@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2344: (2016-04-03 )
MANTKKTTLDITGMTCAACSNRIEKKLNKLDDVNAQVNLTTEKATVEYNPDQHDVQEFINTIQHLGYGVTVETVELDITGMTCAACSSRIEKVLNKMNGVQNATVNLTTEQAKVDYYPEETDADKLVTRIQKLGYDASIKDNNKDQTSRKAEALQHKLIKLIISAVLSLPLLMLMFVHLFNMHIPALFTNPWFQFILATPVQFIIGWQFYVGAYKNLRNGGANMDVLVAVGTSAAYFYSIYEMVRWLNGSTTQPHLYFETSAVLLTLILFGKYLEARAKSQTTNALGELLSLQAKEARILKDGNEVMIPLNEVHVGDTLIVKPGEKIPVDGKIIKGMTAIDESMLTGESIPVEKNVDDTVIGSTMNKNGTITMTATKVGGDTALANIIKVVEEAQSSKAPIQRLADIISGYFVPIVVGIALLIFIVWITLVTPGTFEPALVASISVLVIACPCALGLATPTSIMVGTGRAAENGILFKGGEFVERTHQIDTIVLDKTGTITNGRPVVTDYHGDNQTLQLLATAEKDSEHPLAEAIVNYAKEKQLTLTETTTFKAVPGHGIEATIDHHHILVGNRKLMADNDISLPKHISDDLTHYERDGKTAMLIAVNYSLTGIIAVADTVKDHAKDAIKQLHDMGIEVAMLTGDNKNTAQAIAKQVGIDTVIADILPEEKAAQIAKLQQQGKKVAMVGDGVNDAPALVKADIGIAIGTGTEVAIEAADITILGGDLMLIPKAIYASKATIRNIRQNLFWAFGYNIAGIPIAALGLLAPWVAGAAMALSSVSVVTNALRLKKMRLEPRRKDA
Atome Classification :
(26 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220-.......230.......240......-------.250...----------....260.......270.......280.......290.....-..300........310.......320.......330.....-..340.......350.....----------..----------360.......370.......380.......390.......400.......410.......420.......430........440.......450.......460.......470.......480.......490.......500...----....--------------------510-.-----..-.------------------------...-..520...------------------------....530....---...540....-------...550.......560.---------.....---------.570.......580.-------------..----....590---......------..600.....------------------------..------------------------610.......620.......630.......640.......650.......-----------------------------------------------------660----------------------------------------------------........670.......680.......690.......700......-.710.......720.......730.......740.......750.......760.------..-------.-------.--------.--.770.......780.......790.......800------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MANT
K
K
T
T
L
D
ITG
M
T
C
A
A
C
S
N
R
I
E
K
K
L
N
K
LDDVN
A
Q
V
N
L
T
T
E
K
A
T
V
E
YNP
D
Q
H
D
V
Q
E
F
I
N
T
I
Q
HLGYG
V
T
V
E
T
V
E
L
D
ITG
M
T
C
A
A
C
S
S
R
I
E
K
V
L
N
K
MNGVQN
A
T
V
N
L
T
TEQAKVDYYPEET
D
A
D
K
L
V
T
R
I
Q
KLGYDASIKDNNK
D
Q
T
S
R
K
A
E
A
L
Q
H
K
L
I
K
L
I
I
S
A
V
L
S
L
P
L
L
M
L
M
F
V
H
L
F
NMHIP
A
L
FT
N
P
W
F
Q
F
I
L
A
T
P
V
Q
F
I
I
G
W
Q
F
Y
V
G
A
Y
K
N
L
RNGGA-N
M
D
V
L
V
A
VGT
S
A
A
Y
F
Y
S
I
Y
E
M
V
R
W
LN-------GSTTQ
P
H
----------
L
Y
F
E
T
S
A
V
L
L
T
L
I
L
F
G
K
Y
L
E
A
RAKS
Q
T
T
N
A
L
G
E
L
L
S
L
Q
A
K
E
A
-RILK-DG
N
E
V
M
I
PLNEVHVG
D
T
L
I
VKPGEKIPVD
G
K
I
I
K
G
M
-
T
A
I
D
E
S
MLTGESIPVEKNVD----------D
T
----------
V
IGSTMNKN
G
T
I
T
M
T
A
TKVGG
D
T
A
L
A
N
I
I
K
V
V
E
E
A
QSSKA
P
I
Q
R
L
A
D
I
I
S
G
Y
F
V
P
I
V
V
G
I
A
L
L
I
F
I
V
W
I
T
LV-TPGTF
E
P
A
L
V
A
S
I
S
V
L
V
I
ACPCALGLATP
T
S
I
M
V
GTGRAAEN
G
I
L
FKG
G
E
F
V
E
RTHQ
I
D
T
I
V
LDKTGTITNG
R
P
----
V
V
T
D
--------------------Y---H-----GD-N------------------------
Q
T
L
-
Q
L
L
A
TAEK------------------------DSEH
P
L
A
E
A
I
V
---
N
Y
A
KEK
Q
L
T
L
-------TET
T
T
F
KAVPGHG
I
E
A
T
---------IDH
H
H
---------
I
L
VGN
R
K
LMADNDIS-------------L
P
----
K
H
I
S
D
D
----
L
T
H
YER------DG
K
T
A
M
L
I
A
V
------------------------NY------------------------S
L
T
G
I
I
A
V
A
D
T
V
K
D
H
A
K
D
A
I
K
Q
L
H
DMG
I
E
V
A
M
L
TGDNK
N
T
A
Q
A
I
A
K
QV
G
I
