@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2402: (2016-04-03 )
MYERKLVMQKSALFAPEKYNIISEIEKYSHIPDKKAILYHNTEGEDISVTYQQLIEQSNKVGNVLASHGLSKGDKVLIMMPRSIATYELYIAALKLGVAIIPCSEMLRTKDLQYRITHGEINAVIALEPFTVEFEKIKEYDALTKFVIAGQKDGWISLEAEKENASNKLEMADTTRDDMAILSYTSGTTGNPKAVTHCHGWGFAHLQMAPKHWLCINEDDLVWATAAPGWQKWVWSPFLSVLGSGATAFVFNGRFSPETYLELLQKYQINVLCCTPTEYRMMAKLQNLNDYDLTHLHSAVSAGEPLNREVVEQFKKYFNLTVRDGYGQTESTLLIGFLKDTPQRIGSMGKGIPGSSVTVVDDEGNSVPANTKGNIAVPLDLPALFKGYYKEPERTAKAQTGKYYITGDLAHVDDDGYFWFEGRRDDIIISSGYTIGPFEVEDALTNHPAVKECAVVAKPHDIRGNIVKAFVILQDHTAGDDTLVKELQQFVKNEVAPYKYPREIEFVDDLPKTNSGKIRRVELRDSEIEKWQQQKDSNQ
Atome Classification :
(20 SA)
.........10........20.---...-------.----...30.........40.......----.50........60.....-...70........80........90........100.......110.......120.......130-......---..-140--..------.-------..--------....150-.--..-----------.....160...----....170---........180.......190.......200.......210---.......220.......230.......240.......250-.-.---......260.......270.......280.........290.......300.......310.......---320.......330----........340.......350.......360.......370.....------..---380-.........390.......400.---......410.......420.......430.......440.......450.......460.......470......--.480-........490.......500.......510.......520.......530.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MY
E
R
K
L
V
M
Q
K
SALFAP
E
K
Y
N
I
I
---
S
E
I
-------
E
----
K
Y
SH-IPDK
K
A
I
L
Y
HNTEGE
D
I
S
----
V
T
Y
Q
Q
L
I
E
QSNK
V
G
N
V
L
A
-SHGLSKG
D
K
V
L
I
M
MPRSI
A
T
Y
E
L
Y
I
A
A
L
K
L
G
V
A
I
I
P
C
S
E
M
L
RTKD
L
Q
Y
R
I
THG
E
I
N
A
V
I
A
LEP
F
T
--
V
E
F
E
K
I
---
K
E
-
Y
----
D
A
------
L
-------
T
K
--------
F
V
I
AGQ--K--D
G
-----------
W
I
S
L
E
AEKENA----SNK
L
E
M----ADTTRD
D
M
A
I
L
S
YTSGTTGNP
K
A
V
T
HCHGWG
F
A
H
LQMAPK
H
---
W
L
C
INED
D
L
V
W
A
TAAPG
W
Q
K
W
V
W
S
P
F
L
S
V
LGSG
A
T
A
F
V
-F-N-G---RF
S
P
E
T
Y
L
E
L
L
Q
KYQ
I
N
V
L
C
CT
P
T
E
Y
R
--
M
M
A
K
LQNLNDY
D
L
T
H
L
H
S
A
VSAGEPL
N
R
E
V
V
E
Q
F
K
K
YF
N
---
L
T
V
RDGYGQTE
S
-----
T
L
L
I
G
F
L
KD
T
P
Q
R
I
G
S
MGKGIPGS
S
V
T
V
VDDEGNSVPANTKG
N
I
A
V
------PL---D---
L
P
A
L
F
K
G
Y
YKEP
E
R
TAKAQTG
K
Y
---
Y
I
TGDLAHVDDDG
Y
F
W
F
EGRRD
D
I
I
ISSG
Y
T
IG
P
F
E
V
E
D
ALTNHP
A
V
K
E
C
A
V
VAKPHDIRG
N
I
V
K
A
F
V
I
L
QDHTA--G
D
D
--
T
L
V
K
E
L
Q
Q
F
V
KNEVAPYKYPREI
E
F
V
DDLPKTNSG
K
I
R
R
V
E
LR
D
S
E
I
E
K
W
Q
Q
QKDSNQ
21
PsiBlast_CBE
96.01
36%
-101
- C5 -
3ETC
10
?
