@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1924: (2016-03-30 )
MRDYTKQYINGEWVESNSNETIEVINPATEEVIGKVAKGNKADVDKAVEAADDVYLEFRHTSVKERQALLDKIVKEYENRKDDIVQAITDELGAPLSLSERVHYQMGLNHFVAARDALDNYEFEERRGDDLVVKEAIGVSGLITPWNFPTNQTSLKLAAAFAAGSPVVLKPSEETPFAAVILAEIFDKVGVPKGVFNLVNGDGAGVGNPLSEHPKVRMMSFTGSGPTGSKIMEKAAKDFKKVSLELGGKSPYIVLDDVDIKEAAKATTGKVVNNTGQVCTAGTRVLVPNKIKDAFLAELKEQFSQVRVGNPREDGTQVGPIISKKQFDQVQNYINKGIEEGAELFYGGPGKPEGLEKGYFARPTIFINVDNQMTIAQEEIFGPVMSVITYNDLDEAIQIANDTKYGLAGYVIGKDKETLHKVARSIEAGTVEINEAGRKPDLPFGGYKQSGLGREWGDYGIEEFLEVKSIAGYFK
Atome Classification :
(20 SA)
.........10........20........30........40........50.....---.--..60........70........80........90........100.....---..110.......120..----.-----.--...130....--------------.....140.......150.......160.......170.......180.......190.......200.......210.......220.......230...-....240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350..-.....360.......370.......380.......390.......400.......410.......420.......430....-.-..440........450.......460.......470...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MR
D
Y
T
K
Q
YIN
G
E
W
VESNSN
E
T
I
E
V
INP
A
T
E
E
V
I
G
K
VAKGN
K
A
D
V
D
K
A
V
E
AAD
D
V
Y
L
---
E
--
F
RHT
S
V
K
E
R
Q
A
L
L
D
K
I
V
K
E
Y
EN
R
K
D
D
I
V
Q
A
I
T
D
ELGAPL
S
L
S
E
R
V
H
Y
Q
MG---
L
N
H
F
V
A
A
R
D
ALDNY
E
F
E
----E-----R--RGD
D
--
L
V
V
K
--------------
E
AIGVSGLITPWNFPTNQ
T
S
L
K
L
A
A
A
FAAGS
P
V
V
L
KPSEET
P
F
A
A
V
I
L
A
E
I
F
D
KVGVP
K
G
V
F
N
LVNGDGAGVGNPLSEHP
K
V
R
M
M
S
F
TGSGP
T
G
S
K
I
M
E
K
A
-
A
K
D
F
K
K
V
S
L
E
LGGKS
P
Y
I
V
L
DDV
D
I
K
E
A
AKATTG
K
V
VNNTG
Q
V
CTAG
T
R
V
LVP
N
K
I
K
D
A
F
L
A
E
L
K
E
Q
F
S
QVRVGNPREDGTQVGPI
I
S
K
K
Q
F
D
Q
V
Q
N
Y
I
N
K
G
I
E
EGA
E
L
F
YGGPGKPEG-LEKGYFAR
P
T
I
F
I
NVDN
Q
M
T
I
A
Q
E
E
I
F
G
P
V
M
S
V
I
T
Y
N
D
L
D
E
A
I
Q
IANDTKYG
L
A
G
Y
V
IGK
D
K
E
T
L
H
K
V
A
R
SIEA
G
T
V
E
INEA-G-RKP-DLPFGGYKQSGLGR
E
W
G
D
Y
G
I
E
E
F
L
E
V
K
S
I
AGYFK
125
HHSearch
99.34
100%
-80
- C4 -
3TY7
4
ALD1_STAAM
A:
[4-477]
M
R
D
Y
T
K
Q
Y
I
N
G
E
W
V
E
S
N
S
N
E
T
I
