@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2251: (2016-04-02 )
MIKVTDVEKSYQSAHVFKRRRTPIVKGVSFECPIGATIAIIGESGSGKSTLSRMILGIEKPDKGCVTLNDLPMHKKKVRRHQIGAVFQDYTSSLHPFQTVREILFEVMCQCDGQPKEVMEVQAITLLEEVGLSKAYMDKYPNMLSGGEAQRVAIARAICINPKYILFDEAISSLDMSIQTQILDLLIHLRETRQLSYIFITHDIQAATYLCDQLIIFKNGKIEEQIPTSALHKSDNAYTRELIEKQLSF
Atome Classification :
(40 SA)
-.........10........20........30........40........50........60.----------....-----.-----..70...-------------..---------------.-----..----80--.........90--.....-...100.-.......---110--..---......120..-.....130.-.-......140.......150.......160.......170.......180.......190.......200.......210.......220.-.......230.-..-.-....240...--------------------------....------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MIKV
T
D
V
E
K
S
Y
Q
S
A
H
V
F
K
RRRTPIVKGV
S
F
ECPIG
A
T
I
A
I
I
GESGS
G
K
S
T
L
S
R
M
I
LGIEKPD----------KG
C
V
-----T-----LNDLP
M
H
-------------
K
K
---------------
K
-----
V
R
----
R
---
H
Q
I
G
A
V
F
Q
D
Y
T--SSLH
P
-
F
Q
T
V
-
R
E
-
I
L
F
E
V
M
C
---QC---DG---Q
P
K
E
V
M
E
V
Q
A
I
-
T
L
L
E
E
VG-L-
S
-
K
A
Y
M
D
KYPNMLSGGEA
Q
R
V
A
I
A
R
A
I
CINP
K
Y
I
L
F
D
E
A
I
S
S
L
D
M
S
I
Q
T
Q
I
L
D
L
L
I
H
L
R
E
TR
Q
L
S
Y
I
F
I
THD
I
Q
A
A
T
Y
L
C
D
Q
L
I
I
FKNGK-I-EEQIP
T
S
A
-LH-KS-D-
N
A
Y
T
R
E
L
I
E
K
--------------------------QLSF------------------------------------------------------------------
87
Fugue
92.66
34%
-115
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
----
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----------
E
G
S
V
-----
L
VDGQE
L
T
T
L
S
E
S
-------------
E
L
---------------
T
-----
K
A
----
R
---
R
Q
I
G
M
I
F
Q
H
F
----
N
L
L
S
-
S
R
T
V
-
F
G
-
N
V
A
L
P
L
----
E
L
---
D
N
---
T
P
K
D
E
V
K
R
R
V
T
-
E
L
L
S
L
V
G
-
L
-
G
-
D
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
-
L
-
I
E
Q
D
T
V
S
E
-
V
F
S
H
P
-
K
-
T
P
L
A
Q
K
F
I
Q
S
TLHLDIPEDYQERLQAEPFTDCVPML
R
L
E
F
TGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV
21
PsiBlast_CBE
90.97
35%
-125
- C1 -
4YMV
1
?
A:
[1-240]
-
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
V
L
K
--------
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
----------
K
G
E
V
-----
F
-----
I
D
G
V
K
I
N
-------------
N
G
---------------
K
-----
V
N
I
N
K
V
R
---
Q
K
V
G
M
V
F
Q
H
F
----
N
L
F
P
-
H
L
T
A
-
I
E
-
N
I
T
L
A
P
V
---
K
V
---
K
K
---
M
N
K
K
E
A
E
E
L
A
V
-
D
L
L
A
K
V
G
-
L
-
L
-
D
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
-
I
V
E
E
G
T
P
E
E
I
-
F
Y
-
R
A
-
K
-
N
E
R
T
R
E
F
L
S
K
--------------------------
I
L
--------------------------------------------------------------------
22
PsiBlast_CBE
89.51
35%
-129
- C1 -
4YMU
2
?
