@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2078: (2016-04-01 )
MTKKVYFNHDGGVDDLVSLFLLLQMENVQLIGVSTIGADCYLEPSLSASVKIINRFSNEDIQVAPSYERGKNPFPKEWRMHAFFMDALPILNEPVKHVASNVSDKEAFEDIIQTLKRQSEKVTLLFTGPLTDLAKALQKDSSIVQYIEKLVWMGGTFLPKGNVEEPEHDGSAEWNAYWDPEAVKIVFDSDIEIDMVALESTNQVPLTLDVRQRWANERQYTGIDFLGVSYAAVPPLTHFITNSTYFLWDVLTTAYIGNKDLVHSIEKKVDVISYGPSQGKTFECKDGRKINVINHVDNNAFFDYITALAKKVN
Atome Classification :
(25 SA)
.........10........20...-.-.-...30........40........50........-60---.---........70------........80........90.--------..--------....-----.100.......110.......120.......130.......-140-.......150.......160.......170.......180.......-190........200....-...210.......220....-...230.......240.......250.......260.......270.....-...280..--.....290.......300.......310.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
K
K
V
Y
FNHDG
G
V
D
D
L
V
S
L
F
L
L
L
Q-M-E-
N
V
Q
L
I
G
V
S
TIGA
D
C
Y
LEPSL
S
A
S
V
K
I
I
N
RFSNE-
D
----
I
---
Q
VAPSYERGK------NPF
P
K
E
W
R
M
H
A
F
F
M
D
A
L
P
I
L
N
--------
E
P
--------
V
K
H
V
-----
A
SNV
S
D
K
E
A
F
E
D
I
I
Q
T
L
K
RQS
E
K
V
T
L
L
F
TG
P
L
T
D
L
A
K
A
L
QK-
D
S
S
-
I
V
Q
Y
I
E
K
L
V
WMGGTFLPKGNVEEPEHDGSAEWN
A
Y
WDP
E
A
V
K
I
V
FDS-D-I
E
I
D
M
V
A
LESTNQV
P
L
-
T
L
D
V
R
Q
RWANERQYTGI
D
F
L-GVSYAAVP
P
L
T
H
F
ITNS
T
Y
F
L
W
D
V
L
T
T
AYIG
N
K
D
L
V
H
S
I
E
KKV
D
V
-
I
SYGP-SQG
K
T
F
EC--KDG
R
K
I
N
V
I
N
HVDN
N
A
F
F
D
Y
I
T
A
L
A
KKVN
21
PsiBlast_CBE
94.85
63%
-97
- C1 -
2C40
2
?
B:
[2-310]
--
K
K
V
Y
F
N
H
D
G
G
V
D
D
L
V
S
L
F
L
L
L
Q
-
M
-
D
-
N
V
E
L
T
G
V
S
V
I
P
A
D
C
Y
L
E
P
A
M
S
A
S
R
K
I
I
D
R
F
G
K
N
-
T
----
I
---
E
V
A
A
S
N
S
R
G
K
------
N
P
F
P
K
D
W
R
M
H
A
F
Y
V
D
A
L
P
I
L
N
--------
E
S
--------
G
K
-
V
-----
V
T
H
V
A
A
K
P
A
H
H
H
L
I
E
T
L
L
Q
T
E
E
K
T
T
L
L
F
T
G
P
L
T
D
L
A
R
A
L
Y
E
-
A
P
I
-
I
E
N
K
I
K
R
L
V
W
M
G
G
T
F
R
T
A
G
N
V
H
E
P
E
H
D
G
T
A
E
W
N
S
F
W
D
P
E
A
V
A
R
V
W
E
A
-
N
-
I
E
I
D
L
I
T
L
E
S
T
N
Q
V
P
L
-
T
I
D
I
R
E
Q
W
A
K
E
R
K
Y
I
G
I
D
F
L
-
G
Q
C
Y
A
I
V
P
P
----------
Y
L
W
D
V
L
T
A
A
F
V
G
K
A
D
L
A
K
V
Q
T
I
N
S
I
V
-
H
T
Y
G
P
-
S
Q
G
R
T
V
E
T
--
D
D
G
R
P
V
H
V
V
Y
D
V
N
H
D
R
F
F
D
Y
I
T
R
L
A
K
K
V
-
41
HHSearch
94.12
64%
-97
- C1 -
2C40
2
?
