@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1915: (2016-03-30 )
MSYITKQDKVIAEAIEREFQRQNSNIELIASENFVSEAVMEAQGSVLTNKYAEGYPGRRYYGGCEFVDVTESIAIDRAKALFGAEHVNVQPHSGSQANMAVYLVALEMGDTVLGMNLSHGGHLTHGAPVNFSGKFYNFVEYGVDKDTERINYDEVRKLALEHKPKLIVAGASAYSRTIDFKKFKEIADEVNAKLMVDMAHIAGLVAAGLHPNPVEYADFVTTTTHKTLRGPRGGMILCKEEYKKDIDKTIFPGIQGGPLEHVIAAKAVAFGEALENNFKTYQQQVVKNAKVLAEALINEGFRIVSGGTDNHLVAVDVKGSIGLTGKEAEETLDSVGITCNKNTIPFDQEKPFVTSGIRLGTPAATTRGFDEKAFEEVAKIISLALKNSKDEEKLQQAKERVAKLTAEYPLYQ
Atome Classification :
(69 SA)
------------.........10........20........30........40........50........60........70........80....----.----...90........100.......110.......120....-----..-------.130.......140--.......150.......160.......170.......180.......190.......200.......210.......220.......230......-.---240-------------.--------....---------------....250......-.260.......270.......280.......290....-...300.......310.......320.......330.......340.......350.......360.......370.......380--.---------------------........390---------------------.------------------------........400.......410-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MSYI
T
K
Q
D
K
V
I
A
E
A
I
E
R
E
F
Q
RQNS
N
I
E
L
I
ASE
N
F
V
S
E
A
V
M
E
AQG
S
V
L
T
N
K
YAEGYPGRRYYGG
C
E
F
V
D
V
T
E
S
I
A
I
D
R
A
K
A
L
FGAE----
H
----
V
N
VQPHSGSQA
N
M
A
V
Y
L
V
A
L
EMG
D
T
V
L
G
M
NLSHGGHLTHG-----AP-------VNFSGK
F
Y
N
F
V
E
YG--VDKDTERI
N
Y
D
E
V
R
K
L
A
L
EHKP
K
L
I
V
AGASAYSRTI
D
F
K
K
F
K
E
I
A
D
EVN
A
K
L
M
V
D
M
A
H
I
A
G
L
V
A
AGLHPNP
V
E
Y
A
D
F
V
T
TTTHKTLRGPRG
G
M
I
L
C
-
K
---
E
---------------
E
--------
Y
K
K
D
---------------
I
D
K
T
IFPGIQGG
P
-
L
E
H
V
I
A
A
K
A
V
A
F
G
E
A
L
E
N
N
F
K
T
Y
Q
Q
Q
V
V
K
N
A
K
V
L
A
E
A
L
-
I
NEG
F
R
I
VSGGTD
N
H
L
V
A
V
D
VKGSIGLTG
K
E
A
E
E
T
L
D
SVG
I
T
CNKNTIPFDQEKPFVTS
G
I
RLGTPAATTRGF
D
E
K
A
F
E
E
V
A
K
I
----
I
---------------------
S
L
A
LKNSK
D
-----------------------
E
------------------------
E
K
L
Q
Q
A
K
E
R
V
A
K
L
T
AEYPLYQ-
22
PsiBlast_CBE
98.20
99%
-89
- C1 -
3PGY
5
GLYA_STAAC
C:
[4-414]
------------
M
S
Y
I
T
K
Q
D
K
V
I
A
E
A
I
E
R
E
F
Q
R
Q
N
S
N
I
E
L
I
A
S
E
N
F
V
S
E
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
--
G
G
C
E
F
V
D
V
T
E
S
I
A
I
D
R
A
K
A
L
F
G
A
E
----
H
----
V
N
V
Q
P
H
S
G
P
Q
A
N
M
A
V
Y
L
V
A
L
E
M
G
D
T
V
L
G
M
N
------------------------
V
N
F
S
G
K
F
Y
N
F
V
E
Y
G
--
V
D
K
D
T
E
R
I
N
Y
D
E
V
R
K
L
A
L
E
H
K
P
K
L
I
V
A
G
A
S
A
Y
S
R
T
I
D
F
K
K
F
K
E
I
A
D
E
V
N
A
K
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
E
Y
A
D
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
K
---
E
---------------
E
--------
Y
K
K
D
---------------
I
D
K
T
I
F
P
G
I
Q
G
G
P
-
L
E
H
V
I
A
A
K
A
V
A
F
G
E
A
L
E
N
N
F
K
T
Y
Q
Q
Q
V
V
K
N
A
K
V
L
A
E
A
L
-
I
N
E
G
F
R
I
V
S
G
G
T
D
N
H
L
V
A
V
D
V
K
G
S
I
G
L
T
G
K
E
A
E
E
T
L
D
S
V
G
I
T
C
N
K
N
T
I
P
F
D
Q
E
K
P
F
V
T
S
G
I
R
L
G
T
P
A
A
T
T
R
G
F
D
E
K
A
F
E
E
V
A
K
I
----
I
---------------------
S
L
A
L
K
N
S
K
D
-----------------------
E
------------------------
E
K
L
Q
Q
A
K
E
R
V
A
K
L
T
A
E
Y
P
L
Y
--
1
PsiBlast_PDB
97.34
99%
-87
- C1 -
3PGY
4
GLYA_STAAC
A:
[4-415]
------------
M
S
Y
I
T
K
Q
D
K
V
I
A
E
A
I
E
R
E
F
Q
R
Q
N
S
N
I
E
L
I
A
S
E
N
F
V
S
E
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
--
G
G
C
E
F
V
D
V
T
E
S
I
A
I
D
R
A
K
A
L
F
G
A
E
----
H
----
V
N
V
Q
P
H
S
G
P
Q
A
N
M
A
V
Y
L
V
A
L
E
M
G
D
T
V
L
G
M
N
L
S
H
-------------
P
-------
V
N
F
S
G
K
F
Y
N
F
V
E
Y
G
--
V
D
K
D
T
E
R
I
N
Y
D
E
V
R
K
L
A
L
E
H
K
P
K
L
I
V
A
G
A
S
A
Y
S
R
T
I
D
F
K
K
F
K
E
I
A
D
E
V
N
A
K
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
