@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2102: (2016-04-01 )
MQEHLVVTLDGKDYLVEPGTNLLEFIKSQDTFVPSICYNESMGPIQTCDTCTVEIDGKIERSCSTVIDRPMTVNTVNNDVKDAQKEALDRILEKHMLYCTVCDYNNGDCEIHNTMDAWGLQHQTYEYKEKPYEKDYGPFYRYDPNQCILCGRCVEACQDIEVNETIRIDWDREHPRVIWDNDVPINESSCVSCGQCATVCPCNAMMEVNMEGNAGYMTDTEPGSLAAMIDLTKKAEPGYGPLFAISDSEAEMRKERIKKTKTVCTYCGVGCSFEVWTKDREILKVQPSHDSPANKIATCVKGKFSWGHINSDQRLTKPLVRKNGEFHEVEWDEALNVIADNFTSIKEKYGPDALSFISSSKATNEESYLMQKLARQVIGTNNVDNCSRYCQAPATKGLFRTVGHGGDSGSIEDLEKAAMSVLIGTNTAEAHPVIASRMKRAQKLFGQKIHVFDIRKHEMAERADRFYQPKPGTDLAWLSAVTKYIIDHDLHDKAFIDEWVDDFDEYYKSLETFTMAFAEEATGIPESELIKFAEECAKAESVVICWAMGITQQDIGSDSSTAISNLLLVTGNYRRPGTGAYPLRGHNNVQGCSDMGSMPDKITGYQSIEADDIRAKFEKEYGVKLNPKAGKDNHEMVEGIHDGEVHSLYLYGEDTGIVDSNINFVQAAFEKLDFMVVQDEFLTFTATYADVVLPASPSLEKDGTFTNTERRIQRLYQALEPLGDSKPDWKIFQAIANRLGFDWNYKHPSEIMDEVARLTPLYAGVSYDRLEGFNSLQWPVQPDGTDEPILYLEGFNFDNGKAKLFPLSFDNYFKQDEIYDIHVNNGRLLEHFHEGNMTYQTPMIKYKVPRAFVEISPELAEDRGIHEGAEVKLISETGEAVLQVHVTDRVKGKEIYIPLNNDAMENGDLGAINLLTNSDVDQYTDTPSYKRTSCRLEVITKRGKSPLNPNNFRVNKKRHPQYSVQVQKKWERSDYVFPGNQVDK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.-.....--.270.......280-----------------------------------------.......-------..290..-------.....300.......310----.-----.......320------.----.--------------------------------------......330.......340-.......350.....----..----360.......370.......380....-----.-..390.---......400.......410--.......420.......-430....--.-----------...---440----------...-.-...-----..--450.......460.--------...--------...470.......480......------.490.......500---------------------------------------------------------------------.---------....-----------------------------------------------------------------------------------------------------------------------------------------------------------...510.......520.......530.......------540------...-.-.-...550....--....560.....--..570......------------.580...-------------.------------...-590.-.-.....---------600..----..-----------------....-.610---....-...------------..620--...---.---.---.----------------------.---.----------.630.-....----------..640-------------...---.....650.......660-----------------------------..--.-..--..-------------------------------.670--..----.-......680--..-.....690.......700......---.710--........720......-.730.......740---------------.------.---------------..-----------------------...----------750----------------------------------..-----------.---.------..---..-------------760-----------------------.------------.--------.----..-----------------------------------------------------....----------------770------------------.-----.---------------------------.------------------------------..--....780-----------..--..-...-----..----------790--------------.---..---------------..-------------.---..800.......------------810----------.------.----.----.-------------.------------....820.......830.......840......-.850.......860.......870......--.--880.......--..890..--.....900.------...------.--------..910......-.920..---....--------------..----------------930.......940.......950.......960.......970.......980..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQE
H
L
V
V
T
LDGK
D
Y
L
VEP
G
T
N
L
L
E
F
I
KSQDTFV
P
S
I
CYNESMGPIQTC
D
T
C
T
V
E
IDG
K
I
E
R
S
C
S
T
VIDRP
M
T
V
NTVN
N
D
V
K
D
A
Q
K
E
A
L
D
R
I
L
E
KH
M
L
Y
C
T
V
C
DYNNG
D
C
E
I
HNT
M
D
A
WGLQHQT
Y
E
YKEKPYEKDYGPFYRYDP
N
Q
C
I
L
C
G
R
C
V
E
A
C
QDIEVN
E
T
I
R
I
D
WDREH
P
R
V
I
WDNDVPINESSCVSCGQ
C
A
TVCPCN
A
M
M
E
V
NMEGNA
G
Y
MTDTEPG
S
L
A
A
M
I
D
LTKKAEPGYG
P
L
F
A
ISD
S
E
A
E
M
R
K
E
R
I
K
K
T
K
T
V
-
C
T
YCG--VGC
S
F
E
V
W
TKD
R
-------------------------------------------
E
I
L
K
VQP-------SHDS
P
A
N
-------
K
I
A
T
C
VKGKFSWGHINS-----
D
-----
Q
R
L
T
K
P
L
V
R-------K----N--------------------------------------GEFHEV
E
W
D
E
A
L
N
V
I
A
D
N
F
-
T
S
I
K
E
KYG
P
D
A
L
S
F
I
----SS----SKAT
N
E
E
S
Y
L
M
Q
K
L
A
R
Q
V
IGTN
N
V
D
N
C
-----
S
-
R
Y
C
QAP---AT
K
G
L
F
R
T
VGHGGDSG
S
I
E
--
D
L
E
K
A
A
M
S
V
L
I
GTNTAE-A-H
P
V
I
A
--
S
-----------
R
M
K
---
R
------------
A
Q
K
-
L
-FG
Q
-----
K
I
--
H
V
F
D
I
R
K
H
E
M
A
E
R
A
--------
D
RF--------YQPKPGT
D
L
A
W
L
S
A
V
T
K
Y
I
IDH------DLH
D
K
A
F
I
D
E
W
V
D
----------------------------------------------------------------------
D
---------
F
D
E
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
S
L
E
T
F
T
M
A
F
A
E
E
ATGI
P
E
S
E
L
I
K
F
A
E
E
CAKA------E-
S
------
V
V
I
-
C
-
W
-AMGI-
T
Q
Q
DI--GSD
S
S
T
A
I
S
N
L
L
--
L
V
TGNYRRPGT------------GAYPLRG-------------H------------NNV-QG
C
S
-
D
-MGSMP---------D--KI----TG-----------------YQSI-
E
A
-----
D
D
I
R
-
A
K
F
------------
E
K
E----YG
V
---
K
---L---N----------------------P---K----------AGKD
N
-
H
E
M
V
----------
E
GIH--------------DG
E
---
V
H
S
L
Y
L
YGEDTGIVDSN------------------------------
I
N
--
F
-
V
Q
--
A
A
-------------------------------
F
E
----KL----
D
-
F
M
V
V
QD
E
F
L
--
T
F
-
T
A
T
Y
A
D
V
VLPASPSLEKDGTFT
N
T
---
E
R
R
---
I
Q
R
L
Y
Q
A
L
E
PLGDSKP
D
-
W
K
I
F
Q
A
I
A
N
RLGFD---------------W------N---------------YK-----------------------
H
P
S
----------
E
I
-----------------------------------
M
D
-----------
E
---
V
------
A
R
---
L
T
-------------
P
-------------------------
L
------------Y--------A----GV-----------------------------------------------------
S
Y
D
R
----------------L--------------------E-----G---------------------------F------------------------------NS--LQWPV-------------QP--DG-TDE-----
P
I
----------
L
Y
---------------
L
---EG---------------FN-------------F---DNG
K
A
K
L
F
P
L
S
F
------------D------------N------Y----F----K-------------Q------------D
E
I
Y
D
I
HVNN
G
R
L
L
E
H
F
HEGN
M
T
Y
QT
P
M
I
K
Y
KV-P
R
A
F
V
EI
S
P
E
L
A
EDRGIHEGA
E
V
K
L
I
SETG--
E
--
A
--
V
L
Q
V
H
V
T--DRVKG
K
E
--
I
Y
I
PLNNDA------MEN------G--------DL
G
A
I
N
L
LTNS-D
V
-
D
QY---TDTP--------------SY----------------KRT
S
C
R
L
E
V
I
TKRGKSPLNPNNFRVNKKRHPQ
Y
S
V
Q
V
Q
K
KWERS
D
Y
VFPGNQVDK
49
HHSearch
93.24
29%
-41
* C1 *
2NAP
5
NAPA_DESDA
A:
[4-723]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
E
K
W
V
K
G
V
-
C
R
Y
C
G
--
T
G
C
G
V
L
V
G
V
K
D
G
-------------------------------------------
K
A
V
A
I
Q
G
-------
N
P
N
N
-
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
V
L
N
S
-----
K
-----
E
R
V
T
Q
P
L
V
R
-------
R
HK--
G
--------------------------------------
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
-
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
-
R
L
C
M
A
S
---
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
--
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
-
H
P
V
L
F
--
R
-----------
R
I
A
---
R
------------
R
K
Q
V
E
-
P
G
V
-----
K
I
--
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
------
E
L
D
N
P
R
F
W
Q
R
Y
V
N
----------------------------------------------------------------------
F
M
D
AEGKPSD
F
E
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
A
E
S
------
A
-
A
------
T
M
S
-
L
-
W
-
C
M
G
I
-
N
Q
R
V
Q
--
G
V
F
A
N
N
L
I
H
N
L
H
--
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
-------------
Q
------------
P
N
A
-
C
G
G
V
R
D
-
G
G
A
L
S
---------
H
--
L
L
----
P
A
-----------------
G
R
A
I
-
P
N
-----
A
K
H
R
-
A
E
M
------------
E
K
L
----
W
G
L
---
P
---
E
GRI
A
----------------------
P
---
E
----------
P
G
Y
H
T
-
V
A
L
F
----------
E
A
L
G
--------------
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
N
--
K
-
V
H
--
K
A
-------------------------------
M
S
----
H
P
E---
S
-
F
I
V
C
I
E
A
F
P
--
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
---
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
L
V
E
F
A
R
R
A
G
V
D
---------------
P
QLV---
N
---------------
F
R
-----------------------
N
A
E
----------
D
V
-----------------------------------
W
N
-----------
E
---
W
------
R
M
---
V
S
KGTT---------
Y
-------------------------
D
------------
F
--------
W
----
G
M
-----------------------------------------------------
T
R
E
R
----------------
L
--------------------
R
K
E
S--
G
---------------------------
L
------------------------------
I
W
--
P
C
P
S
E
-------------
D
H
--
P
---
G
T
-----
S
L
----------
R
Y
VRGQDPCVPADH---
P
DRF
F
F
---------------
Y
G
-------------
K
---
P
D
G
R
A
V
I
W
M
R
P
A
------------
K
------------
G
------
A
----
A
E
---
E
-------------
P
------------
D
A
E
Y
P
L
Y
L
T
S
M
R
V
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
-
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
--
A
--
M
--
E
L
P
A
R
V
S
--
D
V
C
R
P
G
L
--
I
A
V
P
F
F
D
P
--------------------------
K
K
L
V
N
K
L
F
L
D
-
A
T
-
D
P
V
---
S
R
E
P
--------------
E
Y
----------------
K
I
C
A
A
R
V
R
K
A
---------------------------------------------
8
PsiBlast_PDB
93.15
28%
-47
- C1 -
2V3V
9
NAPA_DESDA
A:
[7-721]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
K
G
V
-
C
R
Y
C
G
--
T
G
C
G
V
L
V
G
V
K
D
G
-------------------------------------------
K
A
V
A
I
Q
G
-------
D
P
N
N
-
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
V
L
N
S
-----
K
-----
E
R
V
T
Q
P
L
V
R
RH-----
K
----
G
--------------------------------------
