@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0048: (2015-12-12 )
MQKIIEDSLELAKKLQDSISNHLSEQEKAFHFKMQKLLNNPENKVMLIELMDRSFRCLDNKARFEMIEHVLDKYKSREIFSSFEKWLLMGFLSFGKMLPDMSVPFFVNKIRSDTKAMVLDQEESQLRERILKRKNEKIILNVNFIGEEVLGEEEASARFEKYSQALKSNYIQYISIKITTIFSQINILDFEYSKKEIVKRLDALYALALEEEKKQGMPKFINLDMEEFRDLELTVESFMESIAKFDLNAGIVLQAYIPDSYEYLKKLHAFSKERVLKGLKPIKIRFVKGANMESEETIASMKDWALPTFSSKQDTDSNYNKMLDFVLEGDNYKYIHIGAASHNIFEIAYVYTRIHALNDPVVLEHFSFEMLEGMSLQASQELKEMHKLILYAPVCDEAHFNNAIAYLVRRLDENTSSDNFMKAFFNLKVGTSEWKDQEQRFLNSLKGIATLDNTTHRTQDRNAKQTGHTTYPNHSFKNESDTDFILKANREWAKKVRDKMHNAPILELYPEIDGRFEDPNLTPLEVFDRIHHKKIASVHLADKEAILKALEVAKSDKSRFSQKSFTEIHALLSQTAQLFRERRGDLIGISALEVGKTFAETDAEVSEAIDFLEFYPYSLRVLQEQNKKTKFTPKGVGVVIAPWNFPVGISVGTIAAPLAAGNRVIYKPSSLSSVTGYKLCECFWDAGVPRDALIYLPSKGSDISEHLLKDESIKFAILTGGEDTAYKMLKANPTLALSAETGGKNATIVSKMADRDQAIKNVIHSAFSNSGQKCSATSLLVLEKEVYEDENFKKTLIDATLSLSVGDPFDFKNKIGALADKPNEKVIKAIDELKSYENYEIPASFVDDNPYLMKPSIKYGTKKGDFTHQTELFTPILSVMKAKDLDEAIEIVNSTGYGLTSALESLDEREWEYYLERIEAGNIYINKPTTGAIVLRQPFGGVKKSAVGFGRKVGIFNYITQFVNIHQEEEDENALKNPLSEALEGLTQKGYDEHTHELKRAIFMAKSYAYHYKHEFSQAKDYVKIRGEDNLFSYTKVTSVGYRITEKDTLSDMLGVALACLISQIPLTISIENERANKDLTFFLECLKALQANAPIVYESLQKFSEKLNAFNRVRYLKSDLDLLHEQASRLGMVLATAKPCLNGRFELLYYHLERSVSISYHRYGNLGSRVLRQPTCHKSCCAEK
Atome Classification :
(37 SA)
....--------.....10........20........30........40........50......--..60........70.....-------...80----......-----------.---.90.------------------.......100...-.----...110.-----......120.......130.--......140.......150.......160..---....----------.170.---------------------......180.......190.......200.......210.......220.......230.......240..--.-.--.-.----.250.......260.......270.......280.......290.......300...-....310.......320.......330.......340.......350.......360.......370.......380.-...--....390.......400.......410.......420.......430-.......440.......450.......460.....-..470...-....480.......490...----....500.-...---------...510.......520.......530.-.......540.......550.......560.......570.......580.......590.......600.......610...---------------....-620--------.----------..----------....630------.........640-........650.......660.......670.......680.......690.......700.......710.......720.......----730------.--------.--------....----..--------.740.......750.......760.......770.......780.......790.......800.......810.......820..-.-.....830......---.840.......850.......860.......870.......880-..--......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
Q
K
I
--------
I
E
D
S
L
E
L
A
K
K
L
Q
D
S
I
S
N
H
L
S
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Q
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K
A
F
H
F
K
M
Q
K
L
LNNPEN
K
V
M
L
I
E
L
M
D
R
S
F
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C--LD
N
K
A
R
F
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M
I
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H
V
L
D
K
Y
K
S
-------
R
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I
F
S
----
S
F
E
K
W
L
-----------
L
---
M
G
F
L
------------------
S
F
G
K
MLPDMS
V
P
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-
F
----
V
N
K
IRSD-----T
K
A
M
V
LD
Q
E
E
S
Q
L
R
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R
I
L
K
R--KN
E
K
I
I
L
N
V
N
FI
G
E
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VLG
E
E
E
A
S
A
R
F
E
K
Y
S
Q
---
A
L
K
S----------N
Y
I
Q
Y
---------------------
I
S
I
K
I
T
T
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F
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Q
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N
I
L
DFEY
S
K
K
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K
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L
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KGLK
P
I
K
I
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VKGANME
S
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T
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M
K
DWA-LPTFSSKQDTDS
N
Y
N
K
M
L
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EGD
N
Y
K
Y
I
H
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GAASH
N
I
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Y
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HALND
P
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HF
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YAPVCDEAHFN
N
A
I
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LDENTSS
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A
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KVGTS-E
W
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SLKG
I
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TLDNTTHRTQDRNAKQTG-HTTYPNHS-FKNESDT
D
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KA
N
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----
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MHNA-
P
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---------
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T
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L
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-
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K
KI
A
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A
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FY---------------
P
Y
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L
-
R
V
L
--------
Q
----------EQ----------NKKTK--------FTPKG
V
G
V
V
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P
V
G
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N
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Y
K
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C
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C
F
W
DAGVPR
D
A
L
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D
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H
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LKDES
I
K
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L
TGGE
D
T
A
Y
K
M
L----K--------A--------N--------
P
T
L
A
----
L
S
--------AETGGK
N
A
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V
S
K
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N
F
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N
-
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SYEN---YEI
P
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SFVDDNP
Y
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MKPSIKYGTKKGDFT
H
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N
