@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1938: (2016-03-30 )
MRMIDIIEKKRDGHTLTTEEINFFIDGYVKGDIPDYQASSLAMAIYFQDMNDDERAALTMAMVNSGDMIDLSDIKGVKVDKHSTGGVGDTTTLVLAPLVAAVDVPVAKMSGRGLGHTGGTIDKLEAIDGFHVEIDEATFVKLVNENKVAVVGQSGNLTPADKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGSGAFMKTLEDAEALAHAMVRIGNNVGRNTMAIISDMNQPLGRAIGNALELQEAIDTLKGQGPKDLTELVLTLGSQMVVLANKAETLEEARALLIEAINSGAALEKFKTFIKNQGGDETVIDHPERLPQAQYQIEYKAKKSGYVTELVSNDIGVASMMLGAGRLTKEDDIDLAVGIVLNKKIGDKVEEGESLLTIHSNRQDVDDVVKKLDSSITIADHVVSPTLIHKIITE
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70..-.--.....80........90........100.......110.......120.......130.......140.......150.......160.......170.....-..180.......190.......200.......210.......220.......230.......240.......250.......260.--......270.......280.......290.......300.......310.......-320-------.......---------..330.......340.......350.......360.......370.......380.......390.......400-.......410.......420........430.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
M
I
D
I
I
E
KKRDG
H
T
L
T
T
E
E
I
N
F
F
I
D
G
Y
VKGDIPDYQAS
S
L
A
M
A
I
Y
F
QDMNDD
E
R
A
A
L
T
M
A
MVNSG
D
M
I
D
LSD-I--K
G
V
K
VDKHSTGGVGD
T
T
T
L
V
L
A
P
L
V
A
A
VDVP
V
A
KMSGRGLGHTGGTI
D
K
L
EAID
G
F
H
V
EIDE
A
T
F
V
K
L
VNEN
K
V
A
V
VGQSGNLTPADK
K
L
Y
A
L
RDVTGTVN
S
I
-
P
L
I
A
S
S
I
M
S
K
K
IAAGA
D
A
I
V
L
D
VKTGS
G
A
F
M
K
T
L
E
D
A
E
A
L
A
H
A
M
V
R
IGNNVGR
N
T
M
A
I
I
S
DM
N
Q
P
L
G
R
A
I
G
N
A
L
E
L
Q
E
A
I
D
T
LKGQ--
G
P
K
D
L
T
E
L
V
L
T
LGS
Q
M
V
V
LAN
K
A
E
T
L
E
E
A
R
A
L
L
I
E
A
INSG
A
A
L
E
K
F
K
T
F
I
KNQGGD-E---------TVIDH
P
E
---------RLPQ
A
Q
Y
Q
I
E
Y
K
AKKSG
Y
V
T
E
L
V
SND
I
G
V
A
S
M
M
LGAGRLTKEDDI
D
L
A
V
G
I
V
LNKKIGD
K
V
EEG
E
S
L
L
T
IHSNRQ-
D
V
D
D
V
V
K
K
LDSS
I
T
I
A
D
H-VV
S
P
T
L
I
H
K
I
ITE
32
HHSearch
98.93
99%
-87
- C3 -
3H5Q
3
PDP_STAAC
A:
[4-436]
M
R
M
I
D
I
I
E
K
K
R
D
G
H
T
L
T
T
E
E
I
N
F
F
I
G
G
Y
V
K
G
D
I
P
D
Y
Q
A
S
S
L
A
M
A
I
Y
F
Q
D
M
N
D
D
E
R
V
A
L
T
M
A
M
V
N
S
G
D
M
I
D
L
S
D
-
I
--
K
G
V
K
V
D
K
H
S
T
G
G
V
G
D
T
T
T
L
V
L
A
P
L
V
A
A
V
D
V
P
V
A
K
M
S
G
R
G
L
G
H
T
G
G
T
I
D
K
L
E
A
I
D
G
F
H
V
E
I
D
E
A
T
F
V
K
L
V
N
E
N
K
V
A
V
V
G
Q
S
G
N
L
T
P
A
D
K
K
L
Y
A
L
R
D
V
T
G
T
V
-
N
S
I
P
L
I
A
S
S
I
M
S
K
K
I
A
A
G
A
D
A
I
V
L
D
V
K
T
G
S
G
A
F
M
K
T
L
E
D
A
E
A
L
A
H
A
M
V
R
I
G
N
N
V
G
R
N
T
M
A
I
I
S
D
M
N
Q
P
L
G
R
A
I
G
N
A
L
E
L
Q
E
A
I
D
T
L
K
G
Q
--
G
P
K
D
L
T
E
L
V
L
T
L
G
S
Q
M
V
V
L
A
N
K
A
E
T
L
E
E
A
R
A
L
L
I
E
A
I
N
S
G
A
A
L
E
K
F
K
T
F
I
K
N
Q
G
G
D
-
E
---------
T
V
I
D
H
P
E
---------
R
L
P
Q
A
Q
Y
Q
I
E
Y
K
A
K
K
S
G
Y
V
T
E
L
V
S
N
D
I
G
V
A
S
M
M
L
G
A
G
R
L
T
K
E
D
D
I
D
L
A
V
G
I
V
L
N
K
K
I
G
D
K
V
E
E
G
E
S
L
L
T
I
H
S
N
R
Q
D
V
D
D
-
V
V
K
K
L
D
S
S
I
T
I
A
D
H
-
V
V
S
P
T
L
I
H
K
I
I
T
E
1
PsiBlast_PDB
98.84
96%
-89
- C3 -
3H5Q
3
PDP_STAAC
A:
[5-436]
-
R
M
I
D
I
I
E
K
K
R
D
G
H
T
L
T
T
E
E
I
N
F
F
I
G
G
Y
V
K
G