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
-
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
-
R
L
C
M
A
S
---
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
--
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
-
H
P
V
L
F
--
R
-----------
R
I
A
---
R
------------
R
K
Q
-
V
E
P
G
V
-----
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I
--
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
------
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEGKPS-------------------------------------------------------------
D
---------
F
E
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
A
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------
A
-
A
------
T
M
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L
-
W
-
C
M
G
I
-
N
Q
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V
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--
G
V
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A
N
N
L
I
H
N
L
H
--
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
-------------
Q
------------
P
N
A
C
G
G
V
R
-
D
-
G
G
A
L
S
---------
H
--
L
L
----
P
A
-----------------
G
R
A
I
-
P
N
-----
A
K
H
R
-
A
E
M
------------
E
K
L
----
W
G
L
PEG
R
---
I
---
A
----------------------
P
---
E
----------
P
G
Y
H
T
-
V
A
L
F
----------
E
A
L
G
--------------
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
N
--
K
-
V
H
--
K
A
-------------------------------
M
S
----
H
P
----
E
-
S
F
I
V
C
I
E
A
F
PD
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
---
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
L
V
E
F
A
R
R
A
G
V
D
PQL------------
V
------
N
---------------
F
R
-----------------------
N
A
E
----------
D
V
-----------------------------------
W
N
-----------
E
W
R
M
V
------
S
K
---
G
T
-------------
T
-------------------------
Y
D-----------
F
--------
W
----
G
M
-----------------------------------------------------
T
R
E
R
----------------
L
--------------------
R
-----
K
---------------------------
E
------------------------------
S
G
--
L
I
W
P
C
P------------
S
E
--
D
H
-
P
G
T
-----
S
L
----------
R
Y
---------------
V
---
R
G
QDPCVPADHPDRFFF
Y
G
-------------
K
---
P
D
G
R
A
V
I
W
M
R
P
A
------------
K
------------
G
------
A
----
A
----
E
-------------
E
P
-----------
D
A
E
Y
P
L
Y
L
T
S
M
R
V
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
-
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
--
A
--
M
--
E
L
P
A
R
V
S
--
D
V
C
R
P
G
L
--
I
A
V
P
F
F
D
P
K
------
K
--------------------
L
V
N
K
L
F
L
D
-
A
T
-
D
P
V
---
S
R
E
P
--------------
E
Y
----------------
K
I
C
A
A
R
V
R
-----------------------------------------------
5
PsiBlast_PDB
92.85
28%
-46
- C1 -
2V45
6
NAPA_DESDA
A:
[7-721]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
K
G
V
-
C
R
Y
C
G
--
T
G
C
G
V
L
V
G
V
K
D
G
-------------------------------------------
K
A
V
A
I
Q
G
-------
N
P
N
N
-
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
V
L
N
S
-----
K
-----
E
R
V
T
Q
P
L
V
R
RH-----
K
----
G
--------------------------------------
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
-
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
-
R
L
C
M
A
S
---
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
--
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
-
H
P
V
L
F
--
R
-----------
R
I
A
---
R
------------
R
K
Q
-
V
E
P
G
V
-----
K
I
--
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
------
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEGKPS-------------------------------------------------------------
D
---------
F
E
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
A
E
S
------
A
-
A
------
T
M
S
-
L
-
W
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C
M
G
I
-
N
Q
R
V
Q
--
G
V
F
A
N
N
L
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H
N
L
H
--
L
I
T
G
Q
I
C
R
P
G
A
------------
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S
F
S
L
T
G
-------------
Q
------------
P
N
A
C
G
G
V
R
-
D
-
G
G
A
L
S
---------
H
--
L
L
----
P
A
-----------------
G
R
A
I
-
P
N
-----
A
K
H
R
-
A
E
M
------------
E
K
L
----
W
G
L
PEG
R
---
I
---
A
----------------------
P
---
E
----------
P
G
Y
H
T
-
V
A
L
F
----------
E
A
L
G
--------------
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
N
--
K
-
V
H
--
K
A
-------------------------------
M
S
----
H
P
----
E
-
S
F
I
V
C
I
E
A
F
PD
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
---
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
L
V
E
F
A
R
R
A
G
V
D
PQL------------
V
------
N
---------------
F
R
-----------------------
N
A
E
----------
D
V
-----------------------------------
W
N
-----------
E
W
R
M
V
------
S
K
---
G
T
-------------
T
-------------------------
Y
D-----------
F
--------
W
----
G
M
-----------------------------------------------------
T
R
E
R
----------------
L
--------------------
R
-----
K
---------------------------
E
------------------------------
S
G
--
L
I
W
P
C
P------------
S
E
--
D
H
-
P
G
T
-----
S
L
----------
R
Y
---------------
V
---
R
G
QDPCVPADHPDRFFF
Y
G
-------------
K
---
P
D
G
R
A
V
I
W
M
R
P
A
------------
K
------------
G
------
A
----
A
----
E
-------------
E
P
-----------
D
A
E
Y
P
L
Y
L
T
S
M
R
V
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
-
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
--
A
--
M
--
E
L
P
A
R
V
S
--
D
V
C
R
P
G
L
--
I
A
V
P
F
F
D
P
K
------
K
--------------------
L
V
N
K
L
F
L
D
-
A
T
-
D
P
V
---
S
R
E
P
--------------
E
Y
----------------
K
I
C
A
A
R
V
R
-----------------------------------------------
7
PsiBlast_PDB
92.73
28%
-45
- C1 -
2JIQ
12
NAPA_DESDA
A:
[7-721]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
K
G
V
-
C
R
Y
C
G
--
T
G
C
G
V
L
V
G
V
K
D
G
-------------------------------------------
K
A
V
A
I
Q
G
-------
D
P
N
N
-
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
V
L
N
S
-----
K
-----
E
R
V
T
Q
P
L
V
R
RH-----
K
----
G
--------------------------------------
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
-
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
-
R
L
C
M
A
S
---
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
--
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
-
H
P
V
L
F
--
R
-----------
R
I
A
---
R
------------
R
K
Q
-
V
E
P
G
V
-----
K
I
--
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
------
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEGKPS-------------------------------------------------------------
D
---------
F
E
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
A
E
S
------
A
-
A
------
T
M
S
-
L
-
W
-
C
M
G
I
-
N
Q
R
V
Q
--
G
V
F
A
N
N
L
I
H
N
L
H
--
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
-------------
Q
------------
P
N
A
C
G
G
V
R
-
D
-
G
G
A
L
S
---------
H
--
L
L
----
P
A
-----------------
G
R
A
I
-
P
N
-----
A
K
H
R
-
A
E
M
------------
E
K
L
----
W
G
L
PEG
R
---
I
---
A
----------------------
P
---
E
----------
P
G
Y
H
T
-
V
A
L
F
----------
E
A
L
G
--------------
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
N
--
K
-
V
H
--
K
A
-------------------------------
M
S
----
H
P
----
E
-
S
F
I
V
C
I
E
A
F
PD
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
---
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
L
V
E
F
A
R
R
A
G
V
D
PQL------------
V
------
N
---------------
F
R
-----------------------
N
A
E
----------
D
V
-----------------------------------
W
N
-----------
E
W
R
M
V
------
S
K
---
G
T
-------------
T
-------------------------
Y
D-----------
F
--------
W
----
G
M
-----------------------------------------------------
T
R
E
R
----------------
L
--------------------
R
-----
K
---------------------------
E
------------------------------
S
G
--
L
I
W
P
C
P------------
S
E
--
D
H
-
P
G
T
-----
S
L
----------
R
Y
---------------
V
---
R
G
QDPCVPADHPDRFFF
Y
G
-------------
K
---
P
D
G
R
A
V
I
W
M
R
P
A
------------
K
------------
G
------
A
----
A
----
E
-------------
E
P
-----------
D
A
E
Y
P
L
Y
L
T
S
M
R
V
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
-
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
--
A
--
M
--
E
L
P
A
R
V
S
--
D
V
C
R
P
G
L
--
I
A
V
P
F
F
D
P
K
------
K
--------------------
L
V
N
K
L
F
L
D
-
A
T
-
D
P
V
---
S
R
E
P
--------------
E
Y
----------------
K
I
C
A
A
R
V
R
-----------------------------------------------
1
PsiBlast_PDB
92.50
28%
-46
- C1 -
2NAP
5
NAPA_DESDA
A:
[7-721]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
K
G
V
-
C
R
Y
C
G
--
T
G
C
G
V
L
V
G
V
K
D
G
-------------------------------------------
K
A
V
A
I
Q
G
-------
N
P
N
N
-
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
V
L
N
S
-----
K
-----
E
R
V
T
Q
P
L
V
R
RH-----
K
----
G
--------------------------------------
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
-
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
-
R
L
C
M
A
S
---
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
--
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
-
H
P
V
L
F
--
R
-----------
R
I
A
---
R
------------
R
K
Q
-
V
E
P
G
V
-----
K
I
--
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