B:
[49-562]
------------
I
L
V
P
E
N
F
N
F
A
---
Y
D
V
V
------
D
----
V
Y
A
R
D
S
P
E
K
L
A
M
I
W
C
D
D
Y
G
N
E
K
I
----
F
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
-
K
H
G
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
I
A
E
D
D
--
V
P
-
E
Q
V
---
D
E
-
A
----
H
A
E
C
GDIP
L
-------
K
K
--------
A
K
V
G
G
D
--
V
L-
E
G
-----------
W
I
D
F
R
K
E
L
E
E
S
----
S
P
I
F
E
R
PTGE
V
S
T
K
N
E
D
I
C
L
V
Y
F
S
S
G
T
A
G
F
P
K
M
V
E
H
D
N
T
Y
P
L
G
H
I
L
T
A
-
K
Y
---
W
Q
N
V
E
D
D
G
L
H
Y
T
V
A
D
S
G
W
G
K
C
V
W
G
K
L
Y
G
Q
W
I
A
G
C
A
V
F
V
-
Y
-
D
Y
D
---
R
F
E
A
K
N
M
L
E
K
A
S
K
Y
G
V
T
T
F
C
A
P
P
T
I
Y
R
--
F
L
I
K
-
E
D
L
S
H
Y
N
F
S
T
L
K
Y
A
V
V
A
G
E
P
L
N
P
E
V
F
N
R
F
L
E
F
T
G
---
I
K
L
M
E
G
F
G
Q
T
E
T
-----
V
V
T
I
A
T
F
P
W
M
E
P
K
P
G
S
I
G
K
P
T
P
G
Y
K
I
E
L
M
D
R
D
G
R
L
C
E
V
G
E
E
G
E
I
V
I
NTMEGK
P
V
---------
G
L
F
V
H
Y
G
K
D
P
E
R
T
E
E
T
W
H
D
G
Y
---
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
I
Q
H
P
A
V
L
E
C
A
I
T
G
V
P
D
P
V
R
G
Q
V
I
K
A
T
I
V
L
T
K
D
Y
T
--
P
S
D
--
S
L
K
N
E
L
Q
D
H
V
K
N
V
T
A
P
Y
K
Y
P
R
I
I
E
F
V
P
E
L
P
K
---------------------------
1
PsiBlast_PDB
95.52
36%
-102
- C5 -
3ETC
11
?
A:
[49-559]
------------
I
L
V
P
E
N
F
N
F
A
---
Y
D
V
V
------
D
----
V
Y
A
R
D
S
P
E
K
L
A
M
I
W
C
D
D
Y
G
N
E
K
I
----
F
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
-
K
H
G
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
I
A
E
D
D
--
V
P
-
E
Q
V
---
D
E
-
A
----
H
A
E
C
GDIP
L
-------
K
K
--------
A
K
V
G
G
D
--
V
L-
E
G
-----------
W
I
D
F
R
K
E
L
E
E
S
----
S
P
I
F
E
R
PTGE
V
S
T
K
N
E
D
I
C
L
V
Y
F
S
S
G
T
A
G
F
P
K
M
V
E
H
D
N
T
Y
P
L
G
H
I
L
T
A
-
K
Y
---
W
Q
N
V
E
D
D
G
L
H
Y
T
V
A
D
S
G
W
G
K
C
V
W
G
K
L
Y
G
Q
W
I
A
G
C
A
V
F
V
-
Y
-
D
Y
D
---
R
F
E
A
K
N
M
L
E
K
A
S
K
Y
G
V
T
T
F
C
A
P
P
T
I
Y
R
--
F
L
I
K
-
E
D
L
---
N
F
S
T
L
K
Y
A
V
V
A
G
E
P
L
N
P
E
V
F
N
R
F
L
E
F
T
G
---
I
K
L
M
E
G
F
G
Q
T
E
T
-----
V
V
T
I
A
T
F
P
W
M
E
P
K
P
G
S
I
G
K
P
T
P
G
Y
K
I
E
L
M
D
R
D
G
R
L
C
E
V
G
E
E
G
E
I
V
I
NTMEGK
P
V
---------
G
L
F
V
H
Y
G
K
D
P
E
R
T
E
E
T
W
H
D
G
Y
---
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
I
Q
H
P
A
V
L
E
C
A
I
T
G
V
P
D
P
V
R
G
Q
V
I
K
A
T
I
V
L
T
K
D
Y
T
--
P
S
D
--
S
L
K
N
E
L
Q
D
H
V
K
N
V
T
A
P
Y
K
Y
P
R
I
I
E
F
V
P
E
------------------------------
31
HHSearch
95.18
34%
-96
- C5 -
3C5E
7
ACS2A_HUMAN
A:
[30-562]
-----------
H
Q
E
V
P
A
K
F
N
F
A
SDV
L
D
H
-------
W
A
D
M
E
K
A
G
K
-
R
P
P
S
P
A
L
W
W
V
N
G
K
G
K
E
L
M
----
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
I
--
Q
E
V
D
T
V
---
A
S
E
C
----
P
S
------
L
-------
R
I
--------
K
L
L
V
S
E
K
S
C
--
D
G
-----------
W
L
N
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
L
G
L
K
A
K
M
D
-
A
G
---
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
-
H
L
L
-
P
---
K
F
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
--
M
L
L
Q
Q
D
-
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
------
R
V
KP
I
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
SH
D
P
E
--
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
----------
5
PsiBlast_PDB
94.59
33%
-93
- C5 -
3DAY
19
ACS2A_HUMAN
A:
[26-560]
-------
L
Q
W
G
H
Q
E
V
P
A
K
F
N
F
A
---
S
D
V
L
D
H
W
A
D
M
E
----
K
A
G
K
-
R
P
P
S
P
A
L
W
W
V
N
G
K
G
K
