@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0018: (2015-12-11 )
MKKYSAIPTPCYALESERLEKNAKILEIVRQQSGAKVLLALKGYAFWREFGILRQKLNGCCASGLYEAKLAFEEFGGRESHKEICVYSPAFKEAEMSAILPLATSIIFNSFHQYATYKDRILDKNKQLENLGLSPIKMGLRINPLYSEVTPAIYNPCSKMSRLGITPSGFEKGVKEHGLEGVSGLHFHTHCEQNADALCRTLEHVERHFKPYLENMAWVNFGGGHHITRSDYDVNLLIQTIKDFKERYHNTEVILEPGEAIGWQCGFLIASVIDIVQNDQEIAILDASFSAHMPDCLEMPYRPSILKVSVENDEEIIEVEKGENQGAFSYFLGGPTCLAGDFMGSFSFETPLKRGDKIVFQDMLHYTIVKNNSFNGVPLPSLAKIDSQGFKILKSFSYEDYKNRN
Atome Classification :
(20 SA)
-----------........-.10........20.-.......30.--------.......40........50.-.....----..60........70........---80........90.......---.100.--.-.-....110.......120.......130.......140.......150.......160.......170-.--...---.---...-180-......-----.190-..-.....-200........210---.----.----.---.....220.......230------.----..-----...------...240....-----.------.----.-250.......260.......270...-..-.-----.-------------------------------------------------------------------------------280.......290-.......-300--.-----.--.-...---..310.......320.......330........340..--.--------....350.---.......360.....-..370-......-.380....--.-.--.-390...-....400...-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MKKYSAIP-T
P
C
Y
AL
E
S
E
R
L
EKN-
A
K
I
L
E
I
V
R
Q
Q--------SG
A
K
V
L
L
A
LK
G
Y
A
F
W
R
E
F
G
I
-
L
R
Q
K
L
----
N
G
C
C
ASG
L
Y
E
A
K
L
A
F
E
EFGGRE---SH
K
E
I
C
V
YSPAF
K
E
A
E
M
S
A
---
I
L
P
L
A
--
T
-
S
-
I
I
F
N
S
F
H
Q
Y
A
T
Y
K
D
R
ILDKNK
Q
L
E
NLGL
S
P
I
K
MG
L
R
IN
P
L
Y
S
EV
T
P
A
I
Y
N
P
C
S
K
M
SRLGI
T
P
S
G
F
E
--
K
--
G
V
K
---
E
---HGL-EGV-SGL
H
F
H-----T
H
C
E-Q
N
-
A
D
A
L
C
-
R
T
-
L
E
H
V
E
R
H
F
K
P
----
Y
----
L
----
E
---NM
A
W
V
NFGGGH
H
I
TRS--------D----Y
D
-----
V
N
L
------
L
I
Q
T
I
K
D
F
K
E
-----R------Y----H-N
T
E
V
I
LEPGEAIG
W
Q
C
G
F
L
I
A
S
V
I
D
I
-VQ-N-----D-------------------------------------------------------------------------------Q
E
I
A
I
L
DASFSAH-M
P
D
C
LEM-P-Y--R-----P--
S
-
I
L
K
---
V
SVEND
E
E
I
I
E
V
EKGENQG
A
F
S
Y
F-LGGP
T
C
L
A
G
D
F
MG--S--------FSFETP-L---KRG
D
K
I
V
F
Q
DML
H
Y
T
-
I
VKNN-SFNGVP-L
P
S
L
A
K
ID--S-Q--
G
-
F
K
I
L
K
S
-FSYEDYKNRN-
1
PsiBlast_PDB
98.00
46%
-116
- C3 -
3N29
4
NSPC_CAMJ8
A:
[39-418]
--------------
Y
E
K
I
Q
-
T
P
A
Y
I
L
E
E
D
K
L
R
K
N
-
C
E
L
L
A
S
V
G
E
K
--------
S
G
A
K
V
L
L
A
L
K
G
F
A
F
S
G
A
M
K
I
-
V
G
E
Y
L
----
K
G
C
T
C
S
G
L
W
E
A
K
F
A
K
E
Y
M
--------
D
K
E
I
H
T
Y
S
P
A
F
K
E
D
E
I
G
E
---
I
A
S
L
S
--
H
-
H
-
I
V
F
N
S
L
A
Q
F
H
K
F
Q
S
K
T
-
Q
K
N
S
-----------
L
G
L
R
C
N
V
E
F
S
----------
G
R
Y
S
R
L
G
I
R
A
K
D
F
E
--
N
------------
V
D
L
-
N
A
I
-
E
G
L
H
F
H
-----
A
L
C
E
-
E
S
-
A
D
A
L
E
-
A
V
-
L
K
V
F
E
E
K
F
G
K
----
W
----
I
----
G
---
Q
M
K
W
V
N
F
G
G
G
H
H
I
T
K
K
--------
G
----
Y
D
-----
V
E
K
------
L
I
A
L
C
K
N
F
S
D
-----
K
------
Y
------
G
V
Q
V
Y
L
E
P
G
E
A
V
G
W
Q
T
G
N
L
V
A
S
V
V
D
I
-
I
E
-
N
-----
E
-------------------------------------------------------------------------------
K
Q
I
A
I
L
D
T
S
S
E
A
H
-
M
P
D
T
I
I
M
-
P
-
Y
--
T
-----
S
--
E
-
V
L
N
ARI
L
A
T
R
E
N
E
K
I
S
D
L
K
E
N
E
----
F
A
Y
L
-
L
T
G
N
T
C
L
A
G
D
V
M
G
--
E
--------
Y
A
F
D
K
K
-
L
---
K
I
G
D
K
I
V
F
L
D
Q
I
H
Y
T
-
I
V
K
N
T
-
T
F
N
G
I
R
-
L
P
N
L
M
L
L
D
--
H
-
K
--
N
E
L
Q
M
I
R
E
-
F
S
Y
K
D
Y
S
L
R
N
-
21
PsiBlast_CBE
96.57
46%
-115
- C3 -
3N29
4
NSPC_CAMJ8
B:
[42-418]
-----------------
