@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1988: (2016-03-30 )
MKMIGFEKPFKLEEGNLFKVYEQRKPTPENDDILVKVNSISVNPVDTKQRQMKVTQAPRVLGFDAIGTVEAIGPDVTLFSPGDVVFYAGSPNRQGSNATYQLVSEAIVAKAPHNISANEAVSLPLTGITAYETFFDTFKISHNPSENVGKSVLIINGAGGVGSIATQIAKRYGLTVITTASRQETTEWCEKMGADIVLNHKEDLVRQFKEKEIPLVDYIFCTYNTDLYYNTMIELIKPLGHITTIVAFNEDQDLNALKLKSITFTHEFMFARPIHRTPDMIKQHEYLEDITKNIELGHYQPTTTQVFEGLSPENLYQAHQLLEKQSMIGKLVINI
Atome Classification :
(20 SA)
.........10.----------....-...-20........30........40........50..-------------.-------.----------..---.--.60........70......-..80.....-------------...90------------------------.-------------------------------------------------.-----------.......100...-.-...110.......120.....---....130.....--..-140.......150.......160.......170..-.-.-....180.......190.......200-.------------------......210-.......220....-.-..230.......-240...---....250---.---.------------.--..-...260.....-...270...-.-...280.......290.......300..--..--------..---...310.......320...-....330...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKMIGFEKPFKL----------EEG
N
-
L
F
K
-
V
Y
E
QRKPTPEND
D
I
L
V
K
V
N
S
I
SVNPVD
T
K
Q
R
Q
MK-------------V-------T----------QA---P--
R
V
LGFDAIGTVEAIGPD
V
T
-
L
FSPG
D
V
V
F
-------------YAGS-------------------------P-------------------------------------------------N-----------RQGS
N
A
T
Y
Q
L
V
S
E
-
A
-
I
V
AKAPHNISAN
E
A
--
V
SLPL---TG
I
T
A
Y
E
T
F
F
D
T
--FK-ISHNPSENVG
K
S
V
L
I
I
NGAGG
V
G
S
I
A
T
Q
I
A
K
-RYG-
L
-
T
-
V
I
T
TAS
R
Q
E
T
T
E
W
C
E
KMGA
D
I
V
LN
H
K
E
-
D
------------------
L
V
R
Q
F
K
EKE-I
P
L
V
D
Y
I
F
C
T
YNT
D
-
L
-
Y
Y
N
T
M
I
E
L
I
K
PL-G
H
I
T
T
I
---
V
A
FNED----Q---D------------L--
N
A
-
L
K
L
K
S
-
I
T
F
T
H
-
E
F
M
FARPIH-R-
T
P
D
M
I
K
Q
H
E
Y
L
E
D
I
T
KNIELGHYQ--P
T
--
T
T
--------
Q
V
---FEGL
S
P
E
N
L
Y
Q
A
H
Q
L
L
E
K
Q
-
S
M
I
G
K
L
V
INI
1
PsiBlast_PDB
95.23
69%
-96
- C1 -
3FBG
1
?
A:
[3-337]
L
K
A
I
G
F
E
Q
P
F
K
L
----------
S
D
G
N
-
L
F
K
-
T
F
N
L
D
I
P
E
P
K
V
H
E
I
L
V
K
I
Q
S
I
S
V
N
P
V
D
T
K
Q
R
L
M
D
-------------
V
-------
S
----------
K
A
---
P
--
R
V
L
G
F
D
A
I
G
V
V
E
S
V
G
N
E
V
T
-
M
F
N
Q
G
D
I
V
Y
-------------
Y
S
G
S
-------------------------
P
-------------------------------------------------
D
-----------
Q
N
G
S
N
A
E
Y
Q
L
I
N
E
-
R
-
L
V
A
K
A
P
K
N
I
S
A
E
Q
A
--
V
S
L
P
L
---
T
G
I
T
A
Y
E
T
L
F
D
V
--
F
G
-
I
S
R
N
R
N
E
N
E
G
K
T
L
L
I
I
N
G
A
G
G
V
G
S
I
A
T
Q
I
A
K
-
A
Y
G
-
L
-
R
-
V
I
T
T
A
S
R
N
E
T
I
E
W
T
K
K
M
G
A
D
I
V
L
N
H
K
E
-
S
------------------
L
L
N
Q
F
K
T
Q
G
-
I
E
L
V
D
Y
V
F
C
T
F
N
T
D
-
M
-
Y
Y
D
D
M
I
Q
L
V
K
P
R
-
G
H
I
A
T
I
---
V
A
F
E
N
D
----
Q
---
D
------------
L
--
N
A
-
L
K
P
K
S
-
L
S
F
S
H
-
E
F
M
F
A
R
P
L
N
-
Q
-
T
D
D
M
I
K
H
H
E
Y
L
E
D
I
T
N
K
V
E
Q
N
I
Y
Q
--
P
T
--
T
T
--------
K
V
---
I
E
G
L
T
T
E
N
I
Y
Q
A
H
Q
I
L
E
S
N
-
T
M
I
G
K
L
V
I
N
L
21
PsiBlast_CBE
95.11
69%
-98
- C1 -
3FBG
1
?
