@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0041: (2015-12-12 )
MCNDATLLNKITLFGVVQGVGMRPFVYILAQKLGLVGFVRNAQAALEIVLPAHKTESFLNALKKGLPPLALVEKIIISPYDKALHFNDFRILESKNHPLNLLSQIPKDLGVCEDCLCEIRDKNSPYFHYAFNSCAKCGARYSLLNAMPYDRENSALKPFKLCKFCASVYKDAHNKRFHIQGISCKKCGIALNYKRFKNDDALLECAKDIQKGKIIALKGLGGFALLCDARNFKTIERLRLLKNRPLKPFALMFKDLNAAKQHAFLNALECESLNSVSAPILLARKKPDTQLAPNIAKNSPFYGVILPYTPLHALLLDLLDSPIVFTSANFSSLPLASDEKEIDSLHFIFDFKLTHNRTIIHRIDDSIAQRVDNAIRPMRLVRGFAPLYLTLPKRSFNAPKKILALGAEQKGHFSLLDSETSVLLLSPFCGDLSVLENEKHFKETLNFFLKTYDFKPTLLACDEHQNYTTTKMAFDFNTPLLQVQHHHAHFLASVLDALLQDPHLNHPFIGIVWDGSGAYENKIYGAECFVGDLERIEEVARFEEFWLLGGQKAIKEPRRLVLEIALKHQLNKLLKRVQKHFKEDELGIFKQMHDKKIQSVATNSIGRLFDIVAFSLGVVGTISFEAESGQVLENLALQSDEIAFYPFEIKNSVVRLKEFYQAFEKDLGVLEPKRIAKKFFNSLVEIITALIAPFKGHVVVCSGGVFCNQLLCEQLAKRLKKLQREYFFHKHFPPNDSSIPVGQALMAYFNPTIIKKG
Atome Classification :
(21 SA)
.........10........20........30........40-....-....50...--.--....60........70.....---...80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.----.----...----..------200...-....210.......220.......230.......240...-....250.......260..---.....270...-....280.......290.......300.......310.......320.-......330....-..-.340.-.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440---.......450....-...460.......470---....----.....480.......490.......500..-.---....510.....-..520-........530.......540.......550.......560..--------.....570.......580--.......590.......600.......610.......-620.......630....-----------...640..-...--.--.---650.........660......----.670.-...--------....680....---...690--.---.....----...700.......710.......720.......730.......740.......750.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MC
N
D
A
T
L
L
N
K
I
T
L
F
G
V
V
QGVGM
R
P
F
V
Y
I
L
A
Q
K
L
G
L
V
G
F
V
RN-A
Q
A
A
-
L
E
I
V
LPAH
K
--
T
--
E
S
F
L
N
A
L
K
KGL
P
P
L
A
L
V
E
K
I
I
---ISPYDKALHFN
D
F
R
I
LESKNH
P
L
N
L
L
S
QI
P
K
D
L
G
V
C
E
D
C
L
C
E
IRDKNS
P
Y
F
H
Y
A
F
N
S
C
A
K
C
G
A
R
Y
S
L
L
NAMPYDRENSAL
K
P
F
K
L
C
K
F
C
A
S
V
Y
K
DAHN
K
R
F
H
I
QGISCKKC
G
I
A
LN
Y
----
K
----RFK----N
D
------
D
A
L
L
E
C
-
A
K
D
IQKG
K
I
I
A
L
KGLG
G
F
A
L
L
CDAR
N
F
K
T
I
E
R
L
R
L
L
KNRP-L
K
P
F
A
L
M
F
K
D
L
N
A
A
K
Q
H
A
F
---
L
N
A
L
E
CESLNS-VSA
P
I
L
L
ARKKPDTQLAPNIAKNSP
F
Y
G
V
ILPY
T
P
L
H
A
L
L
L
D
LLDS
P
I
-
V
F
TSANFSSLPLA-SD-EKE-I-D
S
L
H
F
I
F
D
F
K
LTHNR
T
I
I
H
RI
D
D
S
I
A
Q
R
V
D
NA
I
R
P
M
R
L
V
RGFA
P
L
Y
L
TL
P
K
RSFNA
P
K
K
I
L
A
LGAEQKG
H
F
S
L
LDSET
S
V
L
L
LSPFCG
D
L
S
V
LEN
E
K
H
F
K
---
E
T
L
N
F
F
L
K
TYDFKP-
T
L
L
A
CDEHQNY
T
T
T
-----
K
M
A
F
----DFNTP
L
L
Q
V
Q
H
H
H
A
H
F
L
A
S
V
L
D
A
L
LQDPHL-N---H
P
F
I
G
I
V
WDGSG-AYE-N-KIYG
A
E
C
F
VG
D
L
E
R
I
E
E
V
A
R
F
E
E
F
W
L
LG
G
Q
K
A
I
K
E
P
R
R
L
V
L
E
I
--------
A
L
K
H
Q
L
N
K
L
L
K
R
V
Q
K
H
FK--E
D
E
L
G
I
F
K
Q
M
H
D
K
K
I
Q
S
V
A
T
N
S
I
G
R
L
F
D
I
V
A
F
SLG
V
V
-
G
T
I
S
F
EAES
G
Q
V
L
E
N
LA-----------LQSD
E
I
A
F
-
Y
P
F
--
E
--I---K--
N
S
V
V
R
L
K
E
F
Y
Q
A
F
E
KDLG----VL
E
-
P
-
K
R
I
--------
A
K
K
F
F
N
S
L
V
E
I
---
I
T
A
L
----I---APFKG----
H
V
V
V
CS
G
G
V
F
C
N
Q
L
L
C
E
Q
L
A
K
R
L
K
K
L
Q
R
E
Y
F
F
HKHFPPNDSSI
P
V
G
Q
A
L
M
A
YFNPTIIKKG
60
HHSearch
95.35
34%
-104
- C3 -
3VTH
15
?
