@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0061: (2015-12-12 )
MIEISEWLQKLDDALDKVVAKKEPESFLKPIISPIEDYQKSVRQIQAQFTDAPKFNEEGAYPQFLSCGLLQVRGKNGANMEFLLPKVYPFPPKSLYIEHEKDGQFLREMLMRLLSSAPLVQLEVILIDALSLGGIFNLARRLLDKNNDFIYQQRILTESKEIEEALKHLHEYLKVNLQEKLAGFRDFVHYNENAKDSLPLKALFLSGVDALSKDALYYLEKIMRFGSKNGVLSFVNLESEKNNQSAEDLKRYAEFFKDRTSFECLKYLNVEIISDQGIKSQHMQDFADKIKAYYKQKKEVKRELKDLQRDKEFWTKSSQHEVSVPVGWDINHKEVCFKIGNEQNHTLICDHSGSGKSNFLHVLIQNLAFYYDPDEVQLFLLDYKEGVEFNAYVADPALEHARLVSVASSISYGITFLKWLCDEMQKRADRFKQFNVKDLSDYRKHEKMPRLIVVIDEFQVLFSDNKSTKAVEGHLNTLLKKGRSYGVHLVLATQTMRGTDINPSFKAQIANRIALPMDAEDSSSVLGDDAACEIQKPEGIFNNNGGNRKYHTKMSVPKAPDDFKSFLTKIHAEFNQRNLAPIDRKIYNGETPLKMPDTLKANEMRLHLGKKVDYEQKDLIVEFESNESHLLVVIQDLNARIALMKLLFQNVKSANKELVFCNKEKRLIRSFDAQKEYGITPVENILSVLDTAMNPNSALVIDNLNEAKELHDKVGAEKLKSFLEKAIDNEQYCVIFAHDFRQIKTNYHFDKLKELLNNHFKQCLAFRCNGENLNAIKSDLPPPSKLNVLLIELSKDSVTEFRPFSL
Atome Classification :
(20 SA)
--.........10........20.--.......30........40..---------......50.....------...60........70........-80........90..--......100.....--..110......----.120.....-----..130.......140.......150--..-.......160.......170....--...180.--......-190....---....-.200....--...210---------------.--------.......220.......-230.......240-...----.....250.......260----------........270.-...-...280.....-----..---------290....-----------...300---------...----------......310--.--..---------..----....-320.----------------...--...330.--.....---.-----340........350..--...-..360.....---..370.......380......------.390.......400-------..----..-----.-.---...410.........420----.......430.-.----.....440.--.--------.----------------------------.-------.----------------------------..450....--...460.......470.------......480......--------------------..490...-----.-...500......----.510---...-.----..-..520-.----------........530...--....540.......550......---------.--560...----...----.570.......580.......590------.......---600.......610.......620.........630....-...640.......650..----..----...660.......670....---.------..680-------.-....-...690---------------------------------------------.---------------------------------------.....-----------..-----------------.700.--------......710.......720.......730.......740.......750.......---760.......-770........---.780........790.......800....---------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MI