E
V
I
N
P
A
T
E
E
V
I
G
K
V
A
K
G
N
K
A
D
V
D
K
A
V
E
A
A
D
D
V
Y
L
---
E
--
F
R
H
T
S
V
K
E
R
Q
A
L
L
D
K
I
V
K
E
Y
E
N
R
K
D
D
I
V
Q
A
I
T
D
E
L
G
A
P
L
S
L
S
E
R
V
H
Y
Q
M
G
---
L
N
H
F
V
A
A
R
D
A
L
D
N
Y
E
F
E
----
E
-----
R
--
R
G
D
D
--
L
V
V
K
--------------
E
A
I
G
V
S
G
L
I
T
P
W
N
F
P
T
N
Q
T
S
L
K
L
A
A
A
F
A
A
G
S
P
V
V
L
K
P
S
E
E
T
P
F
A
A
V
I
L
A
E
I
F
D
K
V
G
V
P
K
G
V
F
N
L
V
N
G
D
G
A
G
V
G
N
P
L
S
E
H
P
K
V
R
M
M
S
F
T
G
S
G
P
T
G
S
--
M
E
K
A
-
A
K
D
F
K
K
V
S
L
E
L
G
G
K
S
P
Y
I
V
L
D
D
V
D
I
K
E
A
A
K
A
T
T
G
K
V
V
N
N
T
G
Q
V
C
T
A
G
T
R
V
L
V
P
N
K
I
K
D
A
F
L
A
E
L
K
E
Q
F
S
Q
V
R
V
G
N
P
R
E
D
G
T
Q
V
G
P
I
I
S
K
K
Q
F
D
Q
V
Q
N
Y
I
N
K
G
I
E
E
G
A
E
L
F
Y
G
G
P
G
K
P
E
G
-
L
E
K
G
Y
F
A
R
P
T
I
F
I
N
V
D
N
Q
M
T
I
A
Q
E
E
I
F
G
P
V
M
S
V
I
T
Y
N
D
L
D
E
A
I
Q
I
A
N
D
T
K
Y
G
L
A
G
Y
V
I
G
K
D
K
E
T
L
H
K
V
A
R
S
I
E
A
G
T
V
E
I
N
E
A
-
G
------------------------
G
I
E
E
F
L
E
V
K
S
I
A
G
Y
F
-
1
PsiBlast_PDB
98.66
98%
-79
- C4 -
3TY7
4
ALD1_STAAM
A:
[5-478]
-
R
D
Y
T
K
Q
Y
I
N
G
E
W
V
E
S
N
S
N
E
T
I
E
V
I
N
P
A
T
E
E
V
I
G
K
V
A
K
G
N
K
A
D
V
D
K
A
V
E
A
A
D
D
V
Y
L
---
E
--
F
R
H
T
S
V
K
E
R
Q
A
L
L
D
K
I
V
K
E
Y
E
N
R
K
D
D
I
V
Q
A
I
T
D
E
L
G
A
P
L
S
L
S
E
R
V
H
Y
Q
M
G
---
L
N
H
F
V
A
A
R
D
A
L
D
N
Y
E
F
E
----
E
-----
R
--
R
G
D
D
--
L
V
V
K
--------------
E
A
I
G
V
S
G
L
I
T
P
W
N
F
P
T
N
Q
T
S
L
K
L
A
A
A
F
A
A
G
S
P
V
V
L
K
P
S
E
E
T
P
F
A
A
V
I
L
A
E
I
F
D
K
V
G
V
P
K
G
V
F
N
L
V
N
G
D
G
A
G
V
G
N
P
L
S
E
H
P
K
V
R
M
M
S
F
T
G
S
G
P
T
G
S
--
M
E
K
A
-
A
K
D
F
K
K
V
S
L
E
L
G
G
K
S
P
Y
I
V
L
D
D
V
D
I
K
E
A
A
K
A
T
T
G
K
V
V
N
N
T
G
Q
V
C
T
A
G
T
R
V
L
V
P
N
K
I
K
D
A
F
L
A
E
L
K
E
Q
F
S
Q
V
R
V
G
N
P
R
E
D
G
T
Q
V
G
P
I
I
S
K
K
Q
F
D
Q
V
Q
N
Y
I
N
K
G
I
E
E
G
A
E
L
F
Y
G
G
P
G
K
P
E
G
-
L
E
K
G
Y
F
A
R
P
T
I
F
I
N
V
D
N
Q
M
T
I
A
Q
E
E
I
F
G
P
V
M
S
V
I
T
Y
N
D
L
D
E
A
I
Q
I
A
N
D
T
K
Y
G
L
A
G
Y
V
I
G
K
D
K
E
T
L
H
K
V
A
R
S
I
E
A
G
T
V
E
I
N
E
A
-
G
------------------------
G
I
E
E
F
L
E
V
K
S
I
A
G
Y
F
K
2
PsiBlast_PDB
81.43
41%
-60
- C4 -
3I44
3
?
