@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2216: (2016-04-02 )
MFQITFKILNWIRPYKARMILGFSMSFLNAIFIALPIFLAAKIFNNVLSHKPIYMKDILNVVIIMVLLVIGRFITAYFKSKSHESIAYEMSAKERLDIGDKLKNVRLGYFNSHHSNELTTIVTTDLTFLENFAMKMVDIVVNGYILITVLILSLLVVSWQVSLLACIGVLLSFFAIQLLERKSRQNAPAYHNVQNQLVEKVLEVIRGIQVIKSFAKENTSLKSFNQAVNESKRINTKIEMQYIPFNLLHLLSLKVVSIMIVLVACLLYMNHSIDLPTLIMISIFSFVIFDSVENINSAAHVLEMIDMTIDDIEKIKNAPELDENGKNLTIKNENIAFQNVNFSYDDKQVIKNVNFEIPTQTSTAIIGPSGSGKSTLCHLLLRFYDIDDGNIRIDGVDIKDMTLSTLMSKISAVFQKVYLFNDTIENNILFGNPGATKEEIIRAAKQACCHDFIMSLPEGYQTMLNEKGSNLSGGEKQRISIARAILKDAPIIILDEATASIDPENEQLIQTAINELSKGKTVITIAHKLETIKNADQIIVLNEGEIIQKGSHDELIRKPGMYQDFIRIKSKSAGWKL
Atome Classification :
(62 SA)
------------------------------------------------------------------------.........10--.......-.-------20........30.....---...40........50-----...-.....60........70----.----.......80........90........100.......110.......120....-...130...-....140.........150.....---..160.......170......------.180--.........190...-....200.-......210.......220.......230........240....--.....250.....----..260.......270........-------280......-----.290.....-..300.---......310----...-....-320.-----..---.-------.------..330...-----...-..340..--.---.---.---.---.--350.......360.......370.......380.....---..390.......400.........410...--....420.......430-...---.-....440.......450.......460.......470.......480.......490.......500...----....510.....--.--.520...--....530..-.....540.......550......--.-560.......570.....-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------M
F
Q
I
T
F
K
I
L
N
W
--
I
R
P
Y
K
A
R
-
M
-------
I
L
G
F
S
M
S
F
L
N
A
I
F
I
A
L
P
---
I
F
L
A
A
K
I
F
N
N
V
LSHK-----P
I
Y
-
M
K
D
I
L
N
V
V
I
I
M
V
L
L
V
I
G
----
R
----
F
I
T
A
Y
F
KSKSHE
S
I
A
Y
EMSA
K
E
RLD
I
G
D
KLKN
V
R
L
G
Y
FNSHHSN
E
L
T
T
I
V
T
T
D
L
-
T
F
L
E
N
F
A
M
K
-
M
V
D
I
V
--VN
G
Y
I
L
I
T
V
L
I
L
S
L
L
V
V
---
S
W
Q
V
S
L
L
A
C
I
G
V
L
L
S
F
F
A
I
Q
L
------
L
E
----
R
K
SRQNAP
A
Y
H
N
V
Q
N
-
Q
L
V
E
K
V
L
E
-
V
I
R
G
I
Q
V
I
K
S
F
A
KENT
S
L
K
S
F
N
Q
A
VNES-KRIN
T
K
I
E
M
--
Q
YI
P
--
F
N
L
L
H
L
L
S
L
K
V
V
S
----
I
M
I
V
L
V
A
C
L
L
YMNH-SID
L
P
T
L
I
-------
M
I
S
I
F
S
F
V
I
-----
F
D
S
V
E
N
I
N
S
-
A
A
H
V
L
E
---
M
I
D
M
T
I
D
D
I
----
E
K
I-KNAP-ELDE-----NG---
K
-------
N
------
L
T
I
K-NE
N
-----
I
A
F
-
Q
NVNFSY--
D
---
D
---
K
---
Q
---
V
--
I
K
NV
N
F
E
IPTQT
S
T
A
I
IGPSGS
G
K
S
T
L
C
H
L
L
L
R
F
YDID---DG
N
I
R
I
D
G
V
DI
K
D
--
M
T
L
S
T
L
M
S
K
I
S
A
V
F
Q
--
K
V
Y
LFNDTIEN
N
I
L
FG--NPG---A-
T
K
E
E
I
I
R
A
A
K
Q
A
C
C
H
D
F
I
M
SL
P
E
G
Y
Q
T
M
L
N
EKGSNLSGG
E
K
Q
R
I
S
I
A
R
A
I
LKDA
P
I
I
I
LDEATASIDP
E
N
----
E
Q
L
I
Q
T
A
I
N
E
LS--K--G
K
T
V
I
T
I
--
A
H
K
L
E
T
IKN-A
D
Q
I
I
V
LNE
G
E
IIQKGS
H
D
E
L
IRK--P-G
M
Y
Q
D
F
I
R
IKSKSAGWKL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
90.81
32%
-120
- C1 -
4Q4A
1
Y288_THEMA
B:
[27-586]
------------------------------------------------------------------------------
R
L
L
G
Y
--
L
R
P
H
T
F
T
-
L
-------
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
---
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
RFDL
L
P
R
Y
-
M
L
-
I
L
G
T
I
Y
A
L
T
S
L
L
F
--------------
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
-
D
N
I
N
N
V
L
G
N
-
S
I
I
Q
F
--
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
---
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
------
V
S
----
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
-
Q
L
N
G
I
I
E
E
-
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
-
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
----
G
F
G
G
W
L
A
L
K
--------
D
I
I
T
V
G
-------
T
I
A
T
F
I
G
Y
S
-----
R
Q
F
T
R
P
L
N
E
-
L
S
N
Q
F
N
---
M
I
Q
M
A
L
A
S
A
----
E
R
I
-
F
E
I
L
-
D
L
E
E
-----
E
K
---
D
-------
D
PDAVEL
R
E
V
R
-
G
E
------
I
E
F
-
K
N
V
W
F
S
Y
--
D
---
K
---
K
---
K
P--
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
--
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
--
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
--
N
P
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
----
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
I
I
--
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
-
G
F
Y
Y
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
89.59
32%
-117
- C1 -
4Q4H
-
Y288_THEMA
B:
[27-586]
------------------------------------------------------------------------------
R
L
L
G
Y
--
L
R
P
H
T
F
T
-
L
-------
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
---
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
RFDL
L
P
R
Y
-
M
L
-
I
L
G
T
I
Y
A
L
T
S
L
L
F
--------------
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
-
D
N
I
N
N
V
L
G
N
-
S
I
I
Q
F
--
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
---
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
------
V
S
----
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
-
Q
L
N
G
I
I
E
E
-
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
-
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
----
G
F
G
G
W
L
A
L
K
--------
D
I
I
T
V
G
-------
T
I
A
T
F
I
G
Y
S
-----
R
Q
F
T
R
P
L
N
E
-
L
S
N
Q
F
N
---
M
I
Q
M
A
L
A
S
A
----
E
R
I
-
F
E
I
L
-
D
L
E
E
-----
E
K
---
D
-------
D
PDAVEL
R
E
V
R
-
G
E
------
I
E
F
-
K
N
V
W
F
S
Y
--
D
---
K
---
K
---
K
P--
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
--
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
--
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
--
N
P
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
----
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
I
I
--
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
-
G
F
Y
Y
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.39
32%
-119
- C1 -
3QF4
1
Y288_THEMA
B:
[27-586]
------------------------------------------------------------------------------
