@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2427: (2016-04-04 )
MTEIQKPYDLKGRSLLKESDFTKAEFEGLIDFAITLKEYKKNGIKHHYLSGKNIALLFEKNSTRTRAAFTVASIDLGAHPEFLGKNDIQLGKKESVEDTAKVLGRMFDGIEFRGFSQQAVEDLAKFSGVPVWNGLTDDWHPTQMLADFMTIKENFGYLEGINLTYVGDGRNNIAHSLMVAGAMLGVNVRICTPKSLNPKEAYVDIAKEKASQYGGSIMITDNIAEAVENTDAIYTDVWVSMGEESEFEQRINLLKDYQVNQQMFDLTGKDSTIFLHCLPAFHDTNTLYGQEIYEKYGLAEMEVTDQIFRSEHSKVFDQAENRMHTIKAVMAATLGS
Atome Classification :
(40 SA)
.........10........20........30......-..40.-.......50-........60........70........80........90........100.......110.......120.......130.......140.......150...--.---.-..160.......170.......180.......190.......200.......210.......220.......230.......240-.....-...250.......260.....--..--270.......280.......290....-..-.300........310.......320.......330....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTEIQKPYDLK
G
R
S
LLKESDF
T
K
A
E
F
E
G
L
I
D
F
A
I
T
L
K
-
E
Y
K
KN-GIKHHYLSG-K
N
I
A
L
L
F
EKNST
R
T
R
A
A
F
T
V
A
S
I
DLGAH
P
E
FLGKNDIQLGKKE
S
V
E
D
T
A
K
V
L
G
R
M
FDGIEFRGF
S
Q
Q
A
V
E
D
L
A
K
FSGVPVWNGLTDDW
H
P
T
Q
M
L
A
D
F
M
T
I
K
E
NF--G---Y-LEG
I
N
L
T
Y
VGDGR
N
N
I
A
H
S
L
M
V
A
G
A
M
L
G
V
N
V
R
ICTPKSL
N
P
K
E
A
Y
V
D
I
A
K
E
K
A
S
QYG
G
S
I
M
I
T
D
N
I
A
E
A
V
ENTD
A
I
Y
T
D
V
W
VSM--G
E
E
S
E
-
F
E
Q
R
I
N
L
L
K
D
YQV
N
Q
Q
M
FDLT--GK--D
S
T
I
F
L
H
CLPAFHDTN
T
L
Y
G
Q
E
I
Y
E
K
Y-GL-A
E
-
M
E
V
T
D
Q
I
F
R
S
E
H
S
K
V
F
D
Q
A
EN
R
M
H
T
I
K
A
V
M
A
A
TLGS
1
PsiBlast_PDB
97.34
64%
-89
- C8 -
2W37
1
OTCC_LACHI
A:
[26-353]
---------
F
Q
G
R
S
V
L
A
E
K
D
F
S
A
A
E
L
E
Y
L
I
D
F
G
L
H
L
K
-
A
L
K
K
A
-
G
I
P
H
H
Y
L
E
G
-
K
N
I
A
L
L
F
E
K
S
S
T
R
T
R
S
A
F
T
T
A
S
I
D
L
G
A
H
P
E
Y
L
G
Q
N
D
I
Q
L
G
K
K
E
S
T
S
D
T
A
K
V
L
G
S
M
F
D
G
I
E
F
R
G
F
K
Q
S
D
A
E
I
L
A
R
D
S
G
V
P
V
W
N
G
L
T
D
E
W
H
P
T
Q
M
L
A
D
F
M
T
V
K
E
N
F
--
G
---
K
-
L
Q
G
L
T
L
T
F
M
G
D
G
R
N
N
V
A
N
S
L
L
V
T
G
A
I
L
G
V
N
I
H
I
V
A
P
K
A
L
F
P
T
E
E
T
Q
N
I
A
K
G
F
A
E
K
S
G
A
K
L
V
I
T
D
D
L
D
E
G
L
K
G
S
N
V
V
Y
T
D
V
W
V
S
M
--
G
-
E
S
N
-
W
E
E
R
V
K
E
L
T
P
Y
Q
V
N
M
E
A
M
K
K
T
--
G
T
PD
D
Q
L
I
F
M
H
C
L
P
A
F
H
N
T
D
T
Q
Y
G
K
E
I
K
E
K
Y
-
G
I
-
T
E
-
M
E
V
T
D
E
V
F
T
S
K
Y
A
R
Q
F
E
E
A
E
N
R
M
H
S
I
K
A
M
M
A
A
T
L
G
N
22
PsiBlast_CBE
97.07
64%
-90
- C8 -
2W37
1
OTCC_LACHI
B:
[26-353]
---------
F
Q
G
R
S
V
L
A
E
K
D
F
S
A
A
E
L
E
Y
L
I
D
F
G
L
H
L
K
-
A
L
K
K
A
-
G
I
P
H
H
Y
L
E
G
-
K
N
I
A
L
L
F
E
K
S
S
T
R
T
R
S
A
F
T
T
A
S
I
D
L
G
A
H
P
E
Y
L
G
Q
N
D
I
Q
L
G
K
K
E
S
T
S
D
T
A
K
V
L
G
S
M
F
D
G
I
E
F
R
G
F
K
Q
S
D
A
E
I
L
A
R
D
S
G
V
P
V
W
N
G
L
T
D
E
W
H
P
T
Q
M
L
A
D
F
M
T
V
K
E
N
F
--
G
---
K
-
L
Q
G
L
T
L
T
F
M
G
D
G
R
N
N
V
A
N
S
L
L
V
T
G
A
I
L
G
V
N
I
H
I
V
A
P
K
A
L
F
P
T
E
E
T
Q
N
I
A
K
G
F
A
E
K
S
G
A
K
L
V
I
T
D
D
L
D
E
G
L
K
G
S
N
V
V
Y
T
D
V
W
V
S
M
--
G
-
E
S
N
-
W
E
E
R
V
K
E
L
T
P
Y
Q
V
N
M
E
A
M
K
K
T
--
G
T
PD
D
Q
L
I
F
M
H
C
L
P
A
F
H
N
T
D
T
Q
Y
G
K
E
I
K
E
K
Y
-
G
I
-
T
E
-
M
E
V
T
D
E
V
F
T
S
K
Y
A
R
Q
F
E
E
A
E
N
R
M
H
S
I
K
A
M
M
A
A
T
L
G
N
101
HHSearch
96.99
63%
-88
- C8 -
2W37
1
OTCC_LACHI
A:
[19-352]
--