E
I
S
E
W
L
Q
K
L
D
D
A
L
D
K
V
V
AKK--E
P
E
S
F
L
K
P
I
I
S
P
I
E
D
Y
Q
K
S
V
R
---------
Q
I
Q
A
QFTDAPKFN------EEGA
Y
P
Q
F
L
SC
G
L
L
Q
V
RGKNGAN-
M
E
F
L
LPKVYPFPPK--
S
L
Y
I
E
HEK
D
G
Q
F
L
R
--
E
M
L
M
R
L
LSSA
P
----
L
V
Q
L
E
V
I
L
I
-----
D
A
L
SLG
G
I
F
N
L
A
R
R
L
LDKNN
D
F
I
----
Y
Q
-
Q
R
ILT
E
S
K
E
I
E
E
A
L
K
H
L
H
E
Y
L
K
V
N
--
L
Q
E
K
L
A
G
--
F
R
D
F
V
H-Y--NENA---KDSL-
P
L
K
A
L
F
L
S
--
G
V
D
A
L
----------------
S
--------
K
D
A
L
Y
Y
L
E
K
I
M
R
FGSKN-G
V
L
S
F
V
N
LESEK--NNQ----
S
A
E
D
L
K
R
Y
A
E
F
F
KDRT
S
-----------
F
E
C
L
K
YL
N
V
E
I
I-SDQ-GI
K
S
Q
H
M
Q
D
F
A
-----
D
K
---------
I
K
A
Y
Y
K
Q
-----------
K
K
E
V
-----------
K
R
E
----------
L
K
D
L
Q
R
D
----
K
--
E
F---------WT----KSSQ-
H
E
V
S----------------VPV--GWDI
N
H
K
--
E
V
C
F
K---I-----G-NEQN
H
T
L
I
C
DHSGS--G
K
S
-
N
F
L
H
V
L
I
Q
N
L
---
A
F
Y
YDPD
E
V
Q
L
F
L
L
DYKEG
V
E
------
F
N
A
Y
VAD
P
A
L
E
H
---------
A
R
----
L
V
-----
S
-
V
---
A
S
S
I
--
S
Y
G
I
T
F
L
K
W
L
C
D
----
E
M
Q
K
R
A
D
R
F
KQ-F----
N
V
K
D
L
S
D
Y
R
--
K
--------
H
----------------------------E-------K----------------------------M
P
R
L
I
V
V
I
D
--
E
F
Q
V
LFSDNKST
K
A
V
E
G
------
H
L
N
T
L
L
KK-GRSY
G
V
--------------------
H
L
V
L
A
T
QT-----M-RGTDIN
P
S
F
K
A
Q
----
I
A
N----RIA-L----PM-DAE---D----------SSSVLGDDA
A
C
E
IQ--KPEGIFNNNGGN
R
K
Y
H
T
KMSVPK---------A--
P
D
D
F
K
S
----
F
L
T
----
K
I
H
A
E
FNQRNLAPIDRKIYNGETP------LKMPDTL---KAN
E
M
R
L
HLGKKVDYEQK
D
L
I
--
V
E
FESNE
S
H
L
L
V
V
I
QD-L
N
A
R
I
A
L
M
K
L
L
F
Q
N
V
K
SA----NK----
E
L
V
F
CN
K
E
K
R
L
I
R
S
FDAQKE---Y------GI
T
P
--------
V
-
E
N
I
L
-
S
V
L
D
-----------------------------------------------T---------------------------------------AMNPN-----------
S
A
-----------------
L
V
IDN--------
L
N
E
A
K
E
L
H
D
K
V
G
A
E
K
L
K
S
F
L
E
K
AIDNE
Q
Y
C
V
I
F
A
H
D
F
R
Q
I
KTNY
H
F
D
K
L
K
E
L
L
N
N
H
---
F
K
Q
C
L
A
FRCN-G--EN
L
N
A
I
KS---DLP-PPSK
L
N
V
L
L
I
ELSKDSVTEFRPFSL---------
36
Fugue
81.39
16%
-51
- C2 -
4NH0
5
?
A:
[246-1147]
SA
N
M
T
L
T
S
L
L
H
I
D
N
P
Y
N
L
D
P
A
V
L
W
--
R
P
R
P
Q
R
N
R
L
R
V
P
I
-
G
L
D
A
D
G
R
---------
P
L
E
L
D
I
K
E
S
A
Q
---------
G
G
M
G
P
H
G
L
C
I
G
A
T
G
-
S
G
K
S
E
L
L
-
R
T
L
V
L
A
L
A
M
T
H
S
P
E
V
L
N
F
V
L
V
