@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2132: (2016-04-01 )
MGLVIEHVTKRFGKMTAVNDISLELESGKMLGFLGRNGAGKTTTFRMILGLSEPTEGHITYNGKKLDKTMYNRIGYLPEERGLHGKLTVEEELKYLATLKGMSKTEIQQQISYWLERFDITENRKKRIDSLSKGNQQKIQLLASMLHKPELLILDEPFSGLDPVNVELLKEAVKDLNDWGSTIVYSSHRMEHVEELCDDVCILDKGQLVVSGDINHVRASNGNKKVVIESETTLPDLTNIRGIIHSENMKQGLQLTIENEDVAKDIYQVVAHQGYVKRFQVVEPSLQDIFIEKVGGKDA
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10.--..--.....---20........30........40........50........60-------...-----..---.-------..70.------.--......80......---------..90....-....------100........110......-.120...-------....130.......140.......150.......160-.......170.....-.-.-180.......190.......200.......-------------------210.......220....--------...---230.......240.--......250---------------.........260..------.....270.......280.......290.......-----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MG
L
V
I
E
H
V
T
K
RF--GK--
M
T
A
V
N
---
D
I
S
L
E
LES
G
K
M
L
G
F
LGRNGAGKT
T
T
F
R
M
I
LGLSEPTE
G
H
I
T
Y-------N
G
K
-----
K
L
---
D
-------
K
T
M
Y
N
------R--IGYLPEERGLHG
K
L
---------
T
V
E
E
E
L
K
Y
-
L
A
T
L------KG-M
S
K
T
E
I
Q
Q
Q
I
S
Y
W
L
E
RF-DI
T
E
N
R
K
-------
K
R
I
D
S
LSKG
N
Q
Q
K
I
Q
L
L
A
S
M
LHKP
E
L
L
I
LDEPFSGLD-PV
N
V
E
L
L
K
E
A
V
K
D
L
N
-D-W-G
S
T
I
V
Y
S
S
H
R
M
E
H
V
E
E
L
CDD
V
C
I
LDKG
Q
L
V
-------------------
V
SGDI
N
H
V
RASNG
N
K
K
V
--------
V
IE---SETTLP
D
L
T
N
I
R
G
I
--IH
S
E
N
MK-----------------QG
L
Q
L
T
IE
N
E
D
V
A
K
------
D
I
Y
Q
V
V
AHQ
G
Y
V
K
R
F
QVVEP
S
L
Q
D
I
F
I
E
KVGGKDA-----------------------------
10
PsiBlast_PDB
87.83
29%
-77
- C1 -
1OXU
7
?
A:
[4-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
V
K
N
V
S
K
V
F
KK
G
K
--
V
V
A
L
D
---
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
DDRLVAS
N
G
K
-----
L
I
---
V
-------
P
P
E
D
R
------
K
--
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
---------
T
A
F
E
N
I
A
F
-
P
L
T
N
------
M
K
-
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
-
D
I
H
H
V
L
N
-------
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
-
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
-
S
R
L
-
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
QVGK
P
E
D
L
Y
D
NPVS
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
--------
V
I
G
---
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
-----------------
L
-------
S
K
D
V
I
K
------
D
D
S
W
I
L
V
G
K
G
K
V
K
---------------------------------------------------
9
PsiBlast_PDB
87.19
29%
-75
- C1 -
1OXT
-
?
A:
[4-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
V
K
N
V
S
K
V
F
KK
G
K
--
V
V
A
L
D
---
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
DDRLVAS
N
G
K
-----
L
I
---
V
-------
P
P
E
D
R
------
K
--
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
---------
T
A
F
E
N
I
A
F
-
P
L
T
N
------
M
K
-
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
-
D
I
H
H
V
L
N
-------
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
-
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
-
S
R
L
-
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
QVGK
P
E
D
L
Y
D
N
PVS
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
--------
V
I
G
---
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
-----------------
L
-------
S
K
D
V
I
K
------
D
D
S
W
I
L
V
G
K
G
K
V
K
---------------------------------------------------
8
PsiBlast_PDB
86.91
29%
-73
- C1 -
1OXS
20
?