------
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEGKPS-------------------------------------------------------------
D
---------
F
E
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
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A
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S
------
A
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A
------
T
M
S
-
L
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M
G
I
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N
Q
R
V
Q
--
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V
F
A
N
N
L
I
H
N
L
H
--
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I
T
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Q
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C
R
P
G
A
------------
T
S
F
S
L
T
G
-------------
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------------
P
N
A
C
G
G
V
R
-
D
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G
G
A
L
S
---------
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--
L
L
----
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A
-----------------
G
R
A
I
-
P
N
-----
A
K
H
R
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A
E
M
------------
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K
L
----
W
G
L
PEG
R
---
I
---
A
----------------------
P
---
E
----------
P
G
Y
H
T
-
V
A
L
F
----------
E
A
L
G
--------------
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
N
--
K
-
V
H
--
K
A
-------------------------------
M
S
----
H
P
----
E
-
S
F
I
V
C
I
E
A
F
PD
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
---
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
L
V
E
F
A
R
R
A
G
V
D
PQL------------
V
------
N
---------------
F
R
-----------------------
N
A
E
----------
D
V
-----------------------------------
W
N
-----------
E
W
R
M
V
------
S
K
---
G
T
-------------
T
-------------------------
Y
D-----------
F
--------
W
----
G
M
-----------------------------------------------------
T
R
E
R
----------------
L
--------------------
R
-----
K
---------------------------
E
------------------------------
S
G
--
L
I
W
P
C
P------------
S
E
--
D
H
-
P
G
T
-----
S
L
----------
R
Y
---------------
V
---
R
G
QDPCVPADHPDRFFF
Y
G
-------------
K
---
P
D
G
R
A
V
I
W
M
R
P
A
------------
K
------------
G
------
A
----
A
----
E
-------------
E
P
-----------
D
A
E
Y
P
L
Y
L
T
S
M
R
V
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
-
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
--
A
--
M
--
E
L
P
A
R
V
S
--
D
V
C
R
P
G
L
--
I
A
V
P
F
F
D
P
K
------
K
--------------------
L
V
N
K
L
F
L
D
-
A
T
-
D
P
V
---
S
R
E
P
--------------
E
Y
----------------
K
I
C
A
A
R
V
R
-----------------------------------------------
6
PsiBlast_PDB
92.44
28%
-46
- C1 -
2JIO
5
NAPA_DESDA
A:
[7-721]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
K
G
V
-
C
R
Y
C
G
--
T
G
C
G
V
L
V
G
V
K
D
G
-------------------------------------------
K
A
V
A
I
Q
G
-------
D
P
N
N
-
H
N
-------
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L
L
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L
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S
-----
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-----
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L
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RH-----
K
----
G
--------------------------------------
G
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----
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----
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V
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K
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K
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G
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T
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N
V
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N
-----
P
-
R
L
C
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A
S
---
A
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Y
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K
D
E
P
M
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T
Y
A
--
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L
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--
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R
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A
---
R
------------
R
K
Q
-
V
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-----
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--
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T
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--------
D
M
H
--------
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A
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P
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T
D
L
A
F
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H
S
M
A
W
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I
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N
E
------
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEG
K
P
S
-------------------------------------------------------------
D
---------
F
E
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
A
E
S
------
A
-
A
------
T
M
S
-
L
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W
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C
M
G
I
-
N
Q
R
V
Q
--
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V
F
A
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H
N
L
H
--
L
I
T
G
Q
I
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R
P
G
A
------------
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S
F
S
L
T
G
-------------
Q
------------
P
N
A
C
G
G
V
R
-
D
-
G
G
A
L
S
---------
H
--
L
L
----
P
A
-----------------
G
R
A
I
-
P
N
-----
A
K
H
R
-
A
E
M
------------
E
K
L
----
W
G
L
PEG
R
---
I
---
A
----------------------
P
---
E
----------
P
G
Y
H
T
-
V
A
L
F
----------
E
A
L
G
--------------
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
N
--
K
-
V
H
--
K
A
-------------------------------
M
S
----
H
P
----
E
-
S
F
I
V
C
I
E
A
F
PD
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
---
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
L
V
E
F
A
R
R
A
G
V
D
PQL------------
V
------
N
---------------
F
R
-----------------------
N
A
E
----------
D
V
-----------------------------------
W
N
-----------
E
W
R
M
V
------
S
K
---
G
T
-------------
T
-------------------------
Y
D-----------
F
--------
W
----
G
M
-----------------------------------------------------
T
R
E
R
----------------
L
--------------------
R
-----
K
---------------------------
E
------------------------------
S
G
--
L
I
W
P
C
P------------
S
E
--
D
H
-
P
G
T
-----
S
L
----------
R
Y
---------------
V
---
R
G
QDPCVPADHPDRFFF
Y
G
-------------
K
---
P
D
G
R
A
V
I
W
M
R
P
A
------------
K
------------
G
------
A
----
A
----
E
-------------
E
P
-----------
D
A
E
Y
P
L
Y
L
T
S
M
R
V
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
-
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
--
A
--
M
--
E
L
P
A
R
V
S
--
D
V
C
R
P
G
L
--
I
A
V
P
F
F
D
P
K
------
K
--------------------
L
V
N
K
L
F
L
D
-
A
T
-
D
P
V
---
S
R
E
P
--------------
E
Y
----------------
K
I
C
A
A
R
V
R
-----------------------------------------------
4
PsiBlast_PDB
92.20
28%
-46
- C1 -
2JIR
6
NAPA_DESDA
A:
[7-721]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
K
G
V
-
C
R
Y
C
G
--
T
G
C
G
V
L
V
G
V
K
D
G
-------------------------------------------
K
A
V
A
I
Q
G
-------
N
P
N
N
-
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
V
L
N
S
-----
K
-----
E
R
V
T
Q
P
L
V
R
RH-----
K
----
G
--------------------------------------
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
-
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
-
R
L
C
M
A
S
---
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
--
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
-
H
P
V
L
F
--
R
-----------
R
I
A
---
R
------------
R
K
Q
-
V
E
P
G
V
-----
K
I
--
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
------
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEGKPS-------------------------------------------------------------
D
---------
F
E
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
A
E
S
------
A
-
A
------
T
M
S
-
L
-
W
-
C
M
G
I
-
N
Q
R
V
Q
--
G
V
F
A
N
N
L
I
H
N
L
H
--
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
-------------
Q
------------
P
N
A
C
G
G
V
R
-
D
-
G
G
A
L
S
---------
H
--
L
L
----
P
A
-----------------
G
R
A
I
-
P
N
-----
A
K
H
R
-
A
E
M
------------
E
K
L
----
W
G
L
PEG
R
---
I
---
A
----------------------
P
---
E
----------
P
G
Y
H
T
-
V
A
L
F
----------
E
A
L
G
--------------
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
N
--
K
-
V
H
--
K
A
-------------------------------
M
S
----
H
P
----
E
-
S
F
I
V
C
I
E
A
F
PD
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
---
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
L
V
E
F
A
R
R
A
G
V
D
PQL------------
V
------
N
---------------
F
R
-----------------------
N
A
E
----------
