@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0015: (2015-12-11 )
MLEKLLSAIKQKVSNYFLGVLPKSYSMSEENNILGLYDEHFLLTKNENLVGILRLEGVSYTHLSTEQLQDLFTERQMALDSLEKVVARLVVKRRKIDYKQSIQSDSQYLQAILNQFENKEVYENQYFLVLESTHSLHGVLEHKKKSFMHANRENFKDILSYKAHFLQETLKSLEIQLKNYAPKLLNSKEVLNFYAEYINGFELPLKPLVGGYLSDSYIASSITFEKDYFIQESFNQKTYNRLIGIKAYESERITSIAVGALLYQETPLDIIFSIEPMSVNKTLSFLKERAKFSMSNLVKNELLEYQELVKTKRLSMQKFALNVLIKAPSLEDLDAQTSLILGLLFKENLVGVIETFGLKGGYFSFFPERIHLNHRLRFLTSKALACLMVFERQNLGFKANSWGNSPLSVFKNLDYSPFLFNFHNQEVSHNNAKEIARVNGHTLVIGATGSGKSTLISYLMMSALKYQNMRLLAFDRMQGLYSFTEFFKGHYHDGQSFSINPFCLEPNLQNLEFLQSFFLSMLDLAPSRDKEALEDMNAISGAIKSLYETLYPKDFSLLDFKETLKRTSSNQLGLSLEPYLNNPLFNALNDAFNSNAFLNVINLDAITQNPKDLGLLAYYLFYKILEESRKNDSGFLVFLDEFKSYVENDLLNTKINALITQARKANGVVVLALQDIYQLSGVKNAHSFLSNMGTLILYPQKNARELKHNFNVPLSETEISFLENTPLYARQVLVKNLGNGSSNMIDVSLEGLGCYLKIFNSDSSHVNKVKALQKDYPTEWREKLLKS
Atome Classification :
(20 SA)
----------------------------------------------------.........10-----.......--.20....-...----.30........40........50.----......-.--60....---....70---..---.......-----80.---.......90......-----------..100.......--------110.....--..120.......130....------.-----..140.........150--........--.160....--...170.......180.......190.---------......200.......210.........220.......230-------.........240...----....250.......260.......270..-----------------------.....280......---------.290...--....300-....----...310....-----...320.....---..330---.......340......-------.350-.........360.......370.......380------------.......390-----------.......400.......410----------........420..---.....430..-..---...440.......450..--.....460---...---.....470...-....480.......490--...---.....500.......510------....-.....-------------520......----------.530.--------------......540....---------------------------...550...-....560---------------------.......570..----------------------.....580----.......----590..----.---....600.......610.......620-------.......-------------..----630......---------.640......--.--650-....-----..--------------...660.......670......-.680---........690--------------.......700.......710.---......720..----.....730.......740......---------.750..-----.....760----.........770-...-------.....780--.....-------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------
M
L
E
K
L
L
S
A
I
K
Q
-----
K
V
S
N
Y
F
L
--GVLPKSY-SMS----EEN
N
I
L
G
L
YD
E
H
F
L
L
TKNE
N
L
V
G
I
----
L
R
LEGV-
S
--
Y
THL
S
T
---
E
Q
L
Q
D
----
L
F
---
T
E
R
Q
M
A
L
-----
D
S
L
---
E
K
V
V
A
R
L
V
V
K
R
RKI
D
-----------
Y
K
Q
SIQ
S
D
S
Q
Y
L
--------
Q
A
I
L
N
QFE--NK
E
V
YE
N
Q
Y
F
L
V
L
EST
H
S
L
------
H
-----
G
V
L
--
E
H
K
K
K
S
F
M
HA----
N
R
E
N
F
K
D
I
--
L
S
Y
K
A
H
F
L
--
Q
E
T
L
K
S
L
E
I
Q
L
K
NY
A
P
K
LL
N
S
K
E
V
L
N
F
---------
Y
A
E
Y
INGFEL
P
L
K
P
L
V
G
--
G
YLSD
S
Y
IASS
I
T
FEK
D
Y
F
I
---------
Q
E
SFN
Q
K
T
Y
N
R
L
I
G
I
----
K
AYESER
I
T
S
I
A
V
G
A
L
LYQETP
L
D
I
I
F
S
I-----------------------EPMS
V
N
K
T
L
S
F
L
K
E
---------
R
A
K
F
S
M
S
--
N
L
V
K
N
E
L
-
L
E
Y
Q
----
E
L
V
K
T
K
R
L
S
M
-----
Q
K
F
A
L
N
V
L
I
KA---PSLED---L
D
A
Q
T
S
L
I
L
G
L
L
F
K
E
N
-------
L
V
---
G
V
I
E
T
FGLKG
G
Y
F
SF
F
P
E
R
I
H
L
N
H
R
L
R
F
L
T
S
K
------------
A
L
A
C
L
M
V
F
ER-----------QNLGFKANSWGN
S
P
L
S
V
F
K-----------NLDYS
P
F
L
F
N
FHN---QEVSHN
N
A
K
E
-
I
A
---RVNG
H
T
L
V
I
G
ATGS
G
K
S
T
--
L
I
S
Y
L
M
M
----
S
A
L
---
K
YQN
M
R
L
L
A
F
D
-
R
M
Q
G
L
Y
S
F
T
E
F
F
K
GHY---HDG---QSFSIN
P
F
CLEPNL
Q
N
--------
L
E
F
L
-
Q
S
F
F
L
-------------
S
M
L
DLAPSR----------
D
K
E
A
L
--------------
E
D
M
N
A
I
S
G
A
I
K
S
L
---------------------------
Y
E
T
LYPKDF-
S
L
L
D
F
K
E
---------------------
T
L
K
RTSSNQLGL----------------------SLEPYLNN----
P
L
F
N
A
L
N
----
D
AFNS----N---
A
F
L
N
V
I
N
L
D
A
ITQN
P
K
D
L
G
L
L
A
Y
Y
L
---------
F
Y
K
I
L
E
E
-------------SR----KNDS
G
F
L
V
F
---------
L
D
E
F
K
S
Y
V
E
N
--
D
--
L
---
L
N
T
K
-----
I
N
--------------
A
L
I
T
Q
ARKAN
G
V
V
V
L
A
L
Q
D
I
Y
Q
-LS-G---V
K
N
A
H
S
F
L
SNM--------------
G
T
L
I
L
YPQK
N
A
R
E
L
K
H
NFNVP---LSET
E
I
S
FLEN----T
P
L
Y
A
R
Q
V
L
V
K
NLGNGSS
N
M
I
D
V
S
---------LEG
L
G
C
-----
Y
L
K
I
FN------SDS
S
H
V
N
K
V
K
A
--
L
Q
K-------DY
P
T
E
W
R
E
--
K
L
LKS-------------------------------------------------------------------------------
37
Fugue
88.02
19%
-47
- C2 -
5CZZ
7
?
A:
[6-1055]
R
N
Y
I
L
G
L
DIGIT
S
V
G
Y
G
I
I
D
YETRDVI
D
A
G
V
R
L
F
K
EAN
V
E
N
N
E
G
R
R
S
K
R
G
A
R
R
L
K
R
R
R
R
H
R
I
Q
-----
R
V
K
K
L
L
F
D
Y
N
L
L
T
D
H
S
-
E
L
S
GIN
P
Y
E
A
R
V
K
G
L
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Q
K
---
L
S
E
E
E
F
S
A
A
L
----
L
H
L
A
K
R
-
R
--
G
V
H
N
V
N
---
E
V
E
E
D
TGNE
L
S
---
T
K
E
Q
I
S
R
-----
N
S
K
A
L
E
E
K
Y
V
A
E
L
Q
L
E
R
L
K
K
D
GEVRGSINRFK
T
S
D
Y
V
K
E
A
K
Q
L
L
--------
K
V
Q
K
A
Y
H
Q
--
L
D
Q
S
F
I
D
T
Y
I
D
L
L
E
T
R
R
T
Y
------
Y
-----
E
-
G
--
P
G
E
G
S
P
F
G
W
K
----
D
I
K
E
W
Y
E
M
--
L
M
G
H
C
T
Y
F
--
P
E
E
L
R
S
V
K
Y
A
Y
N
A
D
L
Y
N
A
L
N
D
L
N
N
L
V
I
T
R
DENEKLE
Y
Y
E
K
F
Q
I
I
E
N
V
F
K
Q
--
K
--
K
K
P
T
L
K
Q
I
A
K
E
I
L
V
N
E
E
D
I
K
G
Y
R
V
T
STG
K
P
E
F
T
N
L
K
V
Y
H
D
I
K
D
I
TARK
E
I
I
E
N
A
E
L
L
D
Q
I
A
K
I
L
T
I
Y
Q
S
S
E
D
I
Q
E
E
L
-----------------------
T
N
L
N
S
E
L
T
Q
E
E
I
E
Q
I
S
N
LKGY
T
G
T
H
N
L
S
L
K
A
I
N
L
I
L
D
E
L
-
W
H
T
N
DN
Q
I
A
I
F
N
R
L
K
L
V
P
-----
K
K
V
D
L
S
Q
Q
K
E
I
---
P
T
T
L
V
---
D
D
F
I
L
S
P
V
V
K
R
S
F
I
Q
S
-------
I
K
V
I
N
A
I
I
K
K
Y
G
L
P
N
D
I
I
I
E
L
A
R
E
K
N
S
K
D
A
Q
K
M
I
N
E
M
