@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2122: (2016-04-01 )
MRKIQAKKGLSIECKGWEQEAVLRMLYNNLDPEVAERPEDLVVYGGIGKAARNWEAFEAIEKTLRELESDETMLVQSGKPVAVFKTHEEAPRVLISNSVLVPEWANWDHFNELDKKGLIMYGQMTAGSWIYIGSQGIVQGTYETFAELGNQHFNGDLAGTVTLTAGLGGMGGAQPLAITMNHGVAICVDVDETRVDKRIDTKYCDVKTADLDEALKLAEEAKERGEGLSIGLVGNAVDIHQAILEKGFKIDIITDQTSAHDPLNGYVPQGYSVEEAKVLREKDPKKYVELSQASMAKHVELMLEFQKRGAVAFDYGNNIRQVAFNNGVKNAFDFPGFVPAYIRPLFCEGKGPFRFAALSGDPKDIERADEEMRKLFPENEKLLRWLDLAEEKISYQGLPSRIAWLGYGERAKMGLALNRLVRDGEISAPIVIGRDHLDAGSVASPNRETESMKDGSDAVGDWAVLNALINTAAGGSWISFHHGGGVGMGYSLHAGMVVVADGSERAERRLERVLTTDPGMGVARHVDAGYDIAIQTAKEKGIHIPMIDKAGDK
Atome Classification :
(20 SA)
----------------------------.........10........---20........30........40........50........60..---------......70........80........------90-.........100.------......110.......120.......130...-....140.......150.......160.......170--------------........180..-----.....190-.........200.......210.......220.....-------.--.230....--...240.......250.......260.......270.......280.......290.......300.......310.......320-----........330....---...340.......350--------.-......360.......370------------........380--..------....----.390.....-------..400.......410--.......420.......430.......440.--......450--------.......460.......470--.........480..---.....490.......500.......510........520---........530.......540.......550.------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------MRKIQAKKG
L
S
I
E
CKGW
E
Q
---
E
A
V
L
R
M
L
Y
NNL
D
P
E
V
AERPE
D
L
V
V
YGGIGKAARN
W
E
A
F
E
A
I
E
K
T
---------
L
R
E
LESD
E
T
M
L
VQSGK
P
V
A
V
F
KTHEE------A--
P
R
V
L
ISN
S
V
LVPE------WANW
D
H
F
N
E
LDKK
G
L
I
M
Y
G
QMTAG
S
W
I
Y
IGSQ-GIVQ
G
T
Y
E
T
F
A
E
LGNQHFNGDL
A
G
T
V
T
L
T
AGLGGMG---------------GA
Q
P
L
A
I
T
MNH
G
V
-----
A
I
C
V
DV---
D
E
T
R
VDKRIDTKYCDVKTA
D
L
D
E
A
L
K
L
A
E
E
A
K
ERGEG-------
L
--
S
I
G
L
VG
N
A
--
V
D
I
H
Q
A
I
L
EKG
F
K
I
D
I
I
TDQTSAHDPLNGYVPQGY
S
V
E
E
A
K
V
L
R
E
K
D
P
K
K
Y
V
E
L
S
Q
A
S
M
A
K
H
V
E
L
M
L
E
F
Q
KR
G
A
V
A
F
DYGNN
I
R
Q
------
V
A
FNNGVKNAFDFPG---F
V
P
A
Y
I
R
P
L
F
CEGKG
P
--------
F
-
R
F
A
ALSG
D
P
K
D
I
E
R
A
D
E
E
-------------
M
R
K
LFPE
N
E
K
L
--
L
R
------
W
L
D
L
----
A
E
E
K
ISYQG-------L
P
S
R
I
A
WLGYG
E
R
A
K
--
M
G
L
A
L
N
R
L
V
RDGEISA
P
I
V
I
GRDHLDAGSVA--SPNRETESM--------KDGSDAV
G
D
W
A
V
L
N
A
L
I
N----TAAGG
S
W
I
S
F
HHGG---GVGM
G
Y
S
LHA
G
M
V
V
V
AD
G
S
E
R
A
E
R
R
L
-
E
R
V
LTTDPGMG----
V
A
RHVDAG
Y
D
I
A
I
Q
TAKEKGIHIPMIDKAGDK------------
27
HHSearch
97.62
72%
-76
- C7 -
2FKN
2
HUTU_BACSU
A:
[7-550]
------------------------------
S
I
R
A
N
R
G
T
E
L
E
C
L
G
W
E
Q
---
E
A
V
L
R
M
L
R
N
N
L
D
P
E
V
A
E
K
P
E
D
L
I
V
Y
G
G
I
G
K
A
A
R
D
W
D
A
F
H
A
I
E
H
S
---------
L
K
T
L
K
N
D
E
T
L
L
V
Q
S
G
K
P
V
G
M
F
R
T
H
P
Q
------
A
--
P
R
V
L
L
A
N
S
V
L
V
P
K
------
W
A
D
W
E
H
F
H
E
L
E
K
K
G
L
M
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
-
G
I
L
Q
G
T
Y
E
T
F
A
E
L
A
R
Q
H
F
G
G
S
L
K
G
T
L
T
L
T
A
G
L
G
G
M
G
---------------
G
A
Q
P
L
S
V
T
M
N
E
G
V
-----
V
I
A
V
E
V
---
D
E
K
R
I
D
K
R
I
E
T
K
Y
C
D
R
K
T
A
S
I
E
E
A
L
A
W
A
E
E
A
K
L
A
G
K
P
-------
L
--
S
I
A
L
L
G
N
A
--
A
E
V
H
H
T
L
L
N
R
G
V
K
I
D
I
V
T
D
Q
T
S
A
H
D
P
L
I
G
Y
V
P
E
G
Y
S
L
D
E
A
D
R
L
R
Q
D
T
P
E
L
Y
V
R
L
A
K
Q
S
M
K
K
H
V
E
A
M
L
A
F
Q
Q
K
G
S
I
V
F
D
Y
G
N
N
I
R
Q
------
V
A
K
D
E
G
L
E
N
A
F
D
F
P
G
---
F
V
P
A
Y
I
R
P
L
F
C
E
G
K
G
P
--------
F
-
R
W
A
A
L
S
G
D
P
A
D
I
Y
R
T
D
A
L
-------------