I
Q
-
T
P
A
Y
I
L
E
E
D
K
L
R
K
N
-
C
E
L
L
A
S
V
G
E
K
--------
S
G
A
K
V
L
L
A
L
K
G
F
A
F
S
G
A
M
K
I
-
V
G
E
Y
L
----
K
G
C
T
C
S
G
L
W
E
A
K
F
A
K
E
Y
M
--------
D
K
E
I
H
T
Y
S
P
A
F
K
E
D
E
I
G
E
---
I
A
S
L
S
--
H
-
H
-
I
V
F
N
S
L
A
Q
F
H
K
F
Q
S
K
T
-
Q
K
N
S
-----------
L
G
L
R
C
N
V
E
F
S
----------
G
R
Y
S
R
L
G
I
R
A
K
D
F
E
--
N
------------
V
D
L
-
N
A
I
-
E
G
L
H
F
H
-----
A
L
C
E
-
E
S
-
A
D
A
L
E
-
A
V
-
L
K
V
F
E
E
K
F
G
K
----
W
----
I
----
G
---
Q
M
K
W
V
N
F
G
G
G
H
H
I
T
K
K
--------
G
----
Y
D
-----
V
E
K
------
L
I
A
L
C
K
N
F
S
D
-----
K
------
Y
------
G
V
Q
V
Y
L
E
P
G
E
A
V
G
W
Q
T
G
N
L
V
A
S
V
V
D
I
-
I
E
-
N
-----
E
-------------------------------------------------------------------------------
K
Q
I
A
I
L
D
T
S
S
E
A
H
-
M
P
D
T
I
I
M
-
P
-
Y
--
T
-----
S
--
E
-
V
L
N
ARI
L
A
T
R
E
N
E
K
I
S
D
L
K
E
N
E
----
F
A
Y
L
-
L
T
G
N
T
C
L
A
G
D
V
M
G
--
E
--------
Y
A
F
D
K
K
-
L
---
K
I
G
D
K
I
V
F
L
D
Q
I
H
Y
T
-
I
V
K
N
T
-
T
F
N
G
I
R
-
L
P
N
L
M
L
L
D
--
H
-
K
--
N
E
L
Q
M
I
R
E
-
F
S
Y
K
D
Y
S
L
R
N
-
24
HHSearch
95.58
49%
-109
- C3 -
3N29
4
NSPC_CAMJ8
A:
[39-418]
--------------
Y
E
K
I
Q
-
T
P
A
Y
I
L
E
E
D
K
L
R
K
N
-
C
E
L
L
A
S
V
G
E
K
--------
S
G
A
K
V
L
L
A
L
K
G
F
A
F
S
G
A
M
K
I
-
V
G
E
Y
L
----
K
G
C
T
C
S
G
L
W
E
A
K
F
A
K
E
Y
-
M
D
-------
K
E
I
H
T
Y
S
P
A
F
K
E
D
E
I
G
E
---
I
A
S
L
S
--
H
-
H
-
I
V
F
N
S
L
A
Q
F
H
K
F
Q
S
K
T
------------
Q
K
N
S
L
G
L
R
C
N
V
E
F
S
----------
G
R
Y
S
R
L
G
I
R
A
K
D
F
E
--
N
------------
V
D
L
-
N
A
I
-
E
G
L
H
F
H
-----
A
L
C
E
-
E
S
-
A
D
A
L
E
-
A
V
-
L
K
V
F
E
E
K
F
G
K
----
W
----
I
----
G
---
Q
M
K
W
V
N
F
G
G
G
H
H
I
T
K
K
--------
G
----
Y
D
-----
V
E
K
------
L
I
A
L
C
K
N
F
S
D
-----
K
-----------
Y
-
G
V
Q
V
Y
L
E
P
G
E
A
V
G
W
Q
T
G
N
L
V
A
S
V
V
D
I
-
I
E
-
N
-----
E
-------------------------------------------------------------------------------
K
Q
I
A
I
L
D
T
S
S
E
A
H
-
M
P
D
T
I
I
M
-
P
-
Y
--
T
S
E
V
L
N
A
--
R
-
I
L
A
---
T
R
E
N
E
------
K
I
S
D
L
K
E
N
E
F
A
Y
L
-
L
T
G
N
T
C
L
A
G
D
V
M
G
--
E
Y
-------
A
F
D
K
-
K
-
L
---
K
I
G
D
K
I
V
F
L
D
Q
I
H
Y
T
-
I
V
K
N
T
-
T
F
N
G
I
R
-
L
P
N
L
M
L
L
D
--
H
K
N
--
E
-
L
Q
M
I
R
E
-
F
S
Y
K
D
Y
S
L
R
N
-
30
HHSearch
87.23
35%
-108
- C3 -
3MT1
1
?
A:
[2-364]
-----------------
I
E
-
T
P
Y
Y
L
I
D
K
A
K
L
T
R
N
-
M
E
R
I
A
H
V
R
E
K
--------
S
G
A
K
A
L
L
A
L
K
C
F
A
T
W
S
V
F
D
L
-
M
R
D
Y
M
----
D
G
T
T
S
S
S
L
F
E
V
R
L
G
R
E
R
F
-
G
K
------
E
T
H
A
Y
S
-
V
A
Y
G
D
N
E
I
D
E
---
V
V
S
H
A
--
D
-
K
-
I
I
F
N
S
I
S
Q
L
E
R
F
A
D
K
A
------------
A
G
I
A
R
G
L
R
L
N
P
Q
----------------
R
L
G
E
W
D
V
P
K
-------
V
E
-------
R
V
M
-
D
R
I
-
N
G
F
M
I
H
-----
N
N
---
N
K
D
F
G
L
F
D
-
R
M
-
L
G
E
I
E
E
R
F
G
A
----
L
----
I
----
A
---
R
V
D
W
V
S
L
G
G
G
I
H
F
T
G
D
--------
D
----
Y
P
-----
V
D
A
------
F
S
A
R
L
R
A
F
S
D
-----
R
------
Y
------
G
V
Q
I
Y
L
E
P
G
E
A
S
I
T
K
S
T
T
L
E
V
T
V
L
D
T
-
L
Y
-
N
-----
G
-------------------------------------------------------------------------------
K
N
L
A
I
V
D
S
S
I
E
A
H
-
M
L
D
L
L
I
Y
-
R
-
E
--
T
-----
A
--
K
-
V
L
P
-------------------
N
E
G
S
H
S
Y
M
-
I
C
G
K
S
C
L
A
G
D
V
F
G
--
E
F
-------
R
F
A
E
-
E
-
L
---
K
V
G
D
R
I
S
F
Q
D
A
A
G
Y
T
-
M
V
K
K
N
-
W
F
N
G
V
K
-
M
P
A
I
A
I
R
E
--
L
D
G
--
S
-
V
R
T
V
R
E
-
F
T
Y
A
D
Y
E
Q
S
L
-
2
PsiBlast_PDB
86.86
33%
-109
- C3 -
3MT1
1
?
