@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1995: (2016-03-30 )
MILTLTLNPSVDISYPLTALKLDDVNRVQEVSKTAGGKGLNVTRVLAQVGEPVLASGFIGGELGQFIAKKLDHADIKHAFYNIKGETRNCIAILHEGQQTEILEQGPEIDNQEAAGFIKHFEQLLEKVEAVAISGSLPKGLNQDYYAQIIERCQNKGVPVILDCSGATLQTVLENPYKPTVIKPNISELYQLLNQPLDESLESLKQAVSQPLFEGIEWIIVSLGAQGAFAKHNHTFYRVNIPTINVLNPVGSGDSTVAGITSAILNHENDHDLLKKANTLGMLNAQEAQTGYVNLNNYDELFNQIEVLEV
Atome Classification :
(20 SA)
.........10.-......-.20........30........40........50........60.-.......70........80..-..-....90......--.--.100.......110.......120.......130.......140.......150.......160......---.170.-......180.......190.......200-........210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
L
T
L
TLNPS
V
D
-
I
SYP
L
T
-
A
L
K
LD
D
V
N
R
V
Q
E
V
S
K
TAGGKG
L
N
V
T
R
V
L
A
QVG
E
P
V
L
A
SGFI
G
G
E
-
L
G
Q
F
I
A
K
KL
D
H
A
D
I
K
H
A
F
Y
NI-KG-ETR
N
C
I
A
I
LHEG--Q--
Q
T
E
I
L
E
QGPEID
N
Q
E
A
A
G
F
I
K
H
F
E
Q
L
L
E
K
V
E
A
VAISGSLPKGL
N
Q
D
Y
Y
A
Q
I
I
E
R
C
QNKGV
P
V
I
L
DCSG
A
T
---
L
Q
T
V
L
-ENPYKPTVIKP
N
I
S
E
L
Y
Q
L
L
NQ
P
L
D
E
S
-
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
I
E
W
I
I
VSLGAQGAFAKHN
H
T
F
Y
R
V
NI
P
T
I
N
V
LNPVGSGD
S
T
V
A
G
I
T
S
A
I
LNHE
N
D
H
D
L
L
K
K
A
N
TLGMLN
A
Q
EAQT
G
Y
V
NLN
N
Y
D
E
L
F
N
Q
I
E
VLEV
1
PsiBlast_PDB
99.56
99%
-107
- C2 -
2JGV
-
LACC_STAA8
A:
[22-330]
-
I
L
T
L
T
L
N
P
S
V
D
-
I
S
Y
P
L
T
-
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
Y
N
I
-
K
G
-
E
T
R
N
C
I
A
I
L
H
E
G
--
Q
--
Q
T
E
I
L
E
Q
G
P
E
I
D
N
Q
E
A
A
G
F
I
K
H
F
E
Q
L
L
E
K
V
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
-
E
N
P
Y
K
P
T
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
E
S
-
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
G
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
3
PsiBlast_PDB
98.70
98%
-104
- C2 -
2JG1
2
LACC_STAA8
A:
[22-330]
-
I
L
T
L
T
L
N
P
S
V
D
-
I
S
Y
P
L
T
-
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
Y
N
I
-
K
G
-
E
T
R
N
C
I
A
I
L
H
E
G
--
Q
--
Q
T
E
I
L
E
Q
G
P
E
I
D
N
Q
E
A
A
G
F
I
K
H
F
E
Q
M
M
E
K
V
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
-
E
N
P
Y
K
P
T
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
E
S
-
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
G
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
22
PsiBlast_CBE
98.25
99%
-101
- C2 -
2JGV
1
LACC_STAA8
B:
[22-330]
-
I
L
T
L
T
L
N
P
S
V
D
-
I
S
Y
P
L
T
-
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
Y
N
I
-
K
G
-
E
T
R
N
C
I
A
I
L
H
E
G
--
Q
--
Q
T
E
I
L
E
Q
G
P
E
I
D
N
Q
E
A
A
G
F
I
K
H
F
E
Q
L
L
E
K
V
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
-
E
N
P
Y
K
P
T
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
E
S