E
Y
A
D
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
K
---
E
---------------
E
--------
Y
K
K
D
---------------
I
D
K
T
I
F
P
G
I
Q
G
G
P
-
L
E
H
V
I
A
A
K
A
V
A
F
G
E
A
L
E
N
N
F
K
T
Y
Q
Q
Q
V
V
K
N
A
K
V
L
A
E
A
L
-
I
N
E
G
F
R
I
V
S
G
G
T
D
N
H
L
V
A
V
D
V
K
G
S
I
G
L
T
G
K
E
A
E
E
T
L
D
S
V
G
I
T
C
N
K
N
T
I
P
F
D
Q
E
K
P
F
V
T
S
G
I
R
L
G
T
P
A
A
T
T
R
G
F
D
E
K
A
F
E
E
V
A
K
I
----
I
---------------------
S
L
A
L
K
N
S
K
D
-----------------------
E
------------------------
E
K
L
Q
Q
A
K
E
R
V
A
K
L
T
A
E
Y
P
L
Y
Q
-
21
PsiBlast_CBE
96.78
99%
-89
- C1 -
3PGY
4
GLYA_STAAC
D:
[4-414]
------------
M
S
Y
I
T
K
Q
D
K
V
I
A
E
A
I
E
R
E
F
Q
R
Q
N
S
N
I
E
L
I
A
S
E
N
F
V
S
E
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
F
V
D
V
T
E
S
I
A
I
D
R
A
K
A
L
F
G
A
E
----
H
----
V
N
V
Q
P
H
S
G
P
Q
A
N
M
A
V
Y
L
V
A
L
E
M
G
D
T
V
L
G
M
N
----------------
P
-------
V
N
F
S
G
K
F
Y
N
F
V
E
Y
G
--
V
D
K
D
T
E
R
I
N
Y
D
E
V
R
K
L
A
L
E
H
K
P
K
L
I
V
A
G
A
S
A
Y
S
R
T
I
D
F
K
K
F
K
E
I
A
D
E
V
N
A
K
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
E
Y
A
D
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
K
---
E
---------------
E
--------
Y
K
K
D
---------------
I
D
K
T
I
F
P
G
I
Q
G
G
P
-
L
E
H
V
I
A
A
K
A
V
A
F
G
E
A
L
E
N
N
F
K
T
Y
Q
Q
Q
V
V
K
N
A
K
V
L
A
E
A
L
-
I
N
E
G
F
R
I
V
S
G
G
T
D
N
H
L
V
A
V
D
V
K
G
S
I
G
L
T
G
K
E
A
E
E
T
L
D
S
V
G
I
T
C
N
K
N
T
I
P
F
D
Q
E
K
P
F
V
T
S
G
I
R
L
G
T
P
A
A
T
T
R
G
F
D
E
K
A
F
E
E
V
A
K
I
----
I
---------------------
S
L
A
L
K
N
S
K
D
-----------------------
E
------------------------
E
K
L
Q
Q
A
K
E
R
V
A
K
L
T
A
E
Y
P
L
Y
--
23
PsiBlast_CBE
96.14
99%
-86
- C1 -
3PGY
6
GLYA_STAAC
B:
[4-414]
------------
M
S
Y
I
T
K
Q
D
K
V
I
A
E
A
I
E
R
E
F
Q
R
Q
N
S
N
I
E
L
I
A
S
E
N
F
V
S
E
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
F
V
D
V
T
E
S
I
A
I
D
R
A
K
A
L
F
G
A
E
----
H
----
V
N
V
Q
P
H
S
G
P
Q
A
N
M
A
V
Y
L
V
A
L
E
M
G
D
T
V
L
G
M
N
L
S
H
------------
A
P
-------
V
N
F
S
G
K
F
Y
N
F
V
E
Y
G
--
V
D
K
D
T
E
R
I
N
Y
D
E
V
R
K
L
A
L
E
H
K
P
K
L
I
V
A
G
A
S
A
Y
S
R
T
I
D
F
K
K
F
K
E
I
A
D
E
V
N
A
K
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
E
Y
A
D
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
K
---
E
---------------
E
--------
Y
K
K
D
---------------
I
D
K
T
I
F
P
G
I
Q
G
G
P
-
L
E
H
V
I
A
A
K
A
V
A
F
G
E
A
L
E
N
N
F
K
T
Y
Q
Q
Q
V
V
K
N
A
K
V
L
A
E
A
L
-
I
N
E
G
F
R
I
V
S
G
G
T
D
N
H
L
V
A
V
D
V
K
G
S
I
G
L
T
G
K
E
A
E
E
T
L
D
S
V
G
I
T
C
N
K
N
T
I
P
F
D
Q
E
K
P
F
V
T
S
G
I
R
L
G
T
P
A
A
T
T
R
G
F
D
E
K
A
F
E
E
V
A
K
I
----
I
---------------------
S
L
A
L
K
N
S
K
D
-----------------------
E
------------------------
E
K
L
Q
Q
A
K
E
R
V
A
K
L
T
A
E
Y
P
L
Y
--
39
PsiBlast_CBE
89.58
71%
-77
- C1 -
2VMR
3
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
A
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
37
PsiBlast_CBE
89.40
71%
-76
- C1 -
2VMT
4
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
A
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
14
PsiBlast_PDB
89.39
71%
-78
- C1 -
2VI8
4
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
31
PsiBlast_CBE
89.23
71%
-77
- C1 -
2W7M
2
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
34
PsiBlast_CBE
89.02
71%
-74
- C1 -
2W7J
2
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
29
PsiBlast_CBE
89.00
71%
-76
- C1 -
2VMO
5
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
11
PsiBlast_PDB
88.98
71%
-76
- C1 -
2VGU
4
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
28
PsiBlast_CBE
88.87
71%
-76
- C1 -
2VMP
5
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