D
V
-----------------------------------
W
N
-----------
E
W
R
M
V
------
S
K
---
G
T
-------------
T
-------------------------
Y
D-----------
F
--------
W
----
G
M
-----------------------------------------------------
T
R
E
R
----------------
L
--------------------
R
-----
K
---------------------------
E
------------------------------
S
G
--
L
I
W
P
C
P------------
S
E
--
D
H
-
P
G
T
-----
S
L
----------
R
Y
---------------
V
---
R
G
QDPCVPADHPDRFFF
Y
G
-------------
K
---
P
D
G
R
A
V
I
W
M
R
P
A
------------
K
------------
G
------
A
----
A
----
E
-------------
E
P
-----------
D
A
E
Y
P
L
Y
L
T
S
M
R
V
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
-
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
--
A
--
M
--
E
L
P
A
R
V
S
--
D
V
C
R
P
G
L
--
I
A
V
P
F
F
D
P
K
------
K
--------------------
L
V
N
K
L
F
L
D
-
A
T
-
D
P
V
---
S
R
E
P
--------------
E
Y
----------------
K
I
C
A
A
R
V
R
-----------------------------------------------
3
PsiBlast_PDB
91.99
28%
-46
- C1 -
2JIP
5
NAPA_DESDA
A:
[7-721]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
K
G
V
-
C
R
Y
C
G
--
T
G
C
G
V
L
V
G
V
K
D
G
-------------------------------------------
K
A
V
A
I
Q
G
-------
N
P
N
N
-
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
V
L
N
S
-----
K
-----
E
R
V
T
Q
P
L
V
R
RH-----
K
----
G
--------------------------------------
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
-
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
-
R
L
C
M
A
S
---
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
--
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
-
H
P
V
L
F
--
R
-----------
R
I
A
---
R
------------
R
K
Q
-
V
E
P
G
V
-----
K
I
--
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
------
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEGKPS-------------------------------------------------------------
D
---------
F
E
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
A
E
S
------
A
-
A
------
T
M
S
-
L
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W
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C
M
G
I
-
N
Q
R
V
Q
--
G
V
F
A
N
N
L
I
H
N
L
H
--
L
I
T
G
Q
I
C
R
P
G
A
------------
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S
F
S
L
T
G
-------------
Q
------------
P
N
A
C
G
G
V
R
-
D
-
G
G
A
L
S
---------
H
--
L
L
----
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A
-----------------
G
R
A
I
-
P
N
-----
A
K
H
R
-
A
E
M
------------
E
K
L
----
W
G
L
PEG
R
---
I
---
A
----------------------
P
---
E
----------
P
G
Y
H
T
-
V
A
L
F
----------
E
A
L
G
--------------
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
N
--
K
-
V
H
--
K
A
-------------------------------
M
S
----
H
P
----
E
-
S
F
I
V
C
I
E
A
F
PD
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
---
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
L
V
E
F
A
R
R
A
G
V
D
PQL------------
V
------
N
---------------
F
R
-----------------------
N
A
E
----------
D
V
-----------------------------------
W
N
-----------
E
W
R
M
V
------
S
K
---
G
T
-------------
T
-------------------------
Y
D-----------
F
--------
W
----
G
M
-----------------------------------------------------
T
R
E
R
----------------
L
--------------------
R
-----
K
---------------------------
E
------------------------------
S
G
--
L
I
W
P
C
P------------
S
E
--
D
H
-
P
G
T
-----
S
L
----------
R
Y
---------------
V
---
R
G
QDPCVPADHPDRFFF
Y
G
-------------
K
---
P
D
G
R
A
V
I
W
M
R
P
A
------------
K
------------
G
------
A
----
A
----
E
-------------
E
P
-----------
D
A
E
Y
P
L
Y
L
T
S
M
R
V
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
-
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
--
A
--
M
--
E
L
P
A
R
V
S
--
D
V
C
R
P
G
L
--
I
A
V
P
F
F
D
P
K
------
K
--------------------
L
V
N
K
L
F
L
D
-
A
T
-
D
P
V
---
S
R
E
P
--------------
E
Y
----------------
K
I
C
A
A
R
V
R
-----------------------------------------------
2
PsiBlast_PDB
91.54
28%
-44
- C1 -
2JIM
5
NAPA_DESDA
A:
[7-721]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
K
G
V
-
C
R
Y
C
G
--
T
G
C
G
V
L
V
G
V
K
D
G
-------------------------------------------
K
A
V
A
I
Q
G
-------
N
P
N
N
-
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
V
L
N
S
-----
K
-----
E
R
V
T
Q
P
L
V
R
RH-----
K
----
G
--------------------------------------
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
-
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
-
R
L
C
M
A
S
---
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
--
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
-
H
P
V
L
F
--
R
-----------
R
I
A
---
R
------------
R
K
Q
-
V
E
P
G
V
-----
K
I
--
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
------
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEG
K
P
S
-------------------------------------------------------------
D
---------
F
E
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
A
E
S
------
A
-
A
------
T
M
S
-
L
-
W
-
C
M
G
I
-
N
Q
R
V
Q
--
G
V
F
A
N
N
L
I
H
N
L
H
--
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
-------------
Q
------------
P
N
A
C
G
G
V
R
-
D
-
G
G
A
L
S
---------
H
--
L
L
----
P
A
-----------------
G
R
A
I
-
P
N
-----
A
K
H
R
-
A
E
M
------------
E
K
L
----
W
G
L
PEG
R
---
I
---
A
----------------------
P
---
E
----------
P
G
Y
H
T
-
V
A
L
F
----------
E
A
L
G
--------------
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
N
--
K
-
V
H
--
K
A
-------------------------------
M
S
----
H
P
----
E
-
S
F
I
V
C
I
E
A
F
PD
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
---
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
L
V
E
F
A
R
R
A
G
V
D
PQL------------
V
------
N
---------------
F
R
-----------------------
N
A
E
----------
D
V
-----------------------------------
W
N
-----------
E
W
R
M
V
------
S
K
---
G
T
-------------
T
-------------------------
Y
D-----------
F
--------
W
----
G
M
-----------------------------------------------------
T
R
E
R
----------------
L
--------------------
R
-----
K
---------------------------
E
------------------------------
S
G
--
L
I
W
P
C
P------------
S
E
--
D
H
-
P
G
T
-----
S
L
----------
R
Y
---------------
V
---
R
G
QDPCVPADHPDRFFF
Y
G
-------------
K
---
P
D
G
R
A
V
I
W
M
R
P
A
------------
K
------------
G
------
A
----
A
----
E
-------------
E
P
-----------
D
A
E
Y
P
L
Y
L
T
S
M
R
V
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
-
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
--
A
--
M
--
E
L
P
A
R
V
S
--
D
V
C
R
P
G
L
--
I
A
V
P
F
F
D
P
K
------
K
--------------------
L
V
N
K
L
F
L
D
-
A
T
-
D
P
V
---
S
R
E
P
--------------
E
Y
----------------
K
I
C
A
A
R
V
R
-----------------------------------------------
9
PsiBlast_PDB
90.82
26%
-37
- C1 -
2NYA
4
NAPA_ECOLI
A:
[1-791]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
I
K
W
D
K
A
P
-
C
R
F
C
G
--
T
G
C
G
V
L
V
G
T
Q
Q
G
-------------------------------------------
R
V
V
A
C
Q
G
-------
D
P
D
A
P
V
N
-------
R
G
L
N
C
I
K
G
Y
F
L
P
K
I
M
Y
G
-----
K
-----
D
R
L
T
Q
P
L
L
R
MKNGKYD
K
----
E
--------------------------------------
G
E
F
T
P
I
T
W
D
Q
A
F
D
V
M
E
E
K
F
K
T
A
L
K
E
K
-
G
P
E
S
I
G
M
F
----
G
S
----
G
Q
W
T
I
W
E
G
Y
A
A
S
K
L
F
K
A
G
F
R
S
N
N
I
D
P
N
-----
A
-
R
H
C
M
A
S
---
A
V
V
G
F
M
R
T
F
G
M
D
E
P
M
G
C
Y
D
--
D
I
E
Q
A
D
A
F
V
L
W
G
A
N
M
A
E
-
M
-
H
P
I
L
W
--
S
-----------
R
I
T
---
N
-------------
R
R
-
L
-
S
N
Q
-----
N
V
T
V
A
V
L
S
T
Y
Q
H
R
S
F
E
L
A
--------
D
N
G
--------
I
I
F
T
P
Q
S
D
L
V
I
L
N
Y
I
A
N
Y
I
I
Q
N
------
N
A
I
N
Q
D
F
F
S
K
H
V
N
L
R
K
G
A
T
DIGYGLRPTH
P
L
E
K
A
AKNPGSDASEPM-------------------------------------
S
---------
F
E
D
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
V
A
E
Y
T
L
E
K
T
A
E
M
T
G
V
P
K
D
Q
L
E
Q
L
A
Q
L
Y
A
D
P
------
N
-
K
------
K
V
I
-
S
Y
W
-
T
M
G
F
-
N
Q
H
T
R
--
G
V
W
A
N
N
L
V
Y
N
L
H
--
L
L
T
G
K
I
S
Q
P
G
C
------------
G
P
F
S
L
T
G
-------------
Q
------------
P
S
A
-
C
G
T
A
R
E
-
V
G
T
F
A
---------
H
--
R
L
----
P
A
-----------------
D
M
V
V
-
T
N
-----
E
K
H
R
-
D
I
C
------------
E
K
K
----
W
N
I
PSG
T
---
I
---
P
----------------------
A
---
K
----------
I
G
L
H
A
-
V
A
Q
D
----------
R
A
L
K
--------------
D
G
K
---
L
N
V
Y
W
T
M
C
T
N
N
M
Q
A
G
P
N
------------------------------
I
N
EE
R
-
M
P
--
G
W
-------------------------------
R
D
----
P
R
----
N
-
F
I
I
V
S
D
P
Y
P
--
T
V
-
S
A
L
A
A
D
L
I
L
P
T
A
M
W
V
E
K
E
G
A
Y
G
N
A
---
E
R
R
---
T
Q
F
W
R
Q
Q
V
Q
A
P
G
E
A
K
S
D
---
L
W
Q
L
V
Q
F
S
R
R
F
K
---------------
T
------
E
---------------
E
V
-----------------------
W
P
E
----------
D
L
-----------------------------------
L
A
K
K
PELRGKTLY
E
---
V
------
L
Y
---
A
T
-------------
P
EVSKFPVSELAEDQLN
D
E
S
R
E
L
GFY
L
------------
Q
--------
K
----
G
L
F
E
E
Y
A
W
F
G
RGHGHDLA-------------------------------------
P
F
D
D
----------------
Y
--------------------
H
-----
K
---------------------------
A
------------------------------
R
G
--
L
R
W
P
V
VNGKETQWR----
Y
S
--
E
G
-
N
D
P
-----
Y
V
----------
K
A
---------------
G
---
E
G
---------------
Y
K
-------------
F
YGK
P
D
G
K
A
V
I
F
A
L
P
F
------------