B:
[3-337]
L
K
A
I
G
F
E
Q
P
F
K
L
----------
S
D
G
N
-
L
F
K
-
T
F
N
L
D
I
P
E
P
K
V
H
E
I
L
V
K
I
Q
S
I
S
V
N
P
V
D
T
K
Q
R
L
M
D
-------------
V
-------
S
---------------
P
--
R
V
L
G
F
D
A
I
G
V
V
E
S
V
G
N
E
V
T
-
M
F
N
Q
G
D
I
V
Y
-------------
Y
S
G
S
-------------------------
P
-------------------------------------------------
D
-----------
Q
N
G
S
N
A
E
Y
Q
L
I
N
E
-
R
-
L
V
A
K
A
P
K
N
I
S
A
E
Q
A
--
V
S
L
P
L
---
T
G
I
T
A
Y
E
T
L
F
D
V
--
F
G
-
I
S
R
N
R
N
E
N
E
G
K
T
L
L
I
I
N
G
A
G
G
V
G
S
I
A
T
Q
I
A
K
-
A
Y
G
-
L
-
R
-
V
I
T
T
A
S
R
N
E
T
I
E
W
T
K
K
M
G
A
D
I
V
L
N
H
K
E
-
S
------------------
L
L
N
Q
F
K
T
Q
G
-
I
E
L
V
D
Y
V
F
C
T
F
N
T
D
-
M
-
Y
Y
D
D
M
I
Q
L
V
K
P
R
-
G
H
I
A
T
I
---
V
A
F
E
N
D
----
Q
---
D
------------
L
--
N
A
-
L
K
P
K
S
-
L
S
F
S
H
-
E
F
M
F
A
R
P
L
N
-
Q
-
T
D
D
M
I
K
H
H
E
Y
L
E
D
I
T
N
K
V
E
Q
N
I
Y
Q
--
P
T
--
T
T
--------
K
V
---
I
E
G
L
T
T
E
N
I
Y
Q
A
H
Q
I
L
E
S
N
--
M
I
G
K
L
V
I
N
L
44
HHSearch
93.79
69%
-95
- C1 -
3FBG
1
?
A:
[3-337]
L
K
A
I
G
F
E
Q
P
F
K
L
----------
S
D
G
N
-
L
F
K
T
F
N
-
L
D
I
P
E
P
K
V
H
E
I
L
V
K
I
Q
S
I
S
V
N
P
V
D
T
K
Q
R
L
M
D
-------------
V
-------
S
----------
K
A
---
P
--
R
V
L
G
F
D
A
I
G
V
V
E
S
V
G
N
E
V
T
-
M
F
N
Q
G
D
I
V
Y
-------------
Y
S
G
S
-------------------------
P
-------------------------------------------------
D
-----------
Q
N
G
S
N
A
E
Y
Q
L
I
N
E
-
R
-
L
V
A
K
A
P
K
N
I
S
A
E
Q
A
--
V
S
L
P
L
---
T
G
I
T
A
Y
E
T
L
F
D
V
--
F
G
-
I
S
R
N
R
N
E
N
E
G
K
T
L
L
I
I
N
G
A
G
G
V
G
S
I
A
T
Q
I
A
K
-
A
Y
G
-
L
-
R
-
V
I
T
T
A
S
R
N
E
T
I
E
W
T
K
K
M
G
A
D
I
V
L
N
H
K
E
-
S
------------------
L
L
N
Q
F
K
T
Q
G
-
I
E
L
V
D
Y
V
F
C
T
-
F
N
T
-
D
M
Y
Y
D
D
M
I
Q
L
V
K
P
R
-
G
H
I
A
T
I
---
V
A
F
E
N
D
----
Q
---
D
------------
L
--
N
A
-
L
K
P
K
S
-
L
S
F
S
H
-
E
F
M
F
A
R
P
L
N
-
Q
-
T
D
D
M
I
K
H
H
E
Y
L
E
D
I
T
N
K
V
E
Q
N
I
Y
Q
--
P
T
--
T
T
--------
K
V
I
E
G
L
-
T
T
--
E
N
I
Y
Q
A
H
Q
I
L
E
S
N
-
T
M
I
G
K
L
V
I
N
L
2
PsiBlast_PDB
72.71
41%
-72
- C1 -
4DVJ
-
?
A:
[24-356]
-
K
A
V
G
Y
N
K
P
A
P
I
----------
T
D
D
A
-
S
L
L
-
D
I
E
L
P
K
P
A
P
A
G
H
D
I
L
V
E
V
K
A
V
S
V
N
P
V
D
Y
K
V
R
R
S
T
-------------
P
-------
P
---------------
T
D
W
K
V
I
G
Y
D
A
A
G
I
V
S
A
V
G
P
D
V
T
-
L
F
R
P
G
D
E
V
F
-------------
Y
A
G
S
-------------------------
I
-------------------------------------------------
I
-----------
R
P
G
T
N
A
E
F
H
L
V
D
E
-
R
-
I
V
G
R
K
P
K
T
L
D
W
A
E
A
--
A
A
L
P
L
---
T
S
I
T
A
W
E
A
F
F
D
R
--
L
D
-
V
-
N
K
P
V
P
G
A
A
P
A
I
L
I
V
G
G
A
G
G
V
G
S
I
A
V
Q
I
A
R
Q
R
T
D
-
L
-
T
-
V
I
A
T
A
S
R
P
E
T
Q
E
W
V
K
S
L
G
A
H
H
V
I
D
H
S
K
-
P
------------------
L
A
A
E
V
A
A
L
G
-
L
G
A
P
A
F
V
F
S
T
T
H
T
D
-
K
-
H
A
A
E
I
A
D
L
I
A
P
Q
-
G
R
F
C
L
I
DDP
S
A
F
-----------
D
------------
I
--
M
L
-
F
K
R
K
A
-
V
S
I
H
H
-
E
L
M
F
T
R
P
M
F
-
G
-
T
P
D
M
S
E
Q
G
R
L
L
N
D
V
S
R
L
V
D
E
G
R
L
R
--
T
T
--
L
T
--------
N
R
---
L
S
P
I
N
A
A
N
L
K
Q
A
H
A
L
V
E
S
G
-
T
A
R
G
K
V
V
I
--
46
HHSearch
63.70
27%
-83
* C1 *
2EIH
1
?
