@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0016: (2015-12-11 )
MKIFVLLMSVILGISLTGCIGYRMDLEHFNTLYYEESPKKAYEYSKQFTKKKKNALLWDLQNGLSALYARDYKTSLGVLDQAEQRFDKTQSAFTRGAGYVGATMINDNVRAYGGNIYEGVLINYYKAIDYMLLNDSAKARVQFNRANERQRRAKEFYYEEVQKAIKEIDSSKKHNINMERSRAEVSEILNNTYSNLDKYEAYQGLLNPAVSYLSGLFYALNGDKNKGLGYLNEAYGISQSPFVAQDLVFFKNPNRSHFTWIIIEDGKEPQKSEFKIDVPIFMIDSVYNVSVALPKLEKGEAFYQNFTLKDGEKVTPFDTLASIDAVVASEFRKQLPYIITRAILSATFKVGMQAVANYYLGFVGGLVTSLYSGVSTFADTRNTSIFAHKIYLMRIKNKAFESYEVRADSIDAFSFSLKPCKRSLESPKIIDARELLSGFVTAPQVFCSNRHNILYVRSFKNGFVLSHLK
Atome Classification :
(20 SA)
.........10........20........30........40.......-.50--.-..---.....60........70---........---.80.......-.90.---..---.----..----...100.......110......---------.120.......130-----..----...--....140.......150--......---.---------.--.------------160.----------.......170.......180.......190.......200...-.---...210.......220.-------..------....230.....-..240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
I
F
V
L
L
M
S
V
I
L
G
I
S
L
T
G
CIG
Y
R
M
D
L
E
H
F
N
T
L
YYEES
P
K
K
A
Y
E
Y
S
K
Q
F
-
T
K
K
--K-KN---
A
L
L
W
D
L
Q
N
G
L
S
A
L
Y
A
R
----
D
YKTSLG
V
---
L
D
Q
A
E
Q
R
F
D
K
-
T
Q
-
S
---
A
F
---T----RG----AG
Y
V
G
A
T
M
INDNVRAYGGNI
Y
E
---------
G
V
L
I
N
Y
Y
K
A
I
D
Y
-------
M
L
----LND--SA
K
A
R
V
Q
FNRA
N
E
R
Q
----
R
R
A
K
E
F
---
Y
---------
Y
--
E
------------
E
-
V
Q
----------
K
A
I
K
E
I
DSSKKHNI
N
M
E
R
S
R
A
E
V
S
E
I
L
N
N
T
YSN
L
D
K
Y
E
A
Y
Q
G
L
-
L
---
N
P
A
V
S
Y
L
S
G
L
F
Y
ALNGD-------KN------KGLGY
L
N
E
AYGI-SQSP
F
V
A
Q
D
L
V
F
FKNPNR
S
H
F
T
W
I
I
I
EDGKEPQKS
E
F
K
IDV
P
I
F
M
I
D
S
V
Y
N
V
S
VALPKLEKG
E
A
F
Y
Q
NFTLKDGEKVT
P
F
D
T
L
A
S
I
D
A
V
V
A
S
E
F
R
K
Q
L
P
Y
I
I
T
R
A
I
L
S
A
T
F
K
V
G
M
Q
A
V
A
N
Y
Y
L
G
F
V
G
G
L
V
T
S
L
Y
S
G
V
S
T
F
ADTRN
T
S
I
F
A
H
K
I
Y
L
M
R
IKNKAFE
S
Y
E
V
RADSI
D
A
FSF
S
L
K
P
C
K
R
SLESPKII
D
A
R
E
L
L
S
G
F
V
T
A
P
Q
V
F
CSNRH
N
I
L
Y
V
R
SFKN
G
F
V
LSHLK
21
HHSearch
72.60
15%
0
- C2 -
2Q7F
-
YRRB_BACSU
A:
[43-228]
----------------------------------------
A
A
E
A
F
T
K
A
--
I
E
--
E
N
K
E
---
D
A
I
P
Y
I
N
F
A
N
L
L
S
S
V
N
----
E
L
E
R
A
L
A
F
---
Y
D
K
A
L
E
L
D
S
S
-
A
A
T
A
Y
Y
-
G
A
---
G
----
N
V
Y
V
V
K
E
M
Y
K
E
A
K
D
M
F
E
K
A
L
R
A
G
M
E
------------
N
G
D
L
F
Y
M
L
G
T
V
L
-------
V
K
----
L
E
Q
--
P
K
L
A
L
P
Y
L
Q
R
A
V
E
L
N
----
E
N
D
T
E
A
---
R
---------
F
------------------
Q
----------
F
G
M
C
L
A
N
E
G
---------
M
L
D
E
A
L
S
Q
F
A
A
--------
V
T
E
Q
D
P
-
G
---
H
A
D
A
F
Y
N
A
G
V
T
Y
A
Y
K
E
N
-------
R
E
------
K
A
L
E
M
L
D
K
A
I
D
I
Q
P
D
H
M
L
A
L
H
A
K
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
70.31
13%
22
- C2 -
3U4T
-
?