A:
[4-750]
G
R
V
P
Q
I
Q
A
R
Q
I
N
I
F
G
I
V
Q
G
V
G
F
R
P
F
V
F
N
I
A
Q
K
Y
N
L
K
G
I
V
Y
N
-
N
S
S
G
-
L
Y
I
E
V
E
G
E
E
K
D
I
--
E
A
F
I
R
E
I
K
E
N
P
P
S
L
S
V
I
D
E
I
Q
---
V
R
E
V
E
V
-
K
E
Y
K
D
F
K
I
V
G
S
K
E
--
D
G
G
F
V
P
V
S
P
D
M
G
V
C
E
D
C
L
R
E
L
K
D
P
K
D
R
R
Y
R
Y
P
F
I
N
C
T
N
C
G
P
R
F
S
I
I
E
D
I
P
Y
D
R
A
K
T
S
M
K
V
F
P
M
C
E
K
C
S
R
E
Y
H
D
P
H
D
R
R
F
H
A
Q
P
V
A
C
F
D
C
G
P
S
L
S
F
----
V
----
G
E
G
C---
F
D
------
D
E
I
K
C
V
-
A
K
A
L
K
E
G
K
I
V
A
I
K
G
I
G
G
F
H
L
A
V
N
A
L
D
D
E
A
V
A
T
L
R
R
R
K
K
R
Y
-
G
K
P
F
A
V
M
M
R
D
V
E
E
V
K
K
Y
C
I
---
V
S
P
E
E
E
R
L
L
L
S
-
Q
R
R
P
I
V
L
L
K
K
K
G
E
-
K
L
A
K
G
I
A
D
D
L
D
T
L
G
V
M
L
P
Y
A
P
I
H
Y
L
L
M
E
E
I
D
F
P
I
-
V
M
T
S
G
N
V
S
E
E
P
I
C
-
K
D
-
N
E
E
-
A
L
E
K
L
K
D
I
A
D
V
F
L
L
N
N
R
D
I
V
N
R
I
D
D
S
V
T
S
F
N
A
G
A
E
R
I
I
R
R
A
R
G
Y
A
P
Q
P
I
L
L
K
K
-
E
V
--
K
A
S
I
L
A
V
G
G
F
Y
K
N
T
F
C
M
T
K
G
H
Y
--
A
F
I
S
H
H
I
G
D
L
D
N
E
K
A
F
N
Y
Y
I
---
E
Q
I
E
R
Y
K
K
L
F
R
V
D
P
-
E
V
V
A
H
D
M
H
K
G
Y
L
S
T
-----
Q
Y
A
K
----
S
L
D
L
P
K
I
E
V
Q
H
H
H
A
H
I
A
S
C
M
A
E
-----
H
N
L
-
D
---
E
K
V
I
G
I
A
Y
D
G
T
G
-
Y
G
T
D
G
-
N
V
W
G
A
E
I
L
V
C
D
L
K
S
F
E
R
I
A
H
L
K
Y
K
P
L
P
G
N
E
L
A
I
K
K
I
Y
R
T
A
L
G
F
--------
I
F
D
N
I
S
F
--
Y
K
N
F
V
E
Q
V
D
--
S
R
E
L
D
I
I
L
K
Q
I
D
R
K
I
N
T
A
Y
V
S
S
M
G
R
F
F
D
A
V
A
A
L
I
G
V
R
-
K
E
V
L
F
E
G
Q
A
A
M
E
L
E
S
L
M
-----------
A
E
S
E
E
Y
---
Y
E
Y
--
E
--
I
L
K
E
D
--
R
Y
V
I
D
P
E
L
I
L
R
Q
I
Y
E
D
Y
M
----
K
G
F
E
K
-
S
Y
I
--------
S
A
K
F
H
N
T
V
V
N
F
---
T
Y
D
L
A
N
L
I
R
---
K
E
T
G
I
----
N
K
V
V
L
S
G
G
S
F
Q
N
R
Y
L
L
R
R
L
I
E
K
L
S
L
S
G
F
E
V
Y
S
N
S
K
V
P
C
N
D
G
G
I
S
L
G
Q
A
V
I
A
N
K
I
L
E
G
S
A
W
S
1
PsiBlast_PDB
94.71
33%
-105
- C3 -
3VTH
15
?
A:
[13-745]
---------
Q
I
N
I
F
G
I
V
Q
G
V
G
F
R
P
F
V
F
N
I
A
Q
K
Y
N
L
K
G
I
V
Y
N
-
N
S
S
G
-
L
Y
I
E
V
E
G
E
E
K
D
I
--
E
A
F
I
R
E
I
K
E
N
P
P
S
L
S
V
I
D
E
I
Q
---
V
R
E
V
E
-
V
K
E
Y
K
D
F
K
I
V
G
S
K
E
D
--
G
G
F
V
P
V
S
P
D
M
G
V
C
E
D
C
L
R
E
L
K
D
P
K
D
R
R
Y
R
Y
P
F
I
N
C
T
N
C
G
P
R
F
S
I
I
E
D
I
P
Y
D
R
A
K
T
S
M
K
V
F
P
M
C
E
K
C
S
R
E
Y
H
D
P
H
D
R
R
F
H
A
Q
P
V
A
C
F
D
C
G
P
S
L
S
F
----
V
----
G
E
G
----
C
F
------
D
D
E
I
K
C
V
A
K
A
L
K
E
G
K
I
V
A
I
K
G
I
G
G
F
H
L
A
V
N
A
L
D
D
E
A
V
A
T
L
R
R
R
K
K
R
Y
-
G
K
P
F
A
V
M
M
R
D
V
E
E
V
K
K
Y
C
I
---
V
S
P
E
E
E
R
L
L
L
S
-
Q
R
R
P
I
V
L
L
K
K
K
G
E
-
K
L
A
K
G
I
A
D
D
L
D
T
L
G
V
M
L
P
Y
A
P
I
H
Y
L
L
M
E
E
I
D
F
P
I
-
V
M
T
S
G
N
V
S
E
E
P
I
C
-
K
D
-
N
E
E
A
L
-
E
K
L
K
D
I
A
D
V
F
L
L
N
N
R
D
I
V
N
R
I
D
D
S
V
T
S
F
N
A
G
A
E
R
I
I
R
R
A
R
G
Y
A
P
Q
P
I
L
L
K
K
---
E
V
K
A
S
I
L
A
V
G
G
F
Y
K
N
T
F
C
M
--
T
K
G
H
Y
A
F
I
S
H
H
I
G
D
---
L
D
N
E
K
A
F
N
Y
Y
I
E
Q
I
E
R
Y
K
K
L
F
R
V
D
P
-
E
V
V
A
H
D
M
H
K
G
Y
L
S
T
-----
Q
Y
A
K
----
S
L
D
L
P
K
I
E
V
Q
H
H
H
A
H
-----
I
A
S
C
M
A
E
H
N
L
-
D
---
E
K
V
I
G
I
A
Y
D
G
T
G
Y
G
T
D
-
G
-
N
V
W
G
A
E
I
L
V
C
D
L
K
S
F
E
R
I
A
H
L
K
Y
K
P
L
P
G
N
E
L
A
I
K
K
I
Y
R
T
A
L
G
F
--------
I
F
D
N
I
--
S
F
Y
K
N
F
V
E
Q
V
D
--
S
R
E
L
D
I
I
L
K
Q
I
D
R
K
I
N
T
A
Y
V
S
S
M
G
R
F
F
D
A
V
A
A
L
I
G
V
R
-
K
E
V
L
F
E
G
Q
A
A
M
E
L
E
S
L
M
AESE
E
Y
Y
E
Y
E
I
L
K
E
D
R
Y
V
I
-
D
P
E
--
L
--
I
-----------
L
R
Q
I
Y
E
D
Y
M
K
G
-------
F
E
-
K
-
S
Y
I
--------
S
A
K
F
H
N
T
V
V
N
F
T
Y
D
L
A
N
L
----
I
---
R
K
E
T
G
I---
N
K
V
V
L
S
G
G
S
F
Q
N
R
Y
L
L
R
R
L
I
E
K
L
S
L
S
G
F
E
V
Y
S
N
S
K
V
P
C
N
D
G
G
I
S
L
G
Q
A
V
I
A
N
K
I
L
E
G
S
A
W
S
21
PsiBlast_CBE
93.89
33%
-106
- C3 -
3VTI
3
?