-
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
G
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
21
PsiBlast_CBE
97.94
99%
-99
- C2 -
2JGV
1
LACC_STAA8
D:
[22-330]
-
I
L
T
L
T
L
N
P
S
V
D
-
I
S
Y
P
L
T
-
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
Y
N
I
-
K
G
-
E
T
R
N
C
I
A
I
L
H
E
G
--
Q
--
Q
T
E
I
L
E
Q
G
P
E
I
D
N
Q
E
A
A
G
F
I
K
H
F
E
Q
L
L
E
K
V
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
-
E
N
P
Y
K
P
T
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
E
S
-
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
G
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
23
PsiBlast_CBE
97.15
98%
-100
- C2 -
2JG1
2
LACC_STAA8
D:
[22-330]
-
I
L
T
L
T
L
N
P
S
V
D
-
I
S
Y
P
L
T
-
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
Y
N
I
-
K
G
-
E
T
R
N
C
I
A
I
L
H
E
G
--
Q
--
Q
T
E
I
L
E
Q
G
P
E
I
D
N
Q
E
A
A
G
F
I
K
H
F
E
Q
M
M
E
K
V
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
-
E
N
P
Y
K
P
T
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
E
S
-
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
G
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
32
HHSearch
96.92
97%
-100
- C2 -
2JG1
2
LACC_STAA8
A:
[21-330]
M
I
L
T
L
T
L
N
P
S
V
D
-
I
S
Y
P
L
T
-
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
Y
N
I
-
K
G
-
E
T
R
N
C
I
A
I
L
H
E
G
--
Q
--
Q
T
E
I
L
E
Q
G
P
E
I
D
N
Q
E
A
A
G
F
I
K
H
F
E
Q
M
M
E
K
V
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
L
Q
T
V
L
E
N
P
-
Y
---
K
P
T
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
E
S
-
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
G
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
24
PsiBlast_CBE
96.87
98%
-99
- C2 -
2JG1
3
LACC_STAA8
C:
[22-330]
-
I
L
T
L
T
L
N
P
S
V
D
-
I
S
Y
P
L
T
-
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
Y
N
I
-
K
G
-
E
T
R
N
C
I
A
I
L
H
E
G
--
Q
--
Q
T
E
I
L
E
Q
G
P
E
I
D
N
Q
E
A
A
G
F
I
K
H
F
E
Q
M
M
E
K
V
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
-
E
N
P
Y
K
P
T
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
E
S
-
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
G
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
25
PsiBlast_CBE
96.62
98%
-97
- C2 -
2JG1
3
LACC_STAA8
B:
[22-330]
-
I
L
T
L
T
L
N
P
S
V
D
-
I
S
Y
P
L
T
-
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
Y
N
I
-
K
G
-
E
T
R
N
C
I
A
I
L
H
E
G
--
Q
--
Q
T
E
I
L
E
Q
G
P
E
I
D
N
Q
E
A
A
G
F
I
K
H
F
E
Q
M
M
E
K
V
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
-
E
N
P
Y
K
P
T
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
E
S
-
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
G
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
2
PsiBlast_PDB
