@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0039: (2015-12-12 )
MNEIILITGAYGMVGQNTALYFKKNKPDVTLLTPKKSELYLLDKDNVQAYLKEYKPTGIIHCAGRVGGIVANMNDLSTYMVENLLMGLYLFSSALDLGVKKAINLASSCAYPKYAPNPLKESDLLNGSLEPTNEGYALAKLSVMKYCEYVSAEKGVFYKTLVPCNLYGEFDKFEEKIAHMIPGLIARMHTAKLKNEKNFAMWGDGTARREYLNAKDLARFIALAYENIAQMPSVMNVGSGVDYSIEEYYEKVAQVLDYKGVFVKDSSKPVGMQQKLMDISKQKALKWELEIPLEQGIKEAYEYYLKLLEV
Atome Classification :
(20 SA)
.........10........20.....----...---30-...--------------------------...-------------..40........50........60........70........80........90......---------..100.......110....-----.----------..120.......130........140.......150.......160......-.170.......180.......190.......200.......210......----.-220...----...-.--------230.......240.......250.......260-------.-.-.----.....270.......280.-.-.....290........300.......310
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MN
E
I
I
L
I
TGAYGMVGQ
N
T
A
L
Y
F
KKNK----P
D
V
---
T
L
-LTP--------------------------KKS-------------
E
L
Y
L
LD
K
D
N
V
Q
A
Y
L
K
EYKPT
G
I
I
H
CAGRV
G
G
I
VA
N
M
N
D
L
S
T
Y
M
V
E
N
L
L
M
G
L
Y
L
F
S
S
A
L
D
L
---------
G
V
K
K
A
I
N
L
A
S
SCAYPKYAP-----N----------PL
K
E
S
DLLNGSLEP-TNEGY
A
L
A
K
L
S
V
M
K
Y
C
E
Y
VSAEKG
V
F
Y
K
T
LVPCNLYG-
E
F
D
K
F
E
E
K
I
A
H
M
I
P
G
L
I
A
R
M
H
T
A
KLKNEKN
F
A
MWGDG
T
A
R
R
EYL
N
A
K
D
L
A
----
R
-
F
I
A
L
A
Y
----
E
N
I
-
A
--------QM
P
S
V
MNVGSGVDY
S
I
E
E
Y
Y
E
K
V
A
Q
V
LDYK
G
V
--------
F
-
V
-K----DSSKPV
G
M
Q
Q
K
L
M
D
I
S
KQK-
A
-
L
K
W
E
L
EI-
P
L
E
Q
G
I
K
E
A
Y
E
Y
Y
L
K
L
LEV
2
PsiBlast_PDB
92.21
37%
-91
- C1 -
1FXS
1
FCL_ECOLI
A:
[6-314]
----
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
E
Q
-
R
----
G
D
V
---
E
L
-
V
L
R
--------------------------
T
R
D
-------------
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
---------
D
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
-----
Q
----------
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
-
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
-
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
N
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
-
V
M
E
L
A
H
E
V
W
L
E
N
T
-
Q
--------
P
M
L
S
H
I
N
V
G
T
G
V
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
--------
V
-
V
-
F
----
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
H
-
Q
-
L
G
W
Y
H
E
I
-
S
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
D
R
6
PsiBlast_PDB
91.86
37%
-89
- C1 -
1E7S
6
FCL_ECOLI
A:
[6-314]
----
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
E
Q
-
R
----
G
D
V
---
E
L
-
V
L
R
--------------------------
T
R
D
-------------
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
---------
D
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
-----
Q
----------
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
-
T
N
E
P
Y
A
I
A
R
I
A
G
I
K
L
C
E
S
Y
N
R
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
-
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
S
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
-
V
M
E
L
A
H
E
V
W
L
E
N
T
-
Q
--------
P
M
L
S
H
I
N
V
G
T
G
V
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
--------
V
-
V
-
F
----
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
H
-
Q
-
L
G
W
Y
H
E
I
-
S
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
--
7
PsiBlast_PDB
91.31
37%
-89
- C1 -
1E7Q
7
FCL_ECOLI
A:
[6-314]
----
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
E
Q
-
R
----
G
D
V
---
E
L
-
V
L
R
--------------------------
T
R
D
-------------
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
---------
D
V
N
K
L
L
F
L
G
A
S
C
I
Y
P
K
L
A
K
-----
Q
----------
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
-
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
-
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
S
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
-
V
M
E
L
A
H
E
V
W
L
E
N
T
-
Q
--------
P
M
L
S
H
I
N
V
G
T
G
V
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
--------
V
-
V
-
F
----
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
H
-
Q
-
L
G
W
Y
H
E
I
-
S
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
--
4
PsiBlast_PDB
91.05
37%
-89
- C1 -
1BWS
1
FCL_ECOLI
A:
[6-314]
----
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
E
Q
-
R
----
G
D
V
---
E
L
-
V
L
R
--------------------------
T
R
D
-------------
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
---------
D
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
-----
Q
----------
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
-
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
-
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
N
