@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2492: (2016-04-04 )
MTILSVQHVSKTYGKKHTFQALKDINFDIQKGEFVAIMGPSGSGKTTLLNVLSSIDQISSGSVIANGQELNKLNQKALAKFRKESLGFIFQDYSILPTLTVKENIMLPLSVQKMSKATMEENYKAITTALGIYDLGNKYPSELSGGQQQRTAAARAFVHKPQIIFADEPTGALDSKSANDLLQRLEEMNKSFDTTIVMVTHDPVAASFAERVIMLKDGQIHTQLYQEGRSKQAFYEDIVHLQSVLGGVSNDI
Atome Classification :
(41 SA)
.........10...-.-....20........30........40........50........60........70---------........80........90........100....-.-..110.......120.......130--......-..----140-------.......150.......160.......170.......180.......190.......200-..-..-...210.......220........230.......240.......250
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
I
L
S
V
Q
H
V
S
K
TYG-K-
K
H
T
F
Q
A
L
K
DIN
F
D
IQKG
E
F
V
A
I
MGPSGSG
K
T
T
L
L
N
V
L
S
S
I
D
Q
ISSG
S
V
I
AN
G
Q
E
L
N
---------
K
L
N
Q
K
A
L
A
K
F
R
K
E
S
L
G
F
I
F
QDYSIL
P
T
L
T
VKEN
I
M
-L-P
L
S
V
Q
K
M
S
K
A
T
M
E
E
N
Y
K
A
I
T
T
A
L
G
---
I
Y
D
L
GN-KY----
P
S
E-------LSG
G
Q
Q
Q
R
T
A
A
A
R
A
FVHKP
Q
I
I
F
ADEPTGALDSK
S
A
N
D
L
L
Q
R
L
E
E
M
NKSF
D
T
T
I
V
M
V
THD-
P
V
-
A
A
-
S
F
A
E
R
V
I
M
LKDG
Q
I
-
H
T
Q
L
Y
Q
EGRS
K
Q
A
F
Y
E
D
I
V
H
L
Q
S
V
L
G
GVSNDI
3
PsiBlast_PDB
91.90
41%
-101
- C1 -
1F3O
2
Y796_METJA
A:
[2-226]
---
I
K
L
K
N
V
T
K
T
Y
K
-
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
---------
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
-
L
-
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
---
M
A
E
L
E
E
-
R
F
ANHK
P
N
Q
-------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
-
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-
E
R
E
-----------------------------
21
PsiBlast_CBE
90.74
41%
-106
- C1 -
1L2T
4
Y796_METJA
B:
[1-226]
--
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
-
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
---------
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
-
L
-
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
---
M
A
E
L
E
E
-
R
F
ANHK
P
N
Q
-------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
-
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-
E
R
E
-----------------------------
1
PsiBlast_PDB
89.85
41%
-103
- C1 -
1L2T
4
Y796_METJA
A:
[1-226]
--
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
-
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
---------
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
-
L
-
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
---
M
A
E
L
E
E
-
R
F
ANHK
P
N
Q
-------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
-
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-
E
R
E
-----------------------------
2
PsiBlast_PDB
88.85
41%
-101
- C1 -
3TIF
7
Y796_METJA
A:
[1-226]
--
M
V
K
L
K
N
V
T
K
T
Y
K
-
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
---------
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
-
L
-
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
---
M
A
E
L
E
E
-
R
F
ANHK
P
N
Q
-------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
-
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-
E
R
E
-----------------------------
22
PsiBlast_CBE
88.73
41%
-106
- C1 -
3TIF
7
Y796_METJA
B:
[1-226]
--
M
V
K
L
K
N
V
T
K
T
Y
K
-
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
---------
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
-
L
-
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
---
M
A
E
L
E
E
-
R
F
ANHK
P
N
Q
-------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
-
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-
E
R
E
-----------------------------
116
HHSearch
77.55
38%
-94
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[2-222]
A
E
I
L
R
A
E
N
I
K
K
V
I
R
-
G
----
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
---------
Y
T
N
E
K
E
L
S
L
L
R
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
-
V
-
P
M
L
K
M
G
K
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
---
L
G
D
K
L
S
-
R
K
----
P
Y
E
-------
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
E
-
G
G
T
S
I
V
M
V
T
H
E
-
R
E
-
L
A
-
E
L
T
H
R
T
L
E
M
K
D
G
K
V
-
V
G
E
I
T
---------------------------
19
PsiBlast_PDB
75.83
34%
-86
- C1 -
1OXV
7
?