D
I
P
D
Y
Q
A
S
S
L
A
M
A
I
Y
F
Q
D
M
N
D
D
E
R
V
A
L
T
M
A
M
V
N
S
G
D
M
I
D
L
S
D
-
I
--
K
G
V
K
V
D
K
H
S
T
G
G
V
G
D
T
T
T
L
V
L
A
P
L
V
A
A
V
D
V
P
V
A
K
M
S
G
R
G
L
G
H
T
G
G
T
I
D
K
L
E
A
I
D
G
F
H
V
E
I
D
E
A
T
F
V
K
L
V
N
E
N
K
V
A
V
V
G
Q
S
G
N
L
T
P
A
D
K
K
L
Y
A
L
R
D
V
T
G
T
V
N
S
I
-
P
L
I
A
S
S
I
M
S
K
K
I
A
A
G
A
D
A
I
V
L
D
V
K
T
G
S
G
A
F
M
K
T
L
E
D
A
E
A
L
A
H
A
M
V
R
I
G
N
N
V
G
R
N
T
M
A
I
I
S
D
M
N
Q
P
L
G
R
A
I
G
N
A
L
E
L
Q
E
A
I
D
T
L
K
G
Q
--
G
P
K
D
L
T
E
L
V
L
T
L
G
S
Q
M
V
V
L
A
N
K
A
E
T
L
E
E
A
R
A
L
L
I
E
A
I
N
S
G
A
A
L
E
K
F
K
T
F
I
K
N
Q
G
G
D
-
E
---------
T
V
I
D
H
P
E
---------
R
L
P
Q
A
Q
Y
Q
I
E
Y
K
A
K
K
S
G
Y
V
T
E
L
V
S
N
D
I
G
V
A
S
M
M
L
G
A
G
R
L
T
K
E
D
D
I
D
L
A
V
G
I
V
L
N
K
K
I
G
D
K
V
E
E
G
E
S
L
L
T
I
H
S
N
R
Q
-
D
V
D
D
V
V
K
K
L
D
S
S
I
T
I
A
D
H
-
V
V
S
P
T
L
I
H
K
I
I
T
E
21
PsiBlast_CBE
90.98
68%
-86
- C3 -
1BRW
3
PDP_GEOSE
A:
[1-432]
M
R
M
V
D
L
I
A
K
K
R
D
G
K
A
L
T
K
E
E
I
E
W
I
V
R
G
Y
T
N
G
D
I
P
D
Y
Q
M
S
A
L
A
M
A
I
Y
F
R
G
M
T
E
E
E
T
A
A
L
T
M
A
M
V
Q
S
G
E
M
L
D
L
S
S
-
I
--
R
G
V
K
V
D
K
H
S
T
G
G
V
G
D
T
T
T
L
V
L
G
P
L
V
A
S
V
G
V
P
V
A
K
M
S
G
R
G
L
G
H
T
G
G
T
I
D
K
L
E
S
V
P
G
F
H
V
E
I
S
K
D
E
F
I
R
L
V
N
E
N
G
I
A
I
I
G
Q
T
G
D
L
T
P
A
D
K
K
L
Y
A
L
R
D
V
T
A
T
V
N
S
I
-
P
L
I
A
S
S
I
M
S
K
K
I
A
A
G
A
D
A
I
V
L
D
V
K
T
G
A
G
A
F
M
K
K
L
D
E
A
R
R
L
A
R
V
M
V
D
I
G
K
R
V
G
R
R
T
M
A
V
I
S
D
M
S
Q
P
L
G
Y
A
V
G
N
A
L
E
V
K
E
A
I
E
T
L
K
G
N
--
G
P
H
D
L
T
E
L
C
L
T
L
G
S
H
M
V
Y
L
A
E
K
A
P
S
L
D
E
A
R
R
L
L
E
E
A
I
R
S
G
A
A
I
A
A
F
K
T
F
L
A
A
Q
G
G
D
-
A
---------
S
V
V
D
D
L
D
---------
K
L
P
K
A
A
Y
T
S
T
V
T
A
A
A
D
G
Y
V
A
E
M
A
A
D
D
I
G
T
A
A
M
W
L
G
A
G
R
A
K
K
E
D
V
I
D
L
A
V
G
I
V
L
H
K
K
I
G
D
R
V
Q
K
G
E
A
L
A
T
I
H
S
N
R
P
-
D
V
L
D
V
K
E
K
I
E
A
A
I
R
L
S
P
Q
P
V
A
R
P
P
L
I
Y
E
T
I
--
31
HHSearch
89.97
67%
-81
- C3 -
1BRW
3
PDP_GEOSE
A:
[1-433]
M
R
M
V
D
L
I
A
K
K
R
D
G
K
A
L
T
K
E
E
I
E
W
I
V
R
G
Y
T
N
G
D
I
P
D
Y
Q
M
S
A
L
A
M
A
I
Y
F
R
G
M
T
E
E
E
T
A
A
L
T
M
A
M
V
Q
S
G
E
M
L
D
L
S
S
-
I
--
R
G
V
K
V
D
K
H
S
T
G
G
V
G
D
T
T
T
L
V
L
G
P
L
V
A
S
V
G
V
P
V
A
K
M
S
G
R
G
L
G
H
T
G
G
T
I
D
K
L
E
S
V
P
G
F
H
V
E
I
S
K
D
E
F
I
R
L
V
N
E
N
G
I
A
I
I
G
Q
T
G
D
L
T
P
A
D
K
K
L
Y
A
L
R
D
V
-
T
A
T
V
N
S
I
P
L
I
A
S
S
I
M
S
K
K
I
A
A
G
A
D
A
I
V
L
D
V
K
T
G
A
G
A
F
M
K
K
L
D
E
A
R
R
L
A
R
V
M
V
D
I
G
K
R
V
G
R
R
T
M
A
V
I
S
D
M
S
Q
P
L
G
Y
A
V
G
N
A
L
E
V
K
E
A
I
E
T
L
K
G
N
--
G
P
H
D
L
T
E
L
C
L
T
L
G
S
H
M
V
Y
L
A
E
K
A
P
S
L
D
E
A
R
R
L
L
E
E
A
I
R
S
G
A
A
I
A
A
F
K
T
F
L
A
A
Q
G
G
D
-
A
---------
S
V
V
D
D
L
D
---------
K
L
P
K
A
A
Y
T
S
T
V
T
A
A
A
D
G
Y
V
A
E
M
A
A
D
D
I
G
T
A
A
M
W
L
G
A
G
R
A
K
K
E
D
V
I
D
L
A
V
G
I
V
L
H
K
K
I
G
D
R
V
Q
K
G
E
A
L
A
T
I
H
S
N
R
P
D
V
L
D
V
-
K
E
K
I
E
A
A
I
R
L
S
P
Q
P
V
A
R
P
P
L
I
Y
E
T
I
V
-
2
PsiBlast_PDB
89.37
68%
-85
- C3 -
1BRW
4
PDP_GEOSE
B:
[1-432]
M
R
M
V