K
D
F
R
Q
N
V
F
Q
G
R
S
V
L
A
E
K
D
F
S
A
A
E
L
E
Y
L
I
D
F
G
L
H
L
K
-
A
L
K
K
A
-
G
I
P
H
H
Y
L
E
G
-
K
N
I
A
L
L
F
E
K
S
S
T
R
T
R
S
A
F
T
T
A
S
I
D
L
G
A
H
P
E
Y
L
G
Q
N
D
I
Q
L
G
K
K
E
S
T
S
D
T
A
K
V
L
G
S
M
F
D
G
I
E
F
R
G
F
K
Q
S
D
A
E
I
L
A
R
D
S
G
V
P
V
W
N
G
L
T
D
E
W
H
P
T
Q
M
L
A
D
F
M
T
V
K
E
N
F
--
G
---
K
-
L
Q
G
L
T
L
T
F
M
G
D
G
R
N
N
V
A
N
S
L
L
V
T
G
A
I
L
G
V
N
I
H
I
V
A
P
K
A
L
F
P
T
E
E
T
Q
N
I
A
K
G
F
A
E
K
S
G
A
K
L
V
I
T
D
D
L
D
E
G
L
K
G
S
N
V
V
Y
T
D
V
W
V
S
M
--
G
E
S
N
W
--
E
E
R
V
K
E
L
T
P
Y
Q
V
N
M
E
A
M
K
K
T
GT
P
D
--
D
Q
L
I
F
M
H
C
L
P
A
F
H
N
T
D
T
Q
Y
G
K
E
I
K
E
K
Y
-
G
I
-
T
E
-
M
E
V
T
D
E
V
F
T
S
K
Y
A
R
Q
F
E
E
A
E
N
R
M
H
S
I
K
A
M
M
A
A
T
L
G
-
21
PsiBlast_CBE
96.71
64%
-86
- C8 -
2W37
1
OTCC_LACHI
C:
[26-353]
---------
F
Q
G
R
S
V
L
A
E
K
D
F
S
A
A
E
L
E
Y
L
I
D
F
G
L
H
L
K
-
A
L
K
K
A
-
G
I
P
H
H
Y
L
E
G
-
K
N
I
A
L
L
F
E
K
S
S
T
R
T
R
S
A
F
T
T
A
S
I
D
L
G
A
H
P
E
Y
L
G
Q
N
D
I
Q
L
G
K
K
E
S
T
S
D
T
A
K
V
L
G
S
M
F
D
G
I
E
F
R
G
F
K
Q
S
D
A
E
I
L
A
R
D
S
G
V
P
V
W
N
G
L
T
D
E
W
H
P
T
Q
M
L
A
D
F
M
T
V
K
E
N
F
--
G
---
K
-
L
Q
G
L
T
L
T
F
M
G
D
G
R
N
N
V
A
N
S
L
L
V
T
G
A
I
L
G
V
N
I
H
I
V
A
P
K
A
L
F
P
T
E
E
T
Q
N
I
A
K
G
F
A
E
K
S
G
A
K
L
V
I
T
D
D
L
D
E
G
L
K
G
S
N
V
V
Y
T
D
V
W
V
S
M
--
G
-
E
S
N
-
W
E
E
R
V
K
E
L
T
P
Y
Q
V
N
M
E
A
M
K
K
T
--
G
T
PD
D
Q
L
I
F
M
H
C
L
P
A
F
H
N
T
D
T
Q
Y
G
K
E
I
K
E
K
Y
-
G
I
-
T
E
-
M
E
V
T
D
E
V
F
T
S
K
Y
A
R
Q
F
E
E
A
E
N
R
M
H
S
I
K
A
M
M
A
A
T
L
G
N
2
PsiBlast_PDB
91.75
51%
-88
- C8 -
3UPD
-
OTC_VIBVU
A:
[3-334]
-------
F
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
---
A
-
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
--
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
--
G
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
-
G
M
-
K
G
-
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
5
PsiBlast_PDB
91.16
51%
-83
- C8 -
4JHX
3
OTC_VIBVU
A:
[27-358]
-------
F
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
---
A
-
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
--
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
--
G
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
-
G
M
-
K
G
-
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
28
PsiBlast_CBE
90.87
51%
-88
- C8 -
4JHX
3
OTC_VIBVU
B:
[27-358]
-------
F
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
---
A
-
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
----------
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
--
G
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
-
G
M
-
K
G
-
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
23
PsiBlast_CBE
90.84
51%
-88
- C8 -
4KWT
3
OTC_VIBVU
C:
[27-358]
-------
F
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
---
A
-
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
--------
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
--
G
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
-
G
M
-
K
G
-
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
29
PsiBlast_CBE
90.59
51%
-88
- C8 -
4JFR
