M
G
D
Y
-
S
F
--
I
K
A
K
------------
I
N
A
N
I
E
Q
S
Y
V
E
V
-
N
-
E
-
N
-
E
-
R
----
F
----
E
A
L
-------
C
R
L
L
-
K
----
N
-
K
E
F
--
Y
G
L
V
F
C
K
T
K
R
D
T
K
E
L
A
S
M
L
R
D
I
---
G
F
K
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
------
Q
------
N
P
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
N
R
-----
R
E
-
Y
K
K
L
R
Y
I
E
R
A
-
M
K
L
K
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
90.66
38%
-98
- C4 -
2I4I
1
DDX3X_HUMAN
A:
[14-381]
I
E
S
F
S
D
V
E
M
G
-
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
--
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
-
L
P
----
I
L
-------
S
Q
I
--
Y
--------
S
DGPG
E
A
L
R
A
M
K
E
NGRYGRR
K
-------------------
Q
-------
Y
-
P
---
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
---
I
Y
E
E
A
R
K
F
S
-
Y
R
-
S
----
R
V
---
R
P
-
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
-
L
E
R
-
G
-
C
H
------
L
L
V
A
T
P
G
R
L
V
D
M
M
---
E
R
-
G
-
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
---
E
P
Q
I
R
-
R
I
V
E
Q
DTM
P
---
P
K
------
G
------
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
-
I
F
--
L
A
V
G
------------
T
S
E
N
I
T
Q
K
V
V
W
V
-
E
-
E
-
S
-
D
-
K
----
R
----
S
F
L
-------
L
D
L
L
-
N
-
A
--
T
G
K
D
S
--
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
89.70
38%
-89
- C4 -
4PXA
5
DDX3X_HUMAN
A:
[64-431]
I
E
S
F
S
D
V
E
M
G
-
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
--
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
-
L
P
----
I
L
-------
S
Q
I
--
Y
--------
S
DGPG
E
A
L
R
A
M
K
E
NGRYGRR
K
-------------------
Q
-------
Y
-
P
---
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
---
I
Y
E
E
A
R
K
F
S
-
Y
R
-
S
----
R
V
---
R
P
-
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
-
L
E
R
-
G
-
C
H
------
L
L
V
A
T
P
G
R
L
V
D
M
M
---
E
R
-
G
-
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
V
M
-
G
-
F
---
E
P
Q
I
R
-
R
I
V
E
Q
DTM
P
---
P
K
------
G
------
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
-
I
F
--
L
A
V
G
R
V
----
G
----
S
T
S
E
N
I
T
Q
K
V
V
W
V
-
E
-
E
-
S
-
D
-
K
----
R
----
S
F
L
-------
L
D
L
L
-
N
-
A
--
T
G
K
D
S
--
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
88.58
31%
-96
- C4 -
4LK2
1
PRP5_YEAST
A:
[52-466]
---
W
S
Q
L
G
L
S
T
D
T
M
V
L
I
T
-
K
L
H
F
G
S
L
T
P
I
Q
S
Q
A
L
P
A
I
M
S
--
G
--
R
--
D
V
I
G
I
S
K
T
G
S
G
K
T
I
S
Y
L
-
L
P
----
L
L
-------
R
Q
V
--
K
--------
A
-------------------
Q
-------------------
R
PLSKHET
G
-
P
---
M
G
L
I
L
A
P
T
R
E
L
A
L
Q
---
I
H
E
E
V
T
K
F
T
-
E
A
-
D
T---
S
I
---
R
S
-
V
C
C
T
G
G
S
E
M
K
K
Q
I
T
D
-
L
K
R
-
G
-
T
E
------
I
V
V
A
T
P
G
R
F
I
D
I
L
T
LN
D
G
-
K
-
L
L
S
T
K
--
R
I
T
F
V
V
M
D
E
A
D
R
L
F
---
D
L
-
G
-
F
---
E
P
Q
I
T
-
Q
I
M
K
T
---
V
---
R
P
-------------
D
K
Q
C
V
L
F
S
A
T
F
P
N
K
L
R
S
F
A
V
R
V
L
H
S
P
-
I
S
--
I
T
I
N
S
K
----
G
----
M
V
N
E
N
V
K
Q
K
F
R
I
C
H
S
-
E
-
D
-
E
-
K
----
F
----
D
N
L
V
Q
L
I
H
E
R
S
E
F
F
-----------D
A
K
A
I
I
F
V
S
S
Q
N
I
C
D
F
I
S
K
K
L
L
N
A
---
G
I
V
T
C
A
I
H
A
G
K
P
Y
Q
E
R
L
M
N
L
E
K
F
K
R
E
K
N
S
I
L
L
C
T
E
V
L
S
R
G
L
N
V
P
E
V
S
L
V
I
I
Y
N
A
V
------
K
------
T
F
A
Q
Y
V
H
T
T
G
R
T
A
R
G
S
R
S
G
T
A
I
T
L
L
L
H
-----
D
E
-
L
S
G
A
Y
I
L
S
K
A
M
R
D
E
E
I
K
A
L
D
P
------
L
Q
A
K
E
L
Q
E
M
S
A
K
F
E
S
G
M
--------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
87.85
39%
-88
- C4 -
4KBG
4
?
B:
[2-361]
--
E
F
K
D
F
P
L
K
-
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
--
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
-
L
P
----
I
A
-------
E
R
L
--
A
--------
P
-------------------
S
-------------------
Q
ERGR---
K
-
P
---
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
A
----
P
----
H
L
---
K
V
-
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
-
L
L
R
-
G
-
A
D
------
A
V
V
A
T
P
G
R
A
L
D
Y
L
---
R
Q
-
G
-
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
---
E
E
E
V
E
-
A
L
L
S
A
---
T
---
P
P
-------------
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
-
V
L
--
I
N
V
I
K
D
----
E
----
P
V
T
Y
E
E
E
A
V
P
A
P
V
-
R
-
G
-----
R
----
L
----
E
V
L
-------
S
D
L
L
-
Y
-
V
--
A
-
S
P
D
--
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
---
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
------
D
------
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
-----
R
E
-
R
R
D
V
E
A
L
E
R
A
-
V
G
R
R
F
------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
87.52
39%
-94
- C4 -
4KBF
1
?
B:
[2-361]
--
E
F
K
D
F
P
L
K
-
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
--
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
-
L
P
----
I
A
-------
E
R
L
--
A
--------
P
-------------------
S
-------------------
Q
ERGR---
K
-
P
---
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
A
----
P
----
H
L
---
K
V
-
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
-
L
L
R
-
G
-
A
D
------
A
V
V
A
T
P
G
R
A
L
D
Y
L
---
R
Q
-
G
-
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
---
E
E
E
V
E
-
A
L
L
S
A
---
T
---
P
P
-------------
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
-
V
L
--
I
N
V
I
K
D
----
E
----
P
V
T
Y
E
E
E
A
V
P
A
P
V
-
R
-
G
-----
R
----
L
----
E
V
L
-------
S
D
L
L
-
Y
-
V
--
A
-
S
P
D
--
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
---
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
------
D
------
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
-----
R
E
-
R
R
D
V
E
A
L
E
R
A
-
V
G
R
R
F
------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
87.52
33%
-93
- C4 -
1S2M
-
DHH1_YEAST
A:
[48-422]
---
F
E
D
F
Y
L
K
-
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
--
G
--
R
--
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
-
I
P
----
T
L
-------
E
K
V
--
K
--------
P
-------------------
K
-------------------
L
-------
N
K
I
---
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
---
T
S
Q
V
V
R
T
L
G
-
K
H
-
C
----
G
I
---
S
C
-
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
-
L
N
E
-
T
-
V
H
------
I
L
V
G
T
P
G
R
V
L
D
L
A
---
S
R
-
K
-
V
A
D
L
S
--
D
C
S
L
F
I
M
D
E
A
D
K
M
L
---
S
R
-
D
-
F
---
K
T
I
I
E
-
Q
I
L
S
F
---
L
---
P
P
------
T
------
H
-
Q
S
L
L
F
S
A
T
F
P
L
T
V
K
E
F
M
V
K
H
L
H
K
P
-
Y
E
--
I
N
L
M
E
-----
E
----
L
T
L
K
G
I
T
Q
Y
Y
A
F
V
-
E
-
E
-
R
-
Q
-
K
----
L
----
H
C
L
-------
N
T
L
F
-
S
-
K
--
L
-
Q
I
N
--
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
---
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
------
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
-----
N
D
-
R
F
N
L
Y
K
I
E
Q
E
-
L
G
T
E
I
A
A
I
P
A
T
I
D
K
S
L
Y
V
A
E
N
--------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
86.99
36%
-108
- C4 -
2VSO
1
IF4A_YEAST
B:
[24-376]
---
F
D
D
M
E
L
D
-
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
--
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
-
I
A
----
A
L
-------
Q
R
I
D-
T
--------
S
-------------------
V
-------------------
K
-------
A
-
P
---
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
---
I
Q
K
V
V
M
A
L
A
-
F
H
-
M
----
D
I
---
K
V
-
H
A
C
I
G
-----------
L
R
D
-
A
--
Q
------
I
V
V
G
T
P
G
R
V
F
D
N
I
---
Q
R
-
R
-
R
F
R
T
D
--
K
I
K
M
F
I
L
D
E
A
D
E
M
L
---
S
S
-
G
-
F
---
K
E
Q
I
Y
-
Q
I
F
T
L
---
L
---
P
P
------
T
------
T
-
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
-
V
R
--
I
L
V
K
K
D
----
E
----
L
T
L
E
G
I
K
Q
F
Y
V
N
V
-
E
-
E
-
E
-
E
Y
K
----
Y
----
E
C
L
-------
T
D
L
Y
-
D
-
S
--
I
-
S
V
T
--
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
-----
E
D
-
V
G
A
M
R
E
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
86.81
39%
-86
- C4 -
4KBF
3
?