A:
[1-310]
-
M
K
K
V
Y
F
N
H
D
G
G
V
D
D
L
V
S
L
F
L
L
L
Q
-
M
-
D
-
N
V
E
L
T
G
V
S
V
I
P
A
D
C
Y
L
E
P
A
M
S
A
S
R
K
I
I
D
R
F
G
K
N
-
T
----
I
---
E
V
A
A
S
N
S
R
G
K
------
N
P
F
P
K
D
W
R
M
H
A
F
Y
V
D
A
L
P
I
L
N
--------
E
S
---------
G
K
V
-----
V
T
H
V
A
A
K
P
A
H
H
H
L
I
E
T
L
L
Q
T
E
E
K
T
T
L
L
F
T
G
P
L
T
D
L
A
R
A
L
Y
E
-
A
P
I
-
I
E
N
K
I
K
R
L
V
W
M
G
G
T
F
R
T
A
G
N
V
H
E
P
E
H
D
G
T
A
E
W
N
S
F
W
D
P
E
A
V
A
R
V
W
E
A
-
N
-
I
E
I
D
L
I
T
L
E
S
T
N
Q
V
P
L
-
T
I
D
I
R
E
Q
W
A
K
E
R
K
Y
I
G
I
D
F
L
-
G
Q
C
Y
A
I
V
P
P
L
--------
Y
Y
L
W
D
V
L
T
A
A
F
V
G
K
A
D
L
A
K
V
Q
T
I
N
S
I
V
-
H
T
Y
G
P
-
S
Q
G
R
T
V
E
T
--
D
D
G
R
P
V
H
V
V
Y
D
V
N
H
D
R
F
F
D
Y
I
T
R
L
A
K
K
V
-
1
PsiBlast_PDB
93.80
63%
-98
- C1 -
2C40
2
?
A:
[2-310]
--
K
K
V
Y
F
N
H
D
G
G
V
D
D
L
V
S
L
F
L
L
L
Q
-
M
-
D
-
N
V
E
L
T
G
V
S
V
I
P
A
D
C
Y
L
E
P
A
M
S
A
S
R
K
I
I
D
R
F
G
K
N
-
T
----
I
---
E
V
A
A
S
N
S
R
G
K
------
N
P
F
P
K
D
W
R
M
H
A
F
Y
V
D
A
L
P
I
L
N
--------
E
S
--------
G
K
-
V
-----
V
T
H
V
A
A
K
P
A
H
H
H
L
I
E
T
L
L
Q
T
E
E
K
T
T
L
L
F
T
G
P
L
T
D
L
A
R
A
L
Y
E
-
A
P
I
-
I
E
N
K
I
K
R
L
V
W
M
G
G
T
F
R
T
A
G
N
V
H
E
P
E
H
D
G
T
A
E
W
N
S
F
W
D
P
E
A
V
A
R
V
W
E
A
-
N
-
I
E
I
D
L
I
T
L
E
S
T
N
Q
V
P
L
-
T
I
D
I
R
E
Q
W
A
K
E
R
K
Y
I
G
I
D
F
L
-
G
Q
C
Y
A
I
V
P
P
L
--------
Y
Y
L
W
D
V
L
T
A
A
F
V
G
K
A
D
L
A
K
V
Q
T
I
N
S
I
V
-
H
T
Y
G
P
-
S
Q
G
R
T
V
E
T
--
D
D
G
R
P
V
H
V
V
Y
D
V
N
H
D
R
F
F
D
Y
I
T
R
L
A
K
K
V
-
44
HHSearch
71.20
32%
-82
* C1 *
3EPW
3
?
A:
[13-338]
-
A
K
N
V
V
L
D
H
D
G
N
L
D
D
F
V
A
M
V
L
L
A
S
-
N
-
T
E
K
V
R
L
I
G
A
L
C
T
D
A
D
C
F
V
E
N
G
F
N
V
T
G
K
I
M
C
L
M
H
N
N
M
N
----
L
P
L
F
P
I
G
K
S
A
A
T
A
V
------
N
P
F
P
K
E
W
R
C
L
A
K
N
M
D
D
M
P
I
L
N
--------
I
P
--------
E
N
V
E
L
W
D
K
I
K
A
E
N
E
K
Y
E
G
Q
Q
L
L
A
D
L
V
M
N
S
E
E
K
V
T
I
C
V
T
G
P
L
S
N
V
A
W
C
I
D
K
-
Y
G
E
K
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
R
G
N
V
F
L
P
S
T
D
G
T
A
E
W
N
I
Y
W
D
P
A
S
A
K
T
V
F
G
C
-
P
G
L
R
R
I
M
F
S
L
D
S
T
N
T
V
P
V
-
R
S
P
Y
V
Q
R
F
G
E
Q
-
T
N
F
L
L
S
I
L
V
G
T
M
W
A
M
C
T
H
C
E
L
L
R
D
G
D
G
Y
Y
A
W
D
A
L
T
A
A
Y
V
V
D
Q
K
V
A
N
V
D
P
V
P
I
D
V
-
V
V
D
K
Q
P
N
E
G
A
T
V
R
T
DA
E
N
Y
P
L
T
F
V
A
R
N
P
E
A
E
F
F
L
D
M
L
L
R
S
A
R
A
C
-
5
PsiBlast_PDB
71.16
33%
-85
- C1 -
2FF2
3
?