A:
[1-240]
-
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
V
L
K
--------
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
----------
K
G
E
V
-----
F
-----
I
D
G
V
K
I
N
-------------
N
G
---------------
K
-----
V
N
I
N
K
V
R
---
Q
K
V
G
M
V
F
Q
H
F
----
N
L
F
P
-
H
L
T
A
-
I
E
-
N
I
T
L
A
P
V
---
K
V
---
K
K
---
M
N
K
K
E
A
E
E
L
A
V
-
D
L
L
A
K
V
G
-
L
-
L
-
D
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
-
I
V
E
E
G
T
P
E
E
I
-
F
Y
-
R
A
-
K
-
N
E
R
T
R
E
F
L
S
K
--------------------------
I
L
--------------------------------------------------------------------
80
HHSearch
88.84
33%
-122
- C1 -
1B0U
4
HISP_SALTY
A:
[7-254]
--
L
H
V
I
D
L
H
K
R
Y
G
G
--------
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
----------
E
G
A
I
-----
I
-----
V
N
G
Q
N
I
N
-------------
L
V
R
D
KDGQLKVAD
K
N
Q
L
R
-----
L
L
----
R
---
T
R
L
T
M
V
F
Q
H
F
N
----
L
W
S
-
H
M
T
V
-
L
E
-
N
V
M
E
A
P
I
---
Q
V
---
L
G
---
L
S
K
H
D
A
R
E
R
A
L
-
K
Y
L
A
K
V
G
-
I
-
D
-
E
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
-
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
-
I
-
E
E
E
G
D
P
E
Q
-
V
F
-
G
N
P
Q
-
S
P
R
L
Q
Q
F
L
K
-------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.78
35%
-126
- C1 -
4YMV
1
?
J:
[1-240]
-
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
V
L
K
--------
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
----------
K
G
E
V
-----
F
-----
I
D
G
V
K
I
N
-------------
N
G
---------------
K
-----
V
N
INKV
R
---
Q
K
V
G
M
V
F
Q
H
F
----
N
L
F
P
-
H
L
T
A
-
I
E
-
N
I
T
L
A
P
V
---
K
V
---
K
K
---
M
N
K
K
E
A
E
E
L
A
V
-
D
L
L
A
K
V
G
-
L
-
L
-
D
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
-
I
V
E
E
G
T
P
E
E
I
-
F
Y
-
R
A
-
K
-
N
E
R
T
R
E
F
L
S
K
--------------------------
I
L
--------------------------------------------------------------------
73
HHSearch
86.96
35%
-127
- C1 -
3TUI
1
METN_ECOLI
C:
[24-251]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
----
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----------
E
G
S
V
-----
L
-----
V
D
G
Q
E
L
T
-------------
T
L
---------------
S
ESELT
K
A
----
R
---
R
Q
I
G
M
I
F
Q
H
F
N
----
L
L
S
-
S
R
T
V
-
F
G
-
N
V
A
L
P
L
E
---
L
D
---
N
T
----
P
K
D
E
V
K
R
R
V
T
-
E
L
L
S
L
V
G
-
L
-
G
--
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
-
L
-
I
E
Q
D
T
V
S
E
-
V
-----------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
86.73
33%
-122
- C1 -
4U02
1
?
C:
[4-242]
-
I
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
--------
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
----------
E
G
E
V
-----
V
-----
V
D
G
L
S
V
K
-------------
D
D
---------------
R
-----
A
L
----
R
EIR
R
E
V
G
M
V
F
Q
Q
F
----
N
L
F
P
-
H
M
T
V
-
L
E
-
N
V
T
L
A
P
M
---
R
V
---
R
R
---
W
P
R
E
K
A
E
K
K
A
L
-
E
L
L
E
R
V
G
I
L
-
D
-
Q
A
R
--
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
-
I
V
E
E
G
R
P
E
E
I
-
F
T
-
R
P
-
K
-
E
E
R
T
R
S
F
L
Q
R
--------------------------
V
L
--------------------------------------------------------------------
2
PsiBlast_PDB
86.55
35%
-126
- C1 -
4YMT
-
?
