@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0008: (2015-12-11 )
MAKEIKFSDSARNLLFEGVRQLHDAVKVTMGPRGRNVLIQKSYGAPSITKDGVSVAKEIELSCPVANMGAQLVKEVASKTADAAGDGTTTATVLAYSIFKEGLRNITAGANPIEVKRGMDKAAEAIINELKKASKKVGGKEEITQVATISANSDHNIGKLIADAMEKVGKDGVITVEEAKGIEDELDVVEGMQFDRGYLSPYFVTNAEKMTAQLDNAYILLTDKKISSMKDILPLLEKTMKEGKPLLIIAEDIEGEALTTLVVNKLRGVLNIAAVKAPGFGDRRKEMLKDIAILTGGQVISEELGLSLENAEVEFLGKAGRIVIDKDNTTIVDGKGHSDDVKDRVAQIKTQIASTTSDYDKEKLQERLAKLSGGVAVIKVGAASEVEMKEKKDRVDDALSATKAAVEEGIVIGGGAALIRAAQKVHLNLHDDEKVGYEIIMRAIKAPLAQIAINAGYDGGVVVNEVQKHEGHFGFNASNGKYVDMFKEGIIDPLKVERIALQNAVSVSSLLLTTEATVHEIKEEKAAPAMPDMGGMGGMGGMGGMM
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420....--..--.430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAK
E
I
KFS
D
S
A
R
N
L
L
F
E
G
V
R
Q
L
H
D
A
V
K
V
TMGPRG
R
N
V
L
I
Q
KSYGAPSITK
D
G
V
S
V
A
K
E
I
E
LSC
P
V
A
N
M
G
A
Q
L
V
K
E
V
A
S
KTADAAGDGT
T
T
A
T
V
L
A
Y
S
I
F
K
E
G
L
R
N
ITAGA
N
P
I
E
V
K
RG
M
D
K
A
A
E
A
I
I
N
E
L
K
K
A
S
K
KVG
G
K
E
E
I
T
Q
V
A
T
I
SANSDH
N
I
G
K
L
I
A
D
A
M
E
K
VGKD
G
V
I
T
V
E
EAKGI
E
D
E
L
D
V
V
EGMQFDRGYLS
P
Y
F
VT
N
A
E
K
M
T
A
QLD
N
A
Y
I
L
L
TD
K
K
I
S
S
M
K
D
I
L
P
L
L
E
K
T
M
KEGK
P
L
L
I
I
AEDIEG
E
A
L
T
T
L
V
V
N
K
L
R
G
V
L
N
I
A
A
VKAPGF
G
D
R
R
K
E
M
L
K
D
I
A
I
LTG
G
Q
V
I
S
E
E
LGLSLENA
E
V
E
F
LGKA
G
R
I
V
I
DKDN
T
T
I
VDGKGH
S
D
D
V
K
D
R
V
A
Q
I
K
T
Q
I
ASTTSDY
D
K
E
K
L
Q
E
R
L
A
K
LSG
G
V
A
V
I
K
VGAAS
E
V
E
M
K
E
K
K
D
R
V
D
D
A
L
S
A
T
K
A
A
V
EE
G
I
V
IGG
G
A
A
L
I
R
A
A
Q
K
V
H
--
L
N
--LHDDEKV
G
Y
E
I
I
M
R
A
I
KA
P
L
A
Q
I
A
I
NAGYDG
G
V
V
V
N
E
V
Q
K
HEGHFGFNASNG
K
Y
V
D
M
F
K
E
GIID
P
L
K
V
E
R
I
A
L
Q
N
A
V
S
V
S
S
L
L
LTT
E
A
T
V
H
E
I
K
E
E
KAAPAMPDMGGMGGMGGMGGMM
197
HHSearch
94.64
61%
-74
- C4 -
1KP8
3
CH60_ECOLI
A:
[1-525]
A
A
K
D
V
K
F
G
N
D
A
G
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
V
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
--
D
L
RG
Q
N
A
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
K
-----------------------
58
PsiBlast_CBE
94.17
60%
-78
- C4 -
3E76
3
CH60_ECOUT
C:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
DL
R
G
--
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
------------------------
59
PsiBlast_CBE
93.79
60%
-79
- C4 -
3E76
6
CH60_ECOUT
B:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
DL
R
G
--
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
------------------------
85
PsiBlast_CBE
93.37
60%
-76
- C4 -
1MNF
3
CH60_ECOLI
B:
[2-525]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
DL
R
G
--
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
K
-----------------------
20
PsiBlast_PDB
93.27
60%
-75
- C4 -
4HEL
-
?
A:
[2-523]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
DL
R
G
--
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
K
-----------------------
83
PsiBlast_CBE
93.26
60%
-75
- C4 -
1MNF
3
CH60_ECOLI
D:
[2-525]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
DL
R
G
--
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
K
-----------------------
109
PsiBlast_CBE
93.25
60%
-78
- C4 -
2YNJ
1
CH60_ECOUT
C:
[2-523]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
DL
R
G
--
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
------------------------
57
PsiBlast_CBE
93.25
60%
-75
- C4 -
3E76
1
CH60_ECOUT
D:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
DL
R
G
--
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
------------------------
13
PsiBlast_PDB
93.22
60%
-76
- C4 -
2EU1
-
CH60_ECOLI
A:
[3-525]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
DL
R
G
--
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
K
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
------------------------
12
PsiBlast_PDB
93.20
60%
-80
- C4 -
3E76
5
CH60_ECOUT
A:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
DL
R
G
--
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
------------------------
75
PsiBlast_CBE
93.19
60%
-76
- C4 -
1MNF
3
CH60_ECOLI
L:
[2-525]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
DL
R
G
--
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
K
-----------------------
11
PsiBlast_PDB
93.16
60%
-77
- C4 -
2NWC
-
CH60_ECOLI
A:
[3-525]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
DL
R
G
--
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
------------------------
80
PsiBlast_CBE
93.13
60%
-76
- C4 -
1MNF
3
CH60_ECOLI
G:
[2-525]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
DL
R
G
--
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
K
-----------------------
98
PsiBlast_CBE
93.09
60%
-78
- C4 -
2YNJ
36
CH60_ECOUT
N:
[2-523]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
DL
R
G
--
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
------------------------
77
PsiBlast_CBE
93.09
60%
-76
- C4 -
1MNF
3
CH60_ECOLI
J:
[2-525]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
DL
R
G
--
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
K
-----------------------
99
PsiBlast_CBE
93.04
60%
-78
- C4 -
2YNJ
36
CH60_ECOUT
M:
[2-523]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
DL
R
G
--
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
------------------------
84
PsiBlast_CBE
93.03
60%
-76
- C4 -
1MNF
3
CH60_ECOLI
C:
[2-525]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
DL
R
G
--
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
K
-----------------------
110
PsiBlast_CBE
93.01
60%
-78
- C4 -
2YNJ
7
CH60_ECOUT
B:
[2-523]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
DL
R
G
--
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
------------------------
18
PsiBlast_PDB
92.97
60%
-78
- C4 -
2YNJ
7
CH60_ECOUT
A:
[2-523]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
DL
R
G
--
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
------------------------
72
PsiBlast_CBE
92.95
60%
-76
- C4 -
1XCK
1
CH60_ECOLI
B:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
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G
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V
A
Q
I
R
Q
Q
I
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A
T
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D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
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G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
DL
R
G
--
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
------------------------