L
K
E
L
F
P
T
N
K
A
L
--
H
R
------
W
I
D
M
----
A
Q
E
K
V
T
F
Q
G
-------
L
P
S
R
I
C
W
L
G
Y
G
E
R
K
K
--
M
G
L
A
I
N
E
L
V
R
T
G
E
L
K
A
P
V
V
I
G
R
D
H
L
D
C
G
S
V
A
--
S
P
N
R
E
T
E
A
M
--------
K
D
G
S
D
A
V
G
D
W
A
V
L
N
A
L
V
N
----
T
A
A
G
A
S
W
V
S
F
H
H
G
G
---
G
V
G
M
G
Y
S
L
H
A
G
M
V
A
V
A
D
G
S
E
L
A
D
E
R
L
-
A
R
V
L
T
S
D
P
G
M
G
----
I
I
R
H
A
D
A
G
Y
E
R
A
V
E
V
A
K
E
Q
D
I
I
V
P
M
-------------------
1
PsiBlast_PDB
97.62
72%
-76
- C7 -
2FKN
2
HUTU_BACSU
A:
[7-550]
------------------------------
S
I
R
A
N
R
G
T
E
L
E
C
L
G
W
E
Q
---
E
A
V
L
R
M
L
R
N
N
L
D
P
E
V
A
E
K
P
E
D
L
I
V
Y
G
G
I
G
K
A
A
R
D
W
D
A
F
H
A
I
E
H
S
---------
L
K
T
L
K
N
D
E
T
L
L
V
Q
S
G
K
P
V
G
M
F
R
T
H
P
Q
------
A
--
P
R
V
L
L
A
N
S
V
L
V
P
K
------
W
A
D
W
E
H
F
H
E
L
E
K
K
G
L
M
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
-
G
I
L
Q
G
T
Y
E
T
F
A
E
L
A
R
Q
H
F
G
G
S
L
K
G
T
L
T
L
T
A
G
L
G
G
M
G
---------------
G
A
Q
P
L
S
V
T
M
N
E
G
V
-----
V
I
A
V
E
V
---
D
E
K
R
I
D
K
R
I
E
T
K
Y
C
D
R
K
T
A
S
I
E
E
A
L
A
W
A
E
E
A
K
L
A
G
K
P
-------
L
--
S
I
A
L
L
G
N
A
--
A
E
V
H
H
T
L
L
N
R
G
V
K
I
D
I
V
T
D
Q
T
S
A
H
D
P
L
I
G
Y
V
P
E
G
Y
S
L
D
E
A
D
R
L
R
Q
D
T
P
E
L
Y
V
R
L
A
K
Q
S
M
K
K
H
V
E
A
M
L
A
F
Q
Q
K
G
S
I
V
F
D
Y
G
N
N
I
R
Q
------
V
A
K
D
E
G
L
E
N
A
F
D
F
P
G
---
F
V
P
A
Y
I
R
P
L
F
C
E
G
K
G
P
--------
F
-
R
W
A
A
L
S
G
D
P
A
D
I
Y
R
T
D
A
L
-------------
L
K
E
L
F
P
T
N
K
A
L
--
H
R
------
W
I
D
M
----
A
Q
E
K
V
T
F
Q
G
-------
L
P
S
R
I
C
W
L
G
Y
G
E
R
K
K
--
M
G
L
A
I
N
E
L
V
R
T
G
E
L
K
A
P
V
V
I
G
R
D
H
L
D
C
G
S
V
A
--
S
P
N
R
E
T
E
A
M
--------
K
D
G
S
D
A
V
G
D
W
A
V
L
N
A
L
V
N
----
T
A
A
G
A
S
W
V
S
F
H
H
G
G
---
G
V
G
M
G
Y
S
L
H
A
G
M
V
A
V
A
D
G
S
E
L
A
D
E
R
L
-
A
R
V
L
T
S
D
P
G
M
G
----
I
I
R
H
A
D
A
G
Y
E
R
A
V
E
V
A
K
E
Q
D
I
I
V
P
M
-------------------
18
PsiBlast_CBE
97.41
72%
-77
- C7 -
2FKN
2
HUTU_BACSU
B:
[7-550]
------------------------------
S
I
R
A
N
R
G
T
E
L
E
C
L
G
W
E
Q
---
E
A
V
L
R
M
L
R
N
N
L
D
P
E
V
A
E
K
P
E
D
L
I
V
Y
G
G
I
G
K
A
A
R
D
W
D
A
F
H
A
I
E
H
S
---------
L
K
T
L
K
N
D
E
T
L
L
V
Q
S
G
K
P
V
G
M
F
R
T
H
P
Q
------
A
--
P
R
V
L
L
A
N
S
V
L
V
P
K
------
W
A
D
W
E
H
F
H
E
L
E
K
K
G
L
M
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
-
G
I
L
Q
G
T
Y
E
T
F
A
E
L
A
R
Q
H
F
G
G
S
L
K
G
T
L
T
L
T
A
G
L
G
G
M
G
---------------
G
A
Q
P
L
S
V
T
M
N
E
G
V
-----
V
I
A
V
E
V
---
D
E
K
R
I
D
K
R
I
E
T
K
Y
C
D
R
K
T
A
S
I
E
E
A
L
A
W
A
E
E
A
K
L
A
G
K
P
-------
L
--
S
I
A
L
L
G
N
A
--
A
E
V
H
H
T
L
L
N
R
G
V
K
I
D
I
V
T
D
Q
T
S
A
H
D
P
L
I
G
Y
V
P
E
G
Y
S
L
D
E
A
D
R
L
R
Q
D
T
P
E
L
Y
V
R
L
A
K
Q
S
M
K
K
H
V
E
A
M
L
A
F
Q
Q
K
G
S
I
V
F
D
Y
G
N
N
I
R
Q
------
V
A
K
D
E
G
L
E
N
A
F
D
F
P
G
---
F
V
P
A
Y
I
R
P
L
F
C
E
G
K
G
P
--------
F
-
R
W
A
A
L
S
G
D
P
A
D
I
Y
R
T
D
A
L
-------------
L
K
E
L
F
P
T
N
K
A
L
--
H
R
------
W
I
D
M
----
A
Q
E
K
V
T
F
Q
G
-------
L
P
S
R
I
C
W
L
G
Y
G
E
R
K
K
--
M
G
L
A
I
N
E
L
V
R
T
G
E
L
K
A
P
V
V
I
G
R
D
H
L
D
C
G
S
V
A
--
S
P
N
R
E
T
E
A
M
--------
K
D
G
S
D
A
V
G
D
W
A
V
L
N
A
L
V
N
----
T
A
A
G
A
S
W
V
S
F
H
H
G
G
---
G
V
G
M
G
Y
S
L
H
A
G
M
V
A
V
A
D
G
S
E
L
A
D
E
R
L
-
A
R
V
L
T
S
D
P
G
M
G
----
I
I
R
H
A
D
A
G
Y
E
R
A
V
E
V
A
K
E
Q
D
I
I
V
P
M
-------------------
16
PsiBlast_CBE
97.27
72%
-76
- C7 -
2FKN
2
HUTU_BACSU
D:
[7-550]
------------------------------
S
I
R
A
N
R
G
T
E
L
E
C
L
G
W
E
Q
---
E
A
V
L
R
M
L
R
N
N
L
D
P
E
V
A
E
K
P
E
D
L
I
V
Y
G
G
I
G
K
A
A
R
D
W
D
A
F
H
A
I
E
H
S
---------
L