94.33
99%
-91
- C2 -
2Q5R
-
LACC_STAAC
A:
[2-310]
-
I
L
T
L
T
L
N
P
S
V
D
-
I
S
Y
P
L
T
-
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
Y
N
I
-
K
G
-
E
T
R
N
C
I
A
I
L
H
E
G
--
Q
--
Q
T
E
I
L
E
Q
G
P
E
I
D
N
Q
E
A
A
G
F
I
K
H
F
E
Q
L
L
E
K
V
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
-
E
N
P
Y
K
P
T
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
E
S
-
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
G
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
4
PsiBlast_PDB
83.35
49%
-95
- C2 -
2AWD
6
LACC_ENTFA
A:
[3-313]
L
I
V
T
V
T
M
N
P
S
I
D
-
I
S
Y
L
L
D
-
H
L
K
L
D
T
V
N
R
T
S
Q
V
T
K
T
P
G
G
K
G
L
N
V
T
R
V
I
H
D
L
G
G
D
V
I
A
T
G
V
L
G
G
F
-
H
G
A
F
I
A
N
E
L
K
K
A
N
I
P
Q
A
F
T
S
I
-
K
E
-
E
T
R
D
S
I
A
I
L
H
E
G
--
N
--
Q
T
E
I
L
E
A
G
P
T
V
S
P
E
E
I
S
N
F
L
E
N
F
D
Q
L
I
K
Q
A
E
I
V
T
I
S
G
S
L
A
K
G
L
P
S
D
F
Y
Q
E
L
V
Q
K
A
H
A
Q
E
V
K
V
L
L
D
T
S
G
D
S
---
L
R
Q
V
L
-
Q
G
P
W
K
P
Y
L
I
K
P
N
L
E
E
L
E
G
L
L
G
Q
D
F
S
E
N
P
L
-
A
A
V
Q
T
A
L
T
K
P
M
F
A
G
I
E
W
I
V
I
S
L
G
K
D
G
A
I
A
K
H
H
D
Q
F
Y
R
V
K
I
P
T
I
Q
A
K
N
P
V
G
S
G
D
A
T
I
A
G
L
A
Y
G
L
A
K
D
A
P
A
A
E
L
L
K
W
G
M
A
A
G
M
A
N
A
Q
E
R
M
T
G
H
V
D
V
E
N
V
K
K
H
L
M
N
I
Q
V
V
E
I
35
HHSearch
82.93
50%
-98
- C2 -
2F02
1
LACC_ENTFA
A:
[3-313]
L
I
V
T
V
T
M
N
P
S
I
D
-
I
S
Y
L
L
D
-
H
L
K
L
D
T
V
N
R
T
S
Q
V
T
K
T
P
G
G
K
G
L
N
V
T
R
V
I
H
D
L
G
G
D
V
I
A
T
G
V
L
G
G
F
-
H
G
A
F
I
A
N
E
L
K
K
A
N
I
P
Q
A
F
T
S
I
-
K
E
-
E
T
R
D
S
I
A
I
L
H
E
G
--
N
--
Q
T
E
I
L
E
A
G
P
T
V
S
P
E
E
I
S
N
F
L
E
N
F
D
Q
L
I
K
Q
A
E
I
V
T
I
S
G
S
L
A
K
G
L
P
S
D
F
Y
Q
E
L
V
Q
K
A
H
A
Q
E
V
K
V
L
L
D
T
S
G
D
S
---
L
R
Q
V
L
-
Q
G
P
W
K
P
Y
L
I
K
P
N
L
E
E
L
E
G
L
L
G
Q
D
F
S
E
N
-
P
L
A
A
V
Q
T
A
L
T
K
P
M
F
A
G
I
E
W
I
V
I
S
L
G
K
D
G
A
I
A
K
H
H
D
Q
F
Y
R
V
K
I
P
T
I
Q
A
K
N
P
V
G
S
G
D
A
T
I
A
G
L
A
Y
G
L
A
K
D
A
P
A
A
E
L
L
K
W
G
M
A
A
G
M
A
N
A
Q
E
R
M
T
G
H
V
D
V
E
N
V
K
K
H
L
M
N
I
Q
V
V
E
I
5
PsiBlast_PDB
82.42
49%
-98
- C2 -
2F02
1
LACC_ENTFA
A:
[3-313]
L
I
V
T
V
T
M
N
P
S
I
D
-
I
S
Y
L
L
D
-
H
L
K
L
D
T
V
N
R
T
S
Q
V
T
K
T
P
G
G
K
G
L
N
V
T
R
V
I
H
D
L
G
G
D
V
I
A
T
G
V
L
G
G
F
-
H
G
A
F
I
A
N
E
L
K
K
A
N
I
P
Q
A
F
T
S
I
-
K
E
-
E
T
R
D
S
I
A
I
L
H
E
G
--
N
--
Q
T
E
I
L
E
A
G
P
T
V
S
P
E
E
I
S
N
F
L
E
N
F
D
Q
L
I
K
Q
A
E
I
V
T
I
S
G
S
L
A
K
G
L
P
S
D
F
Y
Q
E
L
V
Q
K
A
H
A
Q
E
V
K
V
L
L
D
T
S
G
D
S
---
L
R
Q
V
L
-
Q
G
P
W
K
P
Y
L
I
K
P
N
L
E
E
L
E
G
L
L
G
Q
D
F
S
E
N
P
L
-
A
A
V
Q
T
A
L
T
K
P
M
F
A
G
I
E
W
I
V
I
S
L
G
K
D
G
A
I
A
K
H
H
D
Q
F
Y
R
V
K
I
P
T
I
Q
A
K
N
P
V
G
S
G
D
A
T
I
A
G
L
A
Y
G
L
A
K
D
A
P
A
A
E
L
L
K
W
G
M
A
A
G
M
A
N
A
Q
E
R
M
T
G
H
V
D
V
E
N
V
K
K
H
L
M
N
I
Q
V
V
E
I
6
PsiBlast_PDB
69.88
32%
-75
- C2 -
2ABQ
3
?