E
------------
P
------
A
----
A
----
E
-------------
A
P-----------
D
E
E
Y
D
L
W
L
S
T
G
R
V
L
E
H
W
H
T
G
S
M
T
R
R
V
P
E
L
H
R
A
F
-
P
E
A
V
L
F
I
H
P
L
D
A
K
A
R
D
L
R
R
G
D
K
V
K
V
V
S
R
R
G
--
E
--
V
--
I
S
I
V
E
T
R
--
G
R
N
R
P
P
Q
G
L
V
Y
M
P
F
F
D
A
A
------
Q
--------------------
L
V
N
K
L
T
L
D
-
A
T
-
D
P
L
---
S
K
E
T
--------------
D
F
----------------
K
K
C
A
V
K
L
E
K
----------------------------------------------
10
PsiBlast_PDB
88.66
25%
-58
- C- -
1OGY
5
NAPA_RHOS4
A:
[12-801]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
W
S
K
A
P
-
C
R
F
C
G
--
T
G
C
G
V
M
V
G
T
R
D
G
-------------------------------------------
Q
V
V
A
T
H
G
-------
D
T
Q
A
E
V
N
-------
R
G
L
N
C
V
K
G
Y
F
L
S
K
I
M
Y
G
-----
E
-----
D
R
L
T
T
P
L
L
R
MKDGVYH
K
----
E
--------------------------------------
G
E
F
A
P
V
S
W
D
E
A
F
D
V
M
A
A
Q
A
-
K
L
V
L
K
E
K
A
P
E
A
V
G
M
F
----
G
S
----
G
Q
W
T
I
W
E
G
Y
A
A
S
K
L
M
R
A
G
F
R
S
N
N
L
D
P
N
-----
A
-
R
H
C
M
A
S
---
A
A
T
A
F
M
R
T
F
G
M
D
E
P
M
G
C
Y
D
--
D
F
E
A
A
D
A
F
V
L
W
G
S
N
M
A
E
-
M
-
H
P
I
L
W
--
S
-----------
R
L
T
D
--
R
------------
R
L
S
-
H
-
E
H
V
-----
R
V
--
A
V
L
S
T
F
T
H
R
S
S
D
L
S
--------
D
T
P
--------
I
I
F
R
P
G
T
D
R
A
I
L
N
Y
I
A
H
H
I
I
S
T
------
G
R
V
N
R
D
F
V
D
R
H
T
N
F
A
L
G
ATDIGYGLRPEH
Q
L
Q
L
A
AKGAADAG
A
M
T
P
T
------------------------------------
D
---------
F
E
T
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
V
S
E
Y
T
L
E
K
A
A
E
I
S
G
V
E
P
A
L
L
E
E
L
A
E
L
Y
A
D
P
------
D
-
R
------
K
W
M
S
L
-
W
-
T
M
G
F
-
N
Q
H
V
R
--
G
V
W
A
N
H
M
V
Y
N
L
H
--
L
L
T
G
K
I
S
E
P
G
N
------------
S
P
F
S
L
T
G
-------------
Q
------------
P
F
A
-
C
G
T
A
R
E
-
V
G
T
F
A
---------
H
--
R
L
----
P
A
-----------------
D
M
V
V
-
T
N
-----
P
E
H
R
-
A
H
A
------------
E
E
I
----
W
K
L
---
P
AGL
L
---
P
----------------------
D
---
W
----------
V
G
A
H
A
-
V
E
Q
D
----------
R
K
L
H
--------------
D
G
E
---
I
N
F
Y
W
V
Q
V
N
N
N
M
Q
A
A
P
N
------------------------------
I
D
-----
Q
--
E
T
-------------------------------
Y
P
----
G
Y
R
NPE
N
-
F
I
V
V
S
D
A
Y
P
--
T
V
-
T
G
R
A
A
D
L
V
L
P
A
A
M
W
V
E
K
E
G
A
Y
G
N
A
---
E
R
R
---
T
H
F
W
H
Q
L
V
E
A
P
G
E
A
R
S
D
L
W
Q
L
M
E
-
F
S
K
R
F
T
T
D
---------------
E
------
V
---------------
W
-------------------------
P
E
----------
E
I
-----------------------------------
L
S
-----------
A
---
A
PAYRGK
T
L
---
F
E
-------------
V
-------------------------
L
------------
F
--------
A
----
N
G
-----------------------------------------------------
S
V
D
R
FPASDVNPDHAN
H
E
A
A
L
--------------------
F
-----
G
---------------------------
F
Y
P
Q
K
G
L
F
E
E
Y
A
A
F
G
RGHGHDLAP
F
D
T
Y
H
E
V
R
G
--
L
H
W
P
V
-------------
V
---
E
G
-
E
E
T
-----
R
W
----------
R
Y
---------------
R
---
E
G
---------------
F
D
PYVKPGEGLRFYG
K
---
P
D
G
R
A
V
I
L
G
V
P
Y
------------
E
------------
P
------
P
----
A
----
E
-------------
S
P-----------
D
E
E
F
G
F
W
L
V
T
G
R
V
L
E
H
W
H
S
G
S
M
T
L
R
W
P
E
L
Y
K
A
F
-
P
G
A
V
C
F
M
H
P
E
D
A
R
S
R
G
L
N
R
G
S
E
V
R
V
I
S
R
R
G
--
E
I
R
T
--
R
L
E
T
R
G
R
--
N
R
M
P
R
G
V
--
V
F
V
P
W
F
D
A
S
------
Q
L
-----------------
I
N
K
V
T
L
D
A
N
D
-
P
I
-
S
R
Q
---
T
D
-----------------
F
----------------
K
K
C
A
V
K
I
E
A
----------------------------------------------
52
HHSearch
88.28
26%
-39
- C1 -
3ML1
5
NAPA_CUPNH
A:
[6-802]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
E
V
T
K
L
K
W
S
K
A
P
-
C
R
F
C
G
--
T
G
C
G
V
T
V
A
V
K
D
N
-------------------------------------------
K
V
V
A
T
Q
G
-------
D
P
Q
A
E
V
N
-------
K
G
L
N
C
V
K
G
Y
F
L
S
K
I
M
Y
G
-----
Q
-----
D
R
L
T
R
P
L
M
R
-------
M
----
K
NGKYDKN-------------------------------
G
D
F
A
P
V
T
W
D
Q
A
F
D
E
M
E
R
Q
F
-
K
R
V
L
K
E
K
G
P
T
A
V
G
M
F
----
G
S
----
G
Q
W
T
V
W
E
G
Y
A
A
A
K
L
Y
K
A
G
F
R
S
N
N
I
D
P
N
-----
A
-
R
H
C
M
A
S
---
A
A
A
G
F
M
R
T
F
G
M
D
E
P
M
G
C
Y
D
--
D
F
E
A
A
D
A
F
V
L
W
G
S
N
M
A
E
-
M
-
H
P
I
L
W
--
T
-----------
R
V
T
---
D
------------
R
R
L
-
S
H
P
K
T
-----
R
V
--
V
V
L
S
T
F
T
H
R
C
F
D
L
A
--------
D
I
G
--------
I
I
F
K
P
Q
T
D
L
A
M
L
N
Y
I
A
N
Y
I
I
R
N
------
N
K
V
N
K
D
F
V
N
K
H
T
V
F
K
E
G
V
T
DIGYGLRPDH
P
L
Q
K
A
AKNASDPG
A
A
K
V
I
------------------------------------
T
---------
F
D
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
F
V
S
K
Y
D
A
D
Y
V
S
K
L
S
A
V
P
K
A
K
L
D
Q
L
A
E
L
Y
A
D
P
------
N
I
K
------
V
M
S
-
L
-
W
-
T
M
G
F
-
N
Q
H
T
R
--
G
T
W
A
N
N
M
V
Y
N
L
H
--
L
L
T
G
K
I
A
T
P
G
N
------------
S
P
F
S
L
T
G
-------------
Q
------------
P
S
A
-
C
G
T
A
R
E
-
V
G
T
F
S
---------
H
--
R
L
----
P
A
-----------------
D
M
V
V
-
T
N
-----
P
K
H
R
-
E
E
A
------------
E
R
I
----
W
K
L
---
P
---
P
GTI
P
----------------------
D
---
K
----------
P
G
Y
D
A
-
V
L
Q
N
----------
R
M
L
K
--------------
D
G
K
---
L
N
A
Y
W
V
Q
V
N
N
N
M
Q
A
A
A
N
----------------------------------
L
-
M
E
--
E
G
-------------------------------
L
P
G
Y
R
N
P
A
----
N
-
F
I
V
V
S
D
A
Y
P
--
T
V
-
T
A
L
A
A
D
L
V
L
P
S
A
M
W
V
E
K
E
G
A
Y
G
N
A
---
E
R
R
---
T
Q
F
W
H
Q
L
V
D
A
P
G
E
A
R
S
D
-
L
W
Q
L
V
E
F
A
K
R
F
K
V
E
---------------
E
------
V
---------------
W
P
-----------------------
P
E
L
I
A
K
K
PEYKGK
T
L
-----------------------------------
Y
D
-----------
V
---
L
------
Y
R
NGQ
V
D
KFPL---------
K
-------------------------
D
VNAEYHN
A
E
A
K
A
F
--------
G
FY
L
Q
K
G
-----------------------------------------------------
L
F
E
E
----------------
Y
A
T
F
G
RGHGHDLAP
F
D
A
Y
H
E
A
R
-----
G
---------------------------
L
------------------------------
R
W
--
P
V
V
N
----------------------
G
K
-----
E
T
----------
R
W
RYREGSDPYVKAGTG
F
---
Q
F
---------------
Y
G
-------------
N
---
P
D
G
K
A
V
I
F
A
L
P
Y
------------
E
------------
P
------
P
----
A
----
E
S------------
P
------------
D
K
E
Y
P
Y
W
L
V
T
G
R
V
L
E
H
W
H
S
G
S
M
T
R
R
V
P
E
L
Y
R
S
F
-
P
N
A
V
V
F
M
H
P
E
D
A
K
A
L
G
L
R
R
G
V
E
V
E
V
V
S
R
R
G
--
R
--
M
--
R
S
R
I
E
T
R
GR
D
A
P
P
R
G
L
--
V
F
V
P
W
F
D
A
--------------------------
S
Q
L
I
N
K
V
T
L
D
-
A
T
-
C
P
I
---
S
L
Q
T
--------------
D
F
----------------
K
K
C
A
V
K
I
V
K
V
---------------------------------------------
55
HHSearch
83.93
22%
-41
- C1 -
1G8K
5
AIOA_ALCFA
A:
[9-817]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
A
N
A
Q
R
T
N
M
T
-
C
H
F
C
I
--
V
G
C
G
Y
H
V
Y
K
W
P
E
L
E
E
G
G
RAPEQNALGLDFRKQLPPLA
V
T
L
T
PAM
T
N
V
V
T
E
HDG
A
R
Y
D
I
M
V
V
P
-------
D
K
A
C
V
V
N
-------
S
G
L
S
S
T
R
G
G
K
M
A
S
Y
M
Y
T
-----
P
TGDGK
E
R
L
S
A
P
R
L
Y
-------
A
----
A
--------------------------------------
D
E
W
V
D
T
T
W
D
H
A
M
A
L
Y
A
G
L
I
-
K
K
T
L
D
K
D
G
P
Q
G
V
F
F
S
----
C
F
DHGG
A
G
G
G
F
E
N
T
W
G
T
G
K
L
M
F
S
A
I
Q
T
P
M
V
R
I
H
NRPAY
N
-
S
E
C
H
A
T
---
R
------
E
M
G
I
G
E
L
N
N
A
Y
E
--
D
A
Q
L
A
D
V
I
W
S
I
G
N
N
P
Y
E
-
S
-
Q
T
N
Y
F
L
N
H
-----------
W
L
P
N
L
Q
G
AT
T
S
K
K
K
E
R
F
PN
E
-
N
-
F
-
P
Q
A
-----
R
I
--
I
F
V
D
P
R
E
T
P
S
V
A
I
A
R
H
V
AGNDR
V
L
H
--------
L
A
I
E
P
G
T
D
T
A
L
F
N
G
L
F
T
Y
V
V
E
Q
------
G
W
I
D
K
P
F
I
E
A
H
T
K
----------------------------------------------------------------------
G
---------
F
D
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
T
-
N
R
L
S
L
D
E
C
S
N
I
T
G
V
P
V
D
M
L
K
R
A
A
E
W
S
Y
K
P
KASGQA
P
-
R
------
T
M
H
-
A
-
Y
-
E
K
G
I
-
I
W
G
N
D
--
N
Y
V
I
Q
S
A
L
L
D
L
V
--
I
A
T
H
N
V
G
R
R
G
T
------------
G
C
V
R
M
G
G
-------------
H
------------
Q
E
G
---
Y
-------
T
R
---------
P
--
P
Y
----
P
G
-----------------
D
K
K
----------------------------------------------------------------------------------------------
I
Y
I
D
----------
Q
E
L
I
--------------
K
G
K
---
G
R
I
M
T
W
W
G
C
N
N
F
Q
T
S
N
N
A
Q
A
L
R
E
A
I
L
Q
R
S
A
I
V
K
Q
A
M
Q
K
ARGAT
T
E
E
M
V
D
--
V
-
I
Y
--
E
A
-------------------------------
T
Q
----
N
G
G
---
L
-
F
V
T
S
I
N
L
Y
P
--
T
K
-
L
A
E
A
A
H
L
M
L
P
A
A
H
P
G
E
M
N
L
T
S
M
N
G
---
E
R
R
---
I
R
L
S
E
K
F
M
D
P
P
G
T
A
M
A
D
-
C
L
I
A
A
R
I
A
N
A
L
R
D
M
Y
Q
K
D
GK
A
E
M
A
A
Q
F
EG
F
------
D
---------------
W
K
-----------------------
T
E
E
----------
D
A
-----------------------------------
F
N
-----------
D
---
G
------
F
R
---
R
A
GQPGA--------
P
-------------------------
A
------------
I
D
S
QGGSTG
H
----
L
V
-----------------------------------------------------
T
Y
D
R
----------------
L
--------------------
R
K
S
GNN
G
---------------------------
V
------------------------------
Q
L
--
P
V
V
S
W
-------------
D
E
SK
G
L
-
V
G
T
-----
E
M
----------
L
Y
---------------
T
E--
G
K
---------------
F
D
-------------
T
---
D
D
G
K
A
H
F
K
P
A
P
W
------------
N
------------
G
------
L
----
P
A
T
V
Q
Q
-------------
Q
------------
K
D
K
Y
R
F
W
L
N
N
G
R
N
N
E
V
W
Q
T
A
Y
H
D
Q
Y
N
S
L
M
Q
E
R
Y
-
P
M
A
Y
I
E
M
N
P
D
D
C
K
Q
L
D
V
T
G
G
D
I
V
E
V
Y
N
D
F
G
--
S
--
T
--
F
A
M
V
Y
P
V
--
A
E
I
K
R
G
Q
--
T
F
M
L
F
G
Y
V
--------------------------
N
G
I
Q
G
D
V
T
T
--
D
W
-
T
D
R
---
D
I
I
P
--------------
Y
Y
----------------
K
G
T
W
G
D
I
R
K
V
G
S
M
S
E
-
F
K
R
T
V
----------------------------------
59
HHSearch
81.64
18%
-34
- C1 -
2IVF
11
?