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
-
V
M
E
L
A
H
E
V
W
L
E
N
T
-
Q
--------
P
M
L
S
H
I
N
V
G
T
G
V
D
C
T
I
R
D
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
--------
V
-
V
-
F
----
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
H
-
Q
-
L
G
W
Y
H
E
I
-
S
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
--
3
PsiBlast_PDB
91.04
37%
-93
- C1 -
1GFS
-
FCL_ECOLI
A:
[6-314]
----
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
E
Q
-
R
----
G
D
V
---
E
L
-
V
L
R
--------------------------
T
R
D
-------------
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
---------
D
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
-----
Q
----------
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
-
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
-
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
N
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
-
V
M
E
L
A
H
E
V
W
L
E
N
T
-
Q
--------
P
M
L
S
H
I
N
V
G
T
G
V
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
--------
V
-
V
-
F
----
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
H
-
Q
-
L
G
W
Y
H
E
I
-
S
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
D
R
1
PsiBlast_PDB
90.69
37%
-92
- C1 -
1BSV
1
FCL_ECOLI
A:
[6-314]
----
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
E
Q
-
R
----
G
D
V
---
E
L
-
V
L
R
--------------------------
T
R
D
-------------
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
---------
D
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
-----
Q
----------
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
-
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
-
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
N
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
-
V
M
E
L
A
H
E
V
W
L
E
N
T
-
Q
--------
P
M
L
S
H
I
N
V
G
T
G
V
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
--------
V
-
V
-
F
----
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
H
-
Q
-
L
G
W
Y
H
E
I
-
S
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
D
R
5
PsiBlast_PDB
90.59
37%
-89
- C1 -
1E6U
7
FCL_ECOLI
A:
[6-314]
----
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
E
Q
-
R
----
G
D
V
---
E
L
-
V
L
R
--------------------------
T
R
D
-------------
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
---------
D
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
-----
Q
----------
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
-
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
-
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
K
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
-
V
M
E
L
A
H
E
V
W
L
E
N
T
-
Q
--------
P
M
L
S
H
I
N
V
G
T
G
V
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
--------
V
-
V
-
F
----
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
H
-
Q
-
L
G
W
Y
H
E
I
-
S
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
--
8
PsiBlast_PDB
90.52
37%
-87
- C1 -
1E7R
6
FCL_ECOLI
A:
[6-314]
----
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
E
Q
-
R
----
G
D
V
---
E
L
-
V
L
R
--------------------------
T
R
D
-------------
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
---------
D
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
-----
Q
----------
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
-
T
N
E
P
E
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
-
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
S
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
-
V
M
E
L
A
H
E
V
W
L
E
N
T
-
Q
--------
P
M
L
S
H
I
N
V
G
T
G
V
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
--------
V
-
V
-
F
----
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
H
-
Q
-
L
G
W
Y
H
E
I
-
S
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
--
34
HHSearch
88.97
35%
-91
- C1 -
1E6U
7
FCL_ECOLI
A:
[2-316]
A
K
Q
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
E
Q
R
-------
G
D--
V
E
L
V
L
R
--------------------------
T
R
D
-------------
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
---------
D
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
-----
Q
----------
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
T
N
E
-
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
-
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
K
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
----
A
-
A
S
I
H
V
M
----
E
L
A
-
H
E
V
W
L
E
N
T
Q
P
M
L
S
H
I
N
V
G
T
G
V
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
--------
V
-
V
-
F
----
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
H
-
Q
-
L
G
W
Y
H
E
I
-
S
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
--
15
PsiBlast_PDB
78.21
24%
-83
- C1 -
4ZRN
2
?