A:
[1-342]
M
R
A
V
V
M
R
A
R
G
G
-------------
P
E
-
V
L
E
V
A
D
-
L
P
V
P
E
P
G
P
K
E
V
R
V
R
L
K
A
A
A
L
N
H
L
D
V
W
V
R
K
G
V
-------------
A
-------
S
PKL-------
P
L
---
P
--
H
V
L
G
A
D
G
S
G
V
V
D
A
V
G
P
G
V
E
-
G
F
A
P
G
D
E
V
V
-------------
I
N
P
G
LSCGRC
E
R
C
L
A
GEDNLCPRYQILG-
E
-------------------------------------------------
H
-----------
R
H
G
T
Y
A
E
Y
V
V
L
P
E
-
A
-
N
L
A
P
K
P
K
N
L
S
F
E
E
A
--
A
A
I
P
L
---
T
F
L
T
A
W
Q
M
V
V
D
K
--
L
G
-
V
R
------
P
G
D
D
V
L
V
M
A
A
G
S
G
V
S
V
A
A
I
Q
I
A
K
-
L
F
G
-
A
-
R
-
V
I
A
T
A
G
S
E
D
K
L
R
R
A
K
A
L
G
A
D
E
T
V
N
Y
T
H
-
P
D-----------------
W
P
K
E
V
R
R
L
T
G
G
K
G
A
D
K
V
V
D
H
-
T
G
A
-
L
-
Y
F
E
G
V
I
K
A
T
A
N
G
-
G
R
I
A
I
A
---
G
A
S
S
G
Y
EGT-
L
---
P
------------
F
--
A
H
-
V
F
Y
R
Q
-
L
S
I
L
G
-
S
--------------
T
M
A
S
K
S
R
L
F
P
I
L
R
F
V
E
E
G
K
L
K
--
P
V
--
V
G
--------
Q
V
---
L
-
P
L
--
E
A
A
A
E
G
H
R
L
L
E
E
R
-
R
V
F
G
K
V
V
L
Q
V
54
HHSearch
62.59
25%
-81
- C1 -
1QOR
2
QOR1_ECOLI
A:
[2-327]
A
T
R
I
E
F
H
K
H
G
G
-------------
P
E
-
V
L
Q
A
V
E
-
F
T
P
A
D
P
A
E
N
E
I
Q
V
E
N
K
A
I
G
I
N
F
I
D
T
Y
I
R
S
G
L
-------------
Y
-------
P
PP--------
S
L
---
P
--
S
G
L
G
T
E
A
A
G
I
V
S
K
V
G
S
G
V
K
-
H
I
K
A
G
D
R
V
V
-------------
Y
A
Q
S
---------------------------------------------------------------------------------------
A
L
G
A
Y
S
S
V
H
N
I
I
A
-
D
-
K
A
A
I
L
P
A
A
I
S
F
E
Q
A
--
A
A
S
F
L
---
K
G
L
T
V
Y
Y
L
L
R
K
T
--
Y
E
-
I
K
------
P
D
E
Q
F
L
F
H
A
A
A
G
G
V
G
L
I
A
C
Q
W
A
K
-
A
L
G
-
A
-
K
-
L
I
G
T
V
G
T
A
Q
K
A
Q
S
A
L
K
A
G
A
W
Q
V
I
N
Y
R
E
-
E
D-----------------
L
V
E
R
L
K
E
I
T
G
G
K
K
V
R
V
V
Y
D
S
-
V
G
R
-
D
-
T
W
E
R
S
L
D
C
L
Q
R
R
-
G
L
M
V
S
F
---
G
N
S
S
G
A
VTG-
V
---
N
------------
L
--
G
I
-
L
N
Q
K
G
-
S
L
Y
V
T
R
P
S
L
Q
G
Y
-
I
-----
T
T
R
E
E
L
T
E
A
S
N
E
L
F
S
L
I
A
S
G
V
I
K
--
V
D
V
A
E
Q
--------
Q
K
---
Y
-
P
L
--
K
D
A
Q
R
A
H
E
I
L
E
S
R
-
A
T
Q
G
S
S
L
L
I
P
40
HHSearch
62.13
22%
-81
- C1 -
3JYN
1
?