A:
[22-497]
M
L
N
K
R
K
F
Y
I
N
G
L
W
D
D
P
S
T
P
H
D
L
Y
V
I
D
P
S
T
E
E
A
C
A
V
I
S
L
G
S
T
R
D
A
D
K
A
I
N
A
A
K
K
A
F
Q
---
T
--
W
K
T
T
S
P
H
E
R
L
G
F
V
E
K
I
L
E
I
Y
E
K
R
S
S
D
M
A
K
T
I
S
M
E
M
G
A
P
I
D
M
A
L
N
A
Q
T
A
T
G
---
S
S
H
I
R
N
F
I
K
A
Y
K
E
F
S
F
Q
----
E
-----
A
LI
E
G
N
E
Q
A
I
L
H
Y
--------------
D
A
I
G
V
V
G
L
I
T
P
W
N
W
P
M
N
Q
V
T
L
K
V
I
P
A
L
L
A
G
C
T
M
V
L
K
P
S
E
I
A
P
L
S
A
M
L
F
A
E
I
L
D
E
A
A
L
P
S
G
V
F
N
L
I
N
G
D
G
A
N
V
G
S
Y
L
S
A
H
P
D
L
E
M
I
S
F
T
G
S
T
R
A
G
K
D
I
S
K
N
A
-
S
N
T
L
K
R
V
C
L
E
L
G
G
K
G
A
N
I
I
F
A
D
A
D
I
-
D
A
L
Q
R
G
V
R
H
C
F
Y
N
S
G
Q
S
C
N
A
P
T
R
M
L
V
E
Q
A
I
Y
D
K
A
I
K
T
A
K
D
I
A
E
K
T
Q
V
G
P
G
H
Q
T
G
N
H
I
G
P
V
V
S
K
E
Q
Y
D
K
I
Q
D
L
I
Q
S
G
I
D
E
G
A
T
L
V
T
G
G
T
G
L
P
M
G
-
M
E
R
G
Y
Y
V
R
P
T
V
F
A
D
V
K
P
H
M
R
I
F
R
E
E
I
F
G
P
V
L
S
L
L
P
F
N
T
E
D
E
A
V
T
L
A
N
D
T
E
Y
G
L
T
N
Y
I
Q
S
Q
D
R
S
K
C
R
R
I
A
A
Q
V
R
S
G
M
V
E
V
N
G
H
-
E
-
L
P
G
-
G
S
Y
F
G
G
V
K
F
S
G
R
A
R
E
G
G
L
W
G
I
K
E
F
L
D
T
K
A
I
S
Y
W
--
116
HHSearch
79.57
41%
-58
- C4 -
3I44
3
?
A:
[22-496]
M
L
N
K
R
K
F
Y
I
N
G
L
W
D
D
P
S
T
P
H
D
L
Y
V
I
D
P
S
T
E
E
A
C
A
V
I
S
L
G
S
T
R
D
A
D
K
A
I
N
A
A
K
K
A
F
Q
---
T
--
W
K
T
T
S
P
H
E
R
L
G
F
V
E
K
I
L
E
I
Y
E
K
R
S
S
D
M
A
K
T
I
S
M
E
M
G
A
P
I
D
M
A
L
N
A
Q
T
A
T
G
---
S
S
H
I
R
N
F
I
K
A
Y
K
E
F
S
F
Q
EALI
E
-----
G
--
N
E
Q
A
--
I
L
H
Y
--------------
D
A
I
G
V
V
G
L
I
T
P
W
N
W
P
M
N
Q
V
T
L
K
V
I
P
A
L
L
A
G
C
T
M
V
L
K
P
S
E
I
A
P
L
S
A
M
L
F
A
E
I
L
D
E
A
A
L
P
S
G
V
F
N
L
I
N
G
D
G
A
N
V
G
S
Y
L
S
A
H
P
D
L
E
M
I
S
F
T
G
S
T
R
A
G
K
D
I
S
K
N
A
-
S
N
T
L
K
R
V
C
L
E
L
G
G
K
G
A
N
I
I
F
A
D
A
D
I
D
A
L
Q
-
R
G
V
R
H
C
F
Y
N
S
G
Q
S
C
N
A
P
T
R
M
L
V
E
Q
A
I
Y
D
K
A
I
K
T
A
K
D
I
A
E
K
T
Q
V
G
P
G
H
Q
T
G
N
H
I
G
P
V
V
S
K
E
Q
Y
D
K
I
Q
D
L
I
Q
S
G
I
D
E
G
A
T
L
V
T
G
G
T
G
L
P
M
G
-
M
E
R
G
Y
Y
V
R
P
T
V
F
A
D
V
K
P
H
M
R
I
F
R
E
E
I
F
G
P
V
L
S
L
L
P
F
N
T
E
D
E
A
V
T
L
A
N
D
T
E
Y
G
L
T
N
Y
I
Q
S
Q
D
R
S
K
C
R
R
I
A
A
Q
V
R
S
G
M
V
E
V
N
G
H
-
E
-
L
P
G
-
G
S
Y
F
