@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SAP008: (2016-04-04 )
MFNAVVVRKSASNVSYKVEKVDESHLSKGDVLVKVVYSSINYKDMLALQYKGGVIRDYPMIPGIDFAGIVESSSNDKFKEGDNVLVTGYDVGVTHTGGFSEYAQVPGEWIVPIPQEMSIKESMVYGTAGFTAALSIFELEKYGMNIKSQPEILVSGATGGVGSVAIQILHKIGYENITAIVRKEKQIEIAKKLGAKQVIIIEDDNKPLKKGIFDYFLDTVGSNVTLYGLKRLNYQGVATVCGNVAGNSLNANILPFILRGIKLIGIDSVYVDHNIREDIWSKLANEWNIGNSLLYNEIGFEEFYKTIDQLLKGQHLGRTILKV
Atome Classification :
(20 SA)
.........10...-.....20........30........40........50...-------.....60........70...--.--....80...--------------.....----------------------90-----------------------------------------......--------...100.......110.......120.......130--.......140.....-.-.150.......160.......170.-......180....----...190.......--200.------.-------..--...210.......220--.......230..-.--------....240......-.250..-.....260.......270---.-.......280..-.....290--..---...---...300.......310.......320.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MF
N
A
V
V
V
RKSASN
V
-
S
Y
K
V
E
KV
D
E
S
HLSKG
D
V
L
V
K
V
V
Y
SSI
N
Y
K
D
M
L
A
L
Q
YKGGV-------IRDYPMIPGID
F
A
G
I
VESSS--N--DKFKEGD
N
V
--------------
L
V
T
G
Y
----------------------D------------------------------------------VG
V
T
HT--------GG
F
S
E
Y
A
QVPG
E
W
IVPI
P
Q
EM
S
I
K
E
S
M
V
YGTA
G
F
T
A
--
A
L
S
I
F
E
L
E
K
YGMNIK-S-QP
E
I
L
V
SGATG
G
V
G
S
V
A
I
Q
I
L
H
K
IG-
Y
E
N
I
T
A
I
V
R
K
E
K
Q
----
I
E
I
A
K
KLGA
K
Q
V
I
--
I
I
ED------D-------NK--
P
L
K
K
G
I
F
D
Y
F
L
D
T
VGS--N
V
T
L
Y
G
L
KRLNY-
Q
--------
G
V
A
T
V
C
G
N
VAGNS-LNA
N
I
L
-
P
F
I
L
RG
I
K
L
I
G
I
D
S
V
Y
V----D-HN
I
R
E
D
I
W
S
K
L
A
-NEWNIG-
N
--
S
L
---
L
Y
N
---EI
G
F
E
E
F
Y
K
T
I
D
Q
L
LKG
Q
H
L
G
R
T
I
LKV
3
PsiBlast_PDB
94.84
37%
-107
- C1 -
3NX4
2
?
A:
[2-323]
--
Q
A
L
I
L
E
Q
Q
D
G
K
T
-
L
A
S
V
Q
H
L
E
E
S
Q
L
P
A
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
K
G
K
I
-------
I
R
H
F
P
M
I
P
G
I
D
F
A
G
T
V
H
A
S
E
--
D
--
P
R
F
H
A
G
Q
E
V
--------------
L
L
T
G
W
----------------------
G
------------------------------------------
V
G
E
N
H
W
--------
G
G
L
A
E
R
A
R
V
K
G
D
W
L
V
A
L
P
A
G
L
S
S
R
N
A
M
I
I
G
T
A
G
F
T
A
--
M
L
C
V
M
A
L
E
D
A
G
I
R
P
Q
-
D
-
G
-
E
V
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
-
Y
Q
-
V
A
A
V
S
G
R
E
S
T
----
H
G
Y
L
K
S
L
G
A
N
R
I
L
--
S
R
D
E
FA----
E
-------
S
R
--
P
L
E
K
Q
L
W
A
G
A
I
D
T
V
G
D
--
K
V
L
A
K
V
L
A
Q
M
N
Y
-
G
--------
G
C
V
A
A
C
G
L
A
G
G
F
A
-
L
P
T
T
V
M
-
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
----
P
-
P
A
R
R
A
E
A
W
A
R
L
V
-
K
--
D
L
P
-
E
--
S
F
Y
A
Q
A
A
T
---
E
I
T
L
A
D
A
P
K
F
A
D
A
I
I
N
N
Q
V
Q
G
R
T
L
V
K
I
21
PsiBlast_CBE
94.69
39%
-107
- C1 -
1O8C
2
ACUI_ECOLI
D:
[22-344]
-
L
Q
A
L
L
L
E
Q
Q
D
G
K
T
-
L
A
S
V
Q
T
L
D
E
S
R
L
P
E
