@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0005: (2015-12-11 )
MQLCVALDLEKKEDNLSLLQELKGLDLWAKVGLRSFIRDGATFLDEIRKIDGNFKIFLDLKLYDIPYTMANAALECAKLDIDMLTVHLSSAKSALTILMQRLNALKKRPLIMGVSALTSFSEEEFLMVYNAPLKTQAITLSAIGKESGIDGVVCSVFESLAIKEALGKGFLTLTPGIRLDKNDKEDQERVANAKEAKQNLSDFIVVGRPIYQAKEPREVVLELLKDC
Atome Classification :
(27 SA)
---.........10........20........30........40........50..-......60........70..-......80........90---..----.......100...----.--.----..110.......120----.---..--.--.-..130........140.....-..150.......160.......170.......180........190.......200.......210.......220.....----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---M
Q
L
C
V
A
LDLEKKE
D
N
L
S
L
L
Q
E
L
KG
L
D
L
W
A
K
V
G
L
R
S
F
I
R
D
G
A
T
F
L
D
E
I
R
KIDG
N
-
F
K
I
F
L
D
L
K
L
YDI
P
Y
T
M
A
N
A
A
-
L
E
C
A
K
L
D
I
D
M
L
T
V
H
L
S
S
----
A
K
----
S
A
L
T
I
L
M
Q
R
L
N
A
L
----
K
--K----R
P
L
I
M
G
V
S
A
L
TSFSE----E---
E
F
--
L
--
M
-
V
YN-APL
K
T
Q
A
I
T
L
S
AIGKES-GI
D
G
V
V
C
S
V
F
E
S
L
A
I
K
E
A
LGK
G
F
L
T
LTPGIRLD-KND
K
E
D
Q
E
R
V
A
N
A
K
E
A
K
Q
N
L
S
D
F
I
V
VGRPIYQAK
E
P
R
E
V
V
L
E
L
L
KDC----
45
HHSearch
99.02
53%
-137
* C2 *
3RU6
8
PYRF_CAMJE
A:
[25-250]
---
M
K
L
C
V
A
L
D
L
S
T
K
E
E
C
L
Q
L
A
K
E
L
K
N
L
D
I
W
L
K
V
G
L
R
A
Y
L
R
D
G
F
K
F
I
E
E
L
K
K
V
-
D
D
-
F
K
I
F
L
D
L
K
F
H
D
I
P
N
T
M
A
D
A
C
-
E
E
V
S
K
L
G
V
D
M
I
N
I
H
A
S
A
----
G
K
----
I
A
I
Q
E
V
M
T
R
L
S
K
F
----
S
--
K
----
R
P
L
V
L
A
V
S
A
L
T
S
F
D
E
----
E
---
N
F
--
F
--
S
-
I
Y
R
-
Q
K
I
E
E
A
V
I
N
F
S
K
I
S
Y
E
N
-
G
L
D
G
M
V
C
S
V
F
E
S
K
K
I
K
E
H
T
S
S
N
F
L
T
L
T
P
G
I
R
P
F
-
G
--------
V
A
N
L
A
M
A
R
E
N
L
S
D
Y
I
V
V
G
R
P
I
Y
K
N
E
N
P
R
A
V
C
E
K
I
L
N
K
I
----
23
PsiBlast_CBE
98.79
54%
-131
- C2 -
3RU6
9
PYRF_CAMJE
B:
[25-247]
---
M
K
L
C
V
A
L
D
L
S
T
K
E
E
C
L
Q
L
A
K
E
L
K
N
L
D
I
W
L
K
V
G
L
R
A
Y
L
R
D
G
F
K
F
I
E
E
L
K
K
V
D
-
D
-
F
K
I
F
L
D
L
K
F
H
D
I
P
N
T
M
A
D
A
C
-
E
E
V
S
K
L
G
V
D
M
I
N
I
H
A
S
A
----
G
K
----
I
A
I
Q
E
V
M
T
R
L
S
K
F
----
S
--
K
----
R
P
L
V
L
A
V
S
A
L
T
S
F
D
E
----
E
---
N
F
--
F
--
S
-
I
Y
R
-
Q
K
I
E
E
A
V
I
N
F