A:
[1-236]
M
V
R
I
I
V
K
N
V
S
K
V
F
--
K
-
K
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
-
L
V
---------
A
S
N
G
K
L
I
V
P
P
E
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
-
F
-
P
L
T
N
M
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
---
I
H
H
V
L
N
-
H
F
----
P
R
E
-------
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
-
P
A
-
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
-----
K
L
V
Q
V
G
K
P
-
E
D
L
Y
D
N
P
V
S
I
Q
----------
26
PsiBlast_CBE
75.64
35%
-94
- C1 -
4U02
1
?
B:
[4-226]
--
I
I
R
I
R
N
L
H
K
W
F
G
-
P
-
L
H
V
---
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
--
L
S
---------
V
K
D
D
R
A
L
R
E
I
R
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
-
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
---
I
L
D
Q
A
R
-
K
Y
----
P
A
Q
-------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
-----
V
E
E
G
R
P
E
E
I
F
------------------
23
PsiBlast_CBE
75.41
38%
-97
- C1 -
2PCJ
1
LOLD_AQUAE
B:
[4-217]
--
I
L
R
A
E
N
I
K
K
V
I
-----
R
G
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
---------
Y
T
N
E
K
E
L
S
L
L
R
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
-
V
-
P
M
L
K
M
G
K
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
---
L
G
D
K
L
S
-
R
K
----
P
Y
E
-------
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
E
G
-
G
T
S
I
V
M
V
T
H
E
-
R
E
-
L
A
-
E
L
T
H
R
T
L
E
M
K
D
G
K
V
---------------------------------
6
PsiBlast_PDB
75.20
35%
-95
- C1 -
4U00
3
?
A:
[4-226]
--
I
I
R
I
R
N
L
H
K
W
F
G
-
P
-
L
H
V
---
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
--
L
S
---------
V
K
D
D
R
A
L
R
E
I
R
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
-
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
---
I
L
D
Q
A
R
-
K
Y
----
P
A
Q
-------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
-----
V
E
E
G
R
P
E
E
I
F
------------------
30
PsiBlast_CBE
75.04
34%
-88
- C1 -
1OXV
15
?
D:
[1-236]
M
V
R
I
I
V
K
N
V
S
K
V
F
--
K
-
K
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
-
L
V
---------
A
S
N
G
K
L
I
V
P
P
E
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
-
F
-
P
L
T
N
M
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
---
I
H
H
V
L
N
-
H
F
----
P
R
E
-------
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
-
P
A
-
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
-----
K
L
V
Q
V
G
K
P
-
E
D
L
Y
D
N
P
V
S
I
Q
----------
18
PsiBlast_PDB
74.90
34%
-88
- C1 -
1OXU
7
?
A:
[1-236]
M
V
R
I
I
V
K
N
V
S
K
V
F
--
K
-
K
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
-
L
V
---------
A
S
N
G
K
L
I
V
P
P
E
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
-
F
-
P
L
T
N
M
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
---
I
H
H
V
L
N
-
H
F
----
P
R
E
-------
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
-
P
A
-
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
-----
K
L
V
Q
V
G
K
P
-
E
D
L
Y
D
N
P
V
S
I
Q
----------
25
PsiBlast_CBE
74.82
35%
-98
- C1 -
4U02
1
?
C:
[4-226]
--
I
I
R
I
R
N
L
H
K
W
F
G
-
P
-
L
H
V
---
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
--
L
S
---------
V
K
D
D
R
A
L
R
E
I
R
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
-
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
---
I
L
D
Q
A
R
-
K
Y
----
P
A
Q
-------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
-----
V
E
E
G
R
P
E
E
I
F
------------------
4
PsiBlast_PDB
74.29
38%
-95
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[4-217]
--
I
L
R
A
E
N
I
K
K
V
I
-----
R
G
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
---------
Y
T
N
E
K
E
L
S
L
L
R
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
-
V
-
P
M
L
K
M
G
K
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
---
L
G
D
K
L
S
-
R
K
----
P
Y
E
-------
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
E
G
-
G
T
S
I
V
M
V
T
H
E
-
R
E
-
L
A
-
E
L
T
H
R
T
L
E
M
K
D
G
K
V
---------------------------------
24
PsiBlast_CBE
73.98
35%
-89
- C1 -
4U02
1
?
D:
[4-226]
--
I
I
R
I
R
N
L
H
K
W
F
G
-
P
-
L
H
V
---
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
--
L
S
---------
V
K
D
D
R
A
L
R
E
I
R
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
-
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
---
I
L
D
Q
A
R
-
K
Y
----
P
A
Q
-------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
-----
V
E
E
G
R
P
E
E
I
F
------------------
5
PsiBlast_PDB
73.69
38%
-96
- C1 -
2PCL
12
LOLD_AQUAE
A:
[4-217]
--
I
L
R
A
E
N
I
K
K
V
I
-----
R
G
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
---------
Y
T
N
E
K
E
L
S
L
L
R
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
-
V
-
P
M
L
K
M
G
K
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
---
L
G
D
K
L
S
-
R
K
----
P
Y
E
-------
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
E
G
-
G
T
S
I
V
M
V
T
H
E
-
R
E
-
L
A
-
E
L
T
H
R
T
L
E
M
K
D
G
K
V
---------------------------------
109
HHSearch
73.61
31%
-101
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-221]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
-
E
----
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
---------
D
T
P
P
------
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
---
L
A
H
L
L
D
-
R
K
----
P
K
A
-------
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
-
Q
V
-
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
-
A
Q
V
G
K
P
L
E
L
-----------------------
7
PsiBlast_PDB
73.61
35%
-91
- C1 -
4U02
1
?