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
K
G
K
I
-------
I
R
N
F
P
M
I
P
G
I
D
F
A
G
T
V
R
T
S
E
--
D
--
P
R
F
H
A
G
Q
E
V
--------------
L
L
T
G
W
----------------------
G
------------------------------------------
V
G
E
N
H
W
--------
G
G
L
A
E
Q
A
R
V
K
G
D
W
L
V
A
M
P
Q
G
L
D
A
R
K
A
M
I
I
G
T
A
G
F
T
A
--
M
L
C
V
M
A
L
E
D
A
G
V
R
P
Q
-
D
-
G
-
E
I
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
-
Y
Q
-
V
V
A
V
S
G
R
E
S
T
----
H
E
Y
L
K
S
L
G
A
S
R
V
L
--
P
R
D
E
FA----
E
-------
S
R
--
P
L
E
K
Q
V
W
A
G
A
I
D
T
V
G
D
--
K
V
L
A
K
V
L
A
Q
M
N
Y
-
G
--------
G
C
V
A
A
C
G
L
A
G
G
F
T
-
L
P
T
T
V
M
-
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
----
P
-
P
E
R
R
A
Q
A
W
Q
R
L
V
-
A
--
D
L
P
-
E
--
S
F
---
Y
T
Q
AAK
E
I
S
L
S
E
A
P
N
F
A
E
A
I
I
N
N
Q
I
Q
G
R
T
L
V
K
V
2
PsiBlast_PDB
93.76
39%
-105
- C1 -
1O8C
2
ACUI_ECOLI
A:
[22-344]
-
L
Q
A
L
L
L
E
Q
Q
D
G
K
T
-
L
A
S
V
Q
T
L
D
E
S
R
L
P
E
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
K
G
K
I
-------
I
R
N
F
P
M
I
P
G
I
D
F
A
G
T
V
R
T
S
E
--
D
--
P
R
F
H
A
G
Q
E
V
--------------
L
L
T
G
W
----------------------
G
------------------------------------------
V
G
E
N
H
W
--------
G
G
L
A
E
Q
A
R
V
K
G
D
W
L
V
A
M
P
Q
G
L
D
A
R
K
A
M
I
I
G
T
A
G
F
T
A
--
M
L
C
V
M
A
L
E
D
A
G
V
R
P
Q
-
D
-
G
-
E
I
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
-
Y
Q
-
V
V
A
V
S
G
R
E
S
T
----
H
E
Y
L
K
S
L
G
A
S
R
V
L
--
P
R
D
E
FA----
E
-------
S
R
--
P
L
E
K
Q
V
W
A
G
A
I
D
T
V
G
D
--
K
V
L
A
K
V
L
A
Q
M
N
Y
-
G
--------
G
C
V
A
A
C
G
L
A
G
G
F
T
-
L
P
T
T
V
M
-
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
----
P
-
P
E
R
R
A
Q
A
W
Q
R
L
V
-
A
--
D
L
P
-
E
--
S
F
---
Y
T
Q
A
A
K
E
I
S
L
S
E
A
P
N
F
A
E
A
I
I
N
N
Q
I
Q
G
R
T
L
V
K
V
23
PsiBlast_CBE
93.67
39%
-108
- C1 -
1O8C
2
ACUI_ECOLI
B:
[22-344]
-
L
Q
A
L
L
L
E
Q
Q
D
G
K
T
-
L
A
S
V
Q
T
L
D
E
S
R
L
P
E
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
K
G
K
I
-------
I
R
N
F
P
M
I
P
G
I
D
F
A
G
T
V
R
T
S
E
--
D
--
P
R
F
H
A
G
Q
E
V
--------------
L
L
T
G
W
----------------------
G
------------------------------------------
V
G
E
N
H
W
--------
G
G
L
A
E
Q
A
R
V
K
G
D
W
L
V
A
M
P
Q
G
L
D
A
R
K
A
M
I
I
G
T
A
G
F
T
A
--
M
L
C
V
M
A
L
E
D
A
G
V
R
P
Q
-
D
-
G
-
E
I
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
-
Y
Q
-
V
V
A
V
S
G
R
E
S
T
----
H
E
Y
L
K
S
L
G
A
S
R
V
L
--
P
R
D
E
FA----
E
-------
S
R
--
P
L
E
K
Q
V
W
A
G
A
I
D
T
V
G
D
--
K
V
L
A
K
V
L
A
Q
M
N
Y
-
G
--------
G
C
V
A
A
C
G
L
A
G
G
F
T
-
L
P
T
T
V
M
-
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
----
P
-
P
E
R
R
A
Q
A
W
Q
R
L
V
-
A
--
D
L
P
-
E
--
S
F
---
Y
T
Q
AAK
E
I
S
L
S
E
A
P
N
F
A
E
A
I
I
N
N
Q
I
Q
G
R
T
L
V
K
V
41
HHSearch
93.56
39%
-105
- C1 -
3NX4
2
?