J:
[1-240]
-
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
V
L
K
--------
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
----------
K
G
E
V
-----
F
-----
I
D
G
V
K
I
N
-------------
N
G
---------------
K
-----
V
N
INKV
R
---
Q
K
V
G
M
V
F
Q
H
F
----
N
L
F
P
-
H
L
T
A
-
I
E
-
N
I
T
L
A
P
V
---
K
V
---
K
K
---
M
N
K
K
E
A
E
E
L
A
V
-
D
L
L
A
K
V
G
-
L
-
L
-
D
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
-
I
V
E
E
G
T
P
E
E
I
-
F
Y
-
R
A
-
K
-
N
E
R
T
R
E
F
L
S
K
--------------------------
I
L
--------------------------------------------------------------------
1
PsiBlast_PDB
86.36
35%
-129
- C1 -
4YMS
-
?
J:
[1-240]
-
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
V
L
K
--------
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
----------
K
G
E
V
-----
F
-----
I
D
G
V
K
I
N
-------------
N
G
---------------
K
-----
V
N
INKV
R
---
Q
K
V
G
M
V
F
Q
H
F
----
N
L
F
P
-
H
L
T
A
-
I
E
-
N
I
T
L
A
P
V
---
K
V
---
K
K
---
M
N
K
K
E
A
E
E
L
A
V
-
D
L
L
A
K
V
G
-
L
-
L
-
D
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
-
I
V
E
E
G
T
P
E
E
I
-
F
Y
-
R
A
-
K
-
N
E
R
T
R
E
F
L
S
K
--------------------------
I
L
--------------------------------------------------------------------
5
PsiBlast_PDB
86.15
35%
-127
- C1 -
4YMW
-
?
J:
[1-240]
-
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
V
L
K
--------
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
----------
K
G
E
V
-----
F
-----
I
D
G
V
K
I
N
-------------
N
G
---------------
K
-----
V
N
INKV
R
---
Q
K
V
G
M
V
F
Q
H
F
----
N
L
F
P
-
H
L
T
A
-
I
E
-
N
I
T
L
A
P
V
---
K
V
---
K
K
---
M
N
K
K
E
A
E
E
L
A
V
-
D
L
L
A
K
V
G
-
L
-
L
-
D
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
-
I
V
E
E
G
T
P
E
E
I
-
F
Y
-
R
A
-
K
-
N
E
R
T
R
E
F
L
S
K
--------------------------
I
L
--------------------------------------------------------------------
3
PsiBlast_PDB
85.96
35%
-127
- C1 -
4YMU
2
?
J:
[1-240]
-
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
V
L
K
--------
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
----------
K
G
E
V
-----
F
-----
I
D
G
V
K
I
N
-------------
N
G
---------------
K
-----
V
N
INKV
R
---
Q
K
V
G
M
V
F
Q
H
F
----
N
L
F
P
-
H
L
T
A
-
I
E
-
N
I
T
L
A
P
V
---
K
V
---
K
K
---
M
N
K
K
E
A
E
E
L
A
V
-
D
L
L
A
K
V
G
-
L
-
L
-
D
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
-
I
V
E
E
G
T
P
E
E
I
-
F
Y
-
R
A
-
K
-
N
E
R
T
R
E
F
L
S
K
--------------------------
I
L
--------------------------------------------------------------------
7
PsiBlast_PDB
85.59
33%
-119
- C1 -
4U02
1
?