A:
[2-299]
-
I
Y
T
V
T
L
N
P
S
I
D
-
Y
I
V
Q
V
E
-
N
F
Q
Q
G
V
V
N
R
S
E
R
D
R
K
Q
P
G
G
K
G
I
N
V
S
R
V
L
K
R
L
G
H
E
T
K
A
L
G
F
L
G
G
F
-
T
G
A
Y
V
R
N
A
L
E
K
E
E
I
G
L
S
F
I
E
V
-
E
G
-
D
T
R
I
N
V
K
I
K
G
K
---
Q
--
E
T
E
L
N
G
T
A
P
L
I
K
K
E
H
V
Q
A
L
L
E
Q
L
T
E
-
L
E
K
G
D
V
L
V
L
A
G
S
V
P
Q
A
M
P
Q
T
I
Y
R
S
M
T
Q
I
A
K
E
R
G
A
F
V
A
V
D
T
S
G
E
A
---
L
H
E
V
L
---
A
A
K
P
S
F
I
K
P
N
H
H
E
L
S
E
L
V
S
K
P
I
-
A
S
-
I
-
E
D
A
I
P
H
V
Q
R
L
I
G
E
G
I
E
S
I
L
V
S
F
A
G
D
G
A
L
F
A
S
A
E
G
M
F
H
V
N
V
P
S
G
E
V
R
N
S
V
G
A
G
D
S
V
V
A
G
F
L
A
A
L
Q
E
G
K
S
L
E
D
A
V
P
F
A
V
A
A
G
--
S
A
T
A
F
S
D
G
F
C
T
R
E
E
V
E
R
L
Q
Q
Q
L
Q
----
10
PsiBlast_PDB
69.48
27%
-82
- C2 -
3HIC
1
?
A:
[3-309]
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
L
F
I
R
G
-
E
L
E
K
R
K
T
N
R
V
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
-
N
L
D
K
L
Y
A
I
L
K
E
K
H
I
N
H
D
F
L
V
E
-
A
G
T
S
T
R
E
C
F
V
V
L
S
D
D
--
T
N
G
S
T
M
I
P
E
A
G
F
T
V
S
Q
T
N
K
D
N
L
L
K
Q
I
A
K
K
V
K
K
E
D
M
V
V
I
A
G
S
P
P
P
H
Y
T
L
S
D
F
K
E
L
L
R
T
V
K
A
T
G
A
F
L
G
C
D
N
S
G
E
Y
---
L
N
L
A
V
-
E
M
G
V
D
--
F
I
K
P
N
E
D
E
V
I
A
I
L
----
D
E
K
-
T
-
N
S
L
E
E
N
I
-
R
T
L
A
E
K
I
P
Y
L
V
V
S
L
G
A
K
G
S
I
C
A
H
N
G
K
L
Y
Q
V
I
P
P
K
V
Q
E
R
N
D
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
M
N
M
P
I
T
E
T
L
K
V
A
T
G
C
S
A
S
K
V
M
Q
Q
----
F
D
L
E
A
A
G
K
L
K
N
Q
V
S
I
I
Q
L
9
PsiBlast_PDB
69.40
27%
-80
- C2 -
3Q1Y
2
?