A:
[1-323]
-
M
Q
A
L
I
L
E
Q
Q
D
G
K
T
-
L
A
S
V
Q
H
L
E
E
S
Q
L
P
A
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
K
G
K
I
-------
I
R
H
F
P
M
I
P
G
I
D
F
A
G
T
V
H
A
S
E
--
D
--
P
R
F
H
A
G
Q
E
V
--------------
L
L
T
G
W
----------------------
G
------------------------------------------
V
G
E
N
H
W
--------
G
G
L
A
E
R
A
R
V
K
G
D
W
L
V
A
L
P
A
G
L
S
S
R
N
A
M
I
I
G
T
A
G
F
T
A
--
M
L
C
V
M
A
L
E
D
A
G
--
I
R
-
P
Q
D
G
E
V
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
-
Y
Q
-
V
A
A
V
S
G
R
E
S
T
----
H
G
Y
L
K
S
L
G
A
N
R
I
L
--
S
R
D
E
FA----
E
-------
S
R
--
P
L
E
K
Q
L
W
A
G
A
I
D
T
V
G
D
--
K
V
L
A
K
V
L
A
Q
M
N
Y
-
G
--------
G
C
V
A
A
C
G
L
A
G
G
F
A
-
L
P
T
T
V
M
-
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
----
P
-
P
A
R
R
A
E
A
W
A
R
L
V
-
K
D
L
P
E
S
F
Y
--
A
Q
---
A
A
T
---
E
I
T
L
A
D
A
P
K
F
A
D
A
I
I
N
N
Q
V
Q
G
R
T
L
V
K
I
22
PsiBlast_CBE
93.38
39%
-105
- C1 -
1O8C
2
ACUI_ECOLI
C:
[23-344]
--
Q
A
L
L
L
E
Q
Q
D
G
K
T
-
L
A
S
V
Q
T
L
D
E
S
R
L
P
E
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
K
G
K
I
-------
I
R
N
F
P
M
I
P
G
I
D
F
A
G
T
V
R
T
S
E
--
D
--
P
R
F
H
A
G
Q
E
V
--------------
L
L
T
G
W
----------------------
G
------------------------------------------
V
G
E
N
H
W
--------
G
G
L
A
E
Q
A
R
V
K
G
D
W
L
V
A
M
P
Q
G
L
D
A
R
K
A
M
I
I
G
T
A
G
F
T
A
--
M
L
C
V
M
A
L
E
D
A
G
V
R
P
Q
-
D
-
G
-
E
I
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
-
Y
Q
-
V
V
A
V
S
G
R
E
S
T
----
H
E
Y
L
K
S
L
G
A
S
R
V
L
--
P
R
D
E
FA----
E
-------
S
R
--
P
L
E
K
Q
V
W
A
G
A
I
D
T
V
G
D
--
K
V
L
A
K
V
L
A
Q
M
N
Y
-
G
--------
G
C
V
A
A
C
G
L
A
G
G
F
T
-
L
P
T
T
V
M
-
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
----
P
-
P
E
R
R
A
Q
A
W
Q
R
L
V
-
A
--
D
L
P
-
E
--
S
F
---
Y
T
Q
AAK
E
I
S
L
S
E
A
P
N
F
A
E
A
I
I
N
N
Q
I
Q
G
R
T
L
V
K
V
1
PsiBlast_PDB
93.19
39%
-108
- C1 -
1O89
-
ACUI_ECOLI
A:
[1-323]
-
L
Q
A
L
L
L
E
Q
Q
---
T
-
L
A
S
V
Q
T
L
D
E
S
R
L
P
E
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
K
G
K
I
-------
I
R
N
F
P
M
I
P
G
I
D
F
A
G
T
V
R
T
S
E
--
D
--
P
R
F
H
A
G
Q
E
V
--------------
L
L
T
G
W
----------------------
G
------------------------------------------
V
G
E
N
H
W
--------
G
G
L
A
E
Q
A
R
V
K
G
D
W
L
V
A
M
P
Q
G
L
D
A
R
K
A
M
I
I
G
T
A
G
F
T
A
--
M
L
C
V
M
A
L
E
D
A
G
V
R
P
Q
-
D
-
G
-
E
I
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
-
Y
Q
-
V
V
A
V
S
G
R
E
S
T
----
H
E
Y
L
K
S
L
G
A
S
R
V
L
--
P
R
D
E
FA----
E
-------
S
R
--
P
L
E
K
Q
V
W
A
G
A
I
D
T
V
G
D
--
K
V
L
A
K
V
L
A
Q
M
N
Y
-
G
--------
G
C
V
A
A
C
G
L
A
G
G
F
T
-
L
P
T
T
V
M
-
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
----
P
-
P
E
R
R
A
Q
A
W
Q
R
L
V
-
A
--
D
L
P
-
E
--
S
F
---
Y
T
Q
A
A
K
E
I
S
L
S
E
A
P
N
F
A
E
A
I
I
N
N
Q
I
Q
G
R
T
L
V
K
V