D
F
K
G
G
A
T
F
L
GM
E
G
L
R
H
V
S
A
I
I
T
----
N
L
E
E
E
L
P
L
V
-----
D
R
M
Y
D
A
L
H
G
E
M
V
R
R
Q
E
H
L
R
H
S
G
N
----
Y
A
S
L
R
D
Y
E
K
A
R
M
E
G
A
P
L
P
P
M
P
T
L
F
I
V
L
D
E
F
S
E
L
L
S
A
--
K
P
D
F
A
E
L
F
--
V
M
I
G
---
R
L
G
R
-
S
L
G
V
H
L
L
L
--
A
S
Q
R
L
----------------
E
--------
E
G
K
L
R
G
L
D
T
H
L
S
Y
--
R
I
-
G
L
R
T
F
S
A
M
E
S
R
V
V
L
G
V
P
----
D
A
Y
E
L
P
P
S
P
G
N
G
Y
L
K
F
A
-----------
T
E
P
L
V
R
F
K
A
A
Y
V
-
S
---
G
P
V
D
E
E
S
E
S
L
F
-----
D
V
---------
V
V
R
Q
L
A
G
-----------
H
G
P
E
-----------
P
H
Q
----------
I
W
L
P
P
L
D
----
V
--
P
P
T
L
D
E
L
L
PP-
L
S
----
P
S
A
A
-
H
G
Y
T
ADGWEWRGRL
H
A
V
V
GL
V
D
R
--
P
F
D
Q
R
R
D
--
P
Y
W
L
D
---
L
-----
S
-
G
G
A
G
H
V
G
V
A
G
G
P
Q
T
--
G
K
S
-
T
M
L
R
T
L
I
T
S
L
---
A
L
L
H
T
P
Q
E
V
Q
F
Y
C
L
D
F
G
G
G
----------
T
L
A
G
L
A
E
L
P
H
---------
V
G
----
S
V
-----
A
-
T
---
R
L
D
A
--
D
R
I
R
R
T
V
A
E
V
S
A
----
L
L
E
Q
R
E
Q
E
F
T
E
-
R
----
G
I
D
S
M
A
T
Y
R
--
R
--------
L
----------------------------
R
-------
A
T
GEYAGDG--------------------
F
G
D
V
F
L
V
V
D
--
N
W
L
T
L
R
Q
D
Y
E
---
A
L
E
D
------
S
I
T
Q
L
A
A
R
-
G
L
G
Y
G
I
--------------------
H
V
V
L
S
S
N
--------
K
W
S
E
F
R
T
S
I
R
D
L
----
L
G
T
----
K
L
E
-
L
----
R
L
-
G
D
P
---
Y
----------
E
S
E
V
D
R
K
K
A
A
N
V
P
E
--
N
R
P
G
R
G
L
T
R
D
G
---
Y
H
F
L
T
A
L
P
R
IDGDTSAET
L
--
T
E
G
I
A
T
----
T
V
K
----
T
I
R
E
A
W
H
G
P
T
A
P
P
V
-
R
M
L
P
N
V
L
P
A
------
A
Q
L
P
S
A
A
---
E
S
G
T
-
R
I
P
I
G
I
D
E
D
-
S
L
S
P
V
Y
--
L
D
F
N
T
D
-
P
H
F
L
V
F
G
D
T
-
E
C
G
K
S
N
L
L
R
L
I
T
A
G
I
I
E
R
----
Y
T
PQQ
A
R
L
I
F
I
D
Y
S
R
S
L
L
D
V
A
T
T
E
H
Q
---
I
------
G
Y
A
A
S
S
T
A
A
S
S
L
V
-
R
D
I
K
-
G
A
M
E
-----------------------------------------------
A
---------------------------------------
R
L
P
P
P
-----------
D
L
T
P
E
Q
L
R
S
RSW
W
T
G
A
E
L
F
L
V
V
D
D
--------
Y
E
M
V
A
T
S
D
N
P
L
--
R
P
L
A
E
L
L
P
Q
A
R
D
I
-
G
L
H
L
I
I
A
R
S
M
G
G
A
G
R
A
L
Y
E
P
I
I
Q
R
I
K
E
M
A
---
S
P
-
G
L
V
M
S
G
N
-
K
--
D
E
G
I
L
L
G
N
---
V
K
P
-
H
K
L
P
Q
G
R
G
Y
F
V
E
R
R
S
G
T
R
L
I
Q
T
A
Y
R
E
S-------
37
Fugue
80.18
21%
-67
- C2 -
2IUT
3
FTSK_PSEAE
A:
[70-477]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-
P
L
S
L
L
D
P
A
E
V
K
Q
--
K
S
Y
----
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
-
