@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2413: (2016-04-03 )
MKLNTSNSPFTEKQVTEINNLLQTLTESQQQWLSGFLLANSNDTTSDSNQQQLETEVWQQSQISEEQATSTTYMLQNKEPHIEANQRHVTVLYGSESGNAMRLAEIFSERLSDIGHQVVLMSMDEYDTTNIAQLEDLFIITSTHGEGEPPDNAWDFFEFLEDDNAPNLNHVRYSVLALGDQTYEFFCQAGKDVDALLENLGAERICKRVDCDIDYEEDAEKWMADIINMIDTTSEGIQSESVISESIKSAKEKKYSKLNPYQAEVLANINLNGTDSNKETRHIEFLLDDFSESYEPGDCIVALPQNDPELVEKLISMLGWDPQSPVPINDRGDTVPIVEALTSHFEFTKLTLPLLKNADIYFDNEELSERIQDESWAREYVINRDFIDLITDFPTIELQPENMYQILRKLPPREYSISSSFMATPDEVHITVGTVRYQAHGRERKGVCSVHFAERIKPGDIVPIYLKKNPNFKFPMKQDIPVIMIGPGTGIAPFRAYLQEREELGMTGKTWLFFGDQHRSSDFLYEEEIEEWLENGNLTRVDLAFSRDQEHKEYVQHRIMEESERFNEWIEQGAAIYICGDEKCMAKDVHQAIKDVLVKERHISQEEAELLLRQMKQQQRYQRDVY
Atome Classification :
(39 SA)
.........10........20........30........40........50........60........70........80........90........100.......110..-......120.----......130-..--....-----.-----.-.140.......150.......160..---------------...----------------..170.......180.......190.......200...--.--...210--..--.---....220-------.-------...---------...------230.-----....---..240---..------.--------.----.------.-.-------------.---------------250--------------...-------------------..------------------...260.......270-.......280.......-290-.......300.......310......--------------------------.320...--...----------.------------------330----...--------.----------...----.--.----340......-----.-----350.-.-.....360..----..-------...370.----......380...------......390..---.....400....-...410.......420..---.....430......---.---440........450.......460----------........-------------.470......-.480.......490....-----..-----.500---...-----.------..-..----510.......520.......530...-.-...540.....----..550----........560--.-......570-.-...-....580.......590.......600.......610.......620....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKLNTSNSPF
T
E
K
Q
V
T
E
I
N
N
L
L
Q
T
L
T
E
S
Q
Q
Q
W
L
S
G
F
L
L
ANSNDTTSDS
N
Q
Q
Q
L
E
T
E
V
W
Q
Q
SQIS
E
E
QATS
T
T
Y
M
LQNKEPHIEANQ
R
H
V
T
V
L
Y
GSESGN
A
M
R
L
A
E
I
F
S
E
R
L
-
S
D-IG
H
Q
V
V
L
M
SM----DEYDTT
N
---
I
A
--
Q
L
E
D
-----
L
-----
F
-
I
I
TSTHGEGEPPD
N
A
W
D
F
F
E
F
L
EDDN---------------APN----------------LN
H
V
R
Y
S
V
L
ALGD
Q
T
Y
E
F
F
C
QAGK
D
V
D
A
L
L
E
NL
G
A
E
R
I
--
C
--
K
RVDCD--ID--
Y
---
E
E
D
A
E
K
W
-------
M
-------
A
D
I
---------
I
N
M
------IDTT-----SEGI---
Q
S
E
S
----
V
I
------
S
--------
E
----
S
------
I
-
K
-------------
S
---------------
A
K
---------------
E
K
K-------------------YS------------------KLNPY
Q
A
E
V
L
A
N
I
NLN-GTDSNKE
T
R
H
I
E
F
L
L
D
D
-
F
SE-SYEPG
D
C
I
V
ALPQN
D
P
E
L
V
E
K
L
I
S
ML--------------------------GWDPQSP--VPI----------N------------------D------RGD--------T----------
V
P
I
----
V
--
E
----
A
L
T
SHF
E
F
T
-----
K
-----
L
T
L
P
-L-LKNA
D
I
Y
FD
N
----
E
E
-------
L
S
E
R
IQ
D
----
E
S
W
A
R
E
Y
--VIN------
R
D
F
I
D
L
ITDFP---
T
I
E
LQ
P
E
N
M
Y
Q
I
-
L
R
KLPPREYSISSSFMAT---P
D
E
V
H
I
T
V
G
T
V
R
Y
Q---A---H-GRERKG
V
C
S
V
H
F
A
ERIKPG
D
------------
I
V
P
I
Y
L
KK-------------NPNFKFPMKQ-DI
P
V
I
M
IGPGTG
I
A
P
F
R
A
-----
Y
L
-----
Q
E
R
----
E
EL-----G------MT-G
K
----
T
W
L
F
FGDQHRSSDF
L
Y
E
E
E
I
E
E
W
L
EN-G-N
L
T
R
V
D
L
A
FSR----
D
Q
E
-
H
----
K
E
Y
V
Q
H
R
I
M
E
E
--
S
-
E
R
F
N
E
W
I
-E-Q-G
A
A
-
I
Y
I
CGD
E
K
C
M
A
K
D
V
H
Q
A
I
K
D
V
L
V
K
E
RHI
S
Q
E
E
A
E
L
L
L
R
Q
M
K
Q
Q
Q
R
Y
QRDVY-
101
Fugue
85.31
31%
-80
- C2 -
1JA1
4
NCPR_RAT
A:
[7-622]
--------
P
V
K
E
S
------
S
F
V
E
K
M
K
K
T
G
---------------------------------------------------------
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
-
Y
G
M
R
G
M
S
A
D
P
----
E
E
Y
D
L
A
D
---
L
S
--
S
L
P
E
IDK
S
L
V
-----
V
-
F
C
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
----------------
V
D
----------------
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
--
F
E
L
G
L
G
D
D
D
--
G
N
--
L
---
E
E
D
F
I
T
W
-------
R
-------
E
Q
F
---------
W
P
A
------
V
C
E
F
F
GVEA
T
G
E
E
---
S
S
I
R
----
Q
Y
------
E
--------
L
----
V
------
V
-
H
-------------
E
---------------
D
M
---------------
D
V
A
KVYTGEMGRLKSYENQKPP
F
D
------------------
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
--
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
I
-
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
--------------------------
G
A
D
L
D
V
I
--
M
S
L
----------
N
------------------
N
------
L
D
E
--------
E
SNKKHPFPCP
T
T
Y
----
R
--
T
----
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
-----
V
L
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
----
E
H
-------
L
H
K
M
A
S
S
----
S
G
E
G
K
E
L
--
Y
L
S
WVVEAR
R
H
I
L
A
I
L
Q
D
Y
P
---
S
L
R
P
P
I
D
H
L
C
E
L
-
L
P
R
L
Q
A
R
Y
Y
A
I
A
S
S
S
K
V
H
---
P
N
S
V
H
I
C
A
V
A
V
E
Y
E
---
A
---
K
S
G
R
V
N
K
G
V
A
T
S
W
L
R
A
K
E
P
A
G
E
NGGRA-------
L
V
P
M
F
V
R
K
-------------
S
-
Q
F
R
L
P
F
K
S
-
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
----
A
W
L
-----
R
------
E
Q
-
G
K
E
V
G
E
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
-
G
-
A
L
T
Q
L
N
V
A
F
S
R
----
E
Q
A
-
H
----
K
V
Y
V
Q
H
L
L
K
R
D
--
R
-
E
H
L
W
K
L
I
H
E
-
G
-
G
A
H
-
I
Y
V
A
G
D
A
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
N
V
W
S
14
PsiBlast_PDB
85.08
29%
-90
- C2 -
3FJO
2
NCPR_HUMAN (first)
A:
[34-636]
---------------------------------------------------------------------------------
V
T
E
N
N
K
N
Y
L
V
L
Y
A
S
Q
T
G
T
A
E
D
Y
A
K
K
F
S
K
E
L
V
A
K
-
F
N
L
N
V
M
C
A
D
V
----
E
N
Y
D
F
E
S
---
L
N
--
D
V
P
V
-----
I
-----
V
S
I
F
I
S
T
Y
G
E
G
D
F
P
D
G
A
V
N
F
E
D
F
I
C
N
A
E
---------------
A
G
A
----------------
L
S
N
L
R
Y
N
M
F
G
L
G
N
S
T
Y
E
F
F
N
G
A
A
K
K
A
E
K
H
L
S
A
A
G
A
I
R
L
--
G
--
K
L
G
E
A
D
--
D
G
--
A
GT
T
D
E
D
Y
M
A
W
-------
K
-------
D
S
I
---------
L
E
V
L
K
D
E
L
G
V
E
A
T
-----
G
E
E
S
SIR
Q
Y
E
L
----
V
V
------
H
--------
T
----
D
------
I
-
D
-------------
A
---------------
A
K
VYMGEMGRLKSYENQ
K
P
P
-------------------
F
D
------------------
A
K
N
P
F
L
A
A
V
T
T
N
R
K
L
N
Q
G
T
E
--
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
I
-
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
L
G
K
I
L
--------------------------
G
A
D
L
D
V
V
--
M
S
L
----------
N
------------------
N
LDEESN
K
K
H
--------
P
----------
F
P
C
PTS
Y
R
--
T
----
A
L
T
Y
Y
L
D
I
T
-----
N
PPR
T
N
V
L
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
----
E
L
-------
L
R
K
M
A
S
S
----
S
G
E
G
K
E
L
--
Y
L
S
WVVEAR
R
H
I
L
A
I
L
Q
D
C
P
---
S
L
R
P
P
I
D
H
L
C
E
L
-
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
K
V
H
---
P
N
S
V
H
I
C
A
V
V
V
E
Y
E
---
T
---
K
A
G
R
I
N
K
G
V
A
T
N
W
L
R
A
K
E
P
A
--R
A
----------
L
V
P
M
F
V
R
K
-------------
S
-
Q
F
R
L
P
F
K
A
-
T
T
P
V
I
M
V
G
P
G
T
G
V
A
P
F
I
G
-----
F
I
-----
Q
E
R
----
A
W
L
-----
R
------
Q
Q
-
G
K
E
V
G
E
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
Q
F
H
R
D
-
G
-
A
L
T
Q
L
N
V
A
F
S
R
--------
H
----
K
V
Y
V
Q
H
L
L
K
Q
D
--
R
-
E
H
L
W
K
L
I
-
E
-
G
-
G
A
H
-
I
Y
V
C
G
D
A
R
N
M
A
R
D
V
Q
N
T
F
Y
D
I
V
A
E
L
G
A
M
E
H
A
Q
A
