@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2406: (2016-04-03 )
MELLKHLSQRQYIDGEWVESTNKNTRDIINPYNQEVIFTVSEGTKEDAERAILAARRAFESGEWSQETAEKRGKKVRAIADKIKEHREALARLETLDTGKTLEESYADMDDIHNVFMYFAGLADKDGGEMIDSPIPDTESKIVKEPVGVVTQITPWNYPLLQASWKIAPALATGCSLVMKPSEITPLTTIRVFELMEEVGFPKGTINLILGAGSEVGDVMSGHKEVDLVSFTGGIETGKHIMKNAANNVTNIALELGGKNPNIIFDDADFELAVDQALNGGYFHAGQVCSAGSRILVQNSIKDKFEQALIDRVKKIKLGNGFDADTEMGPVISTEHRNKIESYMDVAKAEGATIAVGGKRPDRDDLKDGLFFEPTVITNCDTSMRIVQEEVFGPVVTVEGFETEQEAIQLANDSIYGLAGAVFSKDIGKAQRVANKLKLGTVWINDFHPYFAQAPWGGYKQSGIGRELGKEGLEEYLVSKHILTNTNPQLVNWFSK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
L
L
K
H
L
S
QRQYIDGEWVESTNKN
T
R
D
IINPYN
Q
E
V
I
F
T
VSEG
T
K
E
D
A
E
R
A
I
L
A
A
R
R
AFESGEW
S
Q
E
T
A
E
KRG
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
TLDTG
K
T
L
E
E
S
YA
D
M
D
D
I
H
N
V
F
M
Y
F
AGLADKDGGEMIDSPIPDT
E
S
K
I
V
KEPV
G
V
V
T
QITPWNYPLLQAS
W
K
IA
P
A
L
ATG
C
S
L
V
MKPSEITP
L
T
T
I
R
V
F
E
L
M
E
E
VGFPKG
T
I
N
L
I
L
GAGS
E
V
G
D
V
MSGHK
E
V
D
L
V
S
FTGGI
E
T
G
K
H
I
M
K
N
AANNV
T
N
I
A
L
E
LGGKNP
N
I
I
F
DDAD
F
E
L
A
V
D
QALNGGYFHAG
Q
V
CSAG
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
IKLGNGFDADTEMG
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
KAEG
A
T
I
A
VGGKRP
D
R
D
D
LKDG
L
F
FEP
T
V
ITNCD
T
S
M
R
I
V
Q
E
EVFG
P
V
V
T
VEGFE
T
E
Q
E
A
I
Q
LANDS
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
KL
K
L
G
T
V
W
INDF
H
P
Y
FAQAPWGGYKQSG
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
ILTNTNPQLVNWFSK
30
PsiBlast_CBE
99.35
99%
-71
- C3 -
4QN2
1
?
D:
[22-517]
M
E
L
L
K
H
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
S
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
K
8
PsiBlast_PDB
99.27
99%
-72
- C3 -
4Q92
4
?
A:
[22-517]
M
E
L
L
K
H
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
S
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
K
28
PsiBlast_CBE
99.24
99%
-71
- C3 -
4QN2
1
?
F:
[22-517]
M
E
L
L
K
H
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
S
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
K
45
PsiBlast_CBE
99.21
99%
-73
- C3 -
4ZXU
3
?
C:
[22-517]
M
E
L
L
K
H
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
F
M
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
K
29
PsiBlast_CBE
99.19
99%
-72
- C3 -
4QN2
1
?
E:
[22-517]
M
E
L
L
K
H
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
S
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
K
26
PsiBlast_CBE
99.18
99%
-72
- C3 -
4QN2
2
?
H:
[22-517]
M
E
L
L
K
H
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
S
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
K
10
PsiBlast_PDB
99.15
99%
-73
- C3 -
4ZXU
4
?
A:
[22-517]
M
E
L
L
K
H
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
F
M
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
K
44
PsiBlast_CBE
99.14
99%
-74
- C3 -
4ZXU
5
?
D:
[22-517]
M
E
L
L
K
H
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
F
M
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
K
46
PsiBlast_CBE
99.07
99%
-73
- C3 -
4ZXU
3
?
B:
[22-517]
M
E
L
L
K
H
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
F
M
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
K
32
PsiBlast_CBE
99.07
99%
-72
- C3 -
4QN2
2
?
B:
[22-517]
M
E
L
L
K
H
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
S
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
K
24
PsiBlast_CBE
99.06
99%
-72
- C3 -
4NEA
6
?
B:
[25-520]
M
E
L
L
K
H
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
K
4
PsiBlast_PDB
99.04
99%
-72
- C3 -
4QN2
2
?
A:
[22-517]
M
E
L
L
K
H
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
S
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
K
31
PsiBlast_CBE
98.95
99%
-72
- C3 -
4QN2
1
?
C:
[22-517]
M
E
L
L
K
H
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
S
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
K
42
PsiBlast_CBE
98.68
99%
-73
- C3 -
4ZXU
2
?
F:
[23-517]
-
E
L
L
K
H
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
F
M
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
K
27
PsiBlast_CBE
98.67
99%
-72
- C3 -
4QN2
1
?
G:
[22-517]
M
E
L
L
K
H
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
S
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
K
40
PsiBlast_CBE
98.63
99%
-73
- C3 -
4ZXU
5
?
H:
[22-517]
M
E
L
L
K
H
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
F
M
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
K
39
PsiBlast_CBE
98.62
99%
-75
- C3 -
4ZWL
3
?
B:
[22-517]
M
E
L
L
K
H
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
F
P
L
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
K
34
PsiBlast_CBE
98.60
99%
-72
- C3 -
4ZWL
4
?
G:
[22-517]
M
E
L
L
K
H
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
F
P
L
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
K
25
PsiBlast_CBE
98.52
99%
-70
- C3 -
4MPB
1
?
B:
[25-520]
M
E
L
L
K
H
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
K
43
PsiBlast_CBE
98.48
99%
-74
- C3 -
4ZXU
3
?
E:
[22-517]
M
E
L
L
K
H
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
F
M
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
K