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G
A
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RQPFGGV
K
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VGFGRKV
G
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IHQEE
E
D
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N
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L
K
N
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A
L
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L
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Y
D
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H
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M
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Y
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Y
H
Y
K
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D
Y
V
K
I
RGEDN
L
F
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Y
T
K
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G
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ITE
K
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V
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L
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P
L
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K
D
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F
L
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P
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K
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L
L
H
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G
M
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ATA
K
P
C
LNG
R
F
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L
L
Y
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S
V
S
I
S
Y
HRYG
N
L
G
S
R
V
LRQPTC
H
K
S
CCAEK
1
PsiBlast_PDB
88.76
29%
-50
- C3 -
4NM9
14
?
A:
[26-981]
-----------------------
K
P
S
L
F
N
K
G
A
W
M
G
K
A
M
D
W
S
M
Q
----
N
E
Q
F
K
I
Q
M
F
R
F
V
D
-
V
F
P
S
--
L
T
T
S
K
L
--
L
T
E
H
I
-------------
R
E
Y
F
G
----
N
E
Q
D
-------------
M
---
P
-----------------------------------------
N
K
V
L
T
S
N
I
E
E
M
A
R
Q
F
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G
E
T
T
K
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N
L
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L
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A
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Y
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N
T
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L
E
L
L
E
A
L
K
K
----------
E
Q
G
S
W
KGLPGKGGDPGLDWGHAPK
V
N
I
A
V
K
P
T
A
L
F
C
L
A
N
P
Q
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F
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G
S
V
V
A
I
L
D
R
M
R
R
I
F
K
K
V
M
E
------
L
N
G
F
L
C
I
D
M
E
S
Y
R
H
K
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I
I
L
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V
F
R
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L
K
L
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--
Y
-
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DY
P
-
H
----
L
G
I
V
L
Q
A
Y
L
K
D
N
D
K
D
L
D
D
L
L
A
W
A
K
E
H
K
V
Q
----
I
S
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R
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V
K
G
A
Y
W
D
Y
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A
K
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N
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A
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--
N
H
Q
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F
A
C
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H
N
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T
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S
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V
M
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M
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R
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L
N
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M
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K
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R
I
R
L
Y
A
P
Y
---
G
N
M
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G
M
G
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R
R
L
L
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N
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L
R
Q
S
F
A
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D
A
--------
Q
I
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R
L
L
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D
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P
A
V
T
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R
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R
A
A
R
A
A
K
------
G
-
L
G
G
L
P
--
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N
N
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A
M
V
D
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P
L
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K
E
V
R
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N
D
L
I
P
T
V
N
-----
P
N
-
K
P
S
E
V
L
G
Q
I
C
----
Q
A
G
T
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V
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A
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A
A
A
K
A
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F
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A
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L
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D
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Y
---------------
A
R
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M
I
R
L
G
--------
Q
----------
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Q
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PG
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NV
K
K
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Y
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P
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A
G
E
G
--
Y
F
V
P
M
T
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G
I
K
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H
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A
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G
A
R
M
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R
R
G
F
A
P
I
E
E
D
D
D
W
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.05
29%
-51
- C3 -
4NMB
3
?
