@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2214: (2016-04-02 )
MNYTQQLKQKDSEYVWHPFTQMGVYSKEEAIIIEKGKGSYLYDTNGNKYLDGYASLWVNVHGHNNKYLNKVIKKQLNKIAHSTLLGSSNIPSIELAEKLIEITPSNLRKVFYSDTGSASVEIAIKMAYQYWKNIDREKYAKKNKFITLNHGYHGDTIGAVSVGGIKTFHKIFKDLIFENIQVESPSFYRSNYDTENEIMTAILTNIEQILIERNDEIAGFILEPLIQGATGLFVHPKGFLKEVEKLCKKYDVLLICDEVAVGFGRTGKMFACNHEDVQPDIMCLGKAITGGYLPLAATLTSQKIYNTFLSDSHGVNTFFHGHTYTGNQIVCTVALENIRLYEKRKLLSHIETTSSTLEKQLHALKRHRNVGDVRGRGLMFGVELVTDKDSKTPLEIEKVERIVRKCKENGLMIRNLENVITFVPVLSMSNKEVKTMVRIFKKAVHNILDRKC
Atome Classification :
(63 SA)
...-......10........20........30........40.---.......50......-..60........70.......--.80.........90........100.......110.......120.......130----.......140.---......150.......160----....-...170........180...-...------.190-.-......200.......210-.......220...-....230.......240.......250.......260.......270..--.....280.......290.......300.......310.......320.......330.......340.......350........360-.......--370.......380..--.....390...--....--400......----.410....-------...420.......430.......440.......450
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
Y
-
T
Q
Q
L
K
QKDSEYVWHP
F
T
QMGVYSKE
E
A
I
I
I
EKGKG
S
Y
L
Y
---DTNGN
K
Y
L
D
G
Y
A
S
L
W
-
V
N
V
HGH
N
N
K
Y
L
N
K
V
I
K
K
Q
L
N
K
--
I
A
-
H
S
T
LLGSSNIP
S
I
E
L
A
E
K
L
I
EI
T
P
S
N
L
R
K
V
FYSDTGS
A
S
V
E
I
A
I
K
M
A
Y
Q
Y
W
K
----NI
D
R
E
K
Y
AKKN---
K
F
I
T
LNHGYHGD
T
I
G
A
V
SV----G
G
I
K
-
T
F
H
K
I
-
F
K
D
L
I
F
E
NIQVESP-
S
F
Y------RSNY-D-
T
E
N
E
I
M
T
A
I
L
T
N
I
E
Q
I
L
I
E-RND
E
I
A
G
F
I
L
E
P
L
-IQGA
T
G
L
F
VH
P
K
G
F
L
K
E
V
E
K
L
C
K
KY
D
V
L
L
I
C
D
E
V
A
VGFGRTG
K
M
F
A
CNH--EDVQ
P
D
I
M
C
L
G
K
A
ITGGY
L
P
L
A
A
T
L
T
S
Q
K
I
Y
N
T
F
LSDSHGV
N
T
F
FH
G
H
T
YTG
N
Q
I
V
C
T
V
A
LE
N
I
R
L
Y
E
K
R
K
L
L
S
H
I
-
E
T
T
S
S
T
L
E
K
Q
L
H
-
A
L
K
RHRN--VGDVRGR
G
L
M
F
G
V
E
L
--
V
TDKDSKTPL
E
--
I
E
K
V
--
E
R
I
V
R
K
C
K
E----N
G
L
M
I
R
N
L
-------
E
N
V
I
T
F
VPVLSMS
N
K
E
V
K
T
M
V
R
I
F
K
K
A
V
H
N
I
LDRKC
21
PsiBlast_CBE
94.47
48%
-96
- C1 -
3DOD
2
BIOK_BACSU
B:
[4-443]
------
D
L
I
E
K
S
K
K
H
L
W
L
P
F
T
Q
M
K
D
Y
D
-
E
N
P
L
I
I
E
S
G
T
G
I
K
V
K
---
D
I
N
G
K
E
Y
Y
D
G
F
S
S
V
W
-
L
N
V
H
G
H
R
K
K
E
L
D
D
A
I
K
K
Q
L
G
K
--
I
A
-
H
S
T
L
L
G
M
T
N
V
P
A
T
Q
L
A
E
T
L
I
D
I
S
P
K
K
L
T
R
V
F
Y
S
D
S
G
A
E
A
M
E
I
A
L
K
M
A
F
Q
Y
W
K
----
N
I
G
K
---
P
E
K
Q
---
K
F
I
A
M
K
-----------------------------------
S
Y
K
A
P