A:
[4-226]
--
I
I
R
I
R
N
L
H
K
W
F
G
-
P
-
L
H
V
---
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
--
L
S
---------
V
K
D
D
R
A
L
R
E
I
R
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
-
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
---
I
L
D
Q
A
R
-
K
Y
----
P
A
Q
-------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
-----
V
E
E
G
R
P
E
E
I
F
------------------
32
PsiBlast_CBE
73.07
34%
-86
- C1 -
1OXU
13
?
C:
[1-236]
M
V
R
I
I
V
K
N
V
S
K
V
F
--
K
-
K
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
-
L
V
---------
A
S
N
G
K
L
I
V
P
P
E
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
-
F
-
P
L
T
N
M
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
---
I
H
H
V
L
N
-
H
F
----
P
R
E
-------
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
-
P
A
-
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
-----
K
L
V
Q
V
G
K
P
-
E
D
L
Y
D
N
P
V
S
I
Q
----------
13
PsiBlast_PDB
72.94
35%
-101
- C1 -
4YMU
2
?
J:
[1-225]
--
M
I
F
V
N
D
V
Y
K
N
F
G
-----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
-----------
N
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
---
L
L
D
K
K
D
-
Q
Y
----
P
I
K
-------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
G
D
R
V
I
F
M
D
D
G
V
I
-----
V
E
E
G
T
P
E
E
I
F
Y
-----------------
29
PsiBlast_CBE
72.33
35%
-99
- C1 -
4YMU
2
?
A:
[1-225]
--
M
I
F
V
N
D
V
Y
K
N
F
G
-----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
-----------
N
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
---
L
L
D
K
K
D
-
Q
Y
----
P
I
K
-------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
G
D
R
V
I
F
M
D
D
G
V
I
-----
V
E
E
G
T
P
E
E
I
F
Y
-----------------
84
PsiBlast_CBE
72.04
33%
-87
- C1 -
2HYD
3
Y1866_STAAM
A:
[340-578]
---
I
D
I
D
H
V
S
F
Q
Y
N
-
D
-
N
E
A
-
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
---------
D
F
L
T
G
S
L
----
R
N
Q
I
G
L
V
Q
Q
D
-
N
I
L
F
S
D
T
V
K
E
N
I
L
-
L
------
G
R
P
T
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
-
G
Y
----
D
T
E
VGERGVK
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
--
D
R
T
T
L
I
V
A
H
R
-
L
S
-
T
I
-
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
--------
87
PsiBlast_CBE
71.69
32%
-95
- C1 -
1B0U
4
HISP_SALTY
A:
[7-241]
---
L
H
V
I
D
L
H
K
R
Y
G
-----
G
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
KDGQL
K
V
A
D
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
-
P
I
Q
V
L
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
---
I
D
E
R
A
Q
G
K
Y
----
P
V
H
-------
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
-
E
----
E
E
G
D
P
E
Q
V
F
------------------
85
PsiBlast_CBE
71.66
34%
-89
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[5-217]
---
L
H
I
G
H
L
S
K
S
F
-----
Q
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
---------
S
K
N
T
N
L
--
P
V
R
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
-
Y
-
G
L
G
N
G
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
---
I
S
E
L
A
G
-
R
Y
----
P
H
E
-------
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
-
A
L
-
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
---------------------------------
46
PsiBlast_CBE
71.28
34%
-100
- C1 -
2OLK
1
?
C:
[22-247]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
---
L
K
D
K
A
H
-
A
Y
----
P
D
S
-------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
E
G
K
P
E
D
L
F
------------------
86
PsiBlast_CBE
71.24
34%
-91
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[5-222]
---
L
H
I
G
H
L
S
K
S
F
-----
Q
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
---------
S
K
N
T
N
L
--
P
V
R
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
-
Y
-
G
L
G
N
G
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
---
I
S
E
L
A
G
-
R
Y
----
P
H
E
-------
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
-
A
L
-
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
---------------------------------
28
PsiBlast_CBE
71.24
35%
-98
- C1 -
4YMV
1
?
