@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1968: (2016-03-30 )
MTKTKAIDIIGAPSTFGQRKLGVDLGPTAIRYAGLISRLKQLDLDVYDKGDIKVPAVNIEKFHSEQKGLRNYDEIIDVNQKLNKEVSASIENNRFPLVLGGDHSIAVGSVSAISKHYNNLGVIWYDAHGDLNIPEESPSGNIHGMPLRILTGEGPKELLELNSNVIKPENIVLIGMRDLDKGERQFIKDHNIKTFTMSDIDKLGIKEVIENTIEYLKSRNVDGVHLSLDVDALDPLETPGTGTRVLGGLSYRESHFALELLHQSHLISSMDLVEVNPLIDSNNHTAEQAVSLVGTFFGETLL
Atome Classification :
(64 SA)
.........10........20........30........40........50..-......60....-....70........80........90........100.......110.......120.......130.......140....----...150....-...160-.-----.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280----..---------------.....290.......300
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTK
T
K
A
I
D
I
IGAPSTFGQ
R
K
LGVDLG
P
T
A
I
R
Y
A
G
L
I
S
R
L
K
QLDLDVYDKGDIK-VPA
V
N
I
E
K
F
H
S
E
-
Q
KGLR
N
Y
D
E
I
I
D
V
N
Q
K
L
N
K
E
V
S
ASIENN
R
F
P
L
V
LGGDH
S
I
AV
G
S
V
S
A
I
S
K
H
YNN
L
G
V
I
W
Y
DAHGDLNIPEESPSGNIH
G
M
P
----
L
R
I
LTGE
G
P
K
-
E
L
L
E
L--N-----SNVIKPE
N
I
V
L
I
GMRDLDK
G
E
R
Q
F
I
K
DHN
I
K
T
F
T
M
S
D
I
D
K
L
G
I
K
E
V
I
E
N
T
I
E
Y
L
K
SRNV
D
G
V
H
L
S
L
DVDALDPLETPGTGT
R
V
L
GGLSY
R
E
S
H
F
A
L
E
L
L
H
Q
S
H
LISSM
D
L
V
E
V
NPLIDSN----N
H
---------------
T
A
E
Q
A
V
S
L
V
G
T
F
FGETLL
44
PsiBlast_CBE
98.60
52%
-77
- C9 -
1CEV
2
ARGI_BACCD
C:
[2-299]
----
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
Y
D
I
E
D
L
G
D
I
---
P
I
G
K
A
E
R
L
H
E
Q
G
D
S
R
L
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
----
L
A
A
S
L
G
F
G
H
P
-
A
L
T
Q
I
--
G
GY---
S
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
K
E
R
T
-
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
D
E
R
----
N
K
---------------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
43
PsiBlast_CBE
98.35
52%
-77
- C9 -
1CEV
2
ARGI_BACCD
D:
[2-299]
----
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
Y
D
I
E
D
L
G
D
I
---
P
I
G
K
A
E
R
L
H
E
Q
G
D
S
R
L
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
----
L
A
A
S
L
G
F
G
H
P
-
A
L
T
Q
I
--
G
GY---
S
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
K
E
R
T
-
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
D
E
R
----
N
K
---------------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
45
PsiBlast_CBE
98.34
52%
-77
- C9 -
1CEV
2
ARGI_BACCD
B:
[2-299]
----
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
Y
D
I
E
D
L
G
D
I
---
P
I
G
K
A
E
R
L
H
E
Q
G
D
S
R
L
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
----
L
A
A
S
L
G
F
G
H
P
-
A
L
T
Q
I
--
G
GY---
S
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
K
E
R
T
-
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
D
E
R
----
N
K
---------------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
42
PsiBlast_CBE
98.15
52%
-77
- C9 -
1CEV
2
ARGI_BACCD
E:
[2-299]
----
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
Y
D
I
E
D
L
G
D
I
---
P
I
G
K
A
E
R
L
H
E
Q
G
D
S
R
L
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
----
L
A
A
S
L
G
F
G
H
P
-
A
L
T
Q
I
--
G
GY---
S
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
K
E
R
T
-
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
D
E
R
----
N
K
---------------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
41
PsiBlast_CBE
98.12
52%
-78
- C9 -
1CEV
2
ARGI_BACCD
F:
[2-299]
----
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
Y
D
I
E
D
L
G
D
I
---
P
I
G
K
A
E
R
L
H
E
Q
G
D
S
R
L
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
----
L
A
A
S
L
G
F
G
H
P
-
A
L
T
Q
I
--
G
GY---
S
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
K
E
R
T
-
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
D
E
R
----
N
K
---------------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