R
L
L
G
Y
--
L
R
P
H
T
F
T
-
L
-------
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
---
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
RFDL
L
P
R
Y
-
M
L
-
I
L
G
T
I
Y
A
L
T
S
L
L
F
--------------
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
-
D
N
I
N
N
V
L
G
N
-
S
I
I
Q
F
--
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
---
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
------
V
S
----
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
-
Q
L
N
G
I
I
E
E
-
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
-
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
----
G
F
G
G
W
L
A
L
K
--------
D
I
I
T
V
G
-------
T
I
A
T
F
I
G
Y
S
-----
R
Q
F
T
R
P
L
N
E
-
L
S
N
Q
F
N
---
M
I
Q
M
A
L
A
S
A
----
E
R
I
-
F
E
I
L
-
D
L
E
E
-----
E
K
---
D
-------
D
PDAVEL
R
E
V
R
-
G
E
------
I
E
F
-
K
N
V
W
F
S
Y
--
D
---
K
---
K
---
K
P--
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
--
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
--
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
--
N
P
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
----
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
I
I
--
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
-
G
F
Y
Y
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.76
32%
-119
- C1 -
4Q4J
-
Y288_THEMA
B:
[27-586]
------------------------------------------------------------------------------
R
L
L
G
Y
--
L
R
P
H
T
F
T
-
L
-------
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
---
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
RFDL
L
P
R
Y
-
M
L
-
I
L
G
T
I
Y
A
L
T
S
L
L
F
--------------
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
-
D
N
I
N
N
V
L
G
N
-
S
I
I
Q
F
--
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
---
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
------
V
S
----
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
-
Q
L
N
G
I
I
E
E
-
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
-
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
----
G
F
G
G
W
L
A
L
K
--------
D
I
I
T
V
G
-------
T
I
A
T
F
I
G
Y
S
-----
R
Q
F
T
R
P
L
N
E
-
L
S
N
Q
F
N
---
M
I
Q
M
A
L
A
S
A
----
E
R
I
-
F
E
I
L
-
D
L
E
E
EKDDP
D
A
---
V
-------
E
------
L
R
E
V
-
R
G
E
-----
I
E
F
-
K
N
V
W
F
S
Y
--
D
---
K
---
K
---
K
P--
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
--
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
--
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
--
N
P
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
----
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
I
I
--
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
-
G
F
Y
Y
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
85.18
30%
-108
- C1 -
2ONJ
4
Y1866_STAAM
A:
[4-577]
------------------------------------------------------------------------------
R
Y
L
Q
F
--
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
---
I
--
D
G
V
I
N
N
H
A
L
T
T
D
-----
E
K
V
-
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
----
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
----
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
-
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
--
L
D
---
C
I
T
I
I
I
A
L
S
I
M
F
---
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
----
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
-
F
L
H
E
R
V
-----
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
---
K
N
-
T
N
F
L
T
R
-
A
L
--
K
H
T
R
--
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
-
S
I
T
V
G
T
L
A
-------
A
F
V
G
Y
L
E
L
L
-----
F
G
P
L
R
R
L
V
A
-
S
F
T
T
L
T
---
Q
S
F
A
S
M
D
R
V
----
F
Q
L
-
I
D
E
D
-
Y
D
I
K
-----
N
G
VGA
Q
-------
P
------
I
E
I
K
-
Q
G
R
-----
I
D
I
-
D
H
V
S
F
Q
Y
--
N
---
D
---
N
---
E
AP-
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
--
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
--
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
--
R
P
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
----
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
I
V
--
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
84.35
30%
-108
- C1 -
2HYD
3
Y1866_STAAM
A:
[4-577]
------------------------------------------------------------------------------
R
Y
L
Q
F
--
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
---
I
--
D
G
V
I
N
N
H
A
L
T
T
D
-----
E
K
V
-
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
----
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
----
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
-
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
--
L
D
---
C
I
T
I
I
I
A
L
S
I
M
F
---
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
----
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
-
F
L
H
E
R
V
-----
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
---
K
N
-
T
N
F
L
T
R
-
A
L
--
K
H
T
R
--
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
-
S
I
T
V
G
T
L
A
-------
A
F
V
G
Y
L
E
L
L
-----
F
G
P
L
R
R
L
V
A
-
S
F
T
T
L
T
---
Q
S
F
A
S
M
D
R
V
----
F
Q
L
-
I
D
E
D
-
Y
D
I
K
-----
N
G
VGA
Q
-------
P
------
I
E
I
K
-
Q
G
R
-----
I
D
I
-
D
H
V
S
F
Q
Y
--
N
---
D
---
N
---
E
AP-
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
--
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
--
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
--
R
P
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
----
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
I
V
--
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
HHSearch
81.28
26%
-107
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[6-572]
---------------------------------------------------------------------------
E
A
R
K
L
L
G
L
--
A
Y
P
E
R
R
R
-
L
-------
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