E
L
M
----
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
I
--
Q
E
V
D
T
V
A--
S
E
-
C
----
P
S
------
L
-------
R
I
--------
K
L
L
V
S
E
--
K
S
C
D
G
-----------
W
L
N
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
D
AG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
F
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
--
M
L
L
Q
-
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
RVK---
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
--
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
------------
4
PsiBlast_PDB
93.76
33%
-94
- C5 -
3C5E
7
ACS2A_HUMAN
A:
[27-560]
--------
Q
W
G
H
Q
E
V
P
A
K
F
N
F
A
---
S
D
V
L
D
H
W
A
D
M
E
----
K
A
G
K
-
R
P
P
S
P
A
L
W
W
V
N
G
K
G
K
E
L
M
----
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
I
--
Q
E
V
D
T
V
A--
S
E
-
C
----
P
S
------
L
-------
R
I
--------
K
L
L
V
S
E
--
K
S
C
D
G
-----------
W
L
N
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
D
AG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
F
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
--
M
L
L
Q
-
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
VK---
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
------------
23
PsiBlast_CBE
93.61
33%
-91
- C5 -
2WD9
2
ACS2A_HUMAN
B:
[30-560]
-----------
H
Q
E
V
P
A
K
F
N
F
A
---
S
D
V
L
D
H
W
A
D
M
E
----
K
A
G
K
-
R
P
P
S
P
A
L
W
W
V
N
G
K
G
K
E
L
M
----
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
I
--
Q
E
V
D
T
V
A--
S
E
-
C
----
P
S
------
L
-------
R
I
--------
K
L
L
V
S
E
--
K
S
C
D
G
-----------
W
L
N
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
D
AG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
F
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
--
M
L
L
Q
-
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
VK---
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
------------
22
PsiBlast_CBE
93.21
33%
-89
- C5 -
2WD9
2
ACS2A_HUMAN
C:
[27-560]
--------
Q
W
G
H
Q
E
V
P
A
K
F
N
F
A
---
S
D
V
LDHWADM
E
----
K
A
G
K
-
R
P
P
S
P
A
L
W
W
V
N
G
K
G
K
E
L
M
----
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
I
--
Q
E
V
D
T
V
A--
S
E
-
C
----
P
S
------
L
-------
R
I
--------
K
L
L
V
S
E
--
K
SC
D
G
-----------
W
L
N
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
DAG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
F
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
--
M
L
L
Q
-
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
RVK---
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
PE
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
------------
7
PsiBlast_PDB
93.12
33%
-91
- C5 -
3EQ6
2
ACS2A_HUMAN
A:
[30-560]
-----------
H
Q
E
V
P
A
K
F
N
F
A
---
S
D
V
L
D
H
W
A
D
M
E
----
K
A
G
K
-
R
P
P
S
P
A
L
W
W
V
N
G
K
G
K
E
L
M
----
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
I
--
Q
E
V
D
T
V
A--
S
E
-
C
----
P
S
------
L
-------
R
I
--------
K
L
L
V
S
E
--
K
S
C
D
G
-----------
W
L
N
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
D
AG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
F
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
--
M
L
L
Q
-
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
RVK---
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
------------
2
PsiBlast_PDB