C:
[4-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
V
K
N
V
S
K
V
F
KK
G
K
--
V
V
A
L
D
---
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
DDRLVAS
N
G
K
-----
L
I
---
V
-------
P
P
E
D
R
------
K
--
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
---------
T
A
F
E
N
I
A
F
-
P
L
T
N
------
M
K
-
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
-
D
I
H
H
V
L
N
-------
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
-
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
-
S
R
L
-
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
QVGKPEDLYDNPVSIQVAS
L
I
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
--------
V
I
G
---
S
L
R
F
P
V
S
V
S
S
D
R
A
I
IG
I
R
P
E
D
V
K
-----------------
L
-------
S
K
D
V
I
K
------
D
D
S
W
I
L
V
G
K
G
K
V
K
---------------------------------------------------
11
PsiBlast_PDB
86.34
29%
-74
- C1 -
1OXV
7
?
A:
[4-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
V
K
N
V
S
K
V
F
KK
G
K
--
V
V
A
L
D
---
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
DDRLVAS
N
G
K
-----
L
I
---
V
-------
P
P
E
D
R
------
K
--
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
---------
T
A
F
E
N
I
A
F
-
P
L
T
N
------
M
K
-
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
-
D
I
H
H
V
L
N
-------
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
-
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
-
S
R
L
-
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
QVGK
P
E
D
L
Y
D
NPVS
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
--------
V
I
G
---
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
-----------------
L
-------
S
K
D
V
I
K
------
D
D
S
W
I
L
V
G
K
G
K
V
K
---------------------------------------------------
13
PsiBlast_PDB
84.59
29%
-72
- C1 -
1OXX
25
?
K:
[4-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
V
K
N
V
S
K
V
F
KK
G
K
--
V
V
A
L
D
---
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
DDRLVAS
N
G
K
-----
L
I
---
V
-------
P
P
E
D
R
------
K
--
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
---------
T
A
F
E
N
I
A
F
-
P
L
T
N
------
M
K
-
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
-
D
I
H
H
V
L
N
-------
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
-
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
-
S
R
L
-
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
QVGKPEDLYDNPVSIQVAS
L
I
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
--------
V
I
G
---
S
L
R
F
P
V
S
V
S
S
D
R
A
I
IG
I
R
P
E
D
V
K
-----------------
L
-------
S
K
D
V
I
K
------
D
D
S
W
I
L
V
G
K
G
K
V
K
---------------------------------------------------
3
PsiBlast_PDB
84.58
32%
-101
- C1 -
4WBS
1
?
A:
[40-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
V
R
N
L
K
K
R
Y
--
G
S
--
R
T
V
V
K
---
D
V
S
L
D
V
K
S
G
E
V
V
G
L
L
G
P
N
G
A
G
K
T
T
S
F
Y
M
I
V
G
L
V
P
L
D
A
G
E
I
D
L
-------
D
G
K
-----
S
I
---
S
LLP
I
H
--
K
R
A
S
L
------
G
--
L
S
Y
L
P
Q
E
A
S
V
F
R
K
L
---------
S
V
E
E
N
I
R
A
-
V
L
E
L
QVGDDG
K
R
-
L
S
K
D
A
I
A
S
R
T
E
A
L
L
D
E
L
-
Q
I
S
H
L
R
E
-------
N
P
A
L
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
T
N
P
S
F
I
L
L
D
E
P
F
A
G
V
D
-
P
I
A
V
L
E
I
Q
K
I
V
K
F
L
K
-
Q
-
R
-
N
I
G
V
L
I
T
D
H
N
V
R
E
T
L
G
I
C
D
H
A
Y
I
I
S
D
G
S
V
L
-------------------
A
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
83.34
35%
-93
* C1 *
1VPL
2
?
