@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1896: (2016-03-29 )
MIKPKIALTIAGTDPTGGAGVMADLKSFHSCGVYGMGVVTSIVAQNTLGVQHIHNLNHQWVDEQLDSVFNDTLPHAIKTGMIATADTMETIRHYLMQHESIPYVIDPVMLAKSGDSLMDNDTKQNLQHTLLPLADVVTPNLPEAEEITGLTIDSEEKIMQAGRIFINEIGSKGIIIKGGHSNDTDIAKDYLFTNEGVQTFENERFKTKHTHGTGCTFSAVITAELAKGRPLFEAVHKAKKFISMSIQYTPEIGRGRGPVNHFAYLKKEGLDDELSK
Atome Classification :
(29 SA)
.........10........20........30........40....--...--.50.-.......60........70........80........90........100.......110.......120.......130.......140.......150-........160.......170.......180.......190..-.....200.......210.......220.......230.......240......--.250.--........260........270....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIKP
K
I
A
L
T
I
AGTDPTGG
A
G
V
M
A
D
L
K
S
F
H
SCGV
Y
G
M
G
V
V
T
S
I
V
A
Q--NTL--
G
V
Q
H
-
I
H
NL
N
H
Q
W
V
D
E
Q
L
D
S
V
F
N
DT
L
P
H
A
I
K
TG
M
I
AT
A
D
T
M
E
T
I
R
H
Y
L
M
QHESIPYVI
D
P
V
MLAKSGDSLMDN
D
T
K
Q
N
L
Q
H
T
L
L
P
L
A
D
VVTPNLP
E
A
E
EI
T
G
L
-
T
-ID
S
E
E
K
I
M
Q
A
G
R
I
F
I
N
EIGSK
G
I
I
I
KGGHSN
D
T
D
I
A
K
D
YLFTN-EG
V
Q
T
F
ENERFKTKHTHGTG
C
T
F
S
A
V
I
T
A
E
LAKGR
P
L
F
E
A
V
H
K
A
K
K
F
I
S
M
S
I
Q
Y--TP--E--IGRGRGP
V
N
H
-
F
A
Y
L
K
KEGLDDELSK
4
PsiBlast_PDB
93.18
45%
-83
- C1 -
1UB0
7
?
A:
[2-258]
----
R
V
A
L
T
I
A
G
S
D
S
G
G
G
A
G
V
Q
A
D
L
K
V
F
F
R
F
G
V
Y
G
T
S
A
L
T
L
V
T
A
Q
--
N
T
L
--
G
V
Q
R
-
V
H
L
L
P
P
E
V
V
Y
A
Q
I
E
S
V
A
Q
D
F
P
L
H
A
A
K
T
G
A
L
G
D
A
A
I
V
E
A
V
A
E
A
V
R
R
F
G
V
R
P
L
V
V
D
P
V
M
---------
A
K
E
A
A
A
A
L
K
E
R
L
F
P
L
A
D
L
V
T
P
N
R
L
E
A
E
A
L
L
G
R
-
P
-
I
R
T
L
K
E
A
E
E
A
-
A
K
A
L
L
A
L
G
P
K
A
V
L
L
K
G
G
H
L
---
E
-
A
V
D
L
L
A
T
R
-
G
G
V
L
R
F
S
A
P
R
V
H
T
R
N
T
H
G
T
G
C
T
L
S
A
A
I
A
A
L
L
A
K
G
R
P
L
A
E
A
V
A
E
A
K
A
Y
L
T
R
A
L
K
T
--
A
P
--
S
--
L
G
H
G
H
G
P
L
D
H
-
W
A
-------------
55
HHSearch
92.07
45%
-81
- C1 -
1UB0
7
?