A:
[232-401]
-------------------------
F
R
Y
A
D
F
L
F
K
N
N
N
Y
A
E
A
I
E
V
F
N
K
L
--
E
A
--
K
K
Y
N
---
S
P
Y
I
Y
N
R
R
A
V
C
Y
Y
E
L
A
----
K
Y
D
L
A
Q
K
D
---
I
E
T
Y
F
S
K
V
N
A
-
T
K
--------------------------------------
A
-------------
K
S
A
D
F
E
Y
Y
G
K
I
L
-------
M
K
----
K
G
Q
--
D
S
L
A
I
Q
Q
Y
Q
A
A
V
D
R
D
----
T
T
R
L
D
M
---
Y
---------
G
--
Q
--------------------------
I
G
S
Y
F
Y
N
K
G
N
---------
F
P
L
A
I
Q
Y
M
E
K
--------
Q
I
R
P
T
T
-
T
---
D
P
K
V
F
Y
E
L
G
Q
A
Y
Y
Y
N
K
E
-------
Y
V
------
K
A
D
S
S
F
V
K
V
L
E
L
K
P
N
I
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
68.74
23%
2
- C3 -
3S5K
-
?
A:
[1034-1191]
--------------------------------------------------------
K
N
---
S
Y
L
W
D
T
V
R
G
L
N
G
A
Y
G
V
F
A
D
I
E
Y
D
G
S
V
V
F
---
L
S
A
R
D
P
N
L
E
K
-
T
L
-
A
---
T
F
R
E
S
A
----
K
G
----
L
R
K
M
A
D
T
M
T
E
N
D
L
L
R
Y
I
I
N
T
I
----------
G
T
I
D
K
P
R
R
G
I
E
L
S
K
L
S
F
L
R
L
I
----
S
N
E
--
S
E
Q
D
R
V
E
F
-
R
K
R
I
M
N
----
T
K
K
E
D
F
---
Y
K
F
A
D
L
L
E
S
K
V
--
N
------------
E
-
F
E
----------
K
N
I
V
I
I
T
T
K
E
K
A
N
E
Y
I
A
N
V
D
G
E
F
K
K
V
L
I
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
67.16
12%
3
- C2 -
3VTX
1
?