V
D
Y
I
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
-
77
HHSearch
83.62
31%
-80
- C2 -
3QE2
4
NCPR_HUMAN
A:
[12-617]
-------------------------------------------------------------------------------
E
K
M
K
K
T
G
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
-
Y
G
M
R
G
M
S
A
D
P
----
E
E
Y
D
L
A
D
LSS
L
P
EI
D
N
A
L
-----
V
-----
V
-
F
C
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
----------------
V
D
----------------
L
S
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
K
R
L
E
Q
L
G
A
Q
R
I
--
F
--
E
L
G
L
G
D
--
D
D
--
G
N
L
-
E
E
D
F
I
T
W
-------
R
-------
E
Q
F
---------
W
L
A
------
V
C
E
H
-----
F
G
V
E
---
A
T
--SSIR
Q
Y
------
E
--------
L
V
V
HT
D
ID----
A
-
A
KVYMGEMGRLKSY
E
---------------
N
Q
---------------
K
P
P
-------------------
F
D
------------------
A
K
N
P
F
L
A
A
V
T
T
N
R
K
L
N
-
Q
G
-
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
I
-
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
L
G
K
I
L
--------------------------
G
A
D
L
D
V
V
--
M
S
L
N
N
LDEESNKK
H
------------------
P
------
F
P
C
--------
P
----------
T
S
Y
----
R
--
T
----
A
L
T
Y
Y
L
D
I
T
-----
N
-----
P
P
R
T
N
V
-
L
Y
E
L
A
Q
Y
A
S
E
P
S
E
Q
E
L
-------
L
R
K
M
A
S
S
SG
E
G
K
E
L
Y
L
S
W
VV
E
A
R
------
R
H
I
L
A
I
L
Q
D
C
P
SL-
R
P
P
I
D
--
H
L
C
E
L
-
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
K
V
H
---
P
N
S
V
H
I
C
A
V
V
V
E
Y
E
T
--
K
---
A
-
G
R
I
N
K
G
V
A
T
N
W
L
R
A
K
E
P
V
--R
A
----------
L
V
P
M
F
V
R
--------------
K
S
Q
F
R
L
P
F
K
A
-
T
T
P
V
I
M
V
G
P
G
T
G
V
A
P
F
I
G
-----
F
I
-----
Q
E
R
----
A
W
L
R
Q
Q
G-
K
------
E
V
-
G
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
Q
F
H
R
D
-
G
-
A
L
T
Q
L
N
V
A
F
S
R
----
E
Q
S
-
H
----
K
V
Y
V
Q
H
L
L
K
Q
D
--
R
-
E
H
L
W
K
L
I
-
E
-
G
-
G
A
H
-
I
Y
V
C
G
D
A
R
N
M
A
R
D
V
Q
N
T
F
Y
D
I
V
A
E
L
G
A
M
E
H
A
Q
A
V
D
Y
I
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
-
15
PsiBlast_PDB
80.99
27%
-80
* C2 *
1TLL
4
NOS1_RAT
A:
[9-654]
-----------------------------------------------------------------------------------
A
K
R
V
K
A
T
I
L
Y
A
T
E
T
G
K
S
Q
A
Y
A
K
T
L
C
E
I
F
-
K
H
--
A
F
D
A
K
A
M
S
M
----
E
E
Y
D
I
V
H
---
L
E
--
H
E
A
L
-----
V
-----
L
-
V
V
T
S
T
F
G
N
G
D
P
P
E
N
G
E
K
F
G
C
A
L
M
E
M
R
---------------
H
--E
E
R
K
S
YKVRFNSVSGP
L
A
N
V
R
F
S
V
F
G
L
G
S
R
A
Y
P
H
F
C
A
F
G
H
A
V
D
T
L
L
E
E
L
G
G
E
R
I
--
L
--
K
M
R
E
G
D
EL
C
G
--
Q
---
E
E
A
F
R
T
W
-------
A
K
K
V
F
K
A
A
C
D
V
---------
F
C
V
------
G
D
D
V
-----
N
I
E
--------------------
S
--------
N
----
D
--------
R
-------------
S
---------------
W
K
---------------
R
N
K
-------------------
F
R
L
T
Y
V
AEAPD
L
T
Q
G
L
S
N
V
H
K
K
R
V
S
A
A
R
L
L
S
R
Q
N
L
Q
-
S
P
K
S
S
R
S
T
I
F
V
R
L
H
T
N
G
-
N
Q
E
L
Q
Y
Q
P
G
D
H
L
G
V
F
P
G
N
H
E
D
L
V
N
A
L
I
E
R
L
EDAPPANHV
V
K
V
E
M
L
E
E
R
N
T
AL
G
V
I
S
N
W
K
D
E
S
R
--
L
P
------------------------------------------------
P
----------
C
T
I
----
F
--
Q
----
A
F
K
Y
Y
L
D
I
T
-----
T
-----
P
P
T
P
-
L
Q
L
Q
Q
F
A
S
L
A
T
N
----
E
K
E
K
Q
R
L
L
V
L
S
K
G
L
Q
E
Y
---
E
E
W
--
K
W
--
G
K
N
------
P
T
M
V
E
V
L
E
E
F
P
---
S
I
Q
M
P
A
T
L
L
L
T
Q
-
L
S
L
L
Q
P
R
Y
Y
S
I
S
S
S
P
D
M
Y
---
P
D
E
V
H
L
T
V
A
I
V
S
Y
H
T
RD
G
---
E
-
G
P
V
H
H
G
V
C
S
-
S
W
L
N
R
I
Q
A
D
D
------------
V
V
P
C
F
V
R
G
-------------
A
P
S
F
H
L
P
R
N
P
-
Q
V
P
C
I
L
V
G
P
G
T
G
I
A
P
F
R
S
-----
F
W
-----
Q
Q
R
Q
F
D
I
Q
H
K
-----
G
------
M
N
P
C
P
----
M
V
L
V
F
G
C
R
Q
S
K
I
D
H
I
Y
R
E
E
T
L
Q
A
K
N
K
-
G
-
V
F
R
E
L
Y
T
A
Y
S
R
----
E
P
D
-
R
P---
K
K
Y
V
Q
D
V
L
Q
E
Q
L
A
E
-
S
V
Y
R
A
L
K
-
E
-
Q
-
G
G
H
-
I
Y
V
C
G
D
-
V
T
M
A
A
D
V
L
K
A
I
Q
R
I
M
T
Q
Q
G
K
L
S
E
E
D
A
G
V
F
I
S
R
L
R
D
D
N
R
Y
H
E
D
I
F
-
78
HHSearch
80.95
30%
-77
- C2 -
1TLL
4
NOS1_RAT
A:
[9-654]
-----------------------------------------------------------------------------------
A
K
R
V
K
A
T
I
L
Y
A
T
E
T
G
K
S
Q
A
Y
A
K
T
L
C
E
I
F
-
K
--
H
A
F
D
A
K
A
M
S
M
----
E
E
Y
D
I
V
H
---
L
E
--
H
E
A
L
-----
V
-----
L
-
V
V
T
S
T
F
G
N
G
D
P
P
E
N
G
E
K
F
G
C
A
L
M
E
M
R
HE
E
R
K
S
YKVRFNSVS-
G
P
----------------
L
A
N
V
R
F
S
V
F
G
L
G
S
R
A
Y
P
H
F
C
A
F
G
H
A
V
D
T
L
L
E
E
L
G
G
E
R
I
--
L
--
K
M
R
E
G
D
--
E
L
CG
Q
---
E
E
A
F
R
T
W
-------
A
-------
K
K
V
---------
F
K
A
------
A
C
D
V
-----
F
C
V
G
---
D
D
V
N
IE-----------SNDRSWKR
N
----
K
F
R
L
T
Y
V
A
E
A
-------------
P
D
L
T
------------
Q
G
---------------
L
S
N
-------------------
V
H
------------------
K
K
R
V
S
A
A
R
L
L
S
R
Q
N
L
Q
-
S
P
K
S
S
R
S
T
I
F
V
R
L
H
T
N
G
N
Q
E
L
-
Q
Y
Q
P
G
D
H
L
G
V
F
P
G
N
H
E
D
L
V
N
A
L
I
E
R
L
--------------------------
E
D
A
P
P
A
N
HV
V
K
V
----------
E
M
L
E
E
R
N
T
AL
G
V
I
S
N
W
K
D
E
S
------
R
L
P
--------
P
----------
C
T
I
----
F
--
Q
----
A
F
K
Y
Y
L
D
I
T
-----
T
-----
P
P
T
P
L
Q
-
L
Q
Q
F
A
S
L
A
T
N
E
K
E
K
Q
R
-------
L
L
V
L
S
K
G
----
L
Q
E
Y
E
E
W
K
W
G
K
N
------
P
T
M
V
E
V
L
E
E
F
P
SI-
Q
M
P
A
T
--
L
L
L
T
Q
-
L
S
L
L
Q
P
R
Y
Y
S
I
S
S
S
P
D
M
Y
---
P
D
E
V
H
L
T
V
A
I
V
S
Y
H
T
--
R
DG-
E
-
G
P
V
H
H
G
V
C
S
S
W
L
N
R
I
Q
-
A
D
D
------------
V
V
P
C
F
V
R
G
-------------
A
P
S
F
H
L
P
R
N
P
-
Q
V
P
C
I
L
V
G
P
G
T
G
I
A
P
F
R
S
-----
F
W
-----
Q
Q
R
----
Q
F
D
I
Q
HKG
M
------
N
P
-
C
P
----
M
V
L
V
F
G
C
R
Q
S
K
I
D
H
I
Y
R
E
E
T
L
Q
A
K
N
K
-
G
-
V
F
R
E
L
Y
T
A
Y
S
R
----
E
P
D
R
P
----
K
K
Y
V
Q
D
V
L
Q
E
Q
--
L
A
E
S
V
Y
R
A
L
-
K
E
Q
-
G
G
H
-
I
Y
V
C
G
D
V
-
T
M
A
A
D
V
L
K
A
I
Q
R
I
M
T
Q
Q
G
K
L
S
E
E
D
A
G
V
F
I
S
R
L
R
D
D
N
R
Y
H
E
D
I
F
-
4
PsiBlast_PDB
77.93
31%
-83
- C2 -
3WKT
3
NCPR_RAT
A:
[17-617]
---------------------------------------------------------------------------------
M
K
K
T
G
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
----
E
E
F
A
N
R
L
-
S
K
-
D
A
H
R
Y
G
M
R
G
M
S
A
DP
E
E
Y
D
L
A
D
---
L
S
--
S
L
P
E
-----
I
DK
S
L
V
V
-
F
C
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
----------------
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
L
--
G
L
G
D
D
D
--
G
N
--
L
---
E
E
D
F
I
T
W
-------
R
E
Q
F
W
---
P
A
V
---------
C
E
F
------
F
G
V
E
-----
A
S
S
I
R--
Q
Y
E
L
----
V
V
------
H
--------
E
----
D
------
M
-
D
-------------
V
---------------
A
K
VYTGEMGRLKSYENQ
K
P
P
-------------------
F
D
------------------
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
Q
G
T
E
--
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
I
-
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
--------------------------
G
A
D
L
D
V
I
--
M
S
L
----------
N
------------------
N
LDEESN
K
K
H
--------
P
----------
F
P
C
----
P
--
T
T
Y
R
T
A
L
T
Y
Y
L
D
I
T
-----
N
PPR
T
N
V
L
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
----
E
H
-------
L
H
K
M
A
S
S
----
S
G
E
G
K
E
L
--
Y
L
S
WVVEAR
R
H
I
L
A
I
L
Q
D
Y
P
---
S
L
R
P
P
I
D
H
L
C
E
L
-
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
K
V
H
---
P
N
S
V
H
I
C
A
V
A
V
E
Y
E
---
A
---
K
S
G
R
V
N
K
G
V
A
T
S
W
L
R
A
K
E
P
A
--------------
L
V
P
M
F
V
R
K
-------------
S
-
Q
F
R
L
P
F
K
S
-
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