K
T
L
K
N
D
E
T
L
L
V
Q
S
G
K
P
V
G
M
F
R
T
H
P
Q
------
A
--
P
R
V
L
L
A
N
S
V
L
V
P
K
------
W
A
D
W
E
H
F
H
E
L
E
K
K
G
L
M
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
-
G
I
L
Q
G
T
Y
E
T
F
A
E
L
A
R
Q
H
F
G
G
S
L
K
G
T
L
T
L
T
A
G
L
G
G
M
G
---------------
G
A
Q
P
L
S
V
T
M
N
E
G
V
-----
V
I
A
V
E
V
---
D
E
K
R
I
D
K
R
I
E
T
K
Y
C
D
R
K
T
A
S
I
E
E
A
L
A
W
A
E
E
A
K
L
A
G
K
P
-------
L
--
S
I
A
L
L
G
N
A
--
A
E
V
H
H
T
L
L
N
R
G
V
K
I
D
I
V
T
D
Q
T
S
A
H
D
P
L
I
G
Y
V
P
E
G
Y
S
L
D
E
A
D
R
L
R
Q
D
T
P
E
L
Y
V
R
L
A
K
Q
S
M
K
K
H
V
E
A
M
L
A
F
Q
Q
K
G
S
I
V
F
D
Y
G
N
N
I
R
Q
------
V
A
K
D
E
G
L
E
N
A
F
D
F
P
G
---
F
V
P
A
Y
I
R
P
L
F
C
E
G
K
G
P
--------
F
-
R
W
A
A
L
S
G
D
P
A
D
I
Y
R
T
D
A
L
-------------
L
K
E
L
F
P
T
N
K
A
L
--
H
R
------
W
I
D
M
----
A
Q
E
K
V
T
F
Q
G
-------
L
P
S
R
I
C
W
L
G
Y
G
E
R
K
K
--
M
G
L
A
I
N
E
L
V
R
T
G
E
L
K
A
P
V
V
I
G
R
D
H
L
D
C
G
S
V
A
--
S
P
N
R
E
T
E
A
M
--------
K
D
G
S
D
A
V
G
D
W
A
V
L
N
A
L
V
N
----
T
A
A
G
A
S
W
V
S
F
H
H
G
G
---
G
V
G
M
G
Y
S
L
H
A
G
M
V
A
V
A
D
G
S
E
L
A
D
E
R
L
-
A
R
V
L
T
S
D
P
G
M
G
----
I
I
R
H
A
D
A
G
Y
E
R
A
V
E
V
A
K
E
Q
D
I
I
V
P
M
-------------------
17
PsiBlast_CBE
97.24
72%
-74
- C7 -
2FKN
2
HUTU_BACSU
C:
[7-550]
------------------------------
S
I
R
A
N
R
G
T
E
L
E
C
L
G
W
E
Q
---
E
A
V
L
R
M
L
R
N
N
L
D
P
E
V
A
E
K
P
E
D
L
I
V
Y
G
G
I
G
K
A
A
R
D
W
D
A
F
H
A
I
E
H
S
---------
L
K
T
L
K
N
D
E
T
L
L
V
Q
S
G
K
P
V
G
M
F
R
T
H
P
Q
------
A
--
P
R
V
L
L
A
N
S
V
L
V
P
K
------
W
A
D
W
E
H
F
H
E
L
E
K
K
G
L
M
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
-
G
I
L
Q
G
T
Y
E
T
F
A
E
L
A
R
Q
H
F
G
G
S
L
K
G
T
L
T
L
T
A
G
L
G
G
M
G
---------------
G
A
Q
P
L
S
V
T
M
N
E
G
V
-----
V
I
A
V
E
V
---
D
E
K
R
I
D
K
R
I
E
T
K
Y
C
D
R
K
T
A
S
I
E
E
A
L
A
W
A
E
E
A
K
L
A
G
K
P
-------
L
--
S
I
A
L
L
G
N
A
--
A
E
V
H
H
T
L
L
N
R
G
V
K
I
D
I
V
T
D
Q
T
S
A
H
D
P
L
I
G
Y
V
P
E
G
Y
S
L
D
E
A
D
R
L
R
Q
D
T
P
E
L
Y
V
R
L
A
K
Q
S
M
K
K
H
V
E
A
M
L
A
F
Q
Q
K
G
S
I
V
F
D
Y
G
N
N
I
R
Q
------
V
A
K
D
E
G
L
E
N
A
F
D
F
P
G
---
F
V
P
A
Y
I
R
P
L
F
C
E
G
K
G
P
--------
F
-
R
W
A
A
L
S
G
D
P
A
D
I
Y
R
T
D
A
L
-------------
L
K
E
L
F
P
T
N
K
A
L
--
H
R
------
W
I
D
M
----
A
Q
E
K
V
T
F
Q
G
-------
L
P
S
R
I
C
W
L
G
Y
G
E
R
K
K
--
M
G
L
A
I
N
E
L
V
R
T
G
E
L
K
A
P
V
V
I
G
R
D
H
L
D
C
G
S
V
A
--
S
P
N
R
E
T
E
A
M
--------
K
D
G
S
D
A
V
G
D
W
A
V
L
N
A
L
V
N
----
T
A
A
G
A
S
W
V
S
F
H
H
G
G
---
G
V
G
M
G
Y
S
L
H
A
G
M
V
A
V
A
D
G
S
E
L
A
D
E
R
L
-
A
R
V
L
T
S
D
P
G
M
G
----
I
I
R
H
A
D
A
G
Y
E
R
A
V
E
V
A
K
E
Q
D
I
I
V
P
M
-------------------
22
PsiBlast_CBE
95.15
62%
-77
- C7 -
2V7G
8
HUTU_PSEPU
D:
[11-555]
------------------------------
E
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
---
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
---------
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
------
A
--
P
R
V
L
I
A
N
S
N
L
V
P
H
------
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
-
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
---------------
G
A
Q
P
L
A
A
T
L
A
G
A
C
-----
S
L
N
I
E
S
---
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
-------
I
--
S
I
A
L
H
G
N
A
--
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
I
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
I
P
A
A
V
V
K
A
A
K
A
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
------
M
A
K
E
E
G
V
A
N
A
F
D
F
P
G
---
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
--------
F
-