A:
[16-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
V
K
D
L
R
K
R
I
--
G
K
--
K
E
I
L
K
---
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
V
T
V
-------
F
G
K
-----
N
V
---
V
EE
P
----
H
E
V
R
K
------
L
--
I
S
Y
L
P
E
E
A
G
A
Y
R
N
M
---------
Q
G
I
E
Y
L
R
F
-
V
A
G
F
------
Y
A
-
S
S
S
S
E
I
E
E
M
V
E
R
A
T
E
I
A
-
G
L
G
E
K
I
K
-------
D
R
V
S
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
-
V
L
N
A
R
E
V
R
K
I
L
K
Q
A
S
-
Q
-
E
-
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
T
I
V
-------------------
E
T
G
T
V
E
E
L
K
E
R
Y
K
----------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.14
35%
-95
- C1 -
1VPL
2
?
A:
[15-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
V
V
K
D
L
R
K
R
I
--
G
K
--
K
E
I
L
K
---
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
V
T
V
-------
F
G
K
-----
N
V
VEE
P
-------
H
E
V
R
K
------
L
--
I
S
Y
L
P
E
E
A
G
A
Y
R
N
M
---------
Q
G
I
E
Y
L
R
F
-
V
A
G
F
------
Y
A
-
S
S
S
S
E
I
E
E
M
V
E
R
A
T
E
I
A
-
G
L
G
E
K
I
K
-------
D
R
V
S
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
-
V
L
N
A
R
E
V
R
K
I
L
K
Q
A
S
-
Q
-
E
-
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
T
I
V
-------------------
E
T
G
T
V
E
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
82.39
32%
-98
- C1 -
4WBS
1
?
B:
[40-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
V
R
N
L
K
K
R
Y
--
G
S
--
R
T
V
V
K
---
D
V
S
L
D
V
K
S
G
E
V
V
G
L
L
G
P
N
G
A
G
K
T
T
S
F
Y
M
I
V
G
L
V
P
L
D
A
G
E
I
D
L
-------
D
G
K
-----
S
I
---
S
LLP
I
H
--
K
R
A
S
L
------
G
--
L
S
Y
L
P
Q
E
A
S
V
F
R
K
L
---------
S
V
E
E
N
I
R
A
-
V
L
E
L
QVGG--
K
R
-
L
S
K
D
A
I
A
S
R
T
E
A
L
L
D
E
L
-
Q
I
S
H
L
R
E
-------
N
P
A
L
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
T
N
P
S
F
I
L
L
D
E
P
F
A
G
V
D
-
P
I
A
V
L
E
I
Q
K
I
V
K
F
L
K
-
Q
-
R
-
N
I
G
V
L
I
T
D
H
N
V
R
E
T
L
G
I
C
D
H
A
Y
I
I
S
D
G
S
V
L
-------------------
A
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
79.18
29%
-88
- C1 -
4QC2
2
?
A:
[4-219]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
K
N
L
A
K
A
Y
--
K
G
--
R
R
V
V
E
---
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
-------
D
D
D
DISLL
P
L
---
H
-------
A
R
A
R
R
------
G
--
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
---------
S
V
Y
D
N
L
M
A
-
V
L
Q
I
------
R
D
D
L
S
A
E
Q
R
E
D
R
A
N
E
L
M
E
E
F
-
H
I
E
H
L
R
D
-------
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
-
P
I
S
V
I
D
I
K
R
I
I
E
H
L
R
-
D
-
S
-
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
-------------------
A
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.17
33%
-88
- C1 -
4RVC
-
?