D
L
I
A
K
K
R
D
G
K
A
L
T
K
E
E
I
E
W
I
V
R
G
Y
T
N
G
D
I
P
D
Y
Q
M
S
A
L
A
M
A
I
Y
F
R
G
M
T
E
E
E
T
A
A
L
T
M
A
M
V
Q
S
G
E
M
L
D
L
S
S
-
I
--
R
G
V
K
V
D
K
H
S
T
G
G
V
G
D
T
T
T
L
V
L
G
P
L
V
A
S
V
G
V
P
V
A
K
M
S
G
R
G
L
G
H
T
G
G
T
I
D
K
L
E
S
V
P
G
F
H
V
E
I
S
K
D
E
F
I
R
L
V
N
E
N
G
I
A
I
I
G
Q
T
G
D
L
T
P
A
D
K
K
L
Y
A
L
R
D
V
T
A
T
V
N
S
I
-
P
L
I
A
S
S
I
M
S
K
K
I
A
A
G
A
D
A
I
V
L
D
V
K
T
G
A
G
A
F
M
K
K
L
D
E
A
R
R
L
A
R
V
M
V
D
I
G
K
R
V
G
R
R
T
M
A
V
I
S
D
M
S
Q
P
L
G
Y
A
V
G
N
A
L
E
V
K
E
A
I
E
T
L
K
G
N
--
G
P
H
D
L
T
E
L
C
L
T
L
G
S
H
M
V
Y
L
A
E
K
A
P
S
L
D
E
A
R
R
L
L
E
E
A
I
R
S
G
A
A
I
A
A
F
K
T
F
L
A
A
Q
G
G
D
-
A
---------
S
V
V
D
D
L
D
---------
K
L
P
K
A
A
Y
T
S
T
V
T
A
A
A
D
G
Y
V
A
E
M
A
A
D
D
I
G
T
A
A
M
W
L
G
A
G
R
A
K
K
E
D
V
I
D
L
A
V
G
I
V
L
H
K
K
I
G
D
R
V
Q
K
G
E
A
L
A
T
I
H
S
N
R
P
-
D
V
L
D
V
K
E
K
I
E
A
A
I
R
L
S
P
Q
P
V
A
R
P
P
L
I
Y
E
T
I
--
22
PsiBlast_CBE
80.97
44%
-77
- C3 -
2DSJ
2
?
B:
[1-423]
M
N
P
V
A
F
I
R
E
K
R
E
G
K
K
H
R
R
E
D
L
E
A
F
L
L
G
Y
L
R
D
E
V
P
D
Y
Q
V
S
A
W
L
M
A
A
F
L
R
G
L
D
P
E
E
T
L
W
L
T
E
T
M
A
R
S
G
K
V
L
D
L
S
G
-
L
--
P
H
-
P
V
D
K
H
S
S
G
G
V
G
D
K
V
S
L
V
V
G
P
I
L
A
A
S
G
C
T
F
A
K
M
S
G
R
G
L
A
H
T
G
G
T
I
D
K
L
E
S
V
P
G
W
R
G
E
M
T
E
A
E
F
L
E
R
A
R
R
V
G
L
V
I
A
A
Q
S
P
D
L
A
P
L
D
G
K
L
Y
A
L
R
D
V
T
A
T
V
E
S
V
-
P
L
I
A
S
S
I
M
S
K
K
L
A
A
G
A
R
S
I
V
L
D
V
K
V
G
R
G
A
F
M
K
T
L
E
E
A
R
L
L
A
K
T
M
V
A
I
G
Q
G
A
G
R
R
V
R
A
L
L
T
S
M
E
A
P
L
G
R
A
V
G
N
A
I
E
V
R
E
A
I
E
A
L
K
G
E
--
G
P
G
D
L
L
E
V
A
L
A
L
A
E
E
A
L
R
L
----
E
G
L
D
P
--
A
L
A
R
K
A
L
E
G
G
A
A
L
E
K
F
R
A
F
L
E
A
Q
G
G
D
-
P
---------
R
A
V
E
D
F
S
---------
L
L
P
L
A
E
-
E
H
P
L
R
A
E
R
E
G
V
V
R
E
V
D
A
Y
K
V
G
L
A
V
L
A
L
G
G
G
R
K
R
K
G
E
P
I
D
H
G
V
G
V
Y
L
L
K
K
P
G
D
R
V
E
R
G
E
A
L
A
L
V
Y
H
R
R
R
-
G
L
E
E
A
L
G
H
L
R
E
A
Y
A
L
G
E
E
-
A
H
P
A
P
L
V
L
E
A
I
--
3
PsiBlast_PDB
80.70
44%
-71
- C3 -
2DSJ
2
?
A:
[1-423]
M
N
P
V
A
F
I
R
E
K
R
E
G
K
K
H
R
R
E
D
L
E
A
F
L
L
G
Y
L
R
D
E
V
P
D
Y
Q
V
S
A
W
L
M
A
A
F
L
R
G
L
D
P
E
E
T
L
W
L
T
E
T
M
A
R
S
G
K
V
L
D
L
S
G
-
L
--
P
H
-
P
V
D
K
H
S
S
G
G
V
G
D
K
V
S
L
V
V
G
P
I
L
A
A
S
G
C
T
F
A
K
M
S
G
R
G
L
A
H
T
G
G
T
I
D
K
L
E
S
V
P
G
W
R
G
E
M
T
E
A
E
F
L
E
R
A
R
R
V
G
L
V
I
A
A
Q
S
P
D
L
A
P
L
D
G
K
L
Y
A
L
R
D
V
T
A
T
V
E
S
V
-
P
L
I
A
S
S
I
M
S
K
K
L
A
A
G
A
R
S
I
V
L
D
V
K
V
G
R
G
A
F
M
K
T
L
E
E
A
R
L
L
A
K
T
M
V
A
I
G
Q
G
A
G
R
R
V
R
A
L
L
T
S
M
E
A
P
L
G
R
A
V
G
N
A
I
E
V
R
E
A
I
E
A
L
K
G
E
--
G
P
G
D
L
L
E
V
A
L
A
L
A
E
E
A
L
R
L
----
E
G
L
D
P
--
A
L
A
R
K
A
L
E
G
G
A
A
L
E
K
F
R
A
F
L
E
A
Q
G
G
D
-
P
---------
R
A
V
E
D
F
S
---------
L
L
P
L
A
E
-
E
H
P
L
R
A
E
R
E
G
V
V
R
E
V
D
A
Y
K
V
G
L
A
V
L
A
L
G
G
G
R
K
R
K
G
E
P
I
D
H
G
V
G
V
Y
L
L
K
K
P
G
D
R
V
E
R
G
E
A
L
A
L
V
Y
H
R
R
R
-
G
L
E
E
A
L
G
H
L
R
E
A
Y
A
L
G
E
E
-
A
H
P
A
P
L
V
L
E
A
I
--
29
HHSearch
80.02
45%
-71
- C3 -
2DSJ
2
?
