@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1887: (2016-03-29 )
MTKENICIVFGGKSAEHEVSILTAQNVLNAIDKDKYHVDIIYITNDGDWRKQNNITAEIKSTDELHLENGEALEISQLLKESSSGQPYDAVFPLLHGPNGEDGTIQGLFEVLDVPYVGNGVLSAASSMDKLVMKQLFEHRGLPQLPYISFLRSEYEKYEHNILKLVNDKLNYPVFVKPANLGSSVGISKCNNEAELKEGIKEAFQFDRKLVIEQGVNAREIEVAVLGNDYPEATWPGEVVKDVAFYDYKSKYKDGKVQLQIPADLDEDVQLTLRNMALEAFKATDCSGLVRADFFVTEDNQIYINETNAMPGFTAFSMYPKLWENMGLSYPELITKLIELAKERHQDKQKNKYKID
Atome Classification :
(57 SA)
.........10........20........30..---.-..-...40......----------..50--------....--..------..------.60----------..----.---------.------.--------.--.-.--70.......-------.80--.---......------------.---.90........100.......110.......120.......130.......-140........150.......160.......170.......180.......190.......200.......210....-.-.-.220.......-230-----........240---..-----.......250..--.-.--.-.-------.260.......270.......280.......290.......300.......310.......320.......330.......340.......350....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTKE
N
I
C
I
V
FGGKSAE
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
IDK---D-
K
Y
-
H
V
D
I
I
Y
I
TNDG----------DWR---------KQNN--
I
T
------
A
E
------IKS----------T
D
----
E
---------
L
------H--------L--E-N--GE
A
L
E
I
S
Q
L
-------
L
K
---E---SSSGQP------------
Y
---
D
A
V
F
P
L
L
HGPNGED
G
T
I
Q
G
L
F
E
VLDVPYVG
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H-R-GLPQ
L
P
Y
I
S
F
L
R
S
E
Y
E
K
Y
E
H
N
I
L
K
L
V
NDKLNY
P
V
F
V
K
PANLGSSVGISKCN
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
QGV-N-
A
-
R
E
I
E
V
A
V
LGND-YP------EATW
P
G
E
V
V
-----
K
D
-----
V
A
F
Y
D
Y
K
SKYKD--
G
-
K
--
V
-
Q
-------
L
Q
IPADLD
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
FKATDCSG
L
V
R
A
D
F
F
V
TED
N
Q
I
Y
I
NETNAMPG
F
T
A
F
S
M
Y
P
K
L
W
E
NMGLS
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
KQKNKYKID
23
PsiBlast_CBE
99.12
100%
-104
- C1 -
2I80
1
DDL_STAAC
B:
[3-356]
--
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
D
K
---
D
-
K
Y
-
H
V
D
I
I
Y
I
T
N
D
G
----------
D
W
R
---------
K
Q
N
N
--
I
T
------
A
E
------
I
K
S
----------
T
D
----
E
---------
L
------
H
--------
L
--
E
-
N
--
G
E
A
L
E
I
S
Q
L
-------
L
K
---
E
---
S
S
S
G
Q
P
------------
Y
---
D
A
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
-
R
-
G
L
P
Q
L
P
Y
I
S
F
L
R
S
E
Y
E
K
Y
E
H
N
I
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
-
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
-----
V
A
F
----------------
V
-
Q
-------
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
K
I
D
21
PsiBlast_CBE
98.83
100%
-106
- C1 -
2I8C
3
DDL_STAAC
B:
[3-356]
--
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
D
K
---
D
-
K
Y
-
H
V
D
I
I
Y
I
T
N
D
G
----------
D
W
R
---------
K
Q
N
N
--
I
T
------
A
E
------
I
K
S
----------
T
D
----
E
---------
L
------
H
--------
L
--
E
-
N
--
G
E
A
L
E
I
S
Q
L
-------
L
K
---
E
---
S
S
S
G
Q
P
------------
Y
---
D
A
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
-
R
-
G
L
P
Q
L
P
Y
I
S
F
L
R
S
E
Y
E
K
Y
E
H
N
I
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
-
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
-----
V
A
F
----------------
V
-
Q
-------
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
K
I
D
2
PsiBlast_PDB
98.48
100%
-103
- C1 -
2I87
1
DDL_STAAC
A:
[3-356]
--
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
D
K
---
D
-
K
Y
-
H
V
D
I
I
Y
I
T
N
D
G
----------
D
W
R
---------
K
Q
N
N
--
I
T
------
A
E
------
I
K
S
----------
T
D
----
E
---------
L
------
H
--------
L
--
E
-
N
--
G
E
A
L
E
I
S
Q
L
-------
L
K
---
E
---
S
S
S
G
Q
P
------------
Y
---
D
A
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
-
R
-
G
L
P
Q
L
P
Y
I
S
F
L
R
S
E
Y
E
K
Y
E
H
N
I
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
-
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
-----
V
A
F
----------------
V
-
Q
-------
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
K
I
D
22
PsiBlast_CBE
98.15
100%
-105
- C1 -
2I87
1
DDL_STAAC
B:
[3-356]
--
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
D
K
---
D
-
K
Y
-
H
V
D
I
I
Y
I
T
N
D
G
----------
D
W
R
---------
K
Q
N
N
--
I
T
------
A
E
------
I
K
S
----------
T
D
----
E
---------
L
------
H
--------
L
--
E
-
N
--
G
E
-
L
E
I
S
Q
L
-------
L
K
---
E
---
S
S
S
G
Q
P
------------
Y
---
D
A
V
F
P
L
L
H
G
P
--
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
-
R
-
G
L
P
Q
L
P
Y
I
S
F
L
R
S
E
Y
E
K
Y
E
H
N
I
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
-
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
-----
V
A
F
----------------
V
-
Q
-------
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
K
I
D
1
PsiBlast_PDB
97.13
100%
-102
- C1 -
2I80
1
DDL_STAAC
A:
[3-356]
--
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
D
K
---
D
-
K
Y
-
H
V
D
I
I
Y
I
T
N
D
G
----------
D
W
R
---------
K
Q
N
N
--
I
T
------
A
E
------
I
K
S
----------
T
D
----
E
---------
L
------
H
--------
L
--
E
-
N
--
G
E
A
L
E
I
S
Q
L
-------
L
K
---
E
---
S
S
S
G
Q
P
------------
Y
---
D
A
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
-
R
-
G
L
P
Q
L
P
Y
I
S
F
L
R
S
E
Y
E
K
Y
E
H
N
I
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
-
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
-----
V
A
F
----------------
V
-
Q
-------
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
K
I
D
3
PsiBlast_PDB
96.97
100%
-103
- C1 -
2I8C
2
DDL_STAAC
A:
[3-356]
--
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
D
K
---
D
-
K
Y
-
H
V
D
I
I
Y
I
T
N
D
G
----------
D
W
R
---------
K
Q
N
N
--
I
T
------
A
E
------
I
K
S
----------
T
D
----
E
---------
L
------
H
--------
L
--
E
-
N
--
G
E
A
L
E
I
S
Q
L
-------
L
K
---
E
---
S
S
S
G
Q
P
------------
Y
---
D
A
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
-
R
-
G
L
P
Q
L
P
Y
I
S
F
L
R
S
E
Y
E
K
Y
E
H
N
I
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
-
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
-----
V
A
F
----------------
V
-
Q
-------
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
K
I
D
69
HHSearch
95.42
97%
-98
- C1 -
2I87
1
DDL_STAAC
A:
[3-356]
--
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
D
K
---
D
-
K
Y
-
H
V
D
I
I
Y
I
T
N
D
G
----------
D
W
R
---------
K
Q
N
N
--
I
T
AEIKST
D
E
L-----
H
L
E
----------
N
G
---------------------
E
--------
A
-------
L
E
I
S
---
Q
L
-------
L
K
---
E
---
S
S
S
G
Q
P
------------
Y
---
D
A
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
-
R
-
G
L
P
Q
L
P
Y
I
S
F
L
R
S
E
Y
E
K
Y
E
H
N
I
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
-
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
-----
V
A
F
----------------
V
-
Q
-------
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
K
I
D
75
HHSearch
75.18
41%
-88
- C1 -
3E5N
-
?