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
-------------
V
K
E
L
I
P
D
D
A
H
L
--
H
R
------
W
L
D
M
----
A
R
E
R
I
S
F
Q
G
-------
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
--
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
--
S
P
N
R
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
---
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
-
A
R
V
L
T
N
D
P
G
T
G
----
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
------------------
23
PsiBlast_CBE
94.94
62%
-78
- C7 -
2V7G
3
HUTU_PSEPU
C:
[11-555]
------------------------------
E
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
---
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
---------
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
------
A
--
P
R
V
L
I
A
N
S
N
L
V
P
H
------
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
-
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
---------------
G
A
Q
P
L
A
A
T
L
A
G
A
C
-----
S
L
N
I
E
S
---
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
-------
I
--
S
I
A
L
H
G
N
A
--
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
I
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
I
P
A
A
V
V
K
A
A
K
A
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
------
M
A
K
E
E
G
V
A
N
A
F
D
F
P
G
---
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
--------
F
-
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
-------------
V
K
E
L
I
P
D
D
A
H
L
--
H
R
------
W
L
D
M
----
A
R
E
R
I
S
F
Q
G
-------
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
--
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
--
S
P
N
R
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
---
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
-
A
R
V
L
T
N
D
P
G
T
G
----
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
------------------
24
PsiBlast_CBE
94.45
62%
-74
- C7 -
2V7G
7
HUTU_PSEPU
B:
[11-555]
------------------------------
E
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
---
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
---------
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
------
A
--
P
R
V
L
I
A
N
S
N
L
V
P
H
------
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
-
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
---------------
G
A
Q
P
L
A
A
T
L
A
G
A
C
-----
S
L
N
I
E
S
---
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
-------
I
--
S
I
A
L
H
G
N
A
--
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
I
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
I
P
A
A
V
V
K
A
A
K
A
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
------
M
A
K
E
E
G
V
A
N
A
F
D
F
P
G
---
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
--------
F
-
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
-------------
V
K
E
L
I
P
D
D
A
H
L
--
H
R
------
W
L
D
M
----
A
R
E
R
I
S
F
Q
G
-------
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
--
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
--
S
P
N
R
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
---
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
-
A
R
V
L
T
N
D
P
G
T
G
----
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
------------------
5
PsiBlast_PDB
94.24
62%
-73
- C7 -
2V7G
5
HUTU_PSEPU
A:
[11-555]
------------------------------
E
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
---
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
---------
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