G
G
V
K
F
S
G
R
A
R
E
G
G
L
W
G
I
K
E
F
L
D
T
K
A
I
S
Y
---
136
HHSearch
78.48
37%
-56
- C4 -
1O04
2
ALDH2_HUMAN
A:
[17-496]
-
V
F
C
N
Q
I
F
I
N
N
E
W
H
D
A
V
S
R
K
T
F
P
T
V
N
P
S
T
G
E
V
I
C
Q
V
A
E
G
D
K
E
D
V
D
K
A
V
K
A
A
R
A
A
F
Q
LGS
P
--
W
R
R
M
D
A
S
H
R
G
R
L
L
N
R
L
A
D
L
I
E
R
D
R
T
Y
L
A
A
L
E
T
L
D
N
G
K
P
Y
V
I
S
Y
L
V
D
L
D
M
V
---
L
K
C
L
R
Y
Y
A
G
W
A
D
K
Y
H
G
K
----
T
I
PID-
G
--
D
F
F
S
--
Y
T
R
H
--------------
E
P
V
G
V
C
G
Q
I
I
P
W
N
F
P
L
L
M
Q
A
W
K
L
G
P
A
L
A
T
G
N
V
V
V
M
K
V
A
E
Q
T
P
L
T
A
L
Y
V
A
N
L
I
K
E
A
G
F
P
P
G
V
V
N
I
V
P
G
F
G
P
T
A
G
A
A
I
A
S
H
E
D
V
D
K
V
A
F
T
G
S
T
E
I
G
R
V
I
Q
V
A
A
G
S
S
N
L
K
R
V
T
L
E
L
G
G
K
S
P
N
I
I
M
S
D
A
D
M
D
W
A
V
E
Q
A
H
F
A
L
F
F
N
Q
G
Q
C
S
C
A
G
S
R
T
F
V
Q
E
D
I
Y
D
E
F
V
E
R
S
V
A
R
A
K
S
R
V
V
G
N
P
F
D
S
K
T
E
Q
G
P
Q
V
D
E
T
Q
F
K
K
I
L
G
Y
I
N
T
G
K
Q
E
G
A
K
L
L
C
G
G
G
I
A
----
A
D
R
G
Y
F
I
Q
P
T
V
F
G
D
V
Q
D
G
M
T
I
A
K
E
E
I
F
G
P
V
M
Q
I
L
K
F
K
T
I
E
E
V
V
G
R
A
N
N
S
T
Y
G
L
A
A
A
V
F
T
K
D
L
D
K
A
N
Y
L
S
Q
A
L
Q
A
G
T
V
W
V
N
C
Y
D
V
-
F
G
A
-
Q
S
P
F
G
G
Y
K
M
S
G
S
G
R
E
L
G
E
Y
G
L
Q
A
Y
T
E
V
K
T
V
T
V
K
V
P
33
PsiBlast_CBE
78.45
38%
-61
- C4 -
4CBB
30
BETB_PSEAE
H:
[7-478]
-----
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
---
V
--
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
ADV
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
----
L
-----
R
--
E
T
S
F
--
V
Y
T
R
R-------------
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
-
G
-
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
-----
28
PsiBlast_CBE
78.27
38%
-60
- C4 -
2WME
21
BETB_PSEAE
H:
[8-479]
-----
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
---
V
--
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
ADV
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
----
L
-----
R
--
E
T
S
F
--
V
Y
T
R
R-------------
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
-
G
-
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
-----
49
PsiBlast_CBE
78.17
37%
-55
- C4 -
4PT0
2
?