1
PsiBlast_PDB
97.81
52%
-75
- C9 -
1CEV
2
ARGI_BACCD
A:
[2-299]
----
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
Y
D
I
E
D
L
G
D
I
---
P
I
G
K
A
E
R
L
H
E
Q
G
D
S
R
L
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
----
L
A
A
S
L
G
F
G
H
P
-
A
L
T
Q
I
--
G
GY---
S
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
K
E
R
T
-
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
D
E
R
----
N
K
---------------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
37
PsiBlast_CBE
97.75
52%
-74
- C9 -
2CEV
3
ARGI_BACCD
E:
[2-299]
----
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
Y
D
I
E
D
L
G
D
I
---
P
I
G
K
A
E
R
L
H
E
Q
G
D
S
R
L
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
----
L
A
A
S
L
G
F
G
H
P
-
A
L
T
Q
I
--
G
GY---
S
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
K
E
R
T
-
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
D
E
R
----
N
K
---------------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
33
PsiBlast_CBE
97.69
52%
-72
- C9 -
3CEV
4
ARGI_BACCD
D:
[2-299]
----
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
Y
D
I
E
D
L
G
D
I
---
P
I
G
K
A
E
R
L
H
E
Q
G
D
S
R
L
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
----
L
A
A
S
L
G
F
G
H
P
-
A
L
T
Q
I
--
G
GY---
S
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
K
E
R
T
-
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
D
E
R
----
N
K
---------------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
21
PsiBlast_CBE
97.51
52%
-74
- C9 -
5CEV
4
ARGI_BACCD
F:
[2-299]
----
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
Y
D
I
E
D
L
G
D
I
---
P
I
G
K
A
E
R
L
H
E
Q
G
D
S
R
L
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
----
L
A
A
S
L
G
F
G
H
P
-
A
L
T
Q
I
--
G
GY---
S
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
K
E
R
T
-
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
D
E
R
----
N
K
---------------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
34
PsiBlast_CBE
97.46
52%
-71
- C9 -
3CEV
4
ARGI_BACCD
C:
[2-299]
----
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
Y
D
I
E
D
L
G
D
I
---
P
I
G
K
A
E
R
L
H
E
Q
G
D
S
R
L
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
----
L
A
A
S
L
G
F
G
H
P
-
A
L
T
Q
I
--
G
GY---
S
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
K
E
R
T
-
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
D
E
R
----
N
K
---------------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
28
PsiBlast_CBE
97.42
52%
-74
- C9 -
4CEV
4
ARGI_BACCD
D:
[2-299]
----
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
Y
D
I
E
D
L
G
D
I
---
P
I
G
K
A
E
R
L
H
E
Q
G
D
S
R
L
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
----
L
A
A
S
L
G
F
G
H
P
-
A
L
T
Q
I
--
G
GY---
S
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
K
E
R
T
-
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
D
E
R
----
N
K
---------------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
35
PsiBlast_CBE
97.35
52%
-73
- C9 -
3CEV
4
ARGI_BACCD
B:
[2-299]
----
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
Y
D
I
E
D
L
G
D
I
---
P
I
G
K
A
E
R
L
H
E
Q
G
D
S
R
L
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
----
L
A
A
S
L
G
F
G
H
P
-
A
L
T
Q
I
--
G
GY---
S
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
K
E
R
T
-
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
D
E
R
----
N
K
---------------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
23
PsiBlast_CBE
97.32
52%
-73
- C9 -
5CEV
4
ARGI_BACCD
D:
[2-299]
----
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
Y
D
I
E
D
L
G
D
I
---
P
I
G
K
A
E
R
L
H
E
Q
G
D
S
R
L
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
----
L
A
A
S
L
G
F
G
H