A:
[2-325]
A
K
R
I
Q
F
S
T
V
G
G
-------------
P
E
-
V
L
E
Y
V
D
-
F
E
P
E
A
P
G
P
Q
A
V
V
V
R
N
K
A
I
G
L
N
F
I
D
T
Y
Y
R
S
G
L
-------------
Y
-------
P
AP--------
F
L
---
P
--
S
G
L
G
A
E
G
A
G
V
V
E
A
V
G
D
E
V
T
-
R
F
K
V
G
D
R
V
A
-------------
Y
G
T
G
---------------------------------------------------------------------------------------
P
L
G
A
Y
S
E
V
H
V
L
P
E
-
A
-
N
L
V
K
L
A
D
S
V
S
F
E
Q
A
--
A
A
L
M
L
---
K
G
L
T
V
Q
Y
L
L
R
Q
T
--
Y
Q
-
V
K
------
P
G
E
I
I
L
F
H
A
A
A
G
G
V
G
S
L
A
C
Q
W
A
K
-
A
L
G
-
A
-
K
-
L
I
G
T
V
S
S
P
E
K
A
A
H
A
K
A
L
G
A
W
E
T
I
D
Y
S
H
-
E
D-----------------
V
A
K
R
V
L
E
L
T
D
G
K
K
C
P
V
V
Y
D
G
-
V
G
Q
-
D
-
T
W
L
T
S
L
D
S
V
A
P
R
-
G
L
V
V
S
F
---
G
N
A
S
G
P
----
V
S
GV
N
------------
L
--
G
I
-
L
A
Q
K
D
S
V
Y
V
T
R
-
P
T
L
G
-
S
Y
A
-----
N
N
A
Q
N
L
Q
T
M
A
D
E
L
F
D
M
L
A
S
G
K
L
K
--
V
D
--
G
I
--------
E
Q
---
Y
-
A
L
--
K
D
A
A
K
A
Q
I
E
L
S
A
R
-
R
T
T
G
S
T
I
L
I
P
49
HHSearch
62.00
25%
-81
- C1 -
3QWB
3
QOR_YEAST
A:
[9-332]
Q
K
V
I
L
I
D
E
I
G
G
-------------
Y
D
-
V
I
K
Y
E
D
-
Y
P
V
P
S
I
S
E
E
E
L
L
I
K
N
K
Y
T
G
V
N
Y
I
E
S
Y
F
R
K
G
I
-------------
Y
-------
P
C
---------
E
K
---
P
--
Y
V
L
G
R
E
A
S
G
T
V
V
A
K
G
K
G
V
T
-
N
F
E
V
G
D
Q
V
A
-------------
Y
I
S
-----------------------------------------------------------------------------------------
N
S
T
F
A
Q
Y
S
K
I
S
S
Q
G
-
P
V
M
K
L
P
K
G
T
S
D
E
E
L
--
K
L
Y
A
A
G
L
L
Q
V
L
T
A
L
S
F
T
N
E
A
--
Y
H
-
V
K
------
K
G
D
Y
V
L
L
F
A
A
A
G
G
V
G
L
I
L
N
Q
L
L
K
-
M
K
G
-
A
-
H
-
T
I
A
V
A
S
T
D
E
K
L
K
I
A
K
E
Y
G
A
E
Y
L
I
N
A
S
K
-
E
D-----------------
I
L
R
Q
V
L
K
F
T
N
G
K
G
V
D
A
S
F
D
S
-
V
G
K
-
D
-
T
F
E
I
S
L
A
A
L
K
R
K
-
G
V
F
V
S
F
---
G
N
A
S
G
L
IPP-
F
---
S
------------
I
--
T
R
-
L
S
P
K
N
-
I
T
L
V
R
-
P
Q
L
Y
G
Y
-
I
-----
A
D
P
E
E
W
K
Y
Y
S
D
E
F
F
G
L
V
N
S
K
K
L
N
--
I
K
--
I
Y
--------
K
T
---
Y
-
P
L
--
R
D
Y
R
T
A
A
A
D
I
E
S
R
-
K
T
V
G
K
L
V
L
E
I
55
HHSearch
61.91
26%
-82
- C1 -
3UOG
2
?
A:
[28-363]
M
Q
E
W
S
T
E
T
V
A
--------------
P
H
-
D
L
K
L
A
E
-
R
P
V
P
E
A
G
E
H
D
I
I
V
R
T
L
A
V
S
L
N
Y
R
D
K
L
V
L
E
T
G
-------------
M
-------
G
LDL-------
A
F
---
P
--
F
V
P
A
S
D
M
S
G
V
V
E
A
V
G
K
S
V
T
-
R
F
R
P
G
D
R
V
I
-------------
S
T
F
A
-------------------------
P
GWLD
G
L
R
P
G
T
GRTPAYETLGG----------------------------
A
-----------
H
P
G
V
L
S
E
Y
V
V
L
P
E
-
G
-
W
F
V
A
A
P
K
S
L
D
A
A
E
A
--
S
T
L
P
C
---
A
G
L
T
A
W
F
A
L
V
E
K
--
G
H
-
L
R
------
A
G
D
R
V
V
V
Q
G
T
-
G
G
V
A
L
F
G
L
Q
I
A
K
-
A
T
G
-
A
-
E
-
V
I
V
T
S
S
S
R
E
K
L
D
R
A
F
A
L
G
A
D
H
G
I
N
R
L
E
-
E
D-----------------
W
V
E
R
V
Y
A
L
T
G
D
R
G
A
D
H
I
L
E
I
-
A
G
G
-
A
-
G
L
G
Q
S
L
K
A
V
A
P
D
-
G
R
I
S
V
I
---
G
V
L
E
G
F
E
V
S
-
G
---
P
------------
V
--
G
P
-
L
L
L
K
S
-
P
V
V
Q
G
---------------
I
S
V
G
H
R
R
A
L
E
D
L
V
G
A
V
D
R
L
G
L
K
--
P
V
--
I
D
--------
M
R
---
Y
-
K
F
--
T
E
V
P
E
A
L
A
H
L
D
R
G
--
P
F
G
K
V
V
I
E
F
56
HHSearch
61.28
23%
-85
- C1 -
1WLY
-
CAA43_BURSP
A:
[2-331]
V
M
A
A
V
I
H
K
K
G
G
-------------
P
D
-
N
F
V
W
E
E
-
V
K
V
G
S
P
G
P
G
Q
V
R
L
R
N
T
A
I
G
V
N
F
L
D
T
Y
H
R
A
-----------------------------------
P
---
P
--
I
V
V
G
F
E
A
A
A
V
V
E
E
V
G
P
G
V
T
-
D
F
T
V
G
E
R
V
C
-------------
T
C
L
P
---------------------------------------------------------------------------------------
P
L
G
A
Y
S
Q
E
R
L
Y
P
A
-
E
-
K
L
I
K
V
P
K
D
L
D
L
D
D
V
H
L
A
G
L
M
L
---
K
G
M
T
A
Q
Y
L
L
H
Q
T
--
H
K
-
V
K
------
P
G
D
Y
V
L
I
H
A
A
A
G
G
M
G
H
I
M
V
P
W
A
R
-
H
L
G
-
A
-
T
-
V
I
G
T
V
S
T
E
E
K
A
E
T
A
R
K
L
G
C
H
H
T
I
N
Y
S
T
-
Q
D-----------------
F
A
E
V
V
R
E
I
T
G
G
K
G
V
D
V
V
Y
D
S
-
I
G
K
-
D
-
T
L
Q
K
S
L
D
C
L
R
P
R
-
G
M
C
A
A
Y
---
G
H
A
S
G
V
----
A
---
D
---------------
P
I
-
R
V
V
E
D
-
L
G
V
R
G
-
S
L
F
I
T
R
P
A
L
W
H
Y
M
S
N
R
S
E
I
D
E
G
S
K
C
L
F
D
A
V
K
A
G
V
L
H
--
S
S
--
V
A
--------
K
T
---
F
-
P
L
--
R
E
A
A
A
A
H
K
Y
M
G
G
R
-
Q
T
I
G
S
I
V
L
L
P
47
HHSearch
61.22
18%
-93
- C1 -
3S2E
7
?