A:
[15-280]
--
K
N
V
V
L
D
H
D
G
N
L
D
D
F
V
A
M
V
L
L
A
S
N
T
-
E
-
K
V
R
L
I
G
A
L
C
T
D
A
D
C
F
V
E
N
G
F
N
V
T
G
K
I
M
C
L
M
H
N
N
-
M
NL
P
L
F
---
P
I
G
K
S
A
A
T
A
V
------
N
P
F
P
K
E
W
R
C
L
A
K
N
M
D
D
M
P
I
L
N
--------
I
P
E
N
V
E
L
W
D
K
I
K
A
E
-----
N
E
K
Y
E
G
Q
Q
L
L
A
D
L
V
M
N
---
S
E
E
K
V
T
I
C
V
T
G
P
L
S
N
V
A
W
C
I
D
K
Y
G
E
K
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
R
G
N
V
F
L
P
S
T
D
G
T
A
E
W
N
I
Y
W
D
P
A
S
A
K
T
V
F
G
C
P
G
-
L
R
R
I
M
F
S
L
D
S
T
N
T
V
P
V
-
R
S
P
Y
V
Q
R
F
G
E
Q
T
N
F
L
L
S
I
L
V
-
G
T
M
W
A
M
C
T
H
C
E
L
L
R
D
G
D
G
Y
Y
A
W
D
A
L
T
A
A
Y
V
-------------------------------------------------------------
22
PsiBlast_CBE
70.90
33%
-86
- C1 -
3EPX
2
?
B:
[14-279]
--
K
N
V
V
L
D
H
D
G
N
L
D
D
F
V
A
M
V
L
L
A
S
N
T
-
E
-
K
V
R
L
I
G
A
L
C
T
D
A
D
C
F
V
E
N
G
F
N
V
T
G
K
I
M
C
L
M
H
N
N
-
M
NL
P
L
F
---
P
I
G
K
S
A
A
T
A
V
------
N
P
F
P
K
E
W
R
C
L
A
K
N
M
D
D
M
P
I
L
N
--------
I
P
E
N
V
E
L
W
D
K
I
K
A
E
-----
N
E
K
Y
E
G
Q
Q
L
L
A
D
L
V
M
N
---
S
E
E
K
V
T
I
C
V
T
G
P
L
S
N
V
A
W
C
I
D
K
Y
G
E
K
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
R
G
N
V
F
L
P
S
T
D
G
T
A
E
W
N
I
Y
W
D
P
A
S
A
K
T
V
F
G
C
P
G
-
L
R
R
I
M
F
S
L
D
S
T
N
T
V
P
V
-
R
S
P
Y
V
Q
R
F
G
E
Q
T
N
F
L
L
S
I
L
V
-
G
T
M
W
A
M
C
T
H
C
E
L
L
R
D
G
--
Y
Y
A
W
D
A
L
T
A
A
Y
V
-------------------------------------------------------------
23
PsiBlast_CBE
70.84
33%
-87
- C1 -
3EPW
3
?
B:
[14-279]
--
K
N
V
V
L
D
H
D
G
N
L
D
D
F
V
A
M
V
L
L
A
S
N
T
-
E
-
K
V
R
L
I
G
A
L
C
T
D
A
D
C
F
V
E
N
G
F
N
V
T
G
K
I
M
C
L
M
H
N
N
-
M
NLPL
F
---
P
I
G
K
S
A
A
T
A
V
------
N
P
F
P
K
E
W
R
C
L
A
K
N
M
D
D
M
P
I
L
N
--------
I
P
ENVELWDK
I
K
A
E
-----
N
E
K
Y
E
G
Q
Q
L
L
A
D
L
V
M
N
---
S
E
E
K
V
T
I
C
V
T
G
P
L
S
N
V
A
W
C
I
D
K
Y
G
E
K
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
R
G
N
V
F
L
P
S
T
D
G
T
A
E
W
N
I
Y
W
D
P
A
S
A
K
T
V
F
G
C
P
G
-
L
R
R
I
M
F
S
L
D
S
T
N
T
V
P
V
-
R
S
P
Y
V
Q
R
F
G
E
Q
T
N
F
L
L
S
I
L
V
-
G
T
M
W
A
M
C
T
H
C
E
L
L
R
D
G
D
G
Y
Y
A
W
D
A
L
T
A
A
Y
V
-------------------------------------------------------------
3
PsiBlast_PDB
70.02
33%
-88
- C1 -
3EPX
2
?
A:
[14-279]
--
K
N
V
V
L
D
H
D
G
N
L
D
D
F
V
A
M
V
L
L
A
S
N
T
-
E
-
K
V
R
L
I
G
A
L
C
T
D
A
D
C
F
V
E
N
G
F
N
V
T
G
K
I
M
C
L
M
H
N
N
-
M
NL
P
L
F
---
P
I
G
K
S
A
A
T
A
V
------
N
P
F
P
K
E
W
R
C
L
A
K
N
M
D
D
M
P
I
L
N
--------
I
P
E
N
V
E
L
W
D
K
I
K
A
E
-----
N
E
K
Y
E
G
Q
Q
L
L
A
D
L
V
M
N
---
S
E
E
K
V
T
I
C
V
T
G
P
L
S
N
V
A
W
C
I
D
K
Y
G
E
K
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
R
G
N
V
F
L
P
S
T
D
G
T
A
E
W
N
I
Y
W
D
P
A
S
A
K
T
V
F
G
C
P
G
-
L
R
R
I
M
F
S
L
D
S
T
N
T
V
P
V
-
R
S
P
Y
V
Q
R
F
G
E
Q
T
N
F
L
L
S
I
L
V
-
G
T
M
W
A
M
C
T
H
C
E
----
G
D
G
Y
Y
A
W
D
A
L
T
A
A
Y
V
-------------------------------------------------------------
24
PsiBlast_CBE
69.12
33%
-87
- C1 -
2FF2
2
?
