@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1965: (2016-03-30 )
MGKYFGTDGVRGVANQELTPELAFKLGRYGGYVLAHNKGEKHPRVLVGRDTRVSGEMLESALIAGLISIGAEVMRLGIISTPGVAYLTRDMGAELGVMISASHNPVADNGIKFFGSDGFKLSDEQENEIEALLDQENPELPRPVGNDIVHYSDYFEGAQKYLSYLKSTVDVNFEGLKIVLDGANGSTSSLAPFLFGDLEADTETIGCSPDGYNINEKCGSTHPEKLAEKVVETESDFGLAFDGDGDRIIAVDENGQIVDGDQIMFIIGQEMHKNQELNNDMIVSTVMSNLGFYKALEQEGIKSNKTKVGDRYVVEEMRRGNYNLGGEQSGHIVMMDYNTTGDGLLTGIQLASVIKMTGKSLSELAGQMKKYPQSLINVRVTDKYRVEENVDVKEVMTKVEVEMNGEGRILVRPSGTEPLVRVMVEAATDEDAERFAQQIADVVQDKMGLDK
Atome Classification :
(20 SA)
.........10.-..-.....20........30........40...-.....50........60........70........80........90........100.......110.......120.......130...-..------..140.......-150.......160.-----......170---.---......-----..180.......190.......200.......210--.......--220-.---..-------....---.230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330....-.-..340.......350.......360..---.....370-...----....380.--.--.---....----.----390------...------......400---------....-----------------...410.......420.......430.......440.......450
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGKYFGTDGVRG-VA-NQEL
T
P
E
L
A
F
K
L
GRYG
G
Y
V
L
A
HNKGEKHP
R
-
V
L
VGRDTRV
S
G
E
M
L
E
S
A
L
I
A
G
L
I
S
I
G
A
E
V
M
R
LGIISTP
G
V
A
Y
L
T
R
D
MGAE
L
G
V
M
I
SASHNPVADN
G
I
K
F
FGSDGFKLSDEQE
N
E
I
E
A
L
LDQ-EN------PELPRPVGNDIV-
H
Y
S
D
Y
F
E
G
A
Q
K
Y
L
S
-----
Y
L
K
S
TVD-----V---NFE
G
L
K
-----
I
V
L
DGANGSTSSL
A
P
F
LFGDLEADTETIGCSPDGY--NI
N
E
KCG--ST--
H
---
P
E
-------
K
L
A
E
---
K
V
V
ETESDF
G
L
A
FDGDG
D
R
I
I
A
VDENG
Q
I
VDGD
Q
I
M
F
I
IG
Q
E
M
HKNQELN
N
D
M
I
V
S
T
V
M
SNL
G
F
Y
K
A
L
E
Q
EGIKSNKTKVG
D
R
Y
V
V
E
E
M
RRGNYNLGGEQS
G
H
I
V
M
M
D-Y-NTTG
D
G
L
L
T
G
I
Q
L
A
S
V
I
K
M
T
G
K
S
L
S
E
L
---
A
G
Q
M
K
K
Y
P
-
Q
S
L
----
I
N
V
R
VT-
D
--
K
--Y---RVEE----N----V--------
D
V
K
------
E
V
M
T
K
V
E
V
E
---------MNGE-----------------
G
R
I
L
V
RPSGT
E
P
L
V
R
V
M
V
EAAT
D
E
D
A
E
R
F
A
Q
Q
I
A
D
V
V
Q
D
K
MGLDK
1
PsiBlast_PDB
99.57
67%
-79
- C1 -
3PDK
3
GLMM_BACAN
A:
[23-467]
-
G
K
Y
F
G
T
D
G
V
R
G
-
V
A
-
N
K
E
L
T
P
E
L
A
F
K
I
G
R
F
G
G
Y
V
L
--
T
K
D