A:
[1-225]
--
M
I
F
V
N
D
V
Y
K
N
F
G
-----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
-----------
N
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
---
L
L
D
K
K
D
-
Q
Y
----
P
I
K
-------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
G
D
R
V
I
F
M
D
D
G
V
I
-----
V
E
E
G
T
P
E
E
I
F
Y
-----------------
14
PsiBlast_PDB
70.84
35%
-98
- C1 -
4YMV
1
?
J:
[1-225]
--
M
I
F
V
N
D
V
Y
K
N
F
G
-----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
-----------
N
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
---
L
L
D
K
K
D
-
Q
Y
----
P
I
K
-------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
G
D
R
V
I
F
M
D
D
G
V
I
-----
V
E
E
G
T
P
E
E
I
F
Y
-----------------
83
PsiBlast_CBE
70.63
33%
-88
- C1 -
2HYD
3
Y1866_STAAM
B:
[340-578]
---
I
D
I
D
H
V
S
F
Q
Y
N
-
D
-
N
E
A
-
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
---------
D
F
L
T
G
S
L
----
R
N
Q
I
G
L
V
Q
Q
D
-
N
I
L
F
S
D
T
V
K
E
N
I
L
-
L
------
G
R
P
T
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
HDF
I
M
N
L
P
Q
-
G
Y
----
D
T
E
VGERGVK
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
--
D
R
T
T
L
I
V
A
H
R
-
L
S
-
T
I
-
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
--------
48
PsiBlast_CBE
69.65
34%
-98
- C1 -
2OLK
1
?
A:
[22-247]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
---
L
K
D
K
A
H
-
A
Y
----
P
D
S
-------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
E
G
K
P
E
D
L
F
------------------
47
PsiBlast_CBE
69.16
34%
-95
- C1 -
2OLK
2
?
B:
[22-247]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
---
L
K
D
K
A
H
-
A
Y
----
P
D
S
-------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
E
G
K
P
E
D
L
F
------------------
45
PsiBlast_CBE
67.82
34%
-95
- C1 -
2OLK
1
?
D:
[22-247]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
---
L
K
D
K
A
H
-
A
Y
----
P
D
S
-------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
E
G
K
P
E
D
L
F
------------------
50
PsiBlast_CBE
67.67
34%
-101
- C1 -
2OLJ
4
?
A:
[22-247]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
---
L
K
D
K
A
H
-
A
Y
----
P
D
S
-------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
E
G
K
P
E
D
L
F
------------------
37
PsiBlast_CBE
67.40
34%
-101
- C1 -
3C4J
4
?
B:
[22-247]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
---
L
K
D
K
A
H
-
A
Y
----
P
D
S
-------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
E
G
K
P
E
D
L
F
------------------
38
PsiBlast_CBE
65.92
34%
-94
- C1 -
3C4J
3
?
A:
[22-247]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
---
L
K
D
K
A
H
-
A
Y
----
P
D
S
-------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
E
G
K
P
E
D
L
F
------------------
36
PsiBlast_CBE
65.78
34%
-91
- C1 -
3C41
3
?
J:
[1-226]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
---
L
K
D
K
A
H
-
A
Y
----
P
D
S
-------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
E
G
K
P
E
D
L
F
------------------
35
PsiBlast_CBE
65.72
34%
-94
- C1 -
3C41
3
?
K:
[1-226]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
---
L
K
D
K
A
H
-
A
Y
----
P
D
S
-------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
E
G
K
P
E
D
L
F
------------------
40
PsiBlast_CBE
64.89
34%
-93
- C1 -
2Q0H
4
?
A:
[23-247]
-
Q
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
---
L
K
D
K
A
H
-
A
Y
----
P
D
S
-------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
E
G
K
P
E
D
L
F
------------------
34
PsiBlast_CBE
63.23
31%
-96
- C1 -
1VCI
1
?
A:
[10-227]
M
V
E
V
K
L
E
N
L
T
K
R
F
G
-----
N
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
T
---------
Y
L
P
P
K
------
D
R
N
I
S
M
V
F
Q
------
H
M
T
V
Y
E
N
I
A
-
F
-
P
L
--
K
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
---
I
E
E
L
L
N
-
R
Y
----
P
A
Q
-------
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
-
Q
V
E
A
M
-
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
---------------------------------
39
PsiBlast_CBE
62.85
34%
-95
- C1 -
2Q0H
4
?
B:
[22-247]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
---
L
K
D
K
A
H
-
A
Y
----
P
D
S
-------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
E
G
K
P
E
D
L
F
------------------
49
PsiBlast_CBE
62.81
34%
-87
- C1 -
2OLJ
3
?
B:
[22-247]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
---
L
K
D
K
A
H
-
A
Y
----
P
D
S
-------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
E
G
K
P
E
D
L
F
------------------