A:
[10-175]
--------------------------
D
I
G
D
K
K
R
T
K
G
D
F
D
G
A
I
R
A
Y
K
K
V
--
L
K
--
A
D
P
N
---
N
V
E
T
L
L
K
L
G
K
T
Y
M
D
I
G
----
L
P
N
D
A
I
E
S
---
L
K
K
F
V
V
L
D
T
T
-
S
------------------------------------------------------
A
E
A
Y
Y
I
L
G
S
A
N
-------
F
M
----
I
D
E
--
K
Q
A
A
I
D
A
L
Q
R
A
I
A
L
N
----
T
V
Y
A
D
A
---
Y
---------
Y
--
K
--------------------------
L
G
L
V
Y
D
S
M
G
---------
E
H
D
K
A
I
E
A
Y
E
K
--------
T
I
S
I
K
P
-
G
---
F
I
R
A
Y
Q
S
I
G
L
A
Y
E
G
K
G
L
-------
R
D
------
E
A
V
K
Y
F
K
K
A
L
E
K
E
E
K
K
A
K
Y
E
L
A
L
V
P
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
63.35
12%
-9
- C2 -
2Y4T
-
DNJC3_HUMAN
A:
[40-222]
------------------------
H
L
E
L
G
K
K
L
L
A
A
G
Q
L
A
D
A
L
S
Q
F
H
A
A
--
V
D
--
G
D
P
D
---
N
Y
I
A
Y
Y
R
R
A
T
V
F
L
A
M
G
----
K
S
K
A
A
L
P
D
---
L
T
K
V
I
Q
L
K
M
D
-
F
------------------------------------------------------
T
A
A
R
L
Q
R
G
H
L
L
-------
L
K
----
Q
G
K
--
L
D
E
A
E
D
D
F
K
K
V
L
K
S
N
----
P
S
E
N
E
E
---
K
---------
E
--
A
Q
S
Q
L
I
K
S
D
E
M
Q
R
L
-
R
S
----------
Q
A
L
N
A
F
G
S
G
---------
D
Y
T
A
A
I
A
F
L
D
K
--------
I
L
E
V
C
V
-
W
---
D
A
E
L
R
E
L
R
A
E
C
F
I
K
E
G
E
-------
P
R
------
K
A
I
S
D
L
K
A
A
S
K
L
K
N
D
N
T
E
A
F
Y
K
I
S
T
L
Y
Y
Q
L
G
D
H
E
L
S
L
S
E
V
R
E
C
L
K
L
D
Q
D
H
K
R
C
F
A
H
Y
K
Q
V
K
K
L
N
K
L
I
E
S
A
E
E
L
I
R
D
G
R
Y
T
D
A
T
S
K
Y
E
S
V
M
K
T
E
P
S
I
A
E
Y
T
V
R
S
K
E
R
I
C
H
C
F
S
K
D
E
K
P
V
E
A
I
R
V
C
S
E
V
L
Q
M
E
P
D
N
V
N
A
L
K
D
R
A
E
A
Y
L
I
E
E
M
Y
D
E
A
I
Q
D
Y
E
T
A
Q
E
H
N
E
N
D
Q
Q
I
R
E
G
L
E
K
A
Q
R
L
L
K
Q
S
Q
K
R
D
Y
Y
K
I
L
G
V
K
R
N
A
K
K
Q
E
I
I
K
A
Y
R
K
L
A
L
Q
W
H
P
D
N
F
Q
N
E
E
E
K
K
K
A
E
K
K
F
I
D
I
A
A
A
K
E
V
L
S
33
HHSearch
62.74
8%
7
- C2 -
2YHC
1
BAMD_ECOLI
A:
[7-218]
------------------------
I
Y
A
T
A
Q
Q
K
L
Q
D
G
N
W
R
Q
A
I
T
Q
L
E
A
L
--
D
N
--
R
Y
P
F
GPY
S
Q
Q
V
Q
L
D
L
I
Y
A
Y
Y
K
N
A
----
D
L
P
L
A
Q
A
A
---
I
D
R
F
I
R
L
N
P
T
-
H
P
-
N
--------------------------------------------------
I
D
Y
V
M
Y
M
R
G
L
T
N
-------
M
A
L
D
DD
P
Q
Q
--
A
R
A
A
F
S
D
F
S
K
L
V
R
G
Y
----
P
N
S
Q
Y
T
T
D
A
T
---------
K
--
R
L
V
F
L
K
D
R
L
A
K
Y
-
E
-
Y
S
----------
V
A
E
Y
Y
T
E
R
G
---------
A
W
V
A
V
V
N
R
V
E
G
--------
M
L
R
D
Y
P
-
D
T
Q
A
T
R
D
A
L
P
L
M
E
N
A
Y
R
Q
M
Q
M
-------
N
A
------
Q
A
E
K
V
A
K
I
I
A
A
N
S
S
N
T
L
E
H
H
H
H
H
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
62.13
11%
2
- C2 -
2VQ2
6
?