----
A
W
L
-----
R
------
E
Q
-
G
K
EV
G
E
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
-
G
-
A
L
T
Q
L
N
V
A
F
S
R
----
E
Q
A
-
H
----
K
V
Y
V
Q
H
L
L
K
R
D
--
R
-
E
H
L
W
K
L
I
-
H
-
E
-
G
G
A
H
I
Y
V
C
G
D
A
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
-
9
PsiBlast_PDB
77.64
31%
-78
- C2 -
1J9Z
3
NCPR_RAT
A:
[17-620]
---------------------------------------------------------------------------------
M
K
K
T
G
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
----
E
E
F
A
N
R
L
-
S
K
-
D
A
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
A
D
---
L
S
--
S
L
P
E
-----
I
DK
S
L
V
V
-
F
C
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
----------------
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
L
--
G
L
G
D
D
D
--
G
N
--
L
---
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
-------
C
E
F
---------
F
G
V
------
E
A
T
G
-----
E
E
S
S
IR-
Q
Y
E
L
----
V
V
------
H
--------
E
----
D
------
M
-
D
-------------
V
---------------
A
K
VYTGEMGRLKSYENQ
K
P
P
-------------------
F
D
------------------
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
Q
G
T
E
--
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
I
-
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
--------------------------
G
A
D
L
D
V
I
--
M
S
L
----------
N
------------------
N
------
L
D
E
ESNKKHPF
P
----------
C
P
T
----
T
Y
R
T
----
A
L
T
Y
Y
L
D
I
T
-----
N
PPR
T
N
V
L
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
----
E
H
-------
L
H
K
M
A
S
S
----
S
G
E
G
K
E
L
--
Y
L
S
WVVEAR
R
H
I
L
A
I
L
Q
D
Y
P
---
S
L
R
P
P
I
D
H
L
C
E
L
-
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
K
V
H
---
P
N
S
V
H
I
C
A
V
A
V
E
Y
E
---
A
---
K
S
G
R
V
N
K
G
V
A
T
S
W
L
R
A
K
E
P
A
G
-G
R
A
---------
L
V
P
M
F
V
R
K
-------------
S
-
Q
F
R
L
P
F
K
S
-
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
----
A
W
L
-----
R
------
E
Q
-
G
K
EV
G
E
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
-
G
-
A
L
T
Q
L
N
V
A
F
S
R
----
E
Q
A
-
H
----
K
V
Y
V
Q
H
L
L
K
R
D
--
R
-
E
H
L
W
K
L
I
-
H
-
E
-
G
G
A
H
I
Y
V
C
G
D
A
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
D
V
--
3
PsiBlast_PDB
77.44
31%
-80
- C2 -
3ES9
3
NCPR_RAT
A:
[17-617]
---------------------------------------------------------------------------------
M
K
K
T
G
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
----
E
E
F
A
N
R
L
-
S
K
-
D
A
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
A
D
---
L
S
--
S
L
P
E
-----
I
DK
S
L
V
V
-
F
C
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
----------------
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
L
--
G
L
G
D
D
D
--
G
N
--
L
---
E
E
D
F
I
T
W
-------
R
E
Q
F
W
---
P
A
V
---------
C
E
F
------
F
G
V
E
-----
A
S
S
I
R--
Q
Y
E
L
----
V
V
------
H
--------
E
----
D
------
M
-
D
-------------
V
---------------
A
K
VYTGEMGRLKSYE
N
Q
K
P
P
-------------------
F
D
------------------
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
Q
G
T
E
--
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
I
-
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
--------------------------
G
A
D
L
D
V
I
--
M
S
L
----------
N
------------------
N
LDEESN
K
K
H
--------
P
----------
F
P
C
----
P
--
T
T
Y
R
T
A
L
T
Y
Y
L
D
I
T
-----
N
PPR
T
N
V
L
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
----
E
H
-------
L
H
K
M
A
S
S
----
S
G
E
G
K
E
L
--
Y
L
S
WVVEAR
R
H
I
L
A
I
L
Q
D
Y
P
---
S
L
R
P
P
I
D
H
L
C
E
L
-
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
K
V
H
---
P
N
S
V
H
I
C
A
V
A
V
E
Y
E
---
A
---
K
S
G
R
V
N
K
G
V
A
T
S
W
L
R
A
K
E
P
---R
A
----------
L
V
P
M
F
V
R
K
-------------
S
-
Q
F
R
L
P
F
K
S
-
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
----
A
W
L
-----
R
------
E
Q
-
G
K
E
V
G
E
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
-
G
-
A
L
T
Q
L
N
V
A
F
S
R
----
E
Q
A
-
H
----
K
V
Y
V
Q
H
L
L
K
R
D
--
R
-
E
H
L
W
K
L
I
-
H
-
E
-
G
G
A
H
I
Y
V
C
G
D
A
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
-
13
PsiBlast_PDB
77.43
30%
-78
- C2 -
1JA1
4
NCPR_RAT
A:
[17-621]
---------------------------------------------------------------------------------
M
K
K
T
G
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
----
E
E
F
A
N
R
L
-
S
K
-
D
A
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
A
D
---
L
S
--
S
L
P
E
-----
I
DK
S
L
V
V
-
F
C
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
----------------
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
L
--
G
L
G
D
D
D
--
G
N
--
L
---
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
-------
C
E
F
---------
F
G
V
------
E
A
T
G
-----
E
E
S
S
IR-
Q
Y
E
L
----
V
V
------
H
--------
E
----
D
------
M
-
D
-------------
V
---------------
A
K
VYTGEMGRLKSYENQ
K
P
P
-------------------
F
D
------------------
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
Q
G
T
E
--
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
I
-
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
--------------------------
G
A
D
L
D
V
I
--
M
S
L
----------
N
------------------
N
LDEESN
K
K
H
--------
P
----------
F
P
C
----
P
--
T
T
Y
R
T
A
L
T
Y
Y
L
D
I
T
-----
N
PPR
T
N
V
L
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
----
E
H
-------
L
H
K
M
A
S
S
----
S
G
E
G
K
E
L
--
Y
L
S
WVVEAR
R
H
I
L
A
I
L
Q
D
Y
P
---
S
L
R
P
P
I
D
H
L
C
E
L
-
L
P
R
L
Q
A
R
Y
Y
A
I
A
S
S
S
K
V
H
---
P
N
S
V
H
I
C
A
V
A
V
E
Y
E
---
A
---
K
S
G
R
V
N
K
G
V
A
T
S
W
L
R
A
K
E
P
A
G
E
NGGRA-------
L
V
P
M
F
V
R
K
-------------
S
-
Q
F
R
L
P
F
K
S
-
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
----
A
W
L
-----
R
------
E
Q
-
G
K
E
V
G
E
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
-
G
-
A
L
T
Q
L
N
V
A
F
S
R
----
E
Q
A
-
H
----
K
V
Y
V
Q
H
L
L
K
R
D
--
R
-
E
H
L
W
K
L
I
-
H
-
E
-
G
G
A
H
I
Y
V
A
G
D
A
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
N
V
W
-
12
PsiBlast_PDB
77.18
30%
-77
- C2 -
3QFC
4
NCPR_HUMAN
A:
[14-617]
---------------------------------------------------------------------------------
M
K
K
T
G
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
----
E
E
F
A
N
R
L
-
S
K
-
D
A
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
A
D
---
L
S
--
S
L
P
E
-----
I
DN
A
L
V
V
-
F
C
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
----------------
L
S
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
K
R
L
E
Q
L
G
A
Q
R
I
F
E
L
--
G
L
G
D
D
D
--
G
N
--
L
---
E
E
D
F
I
T
W
-------
R
-------
E
Q
F
W
L
A
V
C
E
H
FG
V
E
A
------
T
G
E
E
-----
S
S
I
R
---
Q
Y
E
L
----
V
V
------
H
--------
T
----
D
------
I
-
D
-------------
A
---------------
A
K
VYMGEMGRLKSYENQ
K
P
P
-------------------
F
D
------------------
A
K
N
P
F
L
A
A
V
T
T
N
R
K
L
N
Q
G
T
E
--
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
I
-
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
L
G
K
I
L
--------------------------
G
A
D
L
D
V
V
--
M
S
L
----------
N
------------------
N
LDEESN
K
K
H
--------
P
----------
F
P
C
PTS
Y
R
--
T
----
A
L
T
Y
Y
L
D
I
T
-----
N
PPR
T
N
V
L