A:
[6-312]
----
I
L
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
I
E
N
G
----
Y
G
V
---
I
V
-
V
D
N
--------------------------
L
S
S
GKVENLNRN
A
L
F
Y
E
Q
S
I
E
D
E
E
M
M
E
R
I
F
S
L
H
R
P
E
Y
V
F
H
L
A
A
Q
-
A
S
V
A
I
S
V
R
E
P
A
R
D
A
K
T
N
I
I
G
S
L
V
L
L
E
K
S
I
K
Y
---------
G
V
K
K
F
I
--
F
S
S
T
G
G
A
I
Y
G
E
-----
N
VKVF------
P
T
P
E
T
E
I
P
H
-
P
I
S
P
-----
Y
G
I
A
K
Y
S
T
E
M
Y
L
E
F
F
A
R
E
Y
G
L
K
Y
T
V
L
R
Y
A
N
V
Y
G
P
R
Q
D
P
Y
G
E
A
------
G
V
V
A
-
I
F
T
E
R
M
L
R
G
E
E
V
H
I
F
G
D
G
E
Y
V
R
D
Y
V
Y
V
D
D
V
V
----
R
-
A
N
L
L
A
M
----
E
K
G
-
D
--------
N
--
E
V
F
N
I
G
T
G
R
G
T
T
V
N
Q
L
F
K
L
L
K
E
I
T
G
Y
D
K
E
--------
P
-
V
-
Y
----
K
P
P
R
K
G
D
V
R
K
S
I
L
D
Y
T
K
A
K
-
E
K
L
G
W
E
P
K
V
-
S
L
E
E
G
L
K
L
T
V
E
Y
F
R
K
T
L
E
-
9
PsiBlast_PDB
77.92
27%
-80
- C1 -
4B8W
2
FCL_HUMAN
A:
[9-311]
----
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
GLPG
E
D
W
---
V
F
-
V
S
S
--------------------------
K
D
A
-------------
D
L
--
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
---------
G
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
-----
Y
----------
P
I
D
E
T
M
I
H
N
G
P
P
H
N
-
S
N
F
G
Y
S
Y
A
K
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
-
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
S
A
-
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
----
Q
L
F
I
W
V
L
R
----
E
Y
N
-
E
--------
V
E
P
I
I
L
S
V
G
E
E
D
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
--------
V
-
T
-
F
----
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
L
R
-
T
-
Y
L
P
D
F
R
F
T
P
F
K
Q
A
V
K
E
T
C
A
W
F
T
D
N
Y
E
Q
14
PsiBlast_PDB
76.40
24%
-82
- C1 -
4ZRM
3
?