A:
[3-338]
M
K
A
A
V
V
R
A
F
G
A
----------------
P
L
T
I
D
E
-
V
P
V
P
Q
P
G
P
G
Q
V
Q
V
K
I
E
A
S
G
V
C
H
T
D
L
H
A
A
D
G
D
-------------
W
-------
P
VKP-------
T
L
---
P
--
F
I
P
G
H
E
G
V
G
Y
V
S
A
V
G
S
G
V
S
-
R
V
K
E
G
D
R
V
G
-------------
V
P
W
L
YSACGYC
E
H
C
L
Q
GWETLCEK
Q
Q
N
T
G
Y
-------------------------------------------------
S
-----------
V
N
G
G
Y
G
E
Y
V
V
A
D
P
-
N
-
Y
V
G
L
L
P
D
K
V
G
F
V
E
I
--
A
P
I
L
C
---
A
G
V
T
V
Y
K
G
L
K
-
V
--
T
D
-
T
R
------
P
G
Q
W
V
V
I
S
G
I
-
G
G
L
G
H
V
A
V
Q
Y
A
R
-
A
M
G
-
L
-
R
-
V
A
A
V
D
I
D
D
A
K
L
N
L
A
R
R
L
G
A
E
V
A
V
N
A
R
D
-
T
D-----------------
P
A
A
W
L
Q
K
E
I
-
G
G
A
H
G
V
L
V
T
A
-
V
S
P
-
K
-
A
F
S
Q
A
I
G
M
V
R
R
G
-
G
T
I
A
L
N
---
G
L
P
P
G
D
----
F
---
G
------------
T
P
I
F
D
-
V
V
L
K
G
-
I
T
I
R
G
---------------
S
I
V
G
T
R
S
D
L
Q
E
S
L
D
F
A
A
H
G
D
V
K
--
A
T
--
V
---------
S
T
---
A
-
K
L
--
D
D
V
N
D
V
F
G
R
L
R
E
G
-
K
V
E
G
R
V
V
L
D
F
59
HHSearch
60.37
21%
-85
- C1 -
1E3I
4
ADH4_MOUSE
A:
[9-374]
C
K
A
A
I
A
W
K
T
G
S
----------------
P
L
C
I
E
E
-
I
E
V
S
P
P
K
A
C
E
V
R
I
Q
V
I
A
T
C
V
C
P
T
D
I
N
A
T
D
P
K
-------------
K
-------
K
A
---------
L
F
---
P
--
V
V
L
G
H
E
C
A
G
I
V
E
S
V
G
P
G
V
T
-
N
F
K
P
G
D
K
V
I
-------------
P
F
F
A
-------------------------
P
QCKRCKLCLSPLTNLCGKLRNFKYPTIDQELMEDRTSRFTCKG
R
S
I
Y
H
F
M
-----------
G
V
S
S
F
S
Q
Y
T
V
V
S
E
-
A
-
N
L
A
R
V
D
D
E
A
N
L
E
R
V
--
C
L
I
G
C
---
G
F
S
S
G
Y
G
A
A
I
N
T
--
A
K
-
V
T
------
P
G
S
T
C
A
V
F
G
L
-
G
C
V
G
L
S
A
I
I
G
C
K
-
I
A
G
-
A
S
R
-
I
I
A
I
D
I
N
G
E
K
F
P
K
A
K
A
L
G
A
T
D
C
L
N
P
R
E
-
L
DKP---------------
V
Q
D
V
I
T
E
L
T
-
A
G
G
V
D
Y
S
L
D
C
-
A
G
T
A
Q
-
T
L
K
A
A
V
D
C
T
V
L
G
W
G
S
C
T
V
V
---
G
A
K
V
D
E
----
M
---
T
------------
I
--
P
T
V
D
V
I
L
G
-
R
S
I
N
G
-
T
F
F
-----------
G
G
W
K
S
V
D
S
V
P
N
L
V
S
D
Y
K
N
K
K
F
D
LD
L
L
--
V
T
--------
H
A
---
L
-
P
F
--
E
S
I
N
D
A
I
D
L
M
K
E
G
-
K
S
I
R
T
I
L
---
5
PsiBlast_PDB
60.31
26%
-77
- C1 -
2EIH
1
?
