@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0003: (2015-12-11 )
MKTSNTKTPKPVLIAGPCVIESLENLRSIAIKLQPLANNERLDFYFKASFDKANRTSLESYRGPGLEKGLEMLQTIKDEFGYKILTDVHESYQASVAAKVADILQIPAFLCRQTDLIVEVSQTNAIVNIKKGQFMNPKDMQYSVLKALKTRDSSIQSPTYETALKNGVWLCERGSSFGYGNLVVDMRSLKIMREFAPVIFDATHSVQMPGGANGKSSGDSSFPPILPRAAAAVGIDGLFAETHIDPKNALSDGANMLKPDELEHLVTDMLKIQNLF
Atome Classification :
(58 SA)
.........10........20........30.......--.-40.........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160...--....170.......180.......190...---.-...200.......210.......220.......230-.......240.--......250.......260.......270....-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKTSNTKTPK
P
V
L
I
A
G
P
C
V
I
E
S
L
E
N
L
R
S
I
A
I
K
L
Q
PLAN--N-E-
R
L
D
F
Y
F
KASFDKANRT
S
L
E
S
YRGP
G
L
E
K
G
L
E
M
L
Q
T
I
K
D
E
FGY
K
I
L
T
D
V
H
E
S
Y
Q
A
S
V
A
A
K
V
A
D
I
L
Q
I
P
A
F
L
CRQT
D
L
I
V
E
VSQT
N
A
I
V
N
IKKGQFM
N
P
K
D
M
Q
Y
S
V
L
K
A
L
K
TRDSSIQSP
T
Y
E
T
A
LK--N
G
V
W
L
C
ERGSSFGYG
N
L
V
V
D
M
R
S
L
K
I
M
R
E
F
---
A
-
P
V
I
FDATHSVQMPGGANGKSSGDSSFPPIL
P
R
A
A
A
A
-VGID
G
L
F
AETH--IDPKNALSDGANML
K
P
D
E
L
E
H
L
V
T
D
M
L
K
I
QNLF-------
21
PsiBlast_CBE
95.82
49%
-95
- C5 -
3E12
5
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
------
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
13
PsiBlast_PDB
95.42
49%
-92
- C5 -
1PCW
3
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
------
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
6
PsiBlast_PDB
95.35
49%
-96
- C5 -
1FXP
4
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
----------
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
19
PsiBlast_PDB
95.21
48%
-97
- C5 -
1T96
3
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
G
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
22
PsiBlast_CBE
95.16
49%
-96
- C5 -
3E0I
4
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
11
PsiBlast_PDB
95.12
49%
-93
- C5 -
1PE1
4
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
------
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
5
PsiBlast_PDB
95.04
49%
-96
- C5 -
1FX6
1
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
------------
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
9
PsiBlast_PDB
95.00
49%
-93
- C5 -
1JCX
3
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
--------
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
2
PsiBlast_PDB
94.94
49%
-95
- C5 -
1FWS
4
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
20
PsiBlast_PDB
94.93
48%
-96
- C5 -
1T99
2
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
G
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
44
PsiBlast_CBE
94.87
48%
-96
- C5 -
1T8X
3
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
G
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
------
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
1
PsiBlast_PDB
94.84
49%
-94
- C5 -
1FWN
3
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
4
PsiBlast_PDB
94.78
49%
-85
- C5 -
1FWW
4
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
D
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
56
PsiBlast_CBE
94.68
48%
-94
- C5 -
2NWR
3
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
N
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
------
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
28
PsiBlast_CBE
94.61
49%
-94
- C5 -
1JCY
4
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
3
PsiBlast_PDB
94.61
49%
-87
- C5 -
1FWT
4
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
D
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
32
PsiBlast_CBE
94.58
49%
-94
- C5 -
1FXP
3
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
------------
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
33
PsiBlast_CBE
94.57
49%
-99
- C5 -
1FX6
1
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
-------------
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
23
PsiBlast_CBE
94.57
49%
-94
- C5 -
2A2I
4
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
39
PsiBlast_CBE
94.54
48%
-90
- C5 -
1ZJI
3
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
G
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