A:
[2-360]
-
R
K
I
R
V
G
L
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
D
A
L
D
P
---
Q
-
R
F
-
E
P
V
L
I
G
I
D
K
Q
G
----------
Q
W
H
---------
V
N
D
P
DS
F
L
------
L
H
------
A
D
D
----------
P
A
----
R
I
A
L
HRSGR
G
V
------
A
--------
L
--
L
-
P
--
G
A
Q
Q
---
Q
Q
-------
L
R
PIQ-----
Q
A
L
A
Q
------------
I
---
D
V
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
R
D
-
A
-
R
L
A
V
A
P
F
V
C
F
D
R
H
T
A
A
H
---
A
D
V
D
T
L
I
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
-
A
-
G
-
R
E
I
E
C
A
V
L
G
N
A
-
V
P
------
H
A
S
V
C
G
E
V
V
-----
V
---------------------------
E
-------
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
L
L
-----
76
HHSearch
72.07
48%
-87
- C1 -
3K3P
-
DDL_STRMU
A:
[3-346]
--
K
E
T
L
V
L
L
Y
G
G
R
S
A
E
R
D
V
S
V
L
S
A
E
S
V
M
R
A
I
N
Y
---
D
-
N
F
-
L
V
K
T
Y
F
I
T
Q
A
G
----------
D
F
I
---------
K
T
Q
E
--
F
D
------
S
Q
PS------
D
----------
K
L
----
M
---------
T
------
N
-----------
D
-
T
--
I
I
A
S
---
Q
K
-------
I
K
---
P
---
S
D
I
Y
E
E
------------
E
---
A
V
V
F
P
V
L
H
G
P
M
G
E
D
G
S
I
Q
G
F
L
E
V
L
K
M
P
Y
V
G
T
N
I
L
S
S
S
V
A
M
D
K
I
T
T
N
Q
V
L
E
S
-
A
T
T
I
P
Q
V
A
Y
V
A
L
I
E
G
E
P
L
E
---
S
K
L
A
E
V
E
E
K
L
I
Y
P
V
F
V
K
P
A
N
------
I
S
K
A
E
N
R
T
D
L
K
Q
A
I
A
L
A
L
K
Y
D
S
R
V
L
I
E
Q
G
V
-
D
-
A
-
R
E
I
E
V
G
I
L
G
N
T
-
D
V
------
K
T
T
L
P
G
E
I
V
---------------------------------
T
-------
M
A
I
P
A
E
I
D
P
V
I
V
E
K
M
R
D
Y
A
A
T
A
F
R
T
L
G
C
C
G
L
S
R
C
D
F
F
L
T
E
D
G
K
V
Y
L
N
E
L
N
T
M
P
G
F
T
--
S
M
Y
P
L
L
W
E
N
M
G
L
S
Y
S
V
L
I
E
E
L
V
S
L
A
K
E
M
F
D
K
R
E
S
------
4
PsiBlast_PDB
71.73
47%
-88
- C1 -
3K3P
-
DDL_STRMU
A:
[3-346]
--
K
E
T
L
V
L
L
Y
G
G
R
S
A
E
R
D
V
S
V
L
S
A
E
S
V
M
R
A
I
N
Y
---
D
-
N
F
-
L
V
K
T
Y
F
I
T
Q
A
G
----------
D
F
I
---------
K
T
Q
E
--
F
D
------
S
Q
------
P
S
------------
D
----
K
---------
L
------
M
-------------
T
--
N
D
T
I
I
A
S
Q
K
-------
I
K
---
P
---
S
D
I
Y
E
E
------------
E
---
A
V
V
F
P
V
L
H
G
P
M
G
E
D
G
S
I
Q
G
F
L
E
V
L
K
M
P
Y
V
G
T
N
I
L
S
S
S
V
A
M
D
K
I
T
T
N
Q
V
L
E
S
A
T
-
T
I
P
Q
V
A
Y
V
A
L
I
--
E
G
E
P
L
E
S
K
L
A
E
-
V
E
E
K
L
I
Y
P
V
F
V
K
P
A
N
------
I
S
K
A
E
N
R
T
D
L
K
Q
A
I
A
L
A
L
K
Y
D
S
R
V
L
I
E
Q
G
V
-
D
-
A
-
R
E
I
E
V
G
I
L
G
N
T
-
D
V
------
K
T
T
L
P
G
E
I
V
---------------------------------
T
-------
M
A
I
P
A
E
I
D
P
V
I
V
E
K
M
R
D
Y
A
A
T
A
F
R
T
L
G
C
C
G
L
S
R
C
D
F
F
L
T
E
D
G
K
V
Y
L
N
E
L
N
T
M
P
G
F
T
--
S
M
Y
P
L
L
W
E
N
M
G
L
S
Y
S
V
L
I
E
E
L
V
S
L
A
K
E
M
F
D
K
R
E
S
------
55
PsiBlast_CBE
70.87
32%
-94
- C1 -
3SE7
3
?
D:
[6-340]
-----
I
G
I
I
F
G
G
V
S
E
E
H
D
I
S
V
K
S
A
R
E
V
A
T
H
L
G
T
---
G
-
V
F
-
E
P
F
Y
L
G
I
T
K
S
G
----------
A
W
Q
L
C
DGPGENW
E
D
G
N
--
C
R
------
P
A
------
V
L
S
----------
P
D
----
R
SVH
G
L
----
L
------
V
--------
L
--
E
-
Q
--
G
K
Y
E
T
I
R
------------------------------------
L
---
D
L
V
L
P
V
L
H
G
K
L
G
E
D
G
A
I
Q
G
L
L
E
L
S
G
I
P
Y
V
G
C
D
I
Q
S
S
A
L
C
M
D
K
S
L
T
Y
L
V
A
R
S
-
A
-
G
I
A
T
P
N
F
W
T
V
T
A
D
E
---------
K
I
P
T
D
Q
L
T
Y
P
V
F
V
K
P
A
R
S
G
S
S
F
G
V
S
K
V
A
R
E
E
D
L
Q
G
A
V
E
A
A
R
E
Y
D
S
K
V
L
I
E
E
A
V
-
I
-
G
-
T
E
I
G
C
A
V
M
G
N
G
--
P
------
E
L
I
-
T
G
E
V
D
-----
Q
I
-----
T
L
S
-------------------GSDNSA-
V
T
V
P
A
D
I
S
T
T
S
R
S
L
V
Q
D
T
A
K
A
V
Y
R
A
L
G
C
R
G
L
S
R
V
D
L
F
L
T
E
D
G
K
V
V
L
N
E
V
N
T
F
P
G
M
T
S
Y
S
R
Y
P
R
M
M
T
A
A
G
L
S
R
A
D
V
I
D
R
L
V
S
L
A
---------------
53
PsiBlast_CBE
70.82
32%
-93
- C1 -
3SE7
3
?
F:
[6-340]
-----
I
G
I
I
F
G
G
V
S
E
E
H
D
I
S
V
K
S
A
R
E
V
A
T
H
L
G
T
---
G
-
V
F
-
E
P
F
Y
L
G
I
T
K
S
G
----------
A
W
Q
LCDGPGENW
E
D
G
N
--
C
R
------
P
A
------
V
L
S
----------
P
D
----
R
SVHGL----
L
------
V
--------
L
--
E
-
Q
--
G
K
Y
E
T
I
R
------------------------------------
L
---
D
L
V
L
P
V
L
H
G
K
L
G
E
D
G
A
I
Q
G
L
L
E
L
S
G
I
P
Y
V
G
C
D
I
Q
S
S
A
L
C
M
D
K
S
L
T
Y
L
V
A
R
S
-
A
-
G
I
A
T
P
N
F
W
T
V
T
A
D
E
---------
K
I
P
T
D
Q
L
T
Y
P
V
F
V
K
P
A
R
S
G
S
S
F
G
V
S
K
V
A
R
E
E
D
L
Q
G
A
V
E
A
A
R
E
Y
D
S
K
V
L
I
E
E
A
V
-
I
-
G
-
T
E
I
G
C
A
V
M
G
N
G
--
P
------
E
L
I
-
T
G
E
V
D
-----
Q
I
-----
T
L
S
-------------------GSDNSA-
V
T
V
P
A
D
I
S
T
T
S
R
S
L
V
Q
D
T
A
K
A
V
Y
R
A
L
G
C
R
G
L
S
R
V
D
L
F
L
T
E
D
G
K
V
V
L
N
E
V
N
T
F
P
G
M
T
S
Y
S
R
Y
P
R
M
M
T
A
A
G
L
S
R
A
D
V
I
D
R
L
V
S
L
A
---------------
10
PsiBlast_PDB
70.60
38%
-82
- C1 -
3E5N
-
?