P
-
A
L
T
Q
I
--
G
GY---
S
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
K
E
R
T
-
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
D
E
R
----
N
K
---------------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
24
PsiBlast_CBE
97.24
52%
-73
- C9 -
5CEV
4
ARGI_BACCD
C:
[2-299]
----
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
Y
D
I
E
D
L
G
D
I
---
P
I
G
K
A
E
R
L
H
E
Q
G
D
S
R
L
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
----
L
A
A
S
L
G
F
G
H
P
-
A
L
T
Q
I
--
G
GY---
S
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
K
E
R
T
-
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
D
E
R
----
N
K
---------------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
22
PsiBlast_CBE
97.23
52%
-75
- C9 -
5CEV
4
ARGI_BACCD
E:
[2-299]
----
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
Y
D
I
E
D
L
G
D
I
---
P
I
G
K
A
E
R
L
H
E
Q
G
D
S
R
L
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
----
L
A
A
S
L
G
F
G
H
P
-
A
L
T
Q
I
--
G
GY---
S
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
K
E
R
T
-
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
D
E
R
----
N
K
---------------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
29
PsiBlast_CBE
97.14
52%
-73
- C9 -
4CEV
4
ARGI_BACCD
C:
[2-299]
----
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
Y
D
I
E
D
L
G
D
I
---
P
I
G
K
A
E
R
L
H
E
Q
G
D
S
R
L
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
----
L
A
A
S
L
G
F
G
H
P
-
A
L
T
Q
I
--
G
GY---
S
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
K
E
R
T
-
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
D
E
R
----
N
K
---------------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
30
PsiBlast_CBE
97.13
52%
-74
- C9 -
4CEV
5
ARGI_BACCD
B:
[2-299]
----
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
Y
D
I
E
D
L
G
D
I
---
P
I
G
K
A
E
R
L
H
E
Q
G
D
S
R
L
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
----
L
A
A
S
L
G
F
G
H
P
-
A
L
T
Q
I
--
G
GY---
S
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
K
E
R
T
-
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
D
E
R
----
N
K
---------------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
38
PsiBlast_CBE
97.01
52%
-72
- C9 -
2CEV
3
ARGI_BACCD
D:
[2-299]
----
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
Y
D
I
E
D
L
G
D
I
---
P
I
G
K
A
E
R
L
H
E
Q
G
D
S
R
L
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
----
L
A
A
S
L
G
F
G
H
P
-
A
L
T
Q
I
--
G
GY---
S
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
K
E
R
T
-
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
D
E
R
----
N
K
---------------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
27
PsiBlast_CBE
97.00
52%
-74
- C9 -
4CEV
4
ARGI_BACCD
E:
[2-299]
----
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
Y
D
I
E
D
L
G
D
I
---
P
I
G
K
A
E
R
L
H
E
Q
G
D
S
R
L
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
----
L
A
A
S
L
G
F
G
H
P
-
A
L
T
Q
I
--
G
GY---
S
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
K
E
R
T
-
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
D
E
R
----
N
K
---------------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
40
PsiBlast_CBE
96.98
52%
-73
- C9 -
2CEV
4
ARGI_BACCD
B:
[2-299]
----
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
Y
D
I
E
D
L
G
D
I
---
P
I
G
K
A
E
R
L
H
E
Q
G
D
S
R
L
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
----
L
A
A
S
L
G
F
G
H
P
-
A
L
T
Q
I
--
G
GY---
S
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
K
E
R
T
-
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
D
E
R
----
N
K
---------------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
112
HHSearch
89.29
36%
-73
- C9 -
3SL1
3
?