A:
[4-242]
-
I
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
--------
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
----------
E
G
E
V
-----
V
-----
V
D
G
L
S
V
K
-------------
D
D
---------------
R
-----
A
L
----
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
----
N
L
F
P
-
H
M
T
V
-
L
E
-
N
V
T
L
A
P
M
---
R
V
---
R
R
---
W
P
R
E
K
A
E
K
K
A
L
-
E
L
L
E
R
V
G
I
L
-
D
-
Q
A
R
--
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
-
I
V
E
E
G
R
P
E
E
I
-
F
T
-
R
P
-
K
-
E
E
R
T
R
S
F
L
Q
R
--------------------------
V
L
--------------------------------------------------------------------
29
PsiBlast_CBE
85.38
34%
-117
- C1 -
3TUI
1
METN_ECOLI
H:
[24-245]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
----
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----------
E
G
S
V
LVDGQ
E
-----
L
T
T
L
S
E
S
-------------
E
L
---------------
T
-----
K
A
----
R
---
R
Q
I
G
M
I
F
Q
H
F
N
LL
S
S
R
T
V
-
F
G
N
V
-------
A
L
P
L
---
E
L
---
D
N
---
T
P
K
D
E
V
K
R
R
V
T
-
E
L
L
S
L
V
G
-
L
-
G
-
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
-
L
-
I
E
Q
------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
84.74
34%
-115
- C1 -
3TUI
1
METN_ECOLI
G:
[24-245]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
----
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----------
E
G
S
V
LVDGQ
E
-----
L
T
T
L
S
E
S
-------------
E
L
---------------
T
-----
K
A
----
R
---
R
Q
I
G
M
I
F
Q
H
F
N
LL
S
S
R
T
V
-
F
G
N
V
-------
A
L
P
L
---
E
L
---
D
N
---
T
P
K
D
E
V
K
R
R
V
T
-
E
L
L
S
L
V
G
-
L
-
G
-
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
-
L
-
I
E
Q
------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
84.64
34%
-119
- C1 -
3TUZ
1
METN_ECOLI
C:
[24-245]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
----
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----------
E
G
S
V
LVDGQ
E
-----
L
T
T
L
S
E
S
-------------
E
L
---------------
T
-----
K
A
----
R
---
R
Q
I
G
M
I
F
Q
H
F
N
LL
S
S
R
T
V
-
F
G
N
V
-------
A
L
P
L
---
E
L
---
D
N
---
T
P
K
D
E
V
K
R
R
V
T
-
E
L
L
S
L
V
G
-
L
-
G
-
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
-
L
-
I
E
Q
------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
84.26
33%
-118
- C1 -
4U02
1
?
B:
[4-242]
-
I
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
--------
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
----------
E
G
E
V
-----
V
-----
V
D
G
L
S
V
K
-------------
D
D
---------------
R
-----
A
L
----
R
EIR
R
E
V
G
M
V
F
Q
Q
F
----
N
L
F
P
-
H
M
T
V
-
L
E
-
N
V
T
L
A
P
M
---
R
V
---
R
R
---
W
P
R
E
K
A
E
K
K
A
L
-
E
L
L
E
R
V
G
I
L
-
D
-
Q
A
R
--
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
-
I
V
E
E
G
R
P
E
E
I
-
F
T
-
R
P
-
K
-
E
E
R
T
R
S
F
L
Q
R
--------------------------
V
L
--------------------------------------------------------------------
6
PsiBlast_PDB
83.92
33%
-120
- C1 -
4U00
3
?
A:
[4-242]
-
I
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
--------
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
----------
E
G
E
V
-----
V
-----
V
D
G
L
S
V
K
-------------
D
D
---------------
R
-----
A
L
----
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
----
N
L
F
P
-
H
M
T
V
-
L
E
-
N
V
T
L
A
P
M
---
R
V
---
R
R
---
W
P
R
E
K
A
E
K
K
A
L
-
E
L
L
E
R
V
G
I
L
-
D
-
Q
A
R
--
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
-
I
V
E
E
G
R
P
E
E
I
-
F
T
-
R
P
-
K
-
E
E
R
T
R
S
F
L
Q
R
--------------------------
V
L
--------------------------------------------------------------------
9
PsiBlast_PDB
83.53
34%
-118
- C1 -
3TUI
1
METN_ECOLI
C:
[24-245]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
----
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----------
E
G
S
V
LVDGQ
E
-----
L
T
T
L
S
E
S
-------------
E
L
---------------
T
-----
K
A
----
R
---
R
Q
I
G
M
I
F
Q
H
F
N
LL
S
S
R
T
V
-
F
G
N
V
-------
A
L
P
L
---
E
L
---
D
N
---
T
P
K
D
E
V
K
R
R
V
T
-
E
L
L
S
L
V
G
-
L
-
G
-
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
-
L
-
I
E
Q
------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
83.50
34%
-115
- C1 -
3TUZ
1
METN_ECOLI
H:
[24-245]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
----
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----------
E
G
S
V
LVDGQ
E
-----
L
T
T
L
S
E
S
-------------
E
L
---------------
T
-----
K
A
----
R
---
R
Q
I
G
M
I
F
Q
H
F
N
LL
S
S
R
T
V
-
F
G
N
V
-------
A
L
P
L
---
E
L
---
D
N
---
T
P
K
D
E
V
K
R
R
V
T
-
E
L
L
S
L
V
G
-
L
-
G
-
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
-
L
-
I
E
Q
------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
83.42
33%
-118
- C1 -
4U02
1
?