-----------------------------------------------------
D
T
-----------------------------------------------------
V
I
A
D
IL
P
E
E
K
A
A
Q
I
A
K
L
Q
QQG
K
K
V
A
M
VGDGVNDA
P
A
L
V
K
A
D
I
G
I
A
IG-TG
T
E
V
A
I
E
A
A
D
I
T
I
LGG
D
L
M
L
I
P
K
A
I
YA
S
K
A
T
I
R
N
I
R
Q
N
L
F
WAFGYNIAG
I
P
I
A
A
------
L
G
-------
L
-------
L
--------
A
--
P
W
V
A
G
A
A
M
A
L
S
S
V
S
V
V
T
N
A
L
R
L
K
K
M
RLEPRRKDA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
88.45
43%
-91
- C1 -
3J09
-
COPA_ARCFU
A:
[16-735]
-----------------------------------------------------------------------
M
E
R
T
V
R
V
T
G
M
T
C
A
M
C
V
K
S
I
E
T
A
V
G
S
L
E
G
V
E
E
V
R
V
N
L
A
T
E
T
A
F
I
R
F
D
E
K
R
I
D
F
E
T
I
K
R
V
I
E
D
L
G
Y
G
V
V
D
E
Q
A
A
V
S
A
---
E
V
E
H
L
S
R
M
K
R
K
L
Y
V
A
A
F
A
G
V
L
L
L
F
L
A
H
F
I
-------
S
L
P
Y
E
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
R
T
L
-
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
A
G
V
-----------
L
P
R
E
Y
----------
S
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
-
V
V
I
R
-
D
G
K
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
-
S
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
W
Y
F
I
A
-
H
A
-
P
L
L
F
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
----
E
V
T
D
--------------------
L
---
V
PLNG-
D
E
-
R
------------------------
E
L
L
-
R
L
A
A
I
A
E
R
------------------------
R
S
E
H
P
I
A
E
A
I
V
---
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
-------------
D
G
---------
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
-------------
V
S
----
N
E
V
E
L
A
----
L
E
K
L
E
R
------
E
A
K
T
A
V
I
V
A
R
------------------------
N
G
------------------------
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
Y
N
V
I
L
I
P
A
A
A
------
G
L
L
Y
P
IFGV
V
-------
F
--------
R
--
P
E
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
P
P
I
R
R
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.94
42%
-93
- C1 -
3J09
-
COPA_ARCFU
A:
[22-734]
-----------------------------------------------------------------------------
V
T
G
M
T
C
A
M
C
V
K
S
I
E
T
A
V
G
S
L
E
G
V
E
E
V
R
V
N
L
A
T
E
T
A
F
I
R
F
D
E
K
R
I
D
F
E
T
I
K
R
V
I
E
D
L
G
Y
G
V
V
---
D
E
Q
A
A
V
S
A
E
V
E
H
L
S
R
M
K
R
K
L
Y
V
A
A
F
A
G
V
L
L
L
F
L
A
-------
H
F
I
S
L
P
Y
E
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
R
T
L
-
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
A
-----------
G
V
L
P
R
E
Y
----------
S
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
-
V
V
I
R
-
D
G
K
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
-
S
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
W
Y
F
I
A
H
A
P
L
L
F
--
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
----
E
V
T
D
LVP-----------------
L
---
N
-----
G
D
E
R
------------------------
E
L
L
-
R
L
A
A
I
A
E
R
------------------------
R
S
E
H
P
I
A
E
A
I
V
---
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
-------------
D
G
---------
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
-------------
V
S
----
N
E
V
E
L
A
----
L
E
K
L
E
R
------
E
A
K
T
A
V
I
V
A
R
------------------------
N
G
------------------------
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
Y
N
V
I
L
I
P
-
A
A
------
A
G
-------
L
-------
L
Y
P
IFGVVF
R
--
P
E
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
P
P
I
R
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
86.82
46%
-99
- C1 -
3RFU
3
?