31
Fugue
92.41
40%
-105
- C1 -
1O89
-
ACUI_ECOLI
A:
[1-323]
-
L
Q
A
L
L
L
E
Q
Q
T
----
L
A
S
V
Q
T
L
D
E
S
R
L
P
E
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
K
G
K
I
-------
I
R
N
F
P
M
I
P
G
I
D
F
A
G
T
V
R
T
S
E
--
D
--
P
R
F
H
A
G
Q
E
V
--------------
L
L
T
G
W
----------------------
G
------------------------------------------
V
G
E
N
H
W
--------
G
G
L
A
E
Q
A
R
V
K
G
D
W
L
V
A
M
P
Q
G
L
D
A
R
K
A
M
I
I
G
T
A
G
F
T
A
--
M
L
C
V
M
A
L
E
D
A
G
V
R
-
P
-
Q
-
D
G
E
I
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
-
Y
Q
-
V
V
A
V
S
G
R
E
S
T
----
H
E
Y
L
K
S
L
G
A
S
R
V
L
--
P
R
D
E
FA----
E
-------
S
R
--
P
L
E
K
Q
V
W
A
G
A
I
D
T
V
G
D
--
K
V
L
A
K
V
L
A
Q
M
N
Y
-
G
--------
G
C
V
A
A
C
G
L
A
G
G
F
T
-
L
P
T
T
V
M
-
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
----
P
-
P
E
R
R
A
Q
A
W
Q
R
L
V
-
A
D
L
P
E
S
-
F
Y
-
T
Q
---
A
A
K
---
E
I
S
L
S
E
A
P
N
F
A
E
A
I
I
N
N
Q
I
Q
G
R
T
L
V
K
V
6
PsiBlast_PDB
92.18
41%
-99
- C1 -
1Y9E
2
YHFP_BACSU
A:
[4-330]
L
F
Q
A
L
Q
A
E
K
N
A
D
D
V
-
S
V
H
V
K
T
I
S
T
E
D
L
P
K
D
G
V
L
I
K
V
A
Y
S
G
I
N
Y
K
D
G
L
A
G
K
A
G
G
N
I
-------
V
R
E
Y
P
L
I
L
G
I
D
A
A
G
T
V
V
S
S
N
--
D
--
P
R
F
A
E
G
D
E
V
--------------
I
A
T
S
Y
----------------------
E
------------------------------------------
L
G
V
S
R
D
--------
G
G
L
S
E
Y
A
S
V
P
G
D
W
L
V
P
L
P
Q
N
L
S
L
K
E
A
M
V
Y
G
T
A
G
F
T
A
--
A
L
S
V
H
R
L
E
Q
N
G
L
S
-
P
-
E
-
K
G
S
V
L
V
T
G
A
T
G
G
V
G
G
I
A
V
S
M
L
N
K
R
G
-
Y
D
V
V
A
S
T
G
N
R
E
A
A
-----
D
Y
L
K
Q
L
G
A
S
E
V
I
--
S
R
E
D
VYDG--
T
-------
L
K
--
A
L
S
K
Q
Q
W
Q
G
A
V
D
P
V
G
G
--
K
Q
L
A
S
L
L
S
K
I
Q
Y
-
G
--------
G
S
V
A
V
S
G
L
T
G
G
G
E
-
V
P
A
T
V
Y
-
P
F
I
L
R
G
V
S
L
L
G
I
D
S
V
Y
C
----
P
-
M
D
V
R
A
A
V
W
E
R
M
S
-
S
D
L
K
P
D
-
Q
LL
T
I
---
V
D
R
---
E
V
S
L
E
E
T
P
G
A
L
K
D
I
L
Q
N
R
I
Q
G
R
V
I
V
K
L
4
PsiBlast_PDB
90.16
37%
-100
- C1 -
4JXK
2
?
A:
[26-349]
-
F
T
A
W
I
A
R
E
N
E
G
A
I
-
G
L
S
Q
E
T
V
G
E
S
F
L
P
Q
G
E
V
T
I
Q
V
E
Y
S
S
V
N
F
K
D
A
L
A
L
T
P
K
G
G
V
-------
V
R
E
Y
P
I
V
P
G
I
D
V
A
G
T
V
V
E
S
Q
--
S
--
P
E
F
S
V
G
D
T
V
--------------
V
A
H
G
Y
----------------------
D
------------------------------------------
I
G
T
A
R
H
--------
G
G
Y
A
Q
F
A
R
V
P
A
D
W
V
V
K
L
-
D
G
M
S
T
R
T
A
A
A
I
G
T
A
G
F
T
A
--
A
M
S
V
E
A
L
Q
S
R
G
V
E
P
G
-
N
-
G
P
-
V
L
V
T
G
A
S
G
G
V
G
T
V
A
V
D
L
L
S
A
A
G
-
F
E
V
V
A
S
S
G
K
P
E
K
A
-----
E
L
L
T
Q
L
G
A
S
K
V
I
G
R
L
P
E
P
------
D
-------
T
K
PR
P
L
G
K
A
Q
W
A
A
A
V
D
C
V
G
G
--
A
T
L
A
H
V
L
S
T
I
E
Y
-
G
--------
G
A
V
A
A
S
G
L
T
G
G
P
K
-
L
E
T
T
V
L
-
P
F
I
L
R
G
V
S
L
L
G
I
D
S
V
Q
Y
----
P
-
I
D
Q
R
R
R
L
W
G
R
L
A
-
S
D
L
A
P
S
-
R
L-
E
S
---
I
T
H
---
D
V
P
I
A
D
V
V
S
V
I
D
Q
V
R
A
G
T
Y
S
G
R
A
V
V
A
V
24
PsiBlast_CBE
87.30
37%
-97
- C1 -
4JXK
2
?