A:
[2-360]
-
R
K
I
R
V
G
L
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
D
A
L
D
P
---
Q
-
R
F
-
E
P
V
L
I
G
I
D
K
Q
G
----------
Q
W
H
---------
V
N
D
P
--
D
S
------
F
L
------
L
H
A
----------
D
D
PA
R
I
A
---------
L
------
H
RSGR
G
V
A
L
L
--
P
-
G
--
A
Q
Q
Q
Q
L
R
P
I
-------
Q
--------
Q
A
L
A
Q
-------------
I
---
D
V
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
R
D
-
A
-
R
L
A
V
A
P
F
V
C
F
D
R
---
H
T
A
A
H
A
D
V
D
T
L
I
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
-
A
-
G
-
R
E
I
E
C
A
V
L
G
N
A
-
V
P
------
H
A
S
V
C
G
E
V
V
-----
V
---------------------------
E
-------
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
L
L
-----
26
PsiBlast_CBE
70.51
43%
-86
- C1 -
3I12
1
DDLA_SALTY
B:
[1-354]
M
A
K
L
R
V
G
I
V
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
K
N
I
V
D
A
I
D
K
---
T
-
R
F
-
D
V
V
L
L
G
I
D
K
A
G
----------
Q
W
H
---------
V
N
D
A
--
E
N
------
Y
L
------
Q
N
A
----------
D
D
----
P
---------
A
------
H
--------
I
--
A
L
R
--
P
S
A
I
S
L
A
Q
V
P
GKHQHQ
L
I
---
N
---
A
Q
N
G
Q
P
------------
L
PTV
D
V
I
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
M
L
R
V
A
N
L
P
F
V
G
S
D
V
L
S
S
A
A
C
M
D
K
D
V
A
K
R
L
L
R
D
-
A
-
G
L
N
I
A
P
F
I
T
L
T
R
T
N
R
H
A
F
S
---
F
A
E
V
E
S
R
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
K
V
A
N
E
A
Q
Y
Q
Q
A
V
A
L
A
F
E
F
D
H
K
V
V
V
E
Q
G
I
-
K
-
G
-
R
E
I
E
C
A
V
L
G
N
D
-
N
P
------
Q
A
S
T
C
G
E
I
V
-----
L
---------------------------
Q
-------
V
V
V
P
A
Q
I
P
S
E
V
N
D
K
I
R
A
I
A
I
Q
A
Y
Q
T
L
G
C
A
G
M
A
R
V
D
V
F
L
T
A
D
N
E
V
V
I
N
E
I
N
T
L
P
G
F
T
N
I
S
M
Y
P
K
L
W
Q
A
S
G
L
G
Y
T
D
L
I
S
R
L
I
E
L
A
L
E
R
H
-----------
25
PsiBlast_CBE
70.47
43%
-85
- C1 -
3I12
1
DDLA_SALTY
C:
[2-354]
-
A
K
L
R
V
G
I
V
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
K
N
I
V
D
A
I
D
K
---
T
-
R
F
-
D
V
V
L
L
G
I
D
K
A
G
----------
Q
W
H
---------
V
N
D
A
--
E
N
------
Y
L
------
Q
N
A
----------
D
D
----
P
---------
A
------
H
--------
I
--
A
L
R
--
P
S
A
I
S
L
A
Q
V
P
GKHQHQ
L
I
---
N
---
A
Q
N
G
Q
P
------------
L
PTV
D
V
I
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
M
L
R
V
A
N
L
P
F
V
G
S
D
V
L
S
S
A
A
C
M
D
K
D
V
A
K
R
L
L
R
D
-
A
-
G
L
N
I
A
P
F
I
T
L
T
R
T
N
R
H
A
F
S
---
F
A
E
V
E
S
R
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
K
V
A
N
E
A
Q
Y
Q
Q
A
V
A
L
A
F
E
F
D
H
K
V
V
V
E
Q
G
I
-
K
-
G
-
R
E
I
E
C
A
V
L
G
N
D
-
N
P
------
Q
A
S
T
C
G
E
I
V
-----
L
----------------------
G
--
A
-
Q
-------
V
V
V
P
A
Q
I
P
S
E
V
N
D
K
I
R
A
I
A
I
Q
A
Y
Q
T
L
G
C
A
G
M
A
R
V
D
V
F
L
T
A
D
N
E
V
V
I
N
E
I
N
T
L
P
G
F
T
N
I
S
M
Y
P
K
L
W
Q
A
S
G
L
G
Y
T
D
L
I
S
R
L
I
E
L
A
L
E
R
H
-----------
58
PsiBlast_CBE
70.38
32%
-97
- C1 -
3SE7
3
?
A:
[6-340]
-----
I
G
I
I
F
G
G
V
S
E
E
H
D
I
S
V
K
S
A
R
E
V
A
T
H
L
G
T
---
G
-
V
F
-
E
P
F
Y
L
G
I
T
K
S
G
----------
A
W
Q
L
C
DGPGENW
E
D
G
N
--
C
R
------
P
A
------
V
L
S
----------
P
D
----
R
SVH
G
L
----
L
------
V
--------
L
--
E
-
Q
--
G
K
Y
E
T
I
R
------------------------------------
L
---
D
L
V
L
P
V
L
H
G
K
L
G
E
D
G
A
I
Q
G
L
L
E
L
S
G
I
P
Y
V
G
C
D
I
Q
S
S
A
L
C
M
D
K
S
L
T
Y
L
V
A
R
S
-
A
-
G
I
A
T
P
N
F
W
T
V
T
A
D
E
---------
K
I
P
T
D
Q
L
T
Y
P
V
F
V
K
P
A
R
S
G
S
S
F
G
V
S
K
V
A
R
E
E
D
L
Q
G
A
V
E
A
A
R
E
Y
D
S
K
V
L
I
E
E
A
V
-
I
-
G
-
T
E
I
G
C
A
V
M
G
N
G
--
P
------
E
L
I
-
T
G
E
V
D
-----
Q
I
-----
T
L
S
-------------------GSDNSA-
V
T
V
P
A
D
I
S
T
T
S
R
S
L
V
Q
D
T
A
K
A
V
Y
R
A
L
G
C
R
G
L
S
R
V
D
L
F
L
T
E
D
G
K
V
V
L
N
E
V
N
T
F
P
G
M
T
S
Y
S
R
Y
P
R
M
M
T
A
A
G
L
S
R
A
D
V
I
D
R
L
V
S
L
A
---------------
72
HHSearch
69.82
44%
-79
- C1 -
3I12
1
DDLA_SALTY
A:
[2-362]
-
A
K
L
R
V
G
I
V
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
K
N
I
V
D
A
I
D
K
---
T
-
R
F
-
D
V
V
L
L
G
I
D
K
A
G
----------
Q
W
H
---------
V
N
D
A
--
E
N
-------
Y
------
L
Q
N
ADDPA
H
I
A
L
R
P
S
----
A
---------
I
------
S
--------
L
A
Q
V
-
P
--
G
K
H
Q
---
H
Q
-------
L
I
---
N
AQN
G
Q
P
L
P
T
------------
V
---
D
V
I
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
M
L
R
V
A
N
L
P
F
V
G
S
D
V
L
S
S
A
A
C
M
D
K
D
V
A
K
R
L
L
R
D
-
A
-
G
L
N
I
A
P
F
I
T
L
T
R
T
N
R
H
A
---
F
S
F
A
E
V
E
S
R
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
K
V
A
N
E
A
Q
Y
Q
Q
A
V
A
L
A
F
E
F
D
H
K
V
V
V
E
Q
G
I
-
K
-
G
-
R
E
I
E
C
A
V
L
G
N
D
-
N
P
------
Q
A
S
T
C
G
E
I
V
-----
L
N
-----
S
E
F
Y
--
D
T
K
Y
I
D
--
D
-
N
--
G
A
Q
-------
V
V
V
P
A
Q
I
P
S
E
V
N
D
K
I
R
A
I
A
I
Q
A
Y
Q
T
L
G
C
A
G
M
A
R
V
D
V
F
L
T
A
D
N
E
V
V
I
N
E
I
N
T
L
P
G
F
T
N
I
S
M
Y
P
K
L
W
Q
A
S
G
L
G
Y
T
D
L
I
S
R
L
I
E
L
A
L
E
R
H
T
A
N
N
A
L
K
T
---
8
PsiBlast_PDB
69.77
38%
-79
- C1 -
3R5F
2
?