P
A
A
-
G
V
K
V
S
R
I
S
N
L
A
-----
K
D
---------
L
A
R
S
L
A
V
I
S
V
R
V
V
EVIPG
K
T
T
V
-----------
G
I
E
----------
I
P
N
E
D
R
Q
M
V
R
F
S
--
E
V
---------
L
S
S
P
E
Y
D
E
H
K
-
S
T
V
P
----------------
L
A
L
--
G
H
D
I
G
G
R
--
P
I
I
T
D
---
L
-----
A
-
K
-
M
P
H
L
L
V
A
G
T
T
G
S
--
G
K
S
-
V
G
V
N
A
M
L
L
S
I
---
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
-
L
E
------
L
S
I
Y
E
G
I
P
H
L
-----------------
L
C
-----
P
-
V
---
V
T
D
M
--
K
E
A
A
N
A
L
R
W
S
V
A
----
E
M
E
R
R
Y
R
L
M
A
A
-
M
----
G
V
R
N
L
A
G
F
N
--
R
--------
K
V
K
D
A
E
E
A
G
T
P
L
T
DPLFRRESPDDEPPQL
S
-------
T
----------------------------
L
P
T
I
V
V
V
V
D
--
E
F
A
D
M
M
M
I
V
G
--
K
K
V
E
E
------
L
I
A
R
I
A
Q
K
-
A
R
A
A
G
I
--------------------
H
L
I
L
A
T
Q
R
-----
P
-
S
V
D
V
I
T
G
L
I
K
A
N
----
I
P
T
----
R
I
A
-
F
----
Q
V
S
S
K
I
---
D
----------
S
R
T
I
L
D
Q
G
G
A
E
Q
L
L
--
G
H
G
D
M
L
Y
L
P
P
G
T
G
L
P
I
R
V
H
G
A
F
V
---------
S
--
D
D
E
V
H
R
----
V
V
E
----
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
77.72
26%
-85
- C2 -
2IUS
-
FTSK_ECOLI
A:
[962-1224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
L
T
----------------
V
V
L
--
G
K
D
I
A
G
E
--
P
V
V
A
D
---
L
-----
A
-
K
-
M
P
H
L
L
V
A
G
T
T
G
S
--
G
A
S
-
V
G
V
N
A
M
I
L
S
M
---
L
Y
K
A
Q
P
E
D
V
R
F
I
M
I
D
P
K
M
L
-
E
------
L
S
V
Y
E
G
---
I
P
H
---------
L
L
----
T
------
E
-
V
---
V
T
D
M
--
K
D
A
A
N
A
L
R
W
C
V
N
----
E
M
E
R
R
Y
K
L
M
S
A
-
L
----
G
V
R
N
L
A
G
Y
N
--
E
--------
K
I
A
E
A
D
R
M
MRPIPDPYWH
P
V
L
--------
K
-------
K
----------------------------
E
P
Y
I
V
V
L
V
D
--
E
F
A
D
L
M
M
T
V
G
--
K
K
V
E
E
------
L
I
A
R
L
A
Q
K
-
A
R
A
A
G
I
--------------------
H
L
V
L
A
T
Q
R
-----
P
-
S
V
D
V
I
T
G
L
I
K
A
N
----
I
P
T
----
R
I
A
-
F
----
T
V
-
S
S
K
I
--
D
----------
S
R
T
I
L
D
Q
A
G
A
E
S
L
L
G-
M
G
D
M
L
Y
S
G
P
N
S
T
L
--
P
V
R
V
H
G
A
F
---------
V
--
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
76.70
23%
-68
- C2 -
2IUT
3
FTSK_PSEAE
A:
[122-453]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
E
I
Q
-
P
A
A
-
G
V
K
V
S
R
I
S
N
L
A
-----
K
D
---------
L
A
R
S
L
A
V
-----------
I
S
V
R
V
V
EVIPGKT
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
----
P
---
E
---------
Y
D
-----
E
H
K
-
S
T
V
P
----------------
L
A
L
--
G
H
D
I
G
G
R