S
K
I
S
Y
E
N
-
G
L
D
G
M
V
C
S
V
F
E
S
K
K
I
K
E
H
T
S
S
N
F
L
T
L
T
P
G
I
R
P
F
-
G
E
T
------
V
A
N
L
A
M
A
R
E
N
L
S
D
Y
I
V
V
G
R
P
I
Y
K
N
E
N
P
R
A
V
C
E
K
I
L
N
K
I
----
22
PsiBlast_CBE
98.42
54%
-135
- C2 -
3RU6
7
PYRF_CAMJE
C:
[25-247]
---
M
K
L
C
V
A
L
D
L
S
T
K
E
E
C
L
Q
L
A
K
E
L
K
N
L
D
I
W
L
K
V
G
L
R
A
Y
L
R
D
G
F
K
F
I
E
E
L
K
K
V
D
-
D
-
F
K
I
F
L
D
L
K
F
H
D
I
P
N
T
M
A
D
A
C
-
E
E
V
S
K
L
G
V
D
M
I
N
I
H
A
S
A
----
G
K
----
I
A
I
Q
E
V
M
T
R
L
S
K
F
----
S
--
K
----
R
P
L
V
L
A
V
S
A
L
T
S
F
D
E
----
E
---
N
F
--
F
--
S
-
I
Y
R
-
Q
K
I
E
E
A
V
I
N
F
S
K
I
S
Y
E
N
-
G
L
D
G
M
V
C
S
V
F
E
S
K
K
I
K
E
H
T
S
S
N
F
L
T
L
T
P
G
I
R
P
F
-
G
---------
A
N
L
A
M
A
R
E
N
L
S
D
Y
I
V
V
G
R
P
I
Y
K
N
E
N
P
R
A
V
C
E
K
I
L
N
K
I
----
21
PsiBlast_CBE
97.86
54%
-134
- C2 -
3RU6
5
PYRF_CAMJE
D:
[25-247]
---
M
K
L
C
V
A
L
D
L
S
T
K
E
E
C
L
Q
L
A
K
E
L
K
N
L
D
I
W
L
K
V
G
L
R
A
Y
L
R
D
G
F
K
F
I
E
E
L
K
K
V
D
-
D
-
F
K
I
F
L
D
L
K
F
H
D
I
P
N
T
M
A
D
A
C
-
E
E
V
S
K
L
G
V
D
M
I
N
I
H
A
S
A
----
G
K
----
I
A
I
Q
E
V
M
T
R
L
S
K
F
----
S
--
K
----
R
P
L
V
L
A
V
S
A
L
T
S
F
D
E
----
E
---
N
F
--
F
--
S
-
I
Y
R
-
Q
K
I
E
E
A
V
I
N
F
S
K
I
S
Y
E
N
-
G
L
D
G
M
V
C
S
V
F
E
S
K
K
I
K
E
H
T
S
S
N
F
L
T
L
T
P
G
I
R
P
F
-
G
--------
V
A
N
L
A
M
A
R
E
N
L
S
D
Y
I
V
V
G
R
P
I
Y
K
N
E
N
P
R
A
V
C
E
K
I
L
N
K
I
----
1
PsiBlast_PDB
97.76
54%
-136
- C2 -
3RU6
8
PYRF_CAMJE
A:
[25-247]
---
M
K
L
C
V
A
L
D
L
S
T
K
E
E
C
L
Q
L
A
K
E
L
K
N
L
D
I
W
L
K
V
G
L
R
A
Y
L
R
D
G
F
K
F
I
E
E
L
K
K
V
D
-
D
-
F
K
I
F
L
D
L
K
F
H
D
I
P
N
T
M
A
D
A
C
-
E
E
V
S
K
L
G
V
D
M
I
N
I
H
A
S
A
----
G
K
----
I
A
I
Q
E
V
M
T
R
L
S
K
F
----
S
--
K
----
R
P
L
V
L
A
V
S
A
L
T
S
F
D
E
----
E
---
N
F
--
F
--
S
-
I
Y
R
-
Q
K
I
E
E
A
V
I
N
F
S
K
I
S
Y
E
N
-
G
L
D
G
M
V
C
S
V
F
E
S
K
K
I
K
E
H
T
S
S
N
F
L
T
L
T
P
G
I
R
P
F
-
G
--------
V
A
N
L
A
M
A
R
E
N
L
S
D
Y
I
V
V
G
R
P
I
Y
K
N
E
N
P
R
A
V
C
E
K
I
L
N
K
I
----
27
PsiBlast_CBE
81.53
36%
-115
- C2 -
3LDV
1
PYRF_VIBCH
B:
[29-248]
----
K
V
I
V
A
L
D
Y
D
N
L
A
D
A
L
A
F
V
D
K
I
D
P
S
T
C
R
L
K
V
G
K
E
M
F
T
L
F
G
P
D
F
V
R
E
L
H
K
--
R
G
-