------------
Q
K
R
N
R
Q
T
N
E
R
I
E
E
I
I
------
R
T
T
G
K
E
N
A
K
Y
L
I
E
K
I
K
L
H
D
M
Q
EGKCLYSL
E
A
I
P
L
E
D
L
L
N
N
P
F
N
---
Y
E
V
D
H
I
I
P
R
S
-
V
S
FDN
S
F
N
N
K
V
L
V
K
Q
E
E
A
S
K
K
G
N
--
R
T
P
F
Q
Y
L
S
SSD
S
K
I
---
S
Y
E
T
F
K
K
H
I
L
N
-
L
A
K
G
K
G
R
I
S
K
T
K
K
E
Y
L
L
EE
R
D
I
---
N
R
F
S
V
Q
K
D
F
I
N
R
N
L
V
D
TR
Y
A
T
R
G
L
M
N
L
L
-
R
S
Y
F
R
V
N
NLD
V
K
V
K
S
I
N
G
G
F
T
S
F
L
R
R
K
W
KFKKERNKG
Y
K
H
H
A
--------------
E
D
A
L
I
I
A
N
A
D
F
I
F
K
E
WKKL
D
K
A
K
K
V
M
E
NQMFMPEIET
E
Q
E
Y
K
E
I
F
I
T
P
H
-
Q
I
K
H
I
K
D
FK
D
Y
K
Y
S
H
R
V
D
KKPNRELIND
T
L
Y
S
T
R
K
D
D
K
G
N
----------------------
T
L
I
V
N
N
L
N
----
G
L
Y
D
K
D
N
----
D
K
L
K
K
----
L
---
I
N
K
S
P
E
K
L
L
M
Y
H
H
D
P
Q
T
Y
Q
K
L
K
L
I
M
E
Q
Y
G
DEKN
P
L
Y
K
Y
Y
E
E
TGNYLTKY-----
S
K
----
K
D
N
G
P
V
I
K
K
---------
I
K
Y
Y
G
N
K
L
N
A
--
H
--
L
---
D
I
T
D
DYPNS
R
N
--------------
K
V
V
K
L
S
L
K
P
Y
R
F
D
V
Y
L
D
N
G
V
Y
K
-
F
V
-
T
---
V
K
N
L
D
--
V
I
K
K
--------------
E
N
Y
Y
E
V
N
S
K
A
Y
E
E
A
K
K
L
K
K
I
S
N--
Q
A
E
F
I
A
S
F
Y
N
N
D
L
--
I
K
I
N
G
E
L
Y
R
V
I
G
V
N
N
D
L
L
N
R
I
E
V
N
M
I
DIT
Y
R
E
Y
L
E
N
M
N
D
KRPP
R
I
I
K
T
I
A
------
S
K
T
Q
S
I
K
K
Y
S
T
D
I
L
G
N
-------
L
Y
E
V
K
S
K
K
HP
Q
I
I
K
K
-------------------------------------------------------------------------------
38
Fugue
86.81
16%
-55
* C5 *
3W3W
1
IMB3_YEAST
A:
[3-1077]
-----------------------------------------------ALP
E
E
V
N
R
T
L
L
Q
I
V
Q
A
FASD
N
Q
I
R
S
V
A
E
--
K
A
L
S
E
E
W
I
T
E
N
----
N
I
E
Y
L
L
T
F
L
A
E
Q
A
A
F
S
Q
D
T
T
V
A
A
L
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A
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L
F
R
K
L
A
L
-
K
A
P
I
T
H
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K
---
E
V
L
A
Q
----
I
R
---
S
S
L
L
K
G
F
L
SERA
D
S
I
---
R
H
K
L
S
D
A
I
A
E
C
V
Q
D
D
---------------
L
P
A
W
P
E
L
L
--------
Q
A
L
I
E
S
L
K
SG
N
P
N
F
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S
F
R
I
L
T
T
V
P
Y
L
I
------
T
A
VD
I
N
S
I
L
--
P
I
F
Q
S
G
F
T
D
A
----
S
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V
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A
A
--
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A
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Y
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I
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L
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K
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A
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A
P
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K
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L
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P
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A
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T
T
A
L
E
L
----
L
T
V
F
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N
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P
Q
M
C
K
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N
Q
N
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T
L
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I
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M
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EVSIDDDDA
A
E
W
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SDDTDDE
E
E
V
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H
A
R
Q
A
L
D
R
---------
V
A
L
K
L
G
G
--
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Y
L
A
A
P
L
-
F
Q
Y
L
----
Q
Q
M
I
T
S
T
E
W
R
-----
E
R
F
A
A
M
M
A
L
S
S
A
AE
G
C
A
D
V
---
L
I
G
E
I
P
K
I
L
D
M
V
I
P
L
I
NDPH
P
R
V
Q
Y
---
G
C
C
N
V
L
G
Q
I
S
T
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S
P
F
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H
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A
L
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L
TSECT
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H
A
A
A
A
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V
N
F
S
E
FASKDILEPY
L
D
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N
L
L
V
L
L
Q
S
N
K
L
Y
V
Q
-----------
E
Q
A
L
T
T
I
A
F
I
A
E
A
A
--
K
N
K
F
I
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Y
Y
D
T
-
L
M
---
P
L
L
L
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L
K
V
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V
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K
G
K
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--
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C
A
T
L
I
G
----
F
A
V
---
G
K
E
K
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H
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E
-
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---
Y
L
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---
Q
S
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S
R
I
C
R
I
L
G
D
D
F
V
P
--------
L
--
L
-
P
I
V
I
P
-------------
P
L
L
I
T
A
K
A
T
----------
Q
D
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G
L
IEEEEAANFQQYPD
W
D
V
V
Q
V
Q
G
K
H
I
A
I
---------------------------
H
T
S
V
L
D
D
K
V
-
S
A
M
E
L
L
Q
---------------------
S
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A
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L
L
R
G
Q
F
A
V
----------------------
Y
V
K
E
V
M
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----
I
A
L
P
S
L
D
FYLH
D
G
V
R
A
----
A
---
G
A
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L
I