--
P
I
I
T
D
---
L
-----
A
-
K
-
M
P
H
L
L
V
A
G
T
T
G
S
--
G
K
S
-
V
G
V
N
A
M
L
L
S
I
---
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
-
E
------
L
S
I
Y
E
G
---
I
P
H
---------
L
L
----
C
------
P
-
V
---
V
T
D
M
--
K
E
A
A
N
A
L
R
W
S
V
A
----
E
M
E
R
R
Y
R
L
M
A
A
-
M
----
G
V
R
N
L
A
G
F
N
--
R
--------
K
V
K
D
A
E
E
A
G
T
P
L
T
DPLFRRESPDDEPPQL
S
-------
T
----------------------------
L
P
T
I
V
V
V
V
D
--
E
F
A
D
M
M
M
I
V
G
--
K
K
V
E
E
------
L
I
A
R
I
A
Q
K
-
A
R
A
A
G
I
--------------------
H
L
I
L
A
T
Q
R
-----
P
-
S
V
D
V
I
T
G
L
I
K
A
N
----
I
P
T
----
R
I
A
-
F
----
Q
V
-
S
S
K
I
--
D
----------
S
R
T
I
L
D
Q
G
G
A
E
Q
L
L
G-
H
G
D
M
L
Y
L
P
P
G
T
G
L
--
P
I
R
V
H
G
A
F
---------
V
--
S
D
D
E
V
H
----
R
V
V
----
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
74.65
16%
-25
* C3 *
2IPC
-
SECA_THET8
A:
[1-939]
--
M
L
G
L
L
R
R
L
F
D
N
N
E
R
E
I
A
R
Y
Y
K
Q
V
V
E
P
V
N
R
L
E
A
E
V
E
K
L
P
D
L
A
A
A
Y
R
---------
E
L
K
E
K
H
E
K
G
A
--
S
------
L
D
E
L
L
P
M
A
F
A
L
T
R
E
S
A
K
R
Y
L
G
M
R
H
F
D
V
Q
L
I
G
G
A
V
L
H
E
G
--
K
I
A
E
M
K
T
G
E
G
K
T
L
V
--
A
T
L
A
V
A
L
N
A
L
T
----
G
K
G
V
H
V
V
T
V
-----
N
-------
D
Y
L
A
R
R
D
A
E
W
M
G
P
V
Y
R
G
L
G
L
S
-
V
G
V
I
Q
H
A
S
T
P
A
E
R
R
K
A
Y
L
A
D
V
T
Y
V
--
T
N
S
E
L
G
F
D
Y
L
R
D
N
M
A
-
I
--
S
P
D
Q
LVL
R
H
D
H
-
P
L
H
Y
A
I
I
D
--
E
V
D
S
I
LIDEAR
T
P
L
I
I
S
G
P
AE
K
--------
A
T
D
L
Y
Y
K
M
A
E
I
A
K
K
L
E
R
-
G
L
P
A
E
P
G
V
R
K
E
P
--
T
G
D
----
Y
T
V
E
E
K
N
R
S
V
H
L
T
L
Q
G
I
-----------
A
K
A
E
K
L
L
G
I
E
G
L
F
S
P
E
-
N
M
E
L
A
H
M
L
I
Q
A
-----
I
R
---------
A
K
E
L
Y
H
R
-----------
D
R
D
Y
-----------
I
V
Q
----------
D
G
Q
V
I
I
V
----
D
--
E
F
TGRLMPG
R
R
Y
G
----
E
G
L
H
-
Q
A
I
E
----------------
A
K
E
--
G
V
R
I
E
R
E
--
N
Q
T
L
A
---
T
-----
I
-
T
Y
Q
N
F
F
R
L
Y
E
K
R
A
G
M
T
G
T
A
-
K
T
E
E
K
E
F
Q
E
I
YG
M
D
V
V
V
V
P
T
N
R
P
V
I
R
K
D
F
P
D
V
V
Y
RT
E
K
G
K
F
Y
A
V
V
E
E
I
A
E
K
Y
---------
E
R
G
Q
P
V
L
V
G
T
IS
I
E
-
K
---
S
E
R
L
--
S
Q
M
L
K
E
P
R
L
Y
L
P
----
R
L
E
M
R
L
E
L
F
K
K
-
A
S
QKQ
Q
G
P
E
W
E
R
L
R
--
K
--------
L
----------------------------
L
-------
E
----------------------------
R
P
A
Q
L
K
D
E
D
LA
P
F
E
G
L
I
P
P
K
G
N
L
R
T
A
W
E
G
L
K
R
A
V
H
T
L
A
V
L
R
Q
-
G
I
P
H
Q
V
L
NAKH
H
A
R
E
A
E
I
V
A
Q
AGRSK
T
V
T
I
A
T
N
M
-----
A