A:
[23-342]
-------------------------------------
P
E
P
G
P
K
E
V
R
V
R
L
K
A
A
A
L
N
H
L
D
V
W
V
R
K
G
V
-------------
A
-------
S
----------
P
K
LPL
P
--
H
V
L
G
A
D
G
S
G
V
V
D
A
V
G
P
G
V
E
-
G
F
A
P
G
D
E
V
V
I
NPGLSCGRC
E
R
C
L
A
G
E
-------------------------
D
-------------------------------------------------
N
LCPRYQILGEH
R
H
G
T
Y
A
E
Y
V
V
L
P
E
-
A
-
N
L
A
P
K
P
K
N
L
S
F
E
E
A
--
A
A
I
P
L
---
T
F
L
T
A
W
Q
M
V
V
D
----
K
-
L
G
V
R
P
----
G
D
D
V
L
V
M
A
A
G
S
G
V
S
V
A
A
I
Q
I
A
K
-
L
F
G
-
A
-
R
-
V
I
A
T
A
G
S
E
D
K
L
R
R
A
K
A
L
G
A
D
E
T
V
N
Y
T
H
P
D
------------------
W
P
K
E
V
R
R
L
T
-
G
G
K
G
A
D
K
V
V
D
H
T
G
A
-
L
-
Y
F
E
G
V
I
K
A
T
A
N
G
-
G
R
I
A
I
A
---
G
A
S
S
G
Y
----
E
---
G
----------------------
T
-
L
P
F
A
H
---
V
F
Y
R
Q
L
S
-
I
-
L
G
S
T
M
A
S
K
S
R
L
F
P
I
L
R
F
V
E
E
G
K
L
K
--
P
V
--
V
G
--------
Q
V
------
L
P
L
E
A
A
A
E
G
H
R
L
L
E
E
R
-
R
V
F
G
K
V
V
L
Q
V
53
HHSearch
60.20
23%
-85
- C1 -
1F8F
6
?
A:
[7-370]
I
I
A
A
V
T
P
C
K
G
A
----------------
D
F
E
L
Q
A
-
L
K
I
R
Q
P
Q
G
D
E
V
L
V
K
V
V
A
T
G
M
C
H
T
D
L
I
V
R
D
Q
K
-------------
Y
-------
P
V---------
P
L
---
P
--
A
V
L
G
H
E
G
S
G
I
I
E
A
I
G
P
N
V
T
-
E
L
Q
V
G
D
H
V
V
-------------
L
S
Y
G
-------------------------
Y
CGKC
T
Q
C
N
T
GNPAYCSEFFGRNFSGADSEGNHALCVNDHF---------
F
-----------
A
Q
S
S
F
A
T
Y
A
L
S
R
E
-
N
-
N
T
V
K
V
T
K
D
V
P
I
E
L
L
--
G
P
L
G
C
---
G
I
Q
T
G
A
G
A
C
I
N
A
--
L
K
-
V
T
------
P
A
S
S
F
V
T
W
G
A
-
G
A
V
G
L
S
A
L
L
A
A
K
-
V
C
G
-
A
-
S
I
I
I
A
V
D
I
V
E
S
R
L
E
L
A
K
Q
L
G
A
T
H
V
I
N
S
K
T
-
Q
D-----------------
P
V
A
A
I
K
E
I
T
-
D
G
G
V
N
F
A
L
E
S
-
T
G
S
P
E
-
I
L
K
Q
G
V
D
A
L
G
I
L
-
G
K
I
A
V
V
---
G
A
P
Q
L
G
T
T
A
Q
F
---
D
------------
V
--
N
D
-
L
L
L
G
G
-
K
T
I
L
G
-
V
V
E
G
-----------
S
G
S
P
K
K
F
I
P
E
L
V
R
L
Y
Q
Q
G
K
F
P
--
F
D
Q-
L
V
--------
K
F
---
Y
-
A
F
--
D
E
I
N
Q
A
A
I
D
S
R
K
G
-
I
-
T
L
K
P
I
I
K
I
41
HHSearch
58.48
25%
-77
- C1 -
1JVB
2
ADH_SULSO
A:
[1-347]
M
R
A
V
R
L
V
E
I
G
K
----------------
P
L
S
L
Q
E
-
I
G
V
P
K
P
K
G
P
Q
V
L
I
K
V
E
A
A
G
V
C
H
S
D
V
H
M
R
Q
G
R
-------------
F
-------
G
NLRIVEDLGV
K
L
---
P
--
V
T
L
G
H
E
I
A
G
K
I
E
E
V
G
D
E
V
V
-
G
Y
S
K
G
D
L
V
A
-------------
V
N
P
W
-------------------------
Q
GEGNC
Y
Y
C
R
I
GEEHLCDSPRWLGI-------------------------
N
-----------
F
D
G
A
Y
A
E
Y
V
I
V
P
H
-
Y
-
K
Y
M
Y
K
L
R
R
L
N
A
V
E
A
--
A
P
L
T
C
---
S
G
I
T
T
Y
R
A
V
R
-
K
--
A
S
-
L
D
------
P
T
K
T
L
L
V
V
G
A
G
G