---
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
-----
T
V
D
Y
S
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
----
G
----
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
-
A
L
L
G
R
S
V
T
E
-
N
L
S
D
G
--
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
---
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
------
Y
G
----
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
-
Q
A
T
Q
L
A
E
E
-
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
-
M
Q
L
A
R
K
E
A
F
--
A
R
A
G
--
F
F
G
A
T
G
L
S
G
N
L
I
V
----
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
-
H
M
T
V
G
E
L
S
-------
S
F
L
M
Y
A
F
W
V
-----
G
I
S
I
G
G
L
S
S
-
F
Y
S
E
L
M
---
K
G
L
G
A
G
G
R
L
----
W
E
L
-
L
E
R
E
-
P
K
L
P
-----
F
N
---
E
G
V
I
L
---
N
------
E
K
S
F
-
Q
G
A
-----
L
E
F
-
K
N
V
H
F
A
Y
--
P
---
A
RPE
V
---
P
---
I
--
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
--
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
--
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
--
A
D
D
PSS
V
-
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
----
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
--
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
HHSearch
80.39
27%
-91
- C1 -
3B60
2
MSBA_SALTY
A:
[13-581]
----------------------------------------------------------------------------
F
R
R
L
W
P
T
--
I
A
P
F
K
A
G
-
L
-------
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
---
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
-----
D
R
--
S
-
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
----
R
----
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
-
E
Q
V
A
S
S
S
S
G
-
A
L
I
T
V
--
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
---
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
------
V
S
----
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
-
Q
V
T
T
S
A
E
Q
-
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
-
R
L
Q
G
M
K
M
V
S
--
A
S
S
I
--
S
D
P
I
I
Q
L
I
A
S
L
A
L
----
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
-
S
L
T
A
G
T
I
T
-------
V
V
F
S
S
M
I
A
L
-----
M
R
P
L
K
S
L
T
N
-
V
N
A
Q
F
Q
---
R
G
M
A
A
C
Q
T
L
----
F
A
I
-
L
D
S
E
-
Q
E
K
D
-----
E
G
---
K
R------
V
------
I
D
R
A
-
T
G
D
-----
L
E
F
-
R
N
V
T
F
T
Y
--
P
---
G
---
R
EV-
P
---
A
--
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
--
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
--
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
--
R
T
E
E--
Y
-
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
----
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
S
L
V
I
--
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
-
G
V
Y
A
Q
L
H
K
M
Q
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Fugue
79.85
27%
-89
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
-------------------------------------------------------------------------
W
Q
T
F
R
R
L
W
P
T
--
I
A
P
F
K
A
G
-
L
-------
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
---
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
-----
D
---
R
S
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
----
R
----
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
-
E
Q
V
A
S
S
S
S
G
-
A
L
I
T
V
--
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
---
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
------
V
S
----
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
-
Q
V
T
T
S
A
E
Q
-
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
-
R
L
Q
G
M
K
M
V
S
--
A
S
S
I
--
S
D
P
I
I
Q
L
I
A
S
L
A
L
----
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
-
S
L
T
A
G
T
I
T
-------
V
V
F
S
S
M
I
A
L
-----
M
R
P
L
K
S
L
T
N
-
V
N
A
Q
F
Q
---
R
G
M
A
A
C
Q
T
L
----
F
A
I
-
L
D
S
E
Q
E
K
D
E
-----
G
K
---
R
-------
V
------
I
D
R
A
-
T
G
D
-----
L
E
F
-
R
N
V
T
F
T
Y
PG
R
---
E
---
V
---
P
---
A
--
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
--
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
--
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
--
R
T
E
---
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
----
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
S
L
V
I
--
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
-
G
V
Y
A
Q
L
H
K
M
Q
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
79.27
29%
-105
- C1 -
4F4C
-
PGP1_CAEEL
A:
[128-704]
---------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
D
F
-
E
H
D
V
M
N
V
V
W
S
Y
A
A
M
T
V
G
----
M
----
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
Q
E
I
S
W
F
D
T
N
H
S
G
T
L
A
T
K
L
F
D
N
L
----
E
R
V
K
E
G
-
T
G
D
K
I
--
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
T
L
-----
V
M
L
A
V
T
P
I
Q
A
------
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
-
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
N
G
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
-
K
K
A
G
V
-
L
K
G
--
L
F
L
G
--
I
S
F
G
A
M
Q
A
S
N
F
I
S
----
F
A
L
A
F
Y
I
G
V
G
W
V
-
H
-
D
G
S
L
N
F
G
D
-------
M
L
T
T
F
S
S
V
M
-----
M
G
S
M
A
-
L
G
L
-
A
G
P
Q
L
A
---
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
L
-
D
R
K
P
-
V
I
D
S
-----
S
S
---
K
A
G
R
K---
D
------
M
K
I
K
-
G
D
------
I
T
V
-
E
N
V
H
F
T
Y
--
P
SRP
D
---
V
---
P
---
I
--
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
---
K
G
K
I
T
I
D
G
V
D
V
R
D
--
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
--
E
P
A
L
F
N
C
T
I
E
E
N
I
S
L
G
--
K
E
G
---
I
-
T
R
E
E
M
V
A
A
C
K
M
A
N
A
E
K
F
I
K
T
L
P
N
G
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
----
E
G
I
V
Q
Q
A
L
D
K
A
A
--
K
--
G
R
T
T
I
I
I
--
A
H
R
L
S
T
I
R
N
-
A
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
A
Q
--
Q
-
G
L
Y
Y
D
L
V
T
A
Q
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
HHSearch
78.13
25%
-107
- C1 -
3WMG
6
?