D:
[4-242]
-
I
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
--------
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
----------
E
G
E
V
-----
V
-----
V
D
G
L
S
V
K
-------------
D
D
---------------
R
-----
A
L
----
R
EIR
R
E
V
G
M
V
F
Q
Q
F
----
N
L
F
P
-
H
M
T
V
-
L
E
-
N
V
T
L
A
P
M
---
R
V
---
R
R
---
W
P
R
E
K
A
E
K
K
A
L
-
E
L
L
E
R
V
G
I
L
-
D
-
Q
A
R
--
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
-
I
V
E
E
G
R
P
E
E
I
-
F
T
-
R
P
-
K
-
E
E
R
T
R
S
F
L
Q
R
--------------------------
V
L
--------------------------------------------------------------------
53
PsiBlast_CBE
79.77
33%
-126
- C1 -
1B0U
4
HISP_SALTY
A:
[7-234]
--
L
H
V
I
D
L
H
K
R
Y
G
G
H
E
V
--------
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
----------
E
G
A
I
-----
I
-----
V
N
G
Q
N
I
N
L
V
R
D
KDGQLKVAD
K
N
---------------
Q
-----
L
R
L
L
--
R
---
T
R
L
T
M
V
F
Q
H
F
----
N
L
W
S
-
H
M
T
V
-
L
E
-
N
V
M
E
A
P
I
---
Q
V
---
L
G
---
L
S
K
H
D
A
R
E
R
A
L
-
K
Y
L
A
K
V
G
-
I
-
D
-
E
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
G
K
-
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
-
I
-
E
E
E
------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
76.88
32%
-116
- C1 -
2OLK
1
?
D:
[24-261]
-
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
--------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
----------
E
G
E
I
-----
I
-----
I
D
G
I
N
L
K
-------------
A
K
---------------
D
-----
T
N
LNKV
R
---
E
E
V
G
M
V
F
Q
R
F
----
N
L
F
P
-
H
M
T
V
-
L
N
-
N
I
T
L
A
P
M
---
K
V
---
R
K
---
W
P
R
E
K
A
E
A
K
A
M
-
E
L
L
D
K
V
G
-
L
K
D
-
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-
E
E
G
K
P
E
D
L
-
F
D
-
R
P
-
Q
-
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
76.01
32%
-114
- C1 -
2OLK
2
?
B:
[24-261]
-
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
--------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
----------
E
G
E
I
-----
I
-----
I
D
G
I
N
L
K
-------------
A
K
---------------
D
-----
T
N
LNKV
R
---
E
E
V
G
M
V
F
Q
R
F
----
N
L
F
P
-
H
M
T
V
-
L
N
-
N
I
T
L
A
P
M
---
K
V
---
R
K
---
W
P
R
E
K
A
E
A
K
A
M
-
E
L
L
D
K
V
G
-
L
K
D
-
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-
E
E
G
K
P
E
D
L
-
F
D
-
R
P
-
Q
-
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
75.99
32%
-120
- C1 -
2OLJ
4
?