A:
[24-412]
----
K
N
V
S
I
I
G
S
P
L
A
A
G
Q
P
L
G
G
V
Q
L
A
C
D
D
L
R
K
L
G
L
H
N
V
I
D
V
L
G
W
K
Y
E
D
I
G
N
I
D
-
N
---------
C
Y
-
Y
D
N
I
R
N
I
K
E
I
G
I
F
S
K
N
L
F
D
T
M
S
N
E
L
R
K
K
N
F
V
L
N
I
G
G
D
H
G
V
A
F
S
S
I
L
S
S
L
Q
M
Y
Q
N
L
R
V
I
W
I
D
A
H
G
D
I
N
I
P
E
T
S
P
S
G
N
Y
H
G
M
T
----
L
A
H
T
L
G
L
F
K
K
-
K
V
P
Y
F
EW
S
EN---
L
T
Y
L
K
P
E
N
T
A
I
I
G
I
R
D
I
D
A
Y
E
K
I
I
L
K
K
C
N
I
N
Y
Y
T
I
F
D
I
E
K
N
G
I
Y
N
T
I
C
T
A
L
E
K
I
D
P
N
S
N
C
P
I
H
I
S
L
D
I
D
S
V
D
N
V
F
A
P
G
T
G
T
V
A
K
G
G
L
N
Y
R
E
I
N
L
L
M
K
I
L
A
E
T
K
R
V
V
S
M
D
L
V
E
Y
N
P
S
L
D
E
V
----
D
K
KVHGDSLPILDNAT
K
T
G
K
L
C
L
E
L
I
A
R
V
L
G
Y
D
I
-
53
PsiBlast_CBE
89.09
41%
-73
- C9 -
3E9B
3
ARGI1_RAT
C:
[6-305]
----
K
P
I
E
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
K
G
P
A
A
L
R
K
A
G
L
V
E
K
L
K
E
T
E
Y
N
V
R
D
H
G
D
L
A
F
V
D
V
P
N
D
S
P
F
Q
I
-----
V
K
N
P
R
S
V
G
K
A
N
E
Q
L
A
A
V
V
A
E
T
Q
K
N
G
T
I
S
V
V
L
G
G
D
H
S
M
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
C
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
A
S
S
G
N
L
H
G
Q
P
VAFL
L
K
E
L
K
G
K
F
P
D
V
P
G
F
S
W
--
V
-----
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
I
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
K
L
G
I
G
K
V
M
E
E
T
F
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
V
F
T
P
A
T
G
T
P
V
V
G
G
L
S
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
T
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
L
T
L
S
C
F
G
----
11
PsiBlast_PDB
88.93
41%
-74
- C9 -
3E9B
3
ARGI1_RAT
A:
[6-305]
----
K
P
I
E
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
K
G
P
A
A
L
R
K
A
G
L
V
E
K
L
K
E
T
E
Y
N
V
R
D
H
G
D
L
A
F
V
D
V
P
N
D
S
P
F
Q
I
-----
V
K
N
P
R
S
V
G
K
A
N
E
Q
L
A
A
V
V
A
E
T
Q
K
N
G
T
I
S
V
V
L
G
G
D
H
S
M
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
C
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
A
S
S
G
N
L
H
G
Q
P
V
A
F
L
L
K
E
L
K
G
K
F
P
D
V
P
G
F
S
W
--
V
-----
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
I
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
K
L
G
I
G
K
V
M
E
E
T
F
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
V
F
T
P
A
T
G
T
P
V
V
G
G
L
S
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
T
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
L
T
L
S
C
F
G
----
65
PsiBlast_CBE
88.82
41%
-75
- C9 -
1HQ5
3
ARGI1_RAT
B:
[6-305]
----
K
P
I
E
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
K
G
P
A
A
L
R
K
A
G
L
V
E
K
L
K
E
T
E
Y
N
V
R
D
H
G
D
L
A
F
V
D
V
P
N
D
S
P
F
Q
I
-----
V
K
N
P
R
S
V
G
K
A
N
E
Q
L
A
A
V
V
A
E
T
Q
K
N
G
T
I
S
V
V
L
G
G
D
H
S
M
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
C
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
S
S
G
N
L
H
G
Q
P
VAFL
L
K
E
L
K
G
K
F
P
D
V
P
G
F
S
W
--
V
-----
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
I
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
K
L
G
I
G
K
V
M
E
E
T
F
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
V
F
T
P
A
T
G
T
P
V
V
G
G
L
S
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
T
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
L
T
L
S
C
F
G
----
12
PsiBlast_PDB
88.82
41%
-74
- C9 -
1D3V
3
ARGI1_RAT
A:
[6-305]
----
K
P
I
E
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
K
G
P
A
A
L
R
K
A
G
L
V
E
K
L
K
E
T
E
Y
N
V
R
D
H
G
D
L
A
F
V
D
V
P
N
D
S
P
F
Q
I
-----
V
K
N
P
R
S
V
G
K
A
N
E
Q
L
A
A
V
V
A
E
T
Q
K
N
G
T
I
S
V
V
L
G
G
D
H
S
M
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
C
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