A:
[2-361]
--
E
F
K
D
F
P
L
K
-
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
--
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
-
L
P
----
I
A
-------
E
R
L
--
A
--------
P
-------------------
S
-------------------
Q
ERGR---
K
-
P
---
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
A
----
P
----
H
L
---
K
V
-
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
-
L
L
R
-
G
-
A
D
------
A
V
V
A
T
P
G
R
A
L
D
Y
L
---
R
Q
-
G
-
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
---
E
E
E
V
E
-
A
L
L
S
A
---
T
---
P
P
-------------
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
-
V
L
--
I
N
V
I
K
D
----
E
----
P
V
T
Y
E
E
E
A
V
P
A
P
V
-
R
-
G
-----
R
----
L
----
E
V
L
-------
S
D
L
L
-
Y
-
V
--
A
-
S
P
D
--
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
---
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
------
D
------
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
-----
R
E
-
R
R
D
V
E
A
L
E
R
A
-
V
G
R
R
F
------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.63
37%
-89
- C4 -
2J0S
3
IF4A3_HUMAN
A:
[38-392]
--
T
F
D
T
M
G
L
R
-
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
--
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
-
I
S
----
V
L
-------
Q
C
L
D-
I
--------
Q
-------------------
V
-------------------
R
-------
E
-
T
---
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
---
I
Q
K
G
L
L
A
L
G
-
D
Y
-
M
----
N
V
---
Q
C
-
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
-
L
D
Y
-
G
-
Q
H
------
V
V
A
G
T
P
G
R
V
F
D
M
I
---
R
R
-
R
-
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
---
K
E
Q
I
Y
-
D
V
Y
R
Y
---
L
---
P
P
------
A
------
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
-
I
R
--
I
L
V
K
R
D
----
E
----
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
----
F
----
D
T
L
-------
C
D
L
Y
-
D
-
T
--
L
-
T
I
T
--
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
-----
D
D
-
I
R
I
L
R
D
I
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
86.49
36%
-106
- C4 -
2VSO
1
IF4A_YEAST
A:
[24-376]
---
F
D
D
M
E
L
D
-
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
--
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
-
I
A
----
A
L
-------
Q
R
I
D-
T
--------
S
-------------------
V
-------------------
K
-------
A
-
P
---
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
---
I
Q
K
V
V
M
A
L
A
-
F
H
-
M
----
D
I
---
K
V
-
H
A
C
I
G
-----------
L
R
D
-
A
--
Q
------
I
V
V
G
T
P
G
R
V
F
D
N
I
---
Q
R
-
R
-
R
F
R
T
D
--
K
I
K
M
F
I
L
D
E
A
D
E
M
L
---
S
S
-
G
-
F
---
K
E
Q
I
Y
-
Q
I
F
T
L
---
L
---
P
P
------
T
------
T
-
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
-
V
R
--
I
L
V
K
K
D
----
E
----
L
T
L
E
G
I
K
Q
F
Y
V
N
V
-
E
-
E
-
E
-
E
Y
K
----
Y
----
E
C
L
-------
T
D
L
Y
-
D
-
S
--
I
-
S
V
T
--
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
-----
E
D
-
V
G
A
M
R
E
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
86.40
33%
-94
- C4 -
1S2M
-
DHH1_YEAST
A:
[46-411]
-
N
T
F
E
D
F
Y
L
K
-
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
--
G
--
R
--
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
-
I
P
----
T
L
-------
E
K
V
--
K
--------
P
-------------------
K
L------------------
N
-------
K
-
I
---
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
---
T
S
Q
V
V
R
T
L
G
-
K
H
-
C
----
G
I
---
S
C
-
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
-
L
N
E
-
T
-
V
H
------
I
L
V
G
T
P
G
R
V
L
D
L
A
---
S
R
-
K
-
V
A
D
L
S
--
D
C
S
L
F
I
M
D
E
A
D
K
M
L
---
S
R
-
D
-
F
---
K
T
I
I
E
-
Q
I
L
S
F
---
L
---
P
P
------
T
-------
H
Q
S
L
L
F
S
A
T
F
P
L
T
V
K
E
F
M
V
K
H
L
H
K
P
-
Y
E
--
I
N
L
M
E
E
---------
L
T
L
K
G
I
T
Q
Y
Y
A
F
V
-
E
-
E
-
R
-
Q
-
K
----
L
----
H
C
L
-------
N
T
L
F
-
S
-
K
--
L
-
Q
I
N
--
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
---
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
------
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
-----
N
D
-
R
F
N
L
Y
K
I
E
Q
E
-
L
G
T
E
I
A
A
I
P
A
-------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
86.17
37%
-87
- C4 -
2HYI
3
IF4A3_HUMAN
C:
[39-393]
--
T
F
D
T
M
G
L
R
-
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
--
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
-
I
S
----
V
L
-------
Q
C
L
D-
I
--------
Q
-------------------
V
-------------------
R
-------
E
-
T
---
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
---
I
Q
K
G
L
L
A
L
G
-
D
Y
-
M
----
N
V
---
Q
C
-
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
-
L
D
Y
-
G
-
Q
H
------
V
V
A
G
T
P
G
R
V
F
D
M
I
---
R
R
-
R
-
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
---
K
E
Q
I
Y
-
D
V
Y
R
Y
---
L
---
P
P
------
A
------
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
-
I
R
--
I
L
V
K
R
D
----
E
----
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
----
F
----
D
T
L
-------
C
D
L
Y
-
D
-
T
--
L
-
T
I
T
--
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
-----
D
D
-
I
R
I
L
R
D
I
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
86.05
37%
-86
- C4 -
2HYI
3
IF4A3_HUMAN
I:
[39-393]
--
T
F
D
T
M
G
L
R
-
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
--
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
-
I
S
----
V
L
-------
Q
C
L
D-
I
--------
Q
-------------------
V
-------------------
R
-------
E
-
T
---
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
---
I
Q
K
G
L
L
A
L
G
-
D
Y
-
M
----
N
V
---
Q
C
-
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
-
L
D
Y
-
G
-
Q
H
------
V
V
A
G
T
P
G
R
V
F
D
M
I
---
R
R
-
R
-
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
---
K
E
Q
I
Y
-
D
V
Y
R
Y
---
L
---
P
P
------
A
------
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
-
I
R
--
I
L
V
K
R
D
----
E
----
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
----
F
----
D
T
L
-------
C
D
L
Y
-
D
-
T
--
L
-
T
I
T
--
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
-----
D
D
-
I
R
I
L
R
D
I
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
86.05
37%
-86
- C4 -
2XB2
4
IF4A3_HUMAN
A:
[39-393]
--
T
F
D
T
M
G
L
R
-
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
--
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
-
I
S
----
V
L
-------
Q
C
L
D-
I
--------
Q
-------------------
V
-------------------
R
-------
E
-
T
---
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
---
I
Q
K
G
L
L
A
L
G
-
D
Y
-
M
----
N
V
---
Q
C
-
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
-
L
D
Y
-
G
-
Q
H
------
V
V
A
G
T
P
G
R
V
F
D
M
I
---
R
R
-
R
-
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
---
K
E
Q
I
Y
-
D
V
Y
R
Y
---
L
---
P
P
------
A
------
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
-
I
R
--
I
L
V
K
R
D
----
E
----
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
----
F
----
D
T
L
-------
C
D
L
Y
-
D
-
T
--
L
-
T
I
T
--
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
-----
D
D
-
I
R
I
L
R
D
I
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
116
HHSearch
85.95
37%
-77
- C4 -
2DB3
3
VASA1_DROME
A:
[56-408]
-
Q
H
F
T
S
A
D
L
R
-
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
--
G
--
R
--
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
-
L
P
----
I
L
-------
S
K
L
--
L
--------
E
-------------------
D
P
H
E
L
E
L
-------------
G
-------
R
-
P
---
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
---
I
F
N
E
A
R
K
F
A
-
F
E
-
S
----
Y
L
---
K
I
-
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