D:
[16-489]
L
N
E
E
I
K
M
F
I
N
G
E
F
V
S
A
I
G
G
K
T
F
E
T
Y
N
P
A
T
E
D
V
L
A
V
V
C
E
A
Q
E
E
D
I
D
A
A
V
K
A
A
R
S
A
F
E
---
S
GP
W
A
E
M
T
T
A
E
R
A
H
L
I
Y
K
L
A
D
L
I
E
E
H
R
E
E
L
A
Q
L
E
A
L
D
N
G
K
P
--------
Y
Q
V
A
---
L
D
D
D
I
S
A
--
T
V
E
N
Y
R
Y
Y
----
A
-----
G
--
W
T
T
K
--
I
I
G
Q
TIPISKDYLNYTRH
E
P
V
G
V
V
G
Q
I
I
P
W
N
F
P
L
V
M
S
S
W
K
M
G
A
A
L
A
T
G
C
T
I
V
L
K
P
A
E
Q
T
P
L
S
L
L
Y
A
A
K
L
F
K
E
A
G
F
P
N
G
V
V
N
F
V
P
G
F
G
P
E
A
G
A
A
I
V
N
H
H
D
I
D
K
V
A
F
T
G
S
T
V
T
G
K
Y
I
M
R
Q
S
-
A
E
M
I
K
H
V
T
L
E
L
G
G
K
S
P
N
I
I
L
E
D
A
D
L
E
E
A
I
N
G
A
F
Q
G
I
M
Y
N
H
G
Q
N
C
S
A
G
S
R
V
F
V
H
R
K
H
Y
E
T
V
V
D
A
L
V
K
M
A
N
N
V
K
L
G
A
G
M
E
K
E
T
E
M
G
P
L
V
S
K
K
Q
Q
E
R
V
L
N
Y
I
E
Q
G
K
K
E
G
A
T
V
A
A
G
G
---
E
R
A
-
L
E
K
G
Y
F
V
K
P
T
V
F
T
D
V
T
D
D
M
T
I
V
K
E
E
I
F
G
P
V
V
V
V
L
P
F
D
S
T
E
E
V
I
E
R
A
N
N
S
S
Y
G
L
A
A
G
V
W
T
Q
N
I
K
T
G
H
Q
V
A
N
K
L
K
A
G
T
V
W
I
N
D
Y
-
N
L
E
N
A
-
A
A
P
F
G
G
Y
K
Q
S
G
I
G
R
E
L
G
S
Y
A
L
D
N
Y
T
E
V
K
S
V
-----
85
PsiBlast_CBE
78.03
38%
-58
- C4 -
2WME
1
BETB_PSEAE
C:
[8-479]
-----
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
---
V
--
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
ADV
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
----
L
-----
R
--
E
T
S
F
--
V
Y
T
R
R-------------
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
-
G
-
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
-----
41
PsiBlast_CBE
77.98
38%
-60
- C4 -
2WOX
5
BETB_PSEAE
C:
[7-478]
-----
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
---
V
--
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
ADV
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
----
L
-----
R
--
E
T
S
F
--
V
Y
T
R
R-------------
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
-
G
-
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
-----
45
PsiBlast_CBE
77.91
38%
-62
- C4 -
2XDR
8
BETB_PSEAE
B:
[7-478]
-----
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
---
V
--
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
ADV
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
----
L
-----
R
--
E
T
S
F
--
V
Y
T
R
R-------------
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
A
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
-
G
-
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
-----
53
PsiBlast_CBE
77.88
37%
-58
- C4 -
4PS9
1
?