F
S
V
F
L
D
L
K
F
H
D
I
P
N
T
C
S
K
A
V
-
K
A
A
A
E
L
G
V
W
M
V
N
V
H
A
S
G
----
G
E
----
R
M
M
A
A
S
R
E
I
L
E
P
Y
G---
K
--
E
----
R
P
L
L
I
G
V
T
V
L
T
S
M
E
S
----
A
---
D
L
Q
G
I
--
G
-
I
L
S
-
A
P
-
Q
D
H
V
L
R
L
A
T
L
T
K
N
A
-
G
L
D
G
V
V
C
S
A
Q
E
A
S
L
L
K
Q
H
L
G
R
E
F
K
L
V
T
P
G
I
R
P
A
-------
Q
R
R
I
M
T
P
A
Q
A
I
A
S
G
S
D
Y
L
V
I
G
R
P
I
T
Q
A
A
H
P
-
E
V
V
L
E
E
I
N
S
S
----
3
PsiBlast_PDB
81.42
36%
-107
- C2 -
3LDV
3
PYRF_VIBCH
A:
[29-248]
----
K
V
I
V
A
L
D
Y
D
N
L
A
D
A
L
A
F
V
D
K
I
D
P
S
T
C
R
L
K
V
G
K
E
M
F
T
L
F
G
P
D
F
V
R
E
L
H
K
--
R
G
-
F
S
V
F
L
D
L
K
F
H
D
I
P
N
T
C
S
K
A
V
-
K
A
A
A
E
L
G
V
W
M
V
N
V
H
A
S
G
----
G
E
----
R
M
M
A
A
S
R
E
I
L
E
P
Y
G---
K
--
E
----
R
P
L
L
I
G
V
T
V
L
T
S
M
E
S
----
A
---
D
L
Q
G
I
--
G
-
I
L
S
-
A
P
-
Q
D
H
V
L
R
L
A
T
L
T
K
N
A
-
G
L
D
G
V
V
C
S
A
Q
E
A
S
L
L
K
Q
H
L
G
R
E
F
K
L
V
T
P
G
I
R
P
A
-
G
S
E
Q
G
D
Q
R
R
I
M
T
P
A
Q
A
I
A
S
G
S
D
Y
L
V
I
G
R
P
I
T
Q
A
A
H
P
-
E
V
V
L
E
E
I
N
S
S
----
4
PsiBlast_PDB
81.06
36%
-117
- C2 -
3UWQ
7
PYRF_VIBCH
A:
[29-248]
----
K
V
I
V
A
L
D
Y
D
N
L
A
D
A
L
A
F
V
D
K
I
D
P
S
T
C
R
L
K
V
G
K
E
M
F
T
L
F
G
P
D
F
V
R
E
L
H
K
--
R
G
-
F
S
V
F
L
D
L
K
F
H
D
I
P
N
T
C
S
K
A
V
-
K
A
A
A
E
L
G
V
W
M
V
N
V
H
A
S
G
----
G
E
----
R
M
M
A
A
S
R
E
I
L
E
P
Y
G---
K
--
E
----
R
P
L
L
I
G
V
T
V
L
T
S
M
E
S
----
A
---
D
L
Q
G
I
--
G
-
I
L
S
-
A
P
-
Q
D
H
V
L
R
L
A
T
L
T
K
N
A
-
G
L
D
G
V
V
C
S
A
Q
E
A
S
L
L
K
Q
H
L
G
R
E
F
K
L
V
T
P
G
I
R
P
A
--------
R
R
I
M
T
P
A
Q
A
I
A
S
G
S
D
Y
L
V
I
G
R
P
I
T
Q
A
A
H
P
-
E
V
V
L
E
E
I
N
S
S
----
46
HHSearch
81.00
33%
-108
- C2 -
2YYU
2
PYRF_GEOKA
A:
[5-234]
---
T
P
F
I
V
A
L
D
F
P
S
K
Q
E
V
E
R
F
L
R
P
F
A
G
T
P
L
F
V
K
V
G
M
E
L
Y
Y
Q
E
G
P
A
I
V
A
F
L
K
E
--
Q
G
-
H
A
V
F
L
D
L
K
L
H
D
I
P
N
T
V
K
Q
A
M
-
K
G
L
A
R
V
G
A
D
L
V
N
V
H
A
A
G
----
G
R
----
R
M
M
E
A
A
I
E
G
L
D
A
G
----
T
PS
G
RM--
R
P
R
C
I
A
V
T
Q
L
T
S
T
D
E
----
R
---
M
L
--
H
--
E
E
L
W
I
S
R
P
L
V
E
T
V
A
H
Y
A
A
L
A
K
E
S
-
G
L
D
G
V
V
C
S
A
N
E
A
A
F
I
K
E
R
C
G
A
S
F
L
A
V
T
P
G
I
R
F
A
-
D
-------
R
V
V
T
P
R
K
A
R
A
L
G
S
D
Y
I
V
I
G
R
S
L