S
S
G
N
L
H
G
Q
P
V
A
F
L
L
K
E
L
K
G
K
F
P
D
V
P
G
F
S
W
--
V
-----
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
I
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
K
L
G
I
G
K
V
M
E
E
T
F
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
V
F
T
P
A
T
G
T
P
V
V
G
G
L
S
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
T
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
L
T
L
S
C
F
G
----
66
PsiBlast_CBE
88.72
41%
-75
- C9 -
1D3V
3
ARGI1_RAT
B:
[6-305]
----
K
P
I
E
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
K
G
P
A
A
L
R
K
A
G
L
V
E
K
L
K
E
T
E
Y
N
V
R
D
H
G
D
L
A
F
V
D
V
P
N
D
S
P
F
Q
I
-----
V
K
N
P
R
S
V
G
K
A
N
E
Q
L
A
A
V
V
A
E
T
Q
K
N
G
T
I
S
V
V
L
G
G
D
H
S
M
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
C
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
S
S
G
N
L
H
G
Q
P
VAFL
L
K
E
L
K
G
K
F
P
D
V
P
G
F
S
W
--
V
-----
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
I
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
K
L
G
I
G
K
V
M
E
E
T
F
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
V
F
T
P
A
T
G
T
P
V
V
G
G
L
S
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
T
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
L
T
L
S
C
F
G
----
16
PsiBlast_PDB
88.62
41%
-73
- C9 -
1R1O
3
ARGI1_RAT
A:
[6-305]
----
K
P
I
E
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
K
G
P
A
A
L
R
K
A
G
L
V
E
K
L
K
E
T
E
Y
N
V
R
D
H
G
D
L
A
F
V
D
V
P
N
D
S
P
F
Q
I
-----
V
K
N
P
R
S
V
G
K
A
N
E
Q
L
A
A
V
V
A
E
T
Q
K
N
G
T
I
S
V
V
L
G
G
D
H
S
M
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
C
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
S
S
G
N
L
H
G
Q
P
V
A
F
L
L
K
E
L
K
G
K
F
P
D
V
P
G
F
S
W
--
V
-----
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
I
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
K
L
G
I
G
K
V
M
E
E
T
F
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
V
F
T
P
A
T
G
T
P
V
V
G
G
L
S
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
T
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
L
T
L
S
C
F
G
----
54
PsiBlast_CBE
88.50
41%
-74
- C9 -
3E9B
3
ARGI1_RAT
B:
[6-305]
----
K
P
I
E
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
K
G
P
A
A
L
R
K
A
G
L
V
E
K
L
K
E
T
E
Y
N
V
R
D
H
G
D
L
A
F
V
D
V
P
N
D
S
P
F
Q
I
-----
V
K
N
P
R
S
V
G
K
A
N
E
Q
L
A
A
V
V
A
E
T
Q
K
N
G
T
I
S
V
V
L
G
G
D
H
S
M
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
C
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
A
S
S
G
N
L
H
G
Q
P
VAFL
L
K
E
L
K
G
K
F
P
D
V
P
G
F
S
W
--
V
-----
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
I
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
K
L
G
I
G
K
V
M
E
E
T
F
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
V
F
T
P
A
T
G
T
P
V
V
G
G
L
S
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
T
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
L
T
L
S
C
F
G
----
59
PsiBlast_CBE
88.38
41%
-74
- C9 -
1R1O
3
ARGI1_RAT
C:
[6-305]
----
K
P
I
E
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
K
G
P
A
A
L
R
K
A
G
L
V
E
K
L
K
E
T
E
Y
N
V
R
D
H
G
D
L
A
F
V
D
V
P
N
D
S
P
F
Q
I
-----
V
K
N
P
R
S
V
G
K
A
N
E
Q
L
A
A
V
V
A
E
T
Q
K
N
G
T
I
S
V
V
L
G
G
D
H
S
M
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
C
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
S
S
G
N
L
H
G
Q
P
VAFL
L
K
E
L
K
G
K
F
P
D
V
P
G
F
S
W
--
V
-----
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
I
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
K
L
G
I
G
K
V
M
E
E
T
F