A:
[2-361]
-----------------
I
E
-
T
P
Y
Y
L
I
D
K
A
K
L
T
R
N
-
M
E
R
I
A
H
V
R
E
K
--------
S
G
A
K
A
L
L
A
L
K
C
F
A
T
W
S
V
F
D
L
-
M
R
D
Y
M
----
D
G
T
T
S
S
S
L
F
E
V
R
L
G
R
E
R
F
G
--------
K
E
T
H
A
Y
S
V
A
Y
G
D
N
E
I
D
E
---
V
V
S
H
A
--
D
-
K
-
I
I
F
N
S
I
S
Q
L
E
R
F
A
D
K
A
------------
A
G
I
A
R
G
L
R
L
N
P
Q
----------------
R
L
G
----
E
W
D
--
V
--
P
K
V
---
E
---
R
V
M
-
D
R
I
-
N
G
F
M
I
H
-----
N
N
---
N
K
-
D
F
G
L
F
D
R
M
-
L
G
E
I
E
E
R
F
G
A
----
L
----
I
----
A
---
R
V
D
W
V
S
L
G
G
G
I
H
F
T
G
D
--------
D
----
Y
P
-----
V
D
A
------
F
S
A
R
L
R
A
F
S
D
-----
R
------
Y
------
G
V
Q
I
Y
L
E
P
G
E
A
S
I
T
K
S
T
T
L
E
V
T
V
L
D
T
-
L
Y
-
N
-----
G
-------------------------------------------------------------------------------
K
N
L
A
I
V
D
S
S
I
E
A
H
-
M
L
D
L
L
I
Y
-
R
-
E
--
T
-----
A
--
K
-
V
L
P
-------------------
N
E
G
S
H
S
Y
M
-
I
C
G
K
S
C
L
A
G
D
V
F
G
--
E
--------
F
R
F
A
E
E
-
L
---
K
V
G
D
R
I
S
F
Q
D
A
A
G
Y
T
-
M
V
K
K
N
-
W
F
N
G
V
K
-
M
P
A
I
A
I
R
E
--
L
-
D
--
G
S
V
R
T
V
R
E
-
F
T
Y
A
D
Y
E
Q
S
L
-
44
Fugue
78.55
34%
-102
- C3 -
3MT1
1
?
A:
[2-365]
-----------------
I
E
-
T
P
Y
Y
L
I
D
K
A
K
L
T
R
N
M
E
R
I
A
H
-
V
R
E
K
--------
S
G
A
K
A
L
L
A
L
K
C
F
A
T
W
S
V
F
D
L
M
R
D
--
Y
M---
D
G
T
T
S
S
S
L
F
E
V
R
L
G
R
E
R
F
G
K
--------
E
T
H
A
Y
S
V
A
Y
G
D
N
E
I
D
E
---
V
V
S
H
A
--
D
-
K
-
I
I
F
N
S
I
S
Q
L
E
R
F
A
D
K
A
------------
A
G
I
A
R
G
L
R
L
N
P
----------------
Q
R
L
G
E
W
D
---------------
V
---
P
K
V
-
E
R
V
M
D
R
I
N
G
F
M
----
I
H
N
N
-
N
K
-
D
F
G
L
F
-
D
R
M
L
G
E
I
E
E
R
F
G
A
----
L
----
I
----
A
---
R
V
D
W
V
S
L
G
G
G
I
H
F
T
G
D
--------
D
----
Y
P
-----
V
D
A
------
F
S
A
R
L
R
A
F
S
D
-----
R
------
Y
------
G
V
Q
I
Y
L
E
P
G
E
A
S
I
T
K
S
T
T
L
E
V
T
V
L
D
T
-
L
Y
-
N
-----
G
-------------------------------------------------------------------------------
K
N
L
A
I
V
D
S
S
I
E
A
H
M
L
D
L
L
I
Y
R
-
E
-
T
--
A
-----
K
--
V
-
L
------------------
P
N
E
G
S
---
H
S
Y
M
I
C
G
K
S
C
L
A
G
D
V
F
G
--
E
--------
F
R
F
A
E
E
-
L
---
K
V
G
D
R
I
S
F
Q
D
A
A
G
Y
T
M
V
-
K
K
N
-
W
F
N
G
V
K
M
P
A
I
A
I
R
E
L
--
D
-
G
--
S
-
V
R
T
V
R
E
-
F
T
Y
A
D
Y
E
Q
S
L
S
33
HHSearch
64.47
19%
-84
- C3 -
3VAB
4
?