A:
[6-311]
----
I
L
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
I
E
N
G
----
Y
G
V
---
I
V
-
V
D
N
--------------------------
L
S
S
GKVENLNRN
A
L
F
Y
E
Q
S
I
E
D
E
E
M
M
E
R
I
F
S
L
H
R
P
E
Y
V
F
H
L
A
A
Q
-
A
S
V
A
I
S
V
R
E
P
A
R
D
A
K
T
N
I
I
G
S
L
V
L
L
E
K
S
I
K
Y
---------
G
V
K
K
F
I
--
F
S
S
T
G
G
A
I
Y
G
E
-----
N
VKVF------
P
T
P
E
T
E
I
P
H
-
P
I
S
P
-----
Y
G
I
A
K
Y
S
T
E
M
Y
L
E
F
F
A
R
E
Y
G
L
K
Y
T
V
L
R
Y
A
N
V
Y
G
P
R
Q
D
P
Y
G
E
A
------
G
V
V
A
-
I
F
T
E
R
M
L
R
G
E
E
V
H
I
F
G
D
G
E
Y
V
R
D
Y
V
Y
V
D
D
V
V
----
R
-
A
N
L
L
A
M
----
E
K
G
-
D
--------
N
--
E
V
F
N
I
G
T
G
R
G
T
T
V
N
Q
L
F
K
L
L
K
E
I
T
G
Y
D
K
E
--------
P
-
V
-
Y
----
K
P
P
R
K
G
D
V
R
K
S
I
L
D
Y
T
K
A
K
-
E
K
L
G
W
E
P
K
V
-
S
L
E
E
G
L
K
L
T
V
E
Y
F
R
K
T
L
--
12
PsiBlast_PDB
76.24
27%
-81
- C1 -
4BL5
2
FCL_HUMAN
A:
[25-327]
----
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
GLPG
E
D
W
---
V
F
-
V
S
S
--------------------------
K
D
A
-------------
D
L
--
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
---------
G
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
-----
Y
----------
P
I
D
E
T
M
I
H
N
G
P
P
H
N
-
S
N
F
G
Y
S
Y
A
K
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
-
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
S
A
-
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
----
Q
L
F
I
W
V
L
R
----
E
Y
N
-
E
--------
V
E
P
I
I
L
S
V
G
E
E
D
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
--------
V
-
T
-
F
----
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
L
R
-
T
-
Y
L
P
D
F
R
F
T
P
F
K
Q
A
V
K
E
T
C
A
W
F
T
D
N
Y
E
Q
10
PsiBlast_PDB
75.86
27%
-80
- C1 -
4B8Z
2
FCL_HUMAN
A:
[10-312]
----
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
GLPG
E
D
W
---
V
F
-
V
S
S
--------------------------
K
D
A
-------------
D
L
--
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
---------
G
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
-----
Y
----------
P
I
D
E
T
M
I
H
N
G
P
P
H
N
-
S
N
F
G
Y
S
Y
A
K
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
-
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
S
A
-
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
----
Q
L
F
I
W
V
L
R
----
E
Y
N
-
E
--------
V
E
P
I
I
L
S
V
G
E
E
D
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
--------
V
-
T
-
F
----
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
L
R
-
T
-
Y
L
P
D
F
R
F
T
P
F
K
Q
A
V
K
E
T
C
A
W
F
T
D
N
---
11
PsiBlast_PDB
75.36
27%
-77
- C1 -
4BKP
2
FCL_HUMAN
A:
[25-327]
----
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
GLPG
E
D
W
---
V
F
-
V
S
S
--------------------------
K
D
A
-------------
D
L
--
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
---------
G
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
-----
Y
----------
P
I
D
E
T
M
I
H
N
G
P
P
H
N
-
S
N
F
G
Y
S
Y
A
K
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