A:
[80-976]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
H
-
L
N
I
C
W
PQ
G
S
C
K
F
Y
V
Y
V
R
N
G
-------------------------------------------
I
V
W
R
E
E
Q
-------
A
A
Q
T
P
A
C
NVDYVDY
N
P
L
G
C
Q
K
G
S
A
F
N
N
N
L
Y
G
-----
D
-----
E
R
V
K
Y
P
L
K
R
-------
V
GKRG
E
--------------------------------------
G
K
W
K
R
V
S
W
D
E
A
A
G
D
I
A
D
S
I
-
I
D
S
F
E
A
Q
G
S
D
G
F
I
L
D
----
A
P
HVHA
G
S
I
A
W
G
A
G
F
R
M
T
Y
L
M
D
G
V
S
P
D
I
N
------------
V
D
I
G
D
---
T
Y
M
G
A
F
H
T
F
G
K
M
H
M
G
Y
S
A
D
--
N
L
L
D
A
E
L
I
F
M
T
C
S
N
W
S
Y
-
T
-
Y
P
S
S
Y
--
H
-----------
F
L
S
---
E
------------
A
-
R
-
Y
-
K
G
A
-----
E
V
--
V
V
I
A
P
D
F
N
P
T
T
P
A
A
--------
D
L
H
--------
V
P
V
R
V
G
S
D
A
A
F
W
L
G
L
S
Q
V
M
I
D
E
------
K
L
F
D
R
Q
F
V
C
E
Q
T
D
LP
L
L
V
R
MDTGKFLSAEDVDGGEAK
Q
F
Y
F
F
D
EKAG
S
V
R
K
A
S
RGTLKLDFMPAL
E
G
T
F
S
A
R
L
KNG
K
T
I
Q
V
R
T
V
---------
F
E
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
H
L
K
D
Y
T
P
E
K
A
S
A
K
C
G
V
P
V
S
L
I
R
E
L
G
R
K
V
A
K
K
--------
R
------
T
C
S
-
Y
-
I
-
G
F
S
S
-
A
K
S
Y
H
--
G
D
L
M
E
R
S
L
F
L
A
M
--
A
L
S
G
N
W
G
K
P
G
T
------------
G
A
F
A
W
A
Y
-------------
S
D
D
N
M
V
Y
L
G
VMSK
P
T
A
-
Q
G
G
M
-
D
E
L
H
Q
M
A
---------
E
--
G
F
----
N
K
R
T
L
E
-------------
A
D
P
T
S
T
D
-----
E
M
G
N
-
I
E
F
------------
M
K
V
V
T
S
A
V
G
L
---
V
---
P
---
P
A
M
W
L
Y
Y
HVGY
D
Q
L
W
N
NKAWTDP
A
LKK
S
----------
F
G
A
Y
L
-
D
E
A
K
E
K
GWWTNDHI
R
P
A
P
--------------
D
K
T
---
P
Q
V
Y
M
L
L
S
Q
N
P
M
R
R
K
R
S
------------------------------
G
A
--
K
-
M
F
P
D
V
L
-------------------------------
F
P
----
K
L
----
K
-
M
I
F
A
L
E
T
R
M
--
S
S
-
S
A
M
Y
A
D
I
V
L
P
C
A
W
Y
Y
E
K
H
E
M
T
T
P
C
SG-
N
P
F
---
F
T
F
V
D
R
S
V
A
P
P
G
E
C
R
E
E
-
W
D
A
I
A
L
I
L
K
K
V
G
E
R
---------------
A
A
A
R
GL
T
E
---------------
F
N
D
HNG
R
K
R
R
YDE
L
Y
K
K
F
T
M
DGHLL
T
N
E
----------
D
C
-----------------------------------
L
K
-----------
E
---
M
------
V
D
---
I
N
-------------
R
-------------------------
A
V
GVF--------
A
--------
K
----
D
Y
-----------------------------------------------------
T
Y
E
K
----------------
F
--------------------
K
K
E
---
G
---------------------------
Q
T-----------------------------
R
F
--
L
S
M
G
T
GVSRYAHA
N
E
V
D
V
T
K
--
P
I
Y
P
M
R
-----
W
H
----------
F
D
D--------------
K
---
K
V
---------------
F
P
-------------
T
---
H
T
R
R
A
Q
F
Y
L
D
H
D
------------
W
Y
L
E
A
GES
L
P
T
H
K
D
------
T
----
P
----
M
-------------
V
------------
G
G
D
H
P
F
K
I
T
G
G
H
P
R
V
S
I
H
S
T
H
--
L
T
N
S
H
L
S
R
L
H
R
G
Q
P
V
V
H
M
N
S
K
D
A
A
E
L
G
I
K
D
G
D
M
A
K
L
F
N
D
F
A
--
D
--
C
--
E
I
M
V
R
T
A
--
P
N
V
Q
P
K
Q
--
C
I
V
Y
F
W
D
A
H
------
Q
Y
-------
K
--------
G
W
K
P
Y
D
I
L
L
I
G
-
M
P
-
K
P
L
HLA
G
G
Y
E
QFRYYFMNGSPAPV
T
D
----------------
R
G
V
R
V
S
I
K
K
A
---------------------------------------------
75
Fugue
81.00
21%
-31
- C1 -
1G8K
6
AIOA_ALCFA
A:
[4-825]
----------------------------------------------------------------------------
N
D
R
I
T
L
P
P
A
N
A
-----------------------------------------------------
Q
R
T
N
M
T
C
H
F
C
I
---------------------------------------
V
G
C
G
Y
H
V
Y
K
W
P
------------
E
L
E
E
G
G
R
A
P
E
Q
N
A
L
G
L
D
F
R
K
Q
L
P
P
L
A
V
T
L
T
P
A
M
T
N
V
V
T
E
H
D
G
A
--------------------------
R
-------------------------------------------
Y
D
I
M
V
V
P
-------
D
K
A
C
V
V
N
-------
S
G
L
S
S
T
R
G
G
K
M
A
S
Y
M
Y
T
PTGDG
K
-----
E
R
L
S
A
P
R
L
Y
-------
A
----
A
--------------------------------------
D
E
W
V
D
T
T
W
D
H
A
M
A
L
Y
A
G
L
I
-
K
K
T
L
D
K
D
G
P
Q
G
V
F
F
S
C
F
DH
G
G
----
A
G
G
G
F
E
N
T
W
G
T
G
K
L
M
F
S
A
I
Q
T
P
M
V
R
I
H
-----
N
-
R
P
A
Y
N
S
---
E
C
-
H
A
T
R
E
M
G
I
G
E
L
N
N
A
Y
E
--
D
A
Q
L
A
D
V
I
W
S
I
G
N
N
P
Y
E
-
S
-
Q
T
N
Y
F
--
L
NH
W
L
P
N
L
Q
GAT
T
S
K
---
K
------------
K
E
R
-
F
-
P
N
E
N
F
P
Q
A
R
I
--
I
F
V
D
P
R
E
T
P
S
V
A
I
A
--------
R
H
V
AGNDRVLH
L
A
I
E
P
G
T
D
T
A
L
F
N
G
L
F
T
Y
V
V
E
Q
------
G
W
I
D
K
P
F
I
E
A
H
T
K
----------------------------------------------------------------------
G
---------
F
D
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
T
-
N
R
L
S
L
D
E
C
S
N
I
T
G
V
P
V
D
M
L
K
R
A
A
E
W
S
Y
K
P
------
K
-
A
SGQAPR
T
M
H
-
A
-
Y
-
E
K
G
I
-
I
W
G
N
D
--
N
Y
V
I
Q
S
A
L
L
D
L
V
--
I
A
T
H
N
V
G
R
R
G
T
------------
G
C
V
R
M
G
G
-------------
H
------------
Q
E
G
-
Y
T
R
P
-
P
-
Y
---
P
---------
G
--
D
K
----
K
I
-----------------
Y
I
D
Q
-
E
L
-----
I
K
G
K
-
G
R
I
------------
M
T
W
----
W
G
C
---
N
---
N
---
F
----------------------
Q
---
T
----------
S
N
N
A
Q
-
A
L
R
E
----------
A
I
L
Q
--------------
R
S
A
---
I
V
K
Q
A
M
Q
K
A
R
G
A
T
T
E
E
M
------------------------------
V
D
--
V
-
I
Y
--
E
A
-------------------------------
T
Q
----
N
G
----
G
L
F
V
T
S
I
N
L
Y
P
--
T
K
-
L
A
E
A
A
H
L
M
L
P
A
A
H
P
G
E
M
N
L
T
S
M
N
G
---
E
R
R
---
I
R
L
S
E
K
F
M
D
P
P
G
T
A
M
A
D
-
C
L
I
A
A
R
I
A
N
A
L
R
D
M
---------------
Y
------
Q
K
D
GK
A
E
M
A
A
Q
F
EGFD
W
K
-----------------------
T
E
E
----------
D
A
-----------------------------------
F
N
-----------
D
---
G
------
F
R
---
R
A
GQPGA
P
A
I
D
S
QGG
S
-------------------------
T
------------
G
--------
H
----
L
V
-----------------------------------------------------
T
Y
D
R
----------------
L
--------------------
R
-----
K
---------------------------
S
------------------------------
G
N
NG
V
Q
L
P
V
-------------
V
S
--
W
D
-
E
S
K
G
L
V
G
T
E
M
----------
L
Y
---------------
T
---
E
G
K--------------
F
D
-------------
T
---
D
D
G
K
A
H
F
K
P
A
P
W
NGLP--------
A
------------
T
------
V
----
Q
----
Q
-------------
Q
------------
K
D
K
Y
R
F
W
L
N
N
G
R
N
N
E
V
W
Q
T
A
Y
H
D
Q
Y
N
S
L
M
Q
E
R
Y
-
P
M
A
Y
I
E
M
N
P
D
D
C
K
Q
L
D
V
T
G
G
D
I
V
E
V
Y
N
D
F
G
--
S
--
T
--
F
A
M
V
Y
P
V
--
A
E
I
K
R
G
Q
--
T
F
M
L
F
G
Y
V
N
--------------------------
G
I
Q
G
D
V
T
T
D
-
W
T
-
D
R
----
D
I
I
P
--------------
Y
Y
----------------
K
G
T
W
G
D
I
R
K
V
-----------------
G
S
M
S
E
F
K
R
T
V
S
F
K
S
R
R
F
G
----------
72
Fugue
78.89
24%
-27
- C1 -
2VPZ
4
?