------
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
43
PsiBlast_CBE
94.50
48%
-95
- C5 -
1T96
3
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
G
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
12
PsiBlast_PDB
94.50
49%
-94
- C5 -
1PCK
4
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
-----
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
26
PsiBlast_CBE
94.44
49%
-96
- C5 -
1PCW
3
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
--------
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
8
PsiBlast_PDB
94.43
49%
-92
- C5 -
1FY6
4
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
-----
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
48
PsiBlast_CBE
94.35
48%
-92
- C5 -
1LRO
4
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
G
S
V
Q
L
P
G
G
L
G
----
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
29
PsiBlast_CBE
94.28
49%
-93
- C5 -
1JCX
3
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
--------
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
14
PsiBlast_PDB
94.28
49%
-85
- C5 -
2A21
4
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
D
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
41
PsiBlast_CBE
94.26
48%
-95
- C5 -
1ZHA
3
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
G
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
37
PsiBlast_CBE
94.24
49%
-95
- C5 -
1FWN
3
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
10
PsiBlast_PDB
94.22
49%
-86
- C5 -
1JCY
4
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
D
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
18
PsiBlast_PDB
94.20
48%
-92
- C5 -
1T8X
3
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
G
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
------
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
35
PsiBlast_CBE
94.17
49%
-95
- C5 -
1FWT
4
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
--------
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
27
PsiBlast_CBE
94.15
49%
-94
- C5 -
1PCK
4
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
40
PsiBlast_CBE
94.14
48%
-94
- C5 -
1ZHA
3
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
G
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
38
PsiBlast_CBE
94.12
48%
-94
- C5 -
1ZJI
3
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
G
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
------
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
7
PsiBlast_PDB
94.08
49%
-86
- C5 -
1FXQ
3
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
D
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
24
PsiBlast_CBE
93.99
49%
-94
- C5 -
2A21
4
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
47
PsiBlast_CBE
93.97
48%
-95
- C5 -
1LRO
4
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
G
S
V
Q
L
P
G
-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
36
PsiBlast_CBE
93.84
49%
-95
- C5 -
1FWS
4
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
55
PsiBlast_CBE
93.77
48%
-94
- C5 -
2NWR
3
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
N
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
15
PsiBlast_PDB
93.75
49%
-85
- C5 -
2A2I
4
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
D
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
104
Fugue
93.57
51%
-84
- C5 -
1FXQ
3
KDSA_AQUAE
A:
[2-264]
--------
E
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
---
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
---------------GA
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
----
A
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
D
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
-
G
C
D
G
V
F
M
E
T
H
PE--
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
SKYYETI
25
PsiBlast_CBE
93.56
49%
-94
- C5 -
1PE1
4
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
34
PsiBlast_CBE
93.54
49%
-94
- C5 -
1FWW
4
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
52
PsiBlast_CBE
93.40
48%
-86
- C5 -
2NX1
3
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
N
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
D
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