B:
[15-280]
--
K
N
V
V
L
D
H
D
G
N
L
D
D
F
V
A
M
V
L
L
A
S
N
T
-
E
-
K
V
R
L
I
G
A
L
C
T
D
A
D
C
F
V
E
N
G
F
N
V
T
G
K
I
M
C
L
M
H
N
N
-
M
NL
P
L
F
---
P
I
G
K
S
A
A
T
A
V
------
N
P
F
P
K
E
W
R
C
L
A
K
N
M
D
D
M
P
I
L
N
--------
I
P
E
N
V
E
L
W
D
K
I
K
A
E
-----
N
E
K
Y
E
G
Q
Q
L
L
A
D
L
V
M
N
---
S
E
E
K
V
T
I
C
V
T
G
P
L
S
N
V
A
W
C
I
D
K
Y
G
E
K
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
R
G
N
V
F
L
P
S
T
D
G
T
A
E
W
N
I
Y
W
D
P
A
S
A
K
T
V
F
G
C
P
G
-
L
R
R
I
M
F
S
L
D
S
T
N
T
V
P
V
-
R
S
P
Y
V
Q
R
F
G
E
Q
T
N
F
L
L
S
I
L
V
-
G
T
M
W
A
M
C
T
H
C
E
L
L
R
D
G
D
G
Y
Y
A
W
D
A
L
T
A
A
Y
V
-------------------------------------------------------------
4
PsiBlast_PDB
69.00
33%
-89
- C1 -
1HP0
2
?
A:
[15-280]
--
K
N
V
V
L
D
H
D
G
N
L
D
D
F
V
A
M
V
L
L
A
S
N
T
-
E
-
K
V
R
L
I
G
A
L
C
T
D
A
D
C
F
V
E
N
G
F
N
V
T
G
K
I
M
C
L
M
H
N
N
-
M
NL
P
L
F
---
P
I
G
K
S
A
A
T
A
V
------
N
P
F
P
K
E
W
R
C
L
A
K
N
M
D
D
M
P
I
L
N
--------
I
P
E
N
V
E
L
W
D
K
I
K
A
E
-----
N
E
K
Y
E
G
Q
Q
L
L
A
D
L
V
M
N
---
S
E
E
K
V
T
I
C
V
T
G
P
L
S
N
V
A
W
C
I
D
K
Y
G
E
K
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
R
G
N
V
F
L
P
S
T
D
G
T
A
E
W
N
I
Y
W
D
P
A
S
A
K
T
V
F
G
C
P
G
-
L
R
R
I
M
F
S
L
D
S
T
N
T
V
P
V
-
R
S
P
Y
V
Q
R
F
G
E
Q
T
N
F
L
L
S
I
L
V
-
G
T
M
W
A
M
C
T
H
--------
G
Y
Y
A
W
D
A
L
T
A
A
Y
V
-------------------------------------------------------------
2
PsiBlast_PDB
68.84
33%
-86
- C1 -
3EPW
3
?
A:
[14-279]
--
K
N
V
V
L
D
H
D
G
N
L
D
D
F
V
A
M
V
L
L
A
S
N
T
-
E
-
K
V
R
L
I
G
A
L
C
T
D
A
D
C
F
V
E
N
G
F
N
V
T
G
K
I
M
C
L
M
H
N
N
-
M
N
L
P
L
F
---
P
I
G
K
S
A
A
T
A
V
------
N
P
F
P
K
E
W
R
C
L
A
K
N
M
D
D
M
P
I
L
N
--------
I
P
E
N
V
E
L
W
D
K
I
K
A
E
-----
N
E
K
Y
E
G
Q
Q
L
L
A
D
L
V
M
N
---
S
E
E
K
V
T
I
C
V
T
G
P
L
S
N
V
A
W
C
I
D
K
Y
G
E
K
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
R
G
N
V
F
L
P
S
T
D
G
T
A
E
W
N
I
Y
W
D
P
A
S
A
K
T
V
F
G
C
P
G
-
L
R
R
I
M
F
S
L
D
S
T
N
T
V
P
V
-
R
S
P
Y
V
Q
R
F
G
E
Q
T
N
F
L
L
S
I
L
V
-
G
T
M
W
A
M
C
T
H
C
E
L
L
R
D
G
D
G
Y
Y
A
W
D
A
L
T
A
A
Y
V
-------------------------------------------------------------
26
PsiBlast_CBE
68.45
33%
-88
- C1 -
1HP0
2
?
B:
[15-280]
--
K
N
V
V
L
D
H
D
G
N
L
D
D
F
V
A
M
V
L
L
A
S
N
T
-
E
-
K
V
R
L
I
G
A
L
C
T
D
A
D
C
F
V
E
N
G
F
N
V
T
G
K
I
M
C
L
M
H
N
N
-
M
NLP
L
F
---
P
I
G
K
S
A
A
T
A
V
------
N
P
F
P
K
E
W
R
C
L
A
K
N
M
D
D
M
P
I
L
N
--------
I
P
E
N
V
E
L
W
D
K
I
K
A
E
-----
N
E
K
Y
E
G
Q
Q
L
L
A
D
L
V
M
N
---
S
E
E
K
V
T
I
C
V
T
G
P
L
S
N
V
A
W
C
I
D
K
Y
G
E
K
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
R
G
N
V
F
L
P
S
T
D
G
T
A
E
W
N
I
Y
W
D
P
A
S
A
K
T
V
F
G
C
P
G
-
L
R
R
I
M
F
S
L
D
S
T
N
T
V
P
V
-
R
S
P
Y
V
Q
R
F
G
E
Q
T
N
F
L
L
S
I
L
V
-
G
T
M
W
A
M
C
T
H
-----
D
G
D
G
Y
Y
A
W
D
A
L
T
A
A
Y
V
-------------------------------------------------------------
27
PsiBlast_CBE
68.22
33%
-85
- C1 -
3B9G
2
?