A:
[14-598]
----------------------------------------------------------------------------
A
R
R
I
F
A
L
--
A
W
S
S
S
A
T
M
I
-------
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
---
A
I
V
F
G
R
M
F
Q
V
F
T
K
S
K
-----
S
Q
I
-
E
G
E
T
W
K
Y
S
V
G
F
V
G
I
G
V
F
----
E
----
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
-
Q
V
I
Q
Y
S
F
S
K
-
L
-
G
A
V
--
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
---
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
A
V
V
V
------
Q
M
----
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
-
S
A
G
S
V
A
A
E
-
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
-
Y
R
L
G
R
R
R
Y
I
--
S
D
G
L
--
F
F
G
L
S
M
L
V
I
F
C
V
Y
----
A
L
A
L
W
W
G
G
Q
L
I
A
R
G
-
S
L
N
L
G
N
L
L
-------
T
A
F
F
S
A
I
L
G
-----
F
M
G
V
G
Q
A
A
Q
-
V
W
P
D
V
T
---
R
G
L
G
A
G
G
E
L
----
F
A
M
-
I
D
R
V
-
P
Q
Y
R
-----
R
P
---
D
PG
A
E
V
V
T
Q
------
P
L
V
L
-
K
Q
G
-----
I
V
F
-
E
N
V
H
F
R
Y
--
P
---
T
RMN
V
---
E
---
V
--
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
--
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
--
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
G
--
K
R
D
---
A
-
T
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
----
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
D
--
G
V
T
S
V
V
I
--
A
H
R
L
S
T
V
A
R
-
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
GP
S
-
G
F
Y
Y
Q
L
V
E
K
Q
L
A
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Fugue
76.47
26%
-106
- C1 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
RYTT
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
--
G
L
P
L
M
S
I
-
L
-------
Q
G
K
V
S
Q
A
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
L
P
T
G
Q
N
Y
T
----
K
-----
T
D
F
-
E
H
D
V
M
N
V
V
W
S
Y
A
A
M
T
V
G
----
M
----
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
Q
E
I
S
W
F
D
T
N
H
S
G
T
L
A
T
K
L
F
D
N
L
-
E
R
V
K
E
G
T
G
D
-
K
I
G
M
A
--
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
---
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
------
I
A
----
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
-
K
A
G
K
V
V
E
E
-
T
I
S
S
I
R
T
V
V
S
L
N
G
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
-
K
K
A
-
G
V
L
K
G
--
L
F
L
G
--
I
S
F
G
A
M
Q
A
S
N
F
I
S
----
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
G
S
L
N
F
G
D
M
L
-------
T
T
F
S
S
V
M
M
G
-----
S
M
A
L
G
L
A
G
P
-
Q
L
A
V
L
G
---
T
A
Q
G
A
A
S
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----
Y
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V
L
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P
-
V
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-----
S
S
---
K
A
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R
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D
------
M
K
I
K
-
G
-
D
-----
I
T
V
-
E
N
V
H
F
T
Y
--
P
SRP
D
---
V
---
P
---
I
--
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
---
K
G
K
I
T
I
D
G
V
D
V
R
D
--
I
N
L
E
F
L
R
K
N
V
A
V
V
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--
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P
A
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L
G
--
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---
I
-
T
R
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M
V
A
A
C
K
M
A
N
A
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K
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I
K
T
L
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N
G
Y
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L
V
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R
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G
G
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K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
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----
E
G
I
V
Q
Q
A
L
D
K
A
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--
K
--
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R
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T
I
I
I
--
A
H
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L
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N
-
A
D
L
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K
N
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V
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V
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H
R
A
L
M
A
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--
Q
-
G
L
Y
Y
D
L
V
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A
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T
F
T
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D
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A
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GER
I
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K
D
A
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R
L
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ENNAQKTN
L
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Y
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RPH
A
L
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L
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M
S
T
A
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Y
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Y
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F
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N
V
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AGNPADFL
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
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I
C
S
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L
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F
M
G
I
A
S
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L
R
N
K
L
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R
N
V
L
S
QHIGFFDSPQNA
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
R
F
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V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
RRFTGKNVKSA
S
E
F
A
D
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I
A
I
E
A
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E
N
V
R
T
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E
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E
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E
A
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I
Q
G
L
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Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
TDPPTMQ
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
TLGFAT
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
KISKIDSLSLAGEKKKLYGK
V
I
F
K
N
V
R
F
A
Y
PERPEIEILK
G
L
S
F
S
V
E
PG
Q
T
L
A
L
V
G
P
S
GCGKST
V
V
A
L
L
E
RFYDTL
G
G
E
I
F
I
DGSEIKTLN
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
DCS
I
A
E
N
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YGLDPSSVT
M
A
Q
V
E
E
A
A
R
L
A
NI
H
N
F
I
A
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LPEGFETRVGDRGTQLS
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
NPK
I
L
L
L
D
EATSALDT
E
S
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K
V
V
Q
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A
L
D
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A
R
EG
R
T
C
I
V
I
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C
I
A
V
V
S
NGTII
E
K
G
T
H
T
Q
L
M
S
E
K
11
PsiBlast_PDB
76.11
29%
-95
- C1 -
3B60
2
MSBA_SALTY
A:
[12-572]
----------------------------------------------------------------------------
T
F
R
R
L
-
W
P
T
I
A
P
F
K
A
G
-
L
-------
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
---
L
S
L
L
K
P
L
L
D
D
G
-----------
F
-
G
K
T
D
R
S
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
----
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
-
L
I
T
V
V
--
R
E
G
A
S
I
I
G
L
F
I
M
-
M
F
Y
Y
---
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
------
V
S
----
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
-
Q
V
T
T
S
A
E
Q
-
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
--------
K
V
S
N
K
M
R
L
--
Q
G
M
K
--
M
V
S
A
S
S
I
S
D
P
I
I
Q
----
L
I
A
S
L
--
A
L
A
F
V
L
Y
-
A
A
S
F
P
S
V
M
DSLT
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
-
Q
F
Q
R
G
M
---
A
A
C
Q
T
L
F
A
I
------
L
-
D
S
E
Q
-
E
K
D
E
-----
G
K
---
R
-------
V
------
I
D
R
A
-
T
G
D
-----
L
E
F
-
R
N
V
T
F
T
Y
--
P
---
G
---
R
---
E
---
V
PA
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
--
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
--
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
--
R
T
E
---
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
----
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
S
L
V
I
--
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
-
G
V
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
71.81
35%
-102
- C1 -
4S0F
2
?