B:
[13-745]
---------
Q
I
N
I
F
G
I
V
Q
G
V
G
F
R
P
F
V
F
N
I
A
Q
K
Y
N
L
K
G
I
V
Y
N
-
N
S
S
G
-
L
Y
I
E
V
E
G
E
E
KD
I
--
E
A
F
I
R
E
I
K
E
N
P
P
S
L
S
V
I
D
E
I
Q
---
V
R
E
V
E
-
V
K
E
Y
K
D
F
K
I
V
G
S
K
E
D
--
G
G
F
V
P
V
S
P
D
M
G
V
C
E
D
C
L
R
E
L
K
D
P
K
D
R
R
Y
R
Y
P
F
I
N
C
T
N
C
G
P
R
F
S
I
I
E
D
I
P
Y
D
R
A
K
T
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M
K
V
F
P
M
C
E
K
C
S
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Y
H
D
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H
D
R
R
F
H
A
Q
P
V
A
C
F
D
C
G
P
S
L
S
F
----
V
----
G
E
G
----
C
F
------
D
D
E
I
K
C
V
A
K
A
L
K
E
G
K
I
V
A
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G
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G
F
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L
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A
L
D
D
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A
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A
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L
R
R
R
K
K
R
Y
-
G
K
P
F
A
V
M
M
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D
V
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E
V
K
K
Y
C
I
---
V
S
P
E
E
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R
L
L
L
S
-
Q
R
R
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I
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L
L
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K
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G
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-
K
L
A
K
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A
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D
L
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L
G
V
M
L
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Y
A
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I
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L
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I
-
V
M
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G
N
V
S
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-
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L
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L
L
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Y
A
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Q
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I
L
L
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K
---
E
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N
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--
T
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A
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I
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H
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D
---
L
D
N
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A
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N
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E
Q
I
E
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Y
K
K
L
F
R
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D
P
-
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V
V
A
H
D
M
H
K
G
Y
L
S
T
-----
Q
Y
A
K
----
S
L
D
L
P
K
I
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V
Q
H
H
H
A
H
-----
I
A
S
C
M
A
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H
N
L
-
D
---
E
K
V
I
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T
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-
G
-
N
V
W
G
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C
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L
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L
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Y
K
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L
P
G
N
E
L
A
I
K
K
I
Y
R
T
A
L
G
F
--------
I
F
D
N
I
--
S
F
Y
K
N
F
V
E
Q
V
D
--
S
R
E
L
D
I
I
L
K
Q
I
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R
K
I
N
T
A
Y
V
S
S
M
G
R
F
F
D
A
V
A
A
L
I
G
V
R
-
K
E
V
L
F
E
G
Q
A
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L
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S
L
M
AESEEYYEYEI
L
K
E
D
R
Y
V
I
-
D
P
E
--
L
--
I
-----------
L
R
Q
I
Y
E
D
Y
M
K
G
-------
F
E
-
K
-
S
Y
I
--------
S
A
K
F
H
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T
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V
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F
TYD
L
A
N
L
----
I
---
R
K
E
T
G
I---
N
K
V
V
L
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G
G
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Q
N
R
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L
L
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L
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L
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D
G
G
I
S
L
G
Q
A
V
I
A
N
K
I
L
E
G
----
2
PsiBlast_PDB
93.53
33%
-106
- C3 -
3VTI
3
?
A:
[13-745]
---------
Q
I
N
I
F
G
I
V
Q
G
V
G
F
R
P
F
V
F
N
I
A
Q
K
Y
N
L
K
G
I
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Y
N
-
N
S
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G
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L
Y
I
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--
E
A
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I
K
E
N
P
P
S
L
S
V
I
D
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I
Q
---
V
R
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V
E
-
V
K
E
Y
K
D
F
K
I
V
G
S
K
E
D
--
G
G
F
V
P
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D
M
G
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C
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C
L
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L
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D
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K
D
R
R
Y
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Y
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F
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N
C
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N
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I
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Y
D
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A
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M
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V
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P
M
C
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C
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Y
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H
D
R
R
F
H
A
Q
P
V
A
C
F
D
C
G
P
S
L
S
F
----
V
----
G
E
G
----
C
F
------
D
D
E
I
K
C
V
A
K
A
L
K
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G
K
I
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A
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-
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V
K
K
Y
C
I
---
V
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L
L
L
S
-
Q
R
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L
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D
---
L
D
N
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A
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N
Y
Y
I
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Q
I
E
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Y
K
K
L
F
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D
P
-
E
V
V
A
H
D
M
H
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G
Y
L
S
T
-----
Q
Y
A
K
----
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L
D
L
P
K
I
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V
Q
H
H
H
A
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-----
I
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C
M
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L
-
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---
E
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V
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D
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V
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E
L
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K
I
Y
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T
A
L
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F
--------
I
F
D
N
I
--
S
F
Y
K
N
F
V
E
Q
V
D
--
S
R
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L
D
I
I
L
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Q
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R
K
I
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T
A
Y
V
S
S
M
G
R
F
F
D
A
V
A
A
L
I
G
V
R
-
K
E
V
L
F
E
G
Q
A
A
M
E
L
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L
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AESE
E
Y
Y
E
Y
E
I
L
K
E
D
R
Y
V
I
-
D
P
E
--
L
--
I
-----------
L
R
Q
I
Y
E
D
Y
M
K
G
-------
F
E
-
K
-
S
Y
I
--------
S
A
K
F
H
N
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D
L
A
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L
----
I
---
R
K
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N
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L
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G
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L
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Q
A
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A
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K
I
L
E
G
----
3
PsiBlast_PDB
86.82
31%
-91
- C3 -
4G9I
3
?
A:
[6-757]
----------
I
H
V
Q
G
I
V
Q
A
V
G
F
R
P
F
V
Y
R
I
A
H
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--
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A
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L
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G
----
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F
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------
D
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----
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----
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----
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A
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---
V
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----
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--
A
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V
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L
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F
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---
E
A
I
A
H
F
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K
I
L
R
V
K
N
L
D
L
I
I
A
D
L
H
P
A
Y
N
T
T
-----
K
L
A
M
E
M
A
N
E
L
D
V
E
L
L
Q
V
Q
H
H
Y
A
H
I
A
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V
M
A
E
K
N
L
D
S
----------
V
I
G
I
A
L
D
G
V
G
Y
G
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D
-
G
-
N
T
W
G
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L
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G
D
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I
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L
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V
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N
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C
C
P
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A
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L
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YG
K
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F
N
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V
L
N
Q
L
A
K
G
I
N
T
A
Y
A
S
S
T
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R
V
L
D
A
I
A
V
L
L
N
V
A
-
Y
R
R
H
Y
E
G
E
P
A
M
K
L
E
S
F
A
-----------
F
K
G
K
N
D
L
K
-
F
E
V
--
P
--
V
---
E
--
G
E
L
I
R
V
E
E
L
F
Q
S
I
L
E
A
I
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----
G
A
S
-
P
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A
D
I
A
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A
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L
A
L
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A
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A
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E
R
---
A
R
E
-----------
F
G
V
----
K
N
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A
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G
V
A
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Q
A
F
L
G
G
L
Y
L
E
G
Y
L
T
K
8
PsiBlast_PDB
86.46
32%
-92
- C3 -
3TTC
6
?