I
P
-
Y
V
Y
------
R
S
E
S
-
G
-
D
P
D
E
C
R
D
Q
C
L
R
E
L
A
Q
L
L
E
E
-
H
H
E
E
I
A
A
L
S
I
E
S
M
-
V
Q
G
A
S
G
M
I
V
M
P
E
G
Y
L
A
G
V
R
E
L
C
T
T
Y
D
V
L
M
I
V
D
E
V
A
T
G
F
G
R
T
G
K
M
F
A
C
E
H
--
E
N
V
Q
P
D
L
M
A
A
G
K
G
I
T
G
G
Y
L
P
I
A
V
T
F
A
T
E
D
I
Y
K
A
F
Y
D
D
Y
E
N
L
K
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
S
E
N
I
V
E
Q
V
-
A
E
K
S
K
K
L
H
F
L
L
Q
-
D
L
H
A
L
P
H
--
V
G
D
I
R
Q
L
G
F
M
C
G
A
E
L
--
V
R
S
K
E
T
K
E
P
Y
P
--
A
D
R
R
I
G
Y
K
V
S
L
K
M
R
E
----
L
G
M
L
T
R
P
L
-------
G
D
V
I
A
F
L
P
P
L
A
S
T
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
V
-----
87
HHSearch
94.02
48%
-99
- C1 -
3DOD
2
BIOK_BACSU
A:
[3-445]
-----
H
D
L
I
E
K
S
K
K
H
L
W
L
P
F
T
Q
M
K
D
Y
D
-
E
N
P
L
I
I
E
S
G
T
G
I
K
V
K
---
D
I
N
G
K
E
Y
Y
D
G
F
S
S
V
W
-
L
N
V
H
G
H
R
K
K
E
L
D
D
A
I
K
K
Q
L
G
K
--
I
A
-
H
S
T
L
L
G
M
T
N
V
P
A
T
Q
L
A
E
T
L
I
D
I
S
P
K
K
L
T
R
V
F
Y
S
D
S
G
A
E
A
M
E
I
A
L
K
M
A
F
Q
Y
W
K
----
N
I
---
G
K
P
E
K
Q
---
K
F
I
A
M
K
-----------------------------------
S
Y
K
A
P
I
P
-
Y
V
Y
------
R
S
E
S
-
G
-
D
P
D
E
C
R
D
Q
C
L
R
E
L
A
Q
L
L
E
E
-
H
H
E
E
I
A
A
L
S
I
-
E
S
M
V
Q
G
A
S
G
M
I
V
M
P
E
G
Y
L
A
G
V
R
E
L
C
T
T
Y
D
V
L
M
I
V
D
E
V
A
T
G
F
G
R
T
G
K
M
F
A
C
E
H
--
E
N
V
Q
P
D
L
M
A
A
G
K
G
I
T
G
G
Y
L
P
I
A
V
T
F
A
T
E
D
I
Y
K
A
F
Y
D
D
Y
E
N
L
K
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
S
E
N
I
V
E
Q
V
-
A
E
K
S
K
K
L
H
F
L
L
Q
D
L
H
A
-
L
P
H
--
V
G
D
I
R
Q
L
G
F
M
C
G
A
E
L
--
V
R
S
K
E
T
K
E
P
Y
P
AD
R
R
I
G
--
Y
K
V
S
L
K
M
R
E
----
L
G
M
L
T
R
P
L
-------
G
D
V
I
A
F
L
P
P
L
A
S
T
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
V
T
S
---
1
PsiBlast_PDB
93.16
48%
-95
- C1 -
3DOD
2
BIOK_BACSU
A:
[3-443]
-----
H
D
L
I
E
K
S
K
K
H
L
W
L
P
F
T
Q
M
K
D
Y
D
-
E
N
P
L
I
I
E
S
G
T
G
I
K
V
K
---
D
I
N
G
K
E
Y
Y
D
G
F
S
S
V
W
-
L
N
V
H
G
H
R
K
K
E
L
D
D
A
I
K
K
Q
L
G
K
--
I
A
-
H
S
T
L
L
G
M
T
N
V
P
A
T
Q
L
A
E
T
L
I
D
I
S
P
K
K
L
T
R
V
F
Y
S
D
S
G
A
E
A
M
E
I
A
L
K
M
A
F
Q
Y
W
K
----
N
I
G
K
---
P
E
K
Q
---
K
F
I
A
M
K
-----------------------------------
S
Y
K
A
P
I
P
-
Y
V
Y
------
R
S
E
S
-
G
-
D
P
D
E
C
R
D
Q
C
L
R
E
L
A
Q
L
L
E
E
-
H
H
E
E
I
A
A
L
S
I
E
S
M
-
V
Q
G
A
S
G
M
I
V
M
P
E
G
Y
L
A
G
V
R
E
L
C
T
T
Y
D
V
L
M
I
V
D
E
V
A
T
G
F
G
R
T
G
K
M
F
A
C
E
H
--
E
N
V
Q
P
D
L
M
A
A
G
K
G
I
T
G
G
Y
L
P
I
A
V
T
F
A
T
E
D
I
Y
K
A
F
Y
D
D
Y
E
N
L
K
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