A:
[12-217]
-------------------------
T
Q
L
A
M
E
Y
M
R
G
Q
D
Y
R
Q
A
T
A
S
I
E
D
A
--
L
K
--
S
D
P
K
---
N
E
L
A
W
L
V
R
A
E
I
Y
Q
Y
L
K
----
V
N
D
K
A
Q
E
S
---
F
R
Q
A
L
S
I
K
P
D
-
S
A
E
I
N
N
N
Y
G
---
W
F
L
C
G
R
L
----
N
R
P
A
E
S
M
A
Y
F
D
K
A
L
A
-
D
P
T
Y
P
T
---------
P
Y
I
A
N
L
N
K
G
I
C
S
-------
A
K
----
Q
G
Q
--
F
G
L
A
E
A
Y
L
K
R
S
L
A
A
Q
----
P
Q
F
P
P
A
---
F
---------
K
------------------
E
----------
L
A
R
T
K
M
L
A
G
Q
---------
L
G
D
A
D
Y
Y
F
K
K
--------
Y
Q
S
R
V
E
V
L
---
Q
A
D
D
L
L
L
G
W
K
I
A
K
A
L
G
N
-------
A
Q
------
A
A
Y
E
Y
E
A
Q
L
Q
A
N
F
P
Y
S
E
E
L
Q
T
V
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
61.10
23%
9
* C3 *
3S5I
-
?
A:
[1034-1191]
--------------------------------------------------------
K
N
---
S
Y
L
W
D
T
V
R
G
L
N
G
A
Y
G
V
F
A
D
I
E
Y
D
G
S
V
V
F
---
L
S
A
R
D
P
N
L
E
K
-
T
L
-
A
---
T
F
R
E
S
A
----
K
G
----
L
R
K
M
A
D
T
M
T
E
N
D
L
L
R
Y
I
I
N
T
I
----------
G
T
I
D
K
P
R
R
G
I
E
L
S
K
L
S
F
L
R
L
I
----
S
N
E
--
S
E
Q
D
R
V
E
F
-
R
K
R
I
M
N
----
T
K
K
E
D
F
---
Y
K
F
A
D
L
L
E
S
K
V
--
N
------------
E
-
F
E
----------
K
N
I
V
I
I
T
T
K
E
K
A
N
E
Y
I
A
N
V
D
G
E
F
K
K
V
L
I
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
60.51
10%
-5
- C2 -
1XNF
1
NLPI_ECOLI
A:
[9-177]
-------------------------
E
V
L
A
V
P
L
Q
P
T
L
Q
Q
E
V
I
L
A
R
M
E
Q
I
L
A
S
R
AL
T
D
D
E
---
R
A
Q
L
L
Y
E
R
G
V
L
Y
D
S
L
G
----
L
R
A
L
A
R
N
D
---
F
S
Q
A
L
A
I
R
P
D
-
M
------------------------------------------------------
P
E
V
F
N
Y
L
G
I
Y
L
-------
T
Q
----
A
G
N
--
F
D
A
A
Y
E
A
F
D
S
V
L
E
L
D
----
P
T
Y
N
Y
A
---
H
---------
L
------------------
N
----------
R
G
I
A
L
Y
Y
G
G
---------
R
D
K
L
A
Q
D
D
L
L
A