A:
[12-649]
----------------------------------------------------------------------------------------------------------------
Q
I
V
P
D
A
A
T
C
P
A
C
L
A
E
M
N
T
P
G
E
R
R
Y
R
Y
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F
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T
H
C
G
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A
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M
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C
P
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R
R
F
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A
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P
V
A
C
P
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C
G
P
Y
L
E
W
V
S
HG
E
----
H
A
E
----
Q
E
------
A
A
L
Q
A
A
-
I
A
Q
L
K
M
G
N
I
V
A
I
K
G
I
G
G
F
H
L
A
C
D
A
R
N
S
N
A
V
A
T
L
R
A
R
K
H
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P
-
A
K
P
L
A
V
M
L
P
V
A
D
G
L
P
D
A
A
R
---------
Q
L
L
T
T
-
P
A
A
P
I
V
L
V
D
K
K
Y
V
P
E
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H
L
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---
L
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R
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---
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A
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I
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N
F
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-
Q
Y
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V
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A
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G
Y
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C
-----
Q
W
A
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----
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M
N
L
P
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Q
T
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L
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H
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A
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A
A
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--
A
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H
Q
W
P
L
D
-
G
---
G
D
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I
A
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L
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I
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-
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G
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-
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A
L
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R
V
N
Y
R
E
C
E
H
L
G
G
L
P
A
V
A
L
P
G
G
D
L
A
A
K
Q
P
W
R
N
L
L
A
Q
--------
C
L
R
F
V
P
E
W
Q
N
Y
P
E
T
A
S
V
A
--
A
A
N
W
S
V
L
A
R
A
I
E
R
G
I
N
A
P
L
A
S
S
C
G
R
L
F
D
A
V
A
A
A
L
G
C
A
P
A
T
L
S
Y
E
G
E
A
A
C
A
L
E
A
L
A
-----------
A
S
C
D
G
V
T
--
H
P
V
--
T
--
M
---
P
RV
D
N
Q
L
D
L
A
T
F
W
Q
Q
W
---
L
N
----
W
Q
A
-
P
V
N
Q
R
--------
A
W
A
F
H
D
A
L
A
Q
G
---
F
A
A
L
----
M
R
E
Q
A
T
M
R
G
I---
T
T
L
V
F
S
G
G
V
I
H
N
R
L
L
R
A
R
L
A
H
Y
L
A
D
F
--
T
L
L
F
P
Q
S
L
P
A
G
D
G
G
L
S
L
G
Q
G
V
I
A
A
A
R
W
L
A
G
E
--
6
PsiBlast_PDB
86.40
32%
-92
- C3 -
3TSP
4
?
A:
[12-649]
----------------------------------------------------------------------------------------------------------------
Q
I
V
P
D
A
A
T
C
P
A
C
L
A
E
M
N
T
P
G
E
R
R
Y
R
Y
P
F
I
N
C
T
H
C
G
P
R
F
T
I
I
R
A
M
P
Y
D
R
P
F
T
V
M
A
A
F
P
L
C
P
A
C
D
K
E
Y
R
D
P
L
D
R
R
F
H
A
Q
P
V
A
C
P
E
C
G
P
Y
L
E
W
V
S
HG
E
----
H
A
E
----
Q
E
------
A
A
L
Q
A
A
-
I
A
Q
L
K
M
G
N
I
V
A
I
K
G
I
G
G
F
H
L
A
C
D
A
R
N
S
N
A
V
A
T
L
R
A
R
K
H
R
P
-
A
K
P
L
A
V
M
L
P
V
A
D
G
L
P
D
A
A
R
---------
Q
L
L
T
T
-
P
A
A
P
I
V
L
V
D
K
K
Y
V
P
E
L
C
D
D
I
A
P
G
L
N
E
V
G
V
M
L
P
A
N
P
L
Q
H
L
L
L
Q
E
L
Q
C
P
L
-
V
M
T
S
G
N
L
S
G
K
P
P
A
I
S
N
-
E
Q
A
-
L
-
E
D
L
Q
G
I
A
D
G
F
L
I
H
N
R
D
I
V
Q
R
M
D
D
S
V
V
R
E
S
G
E
M
---
L
R
R
S
R
G
Y
V
P
D
A
L
A
L
P
P
G
F
K
N
V
P
-
P
V
L
C
L
G
A
D
L
K
N
T
F
C
L
V
R
G
E
Q
V
V
--
L
S
Q
H
L
G
D
L
S
D
D
G
I
Q
T
Q
W
R
---
E
A
L
R
L
M
Q
N
I
Y
N
F
T
P
-
Q
Y
V
V
H
D
A
H
P
G
Y
V
S
C
-----
Q
W
A
S
----
E
M
N
L
P
T
Q
T
V
L
H
H
H
A
H
A
A
A
C
L
--
A
E
H
Q
W
P
L
D
-
G
---
G
D
V
I
A
L
T
L
D
G
I
G
-
M
G
E
-
N
G
A
L
W
G
G
E
C
L
R
V
N
Y
R
E
C
E
H
L
G
G
L
P
A
V
A
L
P
G
G
D
L
A
A
K
Q
P
W
R
N
L
L
A
Q
--------
C
L
R
F
V
P
E
W
Q
N
Y
P
E
T
A
S
V
A
--
A
A
N
W
S
V
L
A
R
A
I
E
R
G
I
N
A
P
L
A
S
S
C
G
R
L
F
D
A
V
A
A
A
L
G
C
A
P
A
T
L
S
Y
E
G
E
A
A
C
A
L
E
A
L
A
-----------
A
S
C
D
G
V
T
--
H
P
V
--
T
--
M
---
P
R
V
D
N
Q
L
D
L
A
T
F
W
Q
Q
W
---
L
N
----
W
Q
A
-
P
V
N
Q
R
--------
A
W
A
F
H
D
A
L
A
Q
G
---
F
A
A
L
----
M
R
E
Q
A
T
M
R
G
I---
T
T
L
V
F
S
G
G
V
I
H
N
R
L
L
R
A
R
L
A
H
Y
L
A
D
F
--
T
L
L
F
P
Q
S
L
P
A
G
D
G
G
L
S
L
G
Q
G
V
I
A
A
A
R
W
L
A
G
E
--
22
PsiBlast_CBE
86.33
33%
-96
- C3 -
3VTH
11
?