A:
[44-435]
--------------
A
K
A
V
G
-
T
P
F
Y
V
Y
S
R
A
T
I
E
R
H
-
F
R
V
F
H
D
A
F
A
D
--------
M
D
T
L
V
T
Y
A
L
K
A
N
S
N
Q
A
V
L
T
A
-
L
A
K
L
G
----
A
G
A
D
T
V
S
Q
G
E
I
R
R
A
L
A
A
--
G
I
----
P
A
N
R
I
V
F
S
G
V
G
K
T
P
R
E
M
D
F
---
A
L
E
A
G
--
I
Y
C
-
F
N
V
E
S
E
P
E
L
E
I
L
S
A
R
A
V
A
--------
A
G
K
V
A
P
V
S
L
R
I
N
P
D
V
D
A
K
T
H
A
K
I
---
K
S
E
N
K
F
G
I
P
R
D
K
A
R
--
A
--
A
Y
A
---
R
A
A
S
L
P
G
-
L
N
V
-
V
G
I
D
M
H
-----
I
G
S
Q
-
I
I
D
L
E
P
F
D
-
N
A
-
F
A
L
M
A
E
L
V
K
E
----
L
Q
A
D-
G
----
H
---
N
I
R
H
V
D
V
G
G
G
L
G
I
P
Y
R
--------
T
PP--
P
P
-----
P
V
A
------
Y
A
Q
I
V
A
K
H
I
K
-----
P
------
L
------
G
L
K
T
V
F
E
P
G
R
L
I
V
G
N
A
G
L
L
V
T
E
V
I
F
V
-
K
E
G
D
-----
A
-------------------------------------------------------------------------------
K
N
F
V
I
V
D
A
A
M
N
D
L
-
I
R
P
T
L
Y
D
-
A
F
H
D
I
R
-----
P
--
V
-
I
M
P
---
N
--------------
D
N
A
P
R
I
R
A
D
-
F
V
G
P
V
C
E
T
G
D
Y
L
G
--
L
D-------
R
E
V
A
-
K
-
P
---
A
P
G
D
L
I
A
I
C
T
T
G
A
Y
G
-
A
V
L
S
S
-
T
Y
N
S
R
L
-
L
I
P
E
V
L
G
D
--
G
-
E
--
R
-
Y
H
V
V
R
P
R
R
T
Y
E
E
L
L
A
L
D
-
35
HHSearch
64.23
18%
-82
- C3 -
3N2B
1
DCDA_VIBCH
A:
[47-434]
--------------
A
N
Q
Y
G
-
T
P
L
Y
V
Y
S
R
A
T
L
E
R
H
-
W
H
A
F
D
K
S
V
G
D
--------
Y
P
H
L
I
C
Y
A
V
K
A
N
S
N
L
G
V
L
N
T
-
L
A
R
L
G
----
S
G
F
D
I
V
S
V
G
E
L
E
R
V
L
A
A
--
G
G
----
D
P
S
K
V
V
F
S
G
V
G
K
T
E
A
E
M
K
R
---
A
L
Q
L
K
--
I
K
C
-
F
N
V
E
S
E
P
E
L
Q
R
L
N
K
V
A
G
E
--------
L
G
V
K
A
P
I
S
L
R
I
N
P
D
V
D
A
K
T
H
P
Y
I
S
T
G
L
R
D
N
K
F
G
I
T
F
D
R
A
A
--
Q
--
V
Y
R
---
L
A
H
S
L
P
N
-
L
D
V
-
H
G
I
D
C
H
-----
I
G
S
Q
-
L
T
A
L
A
P
F
I
-
D
A
-
T
D
R
L
L
A
L
I
D
S
----
L
K
A
E
-
G
----
I
---
H
I
R
H
L
D
V
G
G
G
L
G
V
V
Y
--------------
P
Q
-----
P
S
E
------
Y
A
K
A
L
L
D
R
L
E
-----
R
------
H
----
R
-
D
L
E
L
I
F
E
P
G
R
A
I
A
A
N
A
G
V
L
V
T
K
V
E
F
L
-
K
H
T--------------------------------------------------------------------------------------
K
N
F
A
I
I
D
A
A
M
N
D
L
-
I
R
-----------
Q
-----
D
I
-
I
-
P
L
R
---
P
--------------
R
Q
G
E
A
Q
T
Y
D
-
L
V
G
P
V
C
E
T
S
D
F
L
G
--
K
D-------
R
D
L
--
V
-
L
---
Q
E
G
D
L
L
A
V
R
S
S
G
A
Y
G
-
F
T
M
S
S
-
N
Y
N
T
R
P
-
R
V
A
E
V
M
V
D
--
G
-
N
--
K
-
T
Y
L
V
R
Q
R
E
E
L
S
S
L
W
A
L
E
-
25
HHSearch
64.22
18%
-76
- C3 -
1KNW
5
DCDA_ECOLI
A:
[21-416]
--------------
P
A
E
F
G
-
C
P
V
W
V
Y
D
A
Q
I
I
R
R
Q
-
I
A
A
L
K
Q
-
F
D
------------
V
V
R
F
A
Q
K
A
C
S
N
I
H
I
L
R
L
-
M
R
E
Q
G
----
V
K
V
D
S
V
S
L
G
E
I
E
R
A
L
A
A
--
G
Y
N
PQT
H
P
D
D
I
V
F
T
A
D
V
I
D
Q
A
T
L
E
R
---
V
S
E
L
Q
--
I
-
P
-
V
N
A
G
S
V
D
M
L
D
Q
L
G
Q
V
S
------------
P
G
H
R
V
W
L
R
V
N
P
G
F
G
H
G
H
S
Q
K
T
N
T
G
G
E
N
S
K
H
G
I
W
Y
T
D
L
P
--
A
--
A
L
D
---
V
I
Q
-
R
H
H
-
L
Q
L
-
V
G
I
H
M
H
-----
I
G
S
G
-
V
D
-
Y
A
H
L
E
-
Q
V
-
C
G
A
M
V
R
Q
V
I
E
----
F
----
G
----
Q
---
D
L
Q
A
I
S
A
G
G
G
L
S
V
P
Y
Q
--------
Q
GEEA
V
D
-----
T
E
H
Y
Y
G
---
L
W
N
A
A
R
E
Q
I
A
-----
R
H
-----
L
----
G
H
P
V
K
L
E
I
E
P
G
R
F
L
V
A
Q
S
G
V
L
I
T
Q
V
R
S
V
-
K
Q
M
G
-----
S
-------------------------------------------------------------------------------
R
H
F
V
L
V
D
A
G
F
N
D
L
-
M
R
P
A
M
Y
G
-
S
-
Y
--
H
-----
H
--
I
S
A
L
A
---
A
D
G
R
S
---------
L
E
H
A
P
T
V
E
T
V
-
V
A
G
P
L
C
E
S
G
D
V
F
T
--
Q
QEG
G
N
V
E
T
R
A
L
P
-
E
-
V
---
K
A
G
D
Y
L
V
L
H
D
T
G
A
Y
G
-
A
S
M
S
S
-
N
Y
N
S
R
P
-
L
L
P
E
V
L
F
D
--
N
-
G
--
Q
-
A
R
L
I
R
R
R
Q
T
I
E
E
L
L
A
L
E
-
29
HHSearch
62.80