S
E
N
I
V
E
Q
V
-
A
E
K
S
K
K
L
H
F
L
L
Q
-
D
L
H
A
L
P
H
--
V
G
D
I
R
Q
L
G
F
M
C
G
A
E
L
--
V
R
S
K
E
T
K
E
P
Y
P
--
A
D
R
R
I
G
Y
K
V
S
L
K
M
R
E
----
L
G
M
L
T
R
P
L
-------
G
D
V
I
A
F
L
P
P
L
A
S
T
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
V
-----
2
PsiBlast_PDB
93.12
48%
-93
- C1 -
3DRD
-
BIOK_BACSU
A:
[2-443]
----
T
H
D
L
I
E
K
S
K
K
H
L
W
L
P
F
T
Q
M
K
D
Y
D
-
E
N
P
L
I
I
E
S
G
T
G
I
K
V
K
---
D
I
N
G
K
E
Y
Y
D
G
F
S
S
V
W
-
L
N
V
H
G
H
R
K
K
E
L
D
D
A
I
K
K
Q
L
G
K
--
I
A
-
H
S
T
L
L
G
M
T
N
V
P
A
T
Q
L
A
E
T
L
I
D
I
S
P
K
K
L
T
R
V
F
Y
S
D
S
G
A
E
A
M
E
I
A
L
K
M
A
F
Q
Y
W
K
----
N
I
G
K
---
P
E
K
Q
---
K
F
I
A
M
K
-----------------------------------
S
Y
K
A
P
I
P
-
Y
V
Y
------
R
S
E
S
-
G
-
D
P
D
E
C
R
D
Q
C
L
R
E
L
A
Q
L
L
E
E
-
H
H
E
E
I
A
A
L
S
I
E
S
M
-
V
Q
G
A
S
G
M
I
V
M
P
E
G
Y
L
A
G
V
R
E
L
C
T
T
Y
D
V
L
M
I
V
D
E
V
A
T
G
F
G
R
T
G
K
M
F
A
C
E
H
--
E
N
V
Q
P
D
L
M
A
A
G
K
G
I
T
G
G
Y
L
P
I
A
V
T
F
A
T
E
D
I
Y
K
A
F
Y
D
D
Y
E
N
L
K
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
S
E
N
I
V
E
Q
V
-
A
E
K
S
K
K
L
H
F
L
L
Q
-
D
L
H
A
L
P
H
--
V
G
D
I
R
Q
L
G
F
M
C
G
A
E
L
--
V
R
S
K
E
T
K
E
P
Y
P
--
A
D
R
R
I
G
Y
K
V
S
L
K
M
R
E
----
L
G
M
L
T
R
P
L
-------
G
D
V
I
A
F
L
P
P
L
A
S
T
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
V
-----
93
HHSearch
79.01
34%
-87
- C1 -
3N5M
6
?
A:
[9-451]
----
T
D
E
L
L
A
K
D
E
Q
Y
V
W
H
G
M
R
P
F
S
P
---
N
S
T
T
V
G
A
K
A
E
G
C
W
V
E
---
D
I
Q
G
K
R
Y
L
D
G
M
S
G
L
W
-
C
V
N
S
G
Y
G
R
K
E
L
A
E
A
A
Y
K
Q
L
Q
T
--
L
S
-
Y
F
P
-
M
S
Q
S
H
E
P
A
I
K
L
A
E
K
L
N
E
W
L
G
G
-
E
Y
V
I
F
F
S
N
S
G
S
E
A
N
E
T
A
F
K
I
A
R
Q
Y
Y
A
----
Q
K
--
G
-
E
P
H
R
Y
---
K
F
M
S
R
Y
R
G
Y
H
G
N
T
M
A
T
M
A
A
----
T
G
Q
A
-
Q
R
R
Y
Q
-
Y
E
P
F
A
S
G
F
L
H
V
T
P
P
-
D
C
Y
------
R
M
P
G
I
E
-
R
E
N
I
Y
D
V
E
C
V
K
E
V
D
R
V
M
T
W
E
L
S
E
T
I
A
A
F
I
M
-
E
P
-
I
I
T
G
G
G
I
L
M
A
P
Q
D
Y
M
K
A
V
H
E
T
C
Q
K
H
G
A
L
L
I
S
D
E
V
I
C
G
F
G
R
T
G
K
A
F
G
F
M
N
--
Y
D
V
K
P
D
I
I
T
M
A
K
G
I
T
S
A
Y
L
P
L
S
A
T
A
V
K
R
E
I
Y
E
A
F
K
G
K
G
-
E
Y
E
F
F
R
H
I
N
T
F
G
G
N
P
A
A
C
A
L
A
L
K
N
L
E
I
I
E
N
E
N
L
I
E
R
S
-
A
Q
M
G
S
L
L
L
E
Q
L
K
E
E
I
G
E
H
P
L
--
V
G
D
I
R
G
K
G
L
L
V
G
I
E
L
--
V
N
D
K
E
T
K
E
P
I
D
--
N
D
K
I
--
A
S
V
V
N
A
C
K
E
----
K
G
L
I
I
G
R
N
GMTTAGY
N
N
I
L
T
L
A
P
P
L
V
I
S
S
E
E
I
A
F
V
I
G
T
L
K
T
A
M
E
R
------
62
PsiBlast_CBE
75.76
31%
-86
- C1 -
4AH3
2
?