B:
[103-745]
-------------------------------------------------------------------------------------------------------------
G
F
V
P
V
S
P
D
M
G
V
C
E
D
C
L
R
E
L
K
D
P
K
D
R
R
Y
R
Y
P
F
I
N
C
T
N
C
G
P
R
F
S
I
I
E
D
I
P
Y
D
R
A
K
T
S
M
K
V
F
P
-----
S
R
E
Y
H
D
P
H
D
R
R
F
H
A
Q
P
V
A
------------------------------------
E
I
K
C
V
A
K
A
L
K
E
G
K
I
V
A
I
K
G
I
G
G
F
H
L
A
V
N
A
L
D
D
E
A
V
A
T
L
R
R
R
K
K
R
Y
-
G
K
P
F
A
V
M
M
R
D
V
E
E
V
K
K
Y
C
I
---
V
S
P
E
E
E
R
L
L
L
S
-
Q
R
R
P
I
V
L
L
K
K
K
G
E
-
K
L
A
K
G
I
A
D
D
L
D
T
L
G
V
M
L
P
Y
A
P
I
H
Y
L
L
M
E
E
I
D
F
P
I
-
V
M
T
S
G
N
V
S
E
E
P
I
C
-
K
D
-
N
E
E
A
L
-
E
K
L
K
D
I
A
D
V
F
L
L
N
N
R
D
I
V
N
R
I
D
D
S
V
T
S
F
N
A
G
A
E
R
I
I
R
R
A
R
G
Y
A
P
Q
P
I
L
L
K
K
---
E
V
K
A
S
I
L
A
V
G
G
F
Y
K
N
T
F
C
M
--
T
K
G
H
Y
A
F
I
S
H
H
I
G
D
---
L
D
N
E
K
A
F
N
Y
Y
I
E
Q
I
E
R
Y
K
K
L
F
R
V
D
P
-
E
V
V
A
H
D
M
H
K
G
Y
L
S
T
-----
Q
Y
A
K
----
S
L
D
L
P
K
I
E
V
Q
H
H
H
A
H
-----
I
A
S
C
M
A
E
H
N
L
-
D
---
E
K
V
I
G
I
A
Y
D
G
T
G
Y
G
T
D
-
G
-
N
V
W
G
A
E
I
L
V
C
D
L
K
S
F
E
R
I
A
H
L
K
Y
K
P
L
P
G
N
E
L
A
I
K
K
I
Y
R
T
A
L
G
F
--------
I
F
D
N
I
--
S
F
Y
K
N
F
V
E
Q
V
D
--
S
R
E
L
D
I
I
L
K
Q
I
D
R
K
I
N
T
A
Y
V
S
S
M
G
R
F
F
D
A
V
A
A
L
I
G
V
R
-
K
E
V
L
F
E
G
Q
A
A
M
E
L
E
S
L
M
AESE
E
Y
Y
E
Y
E
I
L
K
E
D
R
Y
V
I
-
D
P
E
--
L
--
I
-----------
L
R
Q
I
Y
E
D
Y
M
K
G
-------
F
E
-
K
-
S
Y
I
--------
S
A
K
F
H
N
T
V
V
N
F
T
Y
D
L
A
N
L
----
I
---
R
K
E
T
G
I---
N
K
V
V
L
S
G
G
S
F
Q
N
R
Y
L
L
R
R
L
I
E
K
L
S
L
S
G
F
E
V
Y
S
N
S
K
V
P
C
N
D
G
G
I
S
L
G
Q
A
V
I
A
N
K
I
L
E
G
S
A
W
S
61
HHSearch
86.22
32%
-90
- C3 -
3TTC
6
?
A:
[12-655]
----------------------------------------------------------------------------------------------------------------
Q
I
V
P
D
A
A
T
C
P
A
C
L
A
E
M
N
T
P
G
E
R
R
Y
R
Y
P
F
I
N
C
T
H
C
G
P
R
F
T
I
I
R
A
M
P
Y
D
R
P
F
T
V
M
A
A
F
P
L
C
P
A
C
D
K
E
Y
R
D
P
L
D
R
R
F
H
A
Q
P
V
A
C
P
E
C
G
P
Y
L
E
W
----
V
----
S
H
G
E
H
A
E
Q
E
------
A
A
L
Q
A
A
-
I
A
Q
L
K
M
G
N
I
V
A
I
K
G
I
G
G
F
H
L
A
C
D
A
R
N
S
N
A
V
A
T
L
R
A
R
K
H
R
P
-
A
K
P
L
A
V
M
L
P
V
A
D
G
L
---------
P
D
A
A
R
Q
L
L
T
T
-
P
A
A
P
I
V
L
V
D
K
K
Y
V
P
E
L
C
D
D
I
A
P
G
L
N
E
V
G
V
M
L
P
A
N
P
L
Q
H
L
L
L
Q
E
L
Q
C
P
L
-
V
M
T
S
G
N
L
S
G
K
P
P
A
-
I
S
-
N
E
Q
-
A
L
E
D
L
Q
G
I
A
D
G
F
L
I
H
N
R
D
I
V
Q
R
M
D
D
S
V
V
R
E
S
G
---
E
M
L
R
R
S
R
G
Y
V
P
D
A
L
A
L
P
P
-
G
F
K
N
V
P
P
V
L
C
L
G
A
D
L
K
N
T
F
C
L
V
R
G
E
Q
--
V
V
L
S
Q
H
L
G
D
L
S
D
D
G
I
Q
T
Q
W
R
---
E
A
L
R
L
M
Q
N
I
Y
N
F
T
P
-
Q
Y
V
V
H
D
A
H
P
G
Y
V
S
C
-----
Q
W
A
S
----
E
M
N
L
P
T
Q
T
V
L
H
H
H
A
H
A
A
A
C
L
A
E
-----
H
Q
W
-
P
LDG
G
D
V
I
A
L
T
L
D
G
I
G
-
M
G
E
N
G
-
A
L
W
G
G
E
C
L
R
V
N
Y
R
E
C
E
H
L
G
G
L
P
A
V
A
L
P
G
G
D
L
A
A
K
Q
P
W
R
N
L
L
A
Q
--------
C
L
R
F
V
P
E
W
Q
N
Y
P
E
T
A
S
V
A
--
A
A
N
W
S
V
L
A
R
A
I
E
R
G
I
N
A
P
L
A
S
S
C
G
R
L
F
D
A
V
A
A
A
L
G
C
A
P
A
T
L
S
Y
E
G
E
A
A
C
A
L
E
A
L
A
-----------
A
S
C
D
G
V
T
--
H
P
V
TM
P
--
R
---
V
--
D
N
Q
L
D
L
A
T
F
W
Q
Q
W
L
N
W
Q
A
------
P
-
V
-
N
Q
R
--------
A
W
A
F
H
D
A
L
A
Q
G
---
F
A
A
L
M
R
E
Q
A
---
T
M
R
G
I
----
T
T
L
V
F
S
G
G
V
I
H
N
R
L
L
R
A
R
L
A
H
Y
L
A
--
D
F
T
L
L
F
P
Q
S
L
P
A
G
D
G
G
L
S
L
G
Q
G
V
I
A
A
A
R
W
L
A
G
E
--
5
PsiBlast_PDB
86.19
32%
-93
- C3 -
3TTD
4
?