B:
[26-349]
-
F
T
A
W
I
A
R
E
N
E
G
A
I
-
G
L
S
Q
E
T
V
G
E
S
F
L
P
Q
G
E
V
T
I
Q
V
E
Y
S
S
V
N
F
K
D
A
L
A
L
T
P
K
G
G
V
-------
V
R
E
Y
P
I
V
P
G
I
D
V
A
G
T
V
V
E
S
Q
--
S
--
P
E
F
S
V
G
D
T
V
--------------
V
A
H
G
Y
----------------------
D
------------------------------------------
I
G
T
A
R
H
--------
G
G
Y
A
Q
F
A
R
V
P
A
D
W
V
V
K
L
-
D
G
M
S
T
R
T
A
A
A
I
G
T
A
G
F
T
A
--
A
M
S
V
E
A
L
Q
S
R
G
V
E
P
G
-
N
-
G
P
-
V
L
V
T
G
A
S
G
G
V
G
T
V
A
V
D
L
L
S
A
A
G
-
F
E
V
V
A
S
S
G
K
P
E
K
A
-----
E
L
L
T
Q
L
G
A
S
K
V
I
GR
L
P
E
P
------
D
-------
T
K
PR
P
L
G
K
A
Q
W
A
A
A
V
D
C
V
G
G
--
A
T
L
A
H
V
L
S
T
I
E
Y
-
G
--------
G
A
V
A
A
S
G
L
T
G
G
P
K
-
L
E
T
T
V
L
-
P
F
I
L
R
G
V
S
L
L
G
I
D
S
V
Q
Y
----
P
-
I
D
Q
R
R
R
L
W
G
R
L
A
-
S
D
L
A
P
S
-
R
L-
E
S
---
I
T
H
---
D
V
P
I
A
D
V
V
S
V
I
D
Q
V
R
A
G
T
Y
S
G
R
A
V
V
A
V
49
HHSearch
67.50
20%
-87
- C1 -
2EIH
1
?
A:
[1-342]
-
M
R
A
V
V
M
R
A
R
G
G
P
E
-
V
L
E
V
A
D
L
P
V
P
E
P
G
P
K
E
V
R
V
R
L
K
A
A
A
L
N
H
L
D
V
W
V
R
K
G
V
A
S
P
-------
K
L
P
L
P
H
V
L
G
A
D
G
S
G
V
V
D
A
V
G
PG
V
--
E
G
F
A
P
G
D
E
V
--------------
V
I
N
P
G
----------------------
L
SCGRC
E
R
C
L
A
GEDNLCPRYQI---------------------
L
G
E
H
R
H
--------
G
T
Y
A
E
Y
V
V
L
P
E
A
N
L
A
P
K
P
K
N
L
S
F
E
E
A
A
A
I
P
L
T
F
L
T
A
--
W
Q
M
V
V
D
K
L
G
----
V
R
-
P
-
G
D
D
V
L
V
M
A
A
G
S
G
V
S
V
A
A
I
Q
I
A
K
L
F
G
-
A
R
-
V
I
A
T
A
G
S
E
D
K
----
L
R
R
A
K
A
L
G
A
D
E
T
V
--
N
Y
T
H
PD
W
P
K
E
V
-------
R
R
--
L
T
G
G
K
G
A
D
K
V
V
D
H
T
G
A
--
L
Y
F
E
G
V
I
K
A
T
A
N
-
G
--------
G
R
I
A
I
A
G
A
S
S
G
Y
E
-
G
T
L
P
F
A
-
H
V
F
Y
R
Q
L
S
I
L
G
S
T
M
--
A
----
S
-
K
S
R
L
F
P
I
L
R
F
V
E
E
G
K
L
K
P
------
V
---
V
G
Q
---
V
L
P
L
E
A
A
A
E
G
H
R
L
L
E
E
R
R
V
F
G
K
V
V
L
Q
V
51
HHSearch
67.26
22%
-90
- C1 -
3S2E
7
?