18%
-69
- C3 -
2J66
2
BTRK_BACCI
A:
[12-414]
--------------
T
K
R
F
E
-
T
P
F
Y
L
Y
D
G
D
F
I
E
A
H
-
Y
R
Q
L
R
S
R
T
N
---------
P
A
I
Q
F
Y
L
S
L
K
A
N
N
N
I
H
L
A
K
L
-
F
R
Q
W
G
----
L
G
V
E
V
A
S
A
G
E
L
A
L
A
R
H
A
--
G
F
----
S
A
E
N
I
I
F
S
G
P
G
K
K
R
S
E
L
E
I
---
A
V
Q
S
G
--
I
-
Y
C
I
I
A
E
S
V
E
E
L
F
Y
I
E
E
L
A
E
K
--------
E
N
K
T
A
R
V
A
I
R
I
N
P
D
K
S
F
--
T
A
-
I
K
M
G
G
V
P
R
Q
F
G
M
D
E
S
M
L
D
--
A
--
V
M
D
---
A
V
R
S
L
Q
F
-
T
K
F
-
I
G
I
H
V
Y
-----
T
G
T
Q
-
N
L
N
T
D
S
I
I
-
E
S
-
M
K
Y
T
V
D
L
G
R
N
I
Y
E
R
Y
----
G
----
I
---
V
C
E
C
I
N
L
G
G
G
F
G
V
P
Y
F
EK------
A
----
L
D
-----
I
G
K
------
I
T
R
T
V
S
D
Y
V
Q
E
A
R
D
T
R
------
F
----
P
-
Q
T
T
F
I
I
E
S
G
R
Y
L
L
A
Q
A
A
V
Y
V
T
E
V
L
Y
R
-
K
A
S
K
-----
G
-------------------------------------------------------------------------------
E
V
F
V
I
V
D
G
G
M
H
H
H
-
A
A
S
----------
P
-----
M
E
Y
I
-
P
------------------------
L
E
K
V
T
-
I
A
G
P
L
C
T
P
E
D
C
L
G
--
K
D-------
V
H
V
P
-
A
-
L
---
Y
P
G
D
L
V
C
V
L
N
S
G
A
Y
G
-
L
S
F
S
P
V
H
F
L
G
H
P
-
T
P
I
E
I
L
K
R
--
N
-
G
--
S
-
Y
E
L
I
R
R
K
G
T
A
D
D
I
V
A
T
Q
-
6
PsiBlast_PDB
61.66
19%
-74
- C3 -
2YXX
1
DCDA_THEMA
A:
[13-366]
--------------------
T
P
T
Y
V
Y
F
E
E
T
L
R
K
R
-
S
R
L
V
K
E
V
F
E
G
--------
V
N
L
L
P
T
F
A
V
K
A
N
N
N
P
V
L
L
K
I
-
L
R
E
E
------
G
F
G
M
D
V
V
T
K
G
E
L
L
A
A
K
L
A
G
V
P
---
S
H
T
V
V
W
N
G
N
G
K
S
R
D
Q
M
E
H
F
---
L
R
E
D
V
--
R
-
I
-
V
N
V
D
S
F
E
E
M
E
I
W
R
E
-----------
L
N
P
E
G
V
E
Y
F
I
R
V
N
P
E
V
D
A
K
T
H
P
H
I
S
T
G
L
K
K
H
K
F
G
I
P
L
E
D
L
D
--
S
--
F
M
E
---
R
---
F
R
S
-
M
N
I
-
R
G
L
H
V
H
I
G
SQI
T
R
V
E
-
P
F
-
V
E
A
F
S
-
K
V
-
V
R
A
S
E
R
Y
---------------------
G
F
E
E
I
N
I
G
G
G
W
G
I
N
Y
S
--------
G
----
E
E
-----
L
D
L
S
S
Y
R
E
K
V
V
P
D
L
K
R
F
K
R
----------------------
V
I
V
E
I
G
R
Y
I
V
A
P
S
G
Y
L
L
L
R
V
V
L
V
K
R
R
-
H
-----
N
-------------------------------------------------------------------------------
K
A
F
V
V
V
D
G
G
M
N
V
L
-
I
R
P
A
L
Y
S
-
A
-
Y
--
H
--------
R
-
I
F
V
---
L
G
K
Q
G
K
E
M
R
A
D
V
V
--------------
G
P
L
C
E
S
G
D
V
I
---
A
--------
Y
D
R
E
L
P
E
V
---
E
P
G
D
I
I
A
V
E
N
A
G
A
Y
G
-
Y
T
M
S
N
-
N
Y
N
S
T
T
-
R
P
A
E
V
L
V
R
--
E
-
N
--
G
-
R
I
S
L
I
R
-
R
R
E
T
E
M
D
I
F
K
-
22
HHSearch
61.13
18%
-79
- C3 -
2YXX
1
DCDA_THEMA
A:
[8-382]
--------------
A
E
I
H
G
-
T
P
T
Y
V
Y
F
E
E
T
L
R
K
R
-
S
R
L
V
K
E
V
F
E
G
--------
V
N
L
L
P
T
F
A
V
K
A
N
N
N
P
V
L
L
K
I
-
L
R
E
E
G
----
F
G
M
D
V
V
T
K
G
E
L
L
A
A
K
L
A
--
G
V
----
P
S
H
T
V
V
W
N
G
N
G
K
S
R
D
Q
M
E
H
---
F
L
R
E
D
--
V
-
R
I
V
N
V
D
S
F
E
E
M
E
I
W
R
E
L
N
P
-----------
E
G
V
E
Y
F
I
R
V
N
P
E
V
D
A
K
T
H
P
H
I
S
T
G
L
K
K
H
K
F
G
I
P
L
E
D
L
D
--
S
--
F
M
E
---
R
---
F
R
S
-
M
N
I
-
R
G
L
H
V
H
-----
I
G
S
Q
-
I
T
R
V
E
P
F
V
-
E
A
-
F
S
K
V
V
R
A
S
E
R
----
Y
-------------
G
F
E
E
I
N
I
G
G
G
W
G
I
N
Y
S
G
E
------
E
----
L
D
-----
L
S
S
------
Y
R
E
K
V
V
P
D
L
K
-----
R
-------------
F
K
R
V
I
V
E
I
G
R
Y
I
V
A
P
S
G
Y
L
L
L
R
V
V
L
V
-
K
R
R
H
-----
N
-------------------------------------------------------------------------------
K
A
F
V
V
V
D
G
G
M
N
V
L
-
I
R
P
A
L
Y
S
-
A
-
Y
--
H
-----
R
--
I
-
F
V
L
---
G
--------------
K
Q
G
K
E
M
R
A
D
-
V
V
G
P
L
C
E
S
G
D
V
I
A
--
Y
D-------
R
E
L
P
-
E
-
V
---
E
P
G
D
I
I
A
V
E
N
A
G
A
Y
G
-
Y
T
M
S
N
-
N
Y
N
S
T
T
-
R
P
A
E
V
L
V
R
--
E
N
G
--
R
-
I
S
L
I
R
R
R
E
T
E
M
D
I
F
K
D
V
-
36
HHSearch
61.04