8
PsiBlast_PDB
88.82
71%
-76
- C1 -
2VGT
4
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
33
PsiBlast_CBE
88.81
71%
-76
- C1 -
2W7K
2
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
18
PsiBlast_PDB
88.79
71%
-77
- C1 -
2W7D
3
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
F
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
30
PsiBlast_CBE
88.77
71%
-75
- C1 -
2VMN
4
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
38
PsiBlast_CBE
88.76
71%
-75
- C1 -
2VMS
4
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
A
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
27
PsiBlast_CBE
88.70
71%
-76
- C1 -
2VMQ
6
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
15
PsiBlast_PDB
88.68
71%
-76
- C1 -
2VIB
5
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
5
PsiBlast_PDB
88.62
72%
-76
- C1 -
1KL2
6
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
19
PsiBlast_PDB
88.54
71%
-76
- C1 -
2W7E
4
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
F
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
45
PsiBlast_CBE
88.46
71%
-76
- C1 -
2VMV
2
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
40
PsiBlast_CBE
88.45
71%
-77
- C1 -
2VMZ
3
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
35
PsiBlast_CBE
88.37
71%
-74
- C1 -
2W7I
1
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
25
PsiBlast_CBE
88.35
71%
-76
- C1 -
2W7H
4
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
F
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
44
PsiBlast_CBE
88.33
71%
-75
- C1 -
2VMW
5
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
2
PsiBlast_PDB
88.30
72%
-76
- C1 -
1KKJ
1
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
42
PsiBlast_CBE
88.28
71%
-77
- C1 -
2VMY
7
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
26
PsiBlast_CBE
88.28
71%
-75
- C1 -
2W7G
4
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
F
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
16
PsiBlast_PDB
88.28
71%
-76
- C1 -
2VIA
5
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
36
PsiBlast_CBE
88.27
71%
-73
- C1 -
2VMU
4
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
A
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
9
PsiBlast_PDB
88.23
71%
-76
- C1 -
2VGV
3
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
32
PsiBlast_CBE
88.21
71%
-75
- C1 -
2W7L
2
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
20
PsiBlast_PDB
88.21
71%
-75
- C1 -
2W7F
5
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
F
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
4
PsiBlast_PDB
88.15
72%
-77
- C1 -
1KL1
2
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
43
PsiBlast_CBE
88.12
71%
-76
- C1 -
2VMX
3
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
10
PsiBlast_PDB
88.00
71%
-75
- C1 -
2VGW
4
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
7
PsiBlast_PDB
87.93
71%
-76
- C1 -
2VGS
2
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
13
PsiBlast_PDB
87.89
71%
-77
- C1 -
1YJZ
1
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
M
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
17
PsiBlast_PDB
87.86
71%
-74
- C1 -
2VI9
5
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
3
PsiBlast_PDB
87.86
72%
-74
- C1 -
1KKP
2
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
114
HHSearch
87.75
71%
-76
- C1 -
2VI8
4
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
--
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
-
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
24
PsiBlast_CBE
87.75
72%
-75
- C1 -
1KL2
6
?
B:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
12
PsiBlast_PDB
87.74
71%
-77
- C1 -
1YJY
1
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
M
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
41
PsiBlast_CBE
87.56
71%
-75
- C1 -
2VMY
7
?
B:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
6
PsiBlast_PDB
87.09
71%
-75
- C1 -
1YJS
1
?
A:
[1-404]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
--
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
Q
T
L
R
G
P
R
G
G
M
I
L
C
-
Q
---
E
---------------
Q
--------
F
A
K
Q
---------------
I
D
K
A
I
F
P
G
I
Q
G
G
P
-
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
----
I
---------------------
G
L
V
L
K
N
V
G
S
-----------------------
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
47
PsiBlast_CBE
85.18
64%
-74
- C1 -
2DKJ
4
GLYA_THET8
A:
[6-406]
-----------------
K
R
D
E
A
L
F
E
L
I
A
L
E
E
K
R
Q
R
E
G
L
E
L
I
A
S
E
N
F
V
S
K
Q
V
R
E
A
V
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
A
R
Y
Y
G
G
C
E
V
I
D
R
V
E
S
L
A
I
E
R
A
K
A
L
F
G
A
A
----
W
----
A
N
V
Q
P
H
S
G
S
Q
A
N
M
A
V
Y
M
A
L
M
E
P
G
D
T
L
M
G
M
D
L
A
A
G
G
H
L
T
H
G
-----
S
R
-------
V
N
F
S
G
K
L
Y
K
V
V
S
Y
G
--
V
R
P
D
T
E
L
I
D
L
E
E
V
R
R
L
A
L
E
H
R
P
K
V
I
V
A
G
A
S
A
Y
P
R
F
W
D
F
K
A
F
R
E
I
A
D
E
V
G
A
Y
L
V
V
D
M
A
H
F
A
G
L
V
A
A
G
L
H
P
N
P
L
P
Y
A
H
V
V
T
S
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
S
-
N
---
D
P
--------------
E
--------
L
G
K
R
---------------
I
D
K
L
I
F
P
G
I
Q
G
G
P
-
L
E
H
V
I
A
G
K
A
V
A
F
F
E
A
L
Q
P
E
F
K
E
Y
S
R
L
V
V
E
N
A
K
R
L
A
E
E
L
-
A
R
R
G
Y
R
I
V
T
G
G
T
D
N
H
L
F
L
V
D
L
R
P
K
-
G
L
T
G
K
E
A
E
E
R
L
D
A
V
G
I
T
V
N
K
N
A
I
P
F
D
P
K
P
P
R
V
T
S
G
I
R
I
G
T
P
A
I
T
T
R
G
F
T
P
E
E
M
P
L
V
A
E
L
----
I
---------------------
D
R
A
L
L
E
G
P
S
-----------------------
E
----------------------------
A
L
R
E
E
V
R
R
L
A
L
A
H
P
M
---
73
PsiBlast_CBE
85.16
59%
-75
- C1 -
4WXG
3
GLYA_STRT1
C:
[24-428]
-------------------
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
A
K
----
F
----
A
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
-----
A
P
-------
V
S
F
S
G
K
T
Y
N
F
V
S
Y
N
--
V
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
I
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
T
D
D
---
E
---------------
D
--------
I
A
K
K
---------------
L
N
S
A
V
F
P
G
L
Q
G
G
P
-
L
E
H
V
I
A
A
K
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
-
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
E
A
E
S
R
Q
I
A
E
W
----
M
---------------------
V
E
A
L
E
N
H
D
K
-----------------------
P
------------------------
E
V
L
E
R
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
--
74
PsiBlast_CBE
84.51
59%
-76
- C1 -
4WXG
4
GLYA_STRT1
A:
[24-428]
-------------------
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
A
K
----
F
----
A
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
-----
A
P
-------
V
S
F
S
G
K
T
Y
N
F
V
S
Y
N
--
V
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
I
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
T
D
D
---
E
---------------
D
--------
I
A
K
K
---------------
L
N
S
A
V
F
P
G
L
Q
G
G
P
-
L
E
H
V
I
A
A
K
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
-
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
E
A
E
S
R
Q
I
A
E
W
----
M
---------------------
V
E
A
L
E
N
H
D
K
-----------------------
P
------------------------
E
V
L
E
R
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
--
46
PsiBlast_CBE
84.27
64%
-76
- C1 -
2DKJ
4
GLYA_THET8
B:
[6-406]
-----------------
K
R
D
E
A
L
F
E
L
I
A
L
E
E
K
R
Q
R
E
G
L
E
L
I
A
S
E
N
F
V
S
K
Q
V
R
E
A
V
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
A
R
Y
Y
G
G
C
E
V
I
D
R
V
E
S
L
A
I
E
R
A
K
A
L
F
G
A
A
----
W
----
A
N
V
Q
P
H
S
G
S
Q
A
N
M
A
V
Y
M
A
L
M
E
P
G
D
T
L
M
G
M
D
L
A
A
G
G
H
L
T
H
G
-----
S
R
-------
V
N
F
S
G
K
L
Y
K
V
V
S
Y
G
--
V
R
P
D
T
E
L
I
D
L
E
E
V
R
R
L
A
L
E
H
R
P
K
V
I
V
A
G
A
S
A
Y
P
R
F
W
D
F
K
A
F
R
E
I
A
D
E
V
G
A
Y
L
V
V
D
M
A
H
F
A
G
L
V
A
A
G
L
H
P
N
P
L
P
Y
A
H
V
V
T
S