T
R
A
A
D
P
L
R
T
Y
A
R
L
Q
H
E
W
----
42
HHSearch
80.18
36%
-101
- C2 -
1DBT
2
PYRF_BACSU
A:
[4-233]
---
N
L
P
I
I
A
L
D
F
A
S
A
E
E
T
L
A
F
L
A
P
F
Q
Q
E
P
L
F
V
K
V
G
M
E
L
F
Y
Q
E
G
P
S
I
V
K
Q
L
K
E
--
R
N
-
C
E
L
F
L
D
L
K
L
H
D
I
P
T
T
V
N
K
A
M
-
K
R
L
A
S
L
G
V
D
L
V
N
V
H
A
A
G
----
G
K
----
K
M
M
Q
A
A
L
E
G
L
E
E
G
TPAG
K
--
K
----
R
P
S
L
I
A
V
T
Q
L
T
S
T
S
E
----
Q
---
I
M
--
K
--
D
E
L
L
I
E
K
S
L
I
D
T
V
V
H
Y
S
K
Q
A
E
E
S
-
G
L
D
G
V
V
C
S
V
H
E
A
K
A
I
Y
Q
A
V
S
P
S
F
L
T
V
T
P
G
I
R
M
S
-
E
D
A
A
N
D
Q
V
R
V
A
T
P
A
I
A
R
E
K
G
S
S
A
I
V
V
G
R
S
I
T
K
A
E
D
P
V
K
A
Y
K
A
V
R
L
E
W
----
54
Fugue
80.10
35%
-113
- C2 -
1DBT
2
PYRF_BACSU
A:
[1-237]
MKN
N
L
P
I
I
A
L
D
F
A
S
A
E
E
T
L
A
F
L
A
P
F
Q
Q
E
P
L
F
V
K
V
G
M
E
L
F
Y
Q
E
G
P
S
I
V
K
Q
L
K
E
R
---N
C
E
L
F
L
D
L
K
L
H
D
I
P
T
T
V
N
K
A
M
K
-
R
L
A
S
L
G
V
D
L
V
N
V
H
A
A
G
----
G
K
----
K
M
M
Q
A
A
L
E
G
L
E
E
G
TPAG
K
--
K
----
R
P
S
L
I
A
V
T
Q
L
T
S
T
S
E
----
Q
---
I
M
--
K
DE
L
-
L
I
E
-
K
S
L
I
D
T
V
V
H
Y
S
K
Q
A
E
E
-
S
G
L
D
G
V
V
C
S
V
H
E
A
K
A
I
Y
Q
A
V
S
P
S
F
L
T
V
T
P
G
I
R
M
-S
E
D
A
A
N
D
Q
V
R
V
A
T
P
A
I
A
R
E
K
G
S
S
A
I
V
V
G
R
S
I
T
K
A
E
-
D
P
V
K
A
Y
K
A
V
R
L
E
W
E
GI
26
PsiBlast_CBE
79.37
36%
-112
- C2 -
3UWQ
7
PYRF_VIBCH
B:
[29-248]
----
K
V
I
V
A
L
D
Y
D
N
L
A
D
A
L
A
F
V
D
K
I
D
P
S
T
C
R
L
K
V
G
K
E
M
F
T
L
F
G
P
D
F
V
R
E
L
H
K
--
R
G
-
F
S
V
F
L
D
L
K
F
H
D
I
P
N
T
C
S
K
A
V
-
K
A
A
A
E
L
G
V
W
M
V
N
V
H
A
S
G
----
G
E
----
R
M
M
A
A
S
R
E
I
L
E
P
Y
G---
K
--
E
----
R
P
L
L
I
G
V
T
V
L
T
S
M
E
S
----
A
---
D
L
Q
G
I
--
G
-
I
L
S
-
A
P
-
Q
D
H
V
L
R
L
A
T
L
T
K
N
A
-
G
L
D
G
V
V
C
S
A
Q
E
A
S
L
L
K
Q
H
L
G
R
E
F
K
L
V
T
P
G
I
R
P
A
-
G
S
----
Q
R
R
I
M
T
P
A
Q
A
I
A
S
G
S
D
Y
L
V
I
G
R
P
I
T
Q
A
A
H
P
-
E
V
V
L
E
E
I
N
S
S
----
53
Fugue
78.69
36%
-105
- C2 -
1DBT
2
PYRF_BACSU
A:
[1-237]
MKN
N
L
P
I
I
A
L
D
F
A
S
A
E
E
T
L
A
F
L
A
P
F
Q
Q
E
P
L
F
V
K
V
G
M
E
L
F
Y
Q
E
G
P
S
I
V
K
Q
L
K
E
--
R
N
-
C
E
L
F
L
D
L
K
L
H
D
I
P
T
T
V
N
K
A
M
-
K
R
L
A
S
L
G
V
D
L
V
N
V
H
A
A
G
G
K
K
M
M
Q
----
A
A
L
E
G
L
E
E
G
T
P
A
G
----
K
--
K
----
R
P
S
L