B:
[7-446]
----
T
S
Q
W
R
E
L
D
A
A
H
H
L
H
P
F
T
D
T
A
S
L
N
Q
A
G
A
R
V
M
T
R
G
E
G
V
Y
L
W
---
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
-
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
--
L
P
F
Y
N
T
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
-------
D
V
Q
G
K
P
E
K
K
---
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
----
G
G
M
K
-
Y
M
H
E
Q
-
G
D
L
P
I
P
G
M
A
H
I
E
Q
P
-
W
W
Y
------
K
H
G
K
-
D
M
T
P
D
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
--
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
H
--
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
A
G
----
G
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
--
V
K
N
K
-
A
K
R
E
L
---
F
P
D
F
--
G
E
I
G
T
L
C
R
D
IFFR
N
N
L
I
M
R
A
C
-------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
--------
59
PsiBlast_CBE
75.54
31%
-89
- C1 -
4BA4
1
?
B:
[33-446]
------------------------------
A
R
V
M
T
R
G
E
G
V
Y
L
W
---
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
-
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
--
L
P
F
Y
N
T
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
-------
D
V
Q
G
K
P
E
K
K
---
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
----
G
G
M
K
-
Y
M
H
E
Q
-
G
D
L
P
I
P
G
M
A
H
I
E
Q
P
-
W
W
Y
------
K
H
G
K
-
D
M
T
P
D
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
--
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
H
--
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
A
G
----
G
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
--
V
K
N
K
-
A
K
R
E
L
---
F
P
D
F
--
G
E
I
G
T
L
C
R
D
IFFR
N
N
L
I
M
R
A
C
-------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
--------
60
PsiBlast_CBE
75.30
31%
-86
- C1 -
4AH3
2
?
D:
[7-446]
----
T
S
Q
W
R
E
L
D
A
A
H
H
L
H
P
F
T
D
T
A
S
L
N
Q
A
G
A
R
V
M
T
R
G
E
G
V
Y
L
W
---
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
-
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
--
L
P
F
Y
N
T
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
-------
D
V
Q
G
K
P
E
K
K
---
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
----
G
G
M
K
-
Y
M
H
E
Q
-
G
D
L
P
I
P
G
M
A
H
I
E
Q
P
-
W
W
Y
------
K
H
G
K
-
D
M
T
P
D
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
--
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
H
--
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
A
G
----
G
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
--
V
K
N
K
-
A
K
R
E
L
---
F
P
D
F
--
G
E
I
G
T
L
C
R
D
IFFR
N
N
L
I
M
R
A
C
-------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
--------
61
PsiBlast_CBE
75.19
31%
-83
- C1 -
4AH3
2
?
C:
[7-446]
----
T
S
Q
W
R
E
L
D
A
A
H
H
L
H
P
F
T
D
T
A
S
L
N
Q
A
G
A
R
V
M
T
R
G
E
G
V
Y
L
W
---
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
-
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
--
L
P
F
Y
N
T
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
-------
D
V
Q
G
K
P
E
K
K
---
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
----
G
G
M
K
-
Y
M
H
E
Q
-
G
D
L
P
I
P
G
M
A
H
I
E
Q
P
-
W
W
Y
------
K
H
G
K
-
D
M
T
P
D
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
--
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
H
--
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
A
G
----
G
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
--
V
K
N
K
-
A
K
R
E
L
---
F
P
D
F
--
G
E
I
G
T
L
C
R
D
IFFR
N
N
L
I
M
R
A
C
-------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
--------
67
PsiBlast_CBE
74.91
31%
-82
- C1 -
4A6T
2
?
D:
[7-446]
----
T
S
Q
W
R
E
L
D
A
A
H
H
L
H
P
F
T
D
T
A
S
L
N
Q
A
G
A
R
V
M
T
R
G
E
G
V
Y
L
W
---
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
-
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
--
L
P
F
Y
N
T
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
-------
D
V
Q
G
K
P
E
K
K
---
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
----
G
G
M
K
-
Y
M
H
E
Q
-
G
D
L
P
I
P
G
M
A
H
I
E
Q
P
-
W
W
Y
------
K
H
G
K
-
D
M
T
P
D
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
--
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
H
--
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
A
G
----
G
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
--
V
K
N
K
-
A
K
R
E
L
---
F
P
D
F
--
G
E
I
G
T
L
C
R
D
IFFR
N
N
L
I
M
R
A
C
-------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
--------
109
Fugue
74.84
33%
-93
- C1 -
1DTY
5
BIOA_ECOLI
A:
[1-429]
---M
T
T
D
D
L
A
F
D
E
R
H
I
W
H
P
Y
T
S
M
T
--
S
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
---
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
-
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
-
S
Q
I
D
A
M-
S
-
H
V
M
F
G
E
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
D
A
K
GE-----------ARD
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
----
C
D
P
D
-
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
-
Q
S
R
MDGEWD---------
E
R
D
M
V
G
F
A
R
L
M
A
A
H
R
H
-----
E
I
A
A
V
I
I
E
P
I
-
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
AE--
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
D
G
E
A
G
--
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
-
A
D
I
E
V
Q
L
R
E
Q
L
A
-
P
A
R
D
-
A
-EM
V
A
D
V
R
V
L
G
A
I
G
V
V
E
T
--
T
-----
H
P
V
N
------
M
--
A
A
L
Q
K
F
F
V
E
----
Q
G
V
W
I
R
P
F
-------
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
Q
24
PsiBlast_CBE
74.84
32%
-88
- C1 -
1MLZ
4
BIOA_ECOLI
B:
[9-423]
-----------
D
Q
R
H
I
L
H
P
Y
T
S
M
--
T
S
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
---
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
-
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
-
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
--------
A
K
G
E
A
R
Q
---
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
----
C
D
P
D
N
S
M
H
S
L
-
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
R
M
------
D
G
E
W
-
D
-
E
R
D
------
M
V
G
F
A
R
L
M
A
A
-
H
R
H
E
I
A
A
V
I
I
E
P
I
-
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
--
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
E
A
G
C
--
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
-
A
D
I
E
V
Q
L
R
E
Q
L
A
-
P
A
R
D
A
E
M
--
V
A
D
V
R
V
L
G
A
I
G
V
V
E
--------
T
T
H
P
V
N
--
M
A
A
L
--
Q
K
F
F
---
V
E
----
Q
G
V
W
I
R
P
F
-------
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
------
68
PsiBlast_CBE
74.72
31%
-84
- C1 -
4A6T
2
?