T
D
R
P
K
-
V
I
I
G
R
D
T
R
I
S
G
H
M
L
E
G
A
L
V
A
G
L
L
S
T
G
A
E
V
M
R
L
G
V
I
S
T
P
G
V
A
Y
L
T
K
A
L
D
A
Q
A
G
V
M
I
S
A
S
H
N
P
V
Q
D
N
G
I
K
F
F
G
S
D
G
F
K
L
T
D
E
Q
E
A
E
I
E
A
L
L
D
K
-
E
V
------
D
E
L
P
R
P
T
G
T
N
L
G
-
Q
V
S
D
Y
F
E
G
G
Q
K
Y
L
Q
-----
Y
I
K
Q
T
V
E
-----
E
---
D
F
S
G
L
H
-----
I
A
L
D
C
A
H
G
A
T
S
S
L
A
P
Y
L
F
A
D
L
E
A
D
I
S
T
M
G
T
S
P
N
G
M
--
N
I
N
D
G
V
G
--
S
T
--
H
---
P
E
-------
V
L
A
E
---
L
V
K
E
K
G
A
D
I
G
L
A
F
D
G
D
G
D
R
L
I
A
V
D
E
K
G
N
I
V
D
G
D
Q
I
M
F
I
C
A
K
Y
M
K
E
T
G
Q
L
K
H
N
T
V
V
S
T
V
M
S
N
L
G
F
Y
K
A
L
E
A
N
G
I
T
S
D
K
T
A
V
G
D
R
Y
V
M
E
E
M
K
R
G
G
Y
N
L
G
G
E
Q
S
G
H
I
I
L
L
D
-
Y
-
I
T
T
G
D
G
M
L
S
A
L
Q
L
V
N
I
M
K
M
T
K
K
P
L
S
E
L
---
A
G
E
M
T
K
F
P
-
Q
L
L
----
V
N
V
R
V
T
-
D
--
K
--
K
---
L
A
L
E
----
N
----
E
--------
K
I
K
------
E
I
I
R
V
V
E
E
E
---------
M
N
G
D
-----------------
G
R
I
L
V
R
P
S
G
T
E
P
L
I
R
V
M
A
E
A
P
T
Q
E
V
C
D
A
Y
V
H
R
I
V
E
V
V
K
A
E
V
G
---
25
HHSearch
99.38
67%
-81
- C1 -
3PDK
3
GLMM_BACAN
A:
[23-467]
-
G
K
Y
F
G
T
D
G
V
R
G
-
V
A
-
N
K
E
L
T
P
E
L
A
F
K
I
G
R
F
G
G
Y
V
L
T
K
D
T
--
D
R
P
K
-
V
I
I
G
R
D
T
R
I
S
G
H
M
L
E
G
A
L
V
A
G
L
L
S
T
G
A
E
V
M
R
L
G
V
I
S
T
P
G
V
A
Y
L
T
K
A
L
D
A
Q
A
G
V
M
I
S
A
S
H
N
P
V
Q
D
N
G
I
K
F
F
G
S
D
G
F
K
L
T
D
E
Q
E
A
E
I
E
A
L
L
D
K
-
E
V
------
D
E
L
P
R
P
T
G
T
N
L
G
-
Q
V
S
D
Y
F
E
G
G
Q
K
Y
L
Q
-----
Y
I
K
Q
T
V
E
-----
E
---
D
F
S
G
L
H
-----
I
A
L
D
C
A
H
G
A
T
S
S
L
A
P
Y
L
F
A
D
L
E
A
D
I
S
T
M
G
T
S
P
N
G
M
--
N
I
N
D
G
V
G
--
S
T
--
H
---
P
E
-------
V
L
A
E
---
L
V
K
E
K
G
A
D
I
G
L
A
F
D
G
D
G
D
R
L
I
A
V
D
E
K
G
N
I
V
D
G
D
Q
I
M
F
I
C
A
K
Y
M
K
E
T
G
Q
L
K
H
N
T
V
V
S
T
V
M
S
N
L
G
F
Y
K
A
L
E
A
N
G
I
T
S
D
K
T
A
V
G
D
R
Y
V
M
E
E
M
K
R
G
G
Y
N
L
G
G
E
Q
S
G
H
I
I
L
L
D
-
Y
-
I
T
T
G
D
G
M
L
S
A
L
Q
L
V
N
I
M
K
M
T
K
K
P
L
S
E
L
---
A
G
E
M
T
K
F
P
-
Q
L
L
----
V
N
V
R
V
T
-
D
--
K
--
K
---
L
A
L
E
----
N
----
E
--------
K
I
K
------
E
I
I
R
V
V
E
E
E
---------
M
N
G
D
-----------------
G
R
I
L
V
R
P
S
G
T
E
P
L
I
R
V
M
A
E
A
P
T
Q
E
V
C
D
A
Y
V
H
R
I
V
E
V
V
K
A
E
V
G
---
21
PsiBlast_CBE
98.03
67%
-78
- C1 -
3PDK
5