A:
[74-736]
--------------------------------------------------------------------------------------------------------------------------------------------------
V
S
P
E
Y
L
D
M
R
R
R
F
W
---
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
G
L
K
H
F
I
S
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
-
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
-
M
V
A
V
L
W
P
G
VFPHAFR
S
Q
E
G
V
V
A
----------
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
-
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
-
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
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L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
V
T
D
--------------------
D
---
F
-----
V
E
-
D
------------------------
N
A
L
-
A
L
A
A
A
L
E
H
------------------------
Q
S
E
H
P
L
A
N
A
I
V
---
H
A
A
K
E
K
G
L
S
L
-------
G
S
V
E
A
F
E
A
P
T
G
K
G
V
V
G
Q
---------
V
D
G
H
H
---------
V
A
I
G
N
A
R
L
M
Q
E
H
G
G
D
--------------
N
----
A
P
L
F
E
K
----
A
D
E
L
R
G
------
K
G
A
S
V
M
F
M
A
V
------------------------
D
G
------------------------
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
------
G
V
-------
L
YPLTGLL
L
--------
S
--
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
85.34
45%
-100
- C1 -
3RFU
3
?
B:
[84-736]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
G
L
K
H
F
I
S
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
-
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
-
V
L
W
----------
P
G
V
F
P
H
AFRSQEGVVA
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
-
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
-
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
KLTR
I
V
T
D
--------------------
D
---
F
-----
V
E
-
D
------------------------
N
A
L
-
A
L
A
A
A
L
E
H
------------------------
Q
S
E
H
P
L
A
N
A
I
V
---
H
A
A
K
E
K
G
L
S
L
-------
G
S
V
E
A
F
E
A
P
T
G
K
G
V
V
G
Q
---------
V
D
G
H
H
---------
V
A
I
G
N
A
R
L
M
Q
E
------------------------
H
G
G
D
N
----
A
P
L
F
E
K
ADELRG
K
G
A
S
V
M
F
M
A
V
------------------------
D
G
------------------------
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
GVLYPL
T
G
L------
L
-------
L
--------
S
--
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
85.30
45%
-100
- C1 -
3RFU
3
?
D:
[84-736]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
G
L
K
H
F
I
S
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
-
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
-
V
L
W
----------
P
G
V
F
P
H
AFRSQEGVVA
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
-
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
-
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
KLTR
I
V
T
D
--------------------
D
---
F
-----
V
E
-
D
------------------------
N
A
L
-
A
L
A
A
A
L
E
H
------------------------
Q
S
E
H
P
L
A
N
A
I
V
---
H
A
A
K
E
K
G
L
S
L
-------
G
S
V
E
A
F
E
A
P
T
G
K
G
V
V
G
Q
---------
V
D
G
H
H
---------
V
A
I
G
N
A
R
L
M
Q
E
------------------------
H
G
G
D
N
----
A
P
L
F
E
K
ADELRG
K
G
A
S
V
M
F
M
A
V
------------------------
D
G
------------------------
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
GVLYPL
T
G
L------
L
-------
L
--------
S
--
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
85.19
45%
-100
- C1 -
3RFU
3
?