A:
[20-382]
--
K
I
R
V
G
L
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
D
A
L
D
P
---
Q
-
R
F
-
E
P
V
L
I
G
I
D
K
Q
G
----------
Q
W
H
---------
V
N
D
P
--
D
S
------
F
L
------
L
H
A
----------
D
D
PA
R
I
A
---------
L
------
H
RSGR
G
V
A
L
L
--
P
-
G
--
A
Q
Q
Q
Q
L
R
P
I
-------
Q
---------
A
L
A
Q
-------------
I
---
D
V
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
R
D
-
A
-
R
L
A
V
A
P
F
V
C
F
D
R
---
H
T
A
A
H
A
D
V
D
T
L
I
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
-
A
-
G
-
R
E
I
E
C
A
V
L
G
N
A
-
V
P
------
H
A
S
V
C
G
E
V
V
-----
V
---------------------------
E
-------
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
L
L
R
S
A
V
E
54
PsiBlast_CBE
69.53
32%
-95
- C1 -
3SE7
3
?
E:
[6-340]
-----
I
G
I
I
F
G
G
V
S
E
E
H
D
I
S
V
K
S
A
R
E
V
A
T
H
L
G
T
---
G
-
V
F
-
E
P
F
Y
L
G
I
T
K
S
G
----------
A
W
Q
LCDGPGENW
E
D
G
N
--
C
R
------
P
A
------
V
L
S
----------
P
D
----
R
SVHGL----
L
------
V
--------
L
--
E
-
Q
--
G
K
Y
E
T
I
R
------------------------------------
L
---
D
L
V
L
P
V
L
H
G
K
L
G
E
D
G
A
I
Q
G
L
L
E
L
S
G
I
P
Y
V
G
C
D
I
Q
S
S
A
L
C
M
D
K
S
L
T
Y
L
V
A
R
S
-
A
-
G
I
A
T
P
N
F
W
T
V
T
A
D
E
---------
K
I
P
T
D
Q
L
T
Y
P
V
F
V
K
P
A
R
S
G
S
S
F
G
V
S
K
V
A
R
E
E
D
L
Q
G
A
V
E
A
A
R
E
Y
D
S
K
V
L
I
E
E
A
V
-
I
-
G
-
T
E
I
G
C
A
V
M
G
N
G
--
P
------
E
L
I
-
T
G
E
V
D
-----
Q
I
-----
T
L
S
H
G
F
----------------SGSDNSA
V
T
V
P
A
D
I
S
T
T
S
R
S
L
V
Q
D
T
A
K
A
V
Y
R
A
L
G
C
R
G
L
S
R
V
D
L
F
L
T
E
D
G
K
V
V
L
N
E
V
N
T
F
P
G
M
T
S
Y
S
R
Y
P
R
M
M
T
A
A
G
L
S
R
A
D
V
I
D
R
L
V
S
L
A
---------------
11
PsiBlast_PDB
69.51
38%
-81
- C1 -
4ME6
2
?
A:
[21-384]
-
R
K
I
R
V
G
L
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
D
A
L
D
P
---
Q
-
R
F
-
E
P
V
L
I
G
I
D
K
Q
G
----------
Q
W
H
---------
V
N
D
P
--
D
S
------
F
L
------
L
H
A
----------
D
D
PA
R
I
A
---------
L
------
H
RSGR
G
V
A
L
L
--
P
-
G
--
A
Q
Q
Q
Q
L
R
P
I
-------
Q
-----------
A
Q
-------------
I
---
D
V
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
R
D
-
A
-
R
L
A
V
A
P
F
V
C
F
D
R
---
H
T
-
A
H
A
D
V
D
T
L
I
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
---
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
-
A
-
G
-
R
E
I
E
C
A
V
L
G
N
A
-
V
P
------
H
A
S
V
C
G
E
V
V
---------------------------------
E
-------
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
L
L
R
S
A
V
E
46
PsiBlast_CBE
69.50
32%
-84
- C1 -
4C5B
7
DDLB_ECOLI
B:
[27-329]
---
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
GGI
D
-
A
Y
-
P
V
D
--------------------
P
---------
K
E
V
D
--
V
T
-------
Q
------
L
K
S
----------
M
G
---------------------------------------------------------------------------------
F
---
Q
K
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
-
A
-
G
L
P
V
A
P
W
V
A
L
T
R
A
E
F
E
K
G
L
S
D
K
Q
L
A
E
I
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
-
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
-
I
L
------
P
S
I
---
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
S
--
D
-
E
--
T
-
Q
-------
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
---------------
9
PsiBlast_PDB
69.28
38%
-81
- C1 -
4L1K
2
?
A:
[19-377]
-
R
K
I
R
V
G
L
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
D
A
L
D
P
---
Q
-
R
F
-
E
P
V
L
I
G
I
D
K
Q
G
----------
Q
W
H
---------
V
N
D
P
--
D
S
------
F
L
------
L
H
A
----------
D
D
PA
R
I
A
---------
L
------
H
RSGR
G
V
A
L
L
--
P
-
G
--
A
Q
Q
Q
Q
L
R
P
I
-------
Q
--------
Q
A
L
A
Q
-------------
I
---
D
V
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
R
D
-
A
-
R
L
A
V
A
P
F
V
C
F
D
R
---
H
T
A
A
H
A
D
V
D
T
L
I
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
-
A
-
G
-
R
E
I
E
C
A
V
L
G
N
A
-
V
P
------
H
A
S
V
C
G
E
V
V
-----
V
---------------------------
E
-------
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
L
L
-----
7
PsiBlast_PDB
69.28
38%
-79
- C1 -
3RFC
2
?
