@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2288: (2016-04-02 )
MKKIKKAIIPAAGLGTRFLPATKAMPKEMLPILDKPTIQYIVEEAARAGIEDIIIVTGRHKRAIEDHFDSQKELEMVLKEKGKSELLEKVQYSTELANIFYVRQKEQKGLGHAISSARQFIGNEPFAVLLGDDIVESEVPAVKQLIDVYEETGHSVIGVQEVPEADTHRYGIIDPLTKNGRQYEVKKFVEKPAQGTAPSNLAIMGRYVLTPEIFDYLKTQKEGAGNEIQLTDAIERMNNDNQVYAYDFEGERYDVGEKLGFVKTTIEYALKDDSMREELTRFIKALGL
Atome Classification :
(21 SA)
.........10........20........30........40........50..-...-----...60........70........80...-.....90........100.....-..110.......120--...--....130..-...-..140---.-.......150.......160.......170--.......--180.......190.......200.......210.......220.......230.......-240-.......250.......260.......270.......280-......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
K
I
K
K
A
IIPAAGLGTRFLPATKAM
P
K
E
M
L
PILDK
P
T
I
Q
Y
I
V
E
E
A
A
RAGI
E
D
I
-
I
I
V
-----TGRH
K
R
A
I
E
D
HFD
S
Q
K
E
L
E
M
V
L
K
EK
G
K
S
-
E
L
L
E
K
V
Q
Y
S
T
E
L
A
N
I
F
Y
V
R
Q
K
E
Q-KGL
G
H
A
I
S
S
A
R
Q
F
IG--NE
P
--
F
A
V
L
LGD
D
I
-
V
E
S
-
E
V
P
A
----
V
-
K
Q
L
I
D
V
Y
E
ETG
H
S
V
I
GVQEVPEADTHRYGI--IDPLTKN--G
R
Q
Y
E
V
K
K
F
V
EKPAQGTAPSN
L
A
I
M
G
R
Y
VL
T
P
E
I
F
D
Y
L
K
T
Q
KEGAGN
E
I
Q
L
T
D
A
I
E
RMNN-DN
Q
-
V
Y
A
Y
DFEGERYD
V
G
E
KL
G
F
V
K
T
T
I
E
Y
ALKD
D
S
M
R
E
E
L
T
R
F
-
I
K
A
LGL
26
PsiBlast_CBE
94.95
51%
-87
- C1 -
2UX8
1
?
C:
[11-297]
I
K
P
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
-
I
F
V
-----
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
K
S
L
D
V
L
D
G
T
R
L
K
P
--
G
N
I
A
Y
V
R
Q
Q
E
P
-
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
--
F
A
V
L
L
P
D
D
F
-
M
F
G
-
Q
P
G
C
----
L
-
K
Q
M
V
D
A
Y
N
K
V
G
G
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
--
I
T
P
G
T
Q
D
--
G
V
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
-------
Q
L
T
D
A
M
Q
R
M
I
G
-
D
Q
P
-
F
H
G
V
T
F
Q
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
D
L
E
P
A
V
R
A
F
A
V
K
A
L
G
-
27
PsiBlast_CBE
92.86
51%
-88
- C1 -
2UX8
1
?
B:
[11-297]
I
K
P
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
-
I
F
V
-----
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
K
S
L
D
V
L
D
G
T
R
L
K
P
--
G
N
I
A
Y
V
R
Q
Q
E
P
-
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
--
F
A
V
L
L
P
D
D
F
-
M
F
G
-
Q
P
G
C
----
L
-
K
Q
M
V
D
A
Y
N
K
V
G
G
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
--
I
T
P
G
T
Q
D
--
G
V
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
--------
L
T
D
A
M
Q
R
M
I
G
-
D
Q
P
-
F
H
G
V
T
F
Q
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
D
L
E
P
A
V
R
A
F
A
V
K
A
L
G
-
25
PsiBlast_CBE
92.82
51%
-89
- C1 -
2UX8
1
?
D:
[11-297]
I
K
P
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
-
I
F
V
-----
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
K
S
L
D
V
L
D
G
T
R
L
K
P
--
G
N
I
A
Y
V
R
Q
Q
E
P
-
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
--
F
A
V
L
L
P
D
D
F
-
M
F
G
-
Q
P
G
C
----
L
-
K
Q
M
V
D
A
Y
N
K
V
G
G
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
--
I
T
P
G
T
Q
D
--
G
V
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
-------
Q
L
T
D
A
M
Q
R
M
I
G
-
D
Q
P
-
F
H
G
V
T
F
Q
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
D
L
E
P
A
V
R
A
F
A
V
K
A
L
G
-
24
PsiBlast_CBE
92.77
51%
-90
- C1 -
2UX8
1
?