--------
F
Y
Q
D
D
P
-
N
---
D
P
F
R
S
L
W
L
Y
L
A
E
-
Q
K
L
D
-------
E
K
------
Q
A
K
E
V
L
K
Q
H
F
E
K
S
D
K
E
Q
W
G
W
N
I
V
E
F
Y
L
G
N
I
S
E
Q
T
L
M
E
R
L
K
A
D
A
T
D
N
T
S
L
A
E
H
L
S
E
T
N
F
Y
L
G
K
Y
Y
L
S
L
G
D
L
D
S
A
T
A
L
F
K
L
A
V
A
N
N
V
H
N
F
V
E
H
R
Y
A
L
L
E
L
S
L
L
G
Q
D
---------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
59.82
12%
-9
- C2 -
3FRV
-
CHMP3_HUMAN
A:
[8-140]
------------------------------------------------------------------------------------------------------------------------------------------
Q
E
K
P
P
K
E
L
V
N
---------
E
W
S
L
K
I
R
K
E
M
R
V
-------
V
D
----
R
Q
I
--
R
D
I
Q
R
E
E
E
K
V
K
R
S
V
K
----
D
A
A
K
K
G
---
Q
---------
K
--
D
------------
V
-
C
I
----------
V
L
A
K
E
M
I
R
S
R
K
A
V
S
K
L
Y
A
S
K
A
H
M
N
S
V
-
L
M
G
M
K
N
Q
L
A
V
L
R
V
A
G
S
-
L
---
Q
K
S
T
E
V
M
K
A
M
Q
S
L
V
K
I
P
-------
E
I
Q
A
T
M
--
R
E
L
S
K
E
M
M
K
A
G
I
-
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
58.59
10%
4
- C2 -
1XNF
1
NLPI_ECOLI
A:
[47-247]
-------------------------
Y
E
R
G
V
L
Y
D
S
L
G
L
R
A
L
A
R
N
D
F
S
Q
A
--
L
A
--
I
R
P
D
---
M
P
E
V
F
N
Y
L
G
I
Y
L
T
Q
A
G
----
N
F
D
A
A
Y
E
A
---
F
D
S
V
L
E
L
D
P
T
-
Y
N
Y
A
H
L
-
N
R
---
G
----
I
A
L
Y
Y
G
G
R
D
K
L
A
Q
D
D
L
L
A
F
Y
Q
D
D
P
N
------------
D
P
F
R
S
L
W
L
Y
L
A
E
--------
Q
----
K
L
D
--
E
K
Q
A
K
E
V
L
K
Q
H
F
E
K
S
----
D
K
E
Q
W
G
---
W
---------
N
--
I
------------
V
-
E
F
----------
Y
-
L
G
N
I
S
E
------------
Q
T
L
M
E
R
L
K
A
D
----
A
T
D
N
T
S
L
A
E
-
H
---
L
S
E
T
N
F
Y
L
G
K
Y
Y
L
S
L
G
D
-------
L
D
------
S
A
T
A
L
F
K
L
A
V
A
N
N
V
H
N
F
V
E
H
R
Y
A
L
L
E
L
S
L
L
G
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
56.81
9%
-7
- C2 -
3AS5
1
?