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
----
E
L
-------
L
R
K
M
A
S
S
----
S
G
E
G
K
E
L
--
Y
L
S
WVVEAR
R
H
I
L
A
I
L
Q
D
C
P
---
S
L
R
P
P
I
D
H
L
C
E
L
-
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
K
V
H
---
P
N
S
V
H
I
C
A
V
V
V
E
Y
E
---
T
---
K
A
G
R
I
N
K
G
E
A
T
N
W
L
R
A
K
E
P
V
--R
A
----------
L
V
P
M
F
V
R
K
-------------
S
-
Q
F
R
L
P
F
K
A
-
T
T
P
V
I
M
V
G
P
G
T
G
V
A
P
F
I
G
-----
F
I
-----
Q
E
R
----
A
W
L
-----
R
------
Q
Q
-
G
K
E
V
G
E
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
Q
F
H
R
D
-
G
-
A
L
T
Q
L
N
V
A
F
S
R
----
E
Q
S
-
H
----
K
V
Y
V
Q
H
L
L
K
Q
D
--
R
-
E
H
L
W
K
L
I
-
E
-
G
-
G
A
H
-
I
Y
V
C
G
D
A
R
N
M
A
R
D
V
Q
N
T
F
Y
D
I
V
A
E
L
G
A
M
E
H
A
Q
A
V
D
Y
I
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
-
10
PsiBlast_PDB
76.94
30%
-77
- C2 -
3QE2
4
NCPR_HUMAN
A:
[14-617]
---------------------------------------------------------------------------------
M
K
K
T
G
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
----
E
E
F
A
N
R
L
-
S
K
-
D
A
H
R
Y
G
M
R
G
M
S
A
DP
E
E
Y
D
L
A
D
---
L
S
--
S
L
P
E
-----
I
DN
A
L
V
V
-
F
C
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
----------------
L
S
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
K
R
L
E
Q
L
G
A
Q
R
I
F
E
L
--
G
L
G
D
D
D
--
G
N
--
L
---
E
E
D
F
I
T
W
-------
R
-------
E
Q
F
W
L
A
V
C
E
H
F
G
V
E
A
------
T
--------
S
S
I
R
---
Q
Y
E
L
----
V
V
------
H
--------
T
----
D
------
I
-
D
-------------
A
---------------
A
K
VYMGEMGRLKSYENQ
K
P
P
-------------------
F
D
------------------
A
K
N
P
F
L
A
A
V
T
T
N
R
K
L
N
Q
G
T
E
--
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
I
-
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
L
G
K
I
L
--------------------------
G
A
D
L
D
V
V
--
M
S
L
----------
N
------------------
N
LDEESN
K
K
H
--------
P
----------
F
P
C
PTS
Y
R
--
T
----
A
L
T
Y
Y
L
D
I
T
-----
N
PPR
T
N
V
L
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
----
E
L
-------
L
R
K
M
A
S
S
----
S
G
E
G
K
E
L
--
Y
L
S
WVVEAR
R
H
I
L
A
I
L
Q
D
C
P
---
S
L
R
P
P
I
D
H
L
C
E
L
-
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
K
V
H
---
P
N
S
V
H
I
C
A
V
V
V
E
Y
E
---
T
---
K
A
G
R
I
N
K
G
V
A
T
N
W
L
R
A
K
E
P
V
--R
A
----------
L
V
P
M
F
V
R
K
-------------
S
-
Q
F
R
L
P
F
K
A
-
T
T
P
V
I
M
V
G
P
G
T
G
V
A
P
F
I
G
-----
F
I
-----
Q
E
R
----
A
W
L
-----
R
------
Q
Q
-
G
K
E
V
G
E
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
Q
F
H
R
D
-
G
-
A
L
T
Q
L
N
V
A
F
S
R
----
E
Q
S
-
H
----
K
V
Y
V
Q
H
L
L
K
Q
D
--
R
-
E
H
L
W
K
L
I
-
E
-
G
-
G
A
H
-
I
Y
V
C
G
D
A
R
N
M
A
R
D
V
Q
N
T
F
Y
D
I
V
A
E
L
G
A
M
E
H
A
Q
A
V
D
Y
I
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
-
83
HHSearch
76.88
42%
-86
- C2 -
1DDG
1
CYSJ_ECOLI
A:
[5-374]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-------------------
Y
S
------------------
K
D
A
P
L
V
A
S
L
S
V
N
Q
K
I
T
-
G
R
N
S
E
K
D
V
R
H
I
E
I
D
L
G
D
-
S
G
L
-
R
Y
Q
P
G
D
A
L
G
V
W
Y
Q
N
D
P
A
L
V
K
E
L
V
E
L
L
--------------------------
W
L
K
G
D
E
P
--
V
T
V
------------------------------------
E
G
K
--------
T
----------
L
P
L
----
N
--
E
----
A
L
Q
W
H
F
E
L
T
-----
V
-----
N
T
A
N
-
I
-
V
E
N
Y
A
T
L
T
R
S
----
E
T
-------
L
L
P
L
V
G
D
----
K
A
K
L
Q
H
Y
--
A
A
T
------
T
P
I
V
D
M
V
R
F
S
P
----
A
Q
L
D
A
E
A
L
I
N
L
-
L
R
P
L
T
P
R
L
Y
S
I
A
S
S
Q
A
E
V
---
E
N
E
V
H
V
T
V
G
V
V
R
Y
D
---
V
---
E
-
G
R
A
R
A
G
G
A
S
S
F
L
A
D
R
V
E
E
E
G
------------
E
V
R
V
F
I
E
H
-------------
N
D
N
F
R
L
P
A
N
P
-
E
T
P
V
I
M
I
G
P
G
T
G
I
A
P
F
R
A
-----
F
M
-----
Q
Q
R
----
A
A
D
-----
E
------
A
P
-
G
K
----
N
W
L
F
F
G
N
P
H
F
T
E
D
F
L
Y
Q
V
E
W
Q
R
Y
V
K
E
-
G
-
V
L
T
R
I
D
L
A
W
S
R
----
D
Q
K
-
E
----
K
V
Y
V
Q
D
K
L
R
E
Q
--
G
-
A
E
L
W
R
W
I
-
N
-
D
-
G
A
H
-
I
Y
V
C
G
D
A
N
R
M
A
K
D
V
E
Q
A
L
L
E
V
I
A
E
F
G
G
M
D
T
E
A
A
D
E
F
L
S
E
L
R
V
E
R
R
Y
Q
R
D
V
Y
-
6
PsiBlast_PDB
76.55
31%
-76
- C2 -
3OJW
2
NCPR_RAT
A:
[17-621]
---------------------------------------------------------------------------------
M
K
K
T
G
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
----
E
E
F
A
N
R
L
-
S
K
-
D
A
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
A
D
---
L
S
--
S
L
P
E
-----
I
DK
S
L
V
V
-
F
A
M
A
T
Y
G
E
G
D
P
T
C
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
----------------
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
L
--
G
L
G
D
D
D
--
G
N
--
L
---
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
-------
A
E
F
---------
F
G
V
------
E
A
T
G
-----
E
E
S
S
IR-
Q
Y
E
L
----
V
V
------
H
--------
E
----
D
------
M
-
D
-------------
V
---------------
A
K
VYTGEMGRLKSYENQ
K
P
P
-------------------
F
D
------------------
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
Q
G
T
E
--
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
I
-
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
--------------------------
G
A
D
L
D
V
I
--
M
S
L
----------
N
------------------
N
------
L
D
E
ESNKKHPF
P
----------
T
P
T
----
T
Y
R
T
----
A
L
T
Y
Y
L
D
I
T
-----
N
PPR
T
N
V
L
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
----
E
H
-------
L
H
K
M
A
S
S
----
S
G
E
G
K
E
L
--
Y
L
S
WVVEAR
R
H
I
L
A
I
L
Q
D
Y
P
---
S
L
R
P
P
I
D
H
L
L
E
L
-
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
K
V
H
---
P
N
S
V
H
I
T
A
V
A
V
E
Y
E
---
A
---
K
S
G
R
V
N
K
G
V
A
T
S
W
L
R
A
K
E
P
A
G
-
R
A
----------
L
V
P
M
F
V
C
K
-------------
S
-
Q
F
R
L
P
F
K
S
-
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
----
A
W
L
-----
R
------
E
Q
-
G
K
E
V
G
E
T
L
L
Y
Y
G
A
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
-
G
-
A
L
T
Q
L
N
V
A
F
S
R
----
E
Q
A
-
H
----
K
V
Y
V
Q
H
L
L
K
R
D
--
R
-
E
H
L
W
K
L
I
-
H
-
E
-
G
G
A
H
I
Y
V
C
G
D
A
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
-
79
HHSearch
76.46
29%
-70
- C2 -
2BPO
5
NCPR_YEAST
A:
[44-682]
--------------------------------------------------------------------------------
V
V
T
E
N
N
K
N
Y
L
V
L
Y
A
S
Q
T
G
T
A
E
G
F
A
K
A
F
S
K
E
L
-
V
A
K
F
N
L
N
V
M
C
A
D
V
----
E
N
Y
D
F
E
S
---
L
N
--
D
V
P
V
I
----
V
-----
S
-
I
F
I
S
T
Y
G
E
G
D
F
P
D
G
A
V
N
F
E
D
F
I
C
N
A
E
---------------
A
G
A
----------------
L
S
N
L
R
Y
N
M
F
G
L
G
N
S
T
Y
E
F
F
N
G
A
A
K
K
A
E
K
H
L
S
A
A
G
A
I
R
L
--
G
--
K
L
G
E
A
D
--
D
G
--
A
GT
T
D
E
D
Y
M
A
W
-------
K
-------
D
S
I
---------
L
E
V
------
L
K
D
E
-----
L
H
L
D
---
E
Q
E
A
----
K
F
T
S
QFQ
Y
T
V
L
------
N
E
IT-
D
SMSLG-
E
-
P
-------------
S
AHYLPSHQLNRNADG
I
Q
---------------
L
G
P
-------------------
F
D
------------------
L
S
Q
P
Y
I
A
P
I
V
K
S
R
E
L
F
-
S
S
-
N
D
R
N
C
I
H
S
E
F
D
L
S
G
-
S
N
I
-
K
Y
S
T
G
D
H
L
A
V
W
P
S
N
P
L
E
K
V
E
Q
F
L
S
I
F
--------------------------
N
L
D
P
E
T
I
--
F
D
L
K
P
LDPTVK--
V
------------------
P
------
F
P
T
--------
P
----------
T
T
I
----
G
--
A
----
A
I
K
H
Y
L
E
I
T
-----
G
-----
P
V
S
R
Q
L
-
F
S
S
L
I
Q
F
A
P
N
A
D
V
K
E
K
-------
L
T
L
L
S
K
D
----
K
D
Q
F
A
V
E
IT
S
K
Y
------
F
N
I
A
D
A
L
K
Y
L
S
DGA
K
W
D
T
V
P
M
Q
F
L
V
E
S
V
P
Q
M
T
P
R
Y
Y
S
I
S
S
S
S
L
S