GLMM_BACAN
B:
[24-467]
--
K
Y
F
G
T
D
G
V
R
G
-
V
A
-
N
K
E
L
T
P
E
L
A
F
K
I
G
R
F
G
G
Y
V
L
--
T
K
D
T
D
R
P
K
-
V
I
I
G
R
D
T
R
I
S
G
H
M
L
E
G
A
L
V
A
G
L
L
S
T
G
A
E
V
M
R
L
G
V
I
S
T
P
G
V
A
Y
L
T
K
A
L
D
A
Q
A
G
V
M
I
S
A
S
H
N
P
V
Q
D
N
G
I
K
F
F
G
S
D
G
F
K
L
T
D
E
Q
E
A
E
I
E
A
L
L
D
K
-
E
V
------
D
E
L
P
R
P
T
G
T
N
L
G
-
Q
V
S
D
Y
F
E
G
G
Q
K
Y
L
Q
-----
Y
I
K
Q
T
V
E
-----
E
---
D
F
S
G
L
H
-----
I
A
L
D
C
A
H
G
A
T
S
S
L
A
P
Y
L
F
A
D
L
E
A
D
I
S
T
M
G
T
S
P
N
G
M
--
N
I
N
D
G
V
G
--
S
T
--
H
---
P
E
-------
V
L
A
E
---
L
V
K
E
K
G
A
D
I
G
L
A
F
D
G
D
G
D
R
L
I
A
V
D
E
K
G
N
I
V
D
G
D
Q
I
M
F
I
C
A
K
Y
M
K
E
T
G
Q
L
K
H
N
T
V
V
S
T
V
M
S
N
L
G
F
Y
K
A
L
E
A
N
G
I
T
S
D
K
T
A
V
G
D
R
Y
V
M
E
E
M
K
R
G
G
Y
N
L
G
G
E
Q
S
G
H
I
I
L
L
D
-
Y
-
I
T
T
G
D
G
M
L
S
A
L
Q
L
V
N
I
M
K
M
T
K
K
P
L
S
E
L
---
A
G
E
M
T
K
F
P
-
Q
L
L
----
V
N
V
R
V
T
-
D
--
K
--
K
---
L
A
L
E
----
N
----
E
--------
K
I
K
------
E
I
I
R
V
V
E
E
E
---------
M
N
G
D
-----------------
G
R
I
L
V
R
P
S
G
T
E
P
L
I
R
V
M
A
E
A
P
T
Q
E
V
C
D
A
Y
V
H
R
I
V
E
V
V
K
A
E
V
G
---
2
PsiBlast_PDB
82.62
38%
-70
- C1 -
3I3W
1
GLMM_FRATT
A:
[3-442]
--
K
Y
F
G
T
D
G
I
R
G
E
V
A
-
N
S
T
I
T
V
E
F
T
Q
K
L
G
N
A
V
G
S
L
I
N
Q
---
K
N
Y
P
K
F
V
I
V
G
Q
D
T
R
S
S
G
G
F
L
K
F
A
L
V
S
G
L
N
A
A
G
I
D
V
L
D
L
G
V
V
P
T
P
V
V
A
F
M
T
V
K
H
R
A
A
A
G
F
V
I
T
A
S
H
N
K
F
T
D
N
G
I
K
L
F
S
S
N
G
F
K
L
D
D
A
L
E
E
E
V
E
D
M
I
D
------------------
G
D
F
I
-
Y
Q
P
Q
F
K
F
G
S
Y
K
I
L
A
NA
I
D
E
Y
I
E
S
I
Y
S
RFAKF
V
---
N
Y
K
G
-
K
-----
V
V
V
D
C
A
H
G
A
A
S
H
N
F
E
A
L
L
D
K
F
G
I
N
Y
V
S
I
A
S
N
P
D
G
L
--
N
I
N
V
G
C
G
--
A
T
--
C
---
V
S
-------
N
I
K
K
---
A
V
K
E
Q
K
A
D
L
G
I
S
L
D
G
D
A
D
R
I
I
I
V
D
E
N
G
Q
E
I
D
G
D
G
I
L
N
I
L
A
Q
--
Y
S
D
I
C
G
G
T
N
G
I
V
G
T
Q
M
T
N
M
S
Y
E
N
H
Y
R
A
N
K
I
P
F
I
R
S
K
V
G
D
R
Y
V
L
E
D
L
V
K
Y
G
Y
K
I
G
G
E
S
S
G
H
V
I
N
L
N
-
F
-
G
T
T
G
D
G
L
F
T
A
I
Q
L
L
A
I
F
S
Q
A
D
K
P
V
S
E
F
---
K
L
Q
G
E
L
M
Q
-
Q
T
L
----
I
N
V
P
L
T
-
K
--
K
--
V
---
A
R
E
D
----
L
----
Q
--------
K
V
A
------
S
D
V
N
D
V
E
K
R
---------
L
G
N
R
-----------------
G
R
V
L
L
R
P
S
G
T
E
P
V
L
R
V
M
V
E
A