A:
[3-309]
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
L
F
I
R
G
-
E
L
E
K
R
K
T
N
R
V
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
-
N
L
D
K
L
Y
A
I
L
K
E
K
H
I
N
H
D
F
L
V
E
-
A
G
T
S
T
R
E
C
F
V
V
L
S
D
D
--
T
N
G
S
T
M
I
P
E
A
G
F
T
V
S
Q
T
N
K
D
N
L
L
K
Q
I
A
K
K
V
K
K
E
D
M
V
V
I
A
G
S
P
P
P
H
Y
T
L
S
D
F
K
E
L
L
R
T
V
K
A
T
G
A
F
L
G
C
D
N
S
G
E
Y
---
L
N
L
A
V
-
E
--
M
G
V
D
F
I
K
P
N
E
D
E
V
I
A
I
L
----
D
E
K
-
T
-
N
S
L
E
E
N
I
-
R
T
L
A
E
K
I
P
Y
L
V
V
S
L
G
A
K
G
S
I
C
A
H
N
G
K
L
Y
Q
V
I
P
P
K
V
Q
E
R
N
D
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
M
N
M
P
I
T
E
T
L
K
V
A
T
G
C
S
A
S
A
V
M
Q
Q
D
S
S
S
F
D
L
E
A
A
G
K
L
K
N
Q
V
S
I
I
Q
L
38
HHSearch
69.10
33%
-80
- C2 -
2ABQ
3
?
A:
[1-299]
M
I
Y
T
V
T
L
N
P
S
I
D
-
Y
I
V
Q
V
E
-
N
F
Q
Q
G
V
V
N
R
S
E
R
D
R
K
Q
P
G
G
K
G
I
N
V
S
R
V
L
K
R
L
G
H
E
T
K
A
L
G
F
L
G
G
F
-
T
G
A
Y
V
R
N
A
L
E
K
E
E
I
G
L
S
F
I
E
V
-
E
G
-
D
T
R
I
N
V
K
I
K
G
-
K
--
Q
--
E
T
E
L
N
G
T
A
P
L
I
K
K
E
H
V
Q
A
L
L
E
Q
L
T
-
E
L
E
K
G
D
V
L
V
L
A
G
S
V
P
Q
A
M
P
Q
T
I
Y
R
S
M
T
Q
I
A
K
E
R
G
A
F
V
A
V
D
T
S
G
E
A
---
L
H
E
V
L
A
A
---
K
P
S
F
I
K
P
N
H
H
E
L
S
E
L
V
S
K
P
I
A
S
--
I
-
E
D
A
I
P
H
V
Q
R
L
I
G
E
G
I
E
S
I
L
V
S
F
A
G
D
G
A
L
F
A
S
A
E
G
M
F
H
V
N
V
P
S
G
E
V
R
N
S
V
G
A
G
D
S
V
V
A
G
F
L
A
A
L
Q
E
G
K
S
L
E
D
A
V
P
F
A
V
A
A
G
S
A
T
A
F
S
D
G
--
F
C
T
R
E
E
V
E
R
L
Q
Q
Q
L
Q
----
34
HHSearch
68.31
30%
-82
- C2 -
2JG5
-
?
A:
[1-303]
M
I
Y
T
V
T
F
N
P
S
I
D
-
Y
V
I
F
T
N
-
D
F
K
I
D
G
L
N
R
A
T
A
T
Y
K
F
A
G
G
K
G
I
N
V
S
R
V
L
K
T
L
D
V
E
S
T
A
L
G
F
A
G
G
F
-
P
G
K
F
I
I
D
T
L
N
N
S
A
I
Q
S
N
F
I
E
V
-
D
E
-
D
T
R
I
N
V
K
L
-
K
T
G
--
Q
--
E
T
E
I
N
A
P
G
P
H
I
T
S
T
Q
F
E
Q
L
L
Q
Q
I
K
N
-
T
T
S
E
D
I
V
I
V
A
G
S
V
P
S
S
I
P
S
D
A
Y
A
Q
I
A
Q
I
T
A
Q
T
G
A
K
L
V
V
D
A
E
K
E
L
---
A
E
S
V
L
-
P
--
Y
H
P
L
F
I
K
P
N
K
D
E
L
E
V
M
F
N
T
T
V
N
S
--
D
-
A
D
V
I
K
Y
G
R
L
L
V
D
K
G
A
Q
S
V
I
V
S
L
G
G
D
G
A
I
Y
I
D
K
E
I
S
I
K
A
V
N
P
Q
G
K
V
V
N
T
V
G
S
G
D
S
T
V
A
G
M
V
A
G
I
A
S
G
L
S
I
E
K
A
F
Q
Q
A
V
A
C
G
T
A
T
A
F
D
E
D
--
L
A
T
R
D
A
I
E
K
I
K
S
Q
V
T
I
S
V
L
12
PsiBlast_PDB
67.68
27%
-80
- C2 -
3JUL
2
?