E
---
K
Q
T
V
H
V
T
S
I
V
E
N
F
P
N--
P
ELP
D
-
A
P
P
V
V
G
V
T
T
N
L
L
R
N
I
Q
-
L
A
Q
N
NVNIAETNLPV
H
Y
D
L
N
G
P
R
KLFANY
K
L
P
V
H
V
R
R
S
N
F
R
L
P
S
N
P
-
S
T
P
V
I
M
I
G
P
G
T
G
V
A
P
F
R
G
-----
F
I
-----
R
E
R
----
V
A
F
-----
L
E
S
Q
KN
V
S
L
-
G
K
----
H
I
L
F
Y
G
S
R
N
T
D
-
D
F
L
Y
Q
D
E
W
P
E
Y
A
K
K
-
L
D
G
S
F
E
M
V
V
A
H
S
R
----
L
P
N
T
K
----
K
V
Y
V
Q
D
K
L
K
D
Y
--
E
-
D
Q
V
F
E
M
I
-
N
-
N
-
G
A
F
-
I
Y
V
C
G
D
A
K
G
M
A
K
G
V
S
T
A
L
V
G
I
L
S
R
G
K
S
I
T
T
D
E
A
T
E
L
I
K
M
L
K
T
S
G
R
Y
Q
E
D
V
W
-
7
PsiBlast_PDB
76.40
31%
-74
- C2 -
3OJX
3
NCPR_RAT
A:
[17-621]
---------------------------------------------------------------------------------
M
K
K
T
G
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
----
E
E
F
A
N
R
L
-
S
K
-
D
A
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
A
D
---
L
S
--
S
L
P
E
-----
I
DK
S
L
V
V
-
F
A
M
A
T
Y
G
E
G
D
P
T
C
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
----------------
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
L
--
G
L
G
D
D
D
--
G
N
--
L
---
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
-------
A
E
F
---------
F
G
V
------
E
A
T
G
-----
E
E
S
S
IR-
Q
Y
E
L
----
V
V
------
H
--------
E
----
D
------
M
-
D
-------------
V
---------------
A
K
VYTGEMGRLKSYENQ
K
P
P
-------------------
F
D
------------------
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
Q
G
T
E
--
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
I
-
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
--------------------------
G
A
D
L
D
V
I
--
M
S
L
----------
N
------------------
N
------
L
D
E
ESNKKHPF
P
----------
T
P
T
----
T
Y
R
T
----
A
L
T
Y
Y
L
D
I
T
-----
N
PPR
T
N
V
L
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
----
E
H
-------
L
H
K
M
A
S
S
----
S
G
E
G
K
E
L
--
Y
L
S
WVVEAR
R
H
I
L
A
I
L
Q
D
Y
P
---
S
L
R
P
P
I
D
H
L
L
E
L
-
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
K
V
H
---
P
N
S
V
H
I
T
A
V
A
V
E
Y
E
---
A
---
K
S
G
R
V
N
K
G
V
A
T
S
W
L
R
A
K
E
P
A
--R
A
----------
L
V
P
M
F
V
C
K
-------------
S
-
Q
F
R
L
P
F
K
S
-
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
----
A
W
L
-----
R
------
E
Q
-
G
K
E
V
G
E
T
L
L
Y
Y
G
A
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
-
G
-
A
L
T
Q
L
N
V
A
F
S
R
----
E
Q
A
-
H
----
K
V
Y
V
Q
H
L
L
K
R
D
--
R
-
E
H
L
W
K
L
I
-
H
-
E
-
G
G
A
H
I
Y
V
C
G
D
A
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
-
1
PsiBlast_PDB
76.25
41%
-86
- C2 -
1DDG
1
CYSJ_ECOLI
A:
[6-374]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
------------------
K
D
A
P
L
V
A
S
L
S
V
N
Q
K
I
T
-
G
R
N
S
E
K
D
V
R
H
I
E
I
D
L
G
D
-
S
G
L
-
R
Y
Q
P
G
D
A
L
G
V
W
Y
Q
N
D
P
A
L
V
K
E
L
V
E
L
L
--------------------------
W
L
K
G
D
E
P
--
V
T
V
----------
E
--------------------------
G
K
--------
T
----------
L
P
L
----
N
--
E
----
A
L
Q
W
H
F
E
L
T
-----
V
-----
N
T
A
N
-
I
-
V
E
N
Y
A
T
L
T
R
S
----
E
T
-------
L
L
P
L
V
G
D
----
K
A
K
L
Q
H
Y
--
A
A
T
------
T
P
I
V
D
M
V
R
-
F
S
---
P
A
Q
L
D
A
E
A
L
I
N
L
-
L
R
P
L
T
P
R
L
Y
S
I
A
S
S
Q
A
E
V
---
E
N
E
V
H
V
T
V
G
V
V
R
Y
D
---
V
---
E
-
G
R
A
R
A
G
G
A
S
S
F
L
A
D
R
V
E
E
E
G
------------
E
V
R
V
F
I
E
H
-------------
N
D
N
F
R
L
P
A
N
P
-
E
T
P
V
I
M
I
G
P
G
T
G
I
A
P
F
R
A
-----
F
M
-----
Q
Q
R
----
A
A
D
-----
E
------
A
P
-
G
K
----
N
W
L
F
F
G
N
P
H
F
T
E
D
F
L
Y
Q
V
E
W
Q
R
Y
V
K
E
-
G
-
V
L
T
R
I
D
L
A
W
S
R
----
D
Q
K
-
E
----
K
V
Y
V
Q
D
K
L
R
E
Q
--
G
-
A
E
L
W
R
W
I
-
N
-
D
-
G
A
H
-
I
Y
V
C
G
D
A
N
R
M
A
K
D
V
E
Q
A
L
L
E
V
I
A
E
F
G
G
M
D
T
E
A
A
D
E
F
L
S
E
L
R
V
E
R
R
Y
Q
R
D
V
Y
-
25
PsiBlast_CBE
76.12
31%
-74
- C2 -
1J9Z
3
NCPR_RAT
B:
[17-620]
---------------------------------------------------------------------------------
M
K
K
T
G
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
----
E
E
F
A
N
R
L
-
S
K
-
D
A
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
A
D
---
L
S
--
S
L
P
E
-----
I
DK
S
L
V
V
-
F
C
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
----------------
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
L
--
G
L
G
D
D
D
--
G
N
--
L
---
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
-------
C
E
F
---------
F
G
V
------
E
A
T
G
-----
E
E
S
S
IR-
Q
Y
E
L
----
V
V
------
H
--------
E
----
D
------
M
-
D
-------------
V
---------------
A
K
VYTGEMGRLKSYENQ
K
P
P
-------------------
F
D
------------------
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
Q
G
T
E
--
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
I
-
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
--------------------------
G
A
D
L
D
V
I
--
M
S
L
----------
N
------------------
N
------
L
D
E
ESNKKHPF
P
----------
C
P
T
----
T
Y
R
T
----
A
L
T
Y
Y
L
D
I
T
-----
N
PPR
T
N
V
L
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
----
E
H
-------
L
H
K
M
A
S
S
----
S
G
E
G
K
E
L
--
Y
L
S
WVVEAR
R
H
I
L
A
I
L
Q
D
Y
P
---
S
L
R
P
P
I
D
H
L
C
E
L
-
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
K
V
H
---
P
N
S
V
H
I
C
A
V
A
V
E
Y
E
---
A
---
K
S
G
R
V
N
K
G
V
A
T
S
W
L
R
A
K
E
P
A
G
-RA----------
L
V
P
M
F
V
R
K
-------------
S
-
Q
F
R
L
P
F
K
S
-
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
----
A
W
L
-----
R
------
E
Q
-
G
K
EV
G
E
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
-
G
-
A
L
T
Q
L
N
V
A
F
S
R
----
E
Q
A
-
H
----
K
V
Y
V
Q
H
L
L
K
R
D
--
R
-
E
H
L
W
K
L
I
-
H
-
E
-
G
G
A
H
I
Y
V
C
G
D
A
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
D
V
--
11
PsiBlast_PDB
75.35
30%
-74
- C2 -
3QFR
4
NCPR_HUMAN
A:
[14-617]
---------------------------------------------------------------------------------
M
K
K
T
G
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
----
E
E
F
A
N
R
L
-
S
K
-
D
A
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
A
D
---
L
S
--
S
L
P
E
-----
I
DN
A
L
V
V
-
F
C
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
----------------
L
S
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
K
R
L
E
Q
L
G
A
Q
R
I
F
E
L
--
G
L
G
D
D
D
--
G
N
--
L
---
E
E
D
F
I
T
W
-------
R
-------
E
Q
F
W
P
A
V
C
E
H
FG
V
E
A
------
T
G
E
E
-----
S
S
I
R
---
Q
Y
E
L
----
V
V
------
H
--------
T
----
D
------
I
-
D
-------------
A
---------------
A
K
VYMGEMGRLKSYENQ
K
P
P
-------------------
F
D
------------------
A
K
N
P
F
L
A
A
V
T
T
N
R
K
L
N
Q
G
T
E
--
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
I
-
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
L
G
K
I
L
--------------------------
G
A
D
L
D
V
V
--
M
S
L
----------
N
------------------
N
LDEESN
K
K
H
--------
P
----------
F
P
C
----
P
--
T
S
Y
R
T
A
L
T
Y
Y
L
D
I
T
-----
N
PPR
T
N
V
L
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
----
E
L
-------
L
R
K
M
A
S
S
----
S
G
E
G
K
E
L
--
Y
L
S
WVVEAR
R
H
I
L
A
I
L
Q
D
C
P
---
S
L
R
P
P
I
D
H
L
C
E
L
-
L
P
R
L
Q
A
H
Y
Y
S
I
A
S
S
S
K
V
H
---
P
N
S
V
H
I
C
A
V
V
V
E
Y
E
---
T
---
K
A
G
R
I
N
K
G
V
A
T
N
W
L
R
A
K
E
P
A
--------------
L
V
P
M
F
V
R
K
-------------
S
-
Q
F
R
L
P
F
K
A
-
T
T
P
V
I
M
V
G
P
G
T
G
V
A
P
F
I
G
-----
F
I
-----
Q
E
R