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
V
F
T
P
A
T
G
T
P
V
V
G
G
L
S
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
T
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
L
T
L
S
C
F
G
----
13
PsiBlast_PDB
88.32
41%
-73
- C9 -
1HQ5
3
ARGI1_RAT
A:
[6-305]
----
K
P
I
E
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
K
G
P
A
A
L
R
K
A
G
L
V
E
K
L
K
E
T
E
Y
N
V
R
D
H
G
D
L
A
F
V
D
V
P
N
D
S
P
F
Q
I
-----
V
K
N
P
R
S
V
G
K
A
N
E
Q
L
A
A
V
V
A
E
T
Q
K
N
G
T
I
S
V
V
L
G
G
D
H
S
M
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
C
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
S
S
G
N
L
H
G
Q
P
V
A
F
L
L
K
E
L
K
G
K
F
P
D
V
P
G
F
S
W
--
V
-----
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
I
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
K
L
G
I
G
K
V
M
E
E
T
F
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
V
F
T
P
A
T
G
T
P
V
V
G
G
L
S
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
T
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
L
T
L
S
C
F
G
----
60
PsiBlast_CBE
88.30
41%
-73
- C9 -
1R1O
3
ARGI1_RAT
B:
[6-305]
----
K
P
I
E
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
K
G
P
A
A
L
R
K
A
G
L
V
E
K
L
K
E
T
E
Y
N
V
R
D
H
G
D
L
A
F
V
D
V
P
N
D
S
P
F
Q
I
-----
V
K
N
P
R
S
V
G
K
A
N
E
Q
L
A
A
V
V
A
E
T
Q
K
N
G
T
I
S
V
V
L
G
G
D
H
S
M
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
C
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
S
S
G
N
L
H
G
Q
P
VAFL
L
K
E
L
K
G
K
F
P
D
V
P
G
F
S
W
--
V
-----
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
I
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
K
L
G
I
G
K
V
M
E
E
T
F
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
V
F
T
P
A
T
G
T
P
V
V
G
G
L
S
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
T
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
L
T
L
S
C
F
G
----
62
PsiBlast_CBE
88.23
41%
-73
- C9 -
1HQH
3
ARGI1_RAT
B:
[6-305]
----
K
P
I
E
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
K
G
P
A
A
L
R
K
A
G
L
V
E
K
L
K
E
T
E
Y
N
V
R
D
H
G
D
L
A
F
V
D
V
P
N
D
S
P
F
Q
I
-----
V
K
N
P
R
S
V
G
K
A
N
E
Q
L
A
A
V
V
A
E
T
Q
K
N
G
T
I
S
V
V
L
G
G
D
H
S
M
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
C
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
S
S
G
N
L
H
G
Q
P
VAFL
L
K
E
L
K
G
K
F
P
D
V
P
G
F
S
W
--
V
-----
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
I
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
K
L
G
I
G
K
V
M
E
E
T
F
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
V
F
T
P
A
T
G
T
P
V
V
G
G
L
S
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
T
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
L
T
L
S
C
F
G
----
61
PsiBlast_CBE
88.20
41%
-73
- C9 -
1HQH
3
ARGI1_RAT
C:
[6-305]
----
K
P
I
E
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
K
G
P
A
A
L
R
K
A
G
L
V
E
K
L
K
E
T
E
Y
N
V
R
D
H
G
D
L
A
F
V
D
V
P
N
D
S
P
F
Q
I
-----
V
K
N
P
R
S
V
G
K
A
N
E
Q
L
A
A
V
V
A
E
T
Q
K
N
G
T
I
S
V
V
L
G
G
D
H
S
M
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
C
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
S
S
G
N
L
H
G
Q
P
VAFL
L
K
E
L
K
G
K
F
P
D
V
P
G
F
S
W
--
V
-----
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
I
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
K
L
G
I
G
K
V
M
E
E
T
F
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
V
F
T
P
A
T
G
T
P
V
V
G
G
L
S
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
T
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
L
T
L
S
C
F
G
----
64
PsiBlast_CBE
88.19
41%
-72
- C9 -
1HQF