G
L
G
T
M
A
V
Q
I
A
K
-
A
V
S
G
A
-
T
-
I
I
G
V
D
V
R
E
E
A
V
E
A
A
K
R
A
G
A
D
Y
V
I
N
A
S
M
-
Q
D-----------------
P
L
A
E
I
R
R
I
T
E
S
K
G
V
D
A
V
I
D
L
-
N
N
S
E
K
-
T
L
S
V
Y
P
K
A
L
A
K
Q
-
G
K
Y
V
M
V
---
G
L
F
G
A
D
----
L
---
H
------------
Y
H
A
P
L
-
I
T
L
S
E
-
I
Q
F
V
---------------
G
S
L
V
G
N
Q
S
D
F
L
G
I
M
R
L
A
E
A
G
K
V
K
--
P
M
--
I
T
--------
K
T
---
M
-
K
L
--
E
E
A
N
E
A
I
D
N
L
E
N
F
-
K
A
I
G
R
Q
V
L
I
P
51
HHSearch
57.37
23%
-79
- C1 -
2C0C
1
ZADH2_HUMAN
A:
[24-360]
M
Q
K
L
V
V
T
R
L
S
P
N
-----------
F
R
E
-
A
V
T
L
S
R
D
C
P
V
P
L
P
G
D
G
D
L
L
V
R
N
R
F
V
G
V
N
A
S
D
I
N
Y
S
A
G
R
-------------
Y
-------
D
PSV-------
K
P
---
P
--
F
D
I
G
F
E
G
I
G
E
V
V
A
L
G
L
S
A
S
A
R
Y
T
V
G
Q
A
V
A
-------------
Y
M
A
-----------------------------------------------------------------------------------------
P
G
S
F
A
E
Y
T
V
V
P
A
-
S
-
I
A
T
P
V
P
S
V
K
--
P
E
Y
--
L
T
L
L
V
---
S
G
T
T
A
Y
I
S
L
K
E
L
--
G
G
-
L
S
------
E
G
K
K
V
L
V
T
A
A
A
G
G
T
G
Q
F
A
M
Q
L
S
K
-
K
A
K
-
C
-
H
-
V
I
G
T
C
S
S
D
E
K
S
A
F
L
K
S
L
G
C
D
R
P
I
N
Y
K
T
-
E
P-----------------
V
G
T
V
L
K
Q
E
Y
-
P
E
G
V
D
V
V
Y
E
S
-
V
G
G
-
A
-
M
F
D
L
A
V
D
A
L
A
T
K
-
G
R
L
I
V
I
---
G
F
I
S
G
Y
----
Q
---
T
PTG
L
S
P
V
KAGT
L
P
--
A
K
-
L
L
K
K
S
-
A
S
V
Q
G
-
F
F
L
N
H
Y
---------
L
S
K
Y
Q
A
A
M
S
H
L
L
E
M
C
V
S
G
D
L
V
--
C
E
--
V
D
LGDLSPEG
R
F
---
T
-
G
L
--
E
S
I
F
R
A
V
N
Y
M
Y
M
G
-
K
N
T
G
K
I
V
V
E
L
57
HHSearch
57.22
28%
-81
- C1 -
3TQH
3
?
A:
[7-320]
M
K
A
I
Q
F
D
Q
F
G
P
-------------
P
K
-
V
L
K
L
V
D
-
T
P
T
P
E
Y
R
K
N
Q
M
L
I
K
V
H
A
A
S
L
N
P
I
D
Y
K
T
R
N
G
S
-------------
G
-------
F
V
A
K
K
L
K
N---
N
L
---
P
--
S
G
L
G
Y
D
F
S
G
E
V
I
E
L
G
S
D
V
N
-
N
V
N
I
G
D
K
V
M
-------------
G
I
A
G
-------------------------
F
P------------------------------------------------
D
-----------
H
P
C
C
Y
A
E
Y
V
C
A
S
P
-
D
-
T
I
I
Q
K
L
E
K
L
S
F
L
Q
A
--
A
S
L
P
T
---
A
G
L
T
A
L
Q
A
L
N
Q
---
A
E
-
V
K
------
Q
G
D
V
V
L
I
H
A
G
A
G
G
V
G
H
L
A
I
Q
L
A
K
-
Q
K
G
-
T
-
T
-
V
I
T
T
A
-
S
K
R
N
H
A
F
L
K
A
L
G
A
E
Q
C
I
N
Y
H
E
-
E
D-----------------
F
L
L
----
A
I
-
S
T
P
V
D
A
V
I
D
L
-
V
G
G
-
D
-
V
G
I
Q
S
I
D
C
L
K
E
T
-
G
C
I
V
S
V
---
P
T
I
T
A
G
----
R
---
V
------------
I
--
E
V
-
A
K
Q
K
H
-
R
R
A
F
---
G
L
L
---------
K
--
Q
F
N
I
E
E
L
H
Y
L
G
K
L
V
S
E
D
K
L
R
--
I
E
--
I
S
--------
R
I
---
F
-
Q
L
--
S
E
A
V
T
A
H
E
L
L
E
T
G
-
H
V
R
G
K
L
V
F
K
V
42
HHSearch
56.61
23%
-70
- C1 -
3KRT
1
?