C:
[16-489]
L
N
E
E
I
K
M
F
I
N
G
E
F
V
S
A
I
G
G
K
T
F
E
T
Y
N
P
A
T
E
D
V
L
A
V
V
C
E
A
Q
E
E
D
I
D
A
A
V
K
A
A
R
S
A
F
E
---
S
GP
W
A
E
M
T
T
A
E
R
A
H
L
I
Y
K
L
A
D
L
I
E
E
H
R
E
E
L
A
Q
L
E
A
L
D
N
G
K
P
--------
Y
Q
V
A
---
L
D
D
D
I
S
A
--
T
V
E
N
Y
R
Y
Y
----
A
-----
G
--
W
T
T
K
--
I
I
G
Q
T
I
PISKD
Y
L
N
Y
T
R
H
E
P
V
G
V
V
G
Q
I
I
P
W
N
F
P
L
V
M
S
S
W
K
M
G
A
A
L
A
T
G
C
T
I
V
L
K
P
A
E
Q
T
P
L
S
L
L
Y
A
A
K
L
F
K
E
A
G
F
P
N
G
V
V
N
F
V
P
G
F
G
P
E
A
G
A
A
I
V
N
H
H
D
I
D
K
V
A
F
T
G
S
T
V
T
G
K
Y
I
M
R
Q
S
-
A
E
M
I
K
H
V
T
L
E
L
G
G
K
S
P
N
I
I
L
E
D
A
D
L
E
E
A
I
N
G
A
F
Q
G
I
M
Y
N
H
G
Q
N
C
S
A
G
S
R
V
F
V
H
R
K
H
Y
E
T
V
V
D
A
L
V
K
M
A
N
N
V
K
L
G
A
G
M
E
K
E
T
E
M
G
P
L
V
S
K
K
Q
Q
E
R
V
L
N
Y
I
E
Q
G
K
K
E
G
A
T
V
A
A
G
G
---
E
R
A
-
L
E
K
G
Y
F
V
K
P
T
V
F
T
D
V
T
D
D
M
T
I
V
K
E
E
I
F
G
P
V
V
V
V
L
P
F
D
S
T
E
E
V
I
E
R
A
N
N
S
S
Y
G
L
A
A
G
V
W
T
Q
N
I
K
T
G
H
Q
V
A
N
K
L
K
A
G
T
V
W
I
N
D
Y
-
N
L
E
N
A
-
A
A
P
F
G
G
Y
K
Q
S
G
I
G
R
E
L
G
S
Y
A
L
D
N
Y
T
E
V
K
S
V
-----
38
PsiBlast_CBE
77.80
38%
-60
- C4 -
4CBB
1
BETB_PSEAE
C:
[7-478]
-----
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
---
V
--
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
ADV
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
----
L
-----
R
--
E
T
S
F
--
V
Y
T
R
R-------------
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
-
G
-
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
-----
12
PsiBlast_PDB
77.78
37%
-57
- C4 -
4PT0
2
?
A:
[16-489]
L
N
E
E
I
K
M
F
I
N
G
E
F
V
S
A
I
G
G
K
T
F
E
T
Y
N
P
A
T
E
D
V
L
A
V
V
C
E
A
Q
E
E
D
I
D
A
A
V
K
A
A
R
S
A
F
E
---
S
GP
W
A
E
M
T
T
A
E
R
A
H
L
I
Y
K
L
A
D
L
I
E
E
H
R
E
E
L
A
Q
L
E
A
L
D
N
G
K
P
--------
Y
Q
V
A
---
L
D
D
D
I
S
A
--
T
V
E
N
Y
R
Y
Y
----
A
-----
G
--
W
T
T
K
--
I
I
G
Q
T
I
PISKDYL
N
Y
T
R
H
E
P
V
G
V
V
G
Q
I
I
P
W
N
F
P
L
V
M
S
S
W
K
M
G
A
A
L
A
T
G
C
T
I
V
L
K
P
A
E
Q
T
P
L
S
L
L
Y
A
A
K
L
F
K
E
A
G
F
P
N
G
V
V
N
F
V
P
G
F
G
P
E
A
G
A
A
I
V
N
H
H
D
I
D
K
V
A
F
T
G
S
T
V
T
G
K
Y
I
M
R
Q
S
-
A
E
M
I
K
H
V
T
L
E
L
G
G
K
S
P
N
I
I
L
E
D
A
D
L
E
E
A
I
N
G
A
F
Q
G
I
M
Y
N
H
G
Q
N
C
S
A
G
S
R
V
F
V
H
R
K
H
Y
E
T
V
V
D
A
L
V
K
M
A
N
N
V
K
L
G
A
G
M
E
K
E
T
E
M
G
P
L
V
S
K
K
Q
Q
E
R
V
L
N
Y
I
E
Q
G
K
K
E
G
A
T
V
A
A
G
G
---
E
R
A
-
L
E
K
G
Y
F
V
K
P
T
V
F
T
D
V
T
D
D
M
T
I
V
K
E
E
I
F
G
P
V
V
V
V
L
P
F
D
S
T
E
E
V
I
E
R
A
N
N
S
S
Y
G
L
A
A