A:
[26-981]
-----------------------
K
P
S
L
F
N
K
G
A
W
M
G
K
A
M
D
W
S
M
Q
----
N
E
Q
F
K
I
Q
M
F
R
F
V
D
-
V
F
P
S
--
L
T
T
S
K
L
--
L
T
E
H
I
-------------
R
E
Y
F
G
----
N
E
Q
D
-------------
M
---
P
A
F
M
-------------------------------A
V
----
L
N
K
V
L
T
S
N
I
E
E
M
A
R
Q
F
I
V
G
E
T
T
K
E
A
V
K
N
L
E
K
L
--
R
K
D
G
F
A
A
V
V
D
V
L
G
E
A
T
L
S
E
E
E
A
E
V
Y
T
N
T
Y
L
E
L
L
E
A
L
K
K
----------
E
Q
G
S
W
KGLPGKGGDPGLDWGHAPK
V
N
I
A
V
K
P
T
A
L
F
C
L
A
N
P
Q
D
F
E
G
S
V
V
A
I
L
D
R
M
R
R
I
F
K
K
V
M
E
------
L
N
G
F
L
C
I
D
M
E
S
Y
R
H
K
E
I
I
L
E
V
F
R
R
L
K
L
E
--
Y
-
R
DY
P
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H
----
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G
I
V
L
Q
A
Y
L
K
D
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L
L
A
W
A
K
E
H
K
V
Q
----
I
S
V
R
L
V
K
G
A
Y
W
D
Y
E
T
V
K
A
K
Q
N
D
W
E
-
V
P
V
W
T
I
K
A
E
S
D
A
A
Y
E
R
Q
A
R
K
I
L
E
--
N
H
Q
I
C
H
F
A
C
A
S
H
N
I
R
T
I
S
A
V
M
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M
A
R
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L
N
V
P
E
--
D
R
Y
E
F
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V
L
Y
G
M
A
E
P
V
R
K
G
I
L
-
K
V
A
--
G
R
I
R
L
Y
A
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Y
---
G
N
M
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P
G
M
G
Y
L
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R
R
L
L
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N
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F
L
R
Q
S
F
A
E
D
A
--------
Q
I
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R
L
L
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D
-
P
A
V
T
V
E
R
E
R
A
A
R
-----------
L
G
G
L
P
--
P
-
F
N
N
E
A
M
V
D
F
T
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A
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A
A
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A
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L
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K
T
Y
P
L
F
I
NG
K
E
V
R
T
N
D
L
I
P
T
V
N
-----
P
N
-
K
P
S
E
V
L
G
Q
I
C
----
Q
A
G
T
T
E
V
G
D
A
I
A
A
A
K
A
A
F
P
A
W
R
D
T
D
P
R
T
R
A
E
Y
------
L
L
K
A
A
Q
A
A
R
K
R
L
F
E
L
S
A
W
Q
V
L
E
I
G
K
Q
W
D
Q
A
Y
A
D
V
T
E
A
I
D
F
L
E
Y
Y
---------------
A
R
E
M
I
R
L
G
--------
Q
----------
P
Q
----------
R
V
G
H
A
PG
E
L
N
H
Y
F
Y
E
P
K
G
V
A
A
V
I
A
--
P
W
N
F
P
L
A
I
S
M
G
M
A
S
A
A
I
V
T
G
N
C
V
V
F
K
P
S
G
I
T
S
I
I
G
W
H
L
V
E
L
F
R
E
A
G
L
P
E
G
V
F
N
F
T
P
G
R
G
S
V
M
G
D
Y
L
V
D
H
P
D
I
S
L
I
A
F
T
G
S
M
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T
G
L
R
I
I
E
R
A
A
K
--------
V
--------
H
--------
P
G
Q
A
NV
K
K
I
I
--------
S
E
M
G
G
K
N
A
I
I
I
D
D
D
A
D
L
D
E
A
V
P
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A
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C
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I
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L
D
A
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--
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A
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HVL
Y
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P
A
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G
--
Y
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P
M
T
I
I
G
G
I
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R
I
A
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F
G
P
V
L
A
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--
A
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--
D
F
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A
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A
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N
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G
G
A
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--
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A
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G
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D
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L
L
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V
T
E
N
T
M
R
R
G
F
A
P
I
E
E
D
D
D
W
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Fugue
86.34
26%
-46
- C3 -
4Q71
7
?