C:
[7-446]
----
T
S
Q
W
R
E
L
D
A
A
H
H
L
H
P
F
T
D
T
A
S
L
N
Q
A
G
A
R
V
M
T
R
G
E
G
V
Y
L
W
---
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
-
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
--
L
P
F
Y
N
T
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
-------
D
V
Q
G
K
P
E
K
K
---
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
----
G
G
M
K
-
Y
M
H
E
Q
-
G
D
L
P
I
P
G
M
A
H
I
E
Q
P
-
W
W
Y
------
K
H
G
K
-
D
M
T
P
D
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
--
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
H
--
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
A
G
----
G
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
--
V
K
N
K
-
A
K
R
E
L
---
F
P
D
F
--
G
E
I
G
T
L
C
R
D
IFFR
N
N
L
I
M
R
A
C
-------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
--------
58
PsiBlast_CBE
74.52
31%
-88
- C1 -
4BA5
1
?
A:
[33-446]
------------------------------
A
R
V
M
T
R
G
E
G
V
Y
L
W
---
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
-
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
--
L
P
F
Y
N
T
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
-------
D
V
Q
G
K
P
E
K
K
---
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
----
G
G
M
K
-
Y
M
H
E
Q
-
G
D
L
P
I
P
G
M
A
H
I
E
Q
P
-
W
W
Y
------
K
H
G
K
-
D
M
T
P
D
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
--
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
H
--
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
A
G
----
G
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
--
V
K
N
K
-
A
K
R
E
L
---
F
P
D
F
--
G
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
-------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
--------
4
PsiBlast_PDB
74.50
32%
-85
- C1 -
1MGV
5
BIOA_ECOLI
A:
[9-423]
-----------
D
Q
R
H
I
L
H
P
Y
T
S
M
--
T
S
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
---
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
-
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
-
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
--------
A
K
G
E
A
R
Q
---
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
----
C
D
P
D
N
S
M
H
S
L
-
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
R
M
------
D
G
E
W
-
D
-
E
R
D
------
M
V
G
F
A
R
L
M
A
A
-
H
R
H
E
I
A
A
V
I
I
E
P
I
-
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
--
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
E
A
G
C
--
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
-
A
D
I
E
V
Q
L
R
E
Q
L
A
-
P
A
R
D
A
E
M
--
V
A
D
V
R
V
L
G
A
I
G
V
V
E
--------
T
T
H
P
V
N
--
M
A
A
L
--
Q
K
F
F
---
V
E
----
Q
G
V
W
I
A
P
F
-------
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
------
70
PsiBlast_CBE
74.27
31%
-83
- C1 -
4A6T
2
?
A:
[7-446]
----
T
S
Q
W
R
E
L
D
A
A
H
H
L
H
P
F
T
D
T
A
S
L
N
Q
A
G
A
R
V
M
T
R
G
E
G
V
Y
L
W
---
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
-
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
--
L
P
F
Y
N
T
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
-------
D
V
Q
G
K
P
E
K
K
---
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
----
G
G
M
K
-
Y
M
H
E
Q
-
G
D
L
P
I
P
G
M
A
H
I
E
Q
P
-
W
W
Y
------
K
H
G
K
-
D
M
T
P
D
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
--
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
H
--
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
A
G
----
G
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
--
V
K
N
K
-
A
K
R
E
L
---
F
P
D
F
--
G
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
-------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
--------
23
PsiBlast_CBE
74.17
32%
-88
- C1 -
1QJ5
3
BIOA_ECOLI
B:
[9-423]
-----------
D
Q
R
H
I
L
H
P
Y
T
S
M
--
T
S
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
---
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
-
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
-
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
--------
A
K
G
E
A
R
Q
---
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
----
C
D
P
D
N
S
M
H
S
L
-
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
R
M
------
D
G
E
W
-
D
-
E
R
D
------
M
V
G
F
A
R
L
M
A
A
-
H
R
H
E
I
A
A
V
I
I
E
P
I
-
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
--
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
E
A
G
C
--
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
-
A
D
I
E
V
Q
L
R
E
Q
L
A
-
P
A
R
D
A
E
M
--
V
A
D
V
R
V
L
G
A
I
G
V
V
E
--------
T
T
H
P
V
N
--
M
A
A
L
--
Q
K
F
F
---
V
E
----
Q
G
V
W
I
R
P
F
-------
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
------
63
PsiBlast_CBE
73.81
31%
-82
- C1 -
4AH3
2
?