-
I
T
R
-
G
-
C
H
------
V
V
I
A
T
P
G
R
L
L
D
F
V
---
D
R
-
T
-
F
I
T
F
E
--
D
T
R
F
V
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
---
S
E
D
M
R
-
R
I
M
T
H
---
V
---
T
M
R-----
P
------
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
-
V
F
--
V
A
I
G
I
V
----
G
----
G
A
C
S
D
V
K
Q
T
I
Y
E
V
-
N
-
K
-
Y
-
A
-
K
----
R
----
S
K
L
-------
I
E
I
L
-
S
----
E
-
Q
A
D
--
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
---
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
------
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
-----
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.86
37%
-87
- C4 -
2J0Q
3
IF4A3_HUMAN
A:
[38-392]
--
T
F
D
T
M
G
L
R
-
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
--
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
-
I
S
----
V
L
-------
Q
C
L
D-
I
--------
Q
-------------------
V
-------------------
R
-------
E
-
T
---
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
---
I
Q
K
G
L
L
A
L
G
-
D
Y
-
M
----
N
V
---
Q
C
-
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
-
L
D
Y
-
G
-
Q
H
------
V
V
A
G
T
P
G
R
V
F
D
M
I
---
R
R
-
R
-
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
---
K
E
Q
I
Y
-
D
V
Y
R
Y
---
L
---
P
P
------
A
------
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
-
I
R
--
I
L
V
K
R
D
----
E
----
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
----
F
----
D
T
L
-------
C
D
L
Y
-
D
-
T
--
L
-
T
I
T
--
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
-----
D
D
-
I
R
I
L
R
D
I
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
85.85
36%
-104
- C4 -
2VSX
1
IF4A_YEAST
A:
[24-376]
---
F
D
D
M
E
L
D
-
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
--
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
-
I
A
----
A
L
-------
Q
R
I
D-
T
--------
S
-------------------
V
-------------------
K
-------
A
-
P
---
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
---
I
Q
K
V
V
M
A
L
A
-
F
H
-
M
----
D
I
---
K
V
-
H
A
C
I
G
-----------
L
R
D
-
A
--
Q
------
I
V
V
G
T
P
G
R
V
F
D
N
I
---
Q
R
-
R
-
R
F
R
T
D
--
K
I
K
M
F
I
L
D
E
A
D
E
M
L
---
S
S
-
G
-
F
---
K
E
Q
I
Y
-
Q
I
F
T
L
---
L
---
P
P
------
T
------
T
-
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
-
V
R
--
I
L
V
K
K
D
----
E
----
L
T
L
E
G
I
K
Q
F
Y
V
N
V
-
E
-
E
-
E
-
E
Y
K
----
Y
----
E
C
L
-------
T
D
L
Y
-
D
-
S
--
I
-
S
V
T
--
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
-----
E
D
-
V
G
A
M
R
E
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
85.79
36%
-104
- C4 -
2VSX
1
IF4A_YEAST
B:
[24-376]
---
F
D
D
M
E
L
D
-
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
--
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
-
I
A
----
A
L
-------
Q
R
I
D-
T
--------
S
-------------------
V
-------------------
K
-------
A
-
P
---
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
---
I
Q
K
V
V
M
A
L
A
-
F
H
-
M
----
D
I
---
K
V
-
H
A
C
I
G
-----------
L
R
D
-
A
--
Q
------
I
V
V
G
T
P
G
R
V
F
D
N
I
---
Q
R
-
R
-
R
F
R
T
D
--
K
I
K
M
F
I
L
D
E
A
D
E
M
L
---
S
S
-
G
-
F
---
K
E
Q
I
Y
-
Q
I
F
T
L
---
L
---
P
P
------
T
------
T
-
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
-
V
R
--
I
L
V
K
K
D
----
E
----
L
T
L
E
G
I
K
Q
F
Y
V
N
V
-
E
-
E
-
E
-
E
Y
K
----
Y
----
E
C
L
-------
T
D
L
Y
-
D
-
S
--
I
-
S
V
T
--
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
-----
E
D
-
V
G
A
M
R
E
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
85.75
37%
-86
- C4 -
2J0Q
3
IF4A3_HUMAN
B:
[38-392]
--
T
F
D
T
M
G
L
R
-
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
--
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
-
I
S
----
V
L
-------
Q
C
L
D-
I
--------
Q
-------------------
V
-------------------
R
-------
E
-
T
---
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
---
I
Q
K
G
L
L
A
L
G
-
D
Y
-
M
----
N
V
---
Q
C
-
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
-
L
D
Y
-
G
-
Q
H
------
V
V
A
G
T
P
G
R
V
F
D
M
I
---
R
R
-
R
-
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
---
K
E
Q
I
Y
-
D
V
Y
R
Y
---
L
---
P
P
------
A
------
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
-
I
R
--
I
L
V
K
R
D
----
E
----
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
----
F
----
D
T
L
-------
C
D
L
Y
-
D
-
T
--
L
-
T
I
T
--
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
-----
D
D
-
I
R
I
L
R
D
I
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
85.74
37%
-87
- C4 -
3EX7
4
IF4A3_HUMAN
C:
[39-393]
--
T
F
D
T
M
G
L
R
-
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
--
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
-
I
S
----
V
L
-------
Q
C
L
D-
I
--------
Q
-------------------
V
-------------------
R
-------
E
-
T
---
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
---
I
Q
K
G
L
L
A
L
G
-
D
Y
-
M
----
N
V
---
Q
C
-
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
-
L
D
Y
-
G
-
Q
H
------
V
V
A
G
T
P
G
R
V
F
D
M
I
---
R
R
-
R
-
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
---
K
E
Q
I
Y
-
D
V
Y
R
Y
---
L
---
P
P
------
A
------
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
-
I
R
--
I
L
V
K
R
D
----
E
----
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
----
F
----
D
T
L
-------
C
D
L
Y
-
D
-
T
--
L
-
T
I
T
--
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
-----
D
D
-
I
R
I
L
R
D
I
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
85.66
34%
-79
- C4 -
4D25
4
?
A:
[49-406]
I
E
S
F
E
T
A
N
L
R
-
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
--
G
--
R
--
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
-
V
P
----
I
I
N
M
L
L
Q
D
P
K
D
L
--
I
--------
S
-------------------
E
-------------------
N
-------
G
-
C
A
Q
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
---
I
F
N
E
A
R
K
F
S
-
Y
G
-
S
----
V
L
---
K
V
-
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
-
I
A
R
-
G
-
C
H
------
I
L
V
A
T
P
G
R
L
H
D
F
V
---
E
R
-
N
-
R
V
S
F
G
--
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
---
D
M
-
G
-
F
M
P
S
I
E
K
M
M
-
L
H
P
T
M
---
V
---
E
T
------
T
------
K
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
-
L
F
--
V
A
V
G
I
V
----
G
----
G
A
S
T
D
V
E
Q
I
F
I
E
V
-
T
-
K
-
Y
-
E
-
K
----
R
----
N
S
L
-------
K
Q
L
I
-
E
-
E
--
N
-
D
G
K
--
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
---
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
------
K
------
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
85.46
37%
-85
- C4 -
3EX7
4
IF4A3_HUMAN
H:
[39-393]
--
T
F
D
T
M
G
L
R
-
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
--
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
-
I
S
----
V
L
-------
Q
C
L
D-
I
--------
Q
-------------------
V
-------------------
R
-------
E
-
T
---
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
---
I
Q
K
G
L
L
A
L
G
-
D
Y
-
M
----
N
V
---
Q
C
-
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
-
L
D
Y
-
G
-
Q
H
------
V
V
A
G
T
P
G
R
V
F
D
M
I
---
R
R
-
R
-
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
---
K
E
Q
I
Y
-
D
V
Y
R
Y
---
L
---
P
P
------
A
------
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
-
I
R
--
I
L
V
K
R
D
----
E
----
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
----
F
----
D
T
L
-------
C
D
L
Y
-
D
-
T
--
L
-
T
I
T
--
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
-----
D
D
-
I
R
I
L
R
D
I
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
84.69
34%
-77
- C4 -
4D26
4
?