------
A
--
P
R
V
L
I
A
N
S
N
L
V
P
H
------
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
-
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
---------------
G
A
Q
P
L
A
A
T
L
A
G
A
C
-----
S
L
N
I
E
S
---
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
-------
I
--
S
I
A
L
H
G
N
A
--
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
I
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
I
P
A
A
V
V
K
A
A
K
A
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
------
M
A
K
E
E
G
V
A
N
A
F
D
F
P
G
---
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
--------
F
-
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
-------------
V
K
E
L
I
P
D
D
A
H
L
--
H
R
------
W
L
D
M
----
A
R
E
R
I
S
F
Q
G
-------
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
--
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
--
S
P
N
R
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
---
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
-
A
R
V
L
T
N
D
P
G
T
G
----
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
------------------
20
PsiBlast_CBE
94.18
61%
-90
- C- -
1W1U
2
HUTU_PSEPU
B:
[11-555]
------------------------------
E
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
---
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
---------
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
------
A
--
P
R
V
L
I
A
N
S
N
L
V
P
H
------
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
-
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
---------------
G
A
Q
P
L
A
A
T
L
A
G
A
C
-----
S
L
N
I
E
S
---
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
-------
I
--
S
I
A
L
H
G
N
A
--
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
------
M
A
K
E
E
G
V
A
N
A
F
D
F
P
G
---
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
--------
F
-
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
-------------
V
K
E
L
I
P
D
D
A
H
L
--
H
R
------
W
L
D
M
----
A
R
E
R
I
S
F
Q
G
-------
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
--
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
--
S
P
N
A
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
---
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
-
A
R
V
L
T
N
D
P
G
T
G
----
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
------------------
2
PsiBlast_PDB
93.93
61%
-89
- C- -
1UWL
1
HUTU_PSEPU
A:
[11-555]
------------------------------
E
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
---
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
---------
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
------
A
--
P
R
V
L
I
A
N
S
N
L
V
P
H
------
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
-
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
---------------
G
A
Q
P
L
A
A
T
L
A
G
A
C
-----
S
L
N
I
E
S
---
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
-------
I
--
S
I
A
L
H
G
N
A
--
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
------
M
A
K
E
E
G
V
A
N
A
F
D
F
P
G
---
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
--------
F
-
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
-------------
V
K
E
L
I
P
D
D
A
H
L
--
H
R
------
W
L
D
M
----
A
R
E
R
I
S
F
Q
G
-------
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
--
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
--
S
P
N
R
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
---
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
-
A
R
V
L