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I
L
L
S
C
L
L
A
A
E
E
L
V
L
L
W
H
K
A
---------
S
S
K
L
I
G
G
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----
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A
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---
T
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DRDEYNED
F
T
D
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D
L
L
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--
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---
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L
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D
A
R
----
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A
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Y
I
I
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V
C
A
Q
Y
A
P
S
T
Y
A
D
V
C
---------
I
P
T
L
D
T
-----
L
V
Q
I
V
D
GSKLEE
N
R
S
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T
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A
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A
--
I
A
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I
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N
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A
--
N
W
F
K
T
LPTITD
K
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QVCAQSN
I
S
A
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V
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RSLT
V
I
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V
K
K
L
L
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D
A
M
A
I
F
N
RYP
A
D
I
M
E
K
V
H
K
W
F
36
Fugue
70.90
18%
-30
- C4 -
2BVL
8
TOXB_PEPDI
A:
[1-543]
----------------------------------------------------
M
S
L
V
N
R
K
Q
L
E
K
-----
M
A
N
V
R
F
--------
R
T
-
Q
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----
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A
I
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----
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---
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K
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---------
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-----
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---
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-----------
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----
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------------------
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----
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----------
G
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-------
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A
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---
I
------------------------------------
G
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---------------
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----------------------------
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----------------------------------------------------------------
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K
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Y
---------------------------------------
T
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-------------
D
M
L
D
---
E
E
----------
V
Q
S
S
F
--------------
E
S
V
L
A
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S
D
K
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I
---------------------------
F
S
S
L
G
D
M
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A
-
S
P
L
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-----------------------
K
I
A
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G
I
I
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Q
----------------------
G
L
I
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----
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C
S
N
L
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----
K
Q
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----
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---
Y
K
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L
N
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L
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P
A
I
S
E
D
N
D
F
N
T
T
T
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T
F
---------
I
D
S
I
M
A
E
-------------
A
N
----
A
D
N
G
R
F
M
M
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---------
L
G
K
Y
L
R
-------------
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G
F
F
-----
P
D
--------------
V
K
T
T
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N
L
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G
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A
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A
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M
-
F
K
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---
S
M
N
I
H
-------------------------
L
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---------
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K
T
N
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--
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----
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Q
E
M
A
S
L
W
-------------------------------------------------
S
F
D
D
A
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A
--
Q
F
E
-------
E
Y
K
R
N
Y
F
E
--
G
A
L