A:
[19-381]
-
R
K
I
R
V
G
L
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
D
A
L
D
P
---
Q
-
R
F
-
E
P
V
L
I
G
I
D
K
Q
G
----------
Q
W
H
---------
V
N
D
P
--
D
S
------
F
L
------
L
H
A
----------
D
D
PA
R
I
A
---------
L
------
H
RSGR
G
V
A
L
L
--
P
-
G
--
A
Q
Q
Q
Q
L
R
P
I
-------
Q
--------
Q
A
L
A
Q
-------------
I
---
D
V
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
R
D
-
A
-
R
L
A
V
A
P
F
V
C
F
D
R
---
H
T
A
A
H
A
D
V
D
T
L
I
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
-
A
-
G
-
R
E
I
E
C
A
V
L
G
N
A
-
V
P
------
H
A
S
V
C
G
E
V
V
-----
V
---------------------------
E
-------
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
L
L
R
S
A
V
-
52
PsiBlast_CBE
69.17
32%
-92
- C1 -
1E4E
12
VANA_ENTFC
B:
[2-340]
-
N
R
I
K
V
A
I
L
F
G
G
C
S
E
E
H
D
V
S
V
K
S
A
I
E
I
A
A
N
I
N
K
---
E
-
K
Y
-
E
P
L
Y
I
G
I
T
K
S
G
VWKMCEKPCA
E
W
E
---------
N
E
N
C
--
Y
S
------
A
V
------
L
S
P
----------
D
K
----
K
---------
M
------
H
GLL-----
V
--
K
-
K
--
N
H
E
Y
E
I
N
H
V
--------------------------------------
D
V
A
F
S
A
L
H
G
K
S
G
E
D
G
S
I
Q
G
L
F
E
L
S
G
I
P
F
V
G
C
D
I
Q
S
S
A
I
C
M
D
K
S
L
T
Y
I
V
A
K
N
-
A
-
G
I
A
T
P
A
F
W
V
I
N
K
D
D
---------
R
P
V
A
A
T
F
T
Y
P
V
F
V
K
P
A
R
S
G
S
S
F
G
V
K
K
V
N
S
A
D
E
L
D
Y
A
I
E
S
A
R
Q
Y
D
S
K
I
L
I
E
Q
A
V
-
S
-
G
-
C
E
V
G
C
A
V
L
G
N
S
---------
A
A
L
V
V
G
E
V
D
-----
Q
I
-----
R
L
Q
Y
G
I
F
R
I
H
Q
E
--
V
-
E
--
P
-
E
KGSENAV
I
T
V
P
A
D
L
S
A
E
E
R
G
R
I
Q
E
T
V
K
K
I
Y
K
T
L
G
C
R
G
L
A
R
V
D
M
F
L
Q
D
R
G
R
I
V
L
N
E
V
N
T
L
P
G
F
T
S
Y
S
R
Y
P
R
M
M
A
A
A
G
I
S
L
P
E
L
I
D
R
L
I
V
L
A
---------------
45
PsiBlast_CBE
68.93
32%
-83
- C1 -
4C5C
8
DDLB_ECOLI
A:
[27-329]
---
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
G
GI
D
-
A
Y
-
P
V
D
--------------------
P
---------
K
E
V
D
--
V
T
-------
Q
------
L
K
S
----------
M
G
---------------------------------------------------------------------------------
F
---
Q
K
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
-
A
-
G
L
P
V
A
P
W
V
A
L
T
R
A
E
F
E
K
G
L
S
D
K
Q
L
A
E
I
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
-
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
-
I
L
------
P
S
I
---
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
S
--
D
-
E
--
T
-
Q
-------
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
---------------
49
PsiBlast_CBE
67.91
32%
-83
- C1 -
4C5A
7
DDLB_ECOLI
A:
[27-329]
---
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
G
GI
D
-
A
Y
-
P
V
D
--------------------
P
---------
K
E
V
D
--
V
T
-------
Q
------
L
K
S
----------
M
G
---------------------------------------------------------------------------------
F
---
Q
K
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
-
A
-
G
L
P
V
A
P
W
V
A
L
T
R
A
E
F
E
K
G
L
S
D
K
Q
L
A
E
I
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
-
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
-
I
L
------
P
S
I
---
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
S
--
D
-
E
--
T
-
Q
-------
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
---------------
20
PsiBlast_PDB
67.81
35%
-82
- C1 -
1EHI
4
DDL_LEUMM
A:
[3-362]
--
K
K
R
V
A
L
I
F
G
G
N
S
S
E
H
D
V
S
K
R
S
A
Q
N
F
Y
N
A
I
E
A
---
T
G
K
Y
-
E
I
I
V
F
A
I
A
--------------------------
Q
N
G
--
F
F
------
L
D
------
T
E
S
----------
S
K
----
K
---------
I
------
L
--------
A
--
L
-
E
--
D
E
Q
P
I
V
D
A
F
-------
M
K
---
T
---
V
D
A
S
D
P
LARIHALKSAGD
F
---
D
I
F
F
P
V
V
H
G
N
L
G
E
D
G
T
L
Q
G
L
F
K
L
L
D
K
P
Y
V
G
A
P
L
R
G
H
A
V
S
F
D
K
A
L
T
K
E
L
L
T
V
-
N
-
G
I
R
N
T
K
Y
I
V
V
D
P
E
S
A
N
N
W
S
W
D
--
K
I
V
A
E
-
L
G
N
I
V
F
V
K
A
A
N
Q
G
S
S
V
G
I
S
R
V
T
N
A
E
E
Y
T
E
A
L
S
D
S
F
Q
Y
D
Y
K
V
L
I
E
E
A
V
-
N
G
A
-
R
E
L
E
V
G
V
I
G
N
D
-
Q
P
L
V
S
E
I
G
A
H
T
V
P
N
Q
G
S
-----
G
D
------
G
W
Y
D
Y
N
N
K
F
V
D
--
N
-
S
A-
V
-
H
-------
F
Q
I
P
A
Q
L
S
P
E
V
T
K
E
V
K
Q
M
A
L
D
A
Y
K
V
L
N
L
R
G
E
A
R
M
D
F
L
L
D
E
N
N
V
P
Y
L
G
E
P
N
T
L
P
G
F
T
N
M
S
L
F
K
R
L
W
D
Y
S
D
I
N
N
A
K
L
V
D
M
L
I
D
Y
G
F
E
D
F
A
Q
N
K
K
L
S
----
44
PsiBlast_CBE
67.36
32%
-81
- C1 -
4C5C
7
DDLB_ECOLI
B:
[27-329]
---
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
GGI
D
-
A
Y
-
P
V
D
--------------------
P
---------
K
E
V
D
--
V
T
-------
Q
------
L
K
S
----------
M
G
---------------------------------------------------------------------------------
F
---
Q
K
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
-
A
-
G
L
P
V
A
P
W
V
A
L
T
R
A
E
F
E
K
G
L
S
D
K
Q
L
A
E
I
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
-
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
-
I
L
------
P
S
I
---
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
S
--
D
-
E
--
T
-
Q
-------
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
---------------
47
PsiBlast_CBE
67.31
32%
-81
- C1 -
4C5B
9
DDLB_ECOLI
A:
[27-329]
---
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
G
GI
D
-
A
Y
-
P
V
D
--------------------
P
---------
K
E
V
D
--
V
T
-------
Q
------
L
K
S
----------
M
G
---------------------------------------------------------------------------------
F
---
Q
K
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
-
A
-
G
L
P
V
A
P
W
V
A
L
T
R
A
E
F
E
K
G
L
S
D
K
Q
L
A
E
I
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
-
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
-
I
L
------
P
S
I
---
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
S
--
D
-
E
--
T
-
Q
-------
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
---------------
48
PsiBlast_CBE
67.16
32%
-84
- C1 -
4C5A
4
DDLB_ECOLI
B:
[27-329]
---
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
G
GI
D
-
A
Y
-
P
V
D
--------------------
P
---------
K
E
V
D
--
V
T
-------
Q
------
L
K
S
----------
M
G
---------------------------------------------------------------------------------
F
---
Q
K
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
-
A
-
G
L
P
V
A
P
W
V
A
L
T
R
A
E
F
E
K
G
L
S
D
K
Q
L
A
E
I
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
-
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
-
I
L
------
P
S
I
---
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
S
--
D
-
E
--
T
-
Q
-------
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
---------------
50
PsiBlast_CBE
66.88
32%
-85
- C1 -
1IOW
4
DDLB_ECOLI
A:
[3-305]
---
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