A:
[24-261]
-
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
--------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
----------
E
G
E
I
-----
I
-----
I
D
G
I
N
L
K
-------------
A
K
---------------
D
-----
T
N
L
N
K
V
R
---
E
E
V
G
M
V
F
Q
R
F
----
N
L
F
P
-
H
M
T
V
-
L
N
-
N
I
T
L
A
P
M
---
K
V
---
R
K
---
W
P
R
E
K
A
E
A
K
A
M
-
E
L
L
D
K
V
G
-
L
K
D
-
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-
E
E
G
K
P
E
D
L
-
F
D
-
R
P
-
Q
-
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
74.92
32%
-111
- C1 -
3C41
3
?
J:
[3-240]
-
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
--------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
----------
E
G
E
I
-----
I
-----
I
D
G
I
N
L
K
-------------
A
K
---------------
D
-----
T
N
LNKV
R
---
E
E
V
G
M
V
F
Q
R
F
----
N
L
F
P
-
H
M
T
V
-
L
N
-
N
I
T
L
A
P
M
---
K
V
---
R
K
---
W
P
R
E
K
A
E
A
K
A
M
-
E
L
L
D
K
V
G
-
L
K
D
-
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-
E
E
G
K
P
E
D
L
-
F
D
-
R
P
-
Q
-
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
73.91
32%
-118
- C1 -
3C4J
3
?
A:
[24-261]
-
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
--------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
----------
E
G
E
I
-----
I
-----
I
D
G
I
N
L
K
-------------
A
K
---------------
D
-----
T
N
L
N
K
V
R
---
E
E
V
G
M
V
F
Q
R
F
----
N
L
F
P
-
H
M
T
V
-
L
N
-
N
I
T
L
A
P
M
---
K
V
---
R
K
---
W
P
R
E
K
A
E
A
K
A
M
-
E
L
L
D
K
V
G
-
L
K
D
-
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-
E
E
G
K
P
E
D
L
-
F
D
-
R
P
-
Q
-
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
73.69
32%
-115
- C1 -
2OLK
1
?
A:
[24-261]
-
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
--------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
----------
E
G
E
I
-----
I
-----
I
D
G
I
N
L
K
-------------
A
K
---------------
D
-----
T
N
L
N
K
V
R
---
E
E
V
G
M
V
F
Q
R
F
----
N
L
F
P
-
H
M
T
V
-
L
N
-
N
I
T
L
A
P
M
---
K
V
---
R
K
---
W
P
R
E
K
A
E
A
K
A
M
-
E
L
L
D
K
V
G
-
L
K
D
-
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-
E
E
G
K
P
E
D
L
-
F
D
-
R
P
-
Q
-
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
73.60
32%
-116
- C1 -
2Q0H
4
?
A:
[24-261]
-
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
--------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
----------
E
G
E
I
-----
I
-----
I
D
G
I
N
L
K
-------------
A
K
---------------
D
-----
T
N
L
N
K
V
R
---
E
E
V
G
M
V
F
Q
R
F
----
N
L
F
P
-
H
M
T
V
-
L
N
-
N
I
T
L
A
P
M
---
K
V
---
R
K
---
W
P
R
E
K
A
E
A
K
A
M
-
E
L
L
D
K
V
G
-
L
K
D
-
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-
E
E
G
K
P
E
D
L
-
F
D
-
R
P
-
Q
-
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
73.32
32%
-112
- C1 -
2Q0H
4
?
B:
[24-261]
-
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
--------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
----------
E
G
E
I
-----
I
-----
I
D
G
I
N
L
K
-------------
A
K
---------------
D
-----
T
N
L
N
K
V
R
---
E
E
V
G
M
V
F
Q
R
F
----
N
L
F
P
-
H
M
T
V
-
L
N
-
N
I
T
L
A
P
M
---
K
V
---
R
K
---
W
P
R
E
K
A
E
A
K
A
M
-
E
L
L
D
K
V
G
-
L
K
D
-
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-
E
E
G
K
P
E
D
L
-
F
D
-
R
P
-
Q
-
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
73.08
32%
-117
- C1 -
2OLK
1
?