-
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
S
A
-
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
----
Q
L
F
I
W
V
L
R
----
E
Y
N
-
E
--------
V
E
P
I
I
L
S
V
G
E
E
D
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
--------
V
-
T
-
F
----
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
L
R
-
T
-
Y
L
P
D
F
R
F
T
P
F
K
Q
A
V
K
E
T
C
A
W
F
T
D
N
Y
E
Q
49
HHSearch
74.18
22%
-80
- C1 -
2C5A
13
GME_ARATH
A:
[28-342]
E
N
L
K
I
S
I
T
G
A
G
G
F
I
A
S
H
I
A
R
R
L
K
H
E
-------
G
H
--
Y
V
-
I
A
S
D
WKKNEHMTEDMFCD-----------
E
F
H
-------------
L
V
D
L
R
V
M
E
N
C
L
K
V
T
E
--
G
V
D
H
V
F
N
L
A
A
D
M
G
G
M
G
F
I
Q
S
N
H
S
V
I
M
Y
N
N
T
M
I
S
F
N
M
I
E
A
A
R
I
N
---------
G
I
K
R
F
F
Y
A
S
S
A
C
I
Y
P
E
F
K
Q
LETTN
V
----------
S
L
K
E
S
D
A
W
--
P
A
E
P
-
Q
D
-
A
F
G
L
E
K
L
A
T
E
E
L
C
K
H
Y
N
K
D
F
G
I
E
C
R
I
G
R
F
H
N
I
Y
G
-
P
F
G
T
W
K
G
G
R
E
K
A
P
A
A
F
C
R
K
A
---
Q
T
S
-
T
D
R
F
E
M
W
G
D
G
L
Q
T
R
S
F
T
F
I
D
E
C
V
----
E
-
G
V
L
R
L
T
----
K
S
D
-----------
F
R
E
P
V
N
I
G
S
D
E
M
V
S
M
N
E
M
A
E
M
V
L
S
F
E
E
K
K
L
P
--------
I
-
H
-
H
----
I
P
G
-
P
E
G
V
R
G
R
N
S
D
N
N
L
I
K
E
K
-
L
G
W
A
P
N
M
-
R
L
K
E
G
L
R
I
T
Y
F
W
I
K
E
Q
I
E
K
13
PsiBlast_PDB
73.00
27%
-78
- C1 -
4E5Y
1
FCL_HUMAN
A:
[10-312]
----
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G---
E
D
W
---
V
F
-
V
S
S
--------------------------
K
D
A
-------------
D
L
--
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
---------
G
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
-----
Y
----------
P
I
D
E
T
M
I
H
N
G
P
P
H
N
-
S
N
F
G
Y
S
Y
A
K
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
-
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
S
A
-
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
----
Q
L
F
I
W
V
L
R
----
E
Y
N
-
E
--------
V
E
P
I
I
L
S
V
G
E
E
D
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
--------
V
-
T
-
F
----
D
-----
G
Q
F
K
K
T
A
S
N
S
K
L
R
-
T
-
Y
L
P
D
F
R
F
T
P
F
K
Q
A
V
K
E
T
C
A
W
F
T
D
N
Y
E
Q
47
HHSearch
71.68
19%
-86
- C1 -
1KEW
5
RMLB_SALTY
A:
[1-339]
--
M
K
I
L
I
T
G
G
A
G
F
I
G
S
A
V
V
R
H
I
I
K
N
-------
T
Q
D
-
T
V
-
V
N
I
D
KLTYAGNLESLSDISESNR
Y
-----
N
F
E
-------------
H
A
D
I
C
D
S
A
E
I
T
R
I
F
E
Q
Y
Q
P
D
A
V
M
H
L
A
A
E
S
H
V
D
R
S
I
-
T
G
P
A
A
F
I
E
T
N
I
V
G
T
Y
A
L
L
E
V
A
R
K
Y
W
S
A
LG
E
D
K
K
N
N
F
R
F
H
H
I
S
T
D
E
V
Y
G
D
L
P
H
-----
P
DEVENS
V
T
L
P
L
F
T
E
T
T
----
A
Y
A
P
-
S
S
-
P
Y
S
A
S
K
A
S
S
D
H
L
V
R
A
W
R
R
T
Y
G
L
P
T
I
V
T
N
C
S
N
N
Y
G
-
P
Y
H
F
P
----
E
K
L
I
P
L
V
I
L
N
A
---
L
E
--
G
K
P
L
P
I
Y
G
K
G
D
Q
I
R
D
W
L
Y
V
E
D
H
A
----
R
-
A
L
H
M
V
V
----
T
E
G
----------
K
A
G
E
T
Y
N
I
G
G
H
N
E
K
K
N
L
D
V
V
F
T
I
C
D
L
L
D
E
I
V
P
KATSYREQ
I
-
T
-
Y
----
V
A
D
R
P
G
H
D
R
R
Y
A
I
D
A
G
K
I
S
R
E
-
L
G
W
K
P
L
E
-
T
F
E
S
G
I
R
K
T
V
E
W
Y
L
A
N
T
Q
W
51
HHSearch
69.47
22%
-78
- C1 -
1SB8
2
?