3
OTC_VIBVU
C:
[27-358]
-------
F
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
---
A
-
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
--
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
--
G
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
-
G
M
-
K
G
-
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
27
PsiBlast_CBE
90.55
51%
-88
- C8 -
4JHX
1
OTC_VIBVU
C:
[27-358]
-------
F
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
---
A
-
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
---------A
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
--
G
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
-
G
M
-
K
G
-
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
14
PsiBlast_PDB
90.40
47%
-93
- C8 -
1ORT
-
OTCC_PSEAE
A:
[2-333]
-------
F
N
M
H
N
R
N
L
L
S
L
M
H
H
S
T
R
E
L
R
Y
L
L
D
L
S
R
D
L
K
-
R
A
K
Y
T
-
G
T
E
Q
Q
H
L
K
R
-
K
N
I
A
L
I
F
E
K
T
S
T
R
T
R
C
A
F
E
V
A
A
Y
D
Q
G
A
N
V
T
Y
I
D
P
N
S
S
Q
I
G
H
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
A
I
G
Y
R
G
F
K
Q
E
I
V
E
E
L
A
K
F
A
G
V
P
V
F
N
G
L
T
D
E
Y
H
P
T
Q
M
L
A
D
V
L
T
M
R
E
H
S
--
D
---
K
P
L
H
D
I
S
Y
A
Y
L
G
D
A
R
N
N
M
G
N
S
L
L
L
I
G
A
K
L
G
M
D
V
R
I
A
A
P
K
A
L
W
P
H
D
E
F
V
A
Q
C
K
K
F
A
E
E
S
G
A
K
L
T
L
T
E
D
P
K
E
A
V
K
G
V
D
F
V
H
T
D
V
W
V
S
M
--
G
E
P
V
E
A
W
G
E
R
I
K
E
L
L
P
Y
Q
V
N
M
E
I
M
K
A
T
--
G
N
--
P
R
A
K
F
M
H
C
L
P
A
F
H
N
S
E
T
K
V
G
K
Q
I
A
E
Q
Y
P
N
L
-
A
N
G
I
E
V
T
E
D
V
F
E
S
P
Y
N
I
A
F
E
Q
A
E
N
R
M
H
T
I
K
A
I
L
V
S
T
L
A
-
24
PsiBlast_CBE
90.39
51%
-86
- C8 -
4KWT
1
OTC_VIBVU
B:
[27-358]
-------
F
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
---
A
-
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
----------
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
--
G
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
-
G
M
-
K
G
-
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
3
PsiBlast_PDB
90.04
51%
-84
- C8 -
4H31
14
OTC_VIBVU
A:
[27-357]
-------
F
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
---
A
-
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
--
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
--
G
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
-
G
M
-
K
G
-
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
-
13
PsiBlast_PDB
89.85
48%
-90
- C8 -
1DXH
3
OTCC_PSEAE
A:
[2-333]
-------
F
N
M
H
N
R
N
L
L
S
L
M
H
H
S
T
R
E
L
R
Y
L
L
D
L
S
R
D
L
K
-
R
A
K
Y
T
-
G
T
E
Q
Q
H
L
K
R
-
K
N
I
A
L
I
F
E
K
T
S
T
R
T
R
C
A
F
E
V
A
A
Y
D
Q
G
A
N
V
T
Y
I
D
P
N
S
S
Q
I
G
H
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
A
I
E
Y
R
G
F
K
Q
E
I
V
E
E
L
A
K
F
A
G
V
P
V
F
N
G
L
T
D
E
Y
H
P
T
Q
M
L
A
D
V
L
T
M
R
E
H
S
--
D
---
K
P
L
H
D
I
S
Y
A
Y
L
G
D
A
R
N
N
M
G
N
S
L
L
L
I
G
A
K
L
G
M
D
V
R
I
A
A
P
K
A
L
W
P
H
D
E
F
V
A
Q
C
K
K
F
A
E
E
S
G
A
K
L
T
L
T
E
D
P
K
E
A
V
K
G
V
D
F
V
H
T
D
V
W
V
S
M
--
G
E
P
V
E
A
W
G
E
R
I
K
E
L
L
P
Y
Q
V
N
M
E
I
M
K
A
T
--
G
N
--
P
R
A
K
F
M
H
C
L
P
A
F
H
N
S
E
T
K
V
G
K
Q
I
A
E
Q
Y
P
N
L
-
A
N
G
I
E
V
T
E
D
V
F
E
S
P
Y
N
I
A
F
E
Q
A