A:
[31-420]
Y
R
A
I
T
V
H
K
D
E
T
E
MFAGLETRDK
D
P
R
K
-
S
I
H
L
D
D
-
V
P
V
P
E
L
G
P
G
E
A
L
V
A
V
M
A
S
S
V
N
Y
N
S
V
H
T
S
I
F
E
PLST
F
G
F
L
E
R
Y
G
R
V
SDLAKRH
D
----------
L
P
---
Y
--
H
V
I
G
S
D
L
A
G
V
V
L
R
T
G
P
G
V
N
-
A
W
Q
A
G
D
E
V
V
-------------
A
H
C
L
-------------------------
S
VELESSDGHNDTMLDPEQRIWGFE-------------------------
T
-----------
N
F
G
G
L
A
E
I
A
L
V
K
S
-
N
-
Q
L
M
P
K
P
D
H
L
S
W
E
E
A
--
A
A
P
G
L
---
V
N
S
T
A
Y
R
Q
L
V
S
R
NG
A
G
-
M
K
------
Q
G
D
N
V
L
I
W
G
A
S
G
G
L
G
S
Y
A
T
Q
F
A
L
-
A
G
G
-
A
-
N
-
P
I
C
V
V
S
S
P
Q
K
A
E
I
C
R
A
M
G
A
E
A
I
I
D
R
N
A
-
E
GYRFWKDENTQD
P
K
E
W
K
R
F
G
K
R
I
R
E
L
T
G
G
E
D
I
D
I
V
F
E
H
-
P
G
R
-
E
-
T
F
G
A
S
V
F
V
T
R
K
G
-
G
T
I
T
T
C
---
A
S
T
S
G
Y
M
H
E
-
Y
---
D
------------
N
--
R
Y
-
L
W
M
S
L
-
K
R
I
I
---------------
G
S
H
F
A
N
Y
R
E
A
W
E
A
N
R
L
I
A
K
G
R
I
H
--
P
T
--
L
S
--------
K
V
---
Y
-
S
L
--
E
D
T
G
Q
A
A
Y
D
V
H
R
N
-
L
H
Q
G
K
V
G
V
L
-
60
HHSearch
55.15
22%
-76
- C1 -
3JV7
7
?
A:
[1-345]
M
K
A
V
Q
Y
T
E
I
G
S
----------------
E
P
V
V
V
D
-
I
P
T
P
T
P
G
P
G
E
I
L
L
K
V
T
A
A
G
L
C
H
S
D
I
F
V
M
D
M
P
-------------
A
AQY----
A
Y---------
G
L
---
P
--
L
T
L
G
H
E
G
V
G
T
V
A
E
L
G
E
G
V
T
-
G
F
G
V
G
D
A
V
A
-------------
V
Y
G
P
-------------------------
W
GCGAC
H
A
C
A
R
GRENYCTRAADLGITPPGL--------------------
G
-----------
S
P
G
S
M
A
E
Y
M
I
V
D
S
-
A
R
H
L
V
P
I
G
-
D
L
D
P
V
A
A
--
A
P
L
T
D
---
A
G
L
T
P
Y
H
A
I
S
R
V
--
L
P
L
L
G
------
P
G
S
T
A
V
V
I
G
V
-
G
G
L
G
H
V
G
I
Q
I
L
R
-
A
V
S
-
A
A
R
-
V
I
A
V
D
L
D
D
D
R
L
A
L
A
R
E
V
G
A
D
A
A
V
K
S
G
A
-
G
------------------
A
A
D
A
I
R
E
L
T
G
G
Q
G
A
T
A
V
F
D
F
-
V
G
A
Q
S
-
T
I
D
T
A
Q
Q
V
V
A
V
D
-
G
H
I
S
V
V
---
G
I
H
A
G
A
----
H
---
A
----------------------
K
-
V
G
F
F
M
-
I
P
F
G
A
S
V
V
-----
T
P
Y
W
G
T
R
S
E
L
M
E
V
V
A
L
A
R
A
G
R
L
D
--
I
---
H
T
--------
E
T
---
F
-
T
L
--
D
E
G
P
A
A
Y
R
R
L
R
E
G
-
S
I
R
G
R
G
V
V
V
P
45
HHSearch
54.99
18%
-83
- C1 -
3GMS
-
?
A:
[3-329]
G
K
L
I
Q
F
H
K
F
G
N
-------------
P
K
D
V
L
Q
V
E
Y
-
K
N
I
E
P
L
K
D
N
E
V
F
V
R
M
L
V
R
P
I
N
P
S
D
L
I
P
I
T
G
A
-------------
Y
-------
A
HRI-------
P
L
---
P
--
N
I
P
G
Y
E
G
V
G
I
V
E
N
V
G
A
F
V
S
-
R
E
L
I
G
K
R
V
L
-------------
P
L
R
----------------------------------------------------------------------------------------
G
E
G
T
W
Q
E
Y
V
K
T
S
A
-
D
-
F
V
V
P
I
P
D
S
I
D
D
F
T
A
--
A
Q
M
Y
I
---
N
P
L
T
A
W
V
T
C
T
E
T
--
L
N
-
L
Q
------
R
N
D
V
L
L
V
N
A
C
G
S
A
I
G
H
L
F
A
Q
L
S
Q
-
I
L
N
-
F
-
R
-
L
I
A
V
T
R
N
N
K
H
T
E
E
L
L
R
L
G
A
A
Y
V
I
D
T
S
T
-
A
P-----------------
L
Y
E
T
V
M
E
L
T
N
G
I
G
A
D
A
A
I
D
S
-
I
G
G
-
P
-
D
G
N
E
L
A
F
S
L
R
P
N
-
G
H
F
L
T
I
---
G
L
L
S
G
I
Q---
V
---
N
------------
W
--
A
E
-
I
V
T
K
A
-
K
V
H
A
N
-
I
F
H
L
R
H
W
N
D
-
E
--
V
S
P
Y
K
W
Q
E
T
F
R
H
L
I
R
L
V
E
N
E
Q
L
R
--
F
M
K-
V
H
--------
S
T
---
Y
-
E
L
--
A
D
V
K
A
A
V
D
V
V
Q
S
A
E
K
T
K
G
K
V
F
L
T
S