----
A
W
L
-----
R
------
Q
Q
-
G
K
E
V
G
E
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
Q
F
H
R
D
-
G
-
A
L
T
Q
L
N
V
A
F
S
R
----
E
Q
S
-
H
----
K
V
Y
V
Q
H
L
L
K
Q
D
--
R
-
E
H
L
W
K
L
I
-
E
-
G
-
G
A
H
-
I
Y
V
C
G
D
A
R
N
M
A
R
D
V
Q
N
T
F
Y
D
I
V
A
E
L
G
A
M
E
H
A
Q
A
V
D
Y
I
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
-
5
PsiBlast_PDB
74.51
30%
-78
- C2 -
1AMO
3
NCPR_RAT
A:
[10-614]
---------------------------------------------------------------------------------
M
K
K
T
G
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
----
E
E
F
A
N
R
L
-
S
K
-
D
A
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
A
D
---
L
S
--
S
L
P
E
-----
I
DK
S
L
V
V
-
F
C
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
----------------
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
L
--
G
L
G
D
D
D
--
G
N
--
L
---
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
-------
C
E
F
---------
F
G
V
------
E
A
-----------R--
Q
Y
E
L
----
V
V
------
H
--------
E
----
D
------
M
-
D
-------------
V
---------------
A
K
VYTGEMGRLKSYENQ
K
P
P
-------------------
F
D
------------------
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
Q
G
T
E
--
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
I
-
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
--------------------------
G
A
D
L
D
V
I
--
M
S
L
----------
N
------------------
N
------
L
D
E
ESNKKHPF
P
----------
C
P
T
----
T
Y
R
T
----
A
L
T
Y
Y
L
D
I
T
-----
N
PPR
T
N
V
L
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
----
E
H
-------
L
H
K
M
A
S
S
----
S
G
E
G
K
E
L
--
Y
L
S
WVVEAR
R
H
I
L
A
I
L
Q
D
Y
P
---
S
L
R
P
P
I
D
H
L
C
E
L
-
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
K
V
H
---
P
N
S
V
H
I
C
A
V
A
V
E
Y
E
---
A
---
K
S
G
R
V
N
K
G
V
A
T
S
W
L
R
A
K
E
P
A
--------------
L
V
P
M
F
V
R
K
-------------
S
-
Q
F
R
L
P
F
K
S
-
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
----
A
W
L
-----
R
------
E
Q
-
G
K
EV
G
E
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
-
G
-
A
L
T
Q
L
N
V
A
F
S
R
----
E
Q
A
-
H
----
K
V
Y
V
Q
H
L
L
K
R
D
--
R
-
E
H
L
W
K
L
I
-
H
-
E
-
G
G
A
H
I
Y
V
C
G
D
A
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
-
21
PsiBlast_CBE
74.44
41%
-84
- C2 -
1DDG
2
CYSJ_ECOLI
B:
[6-374]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
------------------
K
D
A
P
L
V
A
S
L
S
V
N
Q
K
I
T
-
G
R
N
S
E
K
D
V
R
H
I
E
I
D
L
G
D
-
S
G
L
-
R
Y
Q
P
G
D
A
L
G
V
W
Y
Q
N
D
P
A
L
V
K
E
L
V
E
L
L
--------------------------
W
L
K
G
D
E
P
--
V
T
V
----------
E
--------------------------
G
K
--------
T
----------
L
P
L
----
N
--
E
----
A
L
Q
W
H
F
E
L
T
-----
V
-----
N
T
A
N
-
I
-
V
E
N
Y
A
T
L
T
R
S
----
E
T
-------
L
L
P
L
V
G
D
----
K
A
K
L
Q
H
Y
--
A
A
T
------
T
P
I
V
D
M
V
R
-
F
S
---
P
A
Q
L
D
A
E
A
L
I
N
L
-
L
R
P
L
T
P
R
L
Y
S
I
A
S
S
Q
A
E
V
---
E
N
E
V
H
V
T
V
G
V
V
R
Y
D
---
V
---
E
-
G
R
A
R
A
G
G
A
S
S
F
L
A
D
R
V
E
E
E
G
------------
E
V
R
V
F
I
E
H
-------------
N
D
N
F
R
L
P
A
N
P
-
E
T
P
V
I
M
I
G
P
G
T
G
I
A
P
F
R
A
-----
F
M
-----
Q
Q
R
----
A
A
D
-----
E
------
A
P
-
G
K
----
N
W
L
F
F
G
N
P
H
F
T
E
D
F
L
Y
Q
V
E
W
Q
R
Y
V
K
E
-
G
-
V
L
T
R
I
D
L
A
W
S
R
----
D
Q
K
-
E
----
K
V
Y
V
Q
D
K
L
R
E
Q
--
G
-
A
E
L
W
R
W
I
-
N
-
D
-
G
A
H
-
I
Y
V
C
G
D
A
N
R
M
A
K
D
V
E
Q
A
L
L
E
V
I
A
E
F
G
G
M
D
T
E
A
A
D
E
F
L
S
E
L
R
V
E
R
R
Y
Q
R
D
V
Y
-
2
PsiBlast_PDB
74.14
41%
-81
- C2 -
1DDI
2
CYSJ_ECOLI
A:
[6-374]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
------------------
K
D
A
P
L
V
A
S
L
S
V
N
Q
K
I
T
-
G
R
N
S
E
K
D
V
R
H
I
E
I
D
L
G
D
-
S
G
L
-
R
Y
Q
P
G
D
A
L
G
V
W
Y
Q
N
D
P
A
L
V
K
E
L
V
E
L
L
--------------------------
W
L
K
G
D
E
P
--
V
T
V
----------
E
--------------------------
G
K
--------
T
----------
L
P
L
----
N
--
E
----
A
L
Q
W
H
F
E
L
T
-----
V
-----
N
T
A
N
-
I
-
V
E
N
Y
A
T
L
T
R
S
----
E
T
-------
L
L
P
L
V
G
D
----
K
A
K
L
Q
H
Y
--
A
A
T
------
T
P
I
V
D
M
V
R
-
F
S
---
P
A
Q
L
D
A
E
A
L
I
N
L
-
L
R
P
L
T
P
R
L
Y
S
I
A
S
S
Q
A
E
V
---
E
N
E
V
H
V
T
V
G
V
V
R
Y
D
---
V
---
E
-
G
R
A
R
A
G
G
A
S
S
F
L
A
D
R
V
E
E
E
G
------------
E
V
R
V
F
I
E
H
-------------
N
D
N
F
R
L
P
A
N
P
-
E
T
P
V
I
M
I
G
P
G
T
G
I
A
P
F
R
A
-----
F
M
-----
Q
Q
R
----
A
A
D
-----
E
------
A
P
-
G
K
----
N
W
L
F
F
G
N
P
H
F
T
E
D
F
L
Y
Q
V
E
W
Q
R
Y
V
K
E
-
G
-
V
L
T
R
I
D
L
A
W
S
R
----
D
Q
K
-
E
----
K
V
Y
V
Q
D
K
L
R
E
Q
--
G
-
A
E
L
W
R
W
I
-
N
-
D
-
G
A
H
-
I
Y
V
C
G
D
A
N
R
M
A
K
D
V
E
Q
A
L
L
E
V
I
A
E
F
G
G
M
D
T
E
A
A
D
E
F
L
S
E
L
R
V
E
R
R
Y
Q
R
D
V
Y
-
8
PsiBlast_PDB
73.13
31%
-76
- C2 -
1JA0
3
NCPR_RAT
A:
[17-620]
---------------------------------------------------------------------------------
M
K
K
T
G
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
----
E
E
F
A
N
R
L
-
S
K
-
D
A
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
A
D
---
L
S
--
S
L
P
E
-----
I
DK
S
L
V
V
-
F
C
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
----------------
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
L
--
G
L
G
D
D
D
--
G
N
--
L
---
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
-------
C
E
F
---------
F
G
V
------
E
A
T
G
-----
E
E
S
S
IR-
Q
Y
E
L
----
V
V
------
H
--------
E
----
D
------
M
-
D
-------------
V
---------------
A
K
VYTGEMGRLKSYE
N
Q
K
P
P
-------------------
F
D
------------------
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
Q
G
T
E
--
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
I
-
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
--------------------------
G
A
D
L
D
V
I
--
M
S
L
----------
N
------------------
N
LDEESN
K
K
H
--------
P
----------
F
P
C
----
P
--
T
T
Y
R
T
A
L
T
Y
Y
L
D
I
T
-----
N
PPR
T
N
V
L
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
----
E
H
-------
L
H
K
M
A
S
S
----
S
G
E
G
K
E
L
--
Y
L
S
WVVEAR
R
H
I
L
A
I
L
Q
D
Y
P
---
S
L
R
P
P
I
D
H
L
C
E
L
-
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
K
V
H
---
P
N
S
V
H
I
C
A
V
A
V
E
Y
E
---
A
---
K
S
G
R
V
N
K
G
V
A
T
S
W
L
R
A
K
E
P
A
--------------
L
V
P
M
F
V
R
K
-------------
S
-
Q
F
R
L
P
F
K
S
-
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
----
A
W
L
-----
R
------
E
Q
-
G
K
E
V
G
E
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
-
G
-
A
L
T
Q
L
N
V
A
F
S
R
----
E
Q
A
-
H
----
K
V
Y
V
Q
H
L
L
K
R
D
--
R
-
E
H
L
W
K
L
I
-
H
-
E
-
G
G
A
H
I
Y
V
C
G
D
A
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
D
V
--
80
HHSearch
73.07
32%
-79
- C2 -
3QFS
2
NCPR_HUMAN
A:
[54-457]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
P
-------------------
F
D
------------------
A
K
N
P
F
L
A
A
V
T
T
N
R
K
L
N
-
Q
G
-
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
I
-
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
L
G
K
I
L
--------------------------
G
A
D
L
D
V
V
--
M
S
L
N
N
LDEESNKK
H
------------------
P
------
F
P
C
--------
P
----------
T
S
Y
----
R
--
T
----
A
L
T
Y
Y
L
D
I
T
-----
N
-----
P
P
R
T
N
V
-
L
Y
E
L
A
Q
Y
A
S
E
P
S
E
Q
E
L
-------
L
R
K
M
A
S
S
S
G
E
G
K
E
L
Y
L
S
W
VV
E
A
R
------
R
H
I
L
A
I
L
Q
D
C
P
SL-
R