A:
[291-717]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
T
I
M
A
V
I
G
G
I
L
L
Y
I
Q
N
S
S
L
F
F
I
---
S
F
I
I
I
L
L
--
Y
G
I
I
V
T
V
F
----------------
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
-
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
-
M
K
S
S
F
K
E
G
M
--
L
Y
I
N
--
L
S
S
L
T
G
I
V
A
G
L
G
G
----
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
-
N
M
S
G
G
Q
L
L
-------
A
F
N
A
L
L
A
Y
F
-----
L
T
P
V
K
N
L
I
D
-
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
----
L
E
L
-
A
T
E
K
-
E
L
R
E
-----
D
S
---
D
-------
D
------
F
V
I
S
L
K
G
D
-----
I
E
F
-
R
N
V
D
F
R
Y
--
G
L--
R
---
K
---
P
---
V
--
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
--
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
--
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
--
N
E
N
---
V
-
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
----
E
N
H
I
K
D
A
I
Y
G
L
E
--
D
--
D
V
T
V
I
I
I
--
A
H
R
L
S
T
I
V
N
-
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
--
K
-
G
C
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
70.69
36%
-113
- C1 -
4RY2
-
?
A:
[291-717]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
T
I
M
A
V
I
G
G
I
L
L
Y
I
Q
N
S
S
L
F
F
I
---
S
F
I
I
I
L
L
--
Y
G
I
I
V
T
V
F
----------------
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
-
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
-
M
K
S
S
F
K
E
G
M
--
L
Y
I
N
--
L
S
S
L
T
G
I
V
A
G
L
G
G
----
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
-
N
M
S
G
G
Q
L
L
-------
A
F
N
A
L
L
A
Y
F
-----
L
T
P
V
K
N
L
I
D
-
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
----
L
E
L
-
A
T
E
K
-
E
L
---------------------------------
G
D
-----
I
E
F
-
R
N
V
D
F
R
Y
--
G
L--
R
---
K
---
P
---
V
--
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
--
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
--
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
--
N
E
N
---
V
-
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
----
E
N
H
I
K
D
A
I
Y
G
L
E
--
D
--
D
V
T
V
I
I
I
--
A
H
R
L
S
T
I
V
N
-
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
--
K
-
G
C
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
70.64
30%
-107
- C1 -
4A82
-
Y1866_STAAM
A:
[4-577]
------------------------------------------------------------------------------
R
Y
L
Q
F
--
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
---
I
--
D
G
V
I
N
N
H
A
L
T
T
D
-----
E
K
V
-
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
----
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
----
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
-
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
--
L
D
---
C
I
T
I
I
I
A
L
S
I
M
F
---
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
----
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
-
F
L
H
E
R
V
-----
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
---
K
N
-
T
N
F
L
T
R
-
A
L
--
K
H
T
R
--
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
-
S
I
T
V
G
T
L
A
-------
A
F
V
G
Y
L
E
L
L
-----
F
G
P
L
R
R
L
V
A
-
S
F
T
T
L
T
---
Q
S
F
A
S
M
D
R
V
----
F
Q
L
-
I
D
E
D
-
Y
D
I
K
-----
N
G
VGA
Q
-------
P
------
I
E
I
K
-
Q
G
R
-----
I
D
I
-
D
H
V
S
F
Q
Y
--
N
---
D
---
N
---
E
AP-
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
--
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
--
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
--
R
P
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
----
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
I
V
--
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
70.34
35%
-103
- C1 -
4AYX
5
ABCBA_HUMAN
A:
[201-574]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
Q
L
A
E
---
E
-
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
-
M
Q
L
A
R
K
E
A
F
--
A
R
A
G
--
F
F
G
A
T
G
L
S
G
N
L
I
V
----
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
-
H
M
T
V
G
E
L
S
-------
S
F
L
M
Y
A
F
W
V
-----
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
---
G
L
G
A
G
G
R
L
W
----
E
L
L
-
E
R
E
P
-
K
L
P
F
-----
N
------------
E
------
G
V
I
L
-
N
E
K
SFQG
A
L
E
F
-
K
N
V
H
F
A
Y
--
P
---
A
---
R
---
P
EVP
I
--
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
--
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
--
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
AD
D
P
S
---
S
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
----
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
--
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
--
P
N
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
70.27
35%
-101
- C1 -
4AYW
2
ABCBA_HUMAN
A:
[232-598]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
Q
L
A
E
---
E
-
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
-
M
Q
L
A
R
K
E
A
F
--
A
R
A
G
--
F
F
G
A
T
G
L
S
G
N
L
I
V
----
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
-
H
M
T
V
G
E
L
S
-------
S
F
L
M
Y
A
F
W
V
-----
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
---
G
L
G
A
G
G
R
L
W
----
E
L
L
-
E
R
E
P
-
K
L
P
F
-----
N
------------
E
------
G
V
I
L
-
N
E
K
SFQG
A
L
E
F
-
K
N
V
H
F
A
Y
--
P
---
A
---
R
---
P
EVP
I
--
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
--
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
--
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
AD
D
P
S
---
S
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
----
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
--
A
H
H
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
70.15
35%
-101
- C1 -
4S0F
2
?