G
GI
D
-
A
Y
-
P
V
D
--------------------
P
---------
K
E
V
D
--
V
T
-------
Q
------
L
K
S
----------
M
G
---------------------------------------------------------------------------------
F
---
Q
K
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
-
A
-
G
L
P
V
A
P
W
V
A
L
T
R
A
E
F
E
K
G
L
S
D
K
Q
L
A
E
I
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
-
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
-
I
L
------
P
S
I
---
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
F
L
S
--
D
-
E
--
T
-
Q
-------
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
---------------
51
PsiBlast_CBE
66.71
32%
-88
- C1 -
1E4E
13
VANA_ENTFC
A:
[2-340]
-
N
R
I
K
V
A
I
L
F
G
G
C
S
E
E
H
D
V
S
V
K
S
A
I
E
I
A
A
N
I
N
K
---
E
-
K
Y
-
E
P
L
Y
I
G
I
T
K
S
G
V
W
K
M
C
EKPCA
E
W
E
---------
N
E
N
C
--
Y
S
------
A
V
------
L
S
P
----------
D
K
----
K
---------
M
------
H
G
L
L
-----
V
--
K
-
K
--
N
H
E
Y
E
I
N
H
V
--------------------------------------
D
V
A
F
S
A
L
H
G
K
S
G
E
D
G
S
I
Q
G
L
F
E
L
S
G
I
P
F
V
G
C
D
I
Q
S
S
A
I
C
M
D
K
S
L
T
Y
I
V
A
K
N
-
A
-
G
I
A
T
P
A
F
W
V
I
N
K
D
D
---------
R
P
V
A
A
T
F
T
Y
P
V
F
V
K
P
A
R
S
G
S
S
F
G
V
K
K
V
N
S
A
D
E
L
D
Y
A
I
E
S
A
R
Q
Y
D
S
K
I
L
I
E
Q
A
V
-
S
-
G
-
C
E
V
G
C
A
V
L
G
N
S
---------
A
A
L
V
V
G
E
V
D
-----
Q
I
-----
R
L
Q
Y
G
I
F
R
I
H
Q
E
--
V
-
E
--
P
-
E
KGSEN
A
V
I
T
V
P
A
D
L
S
A
E
E
R
G
R
I
Q
E
T
V
K
K
I
Y
K
T
L
G
C
R
G
L
A
R
V
D
M
F
L
Q
D
N
G
R
I
V
L
N
E
V
N
T
L
P
G
F
T
S
Y
S
R
Y
P
R
M
M
A
A
A
G
I
S
L
P
E
L
I
D
R
L
I
V
L
A
---------------
70
HHSearch
66.02
35%
-77
- C1 -
1EHI
4
DDL_LEUMM
A:
[3-362]
--
K
K
R
V
A
L
I
F
G
G
N
S
S
E
H
D
V
S
K
R
S
A
Q
N
F
Y
N
A
I
E
A
---
T
-
G
K
Y
E
I
I
V
F
A
I
A
Q
N
G
----------
F
F
L
---------
D
T
E
S
--
S
K
------
K
I
L
A
----
L
E
D
----------
E
Q
----
P
---------
I
V
D
A
F
M
K
T
--------
V
--
D
-
A
--
S
D
P
L
---
A
R
-------
I
H
---
A
---
L
K
S
A
G
D
------------
F
---
D
I
F
F
P
V
V
H
G
N
L
G
E
D
G
T
L
Q
G
L
F
K
L
L
D
K
P
Y
V
G
A
P
L
R
G
H
A
V
S
F
D
K
A
L
T
K
E
L
L
T
V
-
N
-
G
I
R
N
T
K
Y
I
V
V
D
P
E
S
A
N
N
W
---
S
W
D
K
I
V
A
E
L
G
N
I
V
F
V
K
A
A
N
Q
G
S
S
V
G
I
S
R
V
T
N
A
E
E
Y
T
E
A
L
S
D
S
F
Q
Y
D
Y
K
V
L
I
E
E
A
V
-
N
-
G
A
R
E
L
E
V
G
V
I
G
N
D
-
Q
P
------
L
V
S
E
I
G
A
H
T
-----
V
P
NQGSG
D
G
W
Y
D
Y
N
N
K
F
V
D
--
N
-
S
--
A
V
H
-------
F
Q
I
P
A
Q
L
S
P
E
V
T
K
E
V
K
Q
M
A
L
D
A
Y
K
V
L
N
L
R
G
E
A
R
M
D
F
L
L
D
E
N
N
V
P
Y
L
G
E
P
N
T
L
P
G
F
T
N
M
S
L
F
K
R
L
W
D
Y
S
D
I
N
N
A
K
L
V
D
M
L
I
D
Y
G
F
E
D
F
A
Q
N
K
K
L
S
----
42
PsiBlast_CBE
65.56
32%
-82
- C1 -
2DLN
4
DDLB_ECOLI
A:
[3-305]
---
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
G
GI
D
-
A
Y
-
P
V
D
--------------------
P
---------
K
E
V
D
--
V
T
-------
Q
------
L
K
S
----------
M
G
---------------------------------------------------------------------------------
F
---
Q
K
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
-
A
-
G
L
P
V
A
P
W
V
A
L
T
R
A
E
F
E
K
G
L
S
D
K
Q
L
A
E
I
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
-
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
-
I
L
------
P
S
I
---
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
S
--
D
-
E
--
T
-
Q
-------
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
---------------
59
Fugue
65.50
35%
-75
- C1 -
1EHI
4
DDL_LEUMM
A:
[3-362]
--
K
K
R
V
A
L
I
F
G
G
N
S
S
E
H
D
V
S
K
R
S
A
Q
N
F
Y
N
A
I
E
A
T
--
G
-
K
Y
-
E
I
I
V
F
A
I
A
Q
N
G
----------
F
F
L
---------
D
T
E
S
--
S
K
------
K
I
------
L
A
L
----------
E
D
----
E
---------
Q
------
P
--------
I
--
V
-
D
--
A
F
M
K
T
V
D
A
S
DPLAR--
I
H
---
A
---
L
K
S
A
G
D
------------
F
---
D
I
F
F
P
V
V
H
G
N
L
G
E
D
G
T
L
Q
G
L
F
K
L
L
D
K
P
Y
V
G
A
P
L
R
G
H
A
V
S
F
D
K
A
L
T
K
E
L
L
T
V
-
N
-
G
I
R
N
T
K
Y
I
V
V
D
P
E
S
A
N
N
W
S
---
W
D
K
I
V
A
E
L
G
N
I
V
F
V
K
A
A
N
Q
G
S
S
V
G
I
S
R
V
T
N
A
E
E
Y
T
E
A
L
S
D
S
F
Q
Y
D
Y
K
V
L
I
E
E
A
V
N
G
-
A
-
R
E
L
E
V
G
V
I
G
N
D
-
Q
P
------
L
V
S
E
I
G
A
H
T
V
P
NQG
S
G
-----
D
G
W
Y
D
Y
N
N
K
F
V
D
--
N
S
A
--
V
-
H
-------
F
Q
I
P
A
Q
L
S
P
E
V
T
K
E
V
K
Q
M
A
L
D
A
Y
K
V
L
N
L
R
G
E
A
R
M
D
F
L
L
D
E
N
N
V
P
Y
L
G
E
P
N
T
L
P
G
F
T
N
M
S
L
F
K
R
L
W
D
Y
S
D
I
N
N
A
K
L
V
D
M
L
I
D
Y
G
F
E
D
F
A
Q
N
K
K
L
S
----
60
Fugue
64.90
35%
-74
- C1 -
1EHI
4
DDL_LEUMM
A:
[3-362]
--
K
K
R
V
A
L
I
F
G
G
N
S
S
E
H
D
V
S
K
R
S
A
Q
N
F
Y
N
A
I
E
A
---
T
G
K
Y
-
E
I
I
V
F
A
I
A
Q
N
G
----------
F
F
L
---------
D
T
E
S
--
S
K
------
K
I
------
L
A
L
----------
E
D
----
E
---------
Q
------
P
--------
I
--
V
-
D
--
A
F
M
K
T
V
D
A
S
DPLAR--
I
H
---
A
---
L
K
S
A
G
D
------------
F
---
D
I
F
F
P
V
V
H
G
N
L
G
E
D
G
T
L
Q
G
L
F
K
L
L
D
K
P
Y
V
G
A
P
L
R
G
H
A
V
S
F
D
K
A
L
T
K
E
L
L
T
V
-
N
-
G
I
R
N
T
K
Y
I
V
V
D
P
E
S
A
N
N
W
S
---
W
D
K
I
V
A
E
L
G
N
I
V
F
V
K
A
A
N
Q
G
S
S
V
G
I
S
R
V
T
N
A
E
E
Y
T
E
A
L
S
D
S
F
Q
Y
D
Y
K
V
L
I
E
E
A
V
N
G
-
A
-
R
E
L
E
V
G
V
I
G
N
D
-
Q
P
------
L
V
S
E
I
G
A
H
T
V
P
NQG
S
G
-----
D
G
W
Y
D
Y
N
N
K
F
V
D
--
N
S
A
--
V
-
H
-------
F
Q
I
P
A
Q
L
S
P
E
V
T
K
E
V
K
Q
M
A
L
D
A
Y
K
V
L
N
L
R
G
E
A
R
M
D
F
L
L
D
E
N
N
V
P
Y
L
G
E
P
N
T
L
P
G
F
T
N
M
S
L
F
K
R
L
W
D
Y
S
D
I
N
N
A
K
L
V
D
M
L
I
D
Y
G
F
E
D
F
A
Q
N
K
K
L
S
----
74
HHSearch
64.39
34%
-75
- C1 -
1E4E
13
VANA_ENTFC
A:
[2-342]
-
N
R
I
K
V
A
I
L
F
G
G
C
S
E
E
H
D
V
S
V
K
S
A
I
E
I
A
A
N
I
N
K
---
E
-
K
Y
-
E
P
L
Y
I
G
I
T
K
S
G
----------
V
W
K
---------
M
C
E
K
--
P
C
------
A
E
WENENC
Y
S
A
----------
V
---------------
L
------
S
--------
P
--
D
-
K
KM
H
G
L
L
---
V
K
-------
K
N
---
H
---
E
Y
E
I
N
H
------------
V
---
D
V
A
F
S
A
L
H
G
K
S
G
E
D
G
S
I
Q
G
L
F
E
L
S
G
I
P
F
V
G
C
D
I
Q
S
S
A
I
C
M
D
K
S
L
T
Y
I
V
A
K
N
-
A
-
G
I
A
T
P
A
F
W
V
I
N
K
D
D
R
P
---------
V
A
A
T
F
T
Y
P
V
F
V
K
P
A
R
S
G
S
S
F
G
V
K
K
V
N
S
A
D
E
L
D
Y
A
I
E
S
A
R
Q
Y
D
S
K
I
L
I
E
Q
A
V
-
S
-
G
-
C
E
V
G
C
A
V
L
G
N
S
A
A
L
------
V
V
G
E
V
D
Q
I
R
-----
L
Q
-----
Y
G
I
F
R
I
H
Q
E
V
E
P
EK
G
-
S
EN
A
-
V
-------
I
T
V
P
A
D
L
S
A
E
E
R
G
R
I
Q
E
T
V
K
K
I
Y
K
T
L
G
C
R
G
L
A
R
V
D
M
F
L
Q
D
N
G
R
I
V
L
N
E
V
N
T
L
P
G
F
T
S
Y
S
R
Y
P
R
M
M
A
A
A
G
I
S
L
P
E
L
I
D
R
L
I
V
L
A
L
K
-------------
16
PsiBlast_PDB
63.69
40%
-82
- C1 -
2ZDQ
3
DDL_THET8
A:
[2-317]
----
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-------
P
F
-
P
T
D
L
A
V
I
A
Q
D
G
----------
R
W
L
L
--------
G
E
K
A
--
L
T
------
A