3
ARGI1_RAT
B:
[6-305]
----
K
P
I
E
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
K
G
P
A
A
L
R
K
A
G
L
V
E
K
L
K
E
T
E
Y
N
V
R
D
H
G
D
L
A
F
V
D
V
P
N
D
S
P
F
Q
I
-----
V
K
N
P
R
S
V
G
K
A
N
E
Q
L
A
A
V
V
A
E
T
Q
K
N
G
T
I
S
V
V
L
G
G
D
H
S
M
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
C
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
S
S
G
N
L
H
G
Q
P
VAFL
L
K
E
L
K
G
K
F
P
D
V
P
G
F
S
W
--
V
-----
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
I
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
K
L
G
I
G
K
V
M
E
E
T
F
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
V
F
T
P
A
T
G
T
P
V
V
G
G
L
S
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
T
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
L
T
L
S
C
F
G
----
15
PsiBlast_PDB
88.13
41%
-73
- C9 -
1HQH
3
ARGI1_RAT
A:
[6-305]
----
K
P
I
E
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
K
G
P
A
A
L
R
K
A
G
L
V
E
K
L
K
E
T
E
Y
N
V
R
D
H
G
D
L
A
F
V
D
V
P
N
D
S
P
F
Q
I
-----
V
K
N
P
R
S
V
G
K
A
N
E
Q
L
A
A
V
V
A
E
T
Q
K
N
G
T
I
S
V
V
L
G
G
D
H
S
M
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
C
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
S
S
G
N
L
H
G
Q
P
V
A
F
L
L
K
E
L
K
G
K
F
P
D
V
P
G
F
S
W
--
V
-----
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
I
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
K
L
G
I
G
K
V
M
E
E
T
F
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
V
F
T
P
A
T
G
T
P
V
V
G
G
L
S
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
T
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
L
T
L
S
C
F
G
----
14
PsiBlast_PDB
87.75
41%
-72
- C9 -
1HQF
3
ARGI1_RAT
A:
[6-305]
----
K
P
I
E
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
K
G
P
A
A
L
R
K
A
G
L
V
E
K
L
K
E
T
E
Y
N
V
R
D
H
G
D
L
A
F
V
D
V
P
N
D
S
P
F
Q
I
-----
V
K
N
P
R
S
V
G
K
A
N
E
Q
L
A
A
V
V
A
E
T
Q
K
N
G
T
I
S
V
V
L
G
G
D
H
S
M
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
C
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
S
S
G
N
L
H
G
Q
P
V
A
F
L
L
K
E
L
K
G
K
F
P
D
V
P
G
F
S
W
--
V
-----
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
I
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
K
L
G
I
G
K
V
M
E
E
T
F
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
V
F
T
P
A
T
G
T
P
V
V
G
G
L
S
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
T
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
L
T
L
S
C
F
G
----
63
PsiBlast_CBE
87.67
41%
-72
- C9 -
1HQF
3
ARGI1_RAT
C:
[6-305]
----
K
P
I
E
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
K
G
P
A
A
L
R
K
A
G
L
V
E
K
L
K
E
T
E
Y
N
V
R
D
H
G
D
L
A
F
V
D
V
P
N
D
S
P
F
Q
I
-----
V
K
N
P
R
S
V
G
K
A
N
E
Q
L
A
A
V
V
A
E
T
Q
K
N
G
T
I
S
V
V
L
G
G
D
H
S
M
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
C
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
S
S
G
N
L
H
G
Q
P
VAFL
L
K
E
L
K
G
K
F
P
D
V
P
G
F
S
W
--
V
-----
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
I
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
K
L
G
I
G
K
V
M
E
E
T
F
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
V
F
T
P
A
T
G
T
P
V
V
G
G
L
S
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
T
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
L
T
L
S
C
F
G
----
98
PsiBlast_CBE
87.49
40%
-75
- C9 -
3MFW
4
ARGI1_HUMAN
A:
[5-305]
---
S
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
18
PsiBlast_PDB
87.13
40%
-72
- C9 -
1WVA
3
ARGI1_HUMAN
A:
[5-305]
---
S
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
79
PsiBlast_CBE