G
V
W
T
Q
N
I
K
T
G
H
Q
V
A
N
K
L
K
A
G
T
V
W
I
N
D
Y
-
N
L
E
N
A
-
A
A
P
F
G
G
Y
K
Q
S
G
I
G
R
E
L
G
S
Y
A
L
D
N
Y
T
E
V
K
S
V
-----
130
HHSearch
77.76
36%
-56
- C4 -
3JZ4
1
GABD_ECOLI
A:
[6-481]
N
L
F
R
Q
Q
A
L
I
N
G
E
W
L
D
A
N
N
G
E
A
I
D
V
T
N
P
A
N
G
D
K
L
G
S
V
P
K
M
G
A
D
E
T
R
A
A
I
D
A
A
N
R
A
L
P
---
A
--
W
R
A
L
T
A
K
E
R
A
T
I
L
R
N
W
F
N
L
M
M
E
H
Q
D
D
L
A
R
L
M
T
L
E
Q
G
K
P
L
A
E
A
K
-
G
E
I
S
Y
A
---
A
S
F
I
E
W
F
A
E
E
G
K
R
I
Y
G
D
----
T
I
PGHQ
A
--
D
K
R
L
--
I
V
I
K
--------------
Q
P
I
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
G
P
A
L
A
A
G
C
T
M
V
L
K
P
A
S
Q
T
P
F
S
A
L
A
L
A
E
L
A
I
R
A
G
V
P
A
G
V
F
N
V
V
T
G
S
A
G
A
V
G
N
E
L
T
S
N
P
L
V
R
K
L
S
F
T
G
S
T
E
I
G
R
Q
L
M
E
Q
C
-
A
K
D
I
K
K
V
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
K
A
V
E
G
A
L
A
S
K
F
R
N
A
G
Q
T
C
V
C
A
N
R
L
Y
V
Q
D
G
V
Y
D
R
F
A
E
K
L
Q
Q
A
M
S
K
L
H
I
G
D
G
L
D
N
G
V
T
I
G
P
L
I
D
E
K
A
V
A
K
V
E
E
H
I
A
D
A
L
E
K
G
A
R
V
V
C
G
G
K
A
H
----
E
R
G
G
N
F
F
Q
P
T
I
L
V
D
V
P
A
N
A
K
V
S
K
E
E
T
F
G
P
L
A
P
L
F
R
F
K
D
E
A
D
V
I
A
Q
A
N
D
T
E
F
G
L
A
A
Y
F
Y
A
R
D
L
S
R
V
F
R
V
G
E
A
L
E
Y
G
I
V
G
I
N
T
G
I
I
-
S
N
E
-
V
A
P
F
G
G
I
K
A
S
G
L
G
R
E
G
S
K
Y
G
I
E
D
Y
L
E
I
K
Y
M
C
I
G
L
-
48
PsiBlast_CBE
77.68
37%
-57
- C4 -
4PT3
4
?
B:
[16-489]
L
N
E
E
I
K
M
F
I
N
G
E
F
V
S
A
I
G
G
K
T
F
E
T
Y
N
P
A
T
E
D
V
L
A
V
V
C
E
A
Q
E
E
D
I
D
A
A
V
K
A
A
R
S
A
F
E
---
S
GP
W
A
E
M
T
T
A
E
R
A
H
L
I
Y
K
L
A
D
L
I
E
E
H
R
E
E
L
A
Q
L
E
A
L
D
N
G
K
P
--------
Y
Q
V
A
---
L
D
D
D
I
S
A
--
T
V
E
N
Y
R
Y
Y
----
A
-----
G
--
W
T
T
K
--
I
I
G
Q
T
I
PISKDYL
N
Y
T
R
H
E
P
V
G
V
V
G
Q
I
I
P
W
N
F
P
L
V
M
S
S
W
K
M
G
A
A
L
A
T
G
C
T
I
V
L
K
P
A
E
Q
T
P
L
S
L
L
Y
A
A
K
L
F
K
E
A
G
F
P
N
G
V
V
N
F
V
P
G
F
G
P
E
A
G
A
A
I
V
N
H
H
D
I
D
K
V
A
F
T
G
S
T
V
T
G
K
Y
I
M
R
Q
S
-
A
E
M
I
K
H
V
T
L
E
L
G
G
K
S
P
N
I
I
L
E
D
A
D
L
E
E
A
I
N
G
A
F
Q
G
I
M
Y
N
H
G
Q
N
C
S
A
G
S
R
V
F
V
H
R
K
H
Y
E
T
V
V
D
A
L
V
K
M
A
N
N
V
K
L
G
A
G
M
E
K
E
T
E
M
G
P
L
V
S
K
K
Q
Q
E
R
V
L
N
Y
I
E
Q
G
K
K
E
G
A
T
V
A
A
G
G
---
E
R
A
-
L
E
K
G
Y
F
V
K
P
T
V
F
T
D
V
T
D
D
M
T
I
V
K
E
E
I
F
G
P
V
V
V
V
L
P
F
D
S
T
E
E
V
I
E
R
A
N
N
S
S
Y
G
L
A
A
G
V
W
T
Q
N
I
K
T
G
H
Q
V
A
N
K
L
K
A
G
T
V
W
I
N
D
Y
-
N
L
E
N
A
-
A
A
P
F
G
G
Y
K
Q
S
G
I
G
R
E
L
G
S
Y
A
L
D
N
Y
T
E
V
K
S
V
-----
44
PsiBlast_CBE
77.68
38%
-60
- C4 -
2XDR
8
BETB_PSEAE
C:
[7-478]