D
D
K
S
L
A
T
N
E
A
E
Y
L
V
E
K
V
K
Q
K
L
----
27
HHSearch
81.83
39%
-68
- C1 -
3I3W
1
GLMM_FRATT
A:
[3-443]
--
K
Y
F
G
T
D
G
I
R
G
-
E
V
A
N
S
T
I
T
V
E
F
T
Q
K
L
G
N
A
V
G
S
L
I
N
Q
K
N
--
Y
P
K
F
-
V
I
V
G
Q
D
T
R
S
S
G
G
F
L
K
F
A
L
V
S
G
L
N
A
A
G
I
D
V
L
D
L
G
V
V
P
T
P
V
V
A
F
M
T
V
K
H
R
A
A
A
G
F
V
I
T
A
S
H
N
K
F
T
D
N
G
I
K
L
F
S
S
N
G
F
K
L
D
D
A
L
E
E
E
V
E
D
M
I
D
G
-
D
---------
F
I
Y
Q
P
Q
F
K
F
G
-
S
Y
K
I
L
A
N
A
I
D
E
Y
I
E
-----
S
I
Y
S
R
F
A
-----
K
F--
V
N
Y
K
G
K
-----
V
V
V
D
C
A
H
G
A
A
S
H
N
F
E
A
L
L
D
K
F
G
I
N
Y
V
S
I
A
S
N
P
D
G
L
--
N
I
N
V
G
C
G
--
A
T
--
C
---
V
S
-------
N
I
K
K
---
A
V
K
E
Q
K
A
D
L
G
I
S
L
D
G
D
A
D
R
I
I
I
V
D
E
N
G
Q
E
I
D
G
D
G
I
L
N
I
L
A
Q
Y
S
D
I
C
G
--
G
T
N
G
I
V
G
T
Q
M
T
N
M
S
Y
E
N
H
Y
R
A
N
K
I
P
F
I
R
S
K
V
G
D
R
Y
V
L
E
D
L
V
K
Y
G
Y
K
I
G
G
E
S
S
G
H
V
I
N
L
N
-
F
-
G
T
T
G
D
G
L
F
T
A
I
Q
L
L
A
I
F
S
Q
A
D
K
P
V
S
E
F
---
K
L
Q
G
E
L
M
Q
-
Q
T
L
----
I
N
V
P
L
T
-
K
--
K
V
A
R
---
E
D
L
Q
------------------
K
V
A
------
S
D
V
N
D
V
E
K
R
---------
L
G
N
R
-----------------
G
R
V
L
L
R
P
S
G
T
E
P
V
L
R
V
M
V
E
A
D
D
K
S
L
A
T
N
E
A
E
Y
L
V
E
K
V
K
Q
K
L
V
---
24
PsiBlast_CBE
81.27
35%
-60
- C1 -
1WQA
1
?
B:
[1-442]
M
G
K
L
F
G
T
F
G
V
R
G
-
I
A
-
N
E
K
I
T
P
E
F
A
M
K
I
G
M
A
F
G
T
L
L
-
K
R
E
G
R
K
K
P
L
-
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
E
A
I
V
E
E
L
F
F
K
-
E
D
------
F
D
R
A
K
W
Y
E
I
G
E
V
-
R
R
E
D
I
I
---
K
P
Y
I
E
-----
A
I
K
S
K
V
D
-----
V
-----
E
A
I
K
KRKPF
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
Y
FP
A
R
N
P
E
P
N
--
E
E
--
N
---
L
K
-------
E
F
M
E
---
I
V
K
A
L
G
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
A
D
A
V
L
K
--
E
K
G
G
G
L
L
V
T
T
V
A
T
S
N
L
L
D
D
I
A
K
K
H
G
A
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
-
H
-
V
L
G
R
D
G
A
M
T
V
A
K
V
V
E
I
F
A
K
S
G
K
K
F
S
E
L
---
I
D
E
L
P
K
Y
Y
-
Q
----------
I
K
-
T
--
K
--
R
---
H
V
E
G
------------------
D
R
H
------
A
I
V
N
K
V
-
A
E
---------
M
A
R
E
RGYTVDTTDGAKIIFED
G
W
V
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
----------------
3
PsiBlast_PDB
80.79
35%
-59
- C1 -
1WQA
1
?