T
N
D
P
G
T
G
----
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
------------------
46
Fugue
93.90
61%
-74
- C7 -
1UWK
2
HUTU_PSEPU
A:
[4-557]
-----------------------NNKYR
D
V
E
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
---
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
---------
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
------
A
--
P
R
V
L
I
A
N
S
N
L
V
P
H
------
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
-
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
---------------
G
A
Q
P
L
A
A
T
L
A
G
A
C
-----
S
L
N
I
E
S
---
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
-------
I
--
S
I
A
L
H
G
N
A
--
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
------
M
A
K
E
E
G
V
A
D
A
F
D
F
P
G
---
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
--------
F
-
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
-------------
V
K
E
L
I
P
D
D
A
H
L
--
H
R
------
W
L
D
M
----
A
R
E
R
I
S
F
Q
G
-------
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
--
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
--
S
P
N
A
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
---
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
-
A
R
V
L
T
N
D
P
G
T
G
----
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
T
G
----------------
19
PsiBlast_CBE
93.90
61%
-74
- C7 -
1UWL
1
HUTU_PSEPU
B:
[11-554]
------------------------------
E
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
---
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
---------
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
------
A
--
P
R
V
L
I
A
N
S
N
L
V
P
H
------
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
-
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
---------------
G
A
Q
P
L
A
A
T
L
A
G
A
C
-----
S
L
N
I
E
S
---
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
-------
I
--
S
I
A
L
H
G
N
A
--
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
------
M
A
K
E
E
G
V
A
N
A
F
D
F
P
G
---
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
--------
F
-
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
-------------
V
K
E
L
I
P
D
D
A
H
L
--
H
R
------
W
L
D
M
----
A
R
E
R
I
S
F
Q
G
-------
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
--
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
--
S
P
N
R
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
---
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
-
A
R
V
L
T
N
D
P
G
T
G
----
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
-------------------
26
HHSearch
93.64
61%
-74
- C7 -
1UWK
2
HUTU_PSEPU
A:
[10-556]
-----------------------------
V
E
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
---
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
---------
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
------
A
--
P
R
V
L
I
A
N
S
N
L
V
P
H
------
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
-
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
---------------
G
A
Q
P
L
A
A
T
L
A
G
A
C
-----
S
L
N
I
E
S
---
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
-------
I
--
S
I
A
L
H
G
N
A
--
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
------
M
A
K
E
E
G
V
A
D
A
F
D
F
P
G
---
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
--------
F
-
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
-------------
V
K
E
L
I
P
D
D
A
H
L
--
H
R
------
W
L
D
M
----
A
R
E
R
I
S
F
Q
G
-------