B:
[291-717]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
T
I
MA
V
I
G
G
I
L
L
Y
I
Q
N
S
S
L
F
F
I
---
S
F
I
I
I
L
L
--
Y
G
I
I
V
T
V
F
----------------
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
-
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
-
M
K
S
S
F
K
E
G
M
--
L
Y
I
N
--
L
S
S
L
T
G
I
V
A
G
L
G
G
----
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
-
N
M
S
G
G
Q
L
L
-------
A
F
N
A
L
L
A
Y
F
-----
L
T
P
V
K
N
L
I
D
-
L
Q
P
L
I
Q
TAV
V
A
S
N
R
L
G
E
I
----
L
E
L
-
A
T
E
K
-
E
L
R
E
-----
D
S
---
D
-------
D
------
F
V
I
S
L
K
G
D
-----
I
E
F
-
R
N
V
D
F
R
Y
--
G
L--
R
---
K
---
P
---
V
--
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
--
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
--
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
--
N
E
N
---
V
-
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
----
E
N
H
I
K
D
A
I
Y
G
L
E
--
D
--
D
V
T
V
I
I
I
--
A
H
R
L
S
T
I
V
N
-
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
--
K
-
G
C
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
69.59
35%
-101
- C1 -
3ZDQ
4
ABCBA_HUMAN
A:
[201-572]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
Q
L
A
E
---
E
-
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
-
M
Q
L
A
R
K
E
A
F
--
A
R
A
G
--
F
F
G
A
T
G
L
S
G
N
L
I
V
----
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
-
H
M
T
V
G
E
L
S
-------
S
F
L
M
Y
A
F
W
V
-----
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
---
G
L
G
A
G
G
R
L
W
----
E
L
L
-
E
R
E
P
-
K
L
P
F
-----
N
------------
E
------
G
V
I
L
-
N
E
K
SFQG
A
L
E
F
-
K
N
V
H
F
A
Y
--
P
---
A
---
R
---
P
EVP
I
--
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
--
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
--
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
AD
D
P
S
---
S
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
----
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
--
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
--
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
68.40
35%
-98
- C1 -
4AYT
6
ABCBA_HUMAN
A:
[201-567]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
Q
L
A
E
---
E
-
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
-
M
Q
L
A
R
K
E
A
F
--
A
R
A
G
--
F
F
G
A
T
G
L
S
G
N
L
I
V
----
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
-
H
M
T
V
G
E
L
S
-------
S
F
L
M
Y
A
F
W
V
-----
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
---
G
L
G
A
G
G
R
L
W
----
E
L
L
-
E
R
E
P
-
K
L
P
F
-----
N
------------
E
------
G
V
I
L
-
N
E
K
SFQG
A
L
E
F
-
K
N
V
H
F
A
Y
--
P
---
A
---
R
---
P
EVP
I
--
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
--
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
--
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
AD
D
P
S
---
S
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
----
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
--
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
66.50
43%
-102
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[7-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
I
T
F
-
R
N
I
R
F
R
Y
KP
D
---
S
---
P
---
V
---
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
--
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
----
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
--
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
66.48
44%
-100
- C1 -
2FF7
1
A:
[7-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
I
T
F
-
R
N
I
R
F
R
Y
KP
D
---
S
---
P
---
V
---
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
--
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
--
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
HHSearch
66.23
43%
-100
* C1 *
2FF7
1
A:
[6-242]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
-----
I
T
F
-
R
N
I
R
F
R
Y
--
K
---
P
DS-
P
---
V
---
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
--
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
--
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
S
Y
L
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
65.94
43%
-99
- C1 -
2FGJ
2
D:
[7-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
I
T
F
-
R
N
I
R
F
R
Y
KP
D
---
S
---
P
---
V
---
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
--
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
--
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
65.84
43%
-102
- C1 -
2FGK
2
D:
[7-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
I
T
F
-
R
N
I
R
F
R
Y
KP
D
---
S
---
P
---
V
---
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
--
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
----
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
--
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
65.52
43%
-92
- C1 -
3NH9
3
A:
[28-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
F
D
L
L
K
E
E
T
----
E
-
V
-
K
D
L
P
----------
G
A
---
G
-------
P
------
L
R
F
Q
-
K
G
R
-----
I
E
F
-
E
N
V
H
F
S
Y
A-
D
---
G
---
R
---
E
---
T
--
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
--
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
--
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
--
R
V
T
---
A
-
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
----
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
T
I
V
V
--
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
-
G
V
Y
A
D
M
W
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
65.13
43%
-96
- C1 -
3NHB
3
A:
[28-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
F
D
L
L
K
E
E
T
----
E
-
V
-
K
D
L
P
----------
G
A
---
G
-------
P
------
L
R
F
Q
-
K
G
R
-----
I
E
F
-
E
N
V
H
F
S
Y
A-
D
-------
R
---
E
---
T
--
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
--
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
--
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
--
R
V
T
---
A
-
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
----
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
T
I
V
V
--
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
-
G
V
Y
A
D
M
W
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
65.10
43%
-100
- C1 -
1XEF
3
HLYBP_ECOLX
C:
[1-228]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
I
T
F
-
R
N
I
R
F
R
Y
KP
D
---
S
---
P
---
V
---
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
--
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
--
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
65.03
43%
-95
- C1 -
2FGJ
2
HLYBP_ECOLX
C:
[7-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
I
T
F
-
R
N
I
R
F
R
Y
KP
D
---
S
---
P
---
V
---
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
--
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
--
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
64.65
43%
-91
- C1 -
3NHA
4
A:
[28-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
F
D
L
L
K
E
E
T
----
E
-
V
-
K
D
L
P
----------
G
A
---
G
-------
P
------
L
R
F
Q
-
K
G
R
-----
I
E
F
-
E
N
V
H
F
S
Y
A-
D
-------
R
---
E
---
T
--
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
--
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
--
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
--
R
V
T
---
A
-
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
----
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
T
I
V
V
--
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
-
G
V
Y
A
D
M
W
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
64.62
43%
-97
- C1 -
1XEF
3
HLYBP_ECOLX
B:
[1-228]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
I
T
F
-
R
N
I
R
F
R
Y
KP
D
---
S
---
P
---
V
---
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
--
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
--
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
64.45
43%
-97
- C1 -
2PMK
1
A:
[1-230]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
D
-----
I
T
F
-
R
N
I
R
F
R
Y
KP
D
---
S
---
P
---
V
---
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
--
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
--
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
64.43
43%
-95
- C1 -
2FGJ
2
HLYBP_ECOLX
A:
[7-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
I
T
F
-
R
N
I
R
F
R
Y
KP
D
---
S
---
P
---
V
---
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
--
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
--
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