E
N
R
M
H
T
I
K
A
I
L
V
S
T
L
A
-
32
PsiBlast_CBE
89.80
51%
-82
- C8 -
4H31
12
OTC_VIBVU
B:
[27-357]
-------
F
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
---
A
-
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
--
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
--
G
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
-
G
M
-
K
G
-
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
-
25
PsiBlast_CBE
89.70
51%
-82
- C8 -
4JQO
6
OTC_VIBVU
C:
[27-358]
-------
F
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
---
A
-
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
--
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
--
G
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
-
G
M
-
K
G
-
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
36
PsiBlast_CBE
89.66
51%
-80
- C8 -
2OTC
2
OTC1_ECOLI
H:
[6-331]
------------
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
-
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
R
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
--
P
GK-
A
-
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
--
G
E
A
K
E
K
W
A
E
R
I
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
L
T
--
G
N
--
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
-
G
L
H
G
G
-
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--
6
PsiBlast_PDB
89.60
51%
-85
- C8 -
4JQO
8
OTC_VIBVU
A:
[27-358]
-------
F
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
---
A
-
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
--
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
--
G
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
-
G
M
-
K
G
-
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
4
PsiBlast_PDB
89.52
51%
-83
- C8 -
4JFR
2
OTC_VIBVU
A:
[27-358]
-------
F
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
---
A
-
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
--
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
--
G
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
-
G
M
-
K
G
-
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
30
PsiBlast_CBE
89.29
51%
-83
- C8 -
4JFR
3
OTC_VIBVU
B:
[27-358]
-------
F
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
---
A
-
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
--
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
--
G
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
-
G
M
-
K
G
-
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
34
PsiBlast_CBE
88.83
51%
-81
- C8 -
1DUV
2
OTC1_ECOLI
H:
[6-331]
------------
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
-
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
--
P
GK-
A
-
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
--
G
E
A
K
E
K
W
A
E
R
I
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
L
T
--
G
N
--
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
-
G
L
H
G
G
-
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--
8
PsiBlast_PDB
88.54
51%
-83
- C8 -
1DUV
3
OTC1_ECOLI
G:
[6-331]
------------