A:
[1-256]
---
M
R
V
A
L
T
I
A
G
S
D
S
G
G
G
A
G
V
Q
A
D
L
K
V
F
F
R
F
G
V
Y
G
T
S
A
L
T
L
V
T
A
Q
--
N
T
L
--
G
V
Q
R
-
V
H
L
L
P
P
E
V
V
Y
A
Q
I
E
S
V
A
Q
D
F
P
L
H
A
A
K
T
G
A
L
G
D
A
A
I
V
E
A
V
A
E
A
V
R
R
F
G
V
R
P
L
V
V
D
P
V
M
---------
A
K
E
A
A
A
A
L
K
E
R
L
F
P
L
A
D
L
V
T
P
N
R
L
E
A
E
A
L
L
G
R
-
P
-
I
R
T
L
-
K
E
A
E
E
A
A
K
A
L
L
A
L
G
P
K
A
V
L
L
K
G
G
H
L
----
E
A
V
D
L
L
A
T
R
-
G
G
V
L
R
F
S
A
P
R
V
H
T
R
N
T
H
G
T
G
C
T
L
S
A
A
I
A
A
L
L
A
K
G
R
P
L
A
E
A
V
A
E
A
K
A
Y
L
T
R
A
L
K
T
--
A
P
--
S
--
L
G
H
G
H
G
P
L
D
H
----------------
2
PsiBlast_PDB
90.15
43%
-86
- C1 -
1JXI
3
THID_SALTY
A:
[28-284]
------
A
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
V
A
E
--
N
T
C
--
G
V
Q
S
-
V
Y
R
I
E
P
D
F
V
A
A
Q
L
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
R
L
Q
R
H
H
V
R
N
V
V
L
D
T
V
M
L
A
K
S
G
D
P
L
L
S
P
S
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
A
-
P
H
A
R
T
E
Q
E
M
L
A
Q
G
R
A
L
L
-
A
M
G
C
E
A
V
L
M
K
G
----------
D
W
L
F
T
R
-
E
G
E
Q
R
F
---
R
V
N
T
K
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
A
Q
AD
T
L
--
E
--
V
G
K
G
I
G
P
V
H
H
-
F
--------------
22
PsiBlast_CBE
89.90
43%
-96
- C1 -
1JXH
2
THID_SALTY
B:
[28-284]
------
A
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
V
A
E
--
N
T
C
--
G
V
Q
S
-
V
Y
R
I
E
P
D
F
V
A
A
Q
L
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
R
L
Q
R
H
H
V
R
N
V
V
L
D
T
V
M
L
------
L
L
S
P
S
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
A
-
P
H
A
R
T
E
Q
E
M
L
A
Q
G
R
A
L
L
-
A
M
G
C
E
A
V
L
M
K
G
----------
D
W
L
F
T
R
-
E
G
E
Q
R
F
---
R
V
N
T
K
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
A
Q
AD
T
L
--
E
--
V
G
K
G
I
G
P
V
H
H
-
F
--------------
1
PsiBlast_PDB
89.73
43%
-96
- C1 -
1JXH
2
THID_SALTY
A:
[28-284]
------
A
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
V
A
E
--
N
T
C
--
G
V
Q
S
-
V
Y
R
I
E
P
D
F
V
A
A
Q
L
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
R
L
Q
R
H
H
V
R
N
V
V
L
D
T
V
M
L
------
L
L
S
P
S
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
A
-
P
H
A
R
T
E
Q
E
M
L
A
Q
G
R
A
L
L
-
A
M
G
C
E
A
V
L
M
K
G
----------
D
W
L
F
T
R
-
E
G
E
Q
R
F
---
R
V
N
T
K
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
A
Q
AD
T
L
--
E
--
V
G
K
G
I
G
P
V
H
H
-
F
--------------
52
HHSearch
89.64
42%
-88
- C1 -
1JXH
2
THID_SALTY
A:
[23-288]
-
M
Q
R
I
N
A
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
V
A
E
--
N
T
C
--
G
V
Q
S
-
V
Y
R
I
E
P
D
F
V
A
A
Q
L
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
R
L
Q
R
H
H
V
R
N
V
V
L
D
T
V
M
L
------
L
L
S
P
S
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
A
-
P
-
H
A
R
T
E
Q
E
M
L
A
Q
G
R
A
L
L
A
M
G
C
E
A
V
L
M
K
G
-----
D
-----
W
L
F
T
R
-
E
G
E
Q
R
F
---
R
V
N
T
K
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
A
Q
--
A
D
--
T
L
E
V
G
K
G
I
G
P
V
H
H
F
H
A
W
W
-----------
21
PsiBlast_CBE
89.55
43%
-87
- C1 -
1JXI
3
THID_SALTY
B:
[28-284]
------
A
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
V
A
E
--
N
T
C
--
G
V
Q
S
-
V
Y
R
I
E
P
D
F
V
A
A
Q
L
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
R
L
Q
R
H
H
V
R
N
V
V
L
D
T
V
M
L
A
K
S
G
D
P
L
L
S
P
S
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
A
-
P
H
A
R
T
E
Q
E
M
L
A
Q
G
R
A
L
L
-
A
M
G
C
E
A
V
L
M
K
G
----------
D
W
L
F
T
R
-
E
G
E
Q
R
F
---
R
V
N
T
K
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
A
Q
AD
T
L
--
E
--
V
G
K
G
I
G
P
V
H
H
-
F
--------------
42
Fugue
88.98
41%
-88
- C1 -
1JXH
2
THID_SALTY
A:
[23-288]
-
M
Q
R
I
N
A
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
V
A
E
--
N
T
C
--
G
V
Q
S
-
V
Y
R
I
E
P
D
F
V
A
A
Q
L
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
R
L
Q
R
H
H
V
R
N
V
V
L
D
T
V
M
L
------
L
L
S
P
S
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
A
-
P
-
H
A
R
T
E
Q
E
M
L
A
Q
G
R
A
L
L
A
M
G
C
E
A
V
L
M
K
G
D
----------
W
L
F
T
R
-
E
G
E
Q
R
F
---
R
V
N
T
K
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
A
Q
--
A
D
T
L
E
--
V
G
K
G
I
G
P
V
H
H
-
F
H
A
W
W
----------
36
PsiBlast_CBE
86.99
35%
-70
- C1 -
4C5K
5
?