---------------------------------------------------------------------------------
39
Fugue
70.20
11%
-19
* C3 *
2OCE
-
?
A:
[2-730]
------------------------------------------------------
D
S
I
N
T
R
I
A
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-----
E
L
S
A
L
P
S
--
G
R
V
Q
P
Q
Q
-
V
A
A
----
A
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A
L
L
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----
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---
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Y
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----
L
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---
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-----
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S
I
---
E
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G
K
L
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P
E
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A
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-----------
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A
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----
K
T
R
L
--------
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D
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Y
L
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--
Q
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R
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-
A
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------
A
-----
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----
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------
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--
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-----
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----
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----------------
L
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A
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L
-----------------------
K
V
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A
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---------
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M
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--
F
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----
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-----
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---
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L
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---
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-------
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---
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P
G
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A
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-----------------------------------------------
D
A
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G
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L
L
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-----------
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P
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A
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---
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---
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---
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-------------
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Q
----------
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Q
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---------------
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Q
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K
L
A
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S
L
D
A
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---------------------------
V
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D
C
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N
A
---
V
G
V
D
V
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---------------------
A
S
A
A
L
L
A
R
I
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L
----------------------
N
S
T
L
A
Q
N
I
----
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A
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----
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----
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---
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---------
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A
-------------
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A
----
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---------
Q
R
I
A
A
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-------------
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D
-----
I
R
--------------
S
L
I
G
D
S
A
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R
---------
L
D
-
P
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K
---
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--------------
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---
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P
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D
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P
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N
R
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G
L
S
MRMSDTPG-----------------------------------------------------------------
10
HHSearch
68.84
18%
-71
- C6 -
1E9R
2
?