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
S
-
N
---
D
P--------------
E
--------
L
G
K
R
---------------
I
D
K
L
I
F
P
G
I
Q
G
G
P
-
L
E
H
V
I
A
G
K
A
V
A
F
F
E
A
L
Q
P
E
F
K
E
Y
S
R
L
V
V
E
N
A
K
R
L
A
E
E
L
-
A
R
R
G
Y
R
I
V
T
G
G
T
D
N
H
L
F
L
V
D
L
R
P
K
-
G
L
T
G
K
E
A
E
E
R
L
D
A
V
G
I
T
V
N
K
N
A
I
P
F
D
P
K
P
P
R
V
T
S
G
I
R
I
G
T
P
A
I
T
T
R
G
F
T
P
E
E
M
P
L
V
A
E
L
----
I
---------------------
D
R
A
L
L
E
G
P
S
-----------------------
E
----------------------------
A
L
R
E
E
V
R
R
L
A
L
A
H
P
M
---
75
PsiBlast_CBE
84.23
59%
-74
- C1 -
4WXF
2
GLYA_STRT1
C:
[24-428]
-------------------
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
A
K
----
F
----
A
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
-----
A
P
-------
V
S
F
S
G
K
T
Y
N
F
V
S
Y
N
--
V
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
I
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
T
D
D
---
E
---------------
D
--------
I
A
K
K
---------------
L
N
S
A
V
F
P
G
L
Q
G
G
P
-
L
E
H
V
I
A
A
K
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
-
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
E
A
E
S
R
Q
I
A
E
W
----
M
---------------------
V
E
A
L
E
N
H
D
K
-----------------------
P
------------------------
E
V
L
E
R
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
--
76
PsiBlast_CBE
83.74
59%
-76
- C1 -
4WXF
4
GLYA_STRT1
A:
[24-428]
-------------------
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
A
K
----
F
----
A
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
-----
A
P
-------
V
S
F
S
G
K
T
Y
N
F
V
S
Y
N
--
V
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
I
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
T
D
D
---
E
---------------
D
--------
I
A
K
K
---------------
L
N
S
A
V
F
P
G
L
Q
G
G
P
-
L
E
H
V
I
A
A
K
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
-
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
E
A
E
S
R
Q
I
A
E
W
----
M
---------------------
V
E
A
L
E
N
H
D
K
-----------------------
P
------------------------
E
V
L
E
R
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
--
117
HHSearch
82.44
62%
-74
* C1 *
2DKJ
4
GLYA_THET8
A:
[6-405]
-----------------
K
R
D
E
A
L
F
E
L
I
A
L
E
E
K
R
Q
R
E
G
L
E
L
I
A
S
E
N
F
V
S
K
Q
V
R
E
A
V
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
A
R
Y
Y
G
G
C
E
V
I
D
R
V
E
S
L
A
I
E
R
A
K
A
L
F
G
A
A
----
W
----
A
N
V
Q
P
H
S
G
S
Q
A
N
M
A
V
Y
M
A
L
M
E
P
G
D
T
L
M
G
M
D
L
A
A
G
G
H
L
T
H
G
-----
S
R
-------
V
N
F
S
G
K
L
Y
K
V
V
S
Y
G
--
V
R
P
D
T
E
L
I
D
L
E
E
V
R
R
L
A
L
E
H
R
P
K
V
I
V
A
G
A
S
A
Y
P
R
F
W
D
F
K
A
F
R
E
I
A
D
E
V
G
A
Y
L
V
V
D
M
A
H
F
A
G
L
V
A
A
G
L
H
P
N
P
L
P
Y
A
H
V
V
T
S
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
S
-
N
D--
P
---------------
E
--------
L
G
K
R
---------------
I
D
K
L
I
F
P
G
I
Q
G
G
P
L
E
H
V
I
A
G
K
A
V
A
F
F
E
A
L
Q
-
P
E
F
K
E
Y
S
R
L
V
V
E
N
A
K
R
L
A
E
E
L
-
A
R
R
G
Y
R
I
V
T
G
G
T
D
N
H
L
F
L
V
D
L
R
P
K
G
-
L
T
G
K
E
A
E
E
R
L
D
A
V
G
I
T
V
N
K
N
A
I
P
F
D
P
K
P
P
R
V
T
S
G
I
R
I
G
T
P
A
I
T
T
R
G
F
T
P
E
E
M
P
L
V
A
E
L
----
I
---------------------
D
R
A
L
L
E
G
P
S
---------------------------------------------------
E
A
L
R
E
E
V
R
R
L
A
L
A
H
P
----
68
PsiBlast_CBE
79.57
59%
-72
- C1 -
3G8M
1
GLYA_ECOLI
A:
[8-416]
---------------
I
A
D
Y
D
A
E
L
W
Q
A
M
E
Q
E
K
V
R
Q
E
E
H
I
E
L
I
A
S
E
N
Y
T
S
P
R
V
M
Q
A
Q
G
S
Q
L
T
N
K
F
A
E
G
Y
P
G
K
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
Q
L
A
I
D
R
A
K
E
L
F
G
A
D
----
Y
----
A
N
V
Q
P
H
S
G
S
Q
A
N
F
A
V
Y
T
A
L
L
E
P
G
D
T
V
L
G
M
N
L
A
H
G
G
H
L
T
H
G
-----
S
P
-------
V
N
F
S
G
K
L
Y
N
I
V
P
Y
G
--
I
D
A
-
T
G
H
I
D
Y
A
D
L
E
K
Q
A
K
E
H
K
P
K
M
I
I
G
G
F
S
A
Y
S
G
V
V
D
W
A
K
M
R
E
I
A
D
S
I
G
A
Y
L
F
V
D
M
A
H
V
A
G
L
V
A
A
G
V
Y
P
N
P
V
P
H
A
H
V
V
T
T
T
T
H
K
T
L
A
G
P
R
G
G
L
I
L
A
-
K
GGS
E
---------------
E
--------
L
Y
K
K
---------------
L
N
S
A
V
F
P
G
G
Q
G
G
P
-
L
M
H
V
I
A
G
K
A
V
A
L
K
E
A
M
E
P
E
F
K
T
Y
Q
Q
Q
V
A
K
N
A
K
A
M
V
E
V
F
-
L
E
R
G
Y
K
V
V
S
G
G
T
D
N
H
L
F
L
V
D
L
V
D
K
-
N
L
T
G
K
E
A
D
A
A
L
G