81
PsiBlast_CBE
93.36
48%
-94
- C5 -
2NXG
2
KDSA_AQUAE
B:
[2-255]
---------
K
F
L
V
I
A
G
P
N
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
P
T
A
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
54
PsiBlast_CBE
93.30
48%
-83
- C5 -
2NWS
3
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
N
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
D
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
16
PsiBlast_PDB
93.27
49%
-85
- C5 -
3E0I
4
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
D
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
96
PsiBlast_CBE
92.97
48%
-85
- C5 -
2EF9
3
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
M
N
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
D
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
P
T
A
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
82
PsiBlast_CBE
92.92
48%
-82
- C5 -
2NXG
3
KDSA_AQUAE
A:
[2-255]
---------
K
F
L
V
I
A
G
P
N
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
D
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
P
T
A
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
31
PsiBlast_CBE
92.85
49%
-85
- C5 -
1FXQ
3
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
D
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
51
PsiBlast_CBE
92.42
48%
-86
- C5 -
2NX1
3
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
N
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
D
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
46
PsiBlast_CBE
92.34
48%
-84
- C5 -
1LRQ
4
KDSA_AQUAE
A:
[3-256]
---------
K
F
L
V
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
G
S
V
Q
L
P
G
G
L
G
D
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
112
HHSearch
92.29
51%
-86
* C5 *
2NWR
3
KDSA_AQUAE
A:
[2-256]
--------
E
K
F
L
V
I
A
G
P
N
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
-
F
K
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
-------------
A
--
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
------
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
95
PsiBlast_CBE
92.06
48%
-83
- C5 -
2EF9
3
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
M
N
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
D
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
P
T
A
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
53
PsiBlast_CBE
92.04
48%
-83
- C5 -
2NWS
3
KDSA_AQUAE
B:
[3-256]
---------
K
F
L
V
I
A
G
P
N
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
--
K
F
K
-
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
-
N
V
V
E
K
L
K
F
G
G
A
--------------
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
---
A
-
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
D
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
-
V
G
C
D
G
V
F
M
E
T
H
--
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
-------
101
PsiBlast_CBE
85.13
43%
-76
- C5 -
3UND
5
?
D:
[22-275]
-----------
V
L
F
G
G
I
N
V
L
E
S
L
D
F
T
L
D
V
C
G
E
Y
V
A
V
T
R
--
K
-
L
-
G
I
P
F
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
V
G
L
D
E
G
L
K
I
F
A
E
V
K
A
R
F
G
V
P
V
I
T
D
V
H
E
A
E
Q
A
A
P
V
A
E
I
A
D
V
L
Q
V
P
A
F
L
A
R
Q
T
D
L
V
V
A
I
A
K
A
G
K
P
V
N
V
K
K
P
Q
F
M
S
P
T
Q
L
K
H
V
V
S
K
C
G
E
V
G
N
D
R
---------------
V
M
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
R
Q
M
A
E
T
TGG
C
-
P
V
I
F
D
V
T
H
S
L
Q
C
R
D
P
L
G
D
A
S
G
G
R
R
R
Q
V
L
D
L
A
R
A
G
I
A
-
V
G
I
A
G
L
F
L
E
A
H
--
P
D
P
D
R
A
R
C
D
G
P
S
A
L
P
L
H
Q
L
E
G
L
L
S
Q
M
K
A
I
D
D
L
V
-------
102
PsiBlast_CBE
85.07
43%
-76
- C5 -
3UND
6
?
C:
[22-275]
-----------
V
L
F
G
G
I
N
V
L
E
S
L
D
F
T
L
D
V
C
G
E
Y
V
A
V
T
R
--
K
-
L
-
G
I
P
F
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
V
G
L
D
E
G
L
K
I
F
A
E
V
K
A
R
F
G
V
P
V
I
T
D
V
H
E
A
E
Q
A
A
P
V
A
E
I
A
D
V
L
Q
V
P
A
F
L
A
R
Q
T
D
L
V
V
A
I
A
K
A
G
K
P
V
N
V
K
K
P
Q
F
M
S
P
T
Q
L
K
H
V
V
S
K
C
G
E
V
G
N
D
R
---------------
V
M
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
R
Q
M
A
E
T
T
GG
C
-
P
V
I
F
D
V
T
H
S
L
Q
C
R
D
P
L
G
D
A
S
G
G
R
R
R
Q
V
L
D
L
A
R
A
G
I
A
-
V
G
I
A
G
L
F
L
E
A
H
--
P
D
P
D
R
A
R
C
D
G
P
S
A
L
P
L
H
Q
L
E
G
L
L
S
Q
M
K
A
I
D
D
L
V
-------