A:
[7-446]
----
T
S
Q
W
R
E
L
D
A
A
H
H
L
H
P
F
T
D
T
A
S
L
N
Q
A
G
A
R
V
M
T
R
G
E
G
V
Y
L
W
---
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
-
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
--
L
P
F
Y
N
T
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
-------
D
V
Q
G
K
P
E
K
K
---
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
----
G
G
M
K
-
Y
M
H
E
Q
-
G
D
L
P
I
P
G
M
A
H
I
E
Q
P
-
W
W
Y
------
K
H
G
K
-
D
M
T
P
D
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
--
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
H
--
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
A
G
----
G
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
--
V
K
N
K
-
A
K
R
E
L
---
F
P
D
F
--
G
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
-------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
--------
69
PsiBlast_CBE
73.80
31%
-83
- C1 -
4A6T
2
?
B:
[7-446]
----
T
S
Q
W
R
E
L
D
A
A
H
H
L
H
P
F
T
D
T
A
S
L
N
Q
A
G
A
R
V
M
T
R
G
E
G
V
Y
L
W
---
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
-
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
--
L
P
F
Y
N
T
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
-------
D
V
Q
G
K
P
E
K
K
---
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
----
G
G
M
K
-
Y
M
H
E
Q
-
G
D
L
P
I
P
G
M
A
H
I
E
Q
P
-
W
W
Y
------
K
H
G
K
-
D
M
T
P
D
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
--
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
H
--
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
A
G
----
G
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
--
V
K
N
K
-
A
K
R
E
L
---
F
P
D
F
--
G
E
I
G
T
L
C
R
D
IFFR
N
N
L
I
M
R
A
C
-------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
--------
25
PsiBlast_CBE
73.75
32%
-87
- C1 -
1MLY
4
BIOA_ECOLI
B:
[9-423]
-----------
D
Q
R
H
I
L
H
P
Y
T
S
M
--
T
S
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
---
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
-
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
-
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
--------
A
K
G
E
A
R
Q
---
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
----
C
D
P
D
N
S
M
H
S
L
-
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
R
M
------
D
G
E
W
-
D
-
E
R
D
------
M
V
G
F
A
R
L
M
A
A
-
H
R
H
E
I
A
A
V
I
I
E
P
I
-
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
--
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
E
A
G
C
--
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
-
A
D
I
E
V
Q
L
R
E
Q
L
A
-
P
A
R
D
A
E
M
--
V
A
D
V
R
V
L
G
A
I
G
V
V
E
--------
T
T
H
P
V
N
--
M
A
A
L
--
Q
K
F
F
---
V
E
----
Q
G
V
W
I
R
P
F
-------
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
------
27
PsiBlast_CBE
72.62
32%
-85
- C1 -
1MGV
7
BIOA_ECOLI
B:
[9-423]
-----------
D
Q
R
H
I
L
H
P
Y
T
S
M
--
T
S
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
---
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
-
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
-
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
--------
A
K
G
E
A
R
Q
---
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
----
C
D
P
D
N
S
M
H
S
L
-
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
R
M
------
D
G
E
W
-
D
-
E
R
D
------
M
V
G
F
A
R
L
M
A
A
-
H
R
H
E
I
A
A
V
I
I
E
P
I
-
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
--
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
E
A
G
C
--
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
-
A
D
I
E
V
Q
L
R
E
Q
L
A
-
P
A
R
D
A
E
M
--
V
A
D
V
R
V
L
G
A
I
G
V
V
E
--------
T
T
H
P
V
N
--
M
A
A
L
--
Q
K
F
F
---
V
E
----
Q
G
V
W
I
A
P
F
-------
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
------
5
PsiBlast_PDB
72.31
32%
-86
- C1 -
1S07
4
BIOA_ECOLI
A:
[9-423]
-----------
D
Q
R
H
I
L
H
P
Y
T
S
M
--
T
S
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
---
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
-
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
-
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
--------
A
K
G
E
A
R
Q
---
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
----
C
D
P
D
N
S
M
H
S
L
-
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
R
M
------
D
G
E
W
-
D
-
E
R
D
------
M
V
G
F
A
R
L
M
A
A
-
H
R
H
E
I
A
A
V
I
I
E
P
I
-
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
A
T
G
K
L
F
A
C
E
H
--
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
E
A
G
C
--
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
-
A
D
I
E
V
Q
L
R
E
Q
L
A
-
P
A
R
D
A
E
M
--
V
A
D
V
R
V
L
G
A
I
G
V
V
E
--------
T
T
H
P
V
N
--
M
A
A
L
--
Q
K
F
F
---
V
E
----
Q
G
V
W
I
R
P
F
-------
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
------
26
PsiBlast_CBE
71.59
32%
-85
- C1 -
1S07
4
BIOA_ECOLI
B:
[9-423]
-----------
D
Q
R
H
I
L
H
P
Y
T
S
M
--
T
S
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
---
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
-
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
-
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
--------
A
K
G
E
A
R
Q
---
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
----
C
D
P
D
N
S
M
H
S
L
-
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
R
M
------
D
G
E
W
-
D
-
E
R
D
------
M
V
G
F
A
R
L
M
A
A
-
H
R
H
E
I
A
A
V
I
I
E
P
I
-
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
A
T
G
K
L
F
A
C
E
H
--
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
E
A
G
C
--
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
-
A
D
I
E
V
Q
L
R
E
Q
L
A
-
P
A
R
D
A
E
M
--
V
A
D
V
R
V
L
G
A
I
G
V
V
E
--------
T
T
H
P
V
N
--
M
A
A
L
--
Q
K
F
F
---
V
E
----
Q
G
V
W
I
R
P
F
-------
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
------
71
PsiBlast_CBE
71.57
31%
-85
- C1 -
4A6R
2
?