A:
[3-990]
M
P
N
I
PPPFTAPY
A
P
D
D
A
E
I
A
A
R
L
L
P
A
-
S
H
L
S
P
P
Q
E
A
R
I
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R
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A
T
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L
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A
I
R
K
R
L
G
G
V
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M
L
R
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A
L
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T
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L
A
L
M
V
L
A
E
A
L
L
R
V
P
D
A
-------
R
T
A
D
Q
----
F
I
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D
K
L
GEGD
F
I
H
H
E
T
K
S
---
T
A
F
L
V
NASAWAR
V
I
Q
P
GETPDG
T
I
G
R
L
V
K
R
L
G
A
P
A
-
V
----
R
T
A
T
R
Q
A
-----
M
R
L
M
G
N
H
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L
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E
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A
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M
L
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E
G
A
R
T
A
A
D
A
R
R
Y
F
D
A
Y
A
S
---
A
I
E
T
----------
I
G
K
A
A
GNHALPD
R
P
G
-----------
I
S
V
K
L
S
A
L
H
P
R
F
E
----
A
I
S
R
A
R
V
M
V
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L
V
P
Q
L
L
D
L
A
Q
R
A
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A
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--
N
F
T
V
D
A
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E
A
D
R
L
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L
S
L
D
V
I
A
A
T
L
A
D
--
P
-
S
--
L
-
K
GWDG
F
G
L
A
I
Q
A
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Q
K
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A
S
A
V
I
D
Y
V
D
A
L
A
R
A
H
----
D
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L
M
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R
L
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A
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W
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A
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V
A
C
A
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L
L
A
--
L
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P
R
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F
P
Q
F
A
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H
N
A
L
T
V
A
T
V
L
E
M
A
E
G
S
S
G
------
F
E
F
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H
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M
G
E
A
L
Y
E
Q
-
L
-
A
K
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--
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A
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A
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L
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R
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G
A
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A
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R
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V
P
-
A
L
L
Q
R
P
A
D
A
I
------------------
V
R
P
Q
A
A
A
-
H
P
R
I
P
L
-------------------
P
C
D
L
----
F
A
P
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R
N
S
-
R
G
V
---------
E
F
-------------
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A
R
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A
L
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L
L
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T
-
D
V
K
A
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A
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A
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A
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A
A
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A
A
A
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A
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F
A
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W
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A
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I
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A
A
A
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A
A
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L
L
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R
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A
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A
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L
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R
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G
G
K
T
L
D
D
A
L
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L
R
E
A
A
D
F
C
R
Y
Y
---------------
A
A
Q
G
-
R
K
L
FG
S
E
T
A
M
P
G
----------
P
T
----------
G
E
S
N
A
--------
L
T
M
R
G
R
G
V
F
V
A
I
S
P
W
N
F
P
L
A
I
F
L
G
Q
V
T
A
A
L
M
A
G
N
S
V
V
A
K
P
A
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T
P
R
I
A
R
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A
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A
L
L
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A
G
I
P
K
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A
-
L
Y
L
V
T
G
D
G
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A
A
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A
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P
D
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A
G
V
V
F
T
G
S
T
E
V
A
R
S
I
N
----
R
--------
A
L
A
A
KD---
G
--------
P
I
V
P
----
L
I
--------
A
E
T
G
G
I
N
A
M
I
A
D
A
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A
L
P
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A
D
W
V
V
T
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A
F
R
S
A
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Q
R
C
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A
L
R
L
L
F
V
Q
E
D
V
A
D
R
--
M
I
E
M
V
A
G
A
A
R
E
L
K
I
G
D
P
S
D
V
A
T
H
V
G
P
V
I
D
-
V
E
A
-
K
-
Q
R
L
D
A
H
I
A
R
M
K
T
E
A
---
R
L
H
F
A
G
P
A
P
E
G
C
F
V
A
-
P
H
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F
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L
T
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A
G
Q
L
T
--
E
E
V
F
G
P
I
L
H
V
V
R
Y
R
P
E
--
N
L
E
R
V
L
R
A
I
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R
T
G
Y
G
L
T
L
G
V
H
S
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I
D
D
S
I
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A
I
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D
R
V
Q
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N
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V
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N
M
I
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A
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V
G
V
Q
P
F
G
G
N
G
L
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--
G
T
G
P
K
A
G
G
P
H
Y
L
A
R
F
A
T
E
Q
T
V
T
I
N
T
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
84.20
25%
-49
- C3 -
3HAZ
13
?