A:
[1-442]
M
G
K
L
F
G
T
F
G
V
R
G
-
I
A
-
N
E
K
I
T
P
E
F
A
M
K
I
G
M
A
F
G
T
L
L
-
K
R
E
G
R
K
K
P
L
-
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
E
A
I
V
E
E
L
F
F
K
-
E
D
------
F
D
R
A
K
W
Y
E
I
G
E
V
-
R
R
E
D
I
I
---
K
P
Y
I
E
-----
A
I
K
S
K
V
D
-----
V
-----
E
A
I
K
K
R
K
P
F
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
Y
FP
A
R
N
P
E
P
N
--
E
E
--
N
---
L
K
-------
E
F
M
E
---
I
V
K
A
L
G
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
A
D
A
V
L
K
--
E
K
G
G
G
L
L
V
T
T
V
A
T
S
N
L
L
D
D
I
A
K
K
H
G
A
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
-
H
-
V
L
G
R
D
G
A
M
T
V
A
K
V
V
E
I
F
A
K
S
G
K
K
F
S
E
L
---
I
D
E
L
P
K
Y
Y
-
Q
----------
I
K
-
T
--
K
--
R
---
H
V
E
G
------------------
D
R
H
------
A
I
V
N
K
V
-
A
E
---------
M
A
R
E
R
G
Y
T
V
D
TTD
G
A
K
I
I
F
ED
G
W
V
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
----------------
22
PsiBlast_CBE
80.59
35%
-60
- C1 -
1WQA
1
?
D:
[1-442]
M
G
K
L
F
G
T
F
G
V
R
G
-
I
A
-
N
E
K
I
T
P
E
F
A
M
K
I
G
M
A
F
G
T
L
L
-
K
R
E
G
R
K
K
P
L
-
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
E
A
I
V
E
E
L
F
F
K
-
E
D
------
F
D
R
A
K
W
Y
E
I
G
E
V
-
R
R
E
D
I
I
---
K
P
Y
I
E
-----
A
I
K
S
K
V
D
-----
V
-----
E
A
I
K
KRKPF
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
Y
FP
A
R
N
P
E
P
N
--
E
E
--
N
---
L
K
-------
E
F
M
E
---
I
V
K
A
L
G
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
A
D
A
V
L
K
--
E
K
G
G
G
L
L
V
T
T
V
A
T
S
N
L
L
D
D
I
A
K
K
H
G
A
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
-
H
-
V
L
G
R
D
G
A
M
T
V
A
K
V
V
E
I
F
A
K
S
G
K
K
F
S
E
L
---
I
D
E
L
P
K
Y
Y
-
Q
----------
I
K
-
T
--
K
--
R
---
H
V
E
G
------------------
D
R
H
------
A
I
V
N
K
V
-
A
E
---------
M
A
R
E
RGYTVDTTDGAKIIFED
G
W
V
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
----------------
23
PsiBlast_CBE
80.35
35%
-59
- C1 -
1WQA
1
?
C:
[1-442]
M
G
K
L
F
G
T
F
G
V
R
G
-
I
A
-
N
E
K
I
T
P
E
F
A
M
K
I
G
M
A
F
G
T
L
L
-
K
R
E
G
R
K
K
P
L
-
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
E
A
I
V
E
E
L
F
F
K
-
E
D
------
F
D
R
A
K
W
Y
E
I
G
E
V
-
R
R
E
D
I
I
---
K
P
Y
I
E
-----
A
I
K
S
K
V
D
-----
V
-----
E
A
I
K
KRKPF
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
Y
FP
A
R
N
P
E
P
N
--
E
E
--
N
---
L
K
-------
E
F
M
E
---
I
V
K
A
L
G
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
A
D
A
V
L
K
--
E
K
G
G
G
L
L
V
T
T
V
A
T
S
N
L
L
D
D
I
A
K
K
H
G
A
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
-
H
-
V
L
G
R
D
G
A
M
T
V
A
K
V
V
E
I
F
A
K
S
G
K
K
F
S
E
L
---
I
D
E
L
P
K
Y
Y
-
Q
----------
I
K
-
T
--
K
--
R
---
H
V
E
G
------------------
D
R
H
------
A
I
V
N
K
V
-
A
E
---------
M
A
R
E
RGYTVDTTDGAKIIFED
G
W
V
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
----------------
28
HHSearch
79.71
34%
-59
* C1 *
1WQA
1
?