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
-
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
--
P
GK-
A
-
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
--
G
E
A
K
E
K
W
A
E
R
I
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
L
T
--
G
N
--
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
-
G
L
H
G
G
-
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--
33
PsiBlast_CBE
88.44
51%
-81
- C8 -
1DUV
2
OTC1_ECOLI
I:
[6-331]
------------
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
-
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
--
P
GK-
A
-
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
--
G
E
A
K
E
K
W
A
E
R
I
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
L
T
--
G
N
--
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
-
G
L
H
G
G
-
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--
26
PsiBlast_CBE
88.41
51%
-82
- C8 -
4JQO
6
OTC_VIBVU
B:
[27-358]
-------
F
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
---
A
-
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
--
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
--
G
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
-
G
M
-
K
G
-
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
105
HHSearch
82.74
39%
-85
- C8 -
1OTH
1
OTC_HUMAN
A:
[2-310]
-------
V
Q
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
-
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
--
S
---
S
-
L
K
G
L
T
L
S
W
I
G
D
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
--
G
R
E
E
E
-
K
K
K
R
L
Q
A
F
Q
G
Y
Q
V
T
M
K
T
A
K
V
A
---
A
--
S
D
W
T
F
L
H
C
L
P
R
K
--------------------
P
-
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
-
43
PsiBlast_CBE
82.19
42%
-83
- C8 -
4NF2
4
OTC_BACAN
C:
[29-331]
----
Q
V
P
-
K
L
N
T
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
-
K
N
K
Q
E
-
P
L
----
L
Q
G
-
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
T
--
N
---
T
-
F
K
G
I
K
L
A
Y
V
G
D
G
-
N
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
--
G
Q
E
G
E
--
E
E
K
Y
T
L
F
Q
P
Y
Q
I
N
K
E
L
V
K
-
H
--
A
K
--
Q
T
Y
H
F
L
H
C
L
P
A
H
R
-------------------
E
-
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
----
18
PsiBlast_PDB
81.73
42%
-83
- C8 -
4NF2
5
OTC_BACAN
A:
[29-331]
----
Q
V
P
-
K
L
N
T
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
-
K
N
K
Q
E
-
P
L
----
L
Q
G
-
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
T
--
N
---
T
-
F
K
G
I
K
L
A
Y
V
G
D
G
-
N
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
--
G
Q
E
G
E
--
E
E
K
Y
T
L
F
Q
P
Y
Q
I
N
K
E
L
V
K
-
H
--
A
K
--
Q
T
Y
H
F
L
H
C
L
P
A
H
R
-------------------
E
-
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
----
48
PsiBlast_CBE
81.24
37%
-84
- C8 -
1EP9
1
OTC_HUMAN
A:
[4-309]
---------
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
-
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
--
S
---
S
-
L
K
G
L
T
L
S
W
I
G
D
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
--
G
R
E
E
E
-
K
K
K
R
L
Q
A
F
Q
G
Y
Q
V
T
M
K
T
A
K
V
A
--
A
S
--
D
W
T
-
F
L
H
C
L
P