A:
[34-986]
--
P
Q
--------
E
A
R
I
H
R
T
A
T
R
L
I
E
A
I
R
K
R
---
R
L
G
G
V
E
D
M
L
R
E
F
A
L
S
T
K
E
G
L
A
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L
A
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A
L
L
R
V
--
P
D
A
R
T
A
D
Q
F
I
E
D
K
L
G
E
G
D
F
I
H
H
E
T
K
S
T
A
F
L
V
NASA
W
A
A
R
V
I
-----------
Q
P
GE
T
P
D
G
------------------
T
I
G
R
L
V
K
R
L
G
A
P
A
-
V
R
T
A
T
R
Q
A
M
R
L
M
-----
G
N
H
F
V
L
G
E
T
I
E
Q
A
L
E
R
G
K
P
R
--
S
G
Q
K
T
R
Y
S
F
D
M
L
G
E
G
A
R
T
A
A
D
A
R
R
Y
F
D
A
Y
A
S
---
A
I
E
T
I
G
K
A
AGNHAL
P
D
R
P
G
---------------------
I
S
V
K
L
S
A
L
H
P
R
F
E
A
I
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R
A
R
V
M
V
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L
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Q
L
L
D
L
A
Q
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A
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A
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------
D
L
N
F
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A
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A
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L
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L
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A
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L
A
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L
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--
W
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----
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A
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A
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---
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---
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A
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I
A
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A
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---
L
L
A
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L
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R
L
L
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A
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V
A
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A
A
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P
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P
A
L
L
Q
R
P
A
D
A
--------------
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A
A
A
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C
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---
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T
A
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Q
----
L
L
T
-------------------------------------
D
V
K
A
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-
G
-
D
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L
K
P
I
A
D
A
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F
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---------------
A
A
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K
L
--------
F
----------
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A
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----
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--------
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P
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----
L
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--------
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R
PE
N
L
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V
L
R
A
I
E
R
T
G
Y
G
L
T
L
G
V
H
S
R
I
D
D
S
I
E
A
I
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V
Q
V
G
N
I