C:
[84-736]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
G
L
K
H
F
I
S
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
-
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
-
V
L
W
----------
P
G
V
F
P
H
AFRSQEGVVA
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
-
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
-
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
KLTR
I
V
T
D
--------------------
D
---
F
-----
V
E
-
D
------------------------
N
A
L
-
A
L
A
A
A
L
E
H
------------------------
Q
S
E
H
P
L
A
N
A
I
V
---
H
A
A
K
E
K
G
L
S
L
-------
G
S
V
E
A
F
E
A
P
T
G
K
G
V
V
G
Q
---------
V
D
G
H
H
---------
V
A
I
G
N
A
R
L
M
Q
E
------------------------
H
G
G
D
N
----
A
P
L
F
E
K
ADELRG
K
G
A
S
V
M
F
M
A
V
------------------------
D
G
------------------------
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
GVLYPL
T
G
L------
L
-------
L
--------
S
--
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.18
45%
-100
- C1 -
3RFU
3
?
A:
[84-736]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
G
L
K
H
F
I
S
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
-
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
-
V
L
W
----------
P
G
V
F
P
H
AFRSQEGVVA
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
-
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
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S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
-
P
Q
P
A
L
S
Y
G
L
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A
A
V
S
V
L
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A
C
P
C
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L
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L
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T
P
M
S
I
M
V
G
V
G
K
G
A
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G
V
L
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N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
V
T
D
--------------------
D
---
F
-----
V
E
-
D
------------------------
N
A
L
-
A
L
A
A
A
L
E
H
------------------------
Q
S
E
H
P
L
A
N
A
I
V
---
H
A
A
K
E
K
G
L
S
L
-------
G
S
V
E
A
F
E
A
P
T
G
K
G
V
V
G
Q
---------
V
D
G
H
H
---------
V
A
I
G
N
A
R
L
M
Q
E
------------------------
H
G
G
D
N
----
A
P
L
F
E
K
A
D
E
L
R
G
K
G
A
S
V
M
F
M
A
V
------------------------
D
G
------------------------
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
GVLYPL
T
G
L------
L
-------
L
--------
S
--
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
85.03
45%
-100
- C1 -
4BYG
4
?
A:
[84-736]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
G
L
K
H
F
I
S
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
-
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
-
V
L
W
----------
P
G
V
F
P
H
AFRSQEGVVA
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
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Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
-
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
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R
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R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
-
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
V
T
D
--------------------
D
---
F
-----
V
E
-
D
------------------------
N
A
L
-
A
L
A
A
A
L
E
H
------------------------
Q
S
E
H
P
L
A
N
A
I
V
---
H
A
A
K
E
K
G
L
S
L
-------
G
S
V
E
A
F
E
A
P
T
G
K
G
V
V
G
Q
---------
V
D
G
H
H
---------
V
A
I
G
N
A
R
L
M
Q
E
------------------------
H
G
G
D
N
----
A
P
L
F
E
K
A
D
E
L
R
G
K
G
A
S
V
M
F
M
A
V
------------------------
D
G
------------------------
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
GVLYPL
T
G
L------
L
-------
L
--------
S
--
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.98
45%
-100
- C1 -
4BEV
2
?