A:
[2-338]
M
M
K
A
A
V
V
R
A
F
G
A
P
---
L
T
I
D
E
V
P
V
P
Q
P
G
P
G
Q
V
Q
V
K
I
E
A
S
G
V
C
H
T
D
L
H
A
A
D
G
D
W
P
V
-------
K
P
T
L
P
F
I
P
G
H
E
G
V
G
Y
V
S
A
V
G
SG
V
--
S
R
V
K
E
G
D
R
V
--------------
G
V
P
W
L
YSACGYC
E
H
C
L
Q
GWETLCEK
Q
Q
N
------------------------------------------
T
G
Y
S
V
N
--------
G
G
Y
G
E
Y
V
V
A
D
P
N
Y
V
G
L
L
P
D
K
V
G
F
V
E
I
A
P
I
L
C
A
G
V
T
V
--
Y
K
G
L
K
V
T
-
D
----
T
R
-
P
-
G
Q
W
V
V
I
S
G
I
-
G
G
L
G
H
V
A
V
Q
Y
A
R
A
M
G
-
L
R
-
V
A
A
V
D
I
D
D
A
K
----
L
N
L
A
R
R
L
G
A
E
V
A
V
--
N
A
R
D
------
T
D
P
A
A
W
--
L
Q
--
K
E
I
G
G
A
H
G
V
L
V
T
A
V
S
P
--
K
A
F
S
Q
A
I
G
M
V
R
R
-
G
--------
G
T
I
A
L
N
G
L
P
P
G
D
--
F
G
T
P
I
F
-
D
V
V
L
K
G
I
T
I
R
G
S
I
V
--
G
----
T
-
R
S
D
L
Q
E
S
L
D
F
A
A
H
G
D
V
-------
K
A
---
T
V
S
---
T
A
K
L
D
D
V
N
D
V
F
G
R
L
R
E
G
K
V
E
G
R
V
V
L
D
F
56
HHSearch
65.69
21%
-88
- C1 -
2FZW
6
ADHX_HUMAN
A:
[6-371]
K
C
K
A
A
V
A
W
E
A
G
K
P
---
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
T
L
S
G
A
D
P
--------
E
G
C
F
P
V
I
L
G
H
L
G
A
G
I
V
E
S
V
G
EG
V
--
T
K
L
K
A
G
D
T
V
--------------
I
P
L
Y
I
----------------------
P
QCGECKFCLNPKTNLCQKI
R
V
T
Q
G
K
GLMPDGTSRFTCKG
K
T
I
L
H
Y
M
G
T
--------
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
--
Y
G
A
A
V
N
T
A
K
----
L
E
-
P
-
G
S
V
C
A
V
F
G
L
-
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
-
A
S
R
I
I
G
V
D
I
N
K
D
K
----
F
A
R
A
K
E
F
G
A
T
E
C
I
--
N
P
Q
D
------
F
SKP
I
Q
E
V
L
I
--
E
M
T
D
G
G
V
D
Y
S
F
E
C
I
G
N
V
-
K
V
M
R
A
A
L
E
A
C
H
K
G
W
--------
G
V
S
V
V
V
G
V
A
A
S
G
E
--
E
I
A
T
R
P
F
Q
L
V
T
G
R
T
W
K
G
T
A
F
G
G
W
----
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
----
E
F
---
V
T
H
---
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
-
R
T
V
V
--
43
HHSearch
64.57
19%
-80
- C1 -
1ZSY
4
MECR_HUMAN
A:
[26-357]
R
V
R
A
L
V
Y
G
H
H
G
D
P
A
K
V
V
E
L
K
N
L
E
L
A
A
V
R
G
S
D
V
R
V
K
M
L
A
A
P
I
N
P
S
D
I
N
M
I
Q
G
N
Y
G
L
-------
L
P
E
L
P
A
V
G
G
N
E
G
V
A
Q
V
V
A
V
G
SN
V
--
T
G
L
K
P
G
D
W
V
--------------
I
P
A
N
A
---------------------------------------------------------------------
G
L
--------
G
T
W
R
T
E
A
V
F
S
E
E
A
L
I
Q
V
P
S
D
I
P
L
Q
S
A
A
T
L
G
V
N
P
C
T
A
--
Y
R
M
L
M
D
F
E
Q
----
L
Q
-
P
-
G
D
S
V
I
Q