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
--
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
--
S
P
N
A
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
---
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
-
A
R
V
L
T
N
D
P
G
T
G
----
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
T
-----------------
4
PsiBlast_PDB
93.49
61%
-74
- C7 -
1UWK
2
HUTU_PSEPU
A:
[11-555]
------------------------------
E
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
---
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
---------
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
------
A
--
P
R
V
L
I
A
N
S
N
L
V
P
H
------
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
-
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
---------------
G
A
Q
P
L
A
A
T
L
A
G
A
C
-----
S
L
N
I
E
S
---
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
-------
I
--
S
I
A
L
H
G
N
A
--
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
------
M
A
K
E
E
G
V
A
D
A
F
D
F
P
G
---
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
--------
F
-
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
-------------
V
K
E
L
I
P
D
D
A
H
L
--
H
R
------
W
L
D
M
----
A
R
E
R
I
S
F
Q
G
-------
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
--
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
--
S
P
N
A
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
---
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
-
A
R
V
L
T
N
D
P
G
T
G
----
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
------------------
21
PsiBlast_CBE
93.43
61%
-74
- C7 -
1UWK
2
HUTU_PSEPU
B:
[11-555]
------------------------------
E
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
---
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
---------
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
------
A
--
P
R
V
L
I
A
N
S
N
L
V
P
H
------
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
-
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
---------------
G
A
Q
P
L
A
A
T
L
A
G
A
C
-----
S
L
N
I
E
S
---
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
-------
I
--
S
I
A
L
H
G
N
A
--
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
------
M
A
K
E
E
G
V
A
D
A
F
D
F
P
G
---
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
--------
F
-
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
-------------
V
K
E
L
I
P
D
D
A
H
L
--
H
R
------
W
L
D
M
----
A
R
E
R
I
S
F
Q
G
-------
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
--
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
--
S
P
N
A
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
---
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
-
A
R
V
L
T
N
D
P
G
T
G
----
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
------------------
3
PsiBlast_PDB
93.22
61%
-90
- C- -
1W1U
2
HUTU_PSEPU
A:
[11-555]
------------------------------
E
I
R
A
P
R
G
N
K
L
T
A
K
S
W
L
T
---
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
D
K
I
V
E
T
---------
L
T
R
L
E
D
D
E
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
------
A
--
P
R
V
L
I
A
N
S
N
L
V
P
H
------
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
-
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
---------------
G
A
Q
P
L
A
A
T
L
A
G
A
C
-----
S
L
N
I
E
S
---
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
A
K
Y
T
A
E
G
K
A
-------
I
--
S
I
A
L
H
G
N
A
--
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
H
V
Q
A
M
L
D
F
Q
K