A:
[11-226]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
--
Y
T
A
Q
N
VLE
D
V
T
F
V
V
D
R
G
E
M
V
A
L
I
G
L
N
G
A
G
K
S
T
T
I
K
H
I
I
G
L
M
E
P
R
R
G
A
I
S
I
-------
N
G
Y
-----
R
L
ADG
P
-------
E
T
Y
R
R
------
Q
--
F
A
Y
I
P
E
T
P
V
L
Y
E
E
L
---------
T
L
E
E
H
L
R
L
-
A
A
M
A
------
Y
G
-
L
S
E
A
E
Y
E
R
R
L
P
P
L
L
R
E
F
-
R
L
E
R
R
L
S
-------
S
F
P
A
H
F
S
K
G
M
K
Q
K
V
M
I
V
C
A
F
L
L
E
P
P
L
Y
I
I
D
E
P
F
L
G
L
D
-
P
L
A
I
H
A
L
L
E
R
M
N
E
Q
K
-
A
-
K
-
G
A
G
I
L
L
S
T
H
I
L
A
T
A
E
R
Y
C
D
S
F
V
I
L
H
N
G
R
V
K
-------------------
A
K
G
T
L
D
D
I
R
R
Q
F
G
----------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
78.62
29%
-92
- C1 -
4P32
2
LPTB_ECOLI
A:
[3-218]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
K
N
L
A
K
A
Y
--
K
G
--
R
R
V
V
E
---
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
-------
D
D
D
DISLL
P
L
---
H
-------
A
R
A
R
R
------
G
--
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
---------
S
V
Y
D
N
L
M
A
-
V
L
Q
I
------
R
D
D
L
S
A
E
Q
R
E
D
R
A
N
E
L
M
E
E
F
-
H
I
E
H
L
R
D
-------
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
-
P
I
S
V
I
D
I
K
R
I
I
E
H
L
R
-
D
-
S
-
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
-------------------
A
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
77.43
33%
-79
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[4-218]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
H
I
G
H
L
S
K
S
F
--
Q
N
--
T
P
V
L
N
---
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
-------
S
G
K
-----
T
I
---
F
-------
S
K
N
T
N
LPVRER
R
--
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
---------
T
V
Y
R
N
I
A
Y
G
L
G
N
G
------
K
G
-
R
T
A
Q
E
-
R
Q
R
I
E
A
M
L
E
L
T
-
G
I
S
E
L
A
G
-------
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
-
A
-
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
77.01
25%
-65
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
PFK
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
LKPLLDDGFGKTDRSVLLW
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
MPVAFFDKQS
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
FYYS
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
KEVLIFGG
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
FPSVMDSLT
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
SEQEK
D
E
G
K
RVIDRAT
G
D
L
E
F
R
N
V
T
F
T
Y
PG
R
E
--
V
P
A
L
R
---
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
-------
D
G
H
-----
D
L
---
R
EYT
L
---
A
S
L
R
N
------
Q
--
V
A
L
V
S
Q
N
V
H
L
F
N
D
----------
T
V
A
N
N
I
A
Y
--
A
R
T
------
E
E
-
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
-
F
I
N
K
M
D
N
GLD
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
-
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
-
N
-
R
T
S
L
V
I
A
-
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
-------------------
E
R
G
T
--------------------------------------------
H
S
E
L
L
A
-----------------
Q
H
---------------------------
G
V
Y
A
Q
L
H
K
M
Q
F
G
-------------------------------------------
18
PsiBlast_PDB
76.56
33%
-80
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-223]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
H
I
G
H
L
S
K
S
F
--
Q
N
--
T
P
V
L
N
---
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
-------
S
G
K
-----
T
I
---
F
-------
S
K
N
T
N
L
P
VRER
R
--
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
---------
T
V
Y
R
N
I
A
Y
G
L
G
N
G
------
K
G
-
R
T
A
Q
E
-
R
Q
R
I
E
A
M
L
E
L
T
-
G
I
S
E
L
A
G
-------
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
-
A
-
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
76.46
30%
-82
- C1 -
1OXX
21
?