A:
[1-423]
M
N
P
V
A
F
I
R
E
K
R
E
G
K
K
H
R
R
E
D
L
E
A
F
L
L
G
Y
L
R
D
E
V
P
D
Y
Q
V
S
A
W
L
M
A
A
F
L
R
G
L
D
P
E
E
T
L
W
L
T
E
T
M
A
R
S
G
K
V
L
D
L
S
G
-
L
---
P
H
P
V
D
K
H
S
S
G
G
V
G
D
K
V
S
L
V
V
G
P
I
L
A
A
S
G
C
T
F
A
K
M
S
G
R
G
L
A
H
T
G
G
T
I
D
K
L
E
S
V
P
G
W
R
G
E
M
T
E
A
E
F
L
E
R
A
R
R
V
G
L
V
I
A
A
Q
S
P
D
L
A
P
L
D
G
K
L
Y
A
L
R
D
V
T
A
T
V
E
S
V
-
P
L
I
A
S
S
I
M
S
K
K
L
A
A
G
A
R
S
I
V
L
D
V
K
V
G
R
G
A
F
M
K
T
L
E
E
A
R
L
L
A
K
T
M
V
A
I
G
Q
G
A
G
R
R
V
R
A
L
L
T
S
M
E
A
P
L
G
R
A
V
G
N
A
I
E
V
R
E
A
I
E
A
L
K
G
E
--
G
P
G
D
L
L
E
V
A
L
A
L
A
E
E
A
L
R
L
E
G
L
------
D
P
A
L
A
R
K
A
L
E
G
G
A
A
L
E
K
F
R
A
F
L
E
A
Q
G
G
D
-
P
---------
R
A
V
E
D
F
----------
S
L
L
P
L
A
E
E
H
P
L
R
A
E
R
E
G
V
V
R
E
V
D
A
Y
K
V
G
L
A
V
L
A
L
G
G
G
R
K
R
K
G
E
P
I
D
H
G
V
G
V
Y
L
L
K
K
P
G
D
R
V
E
R
G
E
A
L
A
L
V
Y
H
R
R
R
-
G
L
E
E
A
L
G
H
L
R
E
A
Y
A
L
G
E
E
A
H
-
P
A
P
L
V
L
E
A
I
--
9
PsiBlast_PDB
77.46
44%
-69
- C3 -
4EAF
8
TYPH_ECOLI
A:
[6-408]
----
E
I
I
R
K
K
R
D
G
H
A
L
S
D
E
E
I
R
F
F
I
N
G
I
R
D
N
T
I
S
E
G
Q
I
A
A
L
A
M
T
I
F
F
H
D
M
T
M
P
E
R
V
S
L
T
M
A
M
R
D
S
G
T
V
L
D
W
K
S
-
L
HL
N
G
P
I
V
D
K
H
S
T
G
G
V
G
D
V
T
S
L
M
L
G
P
M
V
A
A
C
G
G
Y
I
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
D
I
F
P
D
D
N
R
F
R
E
I
I
K
D
V
G
V
A
I
I
G
Q
T
S
S
L
A
P
A
D
K
R
F
Y
A
T
R
D
I
T
A
T
V
D
S
I
-
P
L
I
T
A
S
I
L
A
K
K
L
A
E
G
L
D
A
L
V
M
D
V
K
V
G
S
G
A
F
M
P
T
Y
E
L
S
E
A
L
A
E
A
I
V
G
V
A
N
G
A
G
V
R
T
T
A
L
L
T
D
M
N
Q
V
L
A
S
S
A
G
N
A
V
E
V
R
E
A
V
Q
F
L
T
G
E
YR
N
P
R
-
L
F
D
V
T
M
A
L
C
V
E
M
L
I
S
G
K
L
A
K
D
D
A
E
A
R
A
K
L
Q
A
V
L
D
N
G
K
A
A
E
V
F
G
R
M
V
A
A
Q
K
G
P
T
D
---------
F
V
E
N
Y
A
K
---------
Y
L
P
T
A
M
L
T
K
A
V
Y
A
D
T
E
G
F
V
S
E
M
D
T
R
A
L
G
M
A
V
V
A
M
G
G
G
R
R
Q
A
S
D
T
I
D
Y
S
V
G
F
T
D
M
A
R
L
G
D
Q
V
D
G
Q
R
P
L
A
V
I
H
A
K
D
E
-
N
-------------------------------
10
PsiBlast_PDB
77.37
44%
-66
- C3 -
4LHM
9
TYPH_ECOLI
A:
[6-408]
----
E
I
I
R
K
K
R
D
G
H
A
L
S
D
E
E
I
R
F
F
I
N
G
I
R
D
N
T
I
S
E
G
Q
I
A
A
L
A
M
T
I
F
F
H
D
M
T
M
P
E
R
V
S
L
T
M
A
M
R
D
S
G
T
V
L
D
W
K
S
-
L
HL
N
G
P
I
V
D
K
H
S
T
G
G
V
G
D
V
T
S
L
M
L
G
P
M
V
A
A
C
G
G
Y
I
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
D
I
F
P
D
D
N
R
F
R
E
I
I
K
D
V
G
V
A
I
I
G
Q
T
S
S
L
A
P
A
D
K
R
F
Y
A
T
R
D
I
T
A
T
V
D
S
I
-
P
L
I
T
A
S
I
L
A
K
K
L
A
E
G
L
D
A
L
V
M
D
V
K
V
G
S
G
A
F
M
P
T
Y
E
L
S
E
A
L
A
E
A
I
V
G
V
A
N
G
A
G
V
R
T
T
A
L
L
T
D
M
N
Q
V
L
A
S
S
A
G
N
A
V
E
V
R
E
A
V
Q
F
L
T
G
E
YR
N
P
R
-
L
F
D
V
T
M
A
L
C
V
E
M
L
I
S
G
K
L
A
K
D
D
A
E
A
R
A
K
L
Q
A
V
L
D
N
G
K
A
A
E
V
F
G
R
M
V
A
A
Q
K
G
P
T
D
---------
F
V
E
N
Y
A
K
---------
Y
L
P
T
A
M
L
T
K
A
V
Y
A
D
T
E
G
F
V
S
E
M
D
T
R
A
L
G
M
A
V
V
A
M
G
G
G
R
R
Q
A
S
D
T
I
D
Y
S
V
G
F
T
D
M
A
R
L
G
D
Q
V
D
G
Q
R
P
L
A
V
I
H
A
K
D
E
-
N
-------------------------------
8
PsiBlast_PDB
76.98
44%
-67
- C3 -