A:
[30-763]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
W
Y
A
Q
E
V
K
S
V
Y
Q
I
-
C
E
G
C
F
--
W
R
C
G
I
V
A
H
A
V
G
N
-------------------------------------------
R
V
Y
K
V
E
G
-------
Y
E
A
N
P
K
S
-------
R
G
R
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
-----
P
-----
D
R
L
K
R
P
L
I
R
VEGSQR-
G
----
E
--------------------------------------
G
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
-
L
E
I
R
E
K
Y
G
P
E
A
I
A
F
F
----
G
H
----
G
T
---
G
D
Y
W
F
V
D
F
L
P
A
A
W
G
S
P
N
A
A
K
P
S
-----
V
-
S
L
C
T
A
P
---
R
E
V
A
S
Q
W
V
F
G
R
P
I
G
G
H
E
P
I
--
D
W
E
N
A
R
Y
I
V
L
I
G
H
H
I
G
E
D
T
-
H
N
T
Q
L
--
Q
-----------
D
F
A
---
L
------------
A
L
K
-
N
--
G
A
-----
K
V
--
V
V
V
D
P
R
F
S
T
A
A
A
K
A
--------
H
R
W
--------
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
------
D
L
Y
D
K
E
Y
V
A
K
Y
T
V
----------------------------------------------------------------------
G
---------
F
E
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
H
V
K
D
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
R
E
M
A
A
H
------
K
-
P
------
R
A
V
-
L
-
P
P
T
R
H
N
-
V
W
Y
G
D
--
D
T
Y
R
V
M
A
L
L
Y
V
N
--
V
L
L
G
N
Y
G
R
P
G
G
FY
I
A
Q
S
P
Y
L
E
K
Y
P
L
P
P
L
P
L
-------------
E
------------
P
A
A
-
G
G
C
S
-
G
-
P
S
G
G
D
---------
H
--
E
P
----
E
G
-----------------
F
K
P
R
--------
A
D
K
G
-
K
F
F
------------
A
R
S
----
T
A
I
---
Q
---
E
---
L
----------------------
I
---------------------
E
P
M
----------
I
T
G
E
--------------
P
Y
P
---
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
------------------------------
V
P
--
R
-
T
K
--
E
A
-------------------------------
L
K
----
N
L
----
D
-
L
Y
V
A
I
D
V
L
P
--
Q
E
-
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
Y
D
D
F
V
L
V
---
A
H
K
T
P
F
I
Q
L
R
T
P
A
H
E
P
L
F
D
T
K
P
G
-
W
W
I
A
R
E
L
G
L
R
L
G
L
E
---------------
Q
------
Y
---------------
F
-------------------------
P
W
----------
K
T
-----------------------------------
I
E
-----------
E
---
Y
------
L
E
---
T
R
-------------
L
-------------------------
Q
------------
S
--------
L
----
G
L
-----------------------------------------------------
D
L
E
T
----------------
M
--------------------
K
-----
G
---------------------------
M
------------------------------
G
T
--
L
V
Q
R
G
-------------
K
P
--
W
L
-
E
D
W
-----
E
K
E
G
R
L
P
F
GTAS
G
K
---------------
I
---
E
L
---------------
Y
C
-------------
Q
---
R
F
K
E
A
G
H
Q
P
L
P
V
------------
F
------------
T
------
P
----
P
----
E
-------------
E
------------
P
P
E
G
F
Y
R
L
L
Y
G
R
S
--
P
V
H
T
F
A
R
T
Q
N
N
W
V
L
M
E
M
D
-
P
E
N
E
V
W
I
H
K
E
E
A
K
R
L
G
L
K
E
G
D
Y
V
M
L
V
N
Q
D
G
V
K
E
--
G
--
P
V
R
V
K
P
T
--
A
R
I
R
K
D
C
--
V
Y
I
V
H
G
F
G
H
KAPLMR
L
A
H
------
G
--------
R
G
A
S
D
N
Y
L
Q
T
R
-
Y
K
L
D
P
I
---
S
G
G
A
--------------
G
L
----------------
R
V
N
F
V
R
L
E
K
A
E
R
P
R
L
P
S
L
T
G
L
A
K
R
P
F
D
E
R
--------------------------
53
HHSearch
78.56
24%
-31
- C1 -
2VPZ
4
?
A:
[32-754]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Y
A
Q
E
V
K
S
V
Y
Q
I
-
C
E
G
C
F
--
W
R
C
G
I
V
A
H
A
V
G
N
-------------------------------------------
R
V
Y
K
V
E
G
-------
Y
E
A
N
P
K
S
-------
R
G
R
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
-----
P
-----
D
R
L
K
R
P
L
I
R
-------
V
----
E
GSQRGE--------------------------------
G
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
-
L
E
I
R
E
K
Y
G
P
E
A
I
A
F
F
----
G
H
----
G
T
---
G
-
D
Y
W
F
V
D
F
L
P
A
A
W
G
S
P
N
A
A
K
P
S----
V
-
S
L
C
T
A
P
---
R
E
V
A
S
Q
W
V
F
G
R
P
I
G
G
H
E
P
I
--
D
W
E
N
A
R
Y
I
V
L
I
G
H
H
I
G
E
-
D
T
H
N
T
Q
L
--
Q
-----------
D
F
A
---
L
------------
A
-
L
-
K
-
N
G
A
-----
K
V
--
V
V
V
D
P
R
F
S
T
A
A
A
K
A
--------
H
R
W
--------
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
------
D
L
Y
D
K
E
Y
V
A
K
Y
T
V
----------------------------------------------------------------------
G
---------
F
E
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
H
V
K
D
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
R
E
M
A
A
H
------
K
-
P
------
R
A
V
-
L
-
P
-
P
T
R
H
N
V
W
Y
G
D
--
D
T
Y
R
V
M
A
L
L
Y
V
N
--
V
L
L
G
N
Y
G
R
P
G
G
------------
F
Y
I
A
Q
S
P
-------------
Y
------------
L
E
K
-
Y
P
L
P
-
P
-
L
P
L
E
P
A
AGGCSGPS
G
GD
H
E
P---
E
G
-----------------
F
K
P
----------
R
A
---
D
K
------------
G
K
F
----
F
----------------------------------------
A
----------
R
S
T
A
I
-
Q
E
L
I
----------
E
P
M
I
TGE-----------
P
Y
P
---
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
------------------------------
V
P
--
R
-
T
K
--
E
A
-------------------------------
L
K
----
N
L
----
D
-
L
Y
V
A
I
D
V
L
P
--
Q
E
-
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
Y
D
D
F
V
L
V
A
HK
T
P
F
---
I
Q
L
R
T
P
A
H
E
P
L
F
D
T
K
P
G
-
W
W
I
A
R
E
L
G
L
R
L
G
L
E
---------------
Q
YF----
P
---------------
W
K
-----------------------
T
I
E
----------
E
Y
-----------------------------------
L
E
-----------
T
---
R
------
L
Q
---
S
--------------------------------------------------------------
L
----
G
L
-----------------------------------------------------
D
L
E
T
----------------
M
--------------------
K
-----
G
---------------------------
M
------------------------------
G
T
--
L
V
Q
R
G
--------------
K
--
P
W
-
L
E
D
-----
W
E
----------
K
E
G--------------
R
---
L
P
---------------
F
G
-------------
T
---
A
S
G
K
I
E
L
Y
C
Q
R
F
------------
K
------------
E
AGHQPL
P
VFTP
P
----
E
-------------
E
------------
P
P
E
G
F
Y
R
L
L
Y
G
R
S
P
V
H
T
F
A
R
T
--
Q
N
N
W
V
L
M
E
M
D
-
P
E
N
E
V
W
I
H
K
E
E
A
K
R
L
G
L
K
E
G
D
Y
V
M
L
V
N
Q
D
G
--
V
--
K
E
G
P
V
R
V
K
P
T
--
A
R
I
R
K
D
C
--
V
Y
I
V
H
G
F
G
H
------
K
A
P
LMRLAH
G
--------
R
G
A
S
D
N
Y
L
Q
T
R
Y
K
L
-
D
P
I
---
S
G
G
A
--------------
G
L
----------------
R
V
N
F
V
R
L
E
K
A
E
R
P
R
L
P
S
L
T
G
-----------------------------------
56
HHSearch
78.13
20%
-38
- C1 -
1Q16
4
NARG_ECOLI
A:
[38-1237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
W
Q
H
D
K
I
V
R
S
T
H
G
V
N
C
T
--
G
S
C
S
W
K
I
Y
V
K
N
G
-------------------------------------------
L
V
T
W
E
T
Q
Q
TDYPRT
R
P
D
L
P
N
H
-------
E
P
R
G
C
P
R
G
A
S
Y
S
W
Y
L
Y
S
-----
A
-----
N
R
L
K
Y
P
M
M
R
-------
K
----
R
L
M
K
M
W
R
E
A
K
A
L
H
SD
P
V
E
A
W
A
S
I
I
E
D
A
D
K
A
K
S
F
K
Q
A
RGR
G
G
F
V
R
S
S
W
Q
E
V
N
E
L
I
A
A
S
N
-
V
Y
T
I
K
N
Y
G
P
D
R
V
A
G
F
----
S
P
----
I
P
A
M
S
M
V
S
Y
A
S
G
A
R
Y
L
S
L
I
G
G
T
C
L
S
F
Y
-----
D
-
W
Y
C
D
L
P
---
P
--
A
S
P
Q
T
W
G
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Q
T
D
V
P
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S
A
--
D
W
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N
S
S
Y
I
I
A
W
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S
N
V
P
Q
-
T
-
R
T
P
D
A
--
H
-----------
F
F
T
---
E
------------
V
-
R
-
Y
-
K
G
T
-----
K
T
--
V
A
V
T
P
D
Y
A
E
I
A
K
L
C
--------
D
L
W
--------
L
A
P
K
Q
G
T
D
A
A
M
A
L
A
M
G
H
V
M
L
R
E
FHLDNP
S
Q
Y
F
T
D
Y
V
R
R
Y
T
D
----------------------------------------------------------------------
M
---------
P
M
L
V
M
L
E
E
R
DGYYAAGRMLRAADLVDALGQENNPEW
K
T
V
A
F
N
TNG
E
M
V
A
P
N
GS
I
G
F
R
W
GEKGKWNLEQRDGKTG
E
E
T
E
L
Q
L
S
LLGSQD
E
I
A
E
V
G
F
P
Y
FGGDGTEH
F
N
K
V
E
L
E
N
V
L
L
H
K
L
P
V
K
R
L
Q
L
ADG
S
T
A
L
V
T
T
V
Y
D
L
T
L
A
N
Y
GLERGLNDVNCATS
Y
D
D
V
K
A
Y
T
P
A
W
A
E
Q
I
T
G
V
S
R
S
Q
I
I
R
I
A
R
E
F
A
D
N
A
D
K
T
H-
G
-
R
------
S
M
I
-
I
-
V
-
G
A
G
L
-
N
H
W
Y
H
--
L
D
M
N
Y
R
G
L
I
N
M
L
--
I
F
C
G
C
V
G
Q
S
G
G
------------