92.98
33%
-90
- C5 -
2WD9
1
ACS2A_HUMAN
A:
[30-560]
-----------
H
Q
E
V
P
A
K
F
N
F
A
---
S
D
V
L
D
H
W
A
D
M
E
----
K
A
G
K
-
R
P
P
S
P
A
L
W
W
V
N
G
K
G
K
E
L
M
----
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
I
--
Q
E
V
D
T
V
A--
S
E
-
C
----
P
S
------
L
-------
R
I
--------
K
L
L
V
S
E
--
K
S
C
D
G
-----------
W
L
N
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
D
AG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
F
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
--
M
L
L
Q
-
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
VK---
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
------------
6
PsiBlast_PDB
92.96
33%
-91
- C5 -
2VZE
1
ACS2A_HUMAN
A:
[30-560]
-----------
H
Q
E
V
P
A
K
F
N
F
A
---
S
D
V
L
D
H
W
A
D
M
E
----
K
A
G
K
-
R
P
P
S
P
A
L
W
W
V
N
G
K
G
K
E
L
M
----
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
I
--
Q
E
V
D
T
V
A--
S
E
-
C
----
P
S
------
L
-------
R
I
--------
K
L
L
V
S
E
--
K
S
C
D
G
-----------
W
L
N
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
D
AG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
F
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
--
M
L
L
Q
-
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
VK---
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
------------
25
PsiBlast_CBE
92.92
33%
-91
- C5 -
3EQ6
2
ACS2A_HUMAN
B:
[30-560]
-----------
H
Q
E
V
P
A
K
F
N
F
A
---
S
D
V
LDHWADM
E
----
K
A
G
K
-
R
P
P
S
P
A
L
W
W
V
N
G
K
G
K
E
L
M
----
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
I
--
Q
E
V
D
T
V
A--
S
E
-
C
----
P
S
------
L
-------
R
I
--------
K
L
L
V
S
E
--
K
SC
D
G
-----------
W
L
N
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
DAG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
F
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
--
M
L
L
Q
-
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
RVK---
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
PE
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
------------
30
HHSearch
92.79
37%
-100
- C5 -
3ETC
11
?
A:
[65-559]
----------------------------------------
Y
A
R
D
-
S
P
E
K
L
A
M
I
W
C
D
D
Y
G
N
E
K
I
----
F
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
-
K
H
G
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
I
A
E
D
D
V
P
E
Q
V
D
E
A
---
H
A
E
C
----
G
D
IP----
L
-------
K
K
--------
A
K
V
G
G
D
V-
L
--
E
G
-----------
W
I
D
F
R
K
E
L
E
E
S
SPIF
E
R
P
T
G
E
----
V
S
T
K
N
E
D
I
C
L
V
Y
F
S
S
G
T
A
G
F
P
K
M
V
E
H
D
N
T
Y
P
L
G
H
I
L
T
A
-
K
Y
---
W
Q
N
V
E
D
D
G
L
H
Y
T
V
A
D
S
G
W
G
K
C
V
W
G
K
L
Y
G
Q
W
I
A
G
C
A
V
F
V
-
Y
-
D
Y
D
---
R
F
E
A
K
N
M
L
E
K
A
S
K
Y
G
V
T
T
F
C
A
P
P
T
I
Y
R
--
F
L
I
K
E
D
-
L
---
N
F
S
T
L
K
Y
A
V
V
A
G
E
P
L
N
P
E
V
F
N
R
F
L
E
F
T
G
---
I
K
L
M
E
G
F
G
Q
T
E
T
-----
V
V
T
I
A
T
F
P
W
M
E
P
K
P
G
S
I
G
K
P
T
P
G
Y
K
I
E
L
M
D
R
D
G
R
L
C
E
V
G
E
E
G
E
I
V
I
------
N
T
---
M
EGK
P
V
G
L
F
V
H
Y
G
K
D
P
E
R
T
E
E
T
W
H
D
G
Y
---
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
I
Q
H
P
A
V
L
E
C
A
I
T
G
V
P
D
P
V
R
G
Q
V
I
K
A
T
I
V
L
T
K
D
Y
T
--
P
S
D
--
S
L
K
N
E
L
Q
D
H
V
K
N
V
T
A
P
Y
K
Y
P
R
I
I
E
F
V
P
E
------------------------------
3
PsiBlast_PDB
92.67
33%
-88
- C5 -
3B7W
6
ACS2A_HUMAN
A:
[26-560]
-------
L
Q
W
G
H
Q
E