A:
[35-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
A
K
Q
V
T
V
A
G
V
P
---
M
P
---------
R
D
---
A
E
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L
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N
G
A
T
G
T
G
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--
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L
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L
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Y
----
T
G
L
---
L
-
R
G
D
R
M
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N
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D
M
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K
F
G
R
D
K
D
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I
---
L
N
P
YDQ
R
T
K
G
W
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F
F
N
E
I
R
N
D
Y
D
--------
W
Q
R
Y
A
L
S
V
V
P
-------------
R
G
K
T
--
D
E
A
----------
E
E
W
A
S
--------------
Y
G
R
L
L
L
R
E
T
A
K
K
L
---------------------------
A
L
I
G
---
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P
-
S
M
R
E
L
F
H
---------------------
W
T
T
I
A
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L
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F
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EGTLA
E
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L
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A
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N
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A
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----
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A
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L
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---------
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D
V
V
C
T
S
-------------
I
L
S
LPE
E
P
K
R
R
L
W
L
F
---------
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D
E
L
A
S
L
E
K
L
--
A
---------
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-----
L
A
--------------
D
A
L
T
K
G
R
K
A
G
L
R
V
V
A
G
L
Q
S
T
S
Q
-
L
D
-
D
V
YG
V
K
E
A
Q
T
L
R
A
S
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--------------
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S
L
V
V
L
G
G
S
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K
T
N
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M
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L
---
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----
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V
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M
P
A
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I
A
N
L
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D
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A
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---------
V
G
F
A
G
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-----
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P
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A
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------
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L
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I
K
Q
F
A
N
R
Q
--
P
A
F
-------
V
E
G
T
------------------------------------------------------------------------------------------
43
Fugue
67.93
17%
-46
- C1 -
4Y21
-
?
A:
[1-539]
----------------------------------------------------
G
K
E
R
F
V
K
L
L
D
Q
-----
L
H
N
S
L
R
I
--
D
L
-------------------
S
M
Y
R
N
N
F
P
A
S
S
--------------------------------------------
P
E
R
L
Q
D
L
-----
K
S
T
---
V
D
L
L
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S
I
T
F
F
R
M
K
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Q
-----------
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L
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P
R
A
S
Q
V
V
--------
K
D
C
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-------
K
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C
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N
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C
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L
------
Y
-----
G
R
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T
D
P
A
K
K
G
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V
P
----
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KN
L
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F
W
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I
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D
K
N
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Y
T
P
C
L
N
Q
F
P
Q
E
L
N
---------------------------------------------------------------------------------------------------------
V
-----------------------
G
K
I
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A
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V
M
W
S
L
F
A
Q
---------
D
M
K
Y
A
M
E
--
E
H
D
K
H
R
L
-
C
K
--------------------------------------------------------------------------------------
S
A
D
Y
M
N
L
H
F
K
V
K
W
L
Y
N
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------------
Y
V
A
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L
P
T
F
K
D
-----------------------------
R
-----------
V
P
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Y
P
A
W
F
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---
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----