A:
[49-406]
I
E
S
F
E
T
A
N
L
R
-
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
--
G
--
R
--
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
-
V
P
----
I
I
N
M
L
L
Q
D
P
K
D
L
--
I
--------
S
-------------------
E
-------------------
N
-------
G
-
C
A
Q
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
---
I
F
N
E
A
R
K
F
S
-
Y
G
-
S
----
V
L
---
K
V
-
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
-
I
A
R
-
G
-
C
H
------
I
L
V
A
T
P
G
R
L
H
D
F
V
---
E
R
-
N
-
R
V
S
F
G
--
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
---
D
M
-
G
-
F
M
P
S
I
E
K
M
M
-
L
H
P
T
M
---
V
---
E
T
------
T
------
K
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
-
L
F
--
V
A
V
G
I
V
----
G
----
G
A
S
T
D
V
E
Q
I
F
I
E
V
-
T
-
K
-
Y
-
E
-
K
----
R
----
N
S
L
-------
K
Q
L
I
-
E
-
E
--
N
-
D
G
K
--
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
---
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
------
K
------
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
83.83
35%
-79
- C4 -
2DB3
3
VASA1_DROME
D:
[55-421]
I
Q
H
F
T
S
A
D
L
R
-
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
--
G
--
R
--
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
-
L
P
----
I
L
-------
S
K
L
--
L
EDPHELEL
G
-------------------
R
-------------------
P
-------------
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
---
I
F
N
E
A
R
K
F
A
-
F
E
-
S
----
Y
L
---
K
I
-
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
-
I
T
R
-
G
-
C
H
------
V
V
I
A
T
P
G
R
L
L
D
F
V
---
D
R
-
T
-
F
I
T
F
E
--
D
T
R
F
V
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
---
S
E
D
M
R
-
R
I
M
T
H
---
V
---
T
M
R-----
P
------
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
-
V
F
VA
I
G
I
V
G
G
----
A
----
C
S
D
V
K
-----
Q
T
I
-
Y
-
E
-
V
-
N
-
K
----
Y
----
A
K
R
-------
S
K
L
I
-
E
-
I
LS
E
-
Q
A
D
--
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
---
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
------
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
EKDRA
I
A
-
A
D
L
V
K
I
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
83.81
35%
-80
- C4 -
2DB3
3
VASA1_DROME
C:
[55-421]
I
Q
H
F
T
S
A
D
L
R
-
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
--
G
--
R
--
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
-
L
P
----
I
L
-------
S
K
L
--
L
EDPHELEL
G
-------------------
R
-------------------
P
-------------
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
---
I
F
N
E
A
R
K
F
A
-
F
E
-
S
----
Y
L
---
K
I
-
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
-
I
T
R
-
G
-
C
H
------
V
V
I
A
T
P
G
R
L
L
D
F
V
---
D
R
-
T
-
F
I
T
F
E
--
D
T
R
F
V
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
---
S
E
D
M
R
-
R
I
M
T
H
---
V
---
T
M
R-----
P
------
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
-
V
F
VA
I
G
I
V
G
G
----
A
----
C
S
D
V
K
-----
Q
T
I
-
Y
-
E
-
V
-
N
-
K
----
Y
----
A
K
R
-------
S
K
L
I
-
E
-
I
LS
E
-
Q
A
D
--
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
---
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
------
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
EKDRA
I
A
-
A
D
L
V
K
I
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
83.35
35%
-79
- C4 -
2DB3
3
VASA1_DROME
A:
[55-421]
I
Q
H
F
T
S
A
D
L
R
-
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
--
G
--
R
--
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
-
L
P
----
I
L
-------
S
K
L
--
L
E
DP
H
E
L
E
L
G
-------------------
R
-------------------
P
-------------
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
---
I
F
N
E
A
R
K
F
A
-
F
E
-
S
----
Y
L
---
K
I
-
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
-
I
T
R
-
G
-
C
H
------
V
V
I
A
T
P
G
R
L
L
D
F
V
---
D
R
-
T
-
F
I
T
F
E
--
D
T
R
F
V
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
---
S
E
D
M
R
-
R
I
M
T
H
---
V
---
T
M
R-----
P
------
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
-
V
F
V
A
I
G
I
V
G
G
----
A
----
C
S
D
V
K
-----
Q
T
I
-
Y
-
E
-
V
-
N
-
K
----
Y
----
A
K
R
-------
S
K
L
I
-
E
-
I
L
S
E
-
Q
A
D
--
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
---
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
------
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
EKDRA
I
A
-
A
D
L
V
K
I
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
83.32
33%
-90
- C4 -
4BRW
2
DHH1_YEAST
A:
[3-364]
---
F
E
D
F
Y
L
K
-
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
--
G
--
R
--
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
-
I
P
----
T
L
-------
E
K
V
--
K
--------
P
-------------------
K
-------------------
L
-------
N
K
I
---
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
---
T
S
Q
V
V
R
T
L
G
-
K
H
-
C
----
G
I
---
S
C
-
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
-
L
N
E
-
T
-
V
H
------
I
L
V
G
T
P
G
R
V
L
D
L
A
---
S
R
-
K
-
V
A
D
L
S
--
D
C
S
L
F
I
M
D
E
A
D
K
M
L
---
S
R
-
D
-
F
---
K
T
I
I
E
-
Q
I
L
S
F
---
L
---
P
P
------
T
------
H
-
Q
S
L
L
F
S
A
T
F
P
L
T
V
D
E
F
M
D
K
H
L
H
K
P
-
Y
E
--
I
N
L
M
E
-----
E
----
L
T
L
K
G
I
T
Q
Y
Y
A
F
V
-
E
-
E
-
R
-
Q
-
K
----
L
----
H
C
L
-------
N
T
L
F
-
S
-
K
--
L
-
Q
I
N
--
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
---
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
------
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
-----
N
D
-
R
F
N
L
Y
K
I
E
Q
E
-
L
G
T
E
I
A
A
I
---------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
83.31
32%
-81
- C4 -
3I5X
3
MS116_YEAST
A:
[78-458]
-------
V
L
D
-
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
SE
D
--
H
--
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
-
I
P
----
I
F
-------
Q
H
L
--
I
--------
N
-------------------
T
KFDSQ--------------
Y
-------
M
-
V
---
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
---
I
E
A
E
V
K
K
I
H
-
D
M
N
Y
----
G
L
KKY
A
C
-
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
N
K
L
-
R
-
P
N
------
I
V
I
A
T
P
G
R
L
I
D
V
L
---
E
K
-
Y
S
N
K
F
F
R
--
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
I
-
G
-
F
---
R
D
D
L
E
-
T
I
S
G
I
---
L
---
N
E
------
K
NSKSAD
N
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
-
E
C
--
L
F
L
D
T
V
DKNE
P
----
E
A
H
E
R
I
D
Q
S
V
V
I
S
-
E
-
K
F
A
-
N
-
S
----
I
F
A
A
V
E
H
I
-------
K
K
Q
I
K
E
-
R
--
D
-
S
N
Y
--
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
FKK
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
-----
D
E
-
L
P
F
V
R
E
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
82.87
35%
-80
- C4 -
2DB3
3
VASA1_DROME
B:
[55-421]
I
Q
H
F
T
S
A
D
L
R
-
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
--
G
--
R
--
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
-
L
P
----
I
L
-------
S
K
L
--
L
EDPHELEL
G
-------------------
R
-------------------
P
-------------
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
---
I
F
N
E
A
R
K
F
A
-
F
E
-
S
----
Y
L
---
K
I
-
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
-
I
T
R
-
G
-
C
H
------
V
V
I
A
T
P
G
R
L
L
D
F
V
---
D
R
-
T
-
F
I
T
F
E
--
D
T
R
F
V
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
---
S
E
D
M
R
-
R
I
M
T
H
---
V
---
T
M
R-----
P
------
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
-
V
F
VA
I
G
I
V
G
G
----
A
----
C
S
D
V
K
-----
Q
T
I
-
Y
-
E
-
V
-
N
-
K
----
Y
----
A
K
R
-------
S
K
L
I
-
E
-
I
LS
E
-
Q
A
D
--
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
---
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
------
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
EKDRA
I
A
-
A
D
L
V
K
I
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
82.04
33%
-100
- C4 -
1XTI
4
DX39B_HUMAN
A:
[10-355]
---
F
R
D
F
L
L
K
-
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
--
G
--
M
--
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
-
L
A
----
T
L
-------
Q
Q
L
--
E
--------
P
-------------------
V
-------------------
T
-------
G
Q
V
---
S
V
L
V
M
C
H
T
R
E
L
A
F
Q
---
I
S
K
E
Y
E
R
F
S
-
K
Y
-
M
P---
N
V
---
K
V
-
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
-
L
K
K
-
N
C
P
H
------
I
V
V
G
T
P
G
R
I
L
A
L
A
---
R
N
-
K
-
S
L
N
L
K
--
H
I
K
H
F
I
L
D
E
C
D
K
M
L
E--
Q
L
-
D
-
M
---
R
R
D
V
Q
-
E
I
F
R
M
---
T
---
P
H
-------------
E
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
--
F
V
D
D
E
T
----
K
----
L
T
L
H
G
L
Q
Q
Y
Y
V
K
L
-
K
-
D
-
N
-
E
-
K
----
N
----
R
K
L
-------
F
D
L
L
-
D
-
V
--
L
-
E
F
N
--
Q
V
V
I
F
V
K
S
V
Q
R
C
I
A
L
A
Q
L
L
V
E
Q
---
N
F
P
A
I
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
------
E
------
D
S
D
T
Y