I
A
V
T
Q
L
T
S
T
S
E
----
Q
---
I
M
--
K
DE
L
-
L
I
E
-
K
S
L
I
D
T
V
V
H
Y
S
K
Q
A
E
E
S
-
G
L
D
G
V
V
C
S
V
H
E
A
K
A
I
Y
Q
A
V
S
P
S
F
L
T
V
T
P
G
I
R
M
S
-
E
D
A
A
N
D
Q
V
R
V
A
T
P
A
I
A
R
E
K
G
S
S
A
I
V
V
G
R
S
I
T
K
A
E
D
P
V
K
A
Y
K
A
V
R
L
E
W
E
GI-
28
PsiBlast_CBE
77.34
34%
-102
- C2 -
2YYU
2
PYRF_GEOKA
B:
[9-224]
-------
V
A
L
D
F
P
S
K
Q
E
V
E
R
F
L
R
P
F
A
G
T
P
L
F
V
K
V
G
M
E
L
Y
Y
Q
E
G
P
A
I
V
A
F
L
K
--
E
Q
G
-
H
A
V
F
L
D
L
K
L
H
D
I
P
N
T
V
K
Q
A
M
-
K
G
L
A
R
V
G
A
D
L
V
N
V
H
A
A
G
----
G
R
----
R
M
M
E
A
A
I
E
G
L
D
A
G
TPSG
R
--
M
----
R
P
R
C
I
A
V
T
Q
L
T
S
T
D
E
R
M
L
H
E
---
E
L
--
W
--
I
---
S
-
R
P
L
V
E
T
V
A
H
Y
A
A
L
A
K
E
S
-
G
L
D
G
V
V
C
S
A
N
E
A
A
F
I
K
E
R
C
G
A
S
F
L
A
V
T
P
G
I
R
F
A
-
D
D
A
A
----
R
V
V
T
P
R
K
A
R
A
L
G
S
D
Y
I
V
I
G
R
S
L
T
R
A
A
D
P
L
R
T
Y
A
R
L
Q
H
E
W
----
37
HHSearch
76.80
32%
-104
- C2 -
1EIX
2
PYRF_ECOLI
A:
[15-241]
---
S
P
V
V
V
A
L
D
Y
H
N
R
D
D
A
L
A
F
V
D
K
I
D
P
R
D
C
R
L
K
V
G
K
E
M
F
T
L
F
G
P
Q
F
V
R
E
L
Q
Q
--
R
G
-
F
D
I
F
L
D
L
K
F
H
D
I
P
N
T
A
A
H
A
V
-
A
A
A
A
D
L
G
V
W
M
V
N
V
H
A
S
G
----
G
A
----
R
M
M
T
A
A
R
E
A
L
V
P
F
----
G
--
K
D---
A
P
L
L
I
A
V
T
V
L
T
S
M
E
A
----
S
---
D
L
--
V
--
D
-
L
G
M
T
L
S
P
A
D
Y
A
E
R
L
A
A
L
T
Q
K
C
-
G
L
D
G
V
V
C
S
A
Q
E
A
V
R
F
K
Q
V
F
G
Q
E
F
K
L
V
T
P
G
I
R
P
Q
-
G
S
E
A
G
D
Q
R
R
I
M
T
P
E
Q
A
L
S
A
G
V
D
Y
M
V
I
G
R
P
V
T
Q
S
V
D
P
A
Q
T
L
K
A
I
N
A
S
L
----
47
HHSearch
75.83
31%
-104
- C2 -
3LDV
3
PYRF_VIBCH
A:
[28-254]
---
P
K
V
I
V
A
L
D
Y
D
N
L
A
D
A
L
A
F
V
D
K
I
D
P
S
T
C
R
L
K
V
G
K
E
M
F
T
L
F
G
P
D
F
V
R
E
L
H
K
--
R
G
-
F
S
V
F
L
D
L
K
F
H
D
I
P
N
T
C
S
K
A
V
-
K
A
A
A
E
L
G
V
W
M
V
N
V
H
A
S
G
----
G
E
----
R
M
M
A
A
S
R
E
I
L
E
P
Y
----
G
--
K
ER
P
L
L
I
G
V
T
V
L
T
S
M
E
S
A
D
L
----
Q
---
G
I
--
G
--
I
-
L
---
S
A
P
Q
D
H
V
L
R
L
A
T
L
T
K
N
A
-
G
L
D
G
V
V
C
S
A
Q
E
A
S
L
L
K
Q
H
L
G
R
E
F
K
L
V
T
P
G
I
R
P
A
-
G
S
E
Q
G
D
Q
R
R
I
M
T
P
A
Q
A
I
A
S
G
S
D
Y
L
V
I
G
R
P
I
T
Q
A
A
H
P
E
V
V
L
E
E
I
N
S
S
L
----
8
PsiBlast_PDB
75.32
34%
-104
- C2 -
2YYU
2
PYRF_GEOKA
A:
[9-224]
-------
V
A
L
D
F
P
S
K