R
A
N
I
T
V
N
K
N
S
V
P
N
D
P
K
S
P
F
V
T
S
G
I
R
V
G
T
P
A
I
T
R
R
G
F
K
E
A
E
A
K
E
L
A
G
W
----
M
---------------------
C
D
V
L
D
S
I
N
D
-----------------------
E
------------------------
A
V
I
E
R
I
K
G
K
V
L
D
I
C
A
R
Y
P
V
Y
--
102
Fugue
79.15
46%
-73
- C1 -
1BJ4
1
GLYC_HUMAN
A:
[1-470]
DA
D
L
W
S
S
H
D
A
M
L
A
Q
P
L
K
D
S
D
V
E
V
Y
N
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
Q
R
Y
Y
G
G
T
E
F
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
K
L
D
PQC
W
G
----
V
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-------
I
S
A
T
S
I
F
F
E
S
M
P
Y
K
--
V
N
P
D
T
G
Y
I
N
Y
D
Q
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
E
Y
A
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
A
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
-
R
---
K
G
VKSVDPATG
K
E
I
L
Y
N
--------
L
E
S
L
---------------
I
N
S
A
V
F
P
G
L
Q
G
G
P
-
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
L
E
F
K
V
Y
Q
H
Q
V
V
A
N
C
R
A
L
S
E
A
L
-
T
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
-
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
R
S
-
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
----
I
---------------------
H
R
G
I
E
L
T
L
Q
I
Q
S
D
T
GVAAT
L
K
E
F
K
E
R
L
A
GDKY
Q
------------------------
A
A
V
Q
A
L
R
E
E
V
E
S
F
A
S
L
F
P
L
P
G
L
81
PsiBlast_CBE
78.22
41%
-80
- C1 -
4PVF
2
GLYM_HUMAN
B:
[28-477]
---------------
L
S
D
S
D
P
E
M
W
E
L
L
Q
R
E
K
D
R
Q
C
R
G
L
E
L
I
A
S
E
N
F
C
S
R
A
A
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
K
R
Y
Y
G
G
A
E
V
V
D
E
I
E
L
L
C
Q
R
R
A
L
E
A
F
D
L
D
----
P
AQWG
V
N
V
Q
P
Y
S
G
S
P
A
N
L
A
V
Y
T
A
L
L
Q
P
H
D
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
YMSDV
K
R
-------
I
S
A
T
S
I
F
F
E
S
M
P
Y
K
--
L
N
P
K
T
G
L
I
D
Y
N
Q
L
A
L
T
A
R
L
F
R
P
R
L
I
I
A
G
T
S
A
Y
A
R
L
I
D
Y
A
R
M
R
E
V
C
D
E
V
K
A
H
L
L
A
D
M
A
H
I
S
G
L
V
A
A
K
V
I
P
S
P
F
K
H
A
D
I
V
T
T
T
T
H
K
T
L
R
G
A
R
S
G
L
I
F
Y
-
R
---
K
GVKAIPY--------
T
--------
F
E
D
R
---------------
I
N
F
A
V
F
P
S
L
Q
G
G
P
-
H
N
H
A
I
A
A
V
A
V
A
L
K
Q
A
C
T
P
M
F
R
E
Y
S
L
Q
V
L
K
N
A
R
A
M
A
D
A
L
-
L
E
R
G
Y
S
L
V
S
G
G
T
D
N
H
L
V
L
V
D
L
R
P
K
-
G
L
D
G
A
R
A
E
R
V
L
E
L
V
S
I
T
A
N
K
N
T
C
--------
T
P
G
G
L
R
L
G
A
P
A
L
T
S
R
Q
F
R
E
D
D
F
R
R
V
V
D
F
----
I
DEGVNIGLEVKSKTAKLQDFK
S
F
L
L
K
D
S
E
T
-----------------------
S
------------------------
Q
R
L
A
N
L
R
Q
R
V
E
Q
F
A
R
A
F
P
M
---
82
PsiBlast_CBE
77.65
41%
-76
- C1 -
4PVF
3
GLYM_HUMAN
A:
[28-477]
---------------
L
S
D
S
D
P
E
M
W
E
L
L
Q
R
E
K
D
R
Q
C
R
G
L
E
L
I
A
S
E
N
F
C
S
R
A
A
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
K
R
Y
Y
G
G
A
E
V
V
D
E
I
E
L
L
C
Q
R
R
A
L
E
A
F
D
L
D
----
P
AQ
W
G
V
N
V
Q
P
Y
S
G
S
P
A
N
L
A
V
Y
T
A
L
L
Q
P
H
D
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
Y
M
S
DV
K
R
-------
I
S
A
T
S
I
F
F
E
S
M
P
Y
K
--
L
N
P
K
T
G
L
I
D
Y
N
Q
L
A
L
T
A
R
L
F
R
P
R
L
I
I
A
G
T
S
A
Y
A
R
L
I
D
Y
A
R
M
R
E
V
C
D
E
V
K
A
H
L
L
A
D
M
A
H
I
S
G
L
V
A
A
K
V
I
P
S
P
F
K
H
A
D
I
V
T
T
T
T
H
K
T
L
R
G
A
R
S
G
L
I
F
Y
-
R
---
K
GVKAIPY--------
T
--------
F
E
D
R
---------------
I
N
F
A
V
F
P
S
L
Q
G
G
P
-
H
N
H
A
I
A
A
V
A
V
A
L
K
Q
A
C
T
P
M
F
R
E
Y
S
L
Q
V
L
K
N
A
R
A
M
A
D
A
L
-
L
E
R
G
Y
S
L
V
S
G
G
T
D
N
H
L
V
L
V
D
L
R
P
K
-
G
L
D
G
A
R
A
E
R
V
L
E
L
V
S
I
T
A
N
K
N
T
C
P
G
D
R
S
A
-
I
T
P
G
G
L
R
L
G
A
P
A
L
T
S
R
Q
F
R
E
D
D
F
R
R
V
V
D
F
----
I
D
E
G
V
N
I
G
L
E
V
K
S
K
TA
K
L
Q
D
F
K
S
F
L
L
K
D
S
E
T
-----------------------
S
------------------------
Q
R
L
A
N
L
R
Q
R
V
E
Q
F
A
R
A
F
P
M
---
111
HHSearch
76.68
46%
-72
- C1 -
1RV3
4
GLYC_RABIT
A:
[23-478]
-------------
Q
P
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
L
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
----
P
QC
W
G
V
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
-----
F
M
T
DKKKIS
A
T
S
I
F
--
F
E
S
M
A
Y
K
--
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
-
R
---
R
---------------
G
VRSEILYN
L
E
S
L
---------------
I
N
S
A
V
F
P
G
L
Q
G
G
P
-
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