C:
[24-261]
-
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
--------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
----------
E
G
E
I
-----
I
-----
I
D
G
I
N
L
K
-------------
A
K
---------------
D
-----
T
N
LNKV
R
---
E
E
V
G
M
V
F
Q
R
F
----
N
L
F
P
-
H
M
T
V
-
L
N
-
N
I
T
L
A
P
M
---
K
V
---
R
K
---
W
P
R
E
K
A
E
A
K
A
M
-
E
L
L
D
K
V
G
-
L
K
D
-
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-
E
E
G
K
P
E
D
L
-
F
D
-
R
P
-
Q
-
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
72.38
32%
-119
- C1 -
3C4J
4
?
B:
[24-261]
-
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
--------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
----------
E
G
E
I
-----
I
-----
I
D
G
I
N
L
K
-------------
A
K
---------------
D
-----
T
N
LNKV
R
---
E
E
V
G
M
V
F
Q
R
F
----
N
L
F
P
-
H
M
T
V
-
L
N
-
N
I
T
L
A
P
M
---
K
V
---
R
K
---
W
P
R
E
K
A
E
A
K
A
M
-
E
L
L
D
K
V
G
-
L
K
D
-
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-
E
E
G
K
P
E
D
L
-
F
D
-
R
P
-
Q
-
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
72.29
32%
-115
- C1 -
3C41
3
?
K:
[3-240]
-
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
--------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
----------
E
G
E
I
-----
I
-----
I
D
G
I
N
L
K
-------------
A
K
---------------
D
-----
T
N
LNKV
R
---
E
E
V
G
M
V
F
Q
R
F
----
N
L
F
P
-
H
M
T
V
-
L
N
-
N
I
T
L
A
P
M
---
K
V
---
R
K
---
W
P
R
E
K
A
E
A
K
A
M
-
E
L
L
D
K
V
G
-
L
K
D
-
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-
E
E
G
K
P
E
D
L
-
F
D
-
R
P
-
Q
-
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
71.76
32%
-121
- C1 -
4FWI
3
?
B:
[26-265]
---------------------------
G
I
S
L
D
I
L
E
N
S
V
T
A
I
V
G
E
S
A
S
G
K
S
T
I
I
E
A
M
T
K
T
L
P
P
N
GRILSGRVLY
K
G
K
D
-----
L
-----
L
T
M
R
E
E
E
-------------
L
R
---------------
K
-----
I
R
----
W
---
K
E
I
A
L
V
P
Q
A
A
Q
--
Q
S
L
N
P
-
T
M
K
V
-
I
E
--
H
F
K
D
T
V
---
E
A
---
H
G
VRW
S
H
S
E
L
I
E
-
K
A
S
-
E
K
L
R
M
V
R
-
L
-
N
P
E
A
V
L
N
S
Y
P
L
Q
L
S
G
G
M
K
Q
R
V
L
I
A
L
A
L
L
L
D
P
V
V
L
I
L
D
E
P
T
S
A
L
D
V
L
T
Q
A
H
I
I
Q
L
L
K
E
L
K
K
M
L
K
I
T
L
I
F
V
T
H
D
I
A
V
A
A
E
L
A
D
K
V
A
V
I
Y
G
G
N
-
L
-
V
E
Y
N
S
T
F
Q
-
I
F
-
K
N
-
P
L
H
P
Y
T
R
G
L
I
--------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
71.76
32%
-115
- C1 -
2OLJ
3
?