Q
E
V
E
R
F
L
R
P
F
A
G
T
P
L
F
V
K
V
G
M
E
L
Y
Y
Q
E
G
P
A
I
V
A
F
L
K
--
E
Q
G
-
H
A
V
F
L
D
L
K
L
H
D
I
P
N
T
V
K
Q
A
M
-
K
G
L
A
R
V
G
A
D
L
V
N
V
H
A
A
G
----
G
R
----
R
M
M
E
A
A
I
E
G
L
D
A
G
TPSG
R
--
M
----
R
P
R
C
I
A
V
T
Q
L
T
S
T
D
E
R
M
L
H
E
---
E
L
--
W
--
I
---
S
-
R
P
L
V
E
T
V
A
H
Y
A
A
L
A
K
E
S
-
G
L
D
G
V
V
C
S
A
N
E
A
A
F
I
K
E
R
C
G
A
S
F
L
A
V
T
P
G
I
R
F
A
-
D
-------
R
V
V
T
P
R
K
A
R
A
L
G
S
D
Y
I
V
I
G
R
S
L
T
R
A
A
D
P
L
R
T
Y
A
R
L
Q
H
E
W
----
7
PsiBlast_PDB
74.70
34%
-109
- C2 -
2YYT
-
PYRF_GEOKA
A:
[9-224]
-------
V
A
L
D
F
P
S
K
Q
E
V
E
R
F
L
R
P
F
A
G
T
P
L
F
V
K
V
G
M
E
L
Y
Y
Q
E
G
P
A
I
V
A
F
L
K
--
E
Q
G
-
H
A
V
F
L
D
L
K
L
H
D
I
P
N
T
V
K
Q
A
M
-
K
G
L
A
R
V
G
A
D
L
V
N
V
H
A
A
G
----
G
R
----
R
M
M
E
A
A
I
E
G
L
D
A
G
TPSG
R
--
M
----
R
P
R
C
I
A
V
T
Q
L
T
S
T
D
E
R
M
L
H
E
---
E
L
--
W
--
I
---
S
-
R
P
L
V
E
T
V
A
H
Y
A
A
L
A
K
E
S
-
G
L
D
G
V
V
C
S
A
N
E
A
A
F
I
K
E
R
C
G
A
S
F
L
A
V
T
-----------------
V
T
P
R
K
A
R
A
L
G
S
D
Y
I
V
I
G
R
S
L
T
R
A
A
D
P
L
R
T
Y
A
R
L
Q
H
E
W
----
10
PsiBlast_PDB
74.39
33%
-117
- C2 -
1L2U
-
PYRF_ECOLI
A:
[17-234]
-----
V
V
V
A
L
D
Y
H
N
R
D
D
A
L
A
F
V
D
K
I
D
P
R
D
C
R
L
K
V
G
K
E
M
F
T
L
F
G
P
Q
F
V
R
E
L
Q
Q
--
R
G
-
F
D
I
F
L
D
L
K
F
H
D
I
P
N
T
A
A
H
A
V
-
A
A
A
A
D
L
G
V
W
M
V
N
V
H
A
S
G
----
G
A
----
R
M
M
T
A
A
R
E
A
L
V
P
F
G---
K
--
D
----
A
P
L
L
I
A
V
T
V
L
T
S
M
E
A
----
S
---
D
L
V
D
L
--
G
-
M
T
L
-
S
P
A
D
-
Y
A
E
R
L
A
A
L
T
Q
K
C
-
G
L
D
G
V
V
C
S
A
Q
E
A
V
R
F
K
Q
V
F
G
Q
E
F
K
L
V
T
P
G
I
R
P
Q
----------
I
M
T
P
E
Q
A
L
S
A
G
V
D
Y
M
V
I
G
R
P
V
T
Q
S
V
D
P
A
Q
T
L
K
A
I
N
A
S
L
----
11
PsiBlast_PDB
73.35
32%
-104
- C2 -
1JJK
2
PYRF_ECOLI
A:
[17-234]
-----
V
V
V
A
L
D
Y
H
N
R
D
D
A
L
A
F
V
D
K
I
D
P
R
D
C
R
L
K
V
G
K
E
M
F
T
L
F
G
P
Q
F
V
R
E
L
Q
Q
--
R
G
-
F
D
I
F
L
D
L
K
F
H
D
I
P
N
T
A
A
H
A
V
-
A
A
A
A
D
L
G
V
W
M
V
N
V
H
A
S
G
----
G
A
----
R
M
M
T
A
A
R
E
A
L
V
P
F
G---
K
--
D
----
A
P
L
L
I
A
V
T
V
L
T
S
M
E
A
----
S
---
D
L
--
V
D
-
L
-
G
M
T
-
L
S
P
A
D
Y
A
E
R
L
A
A
L
T
Q
K
C
-
G
L
D
G
V
V
C
S
A
Q
E
A
V
R
F
K
Q
V
F
G
Q
E
F
K
L
V
T
P