A:
[84-736]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
G
L
K
H
F
I
S
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
-
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
-
V
L
W
----------
P
G
V
F
P
H
AFRSQEGVVA
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
-
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
-
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
V
T
D
--------------------
D
---
F
-----
V
E
-
D
------------------------
N
A
L
-
A
L
A
A
A
L
E
H
------------------------
Q
S
E
H
P
L
A
N
A
I
V
---
H
A
A
K
E
K
G
L
S
L
-------
G
S
V
E
A
F
E
A
P
T
G
K
G
V
V
G
Q
---------
V
D
G
H
H
---------
V
A
I
G
N
A
R
L
M
Q
E
------------------------
H
G
G
D
N
----
A
P
L
F
E
K
A
D
E
L
R
G
K
G
A
S
V
M
F
M
A
V
------------------------
D
G
------------------------
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
GVLYPL
T
G
L------
L
-------
L
--------
S
--
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
78.76
44%
-92
- C1 -
3J08
-
COPA_ARCFU
A:
[113-734]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
L
A
H
F
I
S
L
P
Y
E
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
R
T
L
-
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
A
-----------
G
V
L
P
R
E
Y
----------
S
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
-
V
V
I
R
-
D
G
K
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
-
S
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
W
Y
F
I
A
H
A
P
L
L
F
--
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
----
E
V
T
D
L
V
P
-----------------
L
---
N
-----
G
D
E
R
------------------------
E
L
L
-
R
L
A
A
I
A
E
R
------------------------
R
S
E
H
P
I
A
E
A
I
V
---
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
-------------
D
G
---------
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
-------------
V
S
----
N
E
V
E
L
A
----
L
E
K
L
E
R
------
E
A
K
T
A
V
I
V
A
R
------------------------
N
G
------------------------
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
Y
N
V
I
L
I
P
A
A
A
-------
G
-------
L
-------
L
Y
P
IFGVVF
R
--
P
E
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
P
P
I
R
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
78.72
44%
-92
- C1 -
3J08
-
COPA_ARCFU
A:
[97-735]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
K
R
K
L
Y
V
A
A
F
A
G
V
L
L
L
F
L
A
H
F
I
-------
S
L
P
Y
E
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
R
T
L
-
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
A
G
V
-----------
L
P
R
E
Y
----------
S
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
-
V
V
I
R
-
D
G
K
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
-
S
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
W
Y
F
I
A
-
H
-
A
P
L
L
F
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
----
E
V
T
D
--------------------
L
---
V
P
LNG-
D
E
-
R
------------------------
E
L
L
-
R
L
A
A
I
A
E
R
------------------------
R
S
E
H
P
I
A
E
A
I
V
---
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
-------------
D
G
---------
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
-------------
V
S
----
N
E
V
E
L
A
----
L
E
K
L
E
R
------
E
A
K
T
A
V
I
V
A
R
------------------------
N
G
------------------------
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
Y
N
V
I
L
I
P
A
A
A
------
G
L
L
Y
P
IFGV
V
-------
F
--------
R
--
P
E
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
P
P
I
R
R
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.81
32%
-94
- C1 -
4UMW
2
?
A:
[124-730]
----------------------------------------------------------------------------------------------------------------------------------------------------
R
L
K
E
N
L
--
P
L
I
T
L
I
V
M
M
A
I
S
W
G
L
E
Q
--
F
N
H
P
F
G
Q
----------
L
A
F
I
A
T
T
L
V
G
L
---
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
-----------------
G
A
T
A
E
-----------------
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
----
V
S
A
L
M
A
L
K
P
E
T
A
-
T
R
L
R
-
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
P
P
L
L
F
-
A
-
A
S
W
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
----
R
V
T
A
--------------------
I
---
H
P
A
TGI
S
E
-
S
------------------------
E
L
L
-
T
L
A
A
A
V
E
Q
------------------------
G
A
T
H
P
L
A
Q
A
I
V
---
R
E
A
Q
V
A
E
L
A
I
-------
P
T
A
E
S
Q
R
A
L
V
G
S
G
I
E
A
Q
---------
V
N
G
E
R
---------
V
L
I
----------
C
A
-------------
A
G
----
K
H
P
A
D
A
F
A
G
L
I
N
E
L
E
S
------
A
G
Q
T
V
V
L
V
V
R
------------------------
N
D
------------------------
D
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
-----------------------------------------------------
E
------------------------------------------------------
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
A
-
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
L
------
L
G
-------
M
-------
T
--------
G
--
L
W
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Fugue
72.19
33%
-75
- C1 -
4UMW
2
?