G
-
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
-
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
----
I
---------------------
H
R
G
I
E
L
T
V
Q
-----------------------
I
Q
D
D
T
GPRAT
L
K
E
F
K
E
K
L
A
G
DEKHQ
R
A
V
R
A
L
R
Q
E
V
E
S
F
A
A
L
F
P
L
P
--
83
PsiBlast_CBE
76.00
45%
-72
- C1 -
1BJ4
1
GLYC_HUMAN
A:
[16-443]
---------------
L
K
D
S
D
V
E
V
Y
N
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
Q
R
Y
Y
G
G
T
E
F
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
K
L
D
----
P
QC
W
G
V
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-------
I
S
A
T
S
I
F
F
E
S
M
P
Y
K
--
V
N
P
D
T
G
Y
I
N
Y
D
Q
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
E
Y
A
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
A
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
-
R
---
K
---------------
G
--------
V
K
S
V
DPATG
K
E
I
L
Y
N
L
E
S
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
-
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
L
E
F
K
V
Y
Q
H
Q
V
V
A
N
C
R
A
L
S
E
A
L
-
T
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
-
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
R
S
A
-
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
I
H
R
G
I
---------------------
E
L
T
L
Q
I
Q
S
D
-----------------------
T
GVA---------------------
A
T
L
K
E
F
K
E
R
L
A
-----------
93
PsiBlast_CBE
75.64
46%
-76
- C1 -
1RV4
4
GLYC_RABIT
B:
[25-424]
---------------
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
L
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
----
P
QC
W
G
V
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-------
I
S
A
T
S
I
F
F
E
S
M
A
Y
K
--
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
-
R
---
R
G
VRSVDK
E
I
L
Y
----
N
--------
L
E
S
L
---------------
I
N
S
A
V
F
P
G
L
Q
G
G
P
-
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
-
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
S
A
-
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
----
I
----------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
75.52
46%
-75
- C1 -
1RVU
3
GLYC_RABIT
B:
[25-424]
---------------
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
Q
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
----
P
QC
W
G
V
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-------
I
S
A
T
S
I
F
F
E
S
M
A
Y
K
--
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
-
R
---
R
G
VRSVDK
E
I
L
Y
----
N
--------
L
E
S
L
---------------
I
N
S
A
V
F
P
G
L
Q
G
G
P
-
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
-
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
S
A
-
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
----
I
----------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
75.18
46%
-74
- C1 -
1RVY
3
GLYC_RABIT
B:
[25-424]
---------------
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
Q
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
----
P
QC
W
G
V
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-------
I
S
A
T
S
I
F
F
E
S
M
A
Y
K
--
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
-
R
---
R
G
VRSVDK
E
I
L
Y
----
N
--------
L
E
S
L
---------------
I
N
S
A
V
F
P
G
L
Q
G
G
P
-
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
-
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
S
A
-
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
----
I
----------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
75.02
46%
-77
- C1 -
1CJ0
2
GLYC_RABIT
B:
[12-411]
---------------
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
----
P
QC
W
G
V
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-------
I
S
A
T
S
I
F
F
E
S
M
A
Y
K
--
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
-
R
---
R
G
V
RSVDK
E
I
L
Y
----
N
--------
L
E
S
L
---------------
I
N
S
A
V
F
P
G
L
Q
G
G
P
-
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
-
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
S
A
-
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
----
I
----------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