V
P
A
K
F
N
F
A
---
S
D
V
L
D
H
W
A
D
M
E
----
K
A
G
K
-
R
P
P
S
P
A
L
W
W
V
N
G
K
G
K
E
L
M
----
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
I
--
Q
E
V
D
T
V
A--
S
E
-
C
----
P
S
------
L
-------
R
I
--------
K
L
L
V
S
E
--
K
S
C
D
G
-----------
W
L
N
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
D
AG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
F
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
--
M
L
L
Q
-
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
RVK---
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
------------
8
PsiBlast_PDB
92.58
33%
-96
- C5 -
3GPC
2
ACS2A_HUMAN
A:
[29-560]
----------
G
H
Q
E
V
P
A
K
F
N
F
A
---
S
D
V
L
D
H
W
A
D
M
E
----
K
A
G
K
-
R
P
P
S
P
A
L
W
W
V
N
G
K
G
K
E
L
M
----
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
I
--
Q
E
V
D
T
V
A--
S
E
-
C
----
P
S
------
L
-------
R
I
--------
K
L
L
V
S
E
--
K
S
C
D
G
-----------
W
L
N
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
--
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
D
AG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
F
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
--
M
L
L
Q
-
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
RVK---
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
------------
27
PsiBlast_CBE
92.06
33%
-91
- C5 -
2VZE
1
ACS2A_HUMAN
B:
[30-560]
-----------
H
Q
E
V
P
A
K
F
N
F
A
---
S
D
V
L
D
H
W
A
D
M
E
----
K
A
G
K
-
R
P
P
S
P
A
L
W
W
V
N
G
K
G
K
E
L
M
----
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
I
--
Q
E
V
D
T
V
A--
S
E
-
C
----
P
S
------
L
-------
R
I
--------
K
L
L
V
S
E
--
K
S
C
D
G
-----------
W
L
N
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
D
AG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
F
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
--
M
L
L
Q
-
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
RVK---
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
------------
26
PsiBlast_CBE
92.05
33%
-89
- C5 -
2VZE
2
ACS2A_HUMAN
C:
[27-560]
--------
Q
W
G
H
Q
E
V
P
A
K
F
N
F
A
---
S
D
V
LDHWADM
E
----
K
A
G
K
-
R
P
P
S
P
A
L
W
W
V
N
G
K
G
K
E
L
M
----
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
I
--
Q
E
V
D
T
V
A--
S
E
-
C
----
P
S
------
L
-------
R
I
--------
K
L
L
V
S
E
--
K
SC
D
G
-----------
W
L
N
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
DAG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
F
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
--
M
L
L
Q
-
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
RVK---
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
PE
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
------------
24
PsiBlast_CBE
91.64
33%
-94
- C5 -
3GPC
2
ACS2A_HUMAN
B:
[28-560]
---------
W
G
H
Q
E
V
P
A
K
F
N
F
A
---
S
D
V
L
D
H
W
A
D
M
E
----
K
A
G
K
-
R
P
P
S
P
A
L
W
W
V
N
G
K
G
K
E
L
M
----
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
I
--
Q
E
V
D
T
V
A--
S
E
-
C
----
P
S
------
L
-------
R
I
--------
K
L
L
V
S
E
--
K
S
C
D
G
-----------
W
L
N
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
----
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
---
G
L
P
K
M
A
E
H
----
S
Y
S
S
L
G
L
K
A
K
M
D
AG
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
F