A:
[13-177]
--------------------------
D
K
G
I
S
H
A
K
A
G
R
Y
S
Q
A
V
M
L
L
E
Q
V
--
Y
D
--
A
D
A
F
---
D
V
D
V
A
L
H
L
G
I
A
Y
V
K
T
G
----
A
V
D
R
G
T
E
L
---
L
E
R
S
L
A
D
A
P
D
-
N
------------------------------------------------------
V
K
V
A
T
V
L
G
L
T
Y
-------
V
Q
----
V
Q
K
--
Y
D
L
A
V
P
L
L
I
K
V
A
E
A
N
----
P
I
N
F
N
V
---
R
---------
F
------------------
R
----------
L
G
V
A
L
D
N
L
G
---------
R
F
D
E
A
I
D
S
F
K
I
--------
A
L
G
L
R
P
-
N
---
E
G
K
V
H
R
A
I
A
F
S
Y
E
Q
M
G
R
-------
H
E
------
E
A
L
P
H
F
K
K
A
N
E
L
D
E
G
A
S
V
E
L
A
L
V
P
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
56.27
13%
-2
- C2 -
1FCH
2
PEX5_HUMAN
A:
[133-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
L
M
A
L
A
V
S
F
-------
T
N
----
E
S
L
--
Q
R
Q
A
C
E
I
L
R
D
W
L
R
Y
T
----
P
A
Y
A
H
L
---
V
---------
T
------------------
R
----------
I
L
G
S
L
L
S
D
S
---------
L
F
L
E
V
K
E
L
F
L
A
--------
A
V
R
L
D
P
-
T
SI-
D
P
D
V
Q
C
G
L
G
V
L
F
N
L
S
G
E
-------
Y
D
------
K
A
V
D
C
F
T
A
A
L
S
V
R
P
N
D
Y
L
L
W
N
K
L
G
A
T
L
A
N
G
N
Q
S
E
E
A
V
A
A
Y
R
R
A
L
E
L
Q
P
G
Y
I
R
S
R
Y
N
L
G
I
S
C
I
N
L
G
A
H
R
E
A
V
E
H
F
L
E
A
L
N
M
Q
R
K
S
G
G
A
M
S
E
N
I
W
S
T
L
R
L
A
L
S
M
L
G
Q
S
D
A
Y
G
A
A
D
A
R
D
L
S
T
L
L
T
M
F
G
L
P
Q
---------------------------------------------------------------------------------------------------------------------
30
HHSearch
54.56
7%
12
- C2 -
2H6F
6
FNTA_HUMAN
A:
[103-274]
---------------------------
F
R
A
V
L
Q
R
D
E
R
S
E
R
A
F
K
L
T
R
D
A
--
I
E
--
L
N
A
A
---
N
Y
T
V
W
H
F
R
R
V
L
L
K
S
L
Q
K---
D
L
H
E
E
M
N
Y
---
I
T
A
I
I
E
E
Q
P
K
-
N
------------------------------------------------------
Y
Q
V
W
H
H
R
R
V
L
V
-------
E
W
----
L
R
D
--
P
S
Q
E
L
E
F
I
A
D
I
L
N
Q
D
----
A
K
N
Y
H
A
---
W
---------
Q
--
H
--------------------------
R
Q
W
V
I
Q
E
F
K
---------
L
W
D
N
E
L
Q
Y
V
D
Q
--------
L
L
K
E
D
V
-
R
---
N
N
S
V
W
N
Q
R
Y
F
V
I
S
N
T
T
G
-------
Y
N
D
R
A
V
L
E
R
E
V
Q
Y
T
L
E
M
I
K
L
V
P
H
N
E
S
A
W
N
Y
L
K
G
I
L
Q
D
R
G
L
S
K
Y
P
N
L
L
N
Q
L
L
D
L
Q
P
S
H
S
S
P
Y
L
I
A
F
L
V
D
I
Y
E
D
M
L
E
N
Q
C
D
N
K
E
D
I
L
N
K
A
L
E
L
C
E
I
L
A
K
E
K
D
T
I
R
K
E
Y
W
R
Y
I
G
R
S
L
Q
S
K
H
S
T