R
K
P
E
---------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
--
49
PsiBlast_CBE
80.88
37%
-83
- C8 -
1C9Y
2
OTC_HUMAN
A:
[4-309]
---------
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
-
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
--
S
---
S
-
L
K
G
L
T
L
S
W
I
G
D
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
--
G
R
E
E
E
-
K
K
K
R
L
Q
A
F
Q
G
Y
Q
V
T
M
K
T
A
K
V
A
--
A
S
--
D
W
T
-
F
L
H
C
L
P
R
K
P
E
---------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
--
45
PsiBlast_CBE
80.80
37%
-84
- C8 -
1OTH
1
OTC_HUMAN
A:
[4-309]
---------
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
-
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
--
S
---
S
-
L
K
G
L
T
L
S
W
I
G
D
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
--
G
R
E
E
E
-
K
K
K
R
L
Q
A
F
Q
G
Y
Q
V
T
M
K
T
A
K
V
A
--
A
S
--
D
W
T
-
F
L
H
C
L
P
R
K
P
E
---------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
--
44
PsiBlast_CBE
80.78
42%
-82
- C8 -
4NF2
5
OTC_BACAN
B:
[29-331]
----
Q
V
P
-
K
L
N
T
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
-
K
N
K
Q
E
-
P
L
----
L
Q
G
-
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
T
--
N
---
T
-
F
K
G
I
K
L
A
Y
V
G
D
G
-
N
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
--
G
Q
E
G
E
--
E
E
K
Y
T
L
F
Q
P
Y
Q
I
N
K
E
L
V
K
-
H
--
A
K
--
Q
T
Y
H
F
L
H
C
L
P
A
H
R
-------------------
E
-
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
----
46
PsiBlast_CBE
80.13
37%
-83
- C8 -
1FVO
1
OTC_HUMAN
B:
[4-309]
---------
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
-
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
--
S
---
S
-
L
K
G
L
T
L
S
W
I
G
D
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
--
G
R
E
E
E
-
K
K
K
R
L
Q
A
F
Q
G
Y
Q
V
T
M
K
T
A
K
V
A
--
A
S
--
D
W
T
-
F
L
H
C
L
P
R
K
P
E
---------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
--
47
PsiBlast_CBE
79.92
37%
-82
- C8 -
1FVO
1
OTC_HUMAN
A:
[4-309]
---------
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
-
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
--
S
---
S
-
L
K
G
L
T
L
S
W
I
G
D
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
--
G
R
E
E
E
-
K
K
K
R
L
Q
A
F
Q
G
Y
Q
V
T
M
K
T
A
K
V
A
--
A
S
--
D
W
T
-
F
L
H
C
L
P
R
K
P
E
---------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
--
55
PsiBlast_CBE
77.24
35%
-80
- C8 -
2I6U
5
OTC_MYCTU
C:
[3-300]
------------
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
---
A
-
E
L
K
K
D
-
P
V
S
R
R
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
--
G
---
A
-
L
R
G
L
R
L
S
Y
F
G
D
G
A
N
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
--
G
Q
E
N
D
-
G
L
D
R
V
K
P
F
R
P
F
Q
L
N
S
R
L
L
A
L
A
--
D
S
--
D
A
-
I
V
L
H
C
L
P
A
H
R
G
D
--------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
------
72
PsiBlast_CBE
77.06
33%
-79
- C8 -
4A8T
3
PTC_ENTFA
A:
[25-328]
------------
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
-
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
-
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