A:
[3-309]
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
L
F
I
R
G
-
E
L
E
K
R
K
T
N
R
V
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
-
N
L
D
K
L
Y
A
I
L
K
E
K
H
I
N
H
D
F
L
V
E
-
A
G
T
S
T
R
E
C
F
V
V
L
S
D
D
--
T
N
G
S
T
M
I
P
E
A
G
F
T
V
S
Q
T
N
K
D
N
L
L
K
Q
I
A
K
K
V
K
K
E
D
M
V
V
I
A
G
S
P
P
P
H
Y
T
L
S
D
F
K
E
L
L
R
T
V
K
A
T
G
A
F
L
G
C
D
N
S
G
E
Y
---
L
N
L
A
V
-
E
M
G
V
D
--
F
I
K
P
N
E
D
E
V
I
A
I
L
----
D
E
K
-
T
-
N
S
L
E
E
N
I
-
R
T
L
A
E
K
I
P
Y
L
V
V
S
L
G
A
K
G
S
I
C
A
H
N
G
K
L
Y
Q
V
I
P
P
-------
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
M
N
M
P
I
T
E
T
L
K
V
A
T
G
C
S
A
S
K
V
M
Q
Q
----
F
D
L
E
A
A
G
K
L
K
N
Q
V
S
I
I
Q
L
11
PsiBlast_PDB
67.36
27%
-75
- C2 -
3IE7
3
?
A:
[3-309]
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
L
F
I
R
G
-
E
L
E
K
R
K
T
N
R
V
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
-
N
L
D
K
L
Y
A
I
L
K
E
K
H
I
N
H
D
F
L
V
E
-
A
G
T
S
T
R
E
C
F
V
V
L
S
D
D
--
T
N
G
S
T
M
I
P
E
A
G
F
T
V
S
Q
T
N
K
D
N
L
L
K
Q
I
A
K
K
V
K
K
E
D
M
V
V
I
A
G
S
P
P
P
H
Y
T
L
S
D
F
K
E
L
L
R
T
V
K
A
T
G
A
F
L
G
C
D
N
S
G
E
Y
---
L
N
L
A
V
-
E
M
G
V
D
--
F
I
K
P
N
E
D
E
V
I
A
I
L
----
D
E
K
-
T
-
N
S
L
E
E
N
I
-
R
T
L
A
E
K
I
P
Y
L
V
V
S
L
G
A
K
G
S
I
C
A
H
N
G
K
L
Y
Q
V
I
P
P
K
V
Q
E
R
N
D
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
M
N
M
P
I
T
E
T
L
K
V
A
T
G
C
S
A
S
K
V
M
Q
Q
D
S
S
S
F
D
L
E
A
A
G
K
L
K
N
Q
V
S
I
I
Q
L
33
HHSearch
66.32
27%
-75
- C2 -
3IE7
3
?
A:
[3-309]
L
I
Y
T
I
T
L
N
P
A
I
D
-
R
L
L
F
I
R
G
E
L
E
K
R
K
T
N
R
V
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
N
L
-
D
K
L
Y
A
I
L
K
E
K
H
I
N
H
D
F
L
V
E
A
G
T
-
S
T
R
E
C
F
V
V
L
S
D
D
TN
G
--
S
T
M
I
P
E
A
G
F
T
V
S
Q
T
N
K
D
N
L
L
K
Q
I
A
K
K
V
K
K
E
D
M
V
V
I
A
G
S
P
P
P
H
Y
T
L
S
D
F
K
E
L
L
R
T
V
K
A
T
G
A
F
L
G
C
D
N
S
G
E
Y
---
L
N
L
A
V
E
M
---
G
V
D
F
I
K
P
N
E
D
E
V
I
A
I
L
D
E
K
T
N
------
S
L
E
E
N
I
R
T
L
A
E
-
K
I
P
Y
L
V
V
S
L
G
A
K
G
S
I
C
A
H
N
G
K
L
Y
Q
V
I
P
P
K
V
Q
E
R
N
D
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
M
N
M
P
I
T
E
T
L
K
V
A
T
G
C
S
A
S
K
V
M
Q
Q
D
S
S
S
F
D
L
E
A
A
G
K
L
K
N
Q
V
S
I
I
Q
L