A:
[1-454]
M
G
K
L
F
G
T
F
G
V
R
G
-
I
A
-
N
E
K
I
T
P
E
F
A
M
K
I
G
M
A
F
G
T
L
L
K
R
E
G
-
R
K
K
P
L
-
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
E
A
I
V
E
E
L
F
F
K
-
E
D
--------
F
D
R
A
K
W
Y
E
I
G
-
E
V
R
R
E
-
D
I
I
K
P
Y
I
E
-----
A
I
K
S
K
V
D
-----
V
E
A
I
K
K
R
K
P
F
-----
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
Y
--
F
P
A
R
N
P
E
PN
E
E
--
N
---
L
K
-------
E
F
M
E
---
I
V
K
A
L
G
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
A
D
A
V
L
K
E
K
--
G
G
G
L
L
V
T
T
V
A
T
S
N
L
L
D
D
I
A
K
K
H
G
A
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
-
H
-
V
L
G
R
D
G
A
M
T
V
A
K
V
V
E
I
F
A
K
S
G
K
K
F
S
E
L
---
I
D
E
L
P
K
Y
Y
-
Q
I
K
----
T
K
R
H
V
E
G
D
--
R
--
H
---
A
I
V
N
K
V
A
E
M
----
A
R
E
R
G----
Y
T
V
------
D
T
T
D
G
A
K
I
I
---------
F
-
E
D
-----------------
G
W
V
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
L
N
L
G
I
E
L
L
E
K
A
L
----
4
PsiBlast_PDB
77.21
29%
-63
- C1 -
2F7L
1
?
A:
[1-455]
M
G
K
L
F
G
T
D
G
V
R
G
-
I
V
-
N
K
E
L
T
P
E
L
V
L
K
L
S
K
A
I
G
T
F
F
G
K
N
S
-----
K
-
I
L
V
G
R
D
V
R
A
G
G
D
M
L
V
K
I
V
E
G
G
L
L
S
V
G
V
E
V
Y
D
G
G
M
A
P
T
P
A
L
Q
Y
A
V
K
T
L
G
Y
D
G
G
V
V
I
T
A
S
H
N
P
A
P
Y
N
G
I
K
V
V
D
K
D
G
I
E
I
R
R
E
K
E
N
E
I
E
D
L
F
F
T
-
E
R
FNTIEW
S
S
L
T
T
E
V
K
R
E
D
R
-
V
I
S
T
Y
V
N
G
I
L
S
H
V
D
-----
I
E
K
---------
I
---
K
K
K
N
Y
K
-----
V
L
I
D
P
A
N
S
V
G
A
L
S
T
P
L
V
A
R
A
L
G
C
K
I
Y
T
I
N
G
-------
N
L
D
P
L
F
S
--
A
R
--
Q
---
P
E
PTFDSL
K
E
T
A
E
---
V
V
K
T
L
K
V
D
L
G
V
A
H
D
G
D
A
D
R
A
I
F
I
D
S
E
G
R
V
Q
W
G
D
R
S
G
T
L
L
S
Y
W
A
S
V
K
N
P
K
A
I
K
K
I
V
T
A
V
S
S
S
S
L
V
E
E
Y
L
S
K
Y
N
I
Q
V
D
W
T
K
V
G
S
V
D
I
A
H
K
V
A
D
E
N
A
L
A
G
F
E
E
N
G
G
F
M
Y
P
P
-
H
-
Q
Y
V
R
D
G
A
M
S
F
A
L
M
L
E
L
L
A
N
E
N
V
S
S
A
E
L
---
F
D
R
L
P
K
Y
Y
-
L
V
K
----
T
K
V
D
L
K
-
P
--
G
--
L
---
M
V
E
E
----
I
----
Y
K
-------
K
I
L
------
E
V
Y
S
T
S
S
V
K
A
I
TIDG
V
K
I
I
G
K
D
-----------------
F
W
F
L
V
R
K
S
G
T
E
P
I
I
R
I
M
A
E
A
K
D
E
N
V
A
N
N
L
V
N
E
L
K
K
I
V
E
G
K
-----
26
HHSearch
76.28
30%
-63
- C1 -
2F7L
1
?