B:
[14-269]
--
K
N
V
V
L
D
H
D
G
N
L
D
D
F
V
A
M
V
L
L
A
S
N
T
-
E
-
K
V
R
L
I
G
A
L
C
T
D
A
D
C
F
V
E
N
G
F
N
V
T
G
K
I
M
C
L
M
H
N
N
-
M
NL
P
L
F
---
P
I
G
K
S
A
A
T
A
V
------
N
P
F
P
K
E
W
R
C
L
A
K
N
M
D
D
M
P
I
L
N
--------
I
P
E
N
V
E
L
W
D
K
I
K
A
E
-----
N
E
K
Y
E
G
Q
Q
L
L
A
D
L
V
M
N
---
S
E
E
K
V
T
I
C
V
T
G
P
L
S
N
V
A
W
C
I
D
K
Y
G
E
K
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
R
G
N
V
F
L
P
S
T
D
G
T
A
E
W
N
I
Y
W
D
P
A
S
A
K
T
V
F
G
C
P
G
-
L
R
R
I
M
F
S
L
D
S
T
N
T
V
P
V
-
R
S
P
Y
V
Q
R
F
G
E
Q
T
N
F
L
L
S
I
L
V
-
G
T
M
W
A
M
----------
G
G
G
Y
A
W
D
A
L
T
A
A
Y
V
-------------------------------------------------------------
25
PsiBlast_CBE
68.20
33%
-87
- C1 -
2FF1
2
?
B:
[15-280]
--
K
N
V
V
L
D
H
D
G
N
L
D
D
F
V
A
M
V
L
L
A
S
N
T
-
E
-
K
V
R
L
I
G
A
L
C
T
D
A
D
C
F
V
E
N
G
F
N
V
T
G
K
I
M
C
L
M
H
N
N
-
M
NL
P
L
F
---
P
I
G
K
S
A
A
T
A
V
------
N
P
F
P
K
E
W
R
C
L
A
K
N
M
D
D
M
P
I
L
N
--------
I
P
E
N
V
E
L
W
D
K
I
K
A
E
-----
N
E
K
Y
E
G
Q
Q
L
L
A
D
L
V
M
N
---
S
E
E
K
V
T
I
C
V
T
G
P
L
S
N
V
A
W
C
I
D
K
Y
G
E
K
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
R
G
N
V
F
L
P
S
T
D
G
T
A
E
W
N
I
Y
W
D
P
A
S
A
K
T
V
F
G
C
P
G
-
L
R
R
I
M
F
S
L
D
S
T
N
T
V
P
V
-
R
S
P
Y
V
Q
R
F
G
E
Q
T
N
F
L
L
S
I
L
V
-
G
T
M
W
A
M
-----------
G
Y
Y
A
W
D
A
L
T
A
A
Y
V
-------------------------------------------------------------
7
PsiBlast_PDB
68.10
33%
-86
- C1 -
3B9G
3
?
A:
[14-269]
--
K
N
V
V
L
D
H
D
G
N
L
D
D
F
V
A
M
V
L
L
A
S
N
T
-
E
-
K
V
R
L
I
G
A
L
C
T
D
A
D
C
F
V
E
N
G
F
N
V
T
G
K
I
M
C
L
M
H
N
N
-
M
NL
P
L
F
---
P
I
G
K
S
A
A
T
A
V
------
N
P
F
P
K
E
W
R
C
L
A
K
N
M
D
D
M
P
I
L
N
--------
I
P
E
N
V
E
L
W
D
K
I
K
A
E
-----
N
E
K
Y
E
G
Q
Q
L
L
A
D
L
V
M
N
---
S
E
E
K
V
T
I
C
V
T
G
P
L
S
N
V
A
W
C
I
D
K
Y
G
E
K
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
R
G
N
V
F
L
P
S
T
D
G
T
A
E
W
N
I
Y
W
D
P
A
S
A
K
T
V
F
G
C
P
G
-
L
R
R
I
M
F
S
L
D
S
T
N
T
V
P
V
-
R
S
P
Y
V
Q
R
F
G
E
Q
T
N
F
L
L
S
I
L
V
-
G
T
M
W
A
M
----------
G
G
G
Y
A
W
D
A
L
T
A
A
Y
V
-------------------------------------------------------------
6
PsiBlast_PDB
68.06
33%
-89
- C1 -
1KIC
5
?