18%
-88
- C3 -
2P3E
-
DCDA_AQUAE
A:
[29-415]
--------------
A
Q
T
F
G
-
T
P
L
Y
V
Y
S
S
N
F
I
K
E
R
-
F
E
A
Y
R
K
A
F
P
----------
D
A
L
I
C
Y
A
V
K
A
N
F
N
P
H
L
V
K
L
-
L
G
E
L
G
----
A
G
A
D
I
V
S
G
G
E
L
Y
L
A
K
K
A
--
G
I
----
P
P
E
R
I
V
Y
A
G
V
G
K
T
E
K
E
L
T
D
---
A
V
D
S
E
--
I
L
M
-
F
N
V
E
S
R
Q
E
L
D
V
L
N
E
I
A
G
K
--------
L
G
K
K
A
R
I
A
I
R
V
N
P
----------------
S
K
F
G
V
D
I
R
E
A
Q
--
K
--
E
Y
E
Y
A
S
K
---
L
E
N
-
L
E
I
-
V
G
I
H
C
H
-----
I
G
S
Q
-
I
L
D
I
S
P
Y
R
-
E
A
-
V
E
K
V
V
S
L
Y
E
S
----
L
T
Q
K
-
G
----
F
---
D
I
K
Y
L
D
I
G
G
G
L
G
I
K
Y
K
--------
P
E
D
K
E
P
A
-----
P
Q
D
------
L
A
D
L
L
K
D
L
L
-------------
V
------
K
A
K
I
I
L
E
P
G
R
S
I
M
G
N
A
G
I
L
I
T
Q
V
Q
F
L
-
K
D
K
G
-----
S
-------------------------------------------------------------------------------
K
H
F
I
I
V
D
A
G
M
N
D
L
-
I
R
P
S
I
Y
N
-
A
-
Y
--
H
-----
H
--
I
-
I
-
P
---
V
E
T
------------
K
E
---
V
V
A
D
-
I
V
G
P
I
C
E
T
G
D
F
L
A
--
L
D-------
R
E
I
E
-
E
-
V
---
Q
R
G
E
Y
L
A
V
L
S
A
G
A
Y
G
-
F
A
M
S
S
-
H
Y
N
M
R
P
-
R
A
A
E
V
L
V
E
--
N
-
G
--
S
-
V
K
L
I
R
K
R
E
N
Y
D
Y
I
V
E
P
S
-
37
HHSearch
60.35
16%
-87
- C3 -
2PLJ
3
?
A:
[50-410]
--------------
V
E
Q
F
G
-
A
P
L
L
L
L
D
C
D
V
I
R
Q
Q
-
Y
R
A
L
K
N
A
L
P
----------
N
V
T
L
H
Y
A
L
K
P
L
P
H
P
V
V
V
R
T
-
L
L
A
E
G
----
A
S
F
D
L
A
T
T
G
E
V
E
L
V
A
S
E
--
G
V
----
P
A
D
L
T
I
H
T
H
P
I
K
R
D
A
D
I
R
D
---
A
L
A
Y
G
--
C
-
N
V
F
V
V
D
N
L
N
E
L
E
K
F
K
A
Y
R
------------
D
D
V
E
L
L
V
R
L
S
F
---------------
S
K
K
F
G
C
S
P
E
Q
A
L
--
V
--
I
I
E
---
T
A
K
-
E
W
N
-
I
R
I
-
K
G
L
S
F
H
-----
V
G
S
Q
-
T
T
N
P
N
K
Y
V
-
E
A
-
I
H
T
C
R
H
V
M
E
Q
----
V
V
E
R
G
L
----
P
---
A
L
S
T
L
D
I
G
G
G
F
P
V
N
Y
T
QQ------
V
----
M
P
-----
I
D
Q
------
F
C
A
P
I
N
E
A
L
S
-----
L
------
L
----
P
E
T
V
H
V
L
A
E
P
G
R
F
I
C
A
P
A
V
T
S
V
A
S
V
M
G
Q
-
A
E
R
E
-----
G
-------------------------------------------------------------------------------
Q
I
W
Y
Y
L
D
D
G
I
Y
G
S
-
F
S
G
L
M
F
D
D
A
-
R
--
Y
-----
P
--
L
-
T
T
I
---
K
--------------
Q
G
G
E
L
I
P
S
V
-
L
S
G
P
T
C
D
S
V
D
V
I
A
--
E
N
-------
I
L
L
P
-
K
-
L
---
N
N
G
D
L
V
I
G
R
T
M
G
A
Y
T
-
S
A
T
A
T
-
D
F
N
F
F
K
-
R
A
Q
T
I
A
L
N
--
E
-
F
--
V
-------------------
31
HHSearch
59.54
17%
-81
* C3 *
2QGH
2
DCDA_HELPX
A:
[28-417]
--------------
F
Q
T
H
K
-
T
P
F
Y
L
Y
D
F
D
K
I
K
Q
A
-
F
L
N
Y
K
E
A
F
K
G
--------
R
K
S
L
I
C
Y
A
L
K
A
N
S
N
L
S
I
L
S
L
-
L
A
H
L
E
----
S
G
A
D
C
V
S
I
G
E
I
Q
R
A
L
K
A
--
G
I
----
K
P
Y
R
I
V
F
S
G
V
G
K
S
A
F
E
I
E
Q
---
A
L
K
L
N
--
I
-
L
F
L
N
V
E
S
F
M
E
L
K
T
I
E
T
I
A
Q
S
--------
L
G
I
K
A
R
I
S
I
R
I
N
P
N
I
D
A
K
T
H
P
Y
I
S
T
G
L
K
E
N
K
F
G
V
G
E
K
E
A
L
--
E
--
M
F
L
W
A
K
K
---
S
A
F
-
L
E
P
-
V
S
V
H
F
H
-----
I
G
S
Q
-
L
L
D
L
E
P
I
I
-
E
A
-
S
Q
K
V
A
K
I
A
K
S
L
I
A
-
L
----
G
----
I
---
D
L
R
F
F
D
V
G
G
G
I
G
V
S
Y
E
--------
N
EET-
I
K
-----
L
Y
D
------
Y
A
Q
G
I
L
N
A
L
Q
-----
G
------
L
------
D
L
T
I
I
C
E
P
G
R
S
I
V
A
E
S
G
E
L
I
T
Q
V
L
Y
E
-
K
K
-------
N
-------------------------------------------------------------------------------
K
R
F
V
I
V
D
A
G
M
N
D
F
-
L
R
P
S
L
Y
H
A
K
-
H
--
A
-----
I
--
R
-
V
I
T
---
P
S
----------------
E
I
S
P
C
D
-
V
V
G
P
V
C
E
S
S
D
T
F
L
--
K
D-------
A
H
L
P
-
E
-
L
---
E
P
G
D
K
I
A
I
E
K
V
G
A
Y
G
-
S
S
M
A
S
-
Q
Y
N
S
R
P
-
K
L
L
E
L
A
L
E
--
D
----
K
-
I
R
V
I
R
K
R
E
A
L
E
D
L
W
R
L
E
-
40
HHSearch
58.92
17%
-82
- C3 -
3NZP
3
?