E:
[11-297]
I
K
P
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
-
I
F
V
-----
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
K
S
L
D
V
L
D
G
T
R
L
K
P
--
G
N
I
A
Y
V
R
Q
Q
E
P
-
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
--
F
A
V
L
L
P
D
D
F
-
M
F
G
-
Q
P
G
C
----
L
-
K
Q
M
V
D
A
Y
N
K
V
G
G
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
--
I
T
P
G
T
Q
D
--
G
V
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
--------
Q
L
T
D
A
M
Q
R
M
I
G
-
D
Q
P
-
F
H
G
V
T
F
Q
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
D
L
E
P
A
V
R
A
F
A
V
K
A
L
G
-
22
PsiBlast_CBE
92.49
51%
-86
* C1 *
2UX8
1
?
G:
[11-297]
I
K
P
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
-
I
F
V
-----
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
K
S
L
D
V
L
D
G
T
R
L
K
P
--
G
N
I
A
Y
V
R
Q
Q
E
P
-
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
--
F
A
V
L
L
P
D
D
F
-
M
F
G
-
Q
P
G
C
----
L
-
K
Q
M
V
D
A
Y
N
K
V
G
G
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
--
I
T
P
G
T
Q
D
--
G
V
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
K
G
A
G
G
E
I
Q
L
T
D
A
M
Q
R
M
I
G
-
D
Q
P
-
F
H
G
V
T
F
Q
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
D
L
E
P
A
V
R
A
F
A
V
K
A
L
G
-
23
PsiBlast_CBE
91.41
51%
-87
- C1 -
2UX8
1
?
F:
[11-297]
I
K
P
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
-
I
F
V
-----
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
K
S
L
D
V
L
D
G
T
R
L
K
P
--
G
N
I
A
Y
V
R
Q
Q
E
P
-
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
--
F
A
V
L
L
P
D
D
F
-
M
F
G
-
Q
P
G
C
----
L
-
K
Q
M
V
D
A
Y
N
K
V
G
G
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
--
I
T
P
G
T
Q
D
--
G
V
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
K
------
Q
L
T
D
A
M
Q
R
M
I
G
-
D
Q
P
-
F
H
G
V
T
F
Q
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
D
L
E
P
A
V
R
A
F
A
V
K
A
L
G
-
70
HHSearch
87.92
38%
-81
- C1 -
2PA4
2
?
A:
[12-299]
---
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
-
A
I
I
-----
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
G
K
T
-
D
Q
V
E
I
I
R
R
A
A
D
L
I
K
A
V
P
V
T
Q
D
K
P
-
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
DD
E
D
V
--
V
A
V
M
L
P
D
D
L
-
V
L
P
--
T
G
V
----
M
-
E
R
M
A
Q
V
R
A
E
F
G
G
S
V
L
C
A
V
E
V
S
E
A
D
V
S
K
Y
G
I
--
F
E
I
E
A
D
T
KD
S
D
V
K
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
E
G
H
P
-
V
H
I
V
I
H
Q
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
V
Y
G
A
Q
L
K
D
A
-
I
K
Q
I
L
-
2
PsiBlast_PDB
87.41
47%
-83
- C1 -
3JUK
4
?
A:
[2-268]
---
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
-
A
I
V
-----
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
--------
T
N
K
E
-
N
A
L
K
S
I
R
N
I
I
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
-
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
--
F
A
V
I
L
A
D
D
L
C
I
S
H
-
D
H
P
S
----
V
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
--
I
R
G
E
W
L
E
--
E
G
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
A
K
-
R
K
R
-
I
I
A
Y
Q
F
K
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
---------------------
28
PsiBlast_CBE
86.76
47%
-85
- C1 -
3JUK
4
?
D:
[2-268]
---
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
-
A
I
V
-----
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
--------
T
N
K
E
-
N
A
L
K
S
I
R
N
I
I
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
-
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
--
F
A
V
I
L
A
D
D
L
C
I
S
H
-
D
H
P
S
----
V
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
--
I
R
G
E
W
L
E
--
E
G
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
A
K
-
R
K
R
-
I
I
A
Y
Q
F
K
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
---------------------
71
HHSearch
86.71
47%
-85
- C1 -
3JUK
5
?
A:
[1-272]
--
M
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
-
A
I
V
-----
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
--------
T
N
K
E
-
N
A
L
K
S
I
R
N
I
I
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
-
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
--
F
A
V
I
L
A
D
D
L
-
C
I
S
---
H
D
HPS
V
L
-
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
--
I
R
G
E
W
L
E
--
E
G
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
A
K
-
R
K
R
-
I
I
A
Y
Q
F
K
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
Y
K
K
R
-----------------
1
PsiBlast_PDB
85.66
47%
-83
- C1 -
3JUJ
-
?