Q
G
V
P
T
F
D
Y
G
N
N
I
R
Q
------
M
A
K
E
E
G
V
A
N
A
F
D
F
P
G
---
F
V
P
A
Y
I
R
P
L
F
C
R
G
V
G
P
--------
F
-
R
W
A
A
L
S
G
E
A
E
D
I
Y
K
T
D
A
K
-------------
V
K
E
L
I
P
D
D
A
H
L
--
H
R
------
W
L
D
M
----
A
R
E
R
I
S
F
Q
G
-------
L
P
A
R
I
C
W
V
G
L
G
L
R
A
K
--
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
--
S
P
N
A
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
---
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
D
E
A
A
E
R
I
-
A
R
V
L
T
N
D
P
G
T
G
----
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
------------------
53
Fugue
40.19
18%
-37
- C2 -
4M59
3
?
A:
[6-714]
PD
A
Q
V
L
V
L
A
I
S
S
HPLPT
L
A
A
F
L
A
S
R
R
D
E
L
L
R
A
D
I
T
S
L
L
K
A
L
E
L
S
G
H
W
---
E
W
A
L
A
L
L
R
W
A
G
K
E
G
A
A
D
A
S
A
L
E
M
V
V
R
A
L
G
R
E
G
Q
H
D
A
V
C
A
L
L
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A-----------
52
Fugue
40.14
15%
4
- C6 -
5CWW
-
?
B:
[3-593]
----------------------------
K
I
K
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A
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L
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---
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---
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-------
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--------
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----
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F
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---------------
51
Fugue
37.78
13%
-21
* C6 *
2JG0
1
TREA_ECOLI
A:
[7-517]
-----------------PQP
P
D
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A
K
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------
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---
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T
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------
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L
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V
P
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----------
G
R
F
R
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----
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-----
L
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-------------------
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---
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--------
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N
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-------
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A
A
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--
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A
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K
T
H
L
L
Q
P
------------
G
G
L
N
--
T
T
S
V
K
S
G
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--------
W
D
A
P
N
G
---
W
A
P
L
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W
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A
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----
E
G
L
Q
-------
N
Y
G
---
Q
K
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A
M
D
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W
H
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T
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V
Q
H
T
Y
D
R
E
K
K
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T
T
G
T
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----
G
G
G
G
---
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