B:
[24-261]
-
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
--------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
----------
E
G
E
I
-----
I
-----
I
D
G
I
N
L
K
-------------
A
K
---------------
D
-----
T
N
LNKV
R
---
E
E
V
G
M
V
F
Q
R
F
----
N
L
F
P
-
H
M
T
V
-
L
N
-
N
I
T
L
A
P
M
---
K
V
---
R
K
---
W
P
R
E
K
A
E
A
K
A
M
-
E
L
L
D
K
V
G
-
L
K
D
-
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-
E
E
G
K
P
E
D
L
-
F
D
-
R
P
-
Q
-
H
E
R
T
K
A
F
L
S
K
------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
69.85
31%
-119
- C1 -
4MKI
4
ECFA2_CALS4
A:
[7-227]
--
I
K
V
E
N
V
S
F
I
Y
N
E
G
T
P
Y
A
---
T
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
----------
K
G
K
I
-----
Y
-----
I
N
G
I
D
I
T
-------------
D
K
---------------
K
-----
V
S
L
K
D
I
R
---
K
Q
V
G
L
V
F
Q
--------
Y
P
E
Y
Q
L
F
-
E
E
-
T
V
F
K
D
I
A
F
G
P
S
N
---
L
G
---
L
S
E
E
E
V
K
E
R
V
Y
-
E
A
M
E
I
V
G
-
I
-
S
-
K
E
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
-
I
-
E
--------------------------------------------------------------------------------------------------------------------------
71
HHSearch
69.36
30%
-119
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-242]
-
A
L
H
I
G
H
L
S
K
S
F
Q
N
--------
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
----------
S
G
E
I
-----
S
-----
L
S
G
K
T
I
F
-------------
S
K
N
T
N
L
-----------
P
-----
V
R
----
E
---
R
R
L
G
Y
L
V
Q
E
G
V
----
L
F
P
-
H
L
T
V
-
Y
R
-
N
I
A
Y
G
L
G
---
N
G
---
K
G
----
R
T
A
Q
E
R
Q
R
I
E
-
A
M
L
E
L
T
G
-
I
-
S
--
E
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
-
I
-
L
Q
T
A
S
P
H
E
L
Y
R
-
Q
P
-
A
-
D
L
D
A
A
L
----------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
69.32
31%
-122
- C1 -
4MKI
4
ECFA2_CALS4
B:
[7-227]
--
I
K
V
E
N
V
S
F
I
Y
N
E
G
T
P
Y
A
---
T
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
----------
K
G
K
I
-----
Y
-----
I
N
G
I
D
I
T
-------------
D
K
---------------
K
-----
V
S
L
K
D
I
R
---
K
Q
V
G
L
V
F
Q
--------
Y
P
E
Y
Q
L
F
-
E
E
-
T
V
F
K
D
I
A
F
G
P
S
N
---
L
G
---
L
S
E
E
E
V
K
E
R
V
Y
-
E
A
M
E
I
V
G
-
I
-
S
-
K
E
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
-
I
-
E
--------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
63.98
32%
-125
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[5-217]
--
L
H
I
G
H
L
S
K
S
F
Q
N
--------
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
----------
S
G
E
I
-----
S
-----
L
S
G
K
T
I
F
-------------
S
K
---------------
N
TNLP-
V
R
----
E
---
R
R
L
G
Y
L
V
Q
E
----
G
V
L
F
P
-
H
L
T
V
Y
R
N
-
I
A
Y
G
L
------
G
---
N
G
---
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
-
I
-
S
-
E
-
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
-
I
----------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
62.64
32%
-123
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[5-222]
--
L
H
I
G
H
L
S
K
S
F
Q
N
--------
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
----------
S
G
E
I
-----
S
-----
L
S
G
K
T
I
F
-------------
S
K
---------------
N
T
N
L
P
-
V
R
----
E
---
R
R
L
G
Y
L
V
Q
E
----
G
V
L
F
P
-
H
L
T
V
Y
R
N
-
I
A
Y
G
L
------
G
---
N
G
---
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
-
I
-
S
-
E
-
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
-
I
----------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
36.71
31%
-125
- C1 -
1VCI
1
?
A:
[38-227]
-----------------------------------
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
----------
E
G
R
I
-----
Y
-----
F
G
D
R
D
V
T
-------------
Y
L
---------------
P
-----
P
K
----
D
---
R
N
I
S
M
V
F
Q
-----------
H
M
T
V
-
Y
E
N
I
A
F
P
L
-----
K
K
FP
K
D
E
---
I
D
K
R
V
R
W
A
A
E
L
-
L
Q
I
E
E
L
---------
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
-
L
----------------------------------------------------------------------------------------------------------------------------