----------------------------------------------------
L
--
E
-
A
--
K
A
A
P
E
G
E
H
P
-------
F
P
---
P
---
P
L
S
W
E
R
------------
Y
---
D
V
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
-
A
-
G
V
P
V
V
P
W
V
A
V
R
K
G
E
P
P
V
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
-
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
P
--
G
-
R
--
A
-
E
-------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
---------------
43
PsiBlast_CBE
63.65
32%
-81
- C1 -
1IOV
5
DDLB_ECOLI
A:
[3-305]
---
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
G
GI
D
-
A
Y
-
P
V
D
--------------------
P
---------
K
E
V
D
--
V
T
-------
Q
------
L
K
S
----------
M
G
---------------------------------------------------------------------------------
F
---
Q
K
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
-
A
-
G
L
P
V
A
P
W
V
A
L
T
R
A
E
F
E
K
G
L
S
D
K
Q
L
A
E
I
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
-
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
-
I
L
------
P
S
I
---
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
S
--
D
-
E
--
T
-
Q
-------
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
---------------
15
PsiBlast_PDB
63.08
40%
-78
- C1 -
2ZDH
4
DDL_THET8
A:
[2-317]
----
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-------
P
F
-
P
T
D
L
A
V
I
A
Q
D
G
----------
R
W
L
L
--------
G
E
K
A
--
L
T
------
A
----------------------------------------------------
L
--
E
-
A
--
K
A
A
P
E
G
E
H
P
-------
F
P
---
P
---
P
L
S
W
E
R
------------
Y
---
D
V
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
-
A
-
G
V
P
V
V
P
W
V
A
V
R
K
G
E
P
P
V
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
-
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
P
--
G
-
R
--
A
-
E
-------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
---------------
37
PsiBlast_CBE
62.85
40%
-86
- C1 -
2YZM
1
DDL_THET8
B:
[2-317]
----
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-------
P
F
-
P
T
D
L
A
V
I
A
Q
D
G
----------
R
W
L
L
--------
G
E
K
A
--
L
T
------
A
----------------------------------------------------
L
--
E
-
A
--
K
A
A
P
E
G
E
H
P
-------
F
P
---
P
---
P
L
S
W
E
R
------------
Y
---
D
V
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
-
A
-
G
V
P
V
V
P
W
V
A
V
R
K
G
E
P
P
V
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
-
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
-------
T
P
--
G
-
R
--
A
-
E
-------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
---------------
28
PsiBlast_CBE
62.65
40%
-81
- C1 -
2ZDH
3
DDL_THET8
D:
[2-317]
----
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-------
P
F
-
P
T
D
L
A
V
I
A
Q
D
G
----------
R
W
L
L--------
G
E
K
A
--
L
T
------
A
----------------------------------------------------
L
--
E
-
A
--
K
A
A
P
E
G
E
H
P
-------
F
P
---
P
---
P
L
S
W
E
R
------------
Y
---
D
V
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
-
A
-
G
V
P
V
V
P
W
V
A
V
R
K
G
E
P
P
V
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
-
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
P
--
G
-
R
--
A
-
E
-------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
---------------
29
PsiBlast_CBE
62.60
40%
-83
- C1 -
2ZDH
4
DDL_THET8
C:
[2-317]
----
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-------
P
F
-
P
T
D
L
A
V
I
A
Q
D
G
----------
R
W
L
L
--------
G
E
K
A
--
L
T
------
A
----------------------------------------------------
L
--
E
-
A
--
K
A
A
P
E
G
E
H
P
-------
F
P
---
P
---
P
L
S
W
E
R
------------
Y
---
D
V
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
-
A
-
G
V
P
V
V
P
W
V
A
V
R
K
G
E
P
P
V
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
-
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
---
T
K
Y
T
P
--
G
-
R
--
A
-
E
-------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
---------------
33
PsiBlast_CBE
62.57
40%
-91
- C1 -
2ZDG
1
DDL_THET8
B:
[2-317]
----
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-------
P
F
-
P
T
D
L
A
V
I
A
Q
D
G
----------
R
W
L
L
--------
G
E
K
A
--
L
T
------
A
----------------------------------------------------
L
--
E
-
A
--
K
A
A
P
E
G
E
H
P
-------
F
P
---
P
---
P
L
S
W
E
R
------------
Y
---
D
V
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
-
A
-
G
V
P
V
V
P
W
V
A
V
R
K
G
E
P
P
V
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
-
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
--------------------
E
-------
L
L
I
P
A
P
L
D
--
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
---------------
30
PsiBlast_CBE
62.44
40%
-81
- C1 -
2ZDH
4
DDL_THET8
B:
[2-317]
----
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-------
P
F
-
P
T
D
L
A
V
I
A
Q
D
G
----------
R
W
L
L
--------
G
E
K
A
--
L
T
------
A
----------------------------------------------------
L
--
E
-
A
--
K
A
A
P
E
G
E
H
P
-------
F
P
---
P
---
P
L
S
W
E
R
------------
Y
---
D
V
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
-
A
-
G
V
P
V
V
P
W
V
A
V
R
K
G
E
P
P
V
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
-
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
-------
P
--
G
-
R
--
A
-
E
-------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
---------------
34
PsiBlast_CBE
62.37
40%
-88
- C1 -
2YZN
1
DDL_THET8
C:
[2-317]
----
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-------
P
F
-
P
T
D
L
A
V
I
A
Q
D
G
----------
R
W
L
L
--------
G
E
K
A
--
L
T
------
A
----------------------------------------------------
L
--
E
-
A
--
K
A
A
P
E
G
E
H
P
-------
F
P
---
P
---
P
L
S
W
E
R
------------
Y
---
D
V
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
-
A
-
G
V
P
V
V
P
W
V
A
V
R
K
G
E
P
P
V
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
-
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
----------
P
--
G
-
R
--
A
-
E
-------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
---------------
12
PsiBlast_PDB
61.92
40%
-86
- C1 -
2YZM
1
DDL_THET8
A:
[2-317]
----
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-------
P
F
-
P
T
D
L
A
V
I
A
Q
D
G
----------
R
W
L
L
--------
G
E
K
A
--
L
T
------
A
----------------------------------------------------
L
--
E
-
A
--
K
A
A
P
E
G
E
H
P
-------
F
P
---
P
---
P
L
S
W
E
R
------------
Y
---
D
V
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
-
A
-
G
V
P
V
V
P
W
V
A
V
R
K
G
E
P
P
V
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