4EAD
10
TYPH_ECOLI
A:
[6-408]
----
E
I
I
R
K
K
R
D
G
H
A
L
S
D
E
E
I
R
F
F
I
N
G
I
R
D
N
T
I
S
E
G
Q
I
A
A
L
A
M
T
I
F
F
H
D
M
T
M
P
E
R
V
S
L
T
M
A
M
R
D
S
G
T
V
L
D
W
K
S
-
L
HL
N
G
P
I
V
D
K
H
S
T
G
G
V
G
D
V
T
S
L
M
L
G
P
M
V
A
A
C
G
G
Y
I
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
D
I
F
P
D
D
N
R
F
R
E
I
I
K
D
V
G
V
A
I
I
G
Q
T
S
S
L
A
P
A
D
K
R
F
Y
A
T
R
D
I
T
A
T
V
D
S
I
-
P
L
I
T
A
S
I
L
A
K
K
L
A
E
G
L
D
A
L
V
M
D
V
K
V
G
S
G
A
F
M
P
T
Y
E
L
S
E
A
L
A
E
A
I
V
G
V
A
N
G
A
G
V
R
T
T
A
L
L
T
D
M
N
Q
V
L
A
S
S
A
G
N
A
V
E
V
R
E
A
V
Q
F
L
T
G
E
YR
N
P
R
-
L
F
D
V
T
M
A
L
C
V
E
M
L
I
S
G
K
L
A
K
D
D
A
E
A
R
A
K
L
Q
A
V
L
D
N
G
K
A
A
E
V
F
G
R
M
V
A
A
Q
K
G
P
T
D
---------
F
V
E
N
Y
A
K
---------
Y
L
P
T
A
M
L
T
K
A
V
Y
A
D
T
E
G
F
V
S
E
M
D
T
R
A
L
G
M
A
V
V
A
M
G
G
G
R
R
Q
A
S
D
T
I
D
Y
S
V
G
F
T
D
M
A
R
L
G
D
Q
V
D
G
Q
R
P
L
A
V
I
H
A
K
D
E
-
N
-------------------------------
5
PsiBlast_PDB
76.85
44%
-66
- C3 -
1OTP
-
TYPH_ECOLI
A:
[6-408]
----
E
I
I
R
K
K
R
D
G
H
A
L
S
D
E
E
I
R
F
F
I
N
G
I
R
D
N
T
I
S
E
G
Q
I
A
A
L
A
M
T
I
F
F
H
D
M
T
M
P
E
R
V
S
L
T
M
A
M
R
D
S
G
T
V
L
D
W
K
S
-
L
HL
N
G
P
I
V
D
K
H
S
T
G
G
V
G
D
V
T
S
L
M
L
G
P
M
V
A
A
C
G
G
Y
I
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
D
I
F
P
D
D
N
R
F
R
E
I
I
K
D
V
G
V
A
I
I
G
Q
T
S
S
L
A
P
A
D
K
R
F
Y
A
T
R
D
I
T
A
T
V
D
S
I
-
P
L
I
T
A
S
I
L
A
K
K
L
A
E
G
L
D
A
L
V
M
D
V
K
V
G
S
G
A
F
M
P
T
Y
E
L
S
E
A
L
A
E
A
I
V
G
V
A
N
G
A
G
V
R
T
T
A
L
L
T
D
M
N
Q
V
L
A
S
S
A
G
N
A
V
E
V
R
E
A
V
Q
F
L
T
G
E
YR
N
P
R
-
L
F
D
V
T
M
A
L
C
V
E
M
L
I
S
G
K
L
A
K
D
D
A
E
A
R
A
K
L
Q
A
V
L
D
N
G
K
A
A
E
V
F
G
R
M
V
A
A
Q
K
G
P
T
D
---------
F
V
E
N
Y
A
K
---------
Y
L
P
T
A
M
L
T
K
A
V
Y
A
D
T
E
G
F
V
S
E
M
D
T
R
A
L
G
M
A
V
V
A
M
G
G
G
R
R
Q
A
S
D
T
I
D
Y
S
V
G
F
T
D
M
A
R
L
G
D
Q
V
D
G
Q
R
P
L
A
V
I
H
A
K
D
E
-
N
-------------------------------
7
PsiBlast_PDB
76.83
44%
-66
- C3 -
2TPT
1
TYPH_ECOLI
A:
[6-408]
----
E
I
I
R
K
K
R
D
G
H
A
L
S
D
E
E
I
R
F
F
I
N
G
I
R
D
N
T
I
S
E
G
Q
I
A
A
L
A
M
T
I
F
F
H
D
M
T
M
P
E
R
V
S
L
T
M
A
M
R
D
S
G
T
V
L
D
W
K
S
-
L
HL
N
G
P
I
V
D
K
H
S
T
G
G
V
G
D
V
T
S
L
M
L
G
P
M
V
A
A
C
G
G
Y
I
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
D
I
F
P
D
D
N
R
F
R
E
I
I
K
D
V
G
V
A
I
I
G
Q
T
S
S
L
A
P
A
D
K
R
F
Y
A
T
R
D
I
T
A
T
V
D
S
I
-
P
L
I
T
A
S
I
L
A
K
K
L
A
E
G
L
D
A
L
V
M
D
V
K
V
G
S
G
A
F
M
P
T
Y
E
L
S
E
A
L
A
E
A
I
V
G
V
A
N
G
A
G
V
R
T
T
A
L
L
T
D
M
N
Q
V
L
A
S
S
A
G
N
A
V
E
V
R
E
A
V
Q
F
L
T
G
E
YR
N
P
R
-
L
F
D
V
T
M
A
L
C
V
E
M
L
I
S
G
K
L
A
K
D
D
A
E
A
R
A
K
L
Q
A
V
L
D
N
G
K
A
A
E
V
F
G
R
M
V
A
A
Q
K
G
P
T
D
---------
F
V
E
N
Y
A
K
---------
Y
L
P
T
A
M
L
T
K
A
V
Y
A
D
T
E
G
F
V
S
E
M
D
T
R
A
L
G
M
A
V
V
A
M
G
G
G
R
R
Q
A
S
D
T
I
D
Y
S
V
G
F
T
D
M
A
R
L
G
D
Q
V
D
G
Q
R
P
L
A
V
I
H
A
K
D
E
-
N
-------------------------------
4
PsiBlast_PDB
75.91
44%
-66
- C3 -