N
A
S
N
S
G
V
G
Q
A
V
I
Q
I
A
A
A
L
G
-
L
R
-
T
I
N
V
V
R
D
R
P
D
I
Q
K
L
S
D
R
L
K
S
L
G
A
E
H
V
I
--
T
E
E
E
------
L
R
R
P
E
M
K
-
N
F
--
F
K
D
M
P
Q
P
R
L
A
L
N
C
V
G
G
--
K
S
S
T
E
L
L
R
Q
L
A
R
-
G
--------
G
T
M
V
T
Y
G
G
M
A
K
Q
P
-
V
V
A
S
V
S
-
L
L
I
F
K
D
L
K
L
R
G
F
W
L
S
Q
W
K
K
D
H
S
-
P
D
Q
F
K
E
L
I
L
T
L
C
-
D
L
I
R
R
G
Q
L
--
T
A
P
--
A
C
S
---
Q
V
P
L
Q
D
Y
Q
S
A
L
E
A
S
M
K
P
F
I
S
S
K
Q
I
L
T
M
45
HHSearch
63.74
43%
-47
- C1 -
1TT7
-
YHFP_BACSU
A:
[4-330]
L
F
Q
A
L
Q
A
E
K
N
A
D
D
V
-
S
V
H
V
K
T
I
S
T
E
D
L
P
K
D
G
V
L
I
K
V
A
Y
S
G
I
N
Y
K
D
G
L
A
G
K
A
G
G
N
I
-------
V
R
E
Y
P
L
I
L
G
I
D
A
A
G
T
V
V
S
S
N
--
D
--
P
R
F
A
E
G
D
E
V
--------------
I
A
T
S
Y
----------------------
E
------------------------------------------
L
G
V
S
R
D
--------
G
G
L
S
E
Y
A
S
V
P
G
D
W
L
V
P
L
P
Q
N
L
S
L
K
E
A
M
V
Y
G
T
A
G
F
T
A
--
A
L
S
V
H
R
L
E
Q
N
G
--
L
S
P
E
-
K
G
S
V
L
V
T
G
A
T
G
G
V
G
G
I
A
V
S
M
L
N
K
R
G
-
Y
D
-
V
V
A
S
T
G
N
R
E
A
----
A
D
Y
L
K
Q
L
G
A
S
E
V
I
--
S
R
E
D
------
V
YDGT---
L
K
--
A
L
S
K
Q
Q
W
Q
G
A
V
D
P
V
G
G
--
K
Q
L
A
S
L
L
S
K
I
Q
Y
-
G
--------
G
S
V
A
V
S
G
L
T
G
G
G
E
-
V
P
A
T
V
Y
-
P
F
I
L
R
G
V
S
L
L
G
I
D
S
V
Y
C
----
P
-
M
D
V
R
A
A
V
W
E
R
M
S
-
S
D
L
K
P
D
Q
L
--
L
T
I--
V
D
R
---
E
V
S
L
E
E
T
P
G
A
L
K
D
I
L
Q
N
R
I
Q
G
R
V
I
V
K
L
60
HHSearch
61.76
21%
-86
- C1 -
1F8F
6
?
A:
[6-370]
D
I
I
A
A
V
T
P
C
K
G
A
---
D
F
E
L
Q
A
L
K
I
R
Q
P
Q
G
D
E
V
L
V
K
V
V
A
T
G
M
C
H
T
D
L
I
V
R
D
Q
K
Y
P
---------
V
P
L
P
A
V
L
G
H
E
G
S
G
I
I
E
A
I
G
PN
V
--
T
E
L
Q
V
G
D
H
V
--------------
V
L
S
Y
G
----------------------
Y
CGKC
T
Q
C
N
T
GNPAYCSEFFGRNFSGADSEGNHALCVN-----
D
H
F
F
A
Q
--------
S
S
F
A
T
Y
A
L
S
R
E
N
N
T
V
K
V
T
K
D
V
P
I
E
L
L
G
P
L
G
C
G
I
Q
T
G
--
A
G
A
C
I
N
A
L
K
----
V
T
-
P
-
A
S
S
F
V
T
W
G
A
-
G
A
V
G
L
S
A
L
L
A
A
K
V
C
G
-
A
S
I
I
I
A
V
D
I
V
E
S
R
----
L
E
L
A
K
Q
L
G
A
T
H
V
I
--
N
S
K
T
------
Q
D
P
V
A
A
--
I
K
--
E
I
T
D
G
G
V
N
F
A
L
E
S
T
G
S
P
-
E
I
L
K
Q
G
V
D
A
L
G
I
-
L
--------
G
K
I
A
V
V
G
A
P
Q
L
G
T
T
A
Q
F
D
V
N
-
D
L
L
L
G
G
K
T
I
L
G
V
V
E
G
S
G
S---
P
-
K
K
F
I
P
E
L
V
R
L
Y
Q
Q
G
K
F
P
F
D
-----
Q
---
L
V
K
---
F
Y
A
F
D
E
I
N
Q
A
A
I
D
S
R
K
G
I
-
T
L
K
P
I
I
K
I
54
HHSearch
61.49
21%
-96
- C1 -
3TQH
3
?