L
H
R
V
A
R
A
G
R
F
G
T
K
G
L
A
I
T
F
V
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
81.83
32%
-87
- C4 -
3FHT
4
DD19B_HUMAN
A:
[25-399]
-
K
S
F
E
E
L
R
L
K
-
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
--
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
-
L
A
----
M
L
-------
S
Q
V
--
E
--------
P
-------------------
A
N------------------
K
-------
Y
-
P
---
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
---
T
G
K
V
I
E
Q
M
G
-
K
F
-
Y
P---
E
L
---
K
L
-
A
Y
A
V
R
G
N
K
---
L
E
R
G
-
Q
K
I
-
S
-
E
Q
------
I
V
I
G
T
P
G
T
V
L
D
W
C
---
S
K
-
L
K
F
I
D
P
K
--
K
I
K
V
F
V
L
D
E
A
D
V
M
I
---
A
T
Q
G
-
H
---
Q
D
Q
S
I
-
R
I
Q
R
M
---
L
---
P
R
-------------
N
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
-
N
V
--
I
K
L
K
R
E
----
E
----
E
T
L
D
T
I
K
Q
Y
Y
V
L
C
-
S
-
S
R
D
-
E
-
K
----
F
----
Q
A
L
-------
C
N
L
Y
-
G
-
A
--
I
-
T
I
A
--
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
------
V
DKDGNP
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
-----
K
H
S
M
N
I
L
N
R
I
Q
E
H
-
F
N
K
K
I
E
R
L
---------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
81.28
33%
-82
- C4 -
3PEY
11
DBP5_YEAST
A:
[5-357]
-
K
S
F
D
E
L
G
L
A
-
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
--
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
-
L
T
----
M
L
-------
T
R
V
--
N
--------
P
-------------------
E
D------------------
A
-------
S
-
P
---
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
---
T
L
E
V
V
Q
E
M
G
-
K
F
-
T
----
K
I
---
T
S
-
Q
L
I
V
P
D
S
F
----
E
K
N
-
K
Q
I
-
N
-
A
Q
------
V
I
V
G
T
P
G
T
V
L
D
L
M
---
R
R
-
K
-
L
M
Q
L
Q
--
K
I
K
I
F
V
L
D
E
A
D
N
M
L
---
D
Q
Q
G
-
L
---
G
D
Q
C
I
-
R
V
K
R
F
---
L
---
P
K
------
D
-------
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
-
N
T
--
L
E
L
Q
T
N
----
E
----
V
N
V
D
A
I
K
Q
L
Y
M
D
C
-
K
N
E
-
A
-
D
-
K
----
F
----
D
V
L
-------
T
E
L
Y
-
G
-
L
--
M
-
T
I
G
--
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
------
T
LANGQA
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
-----
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
81.16
32%
-78
- C4 -
3SQW
3
MS116_YEAST
A:
[26-408]
------
G
V
L
D
-
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
SE
D
--
H
--
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
-
I
P
----
I
F
-------
Q
H
L
--
I
--------
N
-------------------
T
KFDSQ--------------
Y
-------
M
-
V
---
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
---
I
E
A
E
V
K
K
I
H
-
D
M
-
N
YGLK
K
Y
---
A
C
-
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
N
K
L
-
R
-
P
N
------
I
V
I
A
T
P
G
R
L
I
D
V
L
---
E
K
-
Y
S
N
K
F
F
R
--
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
I
-
G
-
F
---
R
D
D
L
E
-
T
I
S
G
I
---
L
---
N
E
K
NSKSA
D
------
N
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
-
E
C
--
L
F
L
D
T
V
----
D
KNEP
E
A
H
E
R
I
D
Q
S
V
V
I
S
-
E
-
K
F
A
-
N
-
S
I
F
A
A
V
----
E
H
I
-------
K
K
Q
I
-
K
E
R
--
D
-
S
N
Y
--
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
FKK
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
-----
D
E
-
L
P
F
V
R
E
L
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
121
HHSearch
81.11
32%
-97
- C4 -
1XTI
4
DX39B_HUMAN
A:
[9-357]
--
G
F
R
D
F
L
L
K
-
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
--
G
--
M
--
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
-
L
A
----
T
L
-------
Q
Q
L
--
E
--------
P
-------------------
V
T------------------
G
-------
Q
-
V
---
S
V
L
V
M
C
H
T
R
E
L
A
F
Q
---
I
S
K
E
Y
E
R
F
S
-
K
Y
M
P
----
N
V
---
K
V
-
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
K
K
N
-
C
-
P
H
------
I
V
V
G
T
P
G
R
I
L
A
L
A
---
R
N
-
K
-
S
L
N
L
K
--
H
I
K
H
F
I
L
D
E
C
D
K
M
L
---
E
Q
L
D
-
M
---
R
R
D
V
Q
-
E
I
F
R
M
---
T
---
P
H
------
E
-------
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
-
M
E
--
I
F
V
D
D
E
T---
K
----
L
T
L
H
G
L
Q
Q
Y
Y
V
K
L
-
K
-
D
-
N
-
E
-
K
----
N
----
R
K
L
-------
F
D
L
L
-
D
-
V
--
L
-
E
F
N
--
Q
V
V
I
F
V
K
S
V
Q
R
C
I
A
L
A
Q
L
L
V
E
Q
---
N
F
P
A
I
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
------
E
------
D
S
D
T
Y
L
H
R
V
A
R
A
G
R
F
G
T
K
G
L
A
I
T
F
V
S
D
-----
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
80.82
31%
-81
- C4 -
3PEY
11
DBP5_YEAST
A:
[5-354]
-
K
S
F
D
E
L
G
L
A
-
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
--
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
-
L
T
----
M
L
-------
T
R
V
--
N
--------
P
-------------------
E
-------------------
D
-------
A
-
S
P--
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
---
T
L
E
V
V
Q
E
M
G
-
K
F
-
T
----
K
I
---
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
N
A
--------
Q
------
V
I
V
G
T
P
G
T
V
L
D
L
M
---
R
R
-
K
-
L
M
Q
L
Q
--
K
I
K
I
F
V
L
D
E
A
D
N
M
L
---
D
Q
-
Q
-
G
---
L
G
D
Q
C
-
I
R
V
K
R
---
F
---
L
P
------
K
------
D
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
-
N
T
--
L
E
L
Q
T
N
----
E
----
V
N
V
D
A
I
K
Q
L
Y
M
D
C
-
K
N
E
-
A
-
D
-
K
----
F
----
D
V
L
-------
T
E
L
Y
-
G
-
L
--
M
-
T
I
G
--
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
TLANGQ
A
------
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
80.65
32%
-82
- C4 -
3PEW
9
DBP5_YEAST
A:
[5-354]
-
K
S
F
D
E
L
G
L
A
-
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
--
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
-
L
T
----
M
L
-------
T
R
V
--
N
--------
P
-------------------
E
-------------------
D
-------
A
-
S
P--
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
---
T
L
E
V
V
Q
E
M
G
-
K
F
-
T
----
K
I
---
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
N
A
--------
Q
------
V
I
V
G
T
P
G
T
V
L
D
L
M
---
R
R
-
K
-
L
M
Q
L
Q
--
K
I
K
I
F
V
L
D
E
A
D
N
M
L
---
D
Q
-
Q
-
G
---
L
G
D
Q
C
-
I
R
V
K
R
---
F
---
L
P
------
K
------
D
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
-
N
T
--
L
E
L
Q
T
N
----
E
----
V
N
V
D
A
I
K
Q
L
Y
M
D
C
-
K
N
E
-
A
-
D
-
K
----
F
----
D
V
L
-------
T
E
L
Y
-
G
-
V
--
M
-
T
I
G
--
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
TLANGQ
A
------
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
80.38
31%
-90
- C4 -
3EWS
1
DD19B_HUMAN
A:
[61-436]
V
K
S
F
E
E
L
R
L
K
-
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
--
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
-
L
A
----
M
L
-------
S
Q
V
E-
P
--------
A
-------------------
N
-------------------
K
-------
Y
-
P
---
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
----
P
----
E
L
---
K
L
-
A
Y
A
V
R
G
N
K
L
E
R
---
G
-
Q
K
I
-
S
-
E
Q
------
I
V
I
G
T
P
G
T
V
L
D
W
C
---
S
K
L
K
-
F
I
D
P
K
--
K
I
K
V
F
V
L
D
E
A
D
V
M
I
---
A
T
-
Q
-
G
---
H
Q
D
Q
S
-
I
R
I
Q
R
---
M
---
L
P
------
R
------
N
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
-
N
V
--
I
K
L
K
R
E
----
E
----
E
T
L
D
T
I
K
Q
Y
Y
V
L
C
-
S
-
S
-
R
D
E
-
K
----
F
----
Q
A
L
-------
C
N
L
Y
-
G
-
A
--
I
-
T
I
A
--
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
D
KDGN
P
------
D
N
E
T
Y
L
H
R
I
G
R
----
G
K
R
G
L
A
V
N
M
V
D
S
-----
K
H
S
M
N
I
L
N
R
I
Q
E
H
-
F
N
K
K
I
E
R
L
---------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
79.52
31%
-84
- C4 -
3FHT
4
DD19B_HUMAN
A:
[24-399]
V
K
S
F
E
E
L
R
L
K
-
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
--
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
-
L
A
----
M
L
-------
S
Q
V
E-
P
--------
A
-------------------
N
-------------------
K
-------
Y
-
P
---
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
----
P
----
E
L
---
K
L
-
A
Y
A
V
R
G
N
K
L
E
R
---
G
-
Q
K
I
-
S
-
E
Q
------
I
V
I
G
T
P
G
T
V
L
D
W
C
---
S
K
L
K
-
F
I
D
P
K
--
K
I
K
V
F
V
L
D
E
A
D
V
M
I
---
A
T
-
Q
-
G
---
H
Q
D
Q
S
-
I
R
I
Q
R
---
M
---
L
P
------
R
------
N
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
-
N
V
--
I
K
L
K
R
E
----
E
----
E
T
L
D
T
I
K
Q
Y
Y
V
L
C
-
S
-
S
-
R
D
E
-
K
----
F
----
Q
A
L
-------
C
N
L
Y
-
G
-
A
--
I
-
T
I
A
--
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
VDKDGN
P
------
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
-----
K
H
S
M
N
I
L
N
R
I
Q
E
H
-
F
N
K
K
I
E
R
L
---------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
79.27
32%
-82
- C4 -
3RRN
2
DBP5_YEAST
A:
[5-354]
-
K
S
F
D
E
L
G
L
A
-
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
--
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
-
L
T
----
M
L
-------
T
R
V
--
N
--------
P
-------------------
E
-------------------
D
-------
A
-
S
P--
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
---
T
L
E
V
V
Q
E
M
G
-
K
F
-
T
----
K
I