G
I
R
P
Q
-
G
S
E
A
G
D
Q
R
R
I
M
T
P
E
Q
A
L
S
A
G
V
D
Y
M
V
I
G
R
P
V
T
Q
S
V
D
P
A
Q
T
L
K
A
I
N
A
S
L
----
30
PsiBlast_CBE
73.26
33%
-101
- C2 -
1EIX
2
PYRF_ECOLI
C:
[17-234]
-----
V
V
V
A
L
D
Y
H
N
R
D
D
A
L
A
F
V
D
K
I
D
P
R
D
C
R
L
K
V
G
K
E
M
F
T
L
F
G
P
Q
F
V
R
E
L
Q
Q
--
R
G
-
F
D
I
F
L
D
L
K
F
H
D
I
P
N
T
A
A
H
A
V
-
A
A
A
A
D
L
G
V
W
M
V
N
V
H
A
S
G
----
G
A
----
R
M
M
T
A
A
R
E
A
L
V
P
F
G---
K
--
D
----
A
P
L
L
I
A
V
T
V
L
T
S
M
E
A
----
S
---
D
L
VD
L
--
G
-
M
T
L
-
S
P
A
D
-
Y
A
E
R
L
A
A
L
T
Q
K
C
-
G
L
D
G
V
V
C
S
A
Q
E
A
V
R
F
K
Q
V
F
G
Q
E
F
K
L
V
T
P
G
I
R
P
Q
-
G
S
E
A
G
D
Q
R
R
I
M
T
P
E
Q
A
L
S
A
G
V
D
Y
M
V
I
G
R
P
V
T
Q
S
V
D
P
A
Q
T
L
K
A
I
N
A
S
L
----
31
PsiBlast_CBE
72.97
33%
-104
- C2 -
1EIX
2
PYRF_ECOLI
B:
[17-234]
-----
V
V
V
A
L
D
Y
H
N
R
D
D
A
L
A
F
V
D
K
I
D
P
R
D
C
R
L
K
V
G
K
E
M
F
T
L
F
G
P
Q
F
V
R
E
L
Q
Q
--
R
G
-
F
D
I
F
L
D
L
K
F
H
D
I
P
N
T
A
A
H
A
V
-
A
A
A
A
D
L
G
V
W
M
V
N
V
H
A
S
G
----
G
A
----
R
M
M
T
A
A
R
E
A
L
V
P
F
G---
K
--
D
----
A
P
L
L
I
A
V
T
V
L
T
S
M
E
A
----
S
---
D
L
VD
L
--
G
-
M
T
L
-
S
P
A
D
-
Y
A
E
R
L
A
A
L
T
Q
K
C
-
G
L
D
G
V
V
C
S
A
Q
E
A
V
R
F
K
Q
V
F
G
Q
E
F
K
L
V
T
P
G
I
R
P
Q
-
G
S
E
A
G
D
Q
R
R
I
M
T
P
E
Q
A
L
S
A
G
V
D
Y
M
V
I
G
R
P
V
T
Q
S
V
D
P
A
Q
T
L
K
A
I
N
A
S
L
----
25
PsiBlast_CBE
72.85
38%
-96
- C2 -
1DBT
2
PYRF_BACSU
B:
[8-223]
-------
I
A
L
D
F
A
S
A
E
E
T
L
A
F
L
A
P
F
Q
Q
E
P
L
F
V
K
V
G
M
E
L
F
Y
Q
E
G
P
S
I
V
K
Q
L
K
--
E
R
N
-
C
E
L
F
L
D
L
K
L
H
D
I
P
T
T
V
N
K
A
M
-
K
R
L
A
S
L
G
V
D
L
V
N
V
H
A
A
G
----
G
K
K
M
M
Q
A
A
L
E
G
L
E
E
G
T
P
A
G
----
K
--
K
----
R
P
S
L
I
A
V
T
Q
L
T
S
T
S
E
----
Q
I
M
K
D
E
--
L
--
L
-
I
E
K
-
S
L
I
D
T
-
V
V
H
Y
S
K
Q
A
E
E
S
-
G
L
D
G
V
V
C
S
V
H
E
A
K
A
I
Y
Q
A
V
S
P
S
F
L
T
V
T
P
G
I
R
M
S
-
E
D
A
A
N
D
Q
V
R
V
A
T
P
A
I
A
R
E
K
G
S
S
A
I
V
V
G
R
S
I
T
K
A
E
D
P
V
K
A
Y
K
A
V
R
L
E
W
----
9
PsiBlast_PDB
72.60
33%
-102
- C2 -
1EIX
2
PYRF_ECOLI
A:
[17-234]
-----
V
V
V
A
L
D
Y
H
N
R
D
D
A
L
A
F
V
D
K
I
D
P
R
D
C
R
L
K
V
G
K
E
M
F
T
L
F
G
P
Q
F
V
R
E
L
Q
Q
--
R
G
-
F
D
I
F
L
D
L
K
F
H
D
I
P
N
T
A
A
H
A
V
-
A
A
A
A
D
L