86.93
40%
-75
- C9 -
4FCK
3
ARGI1_HUMAN
B:
[6-305]
----
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
92
PsiBlast_CBE
86.89
40%
-75
- C9 -
3SKK
3
ARGI1_HUMAN
A:
[6-305]
----
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
100
PsiBlast_CBE
86.86
40%
-74
- C9 -
3MFV
3
ARGI1_HUMAN
A:
[6-305]
----
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
93
PsiBlast_CBE
86.68
40%
-73
- C9 -
3SJT
3
ARGI1_HUMAN
B:
[6-305]
----
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
83
PsiBlast_CBE
86.65
40%
-73
- C9 -
3THJ
3
ARGI1_HUMAN
B:
[6-305]
----
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
20
PsiBlast_PDB
86.55
40%
-71
- C9 -
2PHO
3
ARGI1_HUMAN
A:
[6-305]
----
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
82
PsiBlast_CBE
86.54
40%
-72
- C9 -
4FCI
3
ARGI1_HUMAN
A:
[5-305]
---
S
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
70
PsiBlast_CBE
86.54
40%
-72
- C9 -
4GWD
4
ARGI1_HUMAN
A:
[5-305]
---
S
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
97
PsiBlast_CBE
86.49
40%
-74
- C9 -
3MFW
4
ARGI1_HUMAN
B:
[5-305]
---
S
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
88
PsiBlast_CBE
86.48
40%
-75
- C9 -
3THE
3
ARGI1_HUMAN
A:
[6-305]
----
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
75
PsiBlast_CBE
86.48
40%
-72
- C9 -
4GSV
3
ARGI1_HUMAN
B:
[6-305]
----
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
99
PsiBlast_CBE
86.41
40%
-72
- C9 -
3MFV
3
ARGI1_HUMAN
B:
[6-305]
----
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
76
PsiBlast_CBE
86.37
40%
-72
- C9 -
4GSV
3
ARGI1_HUMAN
A:
[6-305]
----
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
73
PsiBlast_CBE
86.36
40%
-72
- C9 -
4GSZ
5
ARGI1_HUMAN
B:
[5-305]
---
S
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
91
PsiBlast_CBE
86.35
40%
-72
- C9 -
3SKK
3
ARGI1_HUMAN
B:
[6-305]
----
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
84
PsiBlast_CBE
86.33
40%
-72
- C9 -
3THJ
4
ARGI1_HUMAN
A:
[6-305]
----
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
87
PsiBlast_CBE
86.30
40%
-74
- C9 -
3THE
3
ARGI1_HUMAN
B:
[6-305]
----
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
86
PsiBlast_CBE
86.30
40%
-72
- C9 -
3THH
3
ARGI1_HUMAN
A:
[6-305]
----
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
95
PsiBlast_CBE
86.25
40%
-73
- C9 -
3MJL
3
ARGI1_HUMAN
B:
[6-305]
----
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
69
PsiBlast_CBE
86.20
40%
-71
- C9 -
4GWD
4
ARGI1_HUMAN
B:
[5-305]
---
S
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
74
PsiBlast_CBE
86.13
40%
-74
- C9 -
4GSZ
5
ARGI1_HUMAN
A:
[5-305]
---
S
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
80
PsiBlast_CBE
86.04
40%
-71
- C9 -
4FCK
3
ARGI1_HUMAN
A:
[6-305]
----
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
96
PsiBlast_CBE
85.67
40%
-73
- C9 -
3MJL
3
ARGI1_HUMAN
A:
[6-305]
----
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
94
PsiBlast_CBE
85.52
40%
-73
- C9 -
3SJT
3
ARGI1_HUMAN
A:
[6-305]
----
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
P
E
E
V
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
85
PsiBlast_CBE
85.40
40%
-72
- C9 -
3THH
3
ARGI1_HUMAN
B:
[6-305]
----
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
C
D
V
K
D
Y
G
D
L
---
P
F
A
D
I
P
N
-
D
S
P
-
F
Q
I
V
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
----
V
S
F
L
L
K
E
L
K
G
-
K
I
P
D
V
--
P
GFSWV
T
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
G
K
T
PEEV
T
R
---------------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----