1AZY
-
TYPH_ECOLI
A:
[6-408]
----
E
I
I
R
K
K
R
D
G
H
A
L
S
D
E
E
I
R
F
F
I
N
G
I
R
D
N
T
I
S
E
G
Q
I
A
A
L
A
M
T
I
F
F
H
D
M
T
M
P
E
R
V
S
L
T
M
A
M
R
D
S
G
T
V
L
D
W
K
S
-
L
HL
N
G
P
I
V
D
K
H
S
T
G
G
V
G
D
V
T
S
L
M
L
G
P
M
V
A
A
C
G
G
Y
I
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
D
I
F
P
D
D
N
R
F
R
E
I
I
K
D
V
G
V
A
I
I
G
Q
T
S
S
L
A
P
A
D
K
R
F
Y
A
T
R
D
I
T
A
T
V
D
S
I
-
P
L
I
T
A
S
I
L
A
K
K
L
A
E
G
L
D
A
L
V
M
D
V
K
V
G
S
G
A
F
M
P
T
Y
E
L
S
E
A
L
A
E
A
I
V
G
V
A
N
G
A
G
V
R
T
T
A
L
L
T
D
M
N
Q
V
L
A
S
S
A
G
N
A
V
E
V
R
E
A
V
Q
F
L
T
G
E
YR
N
P
R
-
L
F
D
V
T
M
A
L
C
V
E
M
L
I
S
G
K
L
A
K
D
D
A
E
A
R
A
K
L
Q
A
V
L
D
N
G
K
A
A
E
V
F
G
R
M
V
A
A
Q
K
G
P
T
D
---------
F
V
E
N
Y
A
K
---------
Y
L
P
T
A
M
L
T
K
A
V
Y
A
D
T
E
G
F
V
S
E
M
D
T
R
A
L
G
M
A
V
V
A
M
G
G
G
R
R
Q
A
S
D
T
I
D
Y
S
V
G
F
T
D
M
A
R
L
G
D
Q
V
D
G
Q
R
P
L
A
V
I
H
A
K
D
E
-
N
-------------------------------
25
PsiBlast_CBE
74.56
38%
-67
- C3 -
2WK6
1
TYPH_HUMAN
B:
[35-443]
-
Q
L
P
E
L
I
R
M
K
R
D
G
G
R
L
S
E
A
D
I
R
G
F
V
A
A
V
V
N
G
S
A
Q
G
A
Q
I
G
A
M
L
M
A
I
R
L
R
G
M
D
L
E
E
T
S
V
L
T
Q
A
L
A
Q
S
G
Q
Q
L
E
W
P
E
A
W
--
R
Q
Q
L
V
D
K
H
S
T
G
G
V
G
D
K
V
S
L
V
L
A
P
A
L
A
A
C
G
C
K
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
N
V
I
Q
S
P
E
Q
M
Q
V
L
L
D
Q
A
G
C
C
I
V
G
Q
S
E
Q
L
V
P
A
D
G
I
L
Y
A
A
R
D
V
T
A
T
V
D
S
L
-
P
L
I
T
A
S
I
L
S
K
K
L
V
E
G
L
S
A
L
V
V
D
V
K
F
G
G
A
A
V
F
P
N
Q
E
Q
A
R
E
L
A
K
T
L
V
G
V
G
A
S
L
G
L
R
V
A
A
A
L
T
A
M
D
K
P
L
G
R
C
V
G
H
A
L
E
V
E
E
A
L
L
C
M
D
G
A
--
G
P
P
D
L
R
D
L
V
T
T
L
G
G
A
L
L
W
L
S
G
H
A
G
T
Q
A
Q
G
A
A
R
V
A
A
A
L
D
D
G
S
A
L
G
R
F
E
R
M
L
A
A
Q
G
V
D
-
P
GLARALCSG
S
P
A
E
R
R
Q
---------
L
L
P
R
A
R
E
Q
E
E
L
L
A
P
A
D
G
T
V
E
L
V
R
A
L
P
L
A
L
V
L
H
E
L
G
A
G
R
S
R
A
G
E
P
L
R
L
G
V
G
A
E
L
L
V
D
V
G
Q
R
L
R
R
G
T
P
W
L
R
V
H
R
D
-----------------------------------
30
HHSearch
74.35
37%
-71
* C3 *
1UOU
1
TYPH_HUMAN
A:
[28-469]
K
Q
L
P
E
L
I
R
M
K
R
D
G
G
R
L
S
E
A
D
I
R
G
F
V
A
A
V
V
N
G
S
A
Q
G
A
Q
I
G
A
M
L
M
A
I
R
L
R
G
M
D
L
E
E
T
S
V
L
T
Q
A
L
A
Q
S
G
Q
Q
L
E
W
P
E
-
A
W-
R
Q
Q
L
V
D
K
H
S
T
G
G
V
G
D
K
V
S
L
V
L
A
P
A
L
A
A
C
G
C
K
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
N
V
I
Q
S
P
E
Q
M
Q
V
L
L
D
Q
A
G
C
C
I
V
G
Q
S
E
Q
L
V
P
A
D
G
I
L
Y
A
A
R
D
V
T
A
T
V
D
S
L
-
P
L
I
T
A
S
I
L
S
K
K
L
V
E
G
L
S
A
L
V
V
D
V
K
F
G
--
A
V
F
P
N
Q
E
Q
A
R
E
L
A
K
T
L
V
G
V
G
A
S
L
G
L
R
V
A
A
A
L
T
A
M
D
K
P
L
G
R
C
V
G
H
A
L
E
V
E
E
A
L
L
C
M
D
G
A
--
G
P
P
D
L
R
D
L
V
T
T
L
G
G
A
L
L
W
L
S
G
H
A
G
T
Q
A
Q
G
A
A
R
V
A
A
A
L
D
D
G
S
A
L
G
R
F
E
R
M
L
A
A
Q
G
V
D
-
P
---------
G
L
A
R
A
L
C
S
GS
P
A
E
R
R
Q
L
L
P
R
A
R
E
Q
E
E
L
L
A
P
A
D
G
T
V
E
L
V
R
A
L
P
L
A
L
V
L
H
E
L
G
A
--------
L
R
L
G
V
G
A
E
L
L
V
D
V
G
Q
R
L
R
R
G
T
P
W
L
R
V
H
R
D
G
P
A
L
S
G
P
Q
S
R
A
L
Q
E
A
L
V
L
S
D
R
A
P
F
A
A
P
L
P
F
A
E
L
V
-
24
PsiBlast_CBE