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---
D
V
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---
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---
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-------------
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P
C
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-------------
L
M
--------------
N
N
T
Q
Q
L
R
V
Q
L
E
K
M
---------------------------
F
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A
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G
K
E
L
-
D
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A
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S
G
---------------------
T
L
K
-----
E
L
Q
V
----------------------
K
L
N
N
V
L
D
E
-----
L
S
H
V
F
A
----
T
S
F
Q
P
----
H
---
I
E
E
C
V
R
Q
M
G
D
I
L
S
Q
V
K
G
T
G
N
V
P
A
S
A
---------
C
S
S
V
A
Q
D
-------------
A
D
----
N
V
L
Q
P
I
M
D
L
---------
L
D
S
N
L
T
L
F
A
K
--
I
--
C
------------------------------------
E
K
T
V
L
K
R
V
L
K
E
L
W
K
-
L
------------
V
M
N
T
M
--------------
E
R
T
I
V
L
P
P
E
F
S
K
L
K
D
H
M
V
R
E
E
AKS
L
T
P
K
Q
C
A
V
V
E
L
----
A
L
D
T
I
K
Q
Y
F
H
A
G
-
G
V
G
L
K
----------------------------
K
T
F
L
------
E
K
S
P
D
L
Q
S
L
R
Y
--
A
L
S
-------
L
Y
-
T
Q
A
T
D
--
L
L
I
K
--------------------------------------------------------------------------------
35
Fugue
66.72
17%
-67
* C4 *
2IUT
3
FTSK_PSEAE
A:
[70-477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
-----------------------
E
V
K
Q
K
S
Y
S
P
E
S
L
E
A
---------
M
S
R
L
L
E
I
--
K
L
K
E
F
G
V
E
V
S
V
D
----
S
V
H
P
G
P
V
I
T
R
-----
F
E
I
Q
P
A
A
G
V
K
V
---
S
R
I
S
N
---
L
A
K
D
L
A
R
S
L
A
V
I
S
-----------
V
---
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
-----
N
E
D
R
Q
M
V
R
F
S
------------
E
V
L
S
S
P
E
Y
D
E
-----------
H
K
S
T
V
--------
P
L
A
L
G
H
-----------
D
I
G
G
R
P
I
I
T
D
L
A
K
---
M
P
------------------
H
L
L
V
A
G
T
T
G
S
G
K
S
V
--
G
V
N
A
M
L
L
----
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
--------------------
P
H
L
L
C
P
V
V
T
D
--------------------------------------------------
M
K
E
A
A
--------------
N
A
L
R
W
S
V
A
E
M
E
R
R
---------------------------
Y
R
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
---------------------
K
V
K
D
A
E
E
A
G
T
P
L
----------------------
T
-
D
P
L
F
R
R
----
E
S
P
D
D
E
P
----
P
Q
L
S
T
----
L
---
P
T
I
-
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
---------
I
A
R
I
A
Q
K
-------------
A
R
----
A
A
G
I
H
L
I
L
A
---------
T
Q
R
P
S
V
D
V
I
T
--
G
--
L
---
I
K
A
N
-----
I
P
--------------
T
R
I
A
F
Q
-------
V
S
S
K
I
D
S
R
T
-
I
L
-
D
---
Q
G
G
A
E
Q
L
L
G
H
G
--------------
D
M
L
Y
L
P
P
G
T
G
L
P
I
R
V
H
G
A
F
V
S
---
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
50.39
23%
-5
- C6 -
2IUS
-
FTSK_ECOLI
A:
[1113-1185]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
Y
I
V
V
L
---------
V
D
E
F
A
D
L
M
M
T
V
G
K
--
K
---
V
E
E
L
-----
I
A
--------------
R
L
A
Q
K
A
R
A
A
G
I
H
L
V
L
A
T
Q
R
P
S
V
D
V
I
-
T
-------
G
L
I
K
A
N
I
--------------
P
T
R
I
A
F
T
V
S
S
K
I
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
41.20
28%
114
- C6 -
2WAQ
-
?
C:
[247-302]
-----------------------------------------------------------------------------------------------------
D
E
Y
I
I
L
T
D
G
S
N
L
S
G
V
----
L
S
V
K
G
V
-
D
--
I
A
K
V
E
T
NNI
R
E
I
E
E
----
V
F
G
I
E
A
A
R
E
I
I
I
-----
R
E
I
---
S
K
V
L
A
E
Q
G
L
D
V
D
M
R
H
-----------
I
L
L
V
A
D
V
M
T
R
T
G
--------
V
V
R
Q
I
G
R
H
--
G
V
T
G
E
K
N
S
V
L
A
R
A
A
F
E
V
T
V
------
K
-----
H
L
L
--
D
A
A
A
R
G
D
V
E
E
----
F
K
G
V
V
E
N
I
--
I
I
G
H
P
I
K
L
--
G
T
G
M
V
E
L
T
M
R
P
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
41.15
20%
-1
- C6 -
2IUT
-
FTSK_PSEAE
A:
[342-413]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
T
I
V
V
V
---------
V
D
E
F
A
D
M
M
M
I
V
G
K
--
K
---
V
E
E
L
-----
I
A
--------------
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
-
D
-------
V
I
T
G
L
I
K
A
N
I
--------------
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
Q
G
---
G
A
E
Q
L
L
G
H
G
D
M
----
L
Y
L
P
P
G
T
G
L
P
I
R
V
H
G
A
F
V
S
D
D
E
V
H
---------
R
V
V
E
A
W
-----
K
L
R
G
A
P
------
D
Y
I
E
D
I
L
A
G
------------------------------------------------------------------------------------------------------------
26
HHSearch
40.31
12%
20
- C6 -
2DR3
-
Y284_PYRHO
A:
[128-198]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
K
R
V
V
---------
V
D
S
V
T
T
L
Y
I
N
--
K
PA
M
---
A
R
S
I
-----
I
L
--------------
Q
L
K
R
V
L
A
G
T
G
C
T
S
I
F
V
S
Q
V
S
------
G
----
F
G
-
P
G
V
E
H
G
V
--------------
D
G
I
I
R
L
D
L
D
E
I
D
G
E
L
K
R
S
L
I
V
---
W
K
M
R
G
T
S
H
S
M
R
----
R
H
P
F
D
I
T
D
K
G
I
I
V
Y
P
D
K
V
L
K
R
--------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
40.18
28%
113
- C6 -
2PMZ
-
RPOA2_SULSO
C:
[244-299]
-----------------------------------------------------------------------------------------------------
D
E
Y
I
I
L
T
D
G
S
N
L
S
G
V
----
L
S
V
K
G
V
-
D
--
V
A
K
V
E
T
NN
I
R
E
I
E
E
----
V
F
G
I
E
A
A
R
E
I
I
I
-----
R
E
I
---
S
K
V
L
A
E
Q
G
L
D
V
D
I
R
H
-----------
I
L
L
I
A
D
V
M
T
R
T
G
--------
I
V
R
Q
I
G
R
H
--
G
V
T
G
E
K
N
S
V
L
A
R
A
A
F
E
V
T
V
------
K
-----
H
L
L
--
D
A
A
A
R
G
D
V
E
E
----
F
K
G
V
V
E
N
I
--
I
I
G
H
P
I
K
L
--
G
T
G
M
V
E
L
T
M
R
P
I
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
38.77
28%
99
- C6 -
2WB1
-
?