A:
[1-454]
M
G
K
L
F
G
T
D
G
V
R
G
-
I
V
-
N
K
E
L
T
P
E
L
V
L
K
L
S
K
A
I
G
T
F
F
G
K
N
-----
S
K
-
I
L
V
G
R
D
V
R
A
G
G
D
M
L
V
K
I
V
E
G
G
L
L
S
V
G
V
E
V
Y
D
G
G
M
A
P
T
P
A
L
Q
Y
A
V
K
T
L
G
Y
D
G
G
V
V
I
T
A
S
H
N
P
A
P
Y
N
G
I
K
V
V
D
K
D
G
I
E
I
R
R
E
K
E
N
E
I
E
D
L
F
F
T
-
E
R
--------
F
N
T
I
E
W
S
S
L
T
T
E
V
K
R
E
D
R
V
I
S
T
Y
V
N
-----
G
I
L
S
H
V
D
-----
I
E
K
I
K
K
K
N
Y
K
-----
V
L
I
D
P
A
N
S
V
G
A
L
S
T
P
L
V
A
R
A
L
G
C
K
I
Y
T
I
N
G
N
L
D
P
L
--
F
S
A
R
Q
P
E
--
P
T
FD
S
---
L
K
-------
E
T
A
E
---
V
V
K
T
L
K
V
D
L
G
V
A
H
D
G
D
A
D
R
A
I
F
I
D
S
E
G
R
V
Q
W
G
D
R
S
G
T
L
L
S
Y
W
A
S
V
K
N
P
K
A
I
K
K
I
V
T
A
V
S
S
S
S
L
V
E
E
Y
L
S
K
Y
N
I
Q
V
D
W
T
K
V
G
S
V
D
I
A
H
K
V
A
D
E
N
A
L
A
G
F
E
E
N
G
G
F
M
Y
P
P
-
H
-
Q
Y
V
R
D
G
A
M
S
F
A
L
M
L
E
L
L
A
N
E
N
V
S
S
A
E
L
---
F
D
R
L
P
K
Y
Y
-
L
V
K
----
T
K
V
D
L
K
-
P
--
G
--
L
M
V
E
E
I
Y
K
----
K
I
L
E
V
Y
STSS----
V
K
A
------
I
T
I
D
G
V
K
I
I
---------
G
-
K
D
-----------------
F
W
F
L
V
R
K
S
G
T
E
P
I
I
R
I
M
A
E
A
K
D
E
N
V
A
N
N
L
V
N
E
L
K
K
I
V
E
G
------
30
HHSearch
73.76
26%
-58
- C1 -
1P5D
2
ALGC_PSEAE
X:
[10-457]
P
A
S
I
F
R
A
Y
D
I
R
G
-
V
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
G
---
E
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
-
N
D
--------
L
A
----
S
G
V
G
-
S
V
E
Q
-
V
D
I
L
P
R
Y
F
K
-----
Q
I
R
D
D
I
A
---------
M
A
K
P
M
K
-----
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
--
F
P
N
H
H
P
D
--
P
G
--
K
PEN
L
K
-------
D
L
I
A
---
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
--
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
-
R
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
---
F
S
A
F
P
S
D
I
S
T
P
E
----
I
N
I
T
V
T
-
E
DS
K
--
F
---
A
I
I
E
----
A
----
L
QRDAQWGE
G
N
I
------
T
T
L
D
G
V
R
V
D
---------
Y
-
P
K
-----------------
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
T
V
F
R
N
Q
L
K
A
V
D
S
---
8
PsiBlast_PDB
72.27
27%
-52
- C1 -
2H4L
2
ALGC_PSEAE
X:
[19-444]
---------
I
R
G
-
V
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
---
S
E
S
L
A
R
G
E
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
---
I
Q
A
L
R
E
R
I
E
K
------
N
D
L
A
S
G
V
G
S
--
V
-
E
Q
V
D
I
L
P
---
R
Y
F
K
-----
Q
I
R
D
D
I
A
-----
M
---
A
-
K
P
M
K
-----
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
--
F
P
N
H
H
P
D
--
P
G
--
K
---
P
E
-------
N
L
K
D
LIA
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
--
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
-
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
------
F
S
A
F
P
-
S
D
I
STPE
I
N
I
T
V
T
-
E
DS
K
--
F
---
A
I
I
E
----
A
----
L
QR------
D
A
Q
WGEGNI
T
T
L
D
G
V
R
V
D
---------
Y
P
-
K
-----------------
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
----------------
13
PsiBlast_PDB
72.17
27%
-56
- C1 -
1PCM
2
ALGC_PSEAE
X:
[19-444]
---------
I
R
G
-
V
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
---
S
E
S
L
A
R
G
E
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
---
I
Q
A
L
R
E
R
I
E
K
------
N
D
L
A
S
G
V
G
S
--
V
-
E
Q
V
D
I
L
P
---
R
Y
F
K
-----
Q
I
R
D
D
I
A
-----
M
---
A
-
K
P
M
K
-----
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
--
F
P
N
H
H
P
D
--
P
G
--
K
---
P
E
-------
N
L
K
D
LIA
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
--
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
-
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
------
F
S
A
F
P
-
S
D
I
STPE
I
N
I
T
V
T
-
E
DS
K
--
F
---
A
I
I
E
----
A
----
L
QR------
D
A
Q
WGEGNI
T
T
L
D
G
V
R
V
D
---------
Y
P
-
K
-----------------
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
----------------
9
PsiBlast_PDB
71.99
27%
-53
- C1 -
2H5A
2
ALGC_PSEAE
X:
[19-444]
---------
I
R
G
-
V
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
---
S
E
S
L
A
R
G
E
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
---
I
Q
A
L
R
E
R
I
E
K
------
N
D
L
A
S
G
V
G
S
--
V
-
E
Q
V
D
I
L
P
---
R
Y
F
K
-----
Q
I
R
D
D
I
A
-----
M
---
A
-
K
P
M
K
-----