P
P
I
D
--
H
L
C
E
L
-
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
K
V
H
---
P
N
S
V
H
I
C
A
V
V
V
E
Y
E
T
--
K
---
A
-
G
R
I
N
K
G
V
A
T
N
W
L
R
A
K
E
P
V
G
E
NGG
R
A
-------
L
V
P
M
F
V
R
--------------
K
S
Q
F
R
L
P
F
K
A
-
T
T
P
V
I
M
V
G
P
G
T
G
V
A
P
F
I
G
-----
F
I
-----
Q
E
R
----
A
W
L
R
Q
Q
G-
K
------
E
V
-
G
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
Q
F
H
R
D
-
G
-
A
L
T
Q
L
N
V
A
F
S
R
----
E
Q
S
-
H
----
K
V
Y
V
Q
H
L
L
K
Q
D
--
R
-
E
H
L
W
K
L
I
-
E
-
G
-
G
A
H
-
I
Y
V
C
G
D
A
R
N
M
A
R
D
V
Q
N
T
F
Y
D
I
V
A
E
L
G
A
M
E
H
A
Q
A
V
D
Y
I
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
-
16
PsiBlast_PDB
70.92
31%
-82
- C2 -
3QFS
2
NCPR_HUMAN
A:
[61-457]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
F
L
A
A
V
T
T
N
R
K
L
N
Q
G
T
E
--
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
I
-
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
L
G
K
I
L
--------------------------
G
A
D
L
D
V
V
--
M
S
L
----------
N
------------------
N
LDEESN
K
K
H
--------
P
----------
F
P
C
----
P
--
T
S
Y
R
T
A
L
T
Y
Y
L
D
I
T
-----
N
PPR
T
N
V
L
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
----
E
L
-------
L
R
K
M
A
S
S
----
S
G
E
G
K
E
L
--
Y
L
S
WVVEAR
R
H
I
L
A
I
L
Q
D
C
P
---
S
L
R
P
P
I
D
H
L
C
E
L
-
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
K
V
H
---
P
N
S
V
H
I
C
A
V
V
V
E
Y
E
---
T
---
K
A
G
R
I
N
K
G
V
A
T
N
W
L
R
A
K
E
P
V
G
E
NGG
R
A
-------
L
V
P
M
F
V
R
K
-------------
S
-
Q
F
R
L
P
F
K
A
-
T
T
P
V
I
M
V
G
P
G
T
G
V
A
P
F
I
G
-----
F
I
-----
Q
E
R
----
A
W
L
-----
R
------
Q
Q
-
G
K
E
V
G
E
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
Q
F
H
R
D
-
G
-
A
L
T
Q
L
N
V
A
F
S
R
----
E
Q
S
-
H
----
K
V
Y
V
Q
H
L
L
K
Q
D
--
R
-
E
H
L
W
K
L
I
-
E
-
G
-
G
A
H
-
I
Y
V
C
G
D
A
R
N
M
A
R
D
V
Q
N
T
F
Y
D
I
V
A
E
L
G
A
M
E
H
A
Q
A
V
D
Y
I
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
-
17
PsiBlast_PDB
68.94
31%
-82
- C2 -
3QFT
2
NCPR_HUMAN
A:
[61-457]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
F
L
A
A
V
T
T
N
R
K
L
N
Q
G
T
E
--
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
I
-
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
L
G
K
I
L
--------------------------
G
A
D
L
D
V
V
--
M
S
L
----------
N
------------------
N
LDEESN
K
K
H
--------
P
----------
F
P
C
----
P
--
T
S
Y
R
T
A
L
T
Y
Y
L
D
I
T
-----
N
PPR
T
N
V
L
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
----
E
L
-------
L
R
K
M
A
S
S
----
S
G
E
G
K
E
L
--
Y
L
S
W
VVEAR
R
H
I
L
A
I
L
Q
D
C
P
---
S
L
R
P
P
I
D
H
L
C
E
L
-
L
P
R
L
Q
A
H
Y
Y
S
I
A
S
S
S
K
V
H
---
P
N
S
V
H
I
C
A
V
V
V
E
Y
E
---
T
---
K
A
G
R
I
N
K
G
V
A
T
N
W
L
R
A
K
E
P
V
--N
G
G
R
A
-------
L
V
P
M
F
V
R
K
-------------
S
-
Q
F
R
L
P
F
K
A
-
T
T
P
V
I
M
V
G
P
G
T
G
V
A
P
F
I
G
-----
F
I
-----
Q
E
R
----
A
W
L
-----
R
------
Q
Q
-
G
K
E
V
G
E
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
Q
F
H
R
D
-
G
-
A
L
T
Q
L
N
V
A
F
S
R
----
E
Q
S
-
H
----
K
V
Y
V
Q
H
L
L
K
Q
D
--
R
-
E
H
L
W
K
L
I
-
E
-
G
-
G
A
H
-
I
Y
V
C
G
D
A
R
N
M
A
R
D
V
Q
N
T
F
Y
D
I
V
A
E
L
G
A
M
E
H
A
Q
A
V
D
Y
I
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
-
24
PsiBlast_CBE
66.86
31%
-75
- C2 -
1JA0
2
NCPR_RAT
B:
[186-620]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IR-
Q
Y
E
L
----
V
V
------
H
--------
E
----
D
------
M
-
D
-------------
V
---------------
A
K
VYTGEMGRLKSYENQ
K
P
P
-------------------
F
D
------------------
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
Q
G
T
E
--
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
I
-
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
--------------------------
G
A
D
L
D
V
I
--
M
S
L
----------
N
------------------
N
LDEESN
K
K
H
--------
P
----------
F
P
C
----
P
--
T
T
Y
R
T
A
L
T
Y
Y
L
D
I
T
-----
N
PPR
T
N
V
L
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
----
E
H
-------
L
H
K
M
A
S
S
----
S
G
E
G
K
E
L
--
Y
L
S
WVVEAR
R
H
I
L
A
I
L
Q
D
Y
P
---
S
L
R
P
P
I
D
H
L
C
E
L
-
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
K
V
H
---
P
N
S
V
H
I
C
A
V
A
V
E
Y
E
---
A
---
K
S
G
R
V
N
K
G
V
A
T
S
W
L
R
A
K
E
P
A
G
-G
R
A
---------
L
V
P
M
F
V
R
K
-------------
S
-
Q
F
R
L
P
F
K
S
-
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
----
A
W
L
-----
R
------
E
Q
-
G
K
EV
G
E
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
-
G
-
A
L
T
Q
L
N
V
A
F
S
R
----
E
Q
A
-
H
----
K
V
Y
V
Q
H
L
L
K
R
D
--
R
-
E
H
L
W
K
L
I
-
H
-
E
-
G
G
A
H
I
Y
V
C
G
D
A
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
D
V
--
82
HHSearch
61.94
30%
-71
- C2 -
1F20
10
A:
[23-433]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
-------------------
V
H
------------------
K
K
R
V
S
A
A
R
L
L
S
R
Q
N
L
Q
-
S
P
K
S
S
R
S
T
I
F
V
R
L
H
T
N
G
N
Q
E
L
-
Q
Y
Q
P
G
D
H
L
G
V
F
P
G
N
H
E
D
L
V
N
A
L
I
E
R
L
--------------------------
E
D
A
P
P
A
N
H
V
V
K
V
----------
E
M
LEERNTALG
V
I
S
N
W
K
D
E
S
------
R
L
P
--------
P
----------
C
T
I
----
F
--
Q
----
A
F
K
Y
Y
L
D
I
T
-----
T
-----
P
P
T
P
L
Q
-
L
Q
Q
F
A
S
L
A
T
N
E
K
E
K
Q
R
-------
L
L
V
L
S
K
G
----
L
Q
E
Y
E
E
W
K
W
G
K
N
------
P
T
M
V
E
V
L
E
E
F
P
SI-
Q
M
P
A
T
--
L
L
L
T
Q
-
L
S
L
L
Q
P
R
Y
Y
S
I
S
S
S
P
D
M
Y
---
P
D
E
V
H
L
T
V
A
I
V
S
Y
H
T
--
R
DG-
E
-
G
P
V
H
H
G
V
C
S
S
W
L
N
R
I
Q
-
A
D
D
------------
V
V
P
C
F
V
R
G
-------------
A
P
S
F
H
L
P
R
N
P
-
Q
V
P
C
I
L
V
G
P
G
T
G
I
A
P
F
R
S
-----
F
W
-----
Q
Q
R
----
Q
F
D
I
QHKG
M
------
N
P
-
C
P
----
M
V
L
V
F
G
C
R
Q
S
K
I
D
H
I
Y
R
E
E
T
L
Q
A
K
N
K
-
G
-
V
F
R
E
L
Y
T
A
Y
S
R
----
E
P
D
R
P
----
K
K
Y
V
Q
D
V
L
Q
E
Q
L-
A
-
E
S
V
Y
R
A
L
-
K
E
Q
-
G
G
H
-
I
Y
V
C
G
D
V
-
T
M
A
A
D
V
L
K
A
I
Q
R
I
M
T
Q
Q
G
K
L
S
E
E
D
A
G
V
F
I
S
R
L
R
D
D
N
R
Y
H
E
D
I
F
-
30
PsiBlast_CBE
48.34
32%
-81
- C2 -
3VO1
1
?
A:
[93-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
L
G
D
FGD
S
K
T
V
S
L
C
V
K
R
L
V
Y
T
---
N
D--
Q
-
G
E
V
V
K
G
V
C
S
-
N
F
L
C
D
L
K
P
G
A
------------
E
V
K
I
T
G
P
V
-------------
G
K
E
M
L
M
P
K
D
P
-
N
A
T
I
I
M
L
A
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
E
H
----
E
D
Y
-----
K
------
Y
T
-
G
L
----
A
W
L
F
L
G
-
V
P
T
S
D
T
L
L
Y
K
E
E
L
E
K
M
K
E
M
-
A
P
D
N
F
R
L
D
F
A
V
S
R
----
E
Q
T
-
N
AAGE
K
M
Y
I
Q
T
R
M
A
E
Y
--
K
-
E
E
L
W
E
L
L
-
K
-
K
D
N
T
Y
-
V
Y
M
C
G
-
L
K
G
M
E
K
G
I
D
D
I
M
L
D
L
A
A
K
D
-
G
I
N
W
L
D
Y
K
---
K
Q
L
K
K
S
E
Q
W
N
V
E
V
Y
-
27
PsiBlast_CBE
45.92
31%
-78
- C2 -
3VO2
1
?
B:
[89-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
L
G
D
FGD
S
K
T
V
S
L
C
V
K
R
L
V
Y
T
---
N
D--
Q
-
G
E
I
V
K
G
V
C
S
-
N
F
L
C
D
L
K
P
G
A
------------
D
V
K
I
T
G
P
V
-------------
G
K
E
M
L
M
P
K
D
P
-
N
A
T
V
I
M
L
A
T
G
T
G
I
A
P
F
R
S
FLWKM
F
L
-----
E
E
H
----
E
D
Y
-----
K
------
F
S
-
G
L
----
A
W
L
F
L
G
-
V
P
T
S
D
S
L
L
Y
K
E
E
L
E
K
M
K
E
M
-
A
P
D
N
F
R
L
D
F
A
V
S
R
----
E
Q
T
-
N
AAGE
K
M
Y
I
Q
T
R
M
A
E
Y
--
R
-
E
E
L
W
E
L
L
-
K
-
K
D
N
T
Y
-
V
Y
M
C
G
-----
L
K
G
M
E
K
G
I
D
D
I
M
L
N
L
A
A
K
D
G
I
D
W
M
Q
Y
K
K
Q
L
K
K
G
E
Q
W
N
V
E
V
Y
-
29
PsiBlast_CBE
45.68
32%
-79
- C2 -
3VO1
1
?