G
V
W
M
V
N
V
H
A
S
G
----
G
A
----
R
M
M
T
A
A
R
E
A
L
V
P
F
G---
K
--
D
----
A
P
L
L
I
A
V
T
V
L
T
S
M
E
A
----
S
---
D
L
V
D
L
--
G
-
M
T
L
-
S
P
A
D
-
Y
A
E
R
L
A
A
L
T
Q
K
C
-
G
L
D
G
V
V
C
S
A
Q
E
A
V
R
F
K
Q
V
F
G
Q
E
F
K
L
V
T
P
G
I
R
P
Q
-
G
S
E
A
G
D
Q
R
R
I
M
T
P
E
Q
A
L
S
A
G
V
D
Y
M
V
I
G
R
P
V
T
Q
S
V
D
P
A
Q
T
L
K
A
I
N
A
S
L
----
29
PsiBlast_CBE
72.31
33%
-102
- C2 -
1EIX
2
PYRF_ECOLI
D:
[17-234]
-----
V
V
V
A
L
D
Y
H
N
R
D
D
A
L
A
F
V
D
K
I
D
P
R
D
C
R
L
K
V
G
K
E
M
F
T
L
F
G
P
Q
F
V
R
E
L
Q
Q
--
R
G
-
F
D
I
F
L
D
L
K
F
H
D
I
P
N
T
A
A
H
A
V
-
A
A
A
A
D
L
G
V
W
M
V
N
V
H
A
S
G
----
G
A
----
R
M
M
T
A
A
R
E
A
L
V
P
F
G---
K
--
D
----
A
P
L
L
I
A
V
T
V
L
T
S
M
E
A
----
S
---
D
L
VD
L
--
G
-
M
T
L
-
S
P
A
D
-
Y
A
E
R
L
A
A
L
T
Q
K
C
-
G
L
D
G
V
V
C
S
A
Q
E
A
V
R
F
K
Q
V
F
G
Q
E
F
K
L
V
T
P
G
I
R
P
Q
-
G
S
E
A
G
D
Q
R
R
I
M
T
P
E
Q
A
L
S
A
G
V
D
Y
M
V
I
G
R
P
V
T
Q
S
V
D
P
A
Q
T
L
K
A
I
N
A
S
L
----
2
PsiBlast_PDB
71.77
38%
-95
- C2 -
1DBT
2
PYRF_BACSU
A:
[8-223]
-------
I
A
L
D
F
A
S
A
E
E
T
L
A
F
L
A
P
F
Q
Q
E
P
L
F
V
K
V
G
M
E
L
F
Y
Q
E
G
P
S
I
V
K
Q
L
K
--
E
R
N
-
C
E
L
F
L
D
L
K
L
H
D
I
P
T
T
V
N
K
A
M
-
K
R
L
A
S
L
G
V
D
L
V
N
V
H
A
A
G
----
G
K
K
M
M
Q
A
A
L
E
G
L
E
E
G
T
P
A
G
----
K
--
K
----
R
P
S
L
I
A
V
T
Q
L
T
S
T
S
E
----
Q
I
M
K
D
E
--
L
--
L
-
I
E
K
-
S
L
I
D
T
-
V
V
H
Y
S
K
Q
A
E
E
S
-
G
L
D
G
V
V
C
S
V
H
E
A
K
A
I
Y
Q
A
V
S
P
S
F
L
T
V
T
P
G
I
R
M
S
-
E
D
A
A
N
D
Q
V
R
V
A
T
P
A
I
A
R
E
K
G
S
S
A
I
V
V
G
R
S
I
T
K
A
E
D
P
V
K
A
Y
K
A
V
R
L
E
W
----
24
PsiBlast_CBE
71.18
38%
-93
- C2 -
1DBT
1
PYRF_BACSU
C:
[8-223]
-------
I
A
L
D
F
A
S
A
E
E
T
L
A
F
L
A
P
F
Q
Q
E
P
L
F
V
K
V
G
M
E
L
F
Y
Q
E
G
P
S
I
V
K
Q
L
K
--
E
R
N
-
C
E
L
F
L
D
L
K
L
H
D
I
P
T
T
V
N
K
A
M
-
K
R
L
A
S
L
G
V
D
L
V
N
V
H
A
A
G
----
G
K
KMMQ
A
A
L
E
G
L
E
E
G
T
P
A
G
----
K
--
K
----
R
P
S
L
I
A
V
T
Q
L
T
S
T
S
E
----
Q
IMK
D
E
--
L
--
L
-
I
E
K
-
S
L
I
D
T
-
V
V
H
Y
S
K
Q
A
E
E
S
-
G
L
D
G
V
V
C
S
V
H
E
A
K
A
I
Y
Q
A
V
S
P
S
F
L
T
V
T
P
G
I
R
M
S
-
E
D
A
A
N
D
Q
V
R
V
A
T
P
A
I
A
R
E
K
G
S
S
A
I
V
V
G
R
S
I
T
K
A
E
D
P
V
K
A
Y
K
A
V
R
L
E
W
----