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
--
M
L
L
Q
-
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
RVK---
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
------------
15
PsiBlast_PDB
82.58
29%
-78
- C5 -
2P2F
3
ACSA_SALTY
A:
[91-621]
-----------------------------------------------
D
R
T
A
I
I
W
---
E
G
D
D
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
A
D
E
G
V
--
R
A
G
R
S
I
---
P
L
-
K
K
N
V
D
D
A
------
L
K
NPNVTS
V
E
--------
H
V
I
V
L
K
--
R
--
T
G
SD
I
D
W
Q
E
GRDL
W
W
R
D
L
I
E
K
A
S
P
----
E
H
Q
P
E
-----
A
M
N
A
E
D
P
L
F
I
L
-
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
Y
L
V
Y
A
A
T
T
F
K
Y
---
V
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
-
F
-
E
-
G
VPN
W
P
T
P
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
I
E
G
T
D
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
G
KEK
C
P
V
V
D
T
W
W
Q
T
E
T
GGFM
I
T
P
L
P
G
A
I
E
---
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
A
T
E
G
N
L
V
I
------
T
D
---
S
---
W
P
G
Q
A
R
T
L
F
G
D
H
E
R
F
E
Q
T
Y
F
S
T
F
KNM
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
--
P
S
P
--
E
L
Y
A
E
V
R
N
W
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
---------------
11
PsiBlast_PDB
82.29
29%
-79
- C5 -
2P2B
2
ACSA_SALTY
A:
[91-626]
-----------------------------------------------
D
R
T
A
I
I
W
---
E
G
D
D
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
A
D
E
G
V
--
R
A
G
R
S
I
P
L
K
K
N
-
V
----
D
D
------
A
-------
L
K
NPNVTSVE
H
V
I
V
L
K
--
R
--
T
G
S
D
I
D
W
Q
E
GRDL
W
W
R
D
L
I
E
K
A
S
P
----
E
H
Q
P
E
-----
A
M
N
A
E
D
P
L
F
I
L
-
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
Y
L
V
Y
A
A
T
T
F
K
Y
---
V
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
-
F
-
E
-
G
VPN
W
P
T
P
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
I
E
G
T
D
R
S
S
L
R
I
L
G
S
A
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
G
KEK
C
P
V
V
D
T
W
W
Q
T
E
T
GGFM
I
T
P
L
P
G
A
I
E
---
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
A
T
E
G
N
L
V
I
------
T
D
---
S
---
W
P
G
Q
A
R
T
L
F
G
D
H
E
R
F
E
Q
T
Y
F
S
T
F
KNM
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
--
P
S
P
--
E
L
Y
A
E
V
R
N
W
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
---------------
17
PsiBlast_PDB
82.26
29%
-81
- C5 -
2P20
1
ACSA_SALTY
A:
[91-618]
-----------------------------------------------
D
R
T
A
I
I
W
---
E
G
D
D
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
A
D
E
G
V
--
R
A
G
R
S
I
---
P
L
-
K
K
N
V
D
D
A
------
L
K
NPNVTS
V
E
--------
H
V
I
V
L
K
--
R
--
T
G
S
D
I
D
W
Q
E
GRDL
W
W
R
D
L
I
E
K
A
S
P
----
E
H
Q
P
E
-----
A
M
N
A
E
D
P
L
F
I
L
-
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
Y
L
V
Y
A
A
T
T
F
K
Y
---
V
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
-
F
-
E
-
G
VPN
W
P
T
P
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
I
E
G
T
D
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
G
KEK
C
P
V
V
D
T
W
W
Q
T
E
T
GGFMI
T
P
L
P
G
A
I
E
---
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
A
T
E
G
N
L
V
I
------
T
D
---
S
---
W
P
G
Q
A
R
T
L
F
G
D
H
E
R
F
E
Q
T
Y
F
S
T
F
KNM
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
--
P
S
P
--
E
L
Y
A
E
V
R
N
W
V
A
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
---------------