---
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
N
A
--------
Q
------
V
I
V
G
T
P
G
T
V
L
D
L
M
---
R
R
-
K
-
L
M
Q
L
Q
--
K
I
K
I
F
V
L
D
E
A
D
N
M
L
---
D
Q
-
Q
-
G
---
L
G
D
Q
C
-
I
R
V
K
R
---
F
---
L
P
------
K
------
D
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
-
N
T
--
L
E
L
Q
--------------
D
A
I
K
Q
L
Y
M
D
C
-
K
N
E
-
A
-
D
-
K
----
F
----
D
V
L
-------
T
E
L
Y
-
G
-
V
--
M
-
T
I
G
--
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
TLANGQ
A
------
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
78.28
32%
-87
- C4 -
3RRM
1
DBP5_YEAST
A:
[11-354]
-------
G
L
A
-
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
--
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
-
L
T
----
M
L
-------
T
R
V
--
N
--------
P
-------------------
E
-------------------
D
-------
A
-
S
P--
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
---
T
L
E
V
V
Q
E
M
G
-
K
F
-
T
----
K
I
---
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
N
A
--------
Q
------
V
I
V
G
T
P
G
T
V
L
D
L
M
---
R
R
-
K
-
L
M
Q
L
Q
--
K
I
K
I
F
V
L
D
E
A
D
N
M
L
---
D
Q
-
Q
-
G
---
L
G
D
Q
C
-
I
R
V
K
R
---
F
---
L
P
------
K
------
D
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
-
N
T
--
L
E
L
------------
V
N
V
D
A
I
K
Q
L
Y
M
D
C
-
K
N
E
-
A
-
D
-
K
----
F
----
D
V
L
-------
T
E
L
Y
-
G
-
V
--
M
-
T
I
G
--
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
------
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
TLANGQ
A
------
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
78.23
31%
-84
- C4 -
3FHT
6
DD19B_HUMAN
B:
[24-399]
V
K
S
F
E
E
L
R
L
K
-
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
--
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
-
L
A
----
M
L
-------
S
Q
V
E-
P
--------
A
-------------------
N
-------------------
K
-------
Y
-
P
---
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
----
P
----
E
L
---
K
L
-
A
Y
A
V
R
G
N
----------
K
I
-
S
-
E
Q
------
I
V
I
G
T
P
G
T
V
L
D
W
C
---
S
K
L
K
-
F
I
D
P
K
--
K
I
K
V
F
V
L
D
E
A
D
V
M
I
---
A
T
-
Q
-
G
---
H
Q
D
Q
S
-
I
R
I
Q
R
---
M
---
L
P
------
R
------
N
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
-
N
V
--
I
K
L
K
R
E
----
E
----
E
T
L
D
T
I
K
Q
Y
Y
V
L
C
-
S
-
S
-
R
D
E
-
K
----
F
----
Q
A
L
-------
C
N
L
Y
-
G
-
A
--
I
-
T
I
A
--
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
VDKDGN
P
------
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
-----
K
H
S
M
N
I
L
N
R
I
Q
E
H
-
F
N
K
K
I
E
R
L
---------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
77.82
31%
-82
- C4 -
3G0H
4
DD19B_HUMAN
A:
[40-415]
V
K
S
F
E
E
L
R
L
K
-
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
--
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
-
L
A
----
M
L
-------
S
Q
V
E-
P
--------
A
-------------------
N
-------------------
K
-------
Y
-
P
---
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
----
P
----
E
L
---
K
L
-
A
Y
A
V
R
G
N
K
L
E
R
---
G
-
Q
K
I
-
S
-
E
Q
------
I
V
I
G
T
P
G
T
V
L
D
W
C
---
S
K
L
K
-
F
I
D
P
K
--
K
I
K
V
F
V
L
D
E
A
D
V
M
I
---
A
T
-
Q
-
G
---
H
Q
D
Q
S
-
I
R
I
Q
R
---
M
---
L
P
------
R
------
N
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
-
N
V
--
I
K
L
K
R
E
----
E
----
E
T
L
D
T
I
K
Q
Y
Y
V
L
C
-
S
-
S
-
R
D
E
-
K
----
F
----
Q
A
L
-------
C
N
L
Y
-
G
-
A
--
I
-
T
I
A
--
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
VDKDGN
P
------
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
-----
K
H
S
M
N
I
L
N
R
I
Q
E
H
-
F
N
K
K
I
E
R
L
---------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
70.43
39%
-101
- C4 -
3MWL
2
?
B:
[2-207]
--
E
F
K
D
F
P
L
K
-
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
--
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
-
L
P
----
I
A
-------
E
R
L
--
A
--------
P
-------------------
S
-------------------
Q
ERGR---
K
-
P
---
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
A
----
P
----
H
L
---
K
V
-
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
-
L
L
R
-
G
-
A
D
------
A
V
V
A
T
P
G
R
A
L
D
Y
L
---
R
Q
-
G
-
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
---
E
E
E
V
E
-
A
L
L
S
A
---
T
---
P
P
-------------
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
-
V
L
--
I
N
V
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
70.30
39%
-98
- C4 -
3NBF
4
?
C:
[2-207]
--
E
F
K
D
F
P
L
K
-
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
--
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
-
L
P
----
I
A
-------
E
R
L
--
A
--------
P
-------------------
S
-------------------
Q
ERG
R
---
K
-
P
---
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
A
----
P
----
H
L
---
K
V
-
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
-
L
L
R
-
G
-
A
D
------
A
V
V
A
T
P
G
R
A
L
D
Y
L
---
R
Q
-
G
-
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
---
E
E
E
V
E
-
A
L
L
S
A
---
T
---
P
P
-------------
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
-
V
L
--
I
N
V
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
69.84
39%
-96
- C4 -
2GXS
4
?
B:
[2-207]
--
E
F
K
D
F
P
L
K
-
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
--
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
-
L
P
----
I
A
-------
E
R
L
--
A
--------
P
-------------------
S
-------------------
Q
ERGR---
K
-
P
---
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
A
----
P
----
H
L
---
K
V
-
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
-
L
L
R
-
G
-
A
D
------
A
V
V
A
T
P
G
R
A
L
D
Y
L
---
R
Q
-
G
-
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
---
E
E
E
V
E
-
A
L
L
S
A
---
T
---
P
P
-------------
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
-
V
L
--
I
N
V
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
69.48
36%
-100
- C4 -
4PX9
1
DDX3X_HUMAN
A:
[64-282]
I
E
S
F
S
D
V
E
M
G
-
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
--
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
-
L
P
----
I
L
-------
S
Q
I
--
Y
--------
S
D
GPGEALRAMKENGRYG
R
R
K
-------------------
Q
-------
Y
-
P
---
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
---
I
Y
E
E
A
R
K
F
S
-
Y
R
-
S
----
R
V
---
R
P
-
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
-
L
E
R
-
G
-
C
H
------
L
L
V
A
T
P
G
R
L
V
D
M
M
---
E
R
-
G
-
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
---
E
P
Q
I
R
-
R
I
V
E
Q
DTM
P
---
P
K
------
G
------
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
69.42
36%
-100
- C4 -
4PX9
1
DDX3X_HUMAN
B:
[64-282]
I
E
S
F
S
D
V
E
M
G
-
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
--
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
-
L
P
----
I
L
-------
S
Q
I
--
Y
--------
S
D
GPGEALRAMKENGRYG
R
R
K
-------------------
Q
-------
Y
-
P
---
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
---
I
Y
E
E
A
R
K
F
S
-
Y
R
-
S
----
R
V
---
R
P
-
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
-
L
E
R
-
G
-
C
H
------
L
L
V
A
T
P
G
R
L
V
D
M
M
---
E
R
-
G
-
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
---
E
P
Q
I
R
-
R
I
V
E
Q
DTM
P
---
P
K
------
G
------
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
69.24
39%
-94
- C4 -
3NBF
2
?
A:
[2-207]
--
E
F
K
D
F
P
L
K
-
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
--
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
-
L
P
----
I
A
-------
E
R
L
--
A
--------
P
-------------------
S
-------------------
Q
ERGR---
K
-
P
---
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
A
----
P
----
H
L
---
K
V
-
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
-
L
L
R
-
G
-
A
D
------
A
V
V
A
T
P
G
R
A
L
D
Y
L
---
R
Q
-
G
-
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
---
E
E
E
V
E
-
A
L
L
S
A
---
T
---
P
P
-------------
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
-
V
L
--
I
N
V
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
69.14
36%
-100
- C4 -
4PX9
1
DDX3X_HUMAN
C:
[64-282]
I
E
S
F
S
D
V
E
M
G
-
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
--
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
-
L
P
----
I
L
-------
S
Q
I
--
Y
--------
S
DGPGEALRAMKENGRYGRR
K
-------------------
Q
-------
Y
-
P
---
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
---
I
Y
E
E
A
R
K
F
S
-
Y
R
-
S
----
R
V
---
R
P
-
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
-
L
E
R
-
G
-
C
H
------
L
L
V
A
T
P
G
R
L
V
D
M
M
---
E
R
-
G
-
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
---
E
P
Q
I
R
-
R
I
V
E
Q
DTM
P
---
P
K
------
G
------
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
69.08
39%
-95
- C4 -
3MWK
2
?