A:
[2-268]
---
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
-
A
I
V
-----
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
E
I
E
H
Q
I
Q
G
T
N
K
E
-
N
A
L
K
S
I
R
N
I
I
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
-
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
--
F
A
V
I
L
A
D
D
L
C
I
S
H
-
D
H
P
S
----
V
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
--
I
R
G
E
W
L
E
--
E
G
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
A
K
-
R
K
R
-
I
I
A
Y
Q
F
K
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
---------------------
29
PsiBlast_CBE
85.57
47%
-87
- C1 -
3JUK
4
?
C:
[2-268]
---
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
-
A
I
V
-----
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
---------
N
K
E
-
N
A
L
K
S
I
R
N
I
I
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
-
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
--
F
A
V
I
L
A
D
D
L
C
I
S
H
-
D
H
P
S
----
V
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
--
I
R
G
E
W
L
E
--
E
G
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
A
K
-
R
K
R
-
I
I
A
Y
Q
F
K
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
---------------------
21
PsiBlast_CBE
85.23
51%
-100
- C1 -
2UX8
1
?
H:
[11-297]
I
K
P
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
-
I
F
V
-----
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
K
S
L
D
V
L
D
G
T
R
L
K
P
--
G
N
I
A
Y
V
R
Q
Q
E
P
-
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
--
F
A
V
L
L
P
D
D
F
-
M
F
G
-
Q
P
G
C
----
L
-
K
Q
M
V
D
A
Y
N
K
V
G
G
N
L
I
C
A
E
-------------------------
L
T
E
V
K
G
L
--------------
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
---------
Q
L
T
D
A
M
Q
R
M
I
G
-
D
Q
P
-
F
H
G
V
T
F
Q
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
D
L
E
P
A
V
R
A
F
A
V
K
A
L
G
-
33
PsiBlast_CBE
85.10
38%
-84
- C1 -
2PA4
2
?
B:
[10-296]
-
N
A
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
-
A
I
I
-----
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
G
K
T
-
D
Q
V
E
I
I
R
R
A
A
D
L
I
K
A
V
P
V
T
Q
D
K
P
-
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
--
D
D
E
D
V
V
A
V
M
L
P
D
D
L
-
V
----
L
P
T
G
V
--
M
-
E
R
M
A
Q
V
R
A
E
F
G
G
S
V
L
C
A
V
E
V
S
E
A
D
V
S
K
Y
G
I
F
E
I
E
A
D
T
K
D
--
S
D
V
K
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
-
E
G
H
P
V
H
I
V
I
H
Q
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
V
Y
G
A
Q
L
K
D
A
-
I
K
----
3
PsiBlast_PDB
84.95
38%
-87
- C1 -
2PA4
2
?
A:
[12-296]
---
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
-
A
I
I
-----
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
G
K
T
-
D
Q
V
E
I
I
R
R
A
A
D
L
I
K
A
V
P
V
T
Q
D
K
P
-
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
--
D
D
E
D
V
V
A
V
M
L
P
D
D
L
-
V
----
L
P
T
G
V
--
M
-
E
R
M
A
Q
V
R
A
E
F
G
G
S
V
L
C
A
V
E
V
S
E
A
D
V
S
K
Y
G
I
F
E
I
E
A
D
T
K
D
--
S
D
V
K
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
-
E
G
H
P
V
H
I
V
I
H
Q
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
V
Y
G
A
Q
L
K
D
A
-
I
K
----
32
PsiBlast_CBE
84.76
38%
-80
- C1 -
2PA4
2
?
C:
[10-296]
-
N
A
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
-
A
I
I
-----
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
G
K
T
-
D
Q
V
E
I
I
R
R
A
A
D
L
I
K
A
V
P
V
T
Q
D
K
P
-
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
--
D
D
E
DV
V
A
V
M
L
P
D
D
L
-
V
----
L
P
T
GV--
M
-
E
R
M
A
Q
V
R
A
E
F
G
G
S
V
L
C
A
V
E
V
S
E
A
D
V
S
K
Y
G
I
FE
I
E
A
D
T
K
D
--
S
D
V
K
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
-
E
G
H
P
V
H
I
V
I
H
Q
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
V
Y
G
A
Q
L
K
D
A
-
I
K
----
31
PsiBlast_CBE
84.15
38%
-87
- C1 -
2PA4
2
?
D:
[11-296]
--
A
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
-
A
I
I
-----
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
----
D
Q
V
E
I
I
R
R
A
A
D
L
I
K
A
V
P
V
T
Q
D
K
P
-
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
--
D
D
E
DV
V
A
V
M
L
P
D
D
L
-
V
----
L
P
T
GV--
M
-
E
R
M
A
Q
V
R
A
E
F
G
G
S
V
L
C
A
V
E
V
S
E
A
D
V
S
K
Y
G
I
FE
I
E
A
D
T
K
D
--
S
D
V
K
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
-
E
G
H
P
V
H
I
V
I
H
Q
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
V
Y
G
A
Q
L
K
D
A
-
I
K
----
30
PsiBlast_CBE
83.77
47%
-84
- C1 -
3JUK
4
?