A:
[6-320]
E
M
K
A
I
Q
F
D
Q
F
G
P
P
K
-
V
L
K
L
V
D
T
P
T
P
E
Y
R
K
N
Q
M
L
I
K
V
H
A
A
S
L
N
P
I
D
Y
K
T
R
N
G
S
G
F
V
A
K
K
L
---
K
N
N
L
P
S
G
L
G
Y
D
F
S
G
E
V
I
E
L
G
SD
V
--
N
N
V
N
I
G
D
K
V
--------------
M
G
I
A
G
----------------------
F
--------------------------------------------
P
D
H
P
--------
C
C
Y
A
E
Y
V
C
A
S
P
D
T
I
I
Q
K
L
E
K
L
S
F
L
Q
A
A
S
L
P
T
A
G
L
T
A
--
L
Q
A
L
N
Q
A
-
E
----
V
K
-
Q
-
G
D
V
V
L
I
H
A
G
A
G
G
V
G
H
L
A
I
Q
L
A
K
Q
K
G
-
T
T
-
V
I
T
T
A
S
K
-
R
N
----
H
A
F
L
K
A
L
G
A
E
Q
C
I
--
N
Y
H
E
E-----
D
-------
F
L
--
L
A
I
S
T
P
V
D
A
V
I
D
L
V
G
G
--
D
V
G
I
Q
S
I
D
C
L
K
E
-
T
--------
G
C
I
V
S
V
P
T
I
T
A
G
R
-
V
-
I
E
V
A
---
K
Q
K
H
R
R
A
F
G
L
L
K
-
Q
F
----
N
-
I
E
E
L
H
Y
L
G
K
L
V
S
E
D
K
L
R
I
------
E
---
I
S
R
---
I
F
Q
L
S
E
A
V
T
A
H
E
L
L
E
T
G
H
V
R
G
K
L
V
F
K
V
47
HHSearch
61.42
21%
-80
- C1 -
1JVB
2
ADH_SULSO
A:
[1-347]
-
M
R
A
V
R
L
V
E
I
G
K
P
---
L
S
L
Q
E
I
G
V
P
K
P
K
G
P
Q
V
L
I
K
V
E
A
A
G
V
C
H
S
D
V
H
M
R
Q
G
R
F
G
N
LRIVEDL
G
V
K
L
P
V
T
L
G
H
E
I
A
G
K
I
E
E
V
G
DE
V
--
V
G
Y
S
K
G
D
L
V
--------------
A
V
N
P
W
----------------------
Q
GEGNC
Y
Y
C
R
I
GEEHLCDSPRW---------------------
L
G
I
N
F
D
--------
G
A
Y
A
E
Y
V
I
V
P
H
Y
K
Y
M
Y
K
L
R
R
L
N
A
V
E
A
A
P
L
T
C
S
G
I
T
T
--
Y
R
A
V
R
K
-
A
S
----
L
D
-
P
-
T
K
T
L
L
V
V
G
A
G
G
G
L
G
T
M
A
V
Q
I
A
K
A
V
S
G
A
T
-
I
I
G
V
D
V
R
E
E
A
----
V
E
A
A
K
R
A
G
A
D
Y
V
I
--
N
A
S
M
QD
P
L
A
E
I
-------
R
R
--
I
T
E
S
K
G
V
D
A
V
I
D
L
N
N
S
E
-
K
T
L
S
V
Y
P
K
A
L
A
K
-
Q
--------
G
K
Y
V
M
V
G
L
F
G
A
D
L
--
H
Y
H
A
P
-
L
I
T
L
S
E
I
Q
F
V
G
S
L
V
--
G
----
N
-
Q
S
D
F
L
G
I
M
R
L
A
E
A
G
K
V
K
P
------
M
---
I
T
K
---
T
M
K
L
E
E
A
N
E
A
I
D
N
L
E
N
F
K
A
I
G
R
Q
V
L
I
P
9
PsiBlast_PDB
61.02
24%
-87
- C1 -
3PII
5
ADH3_GEOSE
A:
[14-334]
-----------------
K
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
G
D
W
P
V
-------
K
P
K
L
P
L
I
P
G
H
E
G
V
G
I
V
E
E
V
G
--
P
GV
T
H
L
K
V
G
D
R
V
G
I
P
WLYSACGHC
D
Y
C
L
S
G
Q
----------------------
E
------------------------------------------
T
L
C
E
H
Q
K
N
A
GYSVD
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
I
P
D
N
L
S
F
E
E
A
A
P
I
F
C
A
G
V
T
T
Y
K
A
L
K
V
-------
T
G
A
K
-
P
-
G
E
W
V
A
I
Y
G
-
I
G
G
F
G
H
V
A
V
Q
Y
A
K
A
M
G
-
L
-
N
V
V
A
V
D
I
G
D
E
K
----
L
E
L
A
K
E
L
G
A
D
L
V
V
---------------------
N
--
P
L
K
E
D
A
A
K
F
M
K
E
K
V
G
G
VH
A
A
V
V
T
A
V
S
K
P
A
F
-
Q
S
A
Y
N
S
IRR
G
G
A
C
V
L
V
G
L
P
P
E
E
-
M
P
I
P
I
F
-
D
T
V
L
N
G
I
K
I
I
G
-
S
I
V
G
T
----
R
-
K
D
L
Q
E
A
L
--
Q
F
A
-
A
E
G
K
V
K
-
T
--
I
I
---
E
V
Q
---
P
L
--
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
--