D:
[4-275]
----
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
--
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
G
E
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
-
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
-
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
--
G
W
--
K
--
M
N
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
32
PsiBlast_CBE
86.95
35%
-71
- C1 -
4C5M
5
?
C:
[4-275]
----
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
--
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
---
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
-
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
-
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
--
G
W
--
K
--
M
N
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
7
PsiBlast_PDB
86.53
35%
-70
- C1 -
4C5K
4
?
A:
[4-275]
----
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
--
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
--
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
-
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
-
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
--
G
W
--
K
--
M
N
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
40
PsiBlast_CBE
86.43
35%
-68
- C1 -
4C5J
4
?
C:
[4-275]
----
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
--
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
G
E
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
-
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
-
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
--
G
W
--
K
--
M
N
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
28
PsiBlast_CBE
86.08
35%
-71
- C1 -
4C5N
5
?
D:
[4-275]
----
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
--
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
-------
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
-
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
-
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
--
G
W
--
K
--
M
N
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
5
PsiBlast_PDB
86.08
36%
-76
- C1 -
2I5B
1
PDXK_BACSU
A:
[6-264]
------
A
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
V
A
M
D
P
N
N
S
--
W
N
H
Q
-
V
F
P
I
D
T
D
T
I
R
A
Q
L
A
T
I
T
D
G
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
T
I
K
E
K
Q
L
K
N
V
V
I
D
P
V
M
V
C
K
G
A
N
E
V
L
Y
P
E
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
L
S
G
M
D
E
-
L
K
T
V
D
D
M
I
E
A
A
K
-
K
I
H
A
L
G
A
Q
Y
V
V
I
T
G
G
G
K
L
K
H
E
K
A
V
D
V
L
Y
D
G
-
E
T
A
E
V
L
E
S
E
M
I
D
T
P
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
K
E
--
S
F
--
P
--
L
N
Q
Y
V
G
P
T
K
H
-
S
A
-------------
37
PsiBlast_CBE
86.07
35%
-71
- C1 -
4C5K
4
?
C:
[4-275]
----
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
--
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
------
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
-
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
-
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
--
G
W
--
K
--
M
N
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
30
PsiBlast_CBE
85.87
35%
-73
- C1 -
4C5N
4
?
B:
[4-275]
----
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
--
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
-------
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
-
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
-
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
--
G
W
--
K
--
M
N
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
6
PsiBlast_PDB
85.73
35%
-68
- C1 -
4C5J
3
?
A:
[4-275]
----
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
--
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
G
E
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
-
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
-
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
--
G
W
--
K
--
M
N
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
31
PsiBlast_CBE
85.71
35%
-67
- C1 -
4C5M
6
?
D:
[4-275]
----
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
--
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
---
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
-
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
-
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
--
G
W
--
K
--
M
N
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
33
PsiBlast_CBE
85.69
35%
-70
- C1 -
4C5M
5
?
B:
[4-275]
----
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
--
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
G
E
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
-
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
-
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
--
G
W
--
K
--
M
N
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
38
PsiBlast_CBE
85.67
35%
-70
- C1 -
4C5K
4
?