74.22
38%
-64
- C3 -
2J0F
1
TYPH_HUMAN
B:
[35-443]
-
Q
L
P
E
L
I
R
M
K
R
D
G
G
R
L
S
E
A
D
I
R
G
F
V
A
A
V
V
N
G
S
A
Q
G
A
Q
I
G
A
M
L
M
A
I
R
L
R
G
M
D
L
E
E
T
S
V
L
T
Q
A
L
A
Q
S
G
Q
Q
L
E
W
P
E
A
W
--
R
Q
Q
L
V
D
K
H
S
T
G
G
V
G
D
K
V
S
L
V
L
A
P
A
L
A
A
C
G
C
K
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
N
V
I
Q
S
P
E
Q
M
Q
V
L
L
D
Q
A
G
C
C
I
V
G
Q
S
E
Q
L
V
P
A
D
G
I
L
Y
A
A
R
D
V
T
A
T
V
D
S
L
-
P
L
I
T
A
S
I
L
S
K
K
L
V
E
G
L
S
A
L
V
V
D
V
K
F
G
A
G
A
V
F
P
N
Q
E
Q
A
R
E
L
A
K
T
L
V
G
V
G
A
S
L
G
L
R
V
A
A
A
L
T
A
M
D
K
P
L
G
R
C
V
G
H
A
L
E
V
E
E
A
L
L
C
M
D
G
A
--
G
P
P
D
L
R
D
L
V
T
T
L
G
G
A
L
L
W
L
S
G
H
A
G
T
Q
A
Q
G
A
A
R
V
A
A
A
L
D
D
G
S
A
L
G
R
F
E
R
M
L
A
A
Q
G
V
D
-
P
GLARALCSG
S
P
A
E
R
R
Q
---------
L
L
P
R
A
R
E
Q
E
E
L
L
A
P
A
D
G
T
V
E
L
V
R
A
L
P
L
A
L
V
L
H
E
L
G
A
G
R
S
R
A
G
E
P
L
R
L
G
V
G
A
E
L
L
V
D
V
G
Q
R
L
R
R
G
T
P
W
L
R
V
H
R
D
-----------------------------------
23
PsiBlast_CBE
74.20
38%
-65
- C3 -
2J0F
1
TYPH_HUMAN
C:
[35-443]
-
Q
L
P
E
L
I
R
M
K
R
D
G
G
R
L
S
E
A
D
I
R
G
F
V
A
A
V
V
N
G
S
A
Q
G
A
Q
I
G
A
M
L
M
A
I
R
L
R
G
M
D
L
E
E
T
S
V
L
T
Q
A
L
A
Q
S
G
Q
Q
L
E
W
P
E
A
W
--
R
Q
Q
L
V
D
K
H
S
T
G
G
V
G
D
K
V
S
L
V
L
A
P
A
L
A
A
C
G
C
K
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
N
V
I
Q
S
P
E
Q
M
Q
V
L
L
D
Q
A
G
C
C
I
V
G
Q
S
E
Q
L
V
P
A
D
G
I
L
Y
A
A
R
D
V
T
A
T
V
D
S
L
-
P
L
I
T
A
S
I
L
S
K
K
L
V
E
G
L
S
A
L
V
V
D
V
K
F
G
A
G
A
V
F
P
N
Q
E
Q
A
R
E
L
A
K
T
L
V
G
V
G
A
S
L
G
L
R
V
A
A
A
L
T
A
M
D
K
P
L
G
R
C
V
G
H
A
L
E
V
E
E
A
L
L
C
M
D
G
A
--
G
P
P
D
L
R
D
L
V
T
T
L
G
G
A
L
L
W
L
S
G
H
A
G
T
Q
A
Q
G
A
A
R
V
A
A
A
L
D
D
G
S
A
L
G
R
F
E
R
M
L
A
A
Q
G
V
D
-
P
GLARALCSG
S
P
A
E
R
R
Q
---------
L
L
P
R
A
R
E
Q
E
E
L
L
A
P
A
D
G
T
V
E
L
V
R
A
L
P
L
A
L
V
L
H
E
L
G
A
G
R
S
R
A
G
E
P
L
R
L
G
V
G
A
E
L
L
V
D
V
G
Q
R
L
R
R
G
T
P
W
L
R
V
H
R
D
-----------------------------------
11
PsiBlast_PDB
73.92
38%
-66
- C3 -
2J0F
1
TYPH_HUMAN
A:
[35-443]
-
Q
L
P
E
L
I
R
M
K
R
D
G
G
R
L
S
E
A
D
I
R
G
F
V
A
A
V
V
N
G
S
A
Q
G
A
Q
I
G
A
M
L
M
A
I
R
L
R
G
M
D
L
E
E
T
S
V
L
T
Q
A
L
A
Q
S
G
Q
Q
L
E
W
P
E
A
W
--
R
Q
Q
L
V
D
K
H
S
T
G
G
V
G
D
K
V
S
L
V
L
A
P
A
L
A
A
C
G
C
K
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
N
V
I
Q
S
P
E
Q
M
Q
V
L
L
D
Q
A
G
C
C
I
V
G
Q
S
E
Q
L
V
P
A
D
G
I
L
Y
A
A
R
D
V
T
A
T
V
D
S
L
-
P
L
I
T
A
S
I
L
S
K
K
L
V
E
G
L
S
A
L
V
V
D
V
K
F
G
A
G
A
V
F
P
N
Q
E
Q
A
R
E
L
A
K
T
L
V
G
V
G
A
S
L
G
L
R
V
A
A
A
L
T
A
M
D
K
P
L
G
R
C
V
G
H
A
L
E
V
E
E
A
L
L
C
M
D
G
A
--
G
P
P
D
L
R
D
L
V
T
T
L
G
G
A
L
L
W
L
S
G
H
A
G
T
Q
A
Q
G
A
A
R
V
A
A
A
L
D
D
G
S
A
L
G
R
F
E
R
M
L
A
A
Q
G
V
D
-
P
G
L
A
R
A
L
C
S
G
S
P
A
E
R
R
Q
---------
L
L
P
R
A
R
E
Q
E
E
L
L
A
P
A
D
G
T
V
E
L
V
R
A
L
P
L
A
L
V
L
H
E
L
G
A
G
R
S
R
A
G
E
P
L
R
L
G
V
G
A
E
L
L
V
D
V
G
Q
R
L
R
R
G
T
P
W
L
R
V
H
R
D
-----------------------------------
26