B:
[93-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
L
G
D
FGD
S
K
T
V
S
L
C
V
K
R
L
V
Y
T
---
N
D--
Q
-
G
E
V
V
K
G
V
C
S
-
N
F
L
C
D
L
K
P
G
A
------------
E
V
K
I
T
G
P
V
-------------
G
K
E
M
L
M
P
K
D
P
-
N
A
T
I
I
M
L
A
T
G
T
G
I
A
P
F
R
S
-----
F
L
WKMFF
E
E
H
----
E
D
Y
-----
K
------
Y
T
-
G
L
----
A
W
L
F
L
G
-
V
P
T
S
D
T
L
L
Y
K
E
E
L
E
K
M
K
E
M
-
A
P
D
N
F
R
L
D
F
A
V
S
R
----
E
Q
T
-
N
AAGE
K
M
Y
I
Q
T
R
M
A
E
Y
--
K
-
E
E
L
W
E
L
L
-
K
-
K
D
N
T
Y
-
V
Y
M
C
G
-
L
K
G
M
E
K
G
I
D
D
I
M
L
D
L
A
A
K
D
-
G
I
N
W
L
D
Y
K
---
K
Q
L
K
K
S
E
Q
W
N
V
E
V
Y
-
28
PsiBlast_CBE
44.59
31%
-77
- C2 -
3VO2
1
?
A:
[89-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
L
G
D
FGD
S
K
T
V
S
L
C
V
K
R
L
V
Y
T
---
N
D--
Q
-
G
E
I
V
K
G
V
C
S
-
N
F
L
C
D
L
K
P
G
A
------------
D
V
K
I
T
G
P
V
-------------
G
K
E
M
L
M
P
K
D
P
-
N
A
T
V
I
M
L
A
T
G
T
G
I
A
P
F
R
S
F
L
W
K
M
F
L
-----
E
E
H
----
E
D
Y
-----
K
------
F
S
-
G
L
----
A
W
L
F
L
G
-
V
P
T
S
D
S
L
L
Y
K
E
E
L
E
K
M
K
E
M
-
A
P
D
N
F
R
L
D
F
A
V
S
R
----
E
Q
T
-
N
AAGE
K
M
Y
I
Q
T
R
M
A
E
Y
--
R
-
E
E
L
W
E
L
L
-
K
-
K
D
N
T
Y
-
V
Y
M
C
G
-----
L
K
G
M
E
K
G
I
D
D
I
M
L
N
L
A
A
K
D
G
I
D
W
M
Q
Y
K
K
Q
L
K
K
G
E
Q
W
N
V
E
V
Y
-
32
PsiBlast_CBE
43.01
32%
-82
- C2 -
1JB9
1
?
A:
[130-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
G
V
C
S
-
N
F
L
C
N
S
K
P
G
D
------------
K
I
Q
L
T
G
P
S
-------------
G
K
I
M
L
L
P
E
E
D
P
N
A
T
H
I
M
I
A
T
G
T
G
V
A
P
F
R
G
-----
Y
L
R
R
M
FM
E
D
V
----
P
N
Y
-----
R
------
F
G
-
G
L
----
A
W
L
F
L
G
V
A
N
-
S
D
S
L
L
Y
D
E
E
F
T
S
Y
L
K
Q
Y
P
-
D
N
F
R
Y
D
K
A
L
S
R
----
E
Q
K
--G---
K
M
Y
V
Q
D
K
I
E
E
Y
--
S
-
D
E
I
F
K
L
L
-
D
-
G
-
G
A
H
-
I
Y
F
C
G
-----
L
K
G
M
M
P
G
I
Q
D
T
L
K
K
V
A
E
R
R
G
E
S
W
D
Q
K
L
A
Q
L
K
K
N
K
Q
W
H
V
E
V
Y
-
31
PsiBlast_CBE
42.41
32%
-83
- C2 -
3LVB
1
?
A:
[125-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
G
V
C
S
-
N
F
L
C
N
S
K
P
G
D
------------
K
I
Q
L
T
G
P
S
-------------
G
K
I
M
L
L
P
E
E
D
P
N
A
T
H
I
M
I
A
T
G
T
G
V
A
P
F
R
G
-----
Y
L
R
R
M
FM
E
D
V
----
P
N
Y
-----
R
------
F
G
-
G
L
----
A
W
L
F
L
G
V
A
N
-
S
D
S
L
L
Y
D
E
E
F
T
S
Y
L
K
Q
Y
P
-
D
N
F
R
Y
D
K
A
L
S
R
----
E
Q
K
-
N
R
S
G
G
K
M
Y
V
Q
D
K
I
E
E
Y
--
S
-
D
E
I
F
K
L
L
-
D
-
G
-
G
A
H
-
I
Y
F
C
G
-----
L
K
G
M
M
P
G
I
Q
D
T
L
K
K
V
A
E
R
R
G
E
S
W
D
Q
K
L
A
Q
L
K
K
N
K
Q
W
H
V
E
V
Y
-
38
PsiBlast_CBE
41.49
32%
-80
- C2 -
1QGA
3
FENR1_PEA
A:
[87-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
I
G
D
FGD
S
K
T
V
S
L
C
V
K
R
L
V
Y
T
---
N
D--
A
-
G
E
V
V
K
G
V
C
S
-
N
F
L
C
D
L
K
P
G
S
------------
E
V
K
I
T
G
P
V
-------------
G
K
E
M
L
M
P
K
D
P
-
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
----
E
D
Y
-----
Q
------
F
N
-
G
L
----
A
W
L
F
L
G
V
P
T
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
-
P
-
E
N
F
R
L
D
F
A
V
S
R
EQVN
D
K
G
-
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
--
A
-
E
E
L
W
E
L
L
-
K
-
K
D
N
T
F
-
V
Y
M
C
G
-----
L
K
G
M
E
K
G
I
D
D
I
M
V
-----------------------------
36
PsiBlast_CBE
40.14
32%
-80
- C2 -
1QFY
3
FENR1_PEA
A:
[87-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
I
G
D
FGD
S
K
T
V
S
L
C
V
K
R
L
V
Y
T
---
N
D--
A
-
G
E
V
V
K
G
V
C
S
-
N
F
L
C
D
L
K
P
G
S
------------
E
V
K
I
T
G
P
V
-------------
G
K
E
M
L
M
P
K
D
P
-
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
----
E
D
Y
-----
Q
------
F
N
-
G
L
----
A
W
L
F
L
G
V
P
T
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
-
P
-
E
N
F
R
L
D
F
A
V
S
R
EQVN
D
K
G
-
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
--
A
-
E
E
L
W
E
L
L
-
K
-
K
D
N
T
F
-
V
Y
M
C
G
-----
L
K
G
M
E
K
G
I
D
D
I
M
V
-----------------------------
33
PsiBlast_CBE
40.10
32%
-77
- C2 -
1QFZ
2
FENR1_PEA
B:
[87-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
I
G
D
FGD
S
K
T
V
S
L
C
V
K
R
L
V
Y
T
---
N
D--
A
-
G
E
V
V
K
G
V
C
S
-
N
F
L
C
D
L
K
P
G
S
------------
E
V
K
I
T
G
P
V
-------------
G
K
E
M
L
M
P
K
D
P
-
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
----
E
D
Y
-----
Q
------
F
N
-
G
L
----
A
W
L
F
L
G
V
P
T
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
-
P
-
E
N
F
R
L
D
F
A
V
S
R
EQVN
D
K
G
-
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
--
A
-
E
E
L
W
E
L
L
-
K
-
K
D
N
T
F
-
V
Y
M
C
G
-----
L
K
G
M
E
K
G
I
D
D
I
M
V
-----------------------------
35
PsiBlast_CBE
40.06
32%
-79
- C2 -
1QFY
2
FENR1_PEA
B:
[87-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
I
G
D
FGD
S
K
T
V
S
L
C
V
K
R
L
V
Y
T
---
N
D--
A
-
G
E
V
V
K
G
V
C
S
-
N
F
L
C
D
L
K
P
G
S
------------
E
V
K
I
T
G
P
V
-------------
G
K
E
M
L
M
P
K
D
P
-
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
----
E
D
Y
-----
Q
------
F
N
-
G
L
----
A
W
L
F
L
G
V
P
T
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
-
P
-
E
N
F
R
L
D
F
A
V
S
R
EQVN
D
K
G
-
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
--
A
-
E
E
L
W
E
L
L
-
K
-
K
D
N
T
F
-
V
Y
M
C
G
-----
L
K
G
M
E
K
G
I
D
D
I
M
V
-----------------------------
34
PsiBlast_CBE
40.01
32%
-81
- C2 -
1QFZ
3
FENR1_PEA
A:
[87-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
I
G
D
FGD
S
K
T
V
S
L
C
V
K
R
L
V
Y
T
---
N
D--
A
-
G
E
V
V
K
G
V
C
S
-
N
F
L
C
D
L
K
P
G
S
------------
E
V
K
I
T
G
P
V
-------------
G
K
E
M
L
M
P
K
D
P
-
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
----
E
D
Y
-----
Q
------
F
N
-
G
L
----
A
W
L
F
L
G
V
P
T
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
-
P
-
E
N
F
R
L
D
F
A
V
S
R
EQVN
D
K
G
-
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
--
A
-
E
E
L
W
E
L
L
-
K
-
K
D
N
T
F
-
V
Y
M
C
G
-----
L
K
G
M
E
K
G
I
D
D
I
M
V
-----------------------------
37
PsiBlast_CBE
37.57
32%
-77
- C2 -
1QGA
2
FENR1_PEA
B:
[87-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
I
G
D
FGD
S
K
T
V
S
L
C
V
K
R
L
V
Y
T
---
N
D--
A
-
G
E
V
V
K
G
V
C
S
-
N
F
L
C
D
L
K
P
G
S
------------
E
V
K
I
T
G
P
V
-------------
G
K
E
M
L
M
P
K
D
P
-
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
----
E
D
Y
-----
Q
------
F
N
-
G
L
----
A
W
L
F
L
G
V
P
T
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
-
P
-
E
N
F
R
L
D
F
A
V
S
R
EQVN
D
K
G
-
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
--
A
-
E
E
L
W
E
L
L
-
K
-
K
D
N
T
F
-
V
Y
M
C
G
-----
L
K
G
M
E
K
G
I
D
D
I
M
V
-----------------------------