A:
[124-730]
------------------------
R
L
K
E
N
L
P
L
I
T
L
I
V
M
M
A
I
S
W
G
L
E
Q
F
N
---------------------------------------------------
H
P
F
G
Q
L
A
F
I
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
----------------------------------------------------------------------------------
G
S
Y
F
A
--------
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
----------------------------------
A
T
A
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
V
----
S
A
L
M
A
L
K
P
E
T
A
-
T
R
L
R
-
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
P
P
L
L
F
-
A
A
-
S
W
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
----
R
V
T
A
--------------------
I
---
H
P
A
TGI
S
E
-
S
------------------------
E
L
L
-
T
L
A
A
A
V
E
Q
------------------------
G
A
T
H
P
L
A
Q
A
I
V
---
R
E
A
Q
V
A
E
L
A
I
-------
P
T
A
E
S
Q
R
A
L
V
G
S
G
I
E
A
Q
---------
V
N
G
E
R
---------
V
L
I
C
A
------
A
G
K
H
-------------
P
A
----
D
A
F
A
G
L
----
I
N
E
L
E
S
------
A
G
Q
T
V
V
L
V
V
R
------------------------
N
D
------------------------
D
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
------------------------------------------------------
E
-----------------------------------------------------
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
-
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
L
------
L
G
-------
M
-------
T
--------
G
--
L
W
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
71.45
32%
-87
- C1 -
4UMV
2
?
A:
[126-730]
------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
N
L
--
P
L
I
T
L
I
V
M
M
A
I
S
W
G
L
E
Q
--
F
N
H
P
F
G
Q
----------
L
A
F
I
A
T
T
L
V
G
L
---
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
-----------------
G
A
T
A
E
-----------------
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
A
R
Q
G
V
S
A
L
M
A
L
K
P
E
T
A
-
T
R
L
R
-
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
P
P
L
L
F
-
A
-
A
S
W
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
----
R
V
T
A
--------------------
I
---
H
P
A
TGI
S
E
-
S
------------------------
E
L
L
-
T
L
A
A
A
V
E
Q
------------------------
G
A
T
H
P
L
A
Q
A
I
V
---
R
E
A
Q
V
A
E
L
A
I
-------
P
T
A
E
S
Q
R
A
L
V
G
S
G
I
E
A
Q
---------
V
N
G
E
R
---------
V
L
I
----------
C
A
-------------
A
G
----
K
H
P
A
D
A
F
A
G
L
I
N
E
L
E
S
------
A
G
Q
T
V
V
L
V
V
R
------------------------
N
D
------------------------
D
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
-----------------------------------------------------
E
------------------------------------------------------
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
A
-
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
L
------
L
G
-------
M
-------
T
--------
G
--
L
W
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Fugue
65.68
23%
-67
- C1 -
3B8E
6
AT1A1_PIG
A:
[1-998]
--------------------
A
K
K
E
R
D
M
D
---------
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
R
K
Y
G
T
D
L
S
R
G
L
------------------------------------------------------
T
P
A
R
A
A
E
I
L
A
R
D
G
P
N
A
L
T
P
P
P
T
T
P
E
W
V
K
F
C
R
Q
L
F
G
G
F
S
M
L
L
W
I
G
A
I
L
-----------------------------------------------------------------------
C
F
L
A
Y
G
I
Q
A
A
-------
T
E
E
E
P
Q
N
----------
D
N
L
Y
L
G
V
V
L
S
A
V
V
I
I
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
K
I
M
E
S
F
K
N
M
V
P
Q
Q
A
-
L
V
I
R
-
N
G
E
K
M
S
I
N
A
E
E
V
V
V
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
A
N
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
D
----------
F
T
N
ENPLETRNI
A
F
F
S
T
N
C
V
E
G
T
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
G
G
Q
T
P
I
A
A
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
--
L
S
L
I
-
L
E
Y
T
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
----
T
V
A
H
MWSDN
Q
I
H
E
A
DTTENQSGVS
F
---
D
-----
K
T
-
S
------------------------
A
T
W
-
L
A
L
S
R
I
A
G
LCNR
A
V
F
Q
A
NQENLPILK
R
A
V
A
GD
A
S
E
S
A
L
L
K
C
I
E
L
CC
G
S
V
K
E
M
R
E
R
Y
-------
T
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
---------
I
H
K
N
P
NTAEPR
H
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
S
I
L
I
HGKEQPLDEE
L
K
----
D
A
F
Q
N
A
----
Y
L
E
L
G
G
------
L
G
E
R
V
L
G
F
C
H
------------------------
L
F
L
P
DEQFPEGF
Q
F
D
T
DDVNFPLDN
L
C
F
V
G
L
I
S
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGN
E
T
V
E
D
IAARLNIPVSQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
MT
S
E
Q
L
D
D
I
L
K
YHT
E
I
-----------------------------------------------------
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
S
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
------
I
F
-------
I
-------
I
--------
A
NI
P
L
P
L
G
T
V
T
I
L
C
-
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
S
D
I
MKRQPRNPKTDKLVN
E
Q
L
I
S
M
A
YGQ
I
G
M
I
Q
A
L
G
G
F
F
T
Y
F
V
I
L
A
E
N
GFLPIHLL
G
L
R
V
N
WDDRWINDVEDSYG
Q
Q
W
T
Y
EQRKIVEFT
C
H
T
P
F
F
V
T
I
V
V
V
Q
W
A
D
L
V
I
C
KTRRNSVFQQGMKN
K
I
L
I
F
G
L
F
E
E
T
A
L
A
A
F
L
S
Y
CPGMGVA
L
R
M
Y
P
LKPTWWFCAFPY
S
L
L
I
F
V
Y
D
E
V
R
K
L
I
I
R
R
RPGGW
V
E
K
E
T
YY
43
HHSearch
64.39
25%
-74
- C1 -
2ZXE
5
?