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
--
F
P
N
H
H
P
D
--
P
G
--
K
---
P
E
-------
N
L
K
D
LIA
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
--
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
-
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
------
F
S
A
F
P
-
S
D
I
STPE
I
N
I
T
V
T
-
E
DS
K
--
F
---
A
I
I
E
----
A
----
L
QR------
D
A
Q
WGEGNI
T
T
L
D
G
V
R
V
D
---------
Y
P
-
K
-----------------
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
----------------
6
PsiBlast_PDB
71.74
28%
-54
- C1 -
4MRQ
13
ALGC_PSEAE
A:
[11-436]
---------
I
R
G
-
V
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
---
S
E
S
L
A
R
G
E
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
---
I
Q
A
L
R
E
R
I
E
K
------
N
D
L
A
S
G
V
G
S
--
V
-
E
Q
V
D
I
L
P
---
R
Y
F
K
-----
Q
I
R
D
D
I
A
-----
M
---
A
-
K
P
M
K
-----
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
--
F
P
N
H
H
P
D
--
P
G
--
K
---
P
E
-------
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
--
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
-
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
------
F
S
A
F
P
-
S
D
I
STP
E
I
N
I
T
V
T
-
E
DS
K
--
F
---
A
I
I
E
----
A
----
L
Q
R
------
D
A
Q
WGEGNI
T
T
L
D
G
V
R
V
D
---------
Y
P
-
K
-----------------
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
----------------
11
PsiBlast_PDB
71.64
27%
-55
- C1 -
1P5G
2
ALGC_PSEAE
X:
[19-444]
---------
I
R
G
-
V
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
---
S
E
S
L
A
R
G
E
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
---
I
Q
A
L
R
E
R
I
E
K
------
N
D
L
A
S
G
V
G
S
--
V
-
E
Q
V
D
I
L
P
---
R
Y
F
K
-----
Q
I
R
D
D
I
A
-----
M
---
A
-
K
P
M
K
-----
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
--
F
P
N
H
H
P
D
--
P
G
--
K
---
P
E
-------
N
L
K
D
LIA
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
--
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
-
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
------
F
S
A
F
P
-
S
D
I
STPE
I
N
I
T
V
T
-
E
DS
K
--
F
---
A
I
I
E
----
A
----
L
QR------
D
A
Q
WGEGNI
T
T
L
D
G
V
R
V
D
---------
Y
P
-
K
-----------------
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
----------------
16
PsiBlast_PDB
71.60
28%
-53
- C1 -
3BKQ
2
ALGC_PSEAE
X:
[19-444]
---------
I
R
G
-
V
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
---
S
E
S
L
A
R
G
E
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
---
I
Q
A
L
R
E
R
I
E
K
------
N
D
L
A
S
G
V
G
S
--
V
-
E
Q
V
D
I
L
P
---
R
Y
F
K
-----
Q
I
R
D
D
I
A
-----
M
---
A
-
K
P
M
K
-----
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
--
F
P
N
H
H
P
D
--
P
G
--
K
---
P
E
-------
N
L
K
D
LIA
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
--
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
-
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
FSA
F
G
S
D
I
S
T
P
-
E
------
I
N
I
T
V
T
-
E
DS
K
--
F
---
A
I
I
E
----
A
----
L
QR------
D
A
Q
WGEGNI
T
T
L
D
G
V
R
V
D
---------
Y
P
-
K
-----------------
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
----------------
7
PsiBlast_PDB
71.52
27%
-55
- C1 -
1K2Y
2
ALGC_PSEAE
X:
[19-444]
---------
I
R
G
-
V
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
---
S
E
S
L
A
R
G
E
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
A
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
---
I
Q
A
L
R
E
R
I
E
K
------
N
D
L
A
S
G
V
G
S
--
V
-
E
Q
V
D
I
L
P
---
R
Y
F
K
-----
Q
I
R
D
D
I
A
-----
M
---
A
-
K
P
M
K
-----
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
--
F
P
N
H
H
P
D
--
P
G
--
K
---
P
E
-------
N
L
K
D
LIA
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
--
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
-
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
------
F
S
A
F
P
-
S
D
I
STPE
I
N
I
T
V
T
-
E
DS
K
--
F
---
A
I
I
E
----
A
----
L
QR------
D
A
Q
WGEGNI
T
T
L
D
G
V
R
V
D
---------
Y
P
-
K
-----------------
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
----------------