-
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
P
--
G
-
R
--
A
-
E
-------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
---------------
27
PsiBlast_CBE
61.75
40%
-80
- C1 -
2ZDQ
3
DDL_THET8
B:
[2-317]
----
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-------
P
F
-
P
T
D
L
A
V
I
A
Q
D
G
----------
R
W
L
L--------
G
E
K
A
--
L
T
------
A
----------------------------------------------------
L
--
E
-
A
--
K
A
A
P
E
G
E
H
P
-------
F
P
---
P
---
P
L
S
W
E
R
------------
Y
---
D
V
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
-
A
-
G
V
P
V
V
P
W
V
A
V
R
K
G
E
P
P
V
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
-
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
P
--
G
-
R
--
A
-
E
-------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
---------------
35
PsiBlast_CBE
61.19
40%
-84
- C1 -
2YZN
1
DDL_THET8
B:
[2-317]
----
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-------
P
F
-
P
T
D
L
A
V
I
A
Q
D
G
----------
R
W
L
L
--------
G
E
K
A
--
L
T
------
A
----------------------------------------------------
L
--
E
-
A
--
K
A
A
P
E
G
E
H
P
-------
F
P
---
P
---
P
L
S
W
E
R
------------
Y
---
D
V
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
-
A
-
G
V
P
V
V
P
W
V
A
V
R
K
G
E
P
P
V
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
-
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
------
T
P
--
G
-
R
--
A
-
E
-------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
---------------
14
PsiBlast_PDB
61.13
40%
-86
- C1 -
2ZDG
1
DDL_THET8
A:
[2-317]
----
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-------
P
F
-
P
T
D
L
A
V
I
A
Q
D
G
----------
R
W
L
L
--------
G
E
K
A
--
L
T
------
A
----------------------------------------------------
L
--
E
-
A
--
K
A
A
P
E
G
E
H
P
-------
F
P
---
P
---
P
L
S
W
E
R
------------
Y
---
D
V
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
-
A
-
G
V
P
V
V
P
W
V
A
V
R
K
G
E
P
P
V
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
-
F
G
------
E
A
S
P
V
G
E
V
R
---------------------------------
E
-------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
---------------
36
PsiBlast_CBE
61.11
40%
-86
- C1 -
2YZM
1
DDL_THET8
C:
[2-317]
----
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-------
P
F
-
P
T
D
L
A
V
I
A
Q
D
G
----------
R
W
L
L
--------
G
E
K
A
--
L
T
------
A
----------------------------------------------------
L
--
E
-
A
--
K
A
A
P
E
G
E
H
P
-------
F
P
---
P
---
P
L
S
W
E
R
------------
Y
---
D
V
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
-
A
-
G
V
P
V
V
P
W
V
A
V
R
K
G
E
P
P
V
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
-
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
--------------
R
--
A
-
E
-------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
---------------
13
PsiBlast_PDB
60.97
40%
-86
- C1 -
2YZN
1
DDL_THET8
A:
[2-317]
----
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-------
P
F
-
P
T
D
L
A
V
I
A
Q
D
G
----------
R
W
L
L
--------
G
E
K
A
--
L
T
------
A
----------------------------------------------------
L
--
E
-
A
--
K
A
A
P
E
G
E
H
P
-------
F
P
---
P
---
P
L
S
W
E
R
------------
Y
---
D
V
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
-
A
-
G
V
P
V
V
P
W
V
A
V
R
K
G
E
P
P
V
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
--
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
-
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
P
--
G
-
R
--
A
-
E
-------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
---------------
32
PsiBlast_CBE
60.89
40%
-80
- C1 -
2ZDG
2
DDL_THET8
C:
[2-317]
----
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-------
P
F
-
P
T
D
L
A
V
I
A
Q
D
G
----------
R
W
L
L
--------
G
E
K
A
--
L
T
------
A
----------------------------------------------------
L
--
E
-
A
--
K
A
A
P
E
G
E
H
P
-------
F
P
---
P
---
P
L
S
W
E
R
------------
Y
---
D
V
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
-
A
-
G
V
P
V
V
P
W
V
A
V
R
K
G
E
P
P
V
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
-
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
P
--
G
-
R
--
A
-
E
-------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
---------------
31
PsiBlast_CBE
60.13
40%
-88
- C1 -
2ZDG
2
DDL_THET8
D:
[2-317]
----
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-------
P
F
-
P
T
D
L
A
V
I
A
Q
D
G
----------
R
W
L
L
--------
G
E
K
A
--
L
T
------
A
----------------------------------------------------
L
--
E
-
A
--
K
A
A
P
E
G
E
H
P
-------
F
P
---
P
---
P
L
S
W
E
R
------------
Y
---
D
V
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
-
A
-
G
V
P
V
V
P
W
V
A
V
R
K
G
E
P
P
V
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
-
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
-----------------
A
-
E
-------
L
L
I
P
A
P
L
---
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
---------------
62
Fugue
46.99
33%
-77
- C1 -
1IOW
4
?
?:
[97-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
R
S
K
L
L
W
Q
G
-
A
-
G
L
P
V
A
P
W
V
A
L
T
R
A
E
F
E
K
G
L
S
D
K
Q
L
A
E
I
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
-
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
-
I
L
------
P
S
---
I
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
F
L
S
--
D
-
E
--
T
-
Q
-------
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
D
--------------
61
Fugue
44.68
36%
-77
- C1 -
1EHI
4
DDL_LEUMM
A:
[135-362]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
A
L
T
K
E
L
L
T
V
-
N
-
G
I
R
N
T
K
Y
I
V
V
D
P
E
S
A
N
N
W
S
---
W
D
K
I
V
A
E
L
G
N
I
V
F
V
K
A
A
N
Q
G
S
S
V
G
I
S
R
V
T
N
A
E
E
Y
T
E
A
L
S
D
S
F
Q
Y
D
Y
K
V
L
I
E
E
A
V
N
G
-
A
-
R
E
L
E
V
G
V
I
G
N
D
-
Q
P
------
L
V
S
E
I
G
A
H
T
V
P
NQG
S
G
-----
D
G
W
Y
D
Y
N
N
K
F
V
D
--
N
S
A
--
V
-
H
-------
F
Q
I
P
A
Q
L
S
P
E
V
T
K
E
V
K
Q
M
A
L
D
A
Y
K
V
L
N
L
R
G
E
A
R
M
D
F
L
L
D
E
N
N
V
P
Y
L
G
E
P
N
T
L
P
G
F
T
N
M
S
L
F
K
R
L
W
D
Y
S
D
I
N
N
A
K
L
V
D
M
L
I
D
Y
G
F
E
D
F
A
Q
N
K
K
L
S
----
63
Fugue
34.02
34%
-77
- C1 -
1IOW
1
?
?:
[1-96]
-
M
T
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
---
G
-
G
I
-
D
A
Y
P
V
D
P
K
E
V
------------------------------------------------------------------------------------------------------------------
D
V
---
T
---
Q
L
K
S
M
G
------------
F
---
Q
K
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------