74.60
46%
-75
- C1 -
1RV3
4
GLYC_RABIT
B:
[25-424]
---------------
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
L
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
----
P
QC
W
G
V
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-------
I
S
A
T
S
I
F
F
E
S
M
A
Y
K
--
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
-
R
---
R
G
VRSVDK
E
I
L
Y
----
N
--------
L
E
S
L
---------------
I
N
S
A
V
F
P
G
L
Q
G
G
P
-
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
-
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
S
A
-
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
----
I
----------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
74.32
46%
-76
- C1 -
1RVY
3
GLYC_RABIT
A:
[25-424]
---------------
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
Q
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
----
P
QC
W
G
V
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-------
I
S
A
T
S
I
F
F
E
S
M
A
Y
K
--
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
-
R
---
R
G
VRSEILY-------
N
--------
L
E
S
L
---------------
I
N
S
A
V
F
P
G
L
Q
G
G
P
-
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
-
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
S
A
-
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
----
I
----------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
73.92
46%
-75
- C1 -
1RVU
3
GLYC_RABIT
A:
[25-424]
---------------
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
Q
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
----
P
QC
W
G
V
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-------
I
S
A
T
S
I
F
F
E
S
M
A
Y
K
--
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
-
R
---
R
G
VRSEILY-------
N
--------
L
E
S
L
---------------
I
N
S
A
V
F
P
G
L
Q
G
G
P
-
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
-
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
S
A
-
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
----
I
----------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
73.63
46%
-75
- C1 -
1RV4
4
GLYC_RABIT
A:
[25-424]
---------------
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
L
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
----
P
QC
W
G
V
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-------
I
S
A
T
S
I
F
F
E
S
M
A
Y
K
--
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
-
R
---
R
G
VRSEILY-------
N
--------
L
E
S
L
---------------
I
N
S
A
V
F
P
G
L
Q
G
G
P
-
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
-
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
S
A
-
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
----
I
----------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
73.54
46%
-74
- C1 -
1RV3
4
GLYC_RABIT
A:
[25-424]
---------------
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
L
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
----
P
QC
W
G
V
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-------
I
S
A
T
S
I
F
F
E
S
M
A
Y
K
--
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
-
R
---
R
G
VRSEILY-------
N
--------
L
E
S
L
---------------
I
N
S
A
V
F
P
G
L
Q
G
G
P
-
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
-
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
S
A
-
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
----
I
----------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
73.46
46%
-76
- C1 -
1CJ0
2
GLYC_RABIT
A:
[12-411]
---------------
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
----
P
QC
W
G
V
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-------
I
S
A
T
S
I
F
F
E
S
M
A
Y
K
--
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
-
R
---
R
G
VRSVDILY------
N
--------
L
E
S
L
---------------
I
N
S
A
V
F
P
G
L
Q
G
G
P
-
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
-
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
S
A
-
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
----
I
----------------------------------------------------------------------------------------------------