B:
[4-275]
----
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
--
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
--
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
-
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
-
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
--
G
W
--
K
--
M
N
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
26
PsiBlast_CBE
85.51
36%
-75
- C1 -
2I5B
1
PDXK_BACSU
C:
[6-264]
------
A
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
V
A
M
D
P
N
N
S
--
W
N
H
Q
-
V
F
P
I
D
T
D
T
I
R
A
Q
L
A
T
I
T
D
G
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
T
I
K
E
K
Q
L
K
N
V
V
I
D
P
V
M
V
C
K
G
A
N
E
V
L
Y
P
E
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
L
S
G
M
D
E
-
L
K
T
V
D
D
M
I
E
A
A
K
-
K
I
H
A
L
G
A
Q
Y
V
V
I
T
G
G
G
K
L
K
H
E
K
A
V
D
V
L
Y
D
G
-
E
T
A
E
V
L
E
S
E
M
I
D
T
P
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
K
E
--
S
F
--
P
--
L
N
Q
Y
V
G
P
T
K
H
-
S
A
-------------
53
HHSearch
85.10
36%
-69
* C1 *
2I5B
1
PDXK_BACSU
A:
[3-268]
---
M
H
K
A
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
V
A
M
--
D
P
N
NS
W
N
H
Q
-
V
F
P
I
D
T
D
T
I
R
A
Q
L
A
T
I
T
D
G
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
T
I
K
E
K
Q
L
K
N
V
V
I
D
P
V
M
V
C
K
G
A
N
E
V
L
Y
P
E
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
L
S
G
M
-
D
-
E
L
K
T
V
D
D
M
I
E
A
A
K
K
I
H
A
L
G
A
Q
Y
V
V
I
T
G
G
G
K
L
K
H
E
K
A
V
D
V
L
Y
D
G
-
E
T
A
E
V
L
E
S
E
M
I
D
T
P
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
K
E
--
S
F
--
P
--
L
N
Q
Y
V
G
P
T
K
H
-
S
A
L
R
L
N
---------
10
PsiBlast_PDB
85.00
35%
-70
- C1 -
4C5N
2
?
A:
[4-275]
----
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
--
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
--------
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
-
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
-
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
--
G
W
--
K
--
M
N
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
25
PsiBlast_CBE
84.83
36%
-75
- C1 -
2I5B
1
PDXK_BACSU
D:
[6-264]
------
A
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
V
A
M
DP
N
N
S
--
W
N
H
Q
-
V
F
P
I
D
T
D
T
I
R
A
Q
L
A
T
I
T
D
G
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
T
I
K
E
K
Q
L
K
N
V
V
I
D
P
V
M
V
C
K
G
A
N
E
V
L
Y
P
E
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
L
S
G
M
D
E
-
L
K
T
V
D
D
M
I
E
A
A
K
-
K
I
H
A
L
G
A
Q
Y
V
V
I
T
G
G
G
K
L
K
H
E
K
A
V
D
V
L
Y
D
G
-
E
T
A
E
V
L
E
S
E
M
I
D
T
P
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
K
E
--
S
F
--
P
--
L
N
Q
Y
V
G
P
T
K
H
-
S
A
-------------
29
PsiBlast_CBE
84.62
35%
-71
- C1 -
4C5N
4
?
C:
[4-275]
----
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
--
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
---------
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
-
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
-
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
--
G
W
--
K
--
M
N
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
35
PsiBlast_CBE
83.77
35%
-64
- C1 -
4C5L
1
?
C:
[4-275]
----
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
--
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
G
-----
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
-
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
-
Q
T
F
Y
Q
L
T
T
D
M
F
Q
--
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
--
G
W
--
K
--
M
N
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
34
PsiBlast_CBE
83.64
35%
-65
- C1 -
4C5L
2
?
D:
[4-275]
----
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
--
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
G
-----
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
-
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
-
Q
T
F
Y
Q
L
T
T
D
M
F
Q
--
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
--
G
W
--
K
--
M
N
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
8
PsiBlast_PDB
83.27
35%
-72
- C1 -
4C5L
3
?
A:
[4-275]
----
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
--
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
G
E
----
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
-
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
------
K
S
Y
D
L
Y
Y
D
G
-
Q
T
F
Y
Q
L
T
T
D
M
F
--
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
--
G
W
--
K
--
M
N
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
11
PsiBlast_PDB
71.74
30%
-81
- C1 -
4YL5
2
?
A:
[9-242]
-
V
R
P
T
V
-
L
C
F
S
G
L
D
P
S
G
G
A
G
L
Q
A
D
I
E
A
I
G
Q
S
G
A
H
A
A
I
A
C
T
A
L
T
I
Q
--
N
S
Q
--
Q
V
F
G
-
F
E
A
T
S
K
E
L
L
L
A
Q
A
N
A
V
V
G
D
L
P
I
K
C
V
K
S
G
M
L
G
T
T
D
N
I
A
A
L
A
E
F
L
R
A
H
P
D
Y
Q
Y
V
L
D
P
V
L
V
A
N
S
G
G
S
L
G
D
Q
A
T
L
V
K
A
F
V
E
L
I
P
L
A
T
L
I
T
P
N
T
V
E
L
R
A
L
T
G
V
-
T
D
L
D
Q
A
T
Q
-----
K
L
F
--
E
M
G
A
K
A
V
L
V
K
G
G
H
E
D
T
P
D
F
I
K
N
S
L
Y
I
D
G
E
L
A
A
S
S
T
C
P
-----------
C
S
L
A
S
F
I
A
G
R
L
A
L
G
D
S
L
K
I
A
V
Q
H
A
E
T
W
L
-----------------------------------------