C:
[247-302]
-----------------------------------------------------------------------------------------------------
D
E
Y
I
I
L
T
D
G
S
N
L
S
G
V
----
L
S
V
K
G
V
-
D
--
I
A
K
V
E
T
NNI
R
E
I
E
E
----
V
F
G
I
E
A
A
R
E
I
I
I
-----
R
E
I
---
S
K
V
L
A
E
Q
G
L
D
V
D
M
R
H
-----------
I
L
L
V
A
D
V
M
T
R
T
G
--------
V
V
R
Q
I
G
R
H
--
G
V
T
G
E
K
N
S
V
L
A
R
A
A
F
E
V
T
V
------
K
-----
H
L
L
--
D
A
A
A
R
G
D
V
E
E
----
F
K
G
V
V
E
N
I
--
I
I
G
H
P
I
K
L
--
G
T
G
M
V
E
L
T
M
R
P
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
38.16
28%
101
- C6 -
4AYB
-
?
C:
[247-302]
-----------------------------------------------------------------------------------------------------
D
E
Y
I
I
L
T
D
G
S
N
L
S
G
V
----
L
S
V
K
G
V
-
D
--
I
A
K
V
E
T
NNI
R
E
I
E
E
----
V
F
G
I
E
A
A
R
E
I
I
I
-----
R
E
I
---
S
K
V
L
A
E
Q
G
L
D
V
D
M
R
H
-----------
I
L
L
V
A
D
V
M
T
R
T
G
--------
V
V
R
Q
I
G
R
H
--
G
V
T
G
E
K
N
S
V
L
A
R
A
A
F
E
V
T
V
------
K
-----
H
L
L
--
D
A
A
A
R
G
D
V
E
E
----
F
K
G
V
V
E
N
I
--
I
I
G
H
P
I
K
L
--
G
T
G
M
V
E
L
T
M
R
P
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
37.66
11%
11
- C6 -
2R2A
-
?
A:
[86-152]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
G
S
I
V
I
---------
V
D
E
A
Q
D
V
W
P
A
--
R
--
S
AGS
K
I
P
E
-----
N
V
--------------
Q
W
L
N
T
H
R
H
Q
G
I
D
I
F
V
L
T
Q
G
P
K
L
-
L
D
---------
Q
N
L
R
T
L
V
--------------
R
K
H
Y
H
I
A
S
N
K
M
G
M
R
T
L
L
E
W
K
I
---
C
A
D
D
P
V
K
M
A
S
S
----
A
F
S
S
I
Y
T
L
D
K
K
V
Y
D
L
Y
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
37.52
28%
104
- C6 -
2Y0S
-
?
C:
[247-302]
-----------------------------------------------------------------------------------------------------
D
E
Y
I
I
L
T
D
G
S
N
L
S
G
V
----
L
S
V
K
G
V
-
D
--
I
A
K
V
E
T
NNI
R
E
I
E
E
----
V
F
G
I
E
A
A
R
E
I
I
I
-----
R
E
I
---
S
K
V
L
A
E
Q
G
L
D
V
D
M
R
H
-----------
I
L
L
V
A
D
V
M
T
R
T
G
--------
V
V
R
Q
I
G
R
H
--
G
V
T
G
E
K
N
S
V
L
A
R
A
A
F
E
V
T
V
------
K
-----
H
L
L
--
D
A
A
A
R
G
D
V
E
E
----
F
K
G
V
V
E
N
I
--
I
I
G
H
P
I
K
L
--
G
T
G
M
V
E
L
T
M
R
P
I
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
34.80
25%
69
- C6 -
3GHG
-
FIBG_HUMAN
C:
[32-126]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
T
K
V
D
K
D
L
Q
S
L
--------
E
D
I
L
H
Q
V
E
--
N
K
T
S
E
V
K
Q
L
I
K
A
I
Q
L
T
Y
N
P
------
D
----------
E
S
S
K
P
N
M
I
D
A
A
T
L
K
S
R
K
M
L
E
E
I
--
M
K
Y
E
A
S
I
L
T
H
D
S
S
I
R
Y
L
Q
E
I
Y
N
S
N
N
Q
K
I
V
N
L
K
E
K
V
A
Q
---------
L
E
A
Q
C
Q
E
P
C
K
D
T
V
Q
I
H
D
--
I
T
G
K
D
C
Q
D
I
A
N
K
G
A
K
Q
S
G
L
Y
---------
F
I
K
P
L
K
A
N
Q
Q
F
L
V