B:
[2-268]
---
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
-
A
I
V
-----
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
---------
N
K
E
-
N
A
L
K
S
I
R
N
I
I
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
-
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
--
F
A
V
I
L
A
D
D
L
C
I
S
H
-
D
H
P
S
----
V
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
--
I
R
G
E
W
L
E
--
E
G
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
A
K
-
R
K
R
-
I
I
A
Y
Q
F
K
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
---------------------
9
PsiBlast_PDB
65.62
30%
-73
- C1 -
1IIM
2
RMLA_SALTY
A:
[2-202]
--
K
T
R
K
G
I
I
L
A
G
G
S
G
T
R
L
Y
P
V
T
M
A
V
S
Q
Q
L
L
P
I
Y
D
K
P
M
I
Y
Y
P
L
S
T
L
M
L
A
G
I
R
D
I
-
L
I
I
S
T
PQD
T
P
R
F
Q
Q
L
L
G
D
--
G
S
Q
W
G
L
------------------------
N
L
Q
Y
K
V
Q
P
S
P
-
D
G
L
A
Q
A
F
I
I
G
E
E
F
I
G
--
H
D
D
--
C
A
L
V
L
G
D
N
I
-
F
Y
G
H
D
L
P
K
----
L
-
M
E
-
A
A
V
N
K
E
S
G
A
T
V
F
A
Y
H
---
V
N
D
P
E
R
Y
G
V
--
V
E
-
F
D
Q
K
--
G
T
A
V
S
L
E
---
E
K
P
L
Q
--
P
K
S
N
Y
A
V
T
G
L
Y
F
Y
D
N
S
V
V
E
M
A
K
N
L
K
P
S
A
R
G
E
L
E
I
T
D
-----------------------------------------------------------
12
PsiBlast_PDB
65.07
30%
-74
- C1 -
1MP4
1
RMLA_SALTY
A:
[2-202]
--
K
T
R
K
G
I
I
L
A
G
G
S
G
T
R
L
Y
P
V
T
M
A
V
S
Q
Q
L
L
P
I
Y
D
K
P
M
I
Y
Y
P
L
S
T
L
M
L
A
G
I
R
D
I
-
L
I
I
S
T
PQD
T
P
R
F
Q
Q
L
L
G
D
--
G
S
Q
W
G
L
------------------------
N
L
Q
Y
K
V
Q
P
S
P
-
D
G
L
A
Q
A
F
I
I
G
E
E
F
I
G
--
H
D
D
--
C
A
L
V
L
G
D
N
I
-
F
Y
G
H
D
L
P
K
----
L
-
M
E
-
A
A
V
N
K
E
S
G
A
T
V
F
A
Y
H
---
V
N
D
P
E
R
Y
G
V
--
V
E
-
F
D
Q
A
--
G
T
A
V
S
L
E
---
E
K
P
L
Q
--
P
K
S
N
Y
A
V
T
G
L
Y
F
Y
D
N
S
V
V
E
M
A
K
N
L
K
P
S
A
R
G
E
L
E
I
T
D
-----------------------------------------------------------
5
PsiBlast_PDB
62.54
31%
-71
- C1 -
2GGQ
2
?
A:
[2-232]
-----
K
A
F
I
L
A
A
G
S
G
E
R
L
E
P
I
T
H
T
R
P
K
A
F
V
P
I
L
S
K
P
L
I
E
Y
Q
I
E
Y
L
R
K
C
G
I
R
D
I
T
V
I
V
-----
S
S
K
N
K
------------------------
E
Y
F
E
K
-----
K
L
K
E
I
S
I
V
T
Q
K
D
D
I
K
G
T
G
A
A
I
L
S
A
K
F
-----
N
D
E
--
A
L
I
I
Y
G
D
L
F
-
F
S
N
-
E
---------
K
E
I
C
N
I
I
T
L
K
E
N
A
I
I
G
V
K
V
S
N
P
K
D
---
Y
G
V
--
L
--
V
L
D
N
----
Q
N
N
L
S
K
I
I
E
K
P
E
--
I
P
P
S
N
L
I
N
A
G
I
Y
K
L
N
S
D
I
F
T
Y
L
D
K
I
S
I
S
E
R
G
E
L
E
L
T
D
A
I
N
L
M
A
K
-
D
H
R
-
V
K
V
I
E
Y
E
G
Y
W
M
D
I
G
K
P
W
N
I
I
D
V
N
-
K
W
A
L
D
N
L
V
F
S
Q
N
L
----------