A:
[136-793]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
-
L
V
I
R
-
D
G
E
K
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
A
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
FSSENPLETR
N
I
----------
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
G
-
Y
--
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
----
T
V
A
H
--------------------
M
---
W
-----
F
D
-
N
Q
I
H
E
A
DTTENQSGAAFDKTS
A
T
W
S
A
L
S
-
R
I
A
A
L
C
N
R
A
V
F
Q
A
GQDNVPILKRS--------
V
A
G
D
A
S
E
S
A
L
L
---
K
C
I
E
L
C
C
G
S
V
Q
G
M
R
D
R
N
P
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
ENEKSSE
S
R
Y
L
L
---------
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
ILLNG
A
E
E
P
----
L
K
E
D
M
K
E
A
F
Q
N
A
----
Y
L
E
L
G
G
------
L
G
E
R
V
L
G
F
C
H
F
ALPEDKYNEG
Y
P
F
D
ADEPNFPTT
D
L
------------------------
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
-----------------------------------------------------
I
S
EGNET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
L
H
Y
H
T
E
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
57.25
43%
-84
- C1 -
3A1C
1
?
B:
[14-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
----
E
V
T
D
--------------------
L
VPL
N
-----
G
D
-
E
------------------------
R
E
L
L
R
L
A
A
I
A
E
R
------------------------
R
S
E
H
P
I
A
E
A
I
V
---
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
-------------
D
G
---------
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
-------------
V
S
----
N
E
V
E
L
A
----
L
E
K
L
E
R
------
E
A
K
T
A
V
I
V
A
R
------------------------
N
G
------------------------
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
56.87
43%
-83
- C1 -
3A1D
2
?
B:
[13-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
----
E
V
T
D
--------------------
L
V
P
L
N
-----
G
D
-
E
------------------------
R
E
L
L
R
L
A
A
I
A
E
R
------------------------
R
S
E
H
P
I
A
E
A
I
V
---
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
-------------
D
G
---------
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
-------------
V
S
----
N
E
V
E
L
A
----
L
E
K
L
E
R
------
E
A
K
T
A
V
I
V
A
R
------------------------
N
G
------------------------
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
56.32
43%
-83
- C1 -
3A1D
2
?
A:
[14-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
----
E
V
T
D
--------------------
L
V
P
L
N
-----
G
D
-
E
------------------------
R
E
L
L
R
L
A
A
I
A
E
R
------------------------
R
S
E
H
P
I
A
E
A
I
V
---
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
-------------
D
G
---------
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
-------------
V
S
----
N
E
V
E
L
A
----
L
E
K
L
E
R
------
E
A
K
T
A
V
I
V
A
R
------------------------
N
G
------------------------
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
56.29
44%
-81
- C1 -
3A1C
2
?