Y
C
----
E
I
D
G
S
G
N
G
W
T
V
F
Q
K
R
L
D
G
S
V
D
F
K
K
N
W
I
Q
Y
-----------------------
K
E
G
F
G
H
L
S
P
T
G
T
T
E
---------
F
W
L
G
N
E
K
--
I
H
L
I
S
T
Q
-
S
A
I
P
----
Y
A
L
R
V
E
L
E
D
W
-----
N
G
R
T
S
T
A
D
Y
A
M
---
F
K
V
G
P
---
E
A
D
K
Y
R
L
T
Y
A
Y
F
A
G
G
D
-------
A
G
---
D
A
F
D
G
F
D
F
G
D
D
P
S
D
K
F
F
T
S
H
N
G
M
Q
F
S
T
W
D
N
D
N
------------
D
K
F
E
G
N
C
A
E
Q
-----------
D
G
S
G
W
W
M
N
K
C
H
A
G
H
L
N
G
V
Y
-----------
Y
Q
G
G
T
Y
S
K
A
S
T
P
N
---
G
Y
D
N
G
I
I
W
A
T
-
W
K
---
T
R
W
Y
S
M
K
K
T
T
M
K
I
I
P
F
N
R
--
L
T
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
34.70
28%
113
- C6 -
3HKZ
-
RPOA2_SULSO
C:
[247-302]
-----------------------------------------------------------------------------------------------------
D
E
Y
I
I
L
T
D
G
S
N
L
S
G
V
----
L
S
V
K
G
V
-
D
--
V
A
K
V
E
T
NN
I
R
E
I
E
E
----
V
F
G
I
E
A
A
R
E
I
I
I
-----
R
E
I
---
S
K
V
L
A
E
Q
G
L
D
V
D
I
R
H
-----------
I
L
L
I
A
D
V
M
T
R
T
G
--------
I
V
R
Q
I
G
R
H
--
G
V
T
G
E
K
N
S
V
L
A
R
A
A
F
E
V
T
V
------
K
-----
H
L
L
--
D
A
A
A
R
G
D
V
E
E
----
F
K
G
V
V
E
N
I
--
I
I
G
H
P
I
K
L
--
G
T
G
M
V
E
L
T
M
R
P
I
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
30.89
40%
227
- C6 -
4PHT
2
?
A:
[220-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
M
R
-----------
L
L
D
K
N
A
T
R
L
D
L
H
S
L
G
M
T
P
V
N
H
D
N
F
R
H
L
I
S
---
R
P
H
G
I
I
L
V
T
G
P
T
G
S
G
K
S
T
--
T
L
Y
A
G
L
Q
----
E
L
N
---
S
N
E
R
N
I
L
T
V
E
D
-
P
I
E
F
D
I
D
G
I
G
Q
T
Q
V
N
P
---
K
V
D
---
M
T
F
A
R
G
L
R
A
I
L
R
Q
D
P
D
--------
V
V
M
V
-
G
E
I
R
D
-------------
L
E
T
A
Q
I
A
V
Q
----------
A
S
L
T
G
--------------
H
L
V
M
S
T
L
H
T
N
T
A
V
---------------------------
G
A
I
T
R
L
R
D
M
-
G
I
E
P
F
L
I
---------------------
S
S
S
L
L
G
V
L
A
Q
R
L
----------------------
V
R
T
L
C
Q
D
C
----
K
E
P
Y
E
A
D
----
K
E
Q
R
K
----
L
---
F
A
L
T
L
Y
R
A
K
G
C
E
K
C
N
H
K
G
Y
R
G
R
T
G
I
---------
H
E
L
L
M
V
D
-------------
D
K
----
V
Q
E
L
I
H
A
E
A
---------
G
E
Q
A
M
D
K
Y
I
R
--
E
--
H
---
T
P
S
I
-----
R
S
--------------
D
G
L
D
K
V
L
Q
G
V
T
S
L
E
E
V
M
R
V
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
29.52
19%
106
- C3 -
3ZBD
-
R1A_CVPPU
A:
[-4-105]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
S
S
K
Q
F
K
I
L
V
N
-----------------------
E
D
Y
Q
V
N
-
V
P
S
L
P
I
R
---------
D
V
L
Q
E
I
K
--
Y
C
Y
R
N
G
F
-
E
G
Y
V
----
F
V
P
E
Y
C
R
D
L
V
DCDRK
D
H
Y
V
I
G
V
L
G
N
G
---
V
S
D
L
K
P
V
L
L
T
E
P
S
V
M
L
Q
G
F
I
V
R
A
N
-------
C
N
---
G
V
L
E
D
F
D
L
K
I
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------