B:
[2-207]
--
E
F
K
D
F
P
L
K
-
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
--
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
-
L
P
----
I
A
-------
E
R
L
--
A
--------
P
-------------------
S
-------------------
Q
ERGR---
K
-
P
---
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
A
----
P
----
H
L
---
K
V
-
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
-
L
L
R
-
G
-
A
D
------
A
V
V
A
T
P
G
R
A
L
D
Y
L
---
R
Q
-
G
-
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
---
E
E
E
V
E
-
A
L
L
S
A
---
T
---
P
P
-------------
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
-
V
L
--
I
N
V
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
68.96
39%
-99
- C4 -
3FE2
3
DDX5_HUMAN
A:
[30-230]
--
N
F
Y
E
A
N
F
P
-
A
N
V
M
D
V
I
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
V
A
L
S
--
G
--
L
--
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
-
L
P
----
A
I
-------
V
H
I
--
N
--------
H
-------------------
Q
PFLERG-------------
D
-------
G
-
P
---
I
C
L
V
L
A
P
T
R
E
L
A
Q
Q
---
V
Q
Q
V
A
A
E
Y
C
-
R
A
-
C
----
R
L
---
K
S
-
T
C
I
Y
G
G
A
P
K
G
P
Q
I
R
D
-
L
E
R
-
G
-
V
E
------
I
C
I
A
T
P
G
R
L
I
D
F
L
---
E
C
-
G
-
K
T
N
L
R
--
R
T
T
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
---
E
P
Q
I
R
-
K
I
V
D
Q
---
I
---
R
P
-------------
D
R
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
68.88
39%
-91
- C4 -
3NBF
2
?
B:
[2-207]
--
E
F
K
D
F
P
L
K
-
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
--
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
-
L
P
----
I
A
-------
E
R
L
--
A
--------
P
-------------------
S
-------------------
Q
ERGR---
K
-
P
---
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
A
----
P
----
H
L
---
K
V
-
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
-
L
L
R
-
G
-
A
D
------
A
V
V
A
T
P
G
R
A
L
D
Y
L
---
R
Q
-
G
-
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
---
E
E
E
V
E
-
A
L
L
S
A
---
T
---
P
P
-------------
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
-
V
L
--
I
N
V
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
68.78
39%
-96
- C4 -
3FE2
4
DDX5_HUMAN
B:
[30-230]
--
N
F
Y
E
A
N
F
P
-
A
N
V
M
D
V
I
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
V
A
L
S
--
G
--
L
--
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
-
L
P
----
A
I
-------
V
H
I
--
N
--------
H
-------------------
Q
PFLERG-------------
D
-------
G
-
P
---
I
C
L
V
L
A
P
T
R
E
L
A
Q
Q
---
V
Q
Q
V
A
A
E
Y
C
-
R
A
-
C
----
R
L
---
K
S
-
T
C
I
Y
G
G
A
P
K
G
P
Q
I
R
D
-
L
E
R
-
G
-
V
E
------
I
C
I
A
T
P
G
R
L
I
D
F
L
---
E
C
-
G
-
K
T
N
L
R
--
R
T
T
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
---
E
P
Q
I
R
-
K
I
V
D
Q
---
I
---
R
P
-------------
D
R
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
68.62
42%
-93
- C4 -
3BER
4
DDX47_HUMAN
A:
[43-242]
-
K
T
F
K
D
L
G
V
T
-
D
V
L
C
E
A
C
D
Q
L
G
W
T
K
P
T
K
I
Q
I
E
A
I
P
L
A
L
Q
--
G
--
R
--
D
I
I
G
L
A
E
T
G
S
G
K
T
G
A
F
A
-
L
P
----
I
L
-------
N
A
L
--
L
E
-------
T
-------------------
P
-------------------
Q
-------
R
-
L
---
F
A
L
V
L
T
P
T
R
E
L
A
F
Q
---
I
S
E
Q
F
E
A
L
G
-
S
S
-
I
----
G
V
---
Q
S
-
A
V
I
V
G
G
I
D
S
M
S
Q
S
L
A
-
L
A
K
-
K
-
P
H
------
I
I
I
A
T
P
G
R
L
I
D
H
L
E
--
N
T
-
K
-
G
F
N
L
R
--
A
L
K
Y
L
V
M
D
E
A
D
R
I
L
---
N
M
-
D
-
F
---
E
T
E
V
D
-
K
I
L
K
V
---
I
---
P
R
-------------
D
R
K
T
F
L
F
S
A
T
M
T
K
K
V
Q
K
L
Q
R
A
A
L
K
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
68.27
39%
-101
- C4 -
3NBF
2
?
D:
[2-206]
--
E
F
K
D
F
P
L
K
-
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
--
D
L
I
G
Q
A
----
G
K
T
L
A
F
A
-
L
P
----
I
A
-------
E
R
L
--
A
--------
P
-------------------
S
-------------------
Q
ERGR---
K
-
P
---
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
A
----
P
----
H
L
---
K
V
-
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
-
L
L
R
-
G
-
A
D
------
A
V
V
A
T
P
G
R
A
L
D
Y
L
---
R
Q
-
G
-
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
---
E
E
E
V
E
-
A
L
L
S
A
---
T
---
P
P
-------------
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
-
V
L
--
I
N
V
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
67.14
35%
-102
- C4 -
1VEC
1
DDX6_HUMAN
B:
[5-202]
---
F
E
D
Y
C
L
K
-
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
--
G
--
R
--
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
-
I
P
----
L
L
-------
E
R
L
D-
L
--------
K
-------------------
K
-------------------
D
-------
N
-
I
---
Q
A
M
V
I
V
P
T
R
E
L
A
L
Q
---
V
S
Q
I
C
I
Q
V
S
-
K
H
-
M
G---
G
A
---
K
V
-
M
A
T
T
G
G
T
N
L
R
D
D
I
M
R
-
L
D
D
-
T
-
V
H
------
V
V
I
A
T
P
G
R
I
L
D
L
I
---
K
K
-
G
-
V
A
K
V
D
--
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
---
S
Q
-
D
-
F
---
V
Q
I
M
E
-
D
I
I
L
T
---
L
---
P
K
-------------
N
R
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
E
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
66.30
34%
-92
- C4 -
1T6N
1
DX39B_HUMAN
B:
[16-215]
---
F
R
D
F
L
L
K
-
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
--
G
--
M
--
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
-
L
A
----
T
L
-------
Q
Q
L
--
E
--------
P
-------------------
V
-------------------
T
-------
G
Q
V
---
S
V
L
V
M
C
H
T
R
E
L
A
F
Q
---
I
S
K
E
Y
E
R
F
S
-
K
Y
-
M
P---
N
V
---
K
V
-
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
-
L
K
K
N
C
-
P
H
------
I
V
V
G
T
P
G
R
I
L
A
L
A
---
R
N
-
K
-
S
L
N
L
K
--
H
I
K
H
F
I
L
D
E
C
D
K
M
L
E--
Q
L
-
D
-
M
---
R
R
D
V
Q
-
E
I
F
R
M
---
T
---
P
H
-------------
E
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
66.16
34%
-90
- C4 -
1T6N
1
DX39B_HUMAN
A:
[16-215]
---
F
R
D
F
L
L
K
-
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
--
G
--
M
--
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
-
L
A
----
T
L
-------
Q
Q
L
--
E
--------
P
-------------------
V
-------------------
T
-------
G
Q
V
---
S
V
L
V
M
C
H
T
R
E
L
A
F
Q
---
I
S
K
E
Y
E
R
F
S
-
K
Y
-
M
P---
N
V
---
K
V
-
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
-
L
K
K
N
C
-
P
H
------
I
V
V
G
T
P
G
R
I
L
A
L
A
---
R
N
-
K
-
S
L
N
L
K
--
H
I
K
H
F
I
L
D
E
C
D
K
M
L
E
--
Q
L
-
D
-
M
---
R
R
D
V
Q
-
E
I
F
R
M
---
T
---
P
H
-------------
E
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