64.20
43%
-100
- C1 -
2FFA
2
A:
[7-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
I
T
F
-
R
N
I
R
F
R
Y
KP
D
---
S
---
P
---
V
---
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
--
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
--
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
64.10
43%
-97
- C1 -
1XEF
3
HLYBP_ECOLX
A:
[1-228]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
I
T
F
-
R
N
I
R
F
R
Y
KP
D
---
S
---
P
---
V
---
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
--
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
--
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
64.00
43%
-98
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[7-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
I
T
F
-
R
N
I
R
F
R
Y
KP
D
---
S
---
P
---
V
---
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
--
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
----
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
--
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
63.92
43%
-97
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[7-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
I
T
F
-
R
N
I
R
F
R
Y
KP
D
---
S
---
P
---
V
---
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
--
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
----
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
--
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
63.82
43%
-97
- C1 -
2FFB
1
A:
[7-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
I
T
F
-
R
N
I
R
F
R
Y
KP
D
---
S
---
P
---
V
---
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
--
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
----
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
--
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
63.32
43%
-95
- C1 -
1XEF
3
D:
[1-228]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
I
T
F
-
R
N
I
R
F
R
Y
KP
D
---
S
---
P
---
V
---
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
--
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
--
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
63.19
43%
-95
- C1 -
2FGJ
2
HLYBP_ECOLX
B:
[7-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
I
T
F
-
R
N
I
R
F
R
Y
KP
D
---
S
---
P
---
V
---
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
--
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
--
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
62.67
43%
-95
- C1 -
3B5J
1
A:
[1-230]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
D
-----
I
T
F
-
R
N
I
R
F
R
Y
KP
D
---
S
---
P
---
V
---
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
--
N
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
--
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
62.01
33%
-106
- C1 -
2IXE
3
D:
[17-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
-
Q
D
V
S
F
A
Y
--
P
---
N
---
H
PNV
Q
---
V
--
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
----
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L-
T
R
T
---
P
-
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
-----
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
----
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
--
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
R
S
M
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
61.97
33%
-94
- C1 -
2IXE
4
TAP1_RAT
A:
[17-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
-
Q
D
V
S
F
A
Y
--
P
---
N
---
H
PNV
Q
---
V
--
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L-
T
R
T
---
P
-
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
----
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
W
A
S
R
T
V
L
L
I
--
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
R
S
M
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
60.97
33%
-99
- C1 -
2IXF
4
TAP1_RAT
C:
[17-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
-
Q
D
V
S
F
A
Y
--
P
---
N
---
H
PNV
Q
---
V
--
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
-
T
R
T
---
P
-
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
----
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
W
A
S
R
T
V
L
L
I
--
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
R
S
M
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
60.87
33%
-102
- C1 -
2IXF
4
D:
[17-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
-
Q
D
V
S
F
A
Y
--
P
---
N
---
H
PNV
Q
---
V
--
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
----
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L-
T
R
T
---
P
-
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
----
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
--
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
R
S
M
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
60.79
32%
-101
- C1 -
4K8O
4
A:
[17-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
-
Q
D
V
S
F
A
Y
--
P
---
N
---
H
PNV
Q
---
V
--
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L-
T
R
T
---
P
-
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
A
A
G
N
----
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
--
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
R
S
M
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
60.60
32%
-97
- C1 -
1JJ7
2
A:
[15-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
F
-
Q
D
V
S
F
A
Y
--
P
---
N
---
R
---
P
DVL
V
--
L
Q
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
Q
L
L
L
D
G
K
P
L
P
Q
--
Y
E
H
R
Y
L
H
R
Q
V
A
A
V
G
Q
--
E
P
Q
V
F
G
R
S
L
Q
E
N
I
A
Y
G
L-
T
Q
K
---
P
-
T
M
E
E
I
T
A
A
A
V
K
S
G
A
H
S
F
I
S
G
L
P
Q
G
Y
D
T
E
V
D
E
A
G
S
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
C
V
L
I
L
D
D
A
T
S
A
L
D
A
N
S
Q
L
Q
V
E
Q
L
L
Y
E
S
P
E
R
Y
S
------
R
S
V
L
L
I
--
T
Q
H
L
S
L
V
E
Q
-
A
D
H
I
L
F
L
E
G
G
A
I
R
E
G
G
T
H
Q
Q
L
M
E
K
--
K
-
G
C
Y
W
A
M
V
Q
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
60.28
33%
-100
- C1 -
2IXF
5
TAP1_RAT
A:
[17-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
-
Q
D
V
S
F
A
Y
--
P
---
N
---
H
PNV
Q
---
V
--
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L-
T
R
T
---
P
-
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
----
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
--
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
R
S
M
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
59.88
32%
-96
- C1 -
2IXG
2
A:
[17-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
-
Q
D
V
S
F
A
Y
--
P
---
N
---
H
PNV
Q
---
V
--
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L-
T
R
T
---
P
-
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
A
V
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
----
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
--
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
R
S
M
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
59.37
33%
-100
- C1 -
2IXF
4
TAP1_RAT
B:
[17-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
-
Q
D
V
S
F
A
Y
--
P
---
N
---
H
PNV
Q
---
V
--
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L-
T
R
T
---
P
-
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
----
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
--
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
R
S
M
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
HHSearch
58.74
32%
-84
- C1 -
2IXE
4
TAP1_RAT
A:
[13-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
K
G
L
-----
V
K
F
-
Q
D
V
S
F
A
Y
--
P
---
N
HPN
V
---
Q
---
V
--
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
--
L
T
R
---
T
P
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
----
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
--
S
R
T
V
L
L
I
--
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
R
S
M
V
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
57.99
38%
-83
- C1 -
1MV5
2
LMRA_LACLA
B:
[2-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
-
R
H
V
D
F
A
Y
--
D
---
D
S--
E
---
Q
---
I
--
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
--
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
--
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
--
L
E
G
---
D
Y
T
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
----
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
--
A
H
R
L
S
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
-
P
L
Y
A
K
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
57.97
41%
-92
- C1 -
5DGX
1
?