A:
[15-280]
--
K
N
V
V
L
D
H
A
G
N
L
D
D
F
V
A
M
V
L
L
A
S
N
T
-
E
-
K
V
R
L
I
G
A
L
C
T
D
A
D
C
F
V
E
N
G
F
N
V
T
G
K
I
M
C
L
M
H
N
N
-
M
NL
P
L
F
---
P
I
G
K
S
A
A
T
A
V
------
N
P
F
P
K
E
W
R
C
L
A
K
N
M
D
D
M
P
I
L
N
--------
I
P
E
N
V
E
L
W
D
K
I
K
A
E
-----
N
E
K
Y
E
G
Q
Q
L
L
A
D
L
V
M
N
---
S
E
E
K
V
T
I
C
V
T
G
P
L
S
N
V
A
W
C
I
D
K
Y
G
E
K
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
R
G
N
V
F
L
P
S
T
D
G
T
A
E
W
N
I
Y
W
D
P
A
S
A
K
T
V
F
G
C
P
G
-
L
R
R
I
M
F
S
L
D
S
T
N
T
V
P
V
-
R
S
P
Y
V
Q
R
F
G
E
Q
T
N
F
L
L
S
I
L
V
-
G
T
M
W
A
M
C
T
----------
Y
Y
A
W
D
A
L
T
A
A
Y
V
-------------------------------------------------------------
8
PsiBlast_PDB
67.87
33%
-86
- C1 -
4I70
1
?
A:
[1-294]
M
A
K
T
V
I
L
D
H
D
G
N
K
D
D
F
V
A
M
I
L
L
L
S
-
N
P
K
-
K
V
N
L
I
G
C
I
C
T
D
A
D
C
F
V
E
N
G
F
D
V
T
G
K
I
M
C
A
M
H
R
-------
L
---
I
K
T
P
L
F
P
I
G
K
S
TATAV
N
A
F
P
T
E
W
R
F
S
A
K
N
L
D
D
M
P
F
L
N
I
V
E
D
V
A
L
W
E
K
--------
L
K
P
E
-----
N
E
A
H
N
G
Q
Q
L
L
A
D
L
V
M
---
K
S
K
E
K
V
T
V
C
V
T
G
P
L
S
N
M
A
W
C
I
E
K
Y
G
E
A
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
G
G
N
V
F
L
P
T
T
D
G
S
A
E
W
N
I
Y
W
D
P
P
A
A
K
K
V
L
C
C
P
N
-
I
R
C
V
L
F
S
L
D
A
T
N
T
V
P
V
R
S
V
D
V
K
G
-
F
G
A
Q
N
Q
Y
L
L
S
Q
M
V
-
G
T
M
W
A
M
-----------
A
Y
Y
A
W
D
A
L
T
A
A
Y
I
L
E
P
T
I
A
T
L
E
P
V
A
L
D
V
D
V
S
K
G
K
-
S
E
G
R
T
----------------------------------
32
PsiBlast_CBE
67.68
33%
-83
- C1 -
4I72
6
?
B:
[4-299]
M
A
K
T
V
I
L
D
H
D
G
N
K
D
D
F
V
A
M
I
L
L
L
S
-
N
P
K
-
K
V
N
L
I
G
C
I
C
T
D
A
D
C
F
V
E
N
G
F
D
V
T
G
K
I
M
C
A
M
H
R
-------
L
---
I
K
T
P
L
F
P
I
G
K
STATAV
N
A
F
P
T
E
W
R
F
S
A
K
N
L
D
D
M
P
F
L
N
IVEDVALW
E
K
--------
L
K
P
E
-----
N
E
A
H
N
G
Q
Q
L
L
A
D
L
V
M
---
K
S
K
E
K
V
T
V
C
V
T
G
P
L
S
N
M
A
W
C
I
E
K
Y
G
E
A
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
G
G
N
V
F
L
P
T
T
D
G
S
A
E
W
N
I
Y
W
D
P
P
A
A
K
K
V
L
C
C
P
N
-
I
R
C
V
L
F
S
L
D
A
T
N
T
V
P
V
R
S
V
D
V
K
G
-
F
G
A
Q
N
Q
Y
L
L
S
Q
M
V
-
G
T
M
W
A
M
S
T
H
E
E
I
L
R
D
G
D
A
Y
Y
A
W
D
A
L
T
A
A
Y
I
L
E
P
T
I
A
T
L
E
P
V
A
L
D
V
D
V
S
K
G
K
-
S
E
G
R
T
----------------------------------
11
PsiBlast_PDB
67.64
33%
-84
- C1 -
4I73
6
?