G
W
A
H
Y
V
G
-------------
Q
------------
E
K
L
-
R
P
Q
T
-
G
-
W
Q
P
L
A
---------
F
--
A
L
DWQR
P
A
R
H
M
N
S
T
S
Y
F
Y
N
HSSQWR
Y
E
T
V
-
T
A
EELLS
P
M
A
D
K
S
R
Y
T
G
H
L
I
D
F
N
V
R
A
E
R
M
G
----
W
L
P
---
S
---
A
---
P
----------------------
Q
LGT
N
PLT
I
A
G
E
A
E
K
A
G
M
N
P
V
D
Y
T
V
----------
K
S
L
K
E
GSIRFAAEQPENG
K
N
H
---
P
R
N
L
F
I
W
R
S
N
L
L
G
S
S
G
K
------------------------------
G
H
--
E
F
M
L
--
K
Y
LLGTEHGIQGKDLGQQGGVKPEE
V
D
W
Q
DNGL
E
G
----
K
L
----
D
-
L
V
V
T
L
D
F
R
L
--
S
S
-
T
C
L
Y
S
D
I
I
L
P
T
A
T
W
Y
E
K
D
D
M
N
T
S
D
M--
H
P
F
---
I
H
P
L
S
A
A
V
D
P
A
W
E
A
K
S
D
-
W
E
I
Y
K
A
I
A
K
K
F
S
E
V
---------------
C
VGHL--
G
K
E
T
D
I
V
T
L
P
IQ----
H
D
-----------------------
S
A
A
----------
E
L
AQPL
D
V
K
D
WKKGECDLIPGKTA
P
H
I
M
V
V
E
R
DYPA
T
Y
E
-----------
R
---
F
------
T
S
---
I
G
-------------
P
-------------------------
L
------------
M
E
K
I
GNGG-
K
----
G
I
A
W
N
T
Q
S
E
M
D
L
L
R
K
L
NYTKAEGPAKGQPMLNT
A
I
D
A
A
E
M
I
L
T
L
APETN
G
Q
V
A
V
K
A
W
A
A
----------------
L
--------------------
S
E
F
T
--
G
RDHTHLALNKED
E
K
I
R
F
R
D
I
Q
A
Q
P
R
K
I
I
------------------------------
S
S
--
P
T
W
S
G
-------------
L
------
E
D
E
-----
H
V
----------
S
Y
N
A
G
Y
T
N
V
H
E------
L
---
I
P
---------------
W
R
-------------
T
---
L
S
G
R
Q
Q
L
Y
Q
D
H
Q
W
M
R
D
F
GES
L
L
V
Y
R
------------
P
------
P
----
I
----
D
TRSVKEVIGQKSN
G
------------
N
Q
E
K
A
L
N
F
L
T
P
H
Q
K
W
G
I
H
S
T
Y
S
-
D
N
L
L
M
L
T
L
G
R
-
G
G
P
V
V
W
L
S
E
A
D
A
K
D
L
G
I
A
D
N
D
W
I
E
V
F
N
S
N
G
--
A
--
L
--
T
A
R
A
V
V
S
--
Q
R
V
P
A
G
M
--
T
M
M
Y
H
A
Q
E
R
------
I
V
N
------
L
PGSEITQQ
R
G
G
I
H
N
S
V
T
R
I
-
T
P
-
K
P
T
---
H
M
I
G
--------------
G
Y
AHLAYGFNYYGTVGSN
R
D
E
F
V
V
V
R
K
M
-
K
N
I
D
W
L
D
G
E
-----------------------------------
16
PsiBlast_PDB
78.02
24%
-42
- C1 -
2VPZ
4
?
A:
[30-695]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
W
Y
A
Q
E
V
K
S
V
Y
Q
I
-
C
E
G
C
F
--
W
R
C
G
I
V
A
H
A
V
G
N
-------------------------------------------
R
V
Y
K
V
E
G
-------
Y
E
A
N
P
K
S
-------
R
G
R
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
-----
P
-----
D
R
L
K
R
P
L
I
R
VEGSQR-
G
----
E
--------------------------------------
G
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
-
L
E
I
R
E
K
Y
G
P
E
A
I
A
F
F
----
G
H
----
G
T
G
----
D
Y
W
F
V
D
F
L
P
A
A
W
G
S
P
N
A
A
K
P
-----
S
V
S
L
C
T
A
P
R
E
V
A
S
Q
W
V
F
-----
G
R
P
I
G
G
H
E
PI
D
W
E
N
A
R
Y
I
V
L
I
G
H
H
I
G
E
D
T
-
H
N
T
Q
L
--
Q
-----------
D
F
A
---
L
------------
A
L
K
---
N
G
A
-----
K
V
--
V
V
V
D
P
R
F
S
T
A
A
A
K
A
--------
H
R
W
--------
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
------
D
L
Y
D
K
E
Y
V
A
K
Y
T
V
----------------------------------------------------------------------
G
---------
F
E
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
H
V
K
D
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
R
E
M
A
A
H
------
K
-
P
------
R
A
V
------
L
P
P
-
T
R
H
N
V
WY
G
D
D
T
Y
R
V
M
A
L
L
Y
V
N
V
L
L
G
N
Y
G
R
P
G
-------------
G
F
Y
I
A
Q
S
P
Y
L
E
K
YPLPPLP
L
E
------------
P
A
A
-
G
G
C
S
-
G
-
P
S
G
G
D
---------
H
--
E
P
----
E
G
-----------------
F
K
P
--
R
A
-----
D
K
G
K
-
F
-
F
------------
A
R
S
----
T
A
I
---
Q
----------------------------------------------------
E
L
I
----------
E
P
M
I
--------------
T
G
E
PYP
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
------------------------------
V
P
--
R
-
T
K
--
E
A
-------------------------------
L
K
----
N
L
----
D
-
L
Y
V
A
I
D
V
L
P
--
Q
E
-
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
Y
D
D
F
V
L
V
---
A
H
K
T
P
F
I
Q
L
R
T
P
A
H
E
P
L
F
D
T
K
P
G
-
W
W
I
A
R
E
L
G
L
R
L
G
L
E
---------------
Q
------
Y
---------------
F
-------------------------
P
W
----------
K
T
-----------------------------------
I
E
-----------
E
---
Y
------
L
E
---
T
R
-------------
L
-------------------------
Q
------------
S
--------
L
----
G
L
-----------------------------------------------------
D
L
E
T
----------------
M
--------------------
K
-----
G
---------------------------
M
------------------------------
G
T
--
L
V
Q
R
G
-------------
K
P
--
W
L
-
E
D
W
-----
E
K
----------
E
G
---------------
R
---
L
P
---------------
F
G
-------------
T
---
A
S
G
K
I
E
L
Y
C
Q
R
F
------------
K
------------
E
------
A
----
G
----
H
-------------
Q
PLPVFTP
P
E
E
P
P
E
G
F
Y
R
L
L
Y
G
R
S
P
V
----
H
T
F
A
R
T
Q
N
N
W
V
L
M
E
M
D
-
P
E
N
E
V
W
I
H
K
E
E
A
K
R
L
G
L
K
E
G
D
Y
V
M
L
V
N
Q
D
G
V
K
E
--
G
--
P
V
R
V
K
P
T
--
A
R
I
R
K
D
C
--
V
Y
I
----------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
77.59
24%
-40
- C1 -
2VPY
4
?
A:
[30-695]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
W
Y
A
Q
E
V
K
S
V
Y
Q
I
-
C
E
G
C
F
--
W
R
C
G
I
V
A
H
A
V
G
N
-------------------------------------------
R
V
Y
K
V
E
G
-------
Y
E
A
N
P
K
S
-------
R
G
R
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
-----
P
-----
D
R
L
K
R
P
L
I
R
VEGSQR-
G
----
E
--------------------------------------
G
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
-
L
E
I
R
E
K
Y
G
P
E
A
I
A
F
F
----
G
H
----
G
T
G
----
D
Y
W
F
V
D
F
L
P
A
A
W
G
S
P
N
A
A
K
P
-----
S
V
S
L
C
T
A
P
R
E
V
A
S
Q
W
V
F
-----
G
R
P
I
G
G
H
E
PI
D
W
E
N
A
R
Y
I
V
L
I
G
H
H
I
G
E
D
T
-
H
N
T
Q
L
--
Q
-----------
D
F
A
---
L
------------
A
L
K
---
N
G
A
-----
K
V
--
V
V
V
D
P
R
F
S
T
A
A
A
K
A
--------
H
R
W
--------
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
------
D
L
Y
D
K
E
Y
V
A
K
Y
T
V
----------------------------------------------------------------------
G
---------
F
E
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
H
V
K
D
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
R
E
M
A
A
H
------
K
-
P
------
R
A
V
------
L
P
P
-
T
R
H
N
V
WY
G
D
D
T
Y
R
V
M
A
L
L
Y
V
N
V
L
L
G
N
Y
G
R
P
G
-------------
G
F
Y
I
A
Q
S
P
Y
L
E
K
YPLPPLP
L
E
------------
P
A
A
-
G
G
C
S
-
G
-
P
S
G
G
D
---------
H
--
E
P
----
E
G
-----------------
F
K
P
--
R
A
-----
D
K
G
K
-
F
-
F
------------
A
R
S
----
T
A
I
---
Q
----------------------------------------------------
E
L
I
----------
E
P
M
I
--------------
T
G
E
PYP
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
------------------------------
V
P
--
R
-
T
K
--
E
A
-------------------------------
L
K
----
N
L
----
D
-
L
Y
V
A
I
D
V
L
P
--
Q
E
-
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
Y
D
D
F
V
L
V
---
A
H
K
T
P
F
I
Q
L
R
T
P
A
H
E
P
L
F
D
T
K
P
G
-
W
W
I
A
R
E
L
G
L
R
L
G
L
E
---------------
Q
------
Y
---------------
F
-------------------------
P
W
----------
K
T
-----------------------------------
I
E
-----------
E
---
Y
------
L
E
---
T
R
-------------
L
-------------------------
Q
------------
S
--------
L
----
G
L
-----------------------------------------------------
D
L
E
T
----------------
M
--------------------
K
-----
G
---------------------------
M
------------------------------
G
T
--
L
V
Q
R
G
-------------
K
P
--
W
L
-
E
D
W
-----
E
K
----------
E
G
---------------
R
---
L
P
---------------
F
G
-------------
T
---
A
S
G
K
I
E
L
Y
C
Q
R
F
------------
K
------------
E
------
A
----
G
----
H
-------------
Q
PLPVFTP
P
E
E
P
P
E
G
F
Y
R
L
L
Y
G
R
S
P
V
----
H
T
F
A
R
T
Q
N
N
W
V
L
M
E
M
D
-
P
E
N
E
V
W
I
H
K
E
E
A
K
R
L
G
L
K
E
G
D
Y
V
M
L
V
N
Q
D
G
VK
E
--
G
--
P
V
R
V
K
P
T
--
A
R
I
R
K
D
C
--
V
Y
I
----------------------------------------------------------------------------------------------------------------------------------------------