A:
[5-247]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
T
-----
G
S
---
K
-------
E
------
L
A
K
V
-
D
G
N
-----
V
T
I
-
K
D
L
S
F
A
F
--
G
---
E
---
H
---
K
---
V
--
L
S
G
V
S
V
D
I
K
A
G
Q
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
Y
T
Q
H
---
E
G
E
I
L
L
D
G
V
D
T
R
E
--
L
T
L
E
N
L
R
S
H
L
S
I
V
S
Q
--
N
V
H
L
F
D
D
T
V
Y
N
N
I
A
F
G
----
E
---
V
-
S
E
E
E
V
I
D
A
L
K
R
A
N
A
Y
E
F
V
Q
E
L
S
D
G
I
N
T
N
I
G
N
N
G
S
K
L
S
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
V
L
I
F
D
E
--------------------
L
E
S
L
T
--
K
--
S
C
T
T
I
V
I
--
A
H
R
L
S
T
V
E
N
-
A
D
K
I
V
V
M
D
G
G
R
V
V
E
S
G
K
H
Q
E
L
L
E
Q
--
G
-
G
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
HHSearch
57.74
38%
-91
- C1 -
1MV5
3
LMRA_LACLA
A:
[2-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
-
R
H
V
D
F
A
Y
--
D
---
D
S--
E
---
Q
---
I
--
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
--
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
--
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
--
L
E
G
D--
Y
-
T
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
----
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
--
A
H
R
L
S
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
-
P
L
Y
A
K
Y
V
S
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
57.22
38%
-94
- C1 -
1MV5
3
LMRA_LACLA
A:
[2-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
-
R
H
V
D
F
A
Y
--
D
---
D
S--
E
---
Q
---
I
--
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
--
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
--
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
--
L
E
G
---
D
Y
T
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
----
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
--
A
H
R
L
S
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
-
P
L
Y
A
K
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
56.52
38%
-88
- C1 -
1MV5
3
LMRA_LACLA
C:
[2-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
-
R
H
V
D
F
A
Y
--
D
---
D
S--
E
---
Q
---
I
--
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
--
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
--
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
--
L
E
G
---
D
Y
T
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
----
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
--
A
H
R
L
S
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
-
P
L
Y
A
K
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
54.86
38%
-87
- C1 -
1MV5
3
D:
[2-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
-
R
H
V
D
F
A
Y
--
D
---
D
S--
E
---
Q
---
I
--
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
--
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
--
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
--
L
E
G
---
D
Y
T
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
----
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
--
A
H
R
L
S
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
-
P
L
Y
A
K
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
52.94
33%
-83
- C1 -
4PL0
3
MCJD_ECOLX
B:
[344-566]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----
L
S
I
-
R
E
L
S
F
S
Y
S-
D
---
D
---
K
---
K
---
I
--
L
N
S
V
S
L
D
L
F
T
G
K
M
Y
S
L
T
G
P
S
G
S
G
K
S
T
L
V
K
I
I
S
G
Y
Y
K
N
Y
---
F
G
D
I
Y
L
N
D
I
S
L
R
N
--
I
S
D
E
D
L
N
D
A
I
Y
Y
L
T
Q
--
D
D
Y
I
F
M
D
T
L
R
F
N
L
R
L
A
--
N
Y
D
---
A
-
S
E
N
E
I
F
K
V
L
K
L
A
N
L
-
S
V
V
N
N
E
P
V
S
L
D
T
H
L
I
N
R
G
N
N
Y
S
G
G
Q
K
Q
R
I
S
L
A
R
L
F
L
R
K
P
A
I
I
I
I
D
E
A
T
S
A
L
D
Y
I
N
----
E
S
E
I
L
S
S
I
R
T
H
F
--
P
--
D
A
L
I
I
N
I
--
S
H
R
I
N
L
L
E
C
-
S
D
C
V
Y
V
L
N
E
G
N
I
V
A
S
G
H
F
R
D
L
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
51.84
33%
-84
- C1 -
4PL0
3
MCJD_ECOLX
A:
[344-566]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----
L
S
I
-
R
E
L
S
F
S
Y
S-
D
---
D
---
K
---
K
---
I
--
L
N
S
V
S
L
D
L
F
T
G
K
M
Y
S
L
T
G
P
S
G
S
G
K
S
T
L
V
K
I
I
S
G
Y
Y
K
N
Y
---
F
G
D
I
Y
L
N
D
I
S
L
R
N
--
I
S
D
E
D
L
N
D
A
I
Y
Y
L
T
Q
--
D
D
Y
I
F
M
D
T
L
R
F
N
L
R
L
A
--
N
Y
D
---
A
-
S
E
N
E
I
F
K
V
L
K
L
A
N
L
-
S
V
V
N
N
E
P
V
S
L
D
T
H
L
I
N
R
G
N
N
Y
S
G
G
Q
K
Q
R
I
S
L
A
R
L
F
L
R
K
P
A
I
I
I
I
D
E
A
T
S
A
L
D
Y
I
N
----
E
S
E
I
L
S
S
I
R
T
H
F
--
P
--
D
A
L
I
I
N
I
--
S
H
R
I
N
L
L
E
C
-
S
D
C
V
Y
V
L
N
E
G
N
I
V
A
S
G
H
F
R
D
L
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
51.83
34%
-71
- C1 -
4MKI
4
ECFA2_CALS4
B:
[5-238]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
I
K
-
V
E
N
-----
V
S
F
I
Y
N
E
G
T
P
Y
--
A
---
T
-------
V
---
A
--
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
---
K
G
K
I
Y
I
N
G
I
D
I
T
D
KK
V
S
L
K
D
I
R
K
Q
V
G
L
V
F
Q
YP
E
Y
Q
L
F
E
E
T
V
F
K
D
I
A
F
G
P
S
N
L
G
---
L
-
S
E
E
E
V
K
E
R
V
Y
E
A
------
M
E
I
V
G
I
S
K
E
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
----
K
Q
E
I
L
N
K
I
K
E
I
H
--
D
--
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
50.35
34%
-73
- C1 -
4MKI
4
ECFA2_CALS4
A:
[3-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------
P
------
M
P
I
K
-
V
E
N
-----
V
S
F
I
Y
N
E
G
T
P
Y
--
A
---
T
-------
V
---
A
--
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
---
K
G
K
I
Y
I
N
G
I
D
I
T
D
KK
V
S
L
K
D
I
R
K
Q
V
G
L
V
F
Q
YP
E
Y
Q
L
F
E
E
T
V
F
K
D
I
A
F
G
P
S
N
L
G
---
L
-
S
E
E
E
V
K
E
R
V
Y
E
A
------
M
E
I
V
G
I
S
K
E
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
----
K
Q
E
I
L
N
K
I
K
E
I
H
--
D
--
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------