A:
[12-649]
----------------------------------------------------------------------------------------------------------------
Q
I
V
P
D
A
A
T
C
P
A
C
L
A
E
M
N
T
P
G
E
R
R
Y
R
Y
P
F
I
N
C
T
H
C
G
P
R
F
T
I
I
R
A
M
P
Y
D
R
P
F
T
V
M
A
A
F
P
L
C
P
A
C
D
K
E
Y
R
D
P
L
D
R
R
F
H
A
Q
P
V
A
C
P
E
C
G
P
Y
L
E
W
V
S
HG
E
----
H
A
E
----
Q
E
------
A
A
L
Q
A
A
-
I
A
Q
L
K
M
G
N
I
V
A
I
K
G
I
G
G
F
H
L
A
C
D
A
R
N
S
N
A
V
A
T
L
R
A
R
K
H
R
P
-
A
K
P
L
A
V
M
L
P
V
A
D
G
L
P
D
A
A
R
---------
Q
L
L
T
T
-
P
A
A
P
I
V
L
V
D
K
K
Y
V
P
E
L
C
D
D
I
A
P
G
L
N
E
V
G
V
M
L
P
A
N
P
L
Q
H
L
L
L
Q
E
L
Q
C
P
L
-
V
M
T
S
G
N
L
S
G
K
P
P
A
I
S
N
-
E
Q
A
-
L
-
E
D
L
Q
G
I
A
D
G
F
L
I
H
N
R
D
I
V
Q
R
M
D
D
S
V
V
R
E
S
G
E
M
---
L
R
R
S
R
G
Y
V
P
D
A
L
A
L
P
P
G
F
K
N
V
P
-
P
V
L
C
L
G
A
D
L
K
N
T
F
C
L
V
R
G
E
Q
V
V
--
L
S
Q
H
L
G
D
L
S
D
D
G
I
Q
T
Q
W
R
---
E
A
L
R
L
M
Q
N
I
Y
N
F
T
P
-
Q
Y
V
V
H
D
A
H
P
G
Y
V
S
C
-----
Q
W
A
S
----
E
M
N
L
P
T
Q
T
V
L
H
H
H
A
H
A
A
A
C
L
--
A
E
H
Q
W
P
L
D
-
G
---
G
D
V
I
A
L
T
L
D
G
I
G
-
M
G
E
-
N
G
A
L
W
G
G
E
C
L
R
V
N
Y
R
E
C
E
H
L
G
G
L
P
A
V
A
L
P
G
G
D
L
A
A
K
Q
P
W
R
N
L
L
A
Q
--------
C
L
R
F
V
P
E
W
Q
N
Y
P
E
T
A
S
V
A
--
A
A
N
W
S
V
L
A
R
A
I
E
R
G
I
N
A
P
L
A
S
S
C
G
R
L
F
D
A
V
A
A
A
L
G
C
A
P
A
T
L
S
Y
E
G
E
A
A
C
A
L
E
A
L
A
-----------
A
S
C
D
G
V
T
--
H
P
V
--
T
--
M
---
P
R
V
D
N
Q
L
D
L
A
T
F
W
Q
Q
W
---
L
N
----
W
Q
A
-
P
V
N
Q
R
--------
A
W
A
F
H
D
A
L
A
Q
G
---
F
A
A
L
----
M
R
E
Q
A
T
M
R
G
I---
T
T
L
V
F
S
G
G
V
I
H
N
R
L
L
R
A
R
L
A
H
Y
L
A
D
F
--
T
L
L
F
P
Q
S
L
P
A
G
D
G
G
L
S
L
G
Q
G
V
I
A
A
A
R
W
L
A
G
E
V
-
80
Fugue
85.93
31%
-89
- C3 -
3TTC
6
?
A:
[12-657]
----------------------------------------------------------------------------------------------------------------
Q
I
V
P
D
A
A
T
C
P
A
C
L
A
E
M
N
T
P
G
E
R
R
Y
R
Y
P
F
I
N
C
T
H
C
G
P
R
F
T
I
I
R
A
M
P
Y
D
R
P
F
T
V
M
A
A
F
P
L
C
P
A
C
D
K
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Y
R
D
P
L
D
R
R
F
H
A
Q
P
V
A
C
P
E
C
G
P
Y
L
E
W
----
V
S
HG
E
H
A
E
----
Q
E
------
A
A
L
Q
A
A
-
I
A
Q
L
K
M
G
N
I
V
A
I
K
G
I
G
G
F
H
L
A
C
D
A
R
N
S
N
A
V
A
T
L
R
A
R
K
H
R
P
-
A
K
P
L
A
V
M
L
P
V
A
D
G
---------
L
P
D
A
A
R
Q
L
L
T
T
-
P
A
A
P
I
V
L
V
D
K
K
Y
V
P
E
L
C
D
D
I
A
P
G
L
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V
G
V
M
L
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A
N
P
L
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L
L
L
Q
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L
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L
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L
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P
P
A
-
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-
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A
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-
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L
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I
A
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F
L
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H
N
R
D
I
V
Q
R
M
D
D
S
V
V
R
E
S
G
E
M
L
R
R
S
R
---
G
Y
V
P
D
A
L
A
L
P
P
-
G
F
K
N
V
P
P
V
L
C
L
G
A
D
L
K
N
T
F
C
L
V
R
G
E
Q
V
V
L
--
S
Q
H
L
G
D
L
S
D
D
G
I
Q
T
Q
W
R
---
E
A
L
R
L
M
Q
N
I
Y
N
F
T
P
-
Q
Y
V
V
H
D
A
H
P
G
Y
V
S
C
-----
Q
W
A
S
----
E
M
N
L
P
T
Q
T
V
L
H
H
H
A
H
A
A
A
C
L
A
E
H
Q
W
P
L
D
---
G
---
G
D
V
I
A
L
T
L
D
G
I
G
M
G
E
N
-
G
-
A
L
W
G
G
E
C
L
R
V
N
Y
R
E
C
E
H
L
G
G
L
P
A
V
A
L
P
G
G
D
L
A
A
K
Q
P
W
R
N
L
L
A
Q
--------
C
L
R
F
V
P
E
W
Q
N
Y
P
E
T
A
S
V
A
--
A
A
N
W
S
V
L
A
R
A
I
E
R
G
I
N
A
P
L
A
S
S
C
G
R
L
F
D
A
V
A
A
A
L
G
C
A
P
A
T
L
S
Y
E
G
E
A
A
C
A
L
E
A
L
A
-----------
A
S
C
D
G
V
T
H
P
V
T
M
--
P
--
R
---
V
--
D
N
Q
L
D
L
A
T
F
W
Q
Q
W
L
N
W
Q
A
------
P
-
V
-
N
Q
R
--------
A
W
A
F
H
D
A
L
A
Q
G
---
F
A
A
L
----
M
---
R
E
Q
A
T
M
R
GI
T
T
L
V
F
S
G
G
V
I
H
N
R
L
L
R
A
R
L
A
H
Y
L
A
D
F
--
T
L
L
F
P
Q
S
L
P
A
G
D
G
G
L
S
L
G
Q
G
V
I
A
A
A
R
W
L
A
G
E
--
4
PsiBlast_PDB
85.68
32%
-93
- C3 -
3TSQ
5
?
A:
[12-649]
----------------------------------------------------------------------------------------------------------------
Q
I
V
P
D
A
A
T
C
P
A
C
L
A
E
M
N
T
P
G
E
R
R
Y
R
Y
P
F
I
N
C
T
H
C
G
P
R
F
T
I
I
R
A
M
P
Y
D
R
P
F
T
V
M
A
A
F
P
L
C
P
A
C
D
K
E
Y
R
D
P
L
D
R
R
F
H
A
Q
P
V
A
C
P
E
C
G
P
Y
L
E
W
V
S
HG
E
----
H
A
E
----
Q
E
------
A
A
L
Q
A
A
-
I
A
Q
L
K
M
G
N
I
V
A
I
K
G
I
G
G
F
H
L
A
C
D
A
R
N
S
N
A
V
A
T
L
R
A
R
K
H
R
P
-
A
K
P
L
A
V
M
L
P
V
A
D
G
L
P
D
A
A
R
---------
Q
L
L
T
T
-
P
A
A
P
I
V
L
V
D
K
K
Y
V
P
E
L
C
D
D
I
A
P
G
L
N
E
V
G
V
M
L
P
A
N
P
L
Q
H
L
L
L
Q
E
L
Q
C
P
L
-
V
M
T
S
G
N
L
S
G
K
P
P
A
I
S
N
-
E
Q
A
-
L
-
E
D
L
Q
G
I
A
D
G
F
L
I
H
N
R
D
I
V
Q
R
M
D
D
S
V
V
R
E
S
G
E
M
---
L
R
R
S
R
G
Y
V
P
D
A
L
A
L
P
P
G
F
K
N
V
P
-
P
V
L
C
L
G
A
D
L
K
N
T
F
C
L
V
R
G
E
Q
V
V
--
L
S
Q
H
L
G
D
L
S
D
D
G
I
Q
T
Q
W
R
---
E
A
L
R
L
M
Q
N
I
Y
N
F
T
P
-
Q
Y
V
V
H
D
A
H
P
G
Y
V
S
C
-----
Q
W
A
S
----
E
M
N
L
P
T
Q
T
V
L
H
H
H
A
H
A
A
A
C
L
--
A
E
H
Q
W
P
L
D
-
G
---
G
D
V
I
A
L
T
L
D
G
I
G
-
M
G
E
-
N
G
A
L
W
G
G
E
C
L
R
V
N
Y
R
E
C
E
H
L
G
G
L
P
A
V
A
L
P
G
G
D
L
A
A
K
Q
P
W
R
N
L
L
A
Q
--------
C
L
R
F
V
P
E
W
Q
N
Y
P
E
T
A
S
V
A
--
A
A
N
W
S
V
L
A
R
A
I
E
R
G
I
N
A
P
L
A
S
S
C
G
R
L
F
D
A
V
A
A
A
L
G
C
A
P
A
T
L
S
Y
E
G
E
A
A
C
A
L
E
A
L
A
-----------
A
S
C
D
G
V
T
--
H
P
V
--
T
--
M
---
P
R
V
D
N
Q
L
D
L
A
T
F
W
Q
Q
W
---
L
N
----
W
Q
A
-
P
V
N
Q
R
--------
A
W
A
F
H
D
A
L
A
Q
G
---
F
A
A
L
----
M
R
E
Q
A
T
M
R
G
I---
T
T
L
V
F
S
G
G
V
I
H
N
R
L
L
R
A
R
L
A
H
Y
L
A
D
F
--
T
L
L
F
P
Q
S
L
P
A
G
D
G
G
L
S
L
G
Q
G
V
I
A
A
A
R
W
L
A
G
E
V
-
9
PsiBlast_PDB
85.61
32%
-92
- C3 -
3TTF
5
?