-------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
53.87
12%
7
- C2 -
3IEG
-
DNJC3_MOUSE
A:
[41-223]
-------------------------
L
E
L
G
K
K
L
L
A
A
G
Q
L
A
D
A
L
S
Q
F
H
A
A
--
V
D
--
G
D
P
D
---
N
Y
I
A
Y
Y
R
R
A
T
V
F
L
A
M
G
----
K
S
K
A
A
L
P
D
---
L
T
K
V
I
A
L
K
M
D
-
F
------------------------------------------------------
T
A
A
R
L
Q
R
G
H
L
L
-------
L
K
----
Q
G
K
--
L
D
E
A
E
D
D
F
K
K
V
L
K
S
N
----
P
S
E
Q
E
E
---
K
---------
E
A
E
S
------------
Q
-
L
V
K
A
D
E
M
Q
R
L
R
S
Q
A
L
D
A
F
D
G
A
---------
D
Y
T
A
A
I
T
F
L
D
K
--------
I
L
E
V
C
V
-
W
---
D
A
E
L
R
E
L
R
A
E
C
F
I
K
E
G
E
-------
P
R
------
K
A
I
S
D
L
K
A
A
S
K
L
K
S
D
N
T
E
A
F
Y
K
I
S
T
L
Y
Y
Q
L
G
D
H
E
L
S
L
S
E
V
R
E
C
L
K
L
D
Q
D
H
K
R
C
F
A
H
Y
K
Q
V
K
K
L
N
K
L
I
E
S
A
E
E
L
I
R
D
G
R
Y
T
D
A
T
S
K
Y
E
S
V
M
K
T
E
P
S
V
A
E
Y
T
V
R
S
K
E
R
I
C
H
C
F
S
K
D
E
K
P
V
E
A
I
R
I
C
S
E
V
L
Q
M
E
P
D
N
V
N
A
L
K
D
R
A
E
A
Y
L
I
E
E
M
Y
D
E
A
I
Q
D
Y
E
A
A
Q
E
H
N
E
N
D
Q
Q
I
R
E
G
L
E
K
A
Q
R
L
L
K
Q
S
Q
K
R
---------------------------------------------------------
8
PsiBlast_PDB
53.51
30%
18
- C4 -
4XK8
-
?
F:
[87-168]
--------------------------------------------
S
K
Q
F
-
A
K
R
--
E
-
K
Q
---
A
L
K
-
K
L
Q
A
S
L
K
-
L
Y
A
D
----
D
S
A
P
A
L
A
I
K
A
T
M
E
K
T
K
K
R
F
D
N
Y
G
K
-
Y
---
G
L
---
L
----
C
G
----
S
D
G
L
P
H
L
I
V
S
G
D
Q
R
H
W
G
E
F
I
T
P
---------
G
I
L
F
L
Y
I
A
G
W
I
G
-------
W
V
----
G
R
S
--
Y
L
I
A
I
R
D
E
K
K
P
T
Q
K
E
----
I
I
I
D
V
P
---
L
---------
A
--
S
------------
R
-
L
L
----------
F
R
G
F
S
W
P
V
A
A
Y
R
E
L
L
N
G
E
L
V
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
53.23
7%
16
- C2 -
3Q7A
5
?
A:
[60-243]
---------------------------
F
R
A
I
A
A
K
E
E
K
S
E
R
A
L
E
L
T
E
I
I
--
V
R
--
M
N
P
A
---
H
Y
T
V
W
Q
Y
R
F
S
L
L
T
S
L
N
K---
S
L
E
D
E
L
R
L
---
M
N
E
F
A
V
Q
N
L
K
-
S
------------------------------------------------------
Y
Q
V
W
H
H
R
L
L
L
L
-------
D
R
----
I
S
P
QD
P
V
S
E
I
E
Y
I
H
G
S
L
L
P
D
----
P
K
N
Y
H
T
---
W
---------
A
--
Y
--------------------------
L
H
W
L
Y
S
H
F
S
T
L
G
R
-
I
S
E
A
Q
W
G
S
E
L
D
W
C
N
E
--------
M
L
R
V
D
G
-
R
---
N
N
S
A
W
G
W
R
W
Y
L
R
V
S
R
P
G
AETS
S
R
S
L
Q
------
D
E
L
I
Y
I
L
K
S
I