A:
[41-562]
---------------
D
G
Y
K
-
G
P
L
L
L
R
F
P
H
L
I
Q
K
Q
-
I
E
N
I
Y
G
N
F
N
K
A
R
K
E
F
GYK
G
G
F
N
A
V
Y
P
L
K
V
N
Q
Y
P
G
F
V
K
N
-
L
V
K
L
G
K
DYN
Y
G
L
E
A
G
S
K
A
E
L
L
L
A
M
A
Y
--
N
N
----
E
G
A
P
I
T
V
N
G
F
-
K
D
R
E
L
I
N
I
G
F
I
A
A
E
M
G
HN
I
-
T
-
L
T
I
E
G
L
N
E
L
E
A
I
I
D
I
A
K
E
R
-------
F
K
P
K
P
N
I
G
L
R
V
R
L
H
S
A
--------------
K
F
G
L
T
S
T
E
L
I
--
E
--
A
V
N
---
L
L
K
E
N
K
L
L
E
Q
F
-
T
M
I
H
F
H
-----
L
G
S
Q
-
I
T
E
I
H
P
L
K
-
K
A
-
L
N
E
A
G
N
I
Y
T
E
----
L
R
K
M
-
G
----
A
K--
N
L
K
A
I
N
L
G
G
G
L
A
V
E
Y
S
QFKNEKSR
N
----
Y
T
-----
L
R
E
------
Y
A
N
D
V
V
F
I
L
K
-----
N
I
A
E
Q
K
K
D
----
L
-
E
P
D
I
F
I
E
S
G
R
F
V
A
A
N
H
A
V
L
I
A
P
V
L
E
L
-
F
S
Q
E
-----
Y
AENKLILKKQNP
K
L
I
D
E
L
Y
D
L
Y
K
S
IKPSN
A
L
E
Y
L
H
D
S
I
D
H
L
E
S
I
L
T
L
F
D
L
GYVD
L
Q
D
R
S
N
A
E
I
L
T
H
L
I
T
K
K
A
I
L
L
LGEV
Q
E
R
Y
L
V
N
F
S
L
F
Q
S
-
M
P
D
F
W
G
L
-
E
-
Q
N-
F
-----
P
--
I
-
M
-
P
---
L
D
R
L
-----------
D
E
E
P
T
R
S
A
S
-
I
W
D
I
T
C
D
S
D
G
E
I
S
YS
K
D
K
P
-----
L
F
L
H
-
D
-
V
DVE
K
E
N
Y
F
L
G
F
F
L
V
G
A
Y
Q
-
E
V
L
G
M
-
K
H
N
L
F
T
-
H
P
T
E
A
I
I
S
I
N
E
-
K
G
Y
E
-
V
E
G
I
I
E
A
Q
S
I
L
D
T
L
E
D
L
-
26
HHSearch
58.09
18%
-73
- C3 -
1TWI
3
DCDA_METJA
A:
[25-426]
--------------
A
E
K
F
G
-
T
P
L
Y
V
M
S
E
E
Q
I
K
I
N
-
Y
N
R
Y
I
E
A
F
K
R
W
E
E
E
TG--
K
E
F
I
V
A
Y
A
Y
K
A
N
A
N
L
A
I
T
R
L
-
L
A
K
L
G
----
C
G
A
D
V
V
S
G
G
E
L
Y
I
A
K
L
S
--
N
V
----
P
S
K
K
I
V
F
N
G
N
C
K
T
K
E
E
I
I
M
---
G
I
E
A
N
--
I
R
A
-
F
N
V
D
S
I
S
E
L
I
L
I
N
E
T
A
K
E
--------
L
G
E
T
A
N
V
A
F
R
I
N
P
N
V
N
P
K
T
H
P
K
I
S
T
G
L
K
K
N
K
F
G
L
D
V
E
S
G
I
--
A
M
K
A
I
K
M
A
L
E
---
M
E
Y
-
V
N
V
-
V
G
V
H
C
H
-----
I
G
S
Q
-
L
T
D
I
S
P
F
I
-
E
E
-
T
R
K
V
M
D
F
V
V
E
L
K
E
-
E
----
G
----
I
---
E
I
E
D
V
N
L
G
G
G
L
G
I
P
Y
Y
KDKQ----
I
----
P
T
-----
Q
K
D
------
L
A
D
A
I
I
N
T
M
L
-----
K
------
Y
KDKV
E
-
M
P
N
L
I
L
E
P
G
R
S
L
V
A
T
A
G
Y
L
L
G
K
V
H
H
I
-
K
E
T
P
-----
V
-------------------------------------------------------------------------------
T
K
W
V
M
I
D
A
G
M
N
D
M
-
M
R
P
A
M
Y
E
-
A
-
Y
--
H
-----
H
--
I
-
I
N
C
---
K
--------------
V
K
N
E
K
E
V
V
S
-
I
A
G
G
L
C
E
S
S
D
V
F
G
--
R
D-------
R
E
L
D
-
K
-
V
---
E
V
G
D
V
L
A
I
F
D
V
G
A
Y
G
-
I
S
M
A
N
-
N
Y
N
A
R
G
-
R
P
R
M
V
L
T
S
--
K
-
K
--
G
-
V
F
L
I
R
E
R
E
T
Y
A
D
L
I
A
K
D
-
48
Fugue
55.72
15%
-80
- C3 -
1F3T
4
DCOR_TRYBB
A:
[14-422]
RFLEGFN
T
R
D
A
L
C
K
K
I
S
-
G
-
D
P
F
F
V
A
D
L
G
D
I
V
R
K
-
H
E
T
W
K
K
C
--
L
--------
P
R
V
T
P
F
Y
A
V
K
C
N
D
D
W
R
V
L
G
T
-
L
A
A
L
G
----
T
G
F
D
C
A
S
N
T
E
I
Q
R
V
R
G
---
I
G
V
---
P
P
E
K
I
I
Y
A
N
P
C
K
Q
I
S
H
I
R
Y
---
A
R
D
----------------------------
S
G
V
D
V
M
T
F
D
C
V
D
E
L
E
K
V
A
K
T
H
P
K
A
K
M
V
L
R
I
S
T
V
K
F
G
A
K
V
E
D
C
R
F
I
L
--
E
--
Q
A
K
---
K
---
L
N
I
--
D
V
-
T
G
V
S
F
H
-----
V
G
S
G
S
T
D
-
A
S
T
F
A
-
Q
A
-
I
S
D
S
R
F
V
F
D
M
----
G
----
T
----
E
L
GF
N
M
H
I
L
D
I
G
G
G
F
P
G
T
R
D
--------
A
----
P
L
K
F
E
E
I
A
G
V
------
I
N
N
A
L
E
K
H
F
P
-----
P
------
D
----
L
-
K
L
T
I
V
A
E
P
G
R
Y
Y
V
A
S
A
F
T
L
A
V
N
V
I
A
K
-
K
V
T------
Q
-------------------------------------------------------------------------------
S
F
M
Y
Y
V
N
D
G
V
Y
G
S
-
F
N
C
I
L
Y
D
-
H
-
A
--
V
-----
V
--
R
-
P
-------------
L
P
Q
R
E
P
I
P
N
E
K
L
Y
P
S
S
-
V
W
G
P
T
C
D
G
L
D
Q
I
V
--
E
--------
R
Y
Y
L
P
E
-
M
---
Q
V
G
E
W
L
L
F
E
D
M
G
A
Y
T
-
V
V
G
T
S
-
S
F
N
G
F
Q
-
S
P
T
I
Y
Y
V
V
--
S
-
G
--
L
-
P
D
H
V
V
R
-
E
L
K
S
-------
27
HHSearch
55.52
17%
-84
- C3 -
2NVA
2
?