K:
[3-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
I
V
K
N
V
S
K
V
F
--
K
K
GK
V
V
A
L
D
---
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
-------
D
D
R
-----
L
V
---
A
SNGKLIV
P
P
E
D
R
------
K
--
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
---------
T
A
F
E
N
I
A
F
-
P
L
T
N
------
M
K
-
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
-
D
I
H
H
V
L
N
-------
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
-
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
-
L
-
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
-------------------
Q
V
G
K
P
E
D
L
Y
D
N
P
V
----------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
76.36
28%
-92
- C1 -
4P33
7
LPTB_ECOLI
A:
[3-218]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
K
N
L
A
K
A
Y
--
K
G
--
R
R
V
V
E
---
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
-------
D
D
D
DISLL
P
L
---
H
-------
A
R
A
R
R
------
G
--
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
---------
S
V
Y
D
N
L
M
A
-
V
L
Q
I
------
R
D
D
L
S
A
E
Q
R
E
D
R
A
N
E
L
M
E
E
F
-
H
I
E
H
L
R
D
-------
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
Q
P
F
A
G
V
D
-
P
I
S
V
I
D
I
K
R
I
I
E
H
L
R
-
D
-
S
-
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
-------------------
A
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
75.08
27%
-61
- C1 -
1OXS
23
?
C:
[1-352]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
V
R
I
I
V
K
N
V
S
K
V
F
KK
G
K
--
V
V
A
L
D
---
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
-------
D
D
R
-----
L
V
---
A
-------
S
N
--
G
------
K
--
L
I
V
P
P
E
D
R
K
I
G
M
V
F
QTWALYPNL
T
A
F
E
N
I
A
F
-
P
L
T
N
------
M
K
-
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
-
D
I
H
H
V
L
N
-------
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
-
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
-
S
-
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
-------------------
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
ASLIGEIN
E
L
E
---
G
K
V
T
N
E
G
V
V
I
G
S
L
R
--
F
P
V
S
V
S
S
-----------------
D
R
A
I
I
G
I
R
P
E
D
V
K
L
SKDVIK
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
-
G
L
F
R
I
T
I
T
P
L
D
S
E
E
E
IFTYSDHPIHSGEEVLVYVRKDKIKVFEK
48
Fugue
74.58
23%
-65
- C1 -
1Z47
1
?
A:
[11-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GS
M
T
I
E
F
V
G
V
E
K
I
Y
P-
G
G
--
A
R
S
V
R
---
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
-------
G
G
K
-----
R
V
---
T
-------
D
L
P
P
Q
------
K
RN
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
---------
T
V
Y
D
N
V
S
F
-
G
L
R
E
------
K
R
-
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
-
R
L
E
S
Y
A
N
-------
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
-
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
-
D
-
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
-------------------
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
--------
A
S
F
IGE
S
N
V
W
T
R
A
V
Q
N
G
R
I
E
--
V
A
G
A
A
L
P
V
DPAVSEG
S
E
V
A
V
V
V
R
P
K
D
V
E
L
Q
P
A
S
E
R
E
A
H
------
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
K
D
G
E
V
W
E
V
H
V
P
S
A
D
R
H
RWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R---------
38
HHSearch
74.48
28%
-95
- C1 -
1JI0
1
?
A:
[6-231]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
E
V
Q
S
L
H
V
Y
Y
--
G
A
--
I
H
A
I
K
---
G
I
D
L
K
V
P
R
G
Q
I
V
T
L
I
G
A
N
G
A
G
K
T
T
T
L
S
A
I
A
G
L
V
R
A
Q
K
G
K
I
I
F
-------
N
G
Q
-----
D
I
---
T
NKP
A
H
--
V
I
N
R
M
------
G
--
I
A
L
V
P
E
G
R
R
I
F
P
E
L
---------
T
V
Y
E
N
L
M
M
-
G
A
Y
N
------
R
K
-
D
K
-
E
G
I
K
R
D
L
E
W
I
F
S
L
F
P
R
L
K
E
R
L
K
-------
Q
L
G
G
T
L
S
G
G
E
Q
Q
M
L
A
I
G
R
A
L
M
S
R
P
K
L
L
M
M
D
E
P
S
L
G
L
A
-
P
I
L
V
S
E
V
F
E
V
I
Q
K
I
N
-
Q
-
E
-
G
T
T
I
L
L
V
E
Q
N
A
L
G
A
L
K
V
A
H
Y
G
Y
V
L
E
T
G
Q
I
V
-------------------
L
E
G
K
A
S
E
L
L
D
N
E
M
----------------------------------------------------------------------------------------------------------------------------------------------