B:
[34-446]
-------------------------------
R
V
M
T
R
G
E
G
V
Y
L
W
---
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
-
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
--
L
P
F
Y
N
T
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
-------
D
V
Q
G
K
P
E
K
K
---
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
----
G
G
M
K
-
Y
M
H
-----
L
P
I
P
G
M
A
H
I
E
Q
P
-
W
W
Y
------
K
H
G
K
-
D
M
T
P
D
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
--
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
H
--
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
A
G
----
G
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
--
V
K
N
K
-
A
K
R
E
L
---
F
P
D
F
--
G
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
-------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
--------
72
PsiBlast_CBE
71.55
31%
-85
- C1 -
4A6R
2
?
A:
[34-446]
-------------------------------
R
V
M
T
R
G
E
G
V
Y
L
W
---
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
-
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
--
L
P
F
Y
N
T
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
-------
D
V
Q
G
K
P
E
K
K
---
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
----
G
G
M
K
-
Y
M
H
----
D
L
P
I
P
G
M
A
H
I
E
Q
P
-
W
W
Y
------
K
H
G
K
-
D
M
T
P
D
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
--
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
H
--
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
A
G
----
G
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
--
V
K
N
K
-
A
K
R
E
L
---
F
P
D
F
--
G
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
-------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
--------
22
PsiBlast_CBE
70.42
32%
-84
- C1 -
1DTY
5
BIOA_ECOLI
B:
[9-423]
-----------
D
E
R
H
I
W
H
P
Y
T
S
M
--
T
S
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
---
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
-
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
-
H
V
M
F
G
E
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
D
----
A
----
K
G
E
A
R
D
---
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
----
C
D
P
D
N
S
M
H
S
L
-
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
R
M
------
D
G
E
W
-
D
-
E
R
D
------
M
V
G
F
A
R
L
M
A
A
-
H
R
H
E
I
A
A
V
I
I
E
P
I
-
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
--
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
-
I
S
D
G
E
A
-
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
-
A
D
I
E
V
Q
L
R
E
Q
L
A
-
P
A
R
D
A
E
M
--
V
A
D
V
R
V
L
G
A
I
G
V
V
E
--------
T
T
H
P
V
N
--
M
A
A
L
--
Q
K
F
F
---
V
E
----
Q
G
V
W
I
R
P
F
-------
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
------
3
PsiBlast_PDB
69.81
32%
-82
- C1 -
1DTY
5
BIOA_ECOLI
A:
[9-423]
-----------
D
E
R
H
I
W
H
P
Y
T
S
M
--
T
S
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
---
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
-
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
-
H
V
M
F
G
E
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
D
----
A
----
K
G
E
A
R
D
---
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
----
C
D
P
D
N
S
M
H
S
L
-
W
K
G
Y
L
P
E
N
L
F
A
P
A
P
Q
S
R
M
------
D
G
E
W
-
D
-
E
R
D
------
M
V
G
F
A
R
L
M
A
A
-
H
R
H
E
I
A
A
V
I
I
E
P
I
-
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
--
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
-
I
S
D
G
E
A
-
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
-
A
D
I
E
V
Q
L
R
E
Q
L
A
-
P
A
R
D
A
E
M
--
V
A
D
V
R
V
L
G
A
I
G
V
V
E
--------
T
T
H
P
V
N
--
M
A
A
L
--
Q
K
F
F
---
V
E
----
Q
G
V
W
I
R
P
F
-------
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
------
49
PsiBlast_CBE
68.90
32%
-84
- C1 -
4CXR
5
BIOA_MYCTU
B:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
14
PsiBlast_PDB
68.76
32%
-85
- C1 -
4CXR
6
BIOA_MYCTU
A:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
---
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
33
PsiBlast_CBE
68.48
32%
-86
- C1 -
4W1W
8
BIOA_MYCTU
B:
[4-412]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
LIR
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
6
PsiBlast_PDB
68.05
32%
-85
- C1 -
4W1V
5
BIOA_MYCTU
A:
[5-413]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
---
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
36
PsiBlast_CBE
67.95
32%
-83
- C1 -
4WYF
3
?
B:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
LIR
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
40
PsiBlast_CBE
67.93
32%
-84
- C1 -
4WYC
8
?
B:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
37
PsiBlast_CBE
67.93
32%
-83
- C1 -
4WYE
7
?
B:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
52
PsiBlast_CBE
67.76
32%
-84
- C1 -
3TFT
3
BIOA_MYCTU
B:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
---
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
8
PsiBlast_PDB
67.57
32%
-86
- C1 -
3TFT
3
BIOA_MYCTU
A:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-----
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
45
PsiBlast_CBE
67.35
32%
-86
- C1 -
4W1X
5
BIOA_MYCTU
B:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
47
PsiBlast_CBE
67.23
32%
-83
- C1 -
4MQQ
4
BIOA_MYCTU
B:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
50
PsiBlast_CBE
67.20
32%
-82
- C1 -
4CXQ
7
BIOA_MYCTU
B:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
--
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
38
PsiBlast_CBE
67.20
32%
-82
- C1 -
4WYD
10
?
B:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
13
PsiBlast_PDB
67.03
32%
-81
- C1 -
4CXQ
8
BIOA_MYCTU
A:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
-
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
32
PsiBlast_CBE
66.99
32%
-83
- C1 -
4W1V
9
BIOA_MYCTU
B:
[5-413]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
10
PsiBlast_PDB
66.95
32%
-84
- C1 -
4MQP
4
BIOA_MYCTU
A:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
35
PsiBlast_CBE
66.90
32%
-83
- C1 -
4WYG
14
?
B:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
LIR
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
11
PsiBlast_PDB
66.70
32%
-83
- C1 -
4MQQ
7
BIOA_MYCTU
A:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
48
PsiBlast_CBE
66.60
32%
-84
- C1 -
4MQP
4
BIOA_MYCTU
B:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
LIR
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
54
PsiBlast_CBE
66.16
31%
-85
- C1 -
3BV0
2
BIOA_MYCTU
A:
[11-419]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
----------
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
----------
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
15
PsiBlast_PDB
66.13
32%
-84
- C1 -
4W1X
7
BIOA_MYCTU
A:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
12
PsiBlast_PDB
65.88
32%
-85
- C1 -
4MQR
4
BIOA_MYCTU
A:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
46
PsiBlast_CBE
65.73
32%
-86
- C1 -
4MQR
4
BIOA_MYCTU
B:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
19
PsiBlast_PDB
65.56
32%
-80
- C1 -
4WYG
10
?
A:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
16
PsiBlast_PDB
65.54
32%
-81
- C1 -
4WYC
7
?
A:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
34
PsiBlast_CBE
65.53
32%
-83
- C1 -
4XEW
4
?
B:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
LIR
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
7
PsiBlast_PDB
65.51
32%
-82
- C1 -
4W1W
9
BIOA_MYCTU
A:
[4-412]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
39
PsiBlast_CBE
65.43
32%
-81
- C1 -
4WYD
13
?
A:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
17
PsiBlast_PDB
65.26
32%
-83
- C1 -
4WYE
7
?
A:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
56
PsiBlast_CBE
65.08
31%
-83
- C1 -
3LV2
3
BIOA_MYCTU
A:
[36-444]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
---------
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
----
L
M
R
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
9
PsiBlast_PDB
65.07
32%
-82
- C1 -
3TFU
3
BIOA_MYCTU
A:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH---------------
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
55
PsiBlast_CBE
64.84
31%
-85
- C1 -
3LV2
3
BIOA_MYCTU
B:
[36-444]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
----------
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
-----------
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
R
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
53
PsiBlast_CBE
64.56
31%
-81
- C1 -
3BV0
2
BIOA_MYCTU
B:
[11-419]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
----------
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
----------
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
51
PsiBlast_CBE
64.51
32%
-84
- C1 -
3TFU
3
BIOA_MYCTU
B:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
------
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH---------------
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
18
PsiBlast_PDB
64.27
32%
-83
- C1 -
4WYF
3
?
A:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------
20
PsiBlast_PDB
63.33
32%
-81
- C1 -
4XEW
4
?
A:
[31-439]
-----
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-
R
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
-
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
----
G
---
R
G
L
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
CDPH
G
G
M
----
H
S
L
-
W
T
D
V
L
--
A
A
Q
V
F
A
P
-
Q
V
P
------
R
-
D
Y
-
D
-
P
------
A
Y
S
A
A
F
E
A
Q
L
A
Q
-
H
A
G
E
L
A
A
V
V
V
E
P
V
-
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
D
-
T
A
R
A
L
P
A
--
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
DR
P
V
D
L
A
V
A
T
P
A
A
--
L
D
R
-----------------
G
V
W
L
R
P
F
-------
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
-------------------