A:
[12-372]
---------------
H
P
H
Q
T
K
S
F
Y
V
S
S
P
K
I
V
E
D
L
-
I
D
Q
W
T
I
L
F
P
----------
R
V
T
P
H
Y
A
V
K
C
N
N
D
E
V
L
L
K
T
-
M
C
D
K
N
----
V
N
F
D
C
A
S
S
S
E
I
K
K
V
I
Q
I
--
G
V
----
S
P
S
R
I
I
F
A
H
T
M
K
T
I
D
D
L
I
F
---
A
K
D
Q
G
--
V
-
D
I
A
T
F
D
S
S
F
E
L
D
K
I
H
T
Y
H
------------
P
N
C
K
M
I
L
R
I
R
C
D
D
P
N
------
A
T
V
Q
L
G
N
K
F
G
A
N
E
D
E
I
R
--
H
--
L
L
E
---
Y
A
K
-
Q
L
D
-
I
E
V
-
I
G
I
S
F
H
-----
V
G
S
G
-
S
R
N
P
E
A
Y
Y
-
R
A
-
I
K
S
S
K
E
A
F
N
E
----
A
I
S
V
-
G
----
H
---
K
P
Y
I
L
D
I
G
G
G
L
H
A
D
I
D
---------------L----
S
T
Y
------
M
S
D
Y
I
N
D
A
I
K
-----
D
F-----
F
PE--
D
-
T
V
T
I
V
A
E
P
G
R
F
F
A
E
H
Y
S
V
L
A
T
Q
V
I
G
K
-
R
V
R
D
-----
G
-------------------------------------------------------------------------------
L
Y
E
Y
F
F
N
E
S
T
Y
G
G
-
F
S
N
V
I
F
E
-
K
-
S
V
P
T
-----
P
--
Q
-
L
L
R
---
D
V
------------
P
D
D
E
E
Y
V
P
S
V
-
L
Y
G
C
T
C
D
G
V
D
V
I
N
--
H
N
-------
V
A
L
P
-
E
-
L
---
H
I
G
D
W
V
Y
F
P
S
W
G
A
Y
T
-
N
V
L
T
T
-
S
F
N
G
F
G
-
E
Y
D
V
Y
Y
I
----------------------------
23
HHSearch
54.16
14%
-71
- C3 -
2O0T
1
DCDA_MYCTU
A:
[37-446]
--------------
A
Q
E
Y
G
-
T
P
L
F
V
I
D
E
D
D
F
R
S
R
-
C
R
E
T
A
A
A
F
G
---------
S
G
A
N
V
H
Y
A
A
K
A
F
L
C
S
E
V
A
R
W
-
I
S
E
E
G
----
L
C
L
D
V
C
T
G
G
E
L
A
V
A
L
H
A
--
S
F
----
P
P
E
R
I
T
L
H
G
N
N
K
S
V
S
E
L
T
A
---
A
V
K
A
G
--
V
G
H
-
I
V
V
D
S
M
T
E
I
E
R
L
D
A
I
A
G
E
--------
A
G
I
V
Q
D
V
L
V
R
L
T
V
G
V
E
A
H
T
H
E
F
I
S
T
A
H
E
D
Q
K
F
G
L
S
V
A
S
G
A
A
M
A
--
A
V
R
R
V
F
A
---
T
D
H
-
L
R
L
-
V
G
L
H
S
H
-----
I
G
S
Q
-
I
F
D
V
D
G
F
E
-
L
A
-
A
H
R
V
I
G
L
L
R
D
----
V
V
G
E
F
G
PEKT
A
---
Q
I
A
T
V
D
L
G
G
G
L
G
I
S
Y
L
P
S
D
D
----
P
----
P
P
-----
I
A
E
------
L
A
A
K
L
G
T
I
V
S
-----
D
E
S
T
A
VG
L
----
P
-
T
P
K
L
V
V
E
P
G
R
A
I
A
G
P
G
T
I
T
L
Y
E
V
G
T
V
-
K
D
V
D
VSA
T
A
H
-------------------------------------------------------------------------------
R
R
Y
V
S
V
D
G
G
M
S
D
N
-
I
R
T
A
L
Y
G
-
A
Q
Y
--
D
-----
V
--
R
-
L
V
S
---
R
V
-------------
S
D
A
P
P
V
P
A
R
-
L
V
G
K
H
C
E
S
G
D
I
I
V
--
R
D
-------
T
W
V
P
D
D
-
I
---
R
P
G
D
L
V
A
V
A
A
T
G
A
Y
C
-
Y
S
L
S
S
-
R
Y
N
M
V
G
-
R
P
A
V
V
A
V
H
--
A
-
G
--
N
-
A
R
L
V
L
R
R
E
T
V
D
D
L
L
S
L
E
-