Y
V
N
R
N
M
I
G
A
V
V
G
V
Q
P
F
G
G
N
G
L
S
--
G
T
G
P
K
A
G
G
P
H
Y
L
A
R
F
A
T
E
Q
T
V
T
I
N
T
A
A
A
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
67.29
31%
-45
* C3 *
1UZB
5
?
A:
[4-512]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
-
F
R
N
E
P
I
E
T
F
Q
T
E
E
A
R
R
A
M
R
E
----
A
L
R
R
V
R
E
E
-
F
G
R
---------
H
Y
P
L
Y
I
G
G
E
W
V
D
T
-
K
E
R
M
V
S
L
N
P
S
A
P
S
-
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
---------------
A
R
A
A
-
L
R
Y
--------
R
----------
Y
P
A
V
E
V
V
P
Y
P
G
E
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
G
RLAPGQT
W
F
K
R
----
A
Y
--------
V
E
T
G
G
K
N
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
--
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
P
A
-
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
E
R
-
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
G
T
--
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
66.55
30%
-45
- C3 -
3QAN
-
ROCA1_BACHD
A:
[5-515]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
Y
K
H
E
P
F
T
D
F
T
V
E
A
N
R
K
A
F
E
E
----
A
L
G
L
V
E
K
E
-
L
G
K
---------
E
Y
P
L
I
I
N
G
E
R
V
T
T
-
E
D
K
I
Q
S
W
N
P
A
R
-
K
D
Q
L
V
G
S
V
S
K
A
N
Q
D
L
A
E
K
A
I
Q
S
A
D
E
A
F
Q
T
W
R
N
V
N
P
E
E
R
A
N
I
L
V
K
A
A
A
I
I
R
R
R
K
H
E
F
S
A
W
L
V
H
E
A
G
K
P
W
K
E
A
D
A
D
T
A
E
A
I
D
F
L
E
Y
Y
---------------
A
R
Q
M
-
I
E
L
--------
N
----------
R
G
K
E
I
L
S
R
P
G
E
-
Q
N
R
Y
F
--------
Y
T
P
M
G
V
T
V
T
I
S
--
P
W
N
F
A
L
A
I
M
V
G
T
A
V
A
P
I
V
T
G
N
T
V
V
L
K
P
A
S
T
T
P
V
V
A
A
K
F
V
E
V
L
E
D
A
G
L
P
K
G
V
I
N
Y
V
P
G
S
G
A
E
V
G
D
Y
L
V
D
H
P
K
T
S
L
I
T
F
T
G
S
K
D
V
G
V
R
L
Y
----
E
--------
R
A
A
VVRPGQ
N
--------
H
L
K
R
----
V
I
--------
V
E
M
G
G
K
D
T
V
V
V
D
R
D
A
D
L
D
L
A
A
E
S
I
L
V
S
A
F
G
F
S
G
Q
K
C
S
A
G
S
R
A
V
I
H
K
D
V
Y
D
--
E
V
L
E
K
T
V
A
L
A
K
N
L
T
V
G
D
P
T
N
R
D
N
Y
M
G
P
V
I
D
-
E
K
A
-
F
E
K
I
M
S
Y
I
E
I
G
K
K
E
G
R
---
L
M
T
G
G
E
G
D
S
S
T
G
F
F
I
Q
P
T
I
I
A
D
L
D
P
E
A
V
I
M
Q
E
E
I
F
G
P
V
V
A
F
S
K
--
A
N
--
D
F
D
H
A
L
E
I
A
N
N
T
E
Y
G
L
T
G
A
V
I
T
R
N
R
A
H
I
E
Q
A
K
R
E
F
H
V
G
N
L
Y
F
N
R
N
C
T
G
A
I
V
G
Y
H
P
F
G
G
F
K
M
S
G
--
T
D
S
K
A
G
G
P
D
Y
L
A
L
H
M
Q
A
K
T
V
S
E
M
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
64.70
34%
-48
- C3 -
2EHQ
10
?
B:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
ARAALRYRYPAVEVV
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QTWFKRAY
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
64.60
33%
-47
- C3 -
3QAN
1
ROCA1_BACHD
C:
[65-503]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
S
V
S
K
A
N
Q
D
L
A
E
K
A
I
Q
S
A
D
E
A
F
Q
T
W
R
N
V
N
P
E
E
R
A
N
I
L
V
K
A
A
A
I
I
R
R
R
K
H
E
F
S
A
W
L
V
H
E
A
G
K
P
W
K
E
A
D
A
D
T
A
E
A
I
D
F
L
E
Y
Y
---------------
A
R
Q
M
-
I
E
L
--------
N
RGKEILSRPG
E
Q
----------
N
R
Y
F
---------
Y
T
P
M
G
V
T
V
T
I
S
--
P
W
N
F
A
L
A
I
M
V
G
T
A
V
A
P
I
V
T
G
N
T
V
V
L
K
P
A
S
T
T
P
V
V
A
A
K
F
V
E
V
L
E
D
A
G
L
P
K
G
V
I
N
Y
V
P
G
S
G
A
E
V
G
D
Y
L
V
D
H
P
K
T
S
L
I
T
F
T
G
S
K
D
V
G
V
R
L
Y
----
E
RAAVVRPG
Q
--------
N
--------
H
L
K
R
----
V
I
--------
V
E
M
G
G
K
D
T
V
V
V
D
R
D
A
D
L
D
L
A
A
E
S
I
L
V
S
A
F
G
F
S
G
Q
K
C
S
A
G
S
R
A
V
I
H
K
D
V
Y
-
D
E
V
L
E
K
T
V
A
L
A
K
-
N
L
T
V
G
D
P
T
N
R
D
N
Y
M
G
P
V
I
D
E
K
A
F
-
E
-
K
I
M
S
Y
I
E
I
G
K
K
E
G
R
---
L
M
T
G
G
E
G
D
S
S
T
G
F
F
I
Q
P
T
I
I
A
D
L
D
P
E
A
V
I
M
Q
E
E
I
F
G
P
V
V
A
F
S
K
--
A
N
--
D
F
D
H
A
L
E
I
A
N
N
T
E
Y
G
L
T
G
A
V
I
T
R
N
R
A
H
I
E
Q
A
K
R
E
F
H
V
G
N
L
Y
F
N
R
N
C
T
G
A
I
V
G
Y
H
P
F
G
G
F
K
M
S
--
G
T
D
S
K
A
G
G
P
D
Y
L
A
L
H
M
Q
A
K
T
V
S
E
M
Y
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
64.60
35%
-45
- C3 -
1UZB
6
?
B:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
ARAALRYRYPAVEVV
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QTWFKRAY
V
E
T
G
G
K
N
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
64.49
34%
-47
- C3 -
2EIT
13
?
B:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
ARAALRYRYPAVEVV
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QTWFKRAY
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
64.48
34%
-47
- C3 -
2EJ6
12
?
B:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
ARAALRYRYPAVEVV
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QTWFKRAY
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
64.43
34%
-47
- C3 -
2IY6
12
?
B:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
ARAALRYRYPAVEVV
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QTWFKRAY
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
64.42
34%
-47
- C3 -
2IY6
11
?
A:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RYPA
V
E
V
V
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QT
W
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
64.41
34%
-48
- C3 -
2J5N
13
?
B:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
ARAALRYRYPAVEVV
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QTWFKRAY
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
64.40
34%
-48
- C3 -
2EJ6
11
?
A:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RYPA
V
E
V
V
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QT
W
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
64.39
35%
-47
- C3 -
2EIW
10
?
A:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RYPA
V
E
V
V
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QT
W
F
K
R
A
Y
V
E
T
G
G
K
N
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
64.30
34%
-45
- C3 -
2BHP
11
?
B:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
ARAALRYRYPAVEVV
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QTWFKRAY
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
64.28
34%
-47
- C3 -
2EJD
13
?
B:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
ARAALRYRYPAVEVV
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QTWFKRAY
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
64.27
34%
-45
- C3 -
2BJA
5
?
B:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
ARAALRYRYPAVEVV
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QTWFKRAY
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
64.26
34%
-47
- C3 -
2EJD
12
?
A:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RYPA
V
E
V
V
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QT
W
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
64.24
34%
-45
- C3 -
2BHQ
7
?
B:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
ARAALRYRYPAVEVV
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QTWFKRAY
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
64.22
34%
-47
- C3 -
2EJL
13
?
B:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
ARAALRYRYPAVEVV
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QTWFKRAY
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
64.18
34%
-47
- C3 -
2EIT
12
?
A:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RYPA
V
E
V
V
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QT
W
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
64.12
34%
-47
- C3 -
2EHU
16
?
B:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
ARAALRYRYPAVEVV
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QTWFKRAY
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
64.12
34%
-47
- C3 -
2EII
17
?
B:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
ARAALRYRYPAVEVV
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QTWFKRAY
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
64.12
35%
-47
- C3 -
2EIW
10
?
B:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
ARAALRYRYPAVEVV
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QTWFKRAY
V
E
T
G
G
K
N
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
64.11
34%
-48
- C3 -
2EHU
15
?
A:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RYPA
V
E
V
V
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QTWF
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
64.06
34%
-47
- C3 -
2BHQ
11
?
A:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RYPA
V
E
V
V
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QT
W
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
63.99
34%
-48
- C3 -
2J40
11
?
B:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
ARAALRYRYPAVEVV
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QTWFKRAY
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
63.97
34%
-46
- C3 -
2J5N
12
?
A:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RYPA
V
E
V
V
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QTWF
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
63.96
34%
-47
- C3 -
2BJK
9
?
A:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RYPA
V
E
V
V
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QT
W
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
63.84
34%
-47
- C3 -
2EJL
12
?
A:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RYPA
V
E
V
V
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QT
W
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
63.84
34%
-48
- C3 -
2EHQ
10
?
A:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RYPA
V
E
V
V
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QT
W
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
63.78
34%
-46
- C3 -
2BHP
14
?
A:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RYPA
V
E
V
V
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QT
W
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
63.76
34%
-47
- C3 -
2EII
15
?
A:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RYPA
V
E
V
V
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QT
W
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
63.43
34%
-47
- C3 -
2J40
10
?
A:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RYPA
V
E
V
V
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QT
W
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
63.28
34%
-45
- C3 -
2BJK
10
?
B:
[101-509]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
ARAALRYRYPAVEVV
P
Y
P
------------------------
G
E
----------
D
N
E
S
F
--------
Y
V
P
L
G
A
G
V
V
I
A
--
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
----
E
--------
A
--------
A
--------
G
R
L
A
----
P
G
QTWFKRAY
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
--
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
-
A
E
Q
-
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
---
L
V
L
G
G
K
R
L
E
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
--
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
P
F
G
G
F
K
L
S
--
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------