65.64
33%
-92
- C4 -
2OXC
1
DDX20_HUMAN
A:
[25-227]
--
D
F
E
S
L
L
L
S
-
R
P
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
--
G
--
L
--
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
----
L
D
-------
S
L
V
--
L
--------
E
-------------------
N
-------------------
L
-------
S
-
T
---
Q
I
L
I
L
A
P
T
R
E
I
A
V
Q
---
I
H
S
V
I
T
A
I
G
I
K
M
-
E
----
G
L
---
E
C
-
H
V
F
I
G
G
T
P
L
S
Q
D
K
T
R
-
L
K
K
-
C
--
H
------
I
A
V
G
S
P
G
R
I
K
Q
L
I
---
E
L
-
D
-
Y
L
N
P
G
--
S
I
R
L
F
I
L
D
E
A
D
K
L
L
---
E
E
-
G
S
F
---
Q
E
Q
I
N
-
W
I
Y
S
S
---
L
---
P
A
-------------
S
K
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
-
T
F
--
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
65.58
33%
-97
- C4 -
3B7G
1
DDX20_HUMAN
B:
[25-227]
--
D
F
E
S
L
L
L
S
-
R
P
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
--
G
--
L
--
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
----
L
D
-------
S
L
V
--
L
--------
E
-------------------
N
-------------------
L
-------
S
-
T
---
Q
I
L
I
L
A
P
T
R
E
I
A
V
Q
---
I
H
S
V
I
T
A
I
G
I
K
M
-
E
----
G
L
---
E
C
-
H
V
F
I
G
G
T
P
L
S
Q
D
K
T
R
-
L
K
K
-
C
--
H
------
I
A
V
G
S
P
G
R
I
K
Q
L
I
---
E
L
-
D
-
Y
L
N
P
G
--
S
I
R
L
F
I
L
D
E
A
D
K
L
L
---
E
E
-
G
S
F
---
Q
E
Q
I
N
-
W
I
Y
S
S
---
L
---
P
A
-------------
S
K
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
-
T
F
--
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
65.26
33%
-93
- C4 -
3B7G
1
DDX20_HUMAN
A:
[25-227]
--
D
F
E
S
L
L
L
S
-
R
P
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
--
G
--
L
--
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
----
L
D
-------
S
L
V
--
L
--------
E
-------------------
N
-------------------
L
-------
S
-
T
---
Q
I
L
I
L
A
P
T
R
E
I
A
V
Q
---
I
H
S
V
I
T
A
I
G
I
K
M
-
E
----
G
L
---
E
C
-
H
V
F
I
G
G
T
P
L
S
Q
D
K
T
R
-
L
K
K
-
C
--
H
------
I
A
V
G
S
P
G
R
I
K
Q
L
I
---
E
L
-
D
-
Y
L
N
P
G
--
S
I
R
L
F
I
L
D
E
A
D
K
L
L
---
E
E
-
G
S
F
---
Q
E
Q
I
N
-
W
I
Y
S
S
---
L
---
P
A
-------------
S
K
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
-
T
F
--
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
64.92
33%
-94
- C4 -
2OXC
1
DDX20_HUMAN
B:
[25-227]
--
D
F
E
S
L
L
L
S
-
R
P
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
--
G
--
L
--
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
----
L
D
-------
S
L
V
--
L
--------
E
-------------------
N
-------------------
L
-------
S
-
T
---
Q
I
L
I
L
A
P
T
R
E
I
A
V
Q
---
I
H
S
V
I
T
A
I
G
I
K
M
-
E
----
G
L
---
E
C
-
H
V
F
I
G
G
T
P
L
S
Q
D
K
T
R
-
L
K
K
-
C
--
H
------
I
A
V
G
S
P
G
R
I
K
Q
L
I
---
E
L
-
D
-
Y
L
N
P
G
--
S
I
R
L
F
I
L
D
E
A
D
K
L
L
---
E
E
-
G
S
F
---
Q
E
Q
I
N
-
W
I
Y
S
S
---
L
---
P
A
-------------
S
K
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
-
T
F
--
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
64.38
35%
-99
- C4 -
2PL3
5
DDX10_HUMAN
A:
[27-230]
---
F
S
D
F
P
L
S
-
K
K
T
L
K
G
L
Q
E
A
Q
Y
R
L
V
T
E
I
Q
K
Q
T
I
G
L
A
L
Q
--
G
--
K
--
D
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
-
V
P
----
V
L
-------
E
A
L
--
Y
--------
R
-------------------
L
-------------------
Q
WTSTD--
G
-
L
---
G
V
L
I
I
S
P
T
R
E
L
A
Y
Q
---
T
F
E
V
L
R
K
V
G
-
K
N
-
H
----
D
F
---
S
A
-
G
L
I
I
G
G
--
L
K
H
E
A
E
R
-
I
-
N
-
N
-
I
N
------
I
L
V
C
T
P
G
R
L
L
Q
H
M
---
D
E
-
T
V
S
F
H
A
T
--
D
L
Q
M
L
V
L
D
E
A
D
R
I
L
---
D
M
-
G
-
F
---
A
D
T
M
N
-
A
V
I
E
N
---
L
---
P
K
-------------
K
R
Q
T
L
L
F
S
A
T
Q
T
K
S
V
K
D
L
A
R
L
S
L
K
N
P
-
E
Y
--
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
62.22
35%
-102
- C4 -
3IUY
2
DDX53_HUMAN
A:
[30-226]
------------
D
L
L
K
S
I
I
R
V
G
I
L
K
P
T
P
I
Q
S
Q
A
W
P
I
I
L
Q
--
G
--
I
--
D
L
I
V
V
A
Q
T
G
T
G
K
T
L
S
Y
L
-
M
P
G
F
I
H
L
D
--------------------------------------------------------------N------
G
-
P
---
G
M
L
V
L
T
P
T
R
E
L
A
L
H
---
V
E
A
E
C
S
K
Y
S
-
Y
--
K
----
G
L
---
K
S
-
I
C
I
Y
G
------
Q
I
E
D
-
I
S
K
-
G
-
V
D
------
I
I
I
A
T
P
G
R
L
N
D
L
Q
---
M
N
-
N
-
S
V
N
L
R
--
S
I
T
Y
L
V
I
D
E
A
D
K
M
L
---
D
M
-
E
-
F
---
E
P
Q
I
R
K
I
L
L
D
V
---
R
---
P
--------------
D
R
Q
T
V
M
T
S
A
T
W
P
D
T
V
R
Q
L
A
L
S
Y
L
K
D
P
-
M
I
--
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
60.67
31%
-83
- C4 -
3FMO
1
DD19B_HUMAN
B:
[91-296]
V
K
S
F
E
E
L
R
L
K
-
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
--
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
-
L
A
----
M
L
-------
S
Q
V
E-
P
--------
A
-------------------
N
-------------------
K
-------
Y
-
P
---
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
----
P
----
E
L
---
K
L
-
A
Y
A
V
R
G
N
K
L
E
R
---
G
-
Q
K
I
-
S
-
E
Q
------
I
V
I
G
T
P
G
T
V
L
D
W
C
---
S
K
L
K
-
F
I
D
P
K
--
K
I
K
V
F
V
L
D
E
A
D
V
M
I
---
A
T
-
Q
-
G
---
H
Q
D
Q
S
-
I
R
I
Q
R
---
M
---
L
P
------
R
------
N
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
-
N
V
--
I
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
59.72
35%
-101
- C4 -
3IUY
2
DDX53_HUMAN
B:
[30-226]
------------
D
L
L
K
S
I
I
R
V
G
I
L
K
P
T
P
I
Q
S
Q
A
W
P
I
I
L
Q
--
G
--
I
--
D
L
I
V
V
A
Q
T
G
T
G
K
T
L
S
Y
L
-
M
P
G
F
I
H
L
D
-------
S
------------------------------------------------------N------
G
-
P
---
G
M
L
V
L
T
P
T
R
E
L
A
L
H
---
V
E
A
E
C
S
K
Y
S
-
Y
--
K
----
G
L
---
K
S
-
I
C
I
Y
G
-----------------
V
D
------
I
I
I
A
T
P
G
R
L
N
D
L
Q
---
M
N
-
N
-
S
V
N
L
R
--
S
I
T
Y
L
V
I
D
E
A
D
K
M
L
---
D
M
-
E
-
F
---
E
P
Q
I
R
K
I
L
L
D
V
---
R
---
P
--------------
D
R
Q
T
V
M
T
S
A
T
W
P
D
T
V
R
Q
L
A
L
S
Y
L
K
D
P
-
M
I
--
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
58.41
32%
-80
- C4 -
3DKP
4
DDX52_HUMAN
A:
[32-220]
----
Q
E
Y
K
I
N
-
S
R
L
L
Q
N
I
L
D
A
G
F
Q
M
P
T
P
I
Q
M
Q
A
I
P
V
M
L
H
--
G
--
R
--
E
L
L
A
S
A
P
T
G
S
G
K
T
L
A
F
S
-
I
P
----
I
L
-------
M
Q
L
KQ
P
--------
A
-------------------
N
-------------------
K
-------
G
-
F
---
R
A
L
I
I
S
P
T
R
E
L
A
S
Q
---
I
H
R
E
L
I
K
I
S
-
E
G
-
T
----
G
F
---
R
I
-
H
M
I
H
-----
K
A
A
V
A
A
-
K
K
F
-
G
-
P
K
SSKKF
D
I
L
V
T
T
P
N
R
L
I
Y
L
L
---
K
Q
-
D
-
P
P
G
I
D
LA
S
V
E
W
L
V
V
D
E
S
D
K
L
F
E
D
G---
G
-
F
---
R
D
Q
L
A
-
S
I
F
L
A
---
C
---
T
S
------
H
------
K
V
R
R
A
M
F
S
A
T
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------