A:
[27-351]
-
P
K
V
W
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
T
L
L
K
L
-------
D
Q
--
K
V
-
V
G
L
D
NFATGH
Q
R
N
L
D
E
V
R
S
L
V
S
E
K
Q
W
S
N
F
K
F
I
-------------
Q
G
D
I
R
N
L
D
D
C
N
N
A
C
A
--
G
V
D
Y
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
-
N
D
P
I
T
S
N
A
T
N
I
D
G
F
L
N
M
L
I
A
A
R
D
A
---------
K
V
Q
S
F
T
Y
A
A
S
S
S
T
Y
G
D
H
P
G
-----
L
----------
P
K
V
E
D
T
----
I
G
K
P
-
L
S
-
P
Y
A
V
T
K
Y
V
N
E
L
Y
A
D
V
F
S
R
C
Y
G
F
S
T
I
G
L
R
Y
F
N
V
F
G
-
R
R
Q
D
P
N
G
A
Y
A
A
V
I
P
K
W
T
S
S
M
---
I
Q
--
G
D
D
V
Y
I
N
G
D
G
E
T
S
R
D
F
C
Y
I
E
N
T
V
----
Q
-
A
N
L
L
A
A
----
T
A
G
L
D
--------
A
R
N
Q
V
Y
N
I
A
V
G
G
R
T
S
L
N
Q
L
F
F
A
L
R
D
G
L
A
E
N
G
V
--------
S
-
Y
H
R
E
P
V
Y
R
D
F
R
E
G
D
V
R
H
S
L
A
D
I
S
K
A
A
K
L
-
L
G
Y
A
P
K
Y
-
D
V
S
A
G
V
A
L
A
M
P
W
Y
I
M
F
L
K
-
43
HHSearch
69.14
19%
-84
- C1 -
2HUN
1
?
A:
[3-315]
-
S
M
K
L
L
V
T
G
G
M
G
F
I
G
S
N
F
I
R
Y
I
L
E
K
-------
H
P
D
W
E
V
-
I
N
I
D
KLGYGSNPANLKDLEDDPR
Y
-----
T
F
V
-------------
K
G
D
V
A
D
Y
E
L
V
K
E
L
V
R
--
K
V
D
G
V
V
H
L
A
A
E
S
H
V
D
R
S
I
-
S
S
P
E
I
F
L
H
S
N
V
I
G
T
Y
T
L
L
E
S
I
R
R
E
N--------
P
E
V
R
F
V
H
V
S
T
D
E
V
Y
G
D
I
L
K
-----
G
----------
S
F
T
E
N
D
----
R
L
M
P
-
S
S
-
P
Y
S
A
T
K
A
A
S
D
M
L
V
L
G
W
T
R
T
Y
N
L
N
A
S
I
T
R
C
T
N
N
Y
G
-
P
Y
Q
F
P
----
E
K
L
I
P
K
T
I
I
R
A
---
S
L
--
G
L
K
I
P
I
Y
G
T
---
V
R
D
W
L
Y
V
E
D
H
V
----
R
-
A
I
E
L
V
L
----
L
K
G
----------
E
S
R
E
I
Y
N
I
S
A
G
E
E
K
T
N
L
E
V
V
K
I
I
L
R
L
M
G
K
G
E
E
--------
L
I
E
-
L
----
V
E
D
R
P
G
H
D
L
R
Y
S
L
D
S
W
K
I
T
R
D
-
L
K
W
R
P
K
Y
-
T
F
D
E
G
I
K
K
T
I
D
W
Y
L
K
N
E
W
W