A:
[12-649]
----------------------------------------------------------------------------------------------------------------
Q
I
V
P
D
A
A
T
C
P
A
C
L
A
E
M
N
T
P
G
E
R
R
Y
R
Y
P
F
I
N
C
T
H
C
G
P
R
F
T
I
I
R
A
M
P
Y
D
R
P
F
T
V
M
A
A
F
P
L
C
P
A
C
D
K
E
Y
R
D
P
L
D
R
R
F
H
A
Q
P
V
A
C
P
E
C
G
P
Y
L
E
W
V
S
HG
E
----
H
A
E
----
Q
E
------
A
A
L
Q
A
A
-
I
A
Q
L
K
M
G
N
I
V
A
I
K
G
I
G
G
F
H
L
A
C
D
A
R
N
S
N
A
V
A
T
L
R
A
R
K
H
R
P
-
A
K
P
L
A
V
M
L
P
V
A
D
G
L
P
D
A
A
R
---------
Q
L
L
T
T
-
P
A
A
P
I
V
L
V
D
K
K
Y
V
P
E
L
C
D
D
I
A
P
G
L
N
E
V
G
V
M
L
P
A
N
P
L
Q
H
L
L
L
Q
E
L
Q
C
P
L
-
V
M
T
S
G
N
L
S
G
K
P
P
A
I
S
N
-
E
Q
A
-
L
-
E
D
L
Q
G
I
A
D
G
F
L
I
H
N
R
D
I
V
Q
R
M
D
D
S
V
V
R
E
S
G
E
M
---
L
R
R
S
R
G
Y
V
P
D
A
L
A
L
P
P
G
F
K
N
V
P
-
P
V
L
C
L
G
A
D
L
K
N
T
F
C
L
V
R
G
E
Q
V
V
--
L
S
Q
H
L
G
D
L
S
D
D
G
I
Q
T
Q
W
R
---
E
A
L
R
L
M
Q
N
I
Y
N
F
T
P
-
Q
Y
V
V
H
D
A
H
P
G
Y
V
S
C
-----
Q
W
A
S
----
E
M
N
L
P
T
Q
T
V
L
H
H
H
A
H
A
A
A
C
L
--
A
E
H
Q
W
P
L
D
-
G
---
G
D
V
I
A
L
T
L
D
G
I
G
-
M
G
E
-
N
G
A
L
W
G
G
E
C
L
R
V
N
Y
R
E
C
E
H
L
G
G
L
P
A
V
A
L
P
G
G
D
L
A
A
K
Q
P
W
R
N
L
L
A
Q
--------
C
L
R
F
V
P
E
W
Q
N
Y
P
E
T
A
S
V
A
--
A
A
N
W
S
V
L
A
R
A
I
E
R
G
I
N
A
P
L
A
S
S
C
G
R
L
F
D
A
V
A
A
A
L
G
C
A
P
A
T
L
S
Y
E
G
E
A
A
C
A
L
E
A
L
A
-----------
A
S
C
D
G
V
T
--
H
P
V
--
T
--
M
---
P
R
V
D
N
Q
L
D
L
A
T
F
W
Q
Q
W
---
L
N
----
W
Q
A
-
P
V
N
Q
R
--------
A
W
A
F
H
D
A
L
A
Q
G
---
F
A
A
L
----
M
R
E
Q
A
T
M
R
G
I---
T
T
L
V
F
S
G
G
V
I
H
N
R
L
L
R
A
R
L
A
H
Y
L
A
D
F
--
T
L
L
F
P
Q
S
L
P
A
G
D
G
G
L
S
L
G
Q
G
V
I
A
A
A
R
W
L
A
G
E
--
7
PsiBlast_PDB
85.20
32%
-91
- C3 -
3TSU
6
?
A:
[12-649]
----------------------------------------------------------------------------------------------------------------
Q
I
V
P
D
A
A
T
C
P
A
C
L
A
E
M
N
T
P
G
E
R
R
Y
R
Y
P
F
I
N
C
T
H
C
G
P
R
F
T
I
I
R
A
M
P
Y
D
R
P
F
T
V
M
A
A
F
P
L
C
P
A
C
D
K
E
Y
R
D
P
L
D
R
R
F
H
A
Q
P
V
A
C
P
E
C
G
P
Y
L
E
W
V
S
HG
E
----
H
A
E
----
Q
E
------
A
A
L
Q
A
A
-
I
A
Q
L
K
M
G
N
I
V
A
I
K
G
I
G
G
F
H
L
A
C
D
A
R
N
S
N
A
V
A
T
L
R
A
R
K
H
R
P
-
A
K
P
L
A
V
M
L
P
V
A
D
G
L
P
D
A
A
R
---------
Q
L
L
T
T
-
P
A
A
P
I
V
L
V
D
K
K
Y
V
P
E
L
C
D
D
I
A
P
G
L
N
E
V
G
V
M
L
P
A
N
P
L
Q
H
L
L
L
Q
E
L
Q
C
P
L
-
V
M
T
S
G
N
L
S
G
K
P
P
A
I
S
N
-
E
Q
A
-
L
-
E
D
L
Q
G
I
A
D
G
F
L
I
H
N
R
D
I
V
Q
R
M
D
D
S
V
V
R
E
S
G
E
M
---
L
R
R
S
R
G
Y
V
P
D
A
L
A
L
P
P
G
F
K
N
V
P
-
P
V
L
C
L
G
A
D
L
K
N
T
F
C
L
V
R
G
E
Q
V
V
--
L
S
Q
H
L
G
D
L
S
D
D
G
I
Q
T
Q
W
R
---
E
A
L
R
L
M
Q
N
I
Y
N
F
T
P
-
Q
Y
V
V
H
D
A
H
P
G
Y
V
S
C
-----
Q
W
A
S
----
E
M
N
L
P
T
Q
T
V
L
H
H
H
A
H
A
A
A
C
L
--
A
E
H
Q
W
P
L
D
-
G
---
G
D
V
I
A
L
T
L
D
G
I
G
-
M
G
E
-
N
G
A
L
W
G
G
E
C
L
R
V
N
Y
R
E
C
E
H
L
G
G
L
P
A
V
A
L
P
G
G
D
L
A
A
K
Q
P
W
R
N
L
L
A
Q
--------
C
L
R
F
V
P
E
W
Q
N
Y
P
E
T
A
S
V
A
--
A
A
N
W
S
V
L
A
R
A
I
E
R
G
I
N
A
P
L
A
S
S
C
G
R
L
F
D
A
V
A
A
A
L
G
C
A
P
A
T
L
S
Y
E
G
E
A
A
C
A
L
E
A
L
A
-----------
A
S
C
D
G
V
T
--
H
P
V
--
T
--
M
---
P
RV
D
N
Q
L
D
L
A
T
F
W
Q
Q
W
---
L
N
----
W
Q
A
-
P
V
N
Q
R
--------
A
W
A
F
H
D
A
L
A
Q
G
---
F
A
A
L
----
M
R
E
Q
A
T
M
R
G
I---
T
T
L
V
F
S
G
G
V
I
H
N
R
L
L
R
A
R
L
A
H
Y
L
A
D
F
--
T
L
L
F
P
Q
S
L
P
A
G
D
G
G
L
S
L
G
Q
G
V
I
A
A
A
R
W
L
A
G
E
--
69
HHSearch
47.06
19%
-102
- C3 -
3ZEU
2
?