A:
[4-300]
M
A
K
T
V
I
L
D
H
D
G
N
K
D
D
F
V
A
M
I
L
L
L
S
-
N
P
K
-
K
V
N
L
I
G
C
I
C
T
D
A
D
C
F
V
E
N
G
F
D
V
T
G
K
I
M
C
A
M
H
R
-------
L
---
I
K
T
P
L
F
P
I
G
K
S
TATAV
N
A
F
P
T
E
W
R
F
S
A
K
N
L
D
D
M
P
F
L
N
I
V
E
D
V
A
L
W
E
K
--------
L
K
P
E
-----
N
E
A
H
N
G
Q
Q
L
L
A
D
L
V
M
---
K
S
K
E
K
V
T
V
C
V
T
G
P
L
S
N
M
A
W
C
I
E
K
Y
G
E
A
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
G
G
N
V
F
L
P
T
T
D
G
S
A
E
W
N
I
Y
W
D
P
P
A
A
K
K
V
L
C
C
P
N
-
I
R
C
V
L
F
S
L
D
A
T
N
T
V
P
V
R
S
V
D
V
K
G
-
F
G
A
Q
N
Q
Y
L
L
S
Q
M
V
-
G
T
M
W
A
M
S
T
H
E
E
I
L
R
D
G
D
A
Y
Y
A
W
D
A
L
T
A
A
Y
I
L
E
P
T
I
A
T
L
E
P
V
A
L
D
V
D
V
S
K
G
K
-
S
E
G
R
T
----------------------------------
10
PsiBlast_PDB
67.64
33%
-84
- C1 -
4I72
8
?
A:
[4-299]
M
A
K
T
V
I
L
D
H
D
G
N
K
D
D
F
V
A
M
I
L
L
L
S
-
N
P
K
-
K
V
N
L
I
G
C
I
C
T
D
A
D
C
F
V
E
N
G
F
D
V
T
G
K
I
M
C
A
M
H
R
-------
L
---
I
K
T
P
L
F
P
I
G
K
S
TATAV
N
A
F
P
T
E
W
R
F
S
A
K
N
L
D
D
M
P
F
L
N
I
V
E
D
V
A
L
W
E
K
--------
L
K
P
E
-----
N
E
A
H
N
G
Q
Q
L
L
A
D
L
V
M
---
K
S
K
E
K
V
T
V
C
V
T
G
P
L
S
N
M
A
W
C
I
E
K
Y
G
E
A
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
G
G
N
V
F
L
P
T
T
D
G
S
A
E
W
N
I
Y
W
D
P
P
A
A
K
K
V
L
C
C
P
N
-
I
R
C
V
L
F
S
L
D
A
T
N
T
V
P
V
R
S
V
D
V
K
G
-
F
G
A
Q
N
Q
Y
L
L
S
Q
M
V
-
G
T
M
W
A
M
S
T
H
E
E
I
L
R
D
G
D
A
Y
Y
A
W
D
A
L
T
A
A
Y
I
L
E
P
T
I
A
T
L
E
P
V
A
L
D
V
D
V
S
K
G
K
-
S
E
G
R
T
----------------------------------
13
PsiBlast_PDB
66.50
33%
-84
- C1 -
4I75
6
?
A:
[4-302]
M
A
K
T
V
I
L
D
H
D
G
N
K
D
D
F
V
A
M
I
L
L
L
S
-
N
P
K
-
K
V
N
L
I
G
C
I
C
T
D
A
D
C
F
V
E
N
G
F
D
V
T
G
K
I
M
C
A
M
H
R
-------
L
---
I
K
T
P
L
F
P
I
G
K
S
TATAV
N
A
F
P
T
E
W
R
F
S
A
K
N
L
D
D
M
P
F
L
N
I
V
E
D
V
A
L
W
E
K
--------
L
K
P
E
-----
N
E
A
H
N
G
Q
Q
L
L
A
D
L
V
M
---
K
S
K
E
K
V
T
V
C
V
T
G
P
L
S
N
M
A
W
C
I
E
K
Y
G
E
A
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
G
G
N
V
F
L
P
T
T
D
G
S
A
E
W
N
I
Y
W
D
P
P
A
A
K
K
V
L
C
C
P
N
-
I
R
C
V
L
F
S
L
D
A
T
N
T
V
P
V
R
S
V
D
V
K
G
-
F
G
A
Q
N
Q
Y
L
L
S
Q
M
V
-
G
T
M
W
A
M
S
T
H
E
E
I
L
R
D
G
D
A
Y
Y
A
W
D
A
L
T
A
A
Y
I
L
E
P
T
I
A
T
L
E
P
V
A
L
D
V
D
V
S
K
G
K
-
S
E
G
R
T
----------------------------------
30
PsiBlast_CBE
66.26
33%
-83
- C1 -
4I73
6
?
C:
[4-300]
M
A
K
T
V
I
L
D
H
D
G
N
K
D
D
F
V
A
M
I
L
L
L
S
-
N
P
K
-
K
V
N
L
I
G
C
I
C
T
D
A
D
C
F
V
E
N
G
F
D
V
T
G
K
I
M
C
A
M
H
R
-------
L
---
I
K
T
P
L
F
P
I
G
K
S
TATAV
N
A
F
P
T
E
W
R
F
S
A
K
N
L
D
D
M
P
F
L
N
I
V
E
D
V
A
L
W
E
K
--------
L
K
P
E
-----
N
E
A
H
N
G
Q
Q
L
L
A
D
L
V
M
---
K
S
K
E
K
V
T
V
C
V
T
G
P
L
S
N
M
A
W
C
I
E
K
Y
G
E
A
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
G
G
N
V
F
L
P
T
T
D
G
S
A
E
W
N
I
Y
W
D
P
P
A
A
K
K
V
L
C
C
P
N
-
I
R
C
V
L
F
S
L
D
A
T
N
T
V
P
V
R
S
V
D
V
K
G
-
F
G
A
Q
N
Q
Y
L
L
S
Q
M
V
-
G
T
M
W
A
M
S
T
---------
A
Y
Y
A
W
D
A
L
T
A
A
Y
I
L
E
P
T
I
A
T
L
E
P
V
A
L
D
V
D
V
S
K
G
K
-
S
E
G
R
T
----------------------------------
28
PsiBlast_CBE
66.12
33%
-83
- C1 -
4I75
9
?