-----
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
---
V
--
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
ADV
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
----
L
-----
R
--
E
T
S
F
--
V
Y
T
R
R-------------
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
A
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
-
G
-
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
-----
14
PsiBlast_PDB
77.48
38%
-59
- C4 -
3ZQA
13
BETB_PSEAE
A:
[8-479]
-----
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
---
V
--
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
----
L
-----
R
--
E
T
S
F
--
V
Y
T
R
R-------------
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
A
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
-
G
-
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
-----
43
PsiBlast_CBE
77.46
38%
-60
- C4 -
2XDR
6
BETB_PSEAE
D:
[7-478]
-----
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
---
V
--
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
ADV
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
----
L
-----
R
--
E
T
S
F
--
V
Y
T
R
R-------------
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
A
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
-
G
-
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
-----
46
PsiBlast_CBE
77.45
37%
-57
- C4 -
4PT3
3
?
D:
[16-489]
L
N
E
E
I
K
M
F
I
N
G
E
F
V
S
A
I
G
G
K
T
F
E
T
Y
N
P
A
T
E
D
V
L
A
V
V
C
E
A
Q
E
E
D
I
D
A
A
V
K
A
A
R
S
A
F
E
---
S
GP
W
A
E
M
T
T
A
E
R
A
H
L
I
Y
K
L
A
D
L
I
E
E
H
R
E
E
L
A
Q
L
E
A
L
D
N
G
K
P
--------
Y
Q
V
A
---
L
D
D
D
I
S
A
--
T
V
E
N
Y
R
Y
Y
----
A
-----
G
--
W
T
T
K
--
I
I
G
Q
TIPISKDYLNYTRH
E
P
V
G
V
V
G
Q
I
I
P
W
N
F
P
L
V
M
S
S
W
K
M
G
A
A
L
A
T
G
C
T
I
V
L
K
P
A
E
Q
T
P
L
S
L
L
Y
A
A
K
L
F
K
E
A
G
F
P
N
G
V
V
N
F
V
P
G
F
G
P
E
A
G
A
A
I
V
N
H
H
D
I
D
K
V
A
F
T
G
S
T
V
T
G
K
Y
I
M
R
Q
S
-
A
E
M
I
K
H
V
T
L
E
L
G
G
K
S
P
N
I
I
L
E
D
A
D
L
E
E
A
I
N
G
A
F
Q
G
I
M
Y
N
H
G
Q
N
C
S
A
G
S
R
V
F
V
H
R
K
H
Y
E
T
V
V
D
A
L
V
K
M
A
N
N
V
K
L
G
A
G
M
E
K
E
T
E
M
G
P
L
V
S
K
K
Q
Q
E
R
V
L
N
Y
I
E
Q
G
K
K
E
G
A
T
V
A
A
G
G
---
E
R
A
-
L
E
K
G
Y
F
V
K
P
T
V
F
T
D
V
T
D
D
M
T
I
V
K
E
E
I
F
G
P
V
V
V
V
L
P
F
D
S
T
E
E
V
I
E
R
A
N
N
S
S
Y
G
L
A
A
G
V
W
T
Q
N
I
K
T
G
H
Q
V
A
N
K
L
K
A
G
T
V
W
I
N
D
Y
-
N
L
E
N
A
-
A
A
P
F
G
G
Y
K
Q
S
G
I
G
R
E
L
G
S
Y
A
L
D
N
Y
T
E
V
K
S
V
-----