B:
[72-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
-
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
-----
D
N
P
P
E
F--
P
F
V
A
L
L
V
S
G
G
H
------------
T
Q
L
I
S
V
T
G
-----
I
----------
G
--------------------------------------------
Q
Y
E
L
L
G
--------
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
-
Y
----
P
G
G
--
P
M
L
S
K
M
A
-----------
S
Q
G
T
A
G
R
--
F
V
F
--
P
RP
M
TDR
P
--
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
S
N
GG
D
E
Q
T
R
-
A
D
I
--------
A
R
A
F
E
D
A
V
V
D
T
---
L
M
I
K
C
K
R
A
L
---
E
S
T
G
F
----
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
R
R
G
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
V
T
A
D
L
11
PsiBlast_PDB
45.98
40%
-107
- C3 -
1GXU
1
HYPF_ECOLI
A:
[10-79]
---------
Q
L
R
I
R
G
K
V
Q
G
V
G
F
R
P
F
V
W
Q
L
A
Q
Q
L
N
L
H
G
D
V
C
N
-
D
G
D
G
-
V
E
V
R
L
-
R
E
D
--
P
--
E
V
F
L
V
Q
L
Y
Q
H
C
P
P
L
A
R
I
D
S
V
E
---
R
E
P
F
I
W
S
A
L
P
T
E
F
T
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
45.96
40%
-103
- C3 -
1GXT
3
HYPF_ECOLI
A:
[10-79]
---------
Q
L
R
I
R
G
K
V
Q
G
V
G
F
R
P
F
V
W
Q
L
A
Q
Q
L
N
L
H
G
D
V
C
N
-
D
G
D
G
-
V
E
V
R
L
-
R
E
D
--
P
--
E
V
F
L
V
Q
L
Y
Q
H
C
P
P
L
A
R
I
D
S
V
E
---
R
E
P
F
I
W
S
Q
L
P
T
E
F
T
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
HHSearch
44.81
15%
-100
- C3 -
3EN9
1
KAE1B_METJA
A:
[72-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
-
D
L
I
A
F
S
Q
G
P
G
L
G
P
S
L
R
V
T
A
T
V
A
R
T
L
S
L
T
L
K
K
P
I
I
G
V
N
H
C
I
A
H
I
E
I
G
K
L
T
-----
T
E
A
-----
E
D
P
L
T
L
Y
V
S
G
G
N
-
T
Q
-----------
V
I
A
Y
V
-----
S
----------
K
--------------------------------------------
K
Y
R
V
F
G
E
--------
T
L
D
I
A
V
G
N
C
L
D
Q
F
A
R
Y
V
N
L
P
-
H
----
P
G
G
P
Y
--
I
E
E
L
A
-----------
R
K
G
K
K
L
V
D
-
L
P
Y
--
T
--
V
---
K
--
G
M
D
I
A
F
S
G
L
L
T
A
A
M
R
A
Y
D
----
A
G
E
R
L
-
E
D
I
--------
C
Y
S
L
Q
E
Y
A
F
S
M
---
L
T
E
I
T
E
R
A
L
---
A
H
T
N
K
----
G
E
V
M
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
K
A
M
C
E
G
Q
N
V
D
F
Y
V
P
--
P
K
E
F
C
G
D
N
G
A
M
I
A
W
L
G
L
L
M
H
K
N
G
R
W
M
81
Fugue
44.61
35%
-100
- C3 -
1GXU
1
HYPF_ECOLI
A:
[4-91]
---
N
T
S
C
G
V
Q
L
R
I
R
G
K
V
Q
G
V
G
F
R
P
F
V
W
Q
L
A
Q
Q
L
N
L
H
G
D
V
C
N
-
D
G
D
G
-
V
E
V
R
L
R
E
-
D
--
P
--
E
V
F
L
V
Q
L
Y
Q
H
C
P
P
L
A
R
I
D
S
V
E
---
R
E
P
F
I
W
S
A
L
P
T
E
F
T
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
HHSearch
44.42
22%
-66
- C3 -
1HRU
1
TSAC_ECOLI
A:
[7-188]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
------
D
A
I
A
A
A
-
I
D
V
L
N
E
E
R
V
I
A
Y
P
T
E
A
V
F
G
V
G
C
D
P
D
S
E
T
A
V
M
R
L
L
E
L
K
Q
R
P
V
D
K
G
L
I
L
I
A
A
N
Y
E
Q
L
K
P
Y
I
D
DTM
L
T
D
V
Q
R
E
T
I
F
S
R
W
P
G
P
V
T
F
V
F
P
A
P
A
-
T
T
P
R
W
L
T
G
R
F
D
S
L
A
V
R
V
T
D
H
P
L
V
V
A
L
C
Q
A
Y
G
K
P
L
-
V
S
T
S
A
N
L
S
G
L
P
P
C
-
R
T
-
V
D
E
-
V
R
A
Q
F
G
A
A
F
P
-
V
V
P
G
E
T
-
G
G
R
L
N
P
S
E
I
R
D
A
L
T
G
--
E
L
F
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
HHSearch
42.33
32%
-96
- C3 -
1W2I
2
ACYP_PYRHO
A:
[2-90]
----
A
I
V
R
A
H
L
K
I
Y
G
R
V
Q
G
V
G
F
R
W
S
M
Q
R
E
A
R
K
L
G
V
N
G
W
V
R
N
-
L
P
D
G
S
V
E
A
V
L
E
G
D
E
E
R
V
--
E
A
L
I
G
W
A
H
-
Q
G
P
P
L
A
R
V
T
R
V
E
---
V
K
W
E
Q
P
-
K
G
E
K
G
F
R
I
V
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------