H
L
I
P
H
N
V
S
A
W
N
Y
L
R
G
F
L
K
H
F
S
L
P
L
V
P
I
L
P
A
I
L
P
Y
T
A
F
P
M
P
S
P
L
P
E
D
T
P
L
P
V
P
L
A
L
E
Y
L
A
D
S
F
I
E
Q
N
R
V
D
D
A
A
K
V
F
E
K
L
S
S
E
Y
D
Q
M
R
A
G
Y
W
E
F
R
R
R
E
C
A
-----------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
50.71
5%
-6
- C2 -
2Y4T
-
DNJC3_HUMAN
A:
[160-379]
---------------------------
Q
A
L
N
A
F
G
S
G
D
Y
T
A
A
I
A
F
L
D
K
I
--
L
E
--
V
C
V
W
---
D
A
E
L
R
E
L
R
A
E
C
F
I
K
E
G
----
E
P
R
K
A
I
S
D
---
L
K
A
A
S
K
L
K
N
D
-
N
T
E
A
F
Y
-
K
I
---
S
----
T
L
Y
Y
Q
L
G
D
H
E
L
S
L
S
E
V
R
E
C
L
K
L
D
Q
D
H
K
R
C
F
A
H
Y
K
Q
V
K
K
L
N
K
L
I
E
S
A
E
E
L
-------
I
R
----
D
G
R
--
Y
T
D
A
T
S
K
Y
E
S
V
M
K
T
E
----
P
S
I
A
E
Y
---
T
---------
V
--
R
------------
S
K
E
R
----------
I
C
H
C
F
S
K
D
E
---------
K
P
V
E
A
I
R
V
C
S
E
--------
V
L
Q
M
E
P
-
D
---
N
V
N
A
L
K
D
R
A
E
A
Y
L
I
E
E
M
-------
Y
D
------
E
A
I
Q
D
Y
E
T
A
Q
E
H
N
E
N
D
Q
Q
I
R
E
G
L
E
K
A
Q
R
L
L
K
Q
S
Q
K
R
D
Y
Y
K
I
L
G
V
K
R
N
A
K
K
Q
E
I
I
K
A
Y
R
K
L
A
L
Q
W
H
P
D
N
F
Q
N
E
E
E
K
K
K
A
E
K
K
F
I
D
I
A
A
A
K
E
V
L
S
D
P
E
M
R
---------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
50.62
30%
85
- C2 -
3LY8
-
CADC_ECOLI
A:
[335-406]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
T
N
F
Y
Q
A
H
D
Y
-------
L
L
----
H
G
D
--
D
K
S
----
L
N
R
A
S
E
L
L
G
E
I
V
Q
S
S
P
E
F
---
T
---------
Y
--
A
------------
R
-
A
E
----------
K
A
L
V
D
I
V
R
H
S
Q
H
P
L
D
E
K
Q
L
A
A
L
N
T
E
I
D
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
50.37
9%
13
- C2 -
2HO1
-
?
A:
[41-244]
-------------------------
I
Q
L
G
L
G
Y
L
Q
R
G
N
T
E
Q
A
K
V
P
L
R
K
A
--
L
E
--
I
D
P
S
---
S
A
D
A
H
A
A
L
A
V
V
F
Q
T
E
-----
E
P
K
L
A
D
E
E
---
Y
R
K
A
L
A
S
D
S
R
-
N
A
R
V
L
N
-
N
Y
---
G
----
G
F
L
Y
E
Q
K
R
Y
E
E
A
Y
Q
R
L
L
E
A
S
Q
D
-
T
L
Y
P
E
---------
R
S
R
V
F
E
N
L
G
L
V
S
-------
L
Q
----
M
K
K
--
P
A
Q
A
K
E
Y
F
E
K
S
L
R
L
N
----
R
N
Q
P
S
V
---
A
---------
L
------------------
E
----------
M
A
D
L
L
Y
K
E
R
---------
E
Y
V
P
A
R
Q
Y
Y
D
L
--------
F
A
Q
G
G
G
-
Q
---
N
A
R
S
L
L
L
G
I
R
L
A
K
V
F
E
D
-------
R
D
------
T
A
A
S
Y
G
L
Q
L
K
R
L
Y
P
G
S
L
E
Y
Q
E
F
Q
A
E
K
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