PsiBlast_CBE
73.75
38%
-64
- C3 -
2WK5
1
TYPH_HUMAN
B:
[35-443]
-
Q
L
P
E
L
I
R
M
K
R
D
G
G
R
L
S
E
A
D
I
R
G
F
V
A
A
V
V
N
G
S
A
Q
G
A
Q
I
G
A
M
L
M
A
I
R
L
R
G
M
D
L
E
E
T
S
V
L
T
Q
A
L
A
Q
S
G
Q
Q
L
E
W
P
--
W
--
R
Q
Q
L
V
D
K
H
S
T
G
G
V
G
D
K
V
S
L
V
L
A
P
A
L
A
A
C
G
C
K
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
N
V
I
Q
S
P
E
Q
M
Q
V
L
L
D
Q
A
G
C
C
I
V
G
Q
S
E
Q
L
V
P
A
D
G
I
L
Y
A
A
R
D
V
T
A
T
V
D
S
L
-
P
L
I
T
A
S
I
L
S
K
K
L
V
E
G
L
S
A
L
V
V
D
V
K
F
G
G
A
A
V
F
P
N
Q
E
Q
A
R
E
L
A
K
T
L
V
G
V
G
A
S
L
G
L
R
V
A
A
A
L
T
A
M
D
K
P
L
G
R
C
V
G
H
A
L
E
V
E
E
A
L
L
C
M
D
G
A
--
G
P
P
D
L
R
D
L
V
T
T
L
G
G
A
L
L
W
L
S
G
H
A
G
T
Q
A
Q
G
A
A
R
V
A
A
A
L
D
D
G
S
A
L
G
R
F
E
R
M
L
A
A
Q
G
V
D
-
P
G
L
A
R
A
L
C
S
G
S
P
A
E
R
R
Q
---------
L
L
P
R
A
R
E
Q
E
E
L
L
A
P
A
D
G
T
V
E
L
V
R
A
L
P
L
A
L
V
L
H
E
L
G
A
G
R
S
R
A
G
E
P
L
R
L
G
V
G
A
E
L
L
V
D
V
G
Q
R
L
R
R
G
T
P
W
L
R
V
H
R
D
-----------------------------------
13
PsiBlast_PDB
73.64
38%
-67
- C3 -
2WK6
1
TYPH_HUMAN
A:
[35-443]
-
Q
L
P
E
L
I
R
M
K
R
D
G
G
R
L
S
E
A
D
I
R
G
F
V
A
A
V
V
N
G
S
A
Q
G
A
Q
I
G
A
M
L
M
A
I
R
L
R
G
M
D
L
E
E
T
S
V
L
T
Q
A
L
A
Q
S
G
Q
Q
L
E
W
P
E
A
W
--
R
Q
Q
L
V
D
K
H
S
T
G
G
V
G
D
K
V
S
L
V
L
A
P
A
L
A
A
C
G
C
K
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
N
V
I
Q
S
P
E
Q
M
Q
V
L
L
D
Q
A
G
C
C
I
V
G
Q
S
E
Q
L
V
P
A
D
G
I
L
Y
A
A
R
D
V
T
A
T
V
D
S
L
-
P
L
I
T
A
S
I
L
S
K
K
L
V
E
G
L
S
A
L
V
V
D
V
K
F
G
G
A
A
V
F
P
N
Q
E
Q
A
R
E
L
A
K
T
L
V
G
V
G
A
S
L
G
L
R
V
A
A
A
L
T
A
M
D
K
P
L
G
R
C
V
G
H
A
L
E
V
E
E
A
L
L
C
M
D
G
A
--
G
P
P
D
L
R
D
L
V
T
T
L
G
G
A
L
L
W
L
S
G
H
A
G
T
Q
A
Q
G
A
A
R
V
A
A
A
L
D
D
G
S
A
L
G
R
F
E
R
M
L
A
A
Q
G
V
D
-
P
G
L
A
R
A
L
C
S
G
S
P
A
E
R
R
Q
---------
L
L
P
R
A
R
E
Q
E
E
L
L
A
P
A
D
G
T
V
E
L
V
R
A
L
P
L
A
L
V
L
H
E
L
G
A
G
R
S
R
A
G
E
P
L
R
L
G
V
G
A
E
L
L
V
D
V
G
Q
R
L
R
R
G
T
P
W
L
R
V
H
R
D
-----------------------------------
14
PsiBlast_PDB
72.80
38%
-72
- C3 -
1UOU
1
TYPH_HUMAN
A:
[29-435]
-
Q
L
P
E
L
I
R
M
K
R
D
G
G
R
L
S
E
A
D
I
R
G
F
V
A
A
V
V
N
G
S
A
Q
G
A
Q
I
G
A
M
L
M
A
I
R
L
R
G
M
D
L
E
E
T
S
V
L
T
Q
A
L
A
Q
S
G
Q
Q
L
E
W
P
E
A
W
--
R
Q
Q
L
V
D
K
H
S
T
G
G
V
G
D
K
V
S
L
V
L
A
P
A
L
A
A
C
G
C
K
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
N
V
I
Q
S
P
E
Q
M
Q
V
L
L
D
Q
A
G
C
C
I
V
G
Q
S
E
Q
L
V
P
A
D
G
I
L
Y
A
A
R
D
V
T
A
T
V
D
S
L
-
P
L
I
T
A
S
I
L
S
K
K
L
V
E
G
L
S
A
L
V
V
D
V
K
F
G
--
A
V
F
P
N
Q
E
Q
A
R
E
L
A
K
T
L
V
G
V
G
A
S
L
G
L
R
V
A
A
A
L
T
A
M
D
K
P
L
G
R
C
V
G
H
A
L
E
V
E
E
A
L
L
C
M
D
G
A
--
G
P
P
D
L
R
D
L
V
T
T
L
G
G
A
L
L
W
L
S
G
H
A
G
T
Q
A
Q
G
A
A
R
V
A
A
A
L
D
D
G
S
A
L
G
R
F
E
R
M
L
A
A
Q
G
V
D
-
P
G
L
A
R
A
L
C
S
G
S
P
A
E
R
R
Q
---------
L
L
P
R
A
R
E
Q
E
E
L
L
A
P
A
D
G
T
V
E
L
V
R
A
L
P
L
A
L
V
L
H
E
L
G
A
--------
L
R
L
G
V
G
A
E
L
L
V
D
V
G
Q
R
L
R
R
G
T
P
W
L
R
V
H
R
D
-----------------------------------