A:
[14-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
----
E
V
T
D
--------------------
L
---
V
P
LNG-
D
E
-
R
------------------------
E
L
L
-
R
L
A
A
I
A
E
R
------------------------
R
S
E
H
P
I
A
E
A
I
V
---
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
-------------
D
G
---------
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
-------------
V
S
----
N
E
V
E
L
A
----
L
E
K
L
E
R
------
E
A
K
T
A
V
I
V
A
R
------------------------
N
G
------------------------
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
56.02
42%
-84
- C1 -
3A1E
1
B:
[13-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
----
E
V
T
D
--------------------
L
V
P
L
N
-----
G
D
-
E
------------------------
R
E
L
L
R
L
A
A
I
A
E
R
------------------------
R
S
E
Q
P
I
A
E
A
I
V
---
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
-------------
D
G
---------
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
-------------
V
S
----
N
E
V
E
L
A
----
L
E
K
L
E
R
------
E
A
K
T
A
V
I
V
A
R
------------------------
N
G
------------------------
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
55.98
43%
-81
- C1 -
3A1C
2
?
A:
[14-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
----
E
V
T
D
--------------------
L
V
P
L
N
-----
G
D
-
E
------------------------
R
E
L
L
R
L
A
A
I
A
E
R
------------------------
R
S
E
H
P
I
A
E
A
I
V
---
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
-------------
D
G
---------
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
-------------
V
S
----
N
E
V
E
L
A
----
L
E
K
L
E
R
------
E
A
K
T
A
V
I
V
A
R
------------------------
N
G
------------------------
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
55.94
42%
-81
- C1 -
3A1E
2
COPA_ARCFU
A:
[14-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
----
E
V
T
D
--------------------
L
V
P
L
N
-----
G
D
-
E
------------------------
R
E
L
L
R
L
A
A
I
A
E
R
------------------------
R
S
E
Q
P
I
A
E
A
I
V
---
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
-------------
D
G
---------
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
-------------
V
S
----
N
E
V
E
L
A
----
L
E
K
L
E
R
------
E
A
K
T
A
V
I
V
A
R
------------------------
N
G
------------------------
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
43.59
33%
-62
- C1 -
2YJ6
2
?
B:
[13-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
T
P
----
I
V
T
Q
--------------------
F
---
I
-----
G
D
-
S
------------------------
L
S
L
-
A
Y
A
A
S
V
E
A
------------------------
L
S
S
H
P
I
A
K
A
I
V
---
K
Y
A
K
E
Q
G
V
K
I
-------
L
E
V
K
D
F
K
E
I
S
G
I
G
V
R
G
K
---------
I
S
D
K
I
---------
I
E
V
--
K
K
A
E
N
N
N
D
I
A
------------------------------------------------
V
Y
I
------------------------
N
G
------------------------
E
P
I
A
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------------------
Q
E
-----------------------------------------------------
Y
Y
S
N
L
S
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
G
V
D
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
42.90
33%
-62
- C1 -
2YJ6
1
?
A:
[13-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
T
P
----
I
V
T
Q
--------------------
F
---
I
-----
G
D
-
S
------------------------
L
S
L
-
A
Y
A
A
S
V
E
A
------------------------
L
S
S
H
P
I
A
K
A
I
V
---
K
Y
A
K
E
Q
G
V
K
I
-------
L
E
V
K
D
F
K
E
I
S
G
I
G
V
R
G
K
---------
I
S
D
K
I
---------
I
E
V
--
K
K
A
E
N
N
N
D
I
A
------------------------------------------------
V
Y
I
------------------------
N
G
------------------------
E
P
I
A
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------------------
Q
E
-----------------------------------------------------
Y
Y
S
N
L
S
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
---
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
42.60
33%
-61
- C1 -
2YJ5
1
?
B:
[13-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
T
P
----
I
V
T
Q
--------------------
F
---
I
-----
G
D
-
S
------------------------
L
S
L
-
A
Y
A
A
S
V
E
A
------------------------
L
S
S
H
P
I
A
K
A
I
V
---
K
Y
A
K
E
Q
G
V
K
I
-------
L
E
V
K
D
F
K
E
I
S
G
I
G
V
R
G
K
---------
I
S
D
K
I
---------
I
E
V
--
K
K
A
E
N
N
N
D
I
A
------------------------------------------------
V
Y
I
------------------------
N
G
------------------------
E
P
I
A
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------------------
Q
E
-----------------------------------------------------
Y
Y
S
N
L
S
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
G
V
D
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------