-
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
--
P
EGK
K
-
L
E
D
C
K
V
V
F
V
G
D
A
-
T
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
-
A
S
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
YE
A
E
L
S
E
-
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
R
A
--
G
A
--
N
C
K
-
F
M
H
C
L
P
A
T
R
G
E
--------------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
-----
57
PsiBlast_CBE
76.24
35%
-79
- C8 -
2I6U
5
OTC_MYCTU
A:
[3-300]
------------
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
---
A
-
E
L
K
K
D
-
P
V
S
R
R
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
--
G
---
A
-
L
R
G
L
R
L
S
Y
F
G
D
G
A
N
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
--
G
Q
E
N
D
-
G
L
D
R
V
K
P
F
R
P
F
Q
L
N
S
R
L
L
A
L
A
--
D
S
--
D
A
-
I
V
L
H
C
L
P
A
H
R
G
D
--------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
------
56
PsiBlast_CBE
75.88
35%
-78
- C8 -
2I6U
5
OTC_MYCTU
B:
[3-300]
------------
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
---
A
-
E
L
K
K
D
-
P
V
S
R
R
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
--
G
---
A
-
L
R
G
L
R
L
S
Y
F
G
D
G
A
N
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
--
G
Q
E
N
D
-
G
L
D
R
V
K
P
F
R
P
F
Q
L
N
S
R
L
L
A
L
A
--
D
S
--
D
A
-
I
V
L
H
C
L
P
A
H
R
G
D
--------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
------
70
PsiBlast_CBE
75.53
34%
-77
- C8 -
4A8H
6
PTC_ENTFA
B:
[3-305]
------------
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
-
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
-
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
--
P
EGK
K
-
L
E
D
C
K
V
V
F
V
G
D
A
-
T
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
-
A
S
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
YE
A
E
L
S
E
-
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
R
A
--
G
A
--
N
C
K
-
F
M
H
C
L
P
A
T
R
G
E
--------------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
------
71
PsiBlast_CBE
75.39
34%
-75
- C8 -
4A8H
6
PTC_ENTFA
A:
[3-305]
------------
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
-
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
-
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
--
P
EGK
K
-
L
E
D
C
K
V
V
F
V
G
D
A
-
T
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
-
A
S
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
YE
A
E
L
S
E
-
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
R
A
--
G
A
--
N
C
K
-
F
M
H
C
L
P
A
T
R
G
E
--------------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
------
107
HHSearch
74.87
36%
-77
- C8 -
2I6U
5
OTC_MYCTU
A:
[2-306]
-----------
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
-
K
D
P
V
S
---
R
R
P
L
Q
G
P
-
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
--
G
---
A
-
L
R
G
L
R
L
S
Y
F
G
D
G
A
N
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
--
G
Q
E
N
D
-
G
L
D
R
V
K
P
F
R
P
F
Q
L
N
S
R
L
L
A
L
A
---
D
--
S
D
A
I
V
L
H
C
L
P
A
H
-------------------
R
G
-
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R