B:
[4-302]
M
A
K
T
V
I
L
D
H
D
G
N
K
D
D
F
V
A
M
I
L
L
L
S
-
N
P
K
-
K
V
N
L
I
G
C
I
C
T
D
A
D
C
F
V
E
N
G
F
D
V
T
G
K
I
M
C
A
M
H
R
-------
L
---
I
K
T
P
L
F
P
I
G
K
S
TATAV
N
A
F
P
T
E
W
R
F
S
A
K
N
L
D
D
M
P
F
L
N
I
V
E
D
V
A
L
W
E
K
--------
L
K
P
E
-----
N
E
A
H
N
G
Q
Q
L
L
A
D
L
V
M
---
K
S
K
E
K
V
T
V
C
V
T
G
P
L
S
N
M
A
W
C
I
E
K
Y
G
E
A
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
G
G
N
V
F
L
P
T
T
D
G
S
A
E
W
N
I
Y
W
D
P
P
A
A
K
K
V
L
C
C
P
N
-
I
R
C
V
L
F
S
L
D
A
T
N
T
V
P
V
R
S
V
D
V
K
G
-
F
G
A
Q
N
Q
Y
L
L
S
Q
M
V
-
G
T
M
W
A
M
S
T
H
E
E
I
L
R
D
G
D
A
Y
Y
A
W
D
A
L
T
A
A
Y
I
L
E
P
T
I
A
T
L
E
P
V
A
L
D
V
D
V
S
K
G
K
-
S
E
G
R
T
----------------------------------
12
PsiBlast_PDB
66.00
33%
-82
- C1 -
4I74
7
?
A:
[4-300]
M
A
K
T
V
I
L
D
H
D
G
N
K
D
D
F
V
A
M
I
L
L
L
S
-
N
P
K
-
K
V
N
L
I
G
C
I
C
T
D
A
D
C
F
V
E
N
G
F
D
V
T
G
K
I
M
C
A
M
H
R
-------
L
---
I
K
T
P
L
F
P
I
G
K
S
TATAV
N
A
F
P
T
E
W
R
F
S
A
K
N
L
D
D
M
P
F
L
N
I
V
E
D
V
A
L
W
E
K
--------
L
K
P
E
-----
N
E
A
H
N
G
Q
Q
L
L
A
D
L
V
M
---
K
S
K
E
K
V
T
V
C
V
T
G
P
L
S
N
M
A
W
C
I
E
K
Y
G
E
A
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
G
G
N
V
F
L
P
T
T
D
G
S
A
E
W
N
I
Y
W
D
P
P
A
A
K
K
V
L
C
C
P
N
-
I
R
C
V
L
F
S
L
D
A
T
N
T
V
P
V
R
S
V
D
V
K
G
-
F
G
A
Q
N
Q
Y
L
L
S
Q
M
V
-
G
T
M
W
A
M
S
T
H
E
E
I
L
R
D
G
D
A
Y
Y
A
W
D
A
L
T
A
A
Y
I
L
E
P
T
I
A
T
L
E
P
V
A
L
D
V
D
V
S
K
G
K
-
S
E
G
R
T
----------------------------------
31
PsiBlast_CBE
65.79
33%
-83
- C1 -
4I73
4
?
B:
[4-300]
M
A
K
T
V
I
L
D
H
D
G
N
K
D
D
F
V
A
M
I
L
L
L
S
-
N
P
K
-
K
V
N
L
I
G
C
I
C
T
D
A
D
C
F
V
E
N
G
F
D
V
T
G
K
I
M
C
A
M
H
R
-------
L
---
I
K
T
P
L
F
P
I
G
K
S
TATAV
N
A
F
P
T
E
W
R
F
S
A
K
N
L
D
D
M
P
F
L
N
I
V
E
D
V
A
L
W
E
K
--------
L
K
P
E
-----
N
E
A
H
N
G
Q
Q
L
L
A
D
L
V
M
---
K
S
K
E
K
V
T
V
C
V
T
G
P
L
S
N
M
A
W
C
I
E
K
Y
G
E
A
-
F
T
S
K
V
E
E
C
V
I
M
G
G
A
V
D
V
G
G
N
V
F
L
P
T
T
D
G
S
A
E
W
N
I
Y
W
D
P
P
A
A
K
K
V
L
C
C
P
N
-
I
R
C
V
L
F
S
L
D
A
T
N
T
V
P
V
R
S
V
D
V
K
G
-
F
G
A
Q
N
Q
Y
L
L
S
Q
M
V
-
G
T
M
W
A
M
S
T
H
E
E
I
L
R
D
G
D
A
Y
Y
A
W
D
A
L
T
A
A
Y
I
L
E
P
T
I
A
T
L
E
P
V
A
L
D
V
D
V
S
K
G
K
-
S
E
G
R
T
----------------------------------