G
R
G
T
D
I
K
L
G
G
N
P
E
----
Y
L
A
----
A
A
L
-
L
----
E
K
-
E
G
F
---
D
RYEWK
V
E
L
F
I
K
K
M
V
A
G
K
E
E
E
A
R
A
L
--
A
Q
E
L
G
I
R
E
E
L
L
E
R
I
R
E
I
R
E
E
C
K
Q
---------
D
--
E
E
R
V
R
A
L
GGL
F
I
I
----
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
A
G
R
Q
G
D
P
G
G
S
R
F
Y
V
S
F
D
D
D
L
MRL
F
A
S
D
R
V
I
A
M
L
D
R
M
G
F
D
D
S
E
P
I
E
H
P
M
V
T
R
S
I
E
R
A
Q
K
R
V
E
D
-
R
N
F
A
I
R
K
Q
L
L
Q
F
D
D
V
L
S
R
----
Q
R
----
E
V
I
Y
A
Q
R
R
L
I
L
L
G
K
D
E
E
V
K
E
---
A
------
A
I
G
M
--------
V
E
E
T
V
A
-
S
L
A
E
-----------------------------------------------
N
---------------------------------------
F
L
N
P
E
VHPEDWD
L
E
G
L
K
A
-----------------
T
L
L
D
T
A
P
Q
L
Q
D
F
P
F
A
E
L
R
A
L
K
A
E
E
A
V
E
R
L
V
E
A
A
L
K
A
Y
E
A
R
E
A
E
-
L
S
P
P
L
M
R
A
V
E
R
F
V
I
L
N
V
V
D
N
A
W
K
E
H
---
L
H
N
L
D
V
L
R
Q
G
-
I
--
F
L
R
G
Y
G
Q
K
---
D
---
P
F
Q
E
Y
K
I
E
A
T
R
L
F
N
E
M
V
A
F
I
K
S
E
V
A
K
F
L
F
R
LKVE
3
PsiBlast_PDB
74.42
25%
-104
- C2 -
2IUS
-
FTSK_ECOLI
A:
[964-1196]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
----------------
V
V
L
--
G
K
D
I
A
G
E
--
P
V
V
A
D
---
L
-----
A
--
K
M
P
H
L
L
V
A
G
T
T
G
S
--
G
A
S
-
V
G
V
N
A
M
I
L
S
M
---
L
Y
K
A
Q
P
E
D
V
R
F
I
M
I
D
P
K
M
-
L
E
------
L
S
V
Y
E
G
I
P
H
L
-----------------
L
T
-----
E
-
V
---
V
T
D
M
--
K
D
A
A
N
A
L
R
W
C
V
N
----
E
M
E
R
R
Y
K
L
M
S
A
-
L
----
G
V
R
N
L
A
G
Y
N
--
E
--------
K
I
A
E
A
D
R
M
MRPIPDPYWH
P
V
L
--------
K
-------
K
----------------------------
E
P
Y
I
V
V
L
V
D
--
E
F
A
D
L
M
M
--
T
V
G
K
K
V
E
E
------
L
I
A
R
L
A
Q
K
-
A
R
A
A
G
I
--------------------
H
L
V
L
A
T
Q
R
-----
P
-
S
V
D
V
I
T
G
L
I
K
A
N
----
I
P
T
----
R
I
A
-
F
----
T
V
-
S
S
K
---
I
----------
D
S
R
T
I
L
D
Q
A
G
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
72.34
24%
-108
- C2 -
2IUU
1
FTSK_PSEAE
A:
[189-425]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
H
K
S
T
----------------
V
P
L
AL
G
H
D
I
G
G
R
--
P
I
I
T
D
---
L
-----
A
--
K
M
P
H
L
L
V
A
G
T
T
G
S
--
G
K
S
-
V
G
V
N
A
M
L
L
S
I
---
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
-
L
E
------
L
S
I
Y
E
G
I
P
H
L
-----------------
L
C
-----
P
-
V
---
V
T
D
M
--
K
E
A
A
N
A
L
R
W
S
V
A
----
E
M
E
R
R
Y
R
L
M
A
A
-
M
----
G
V
R
N
L
A
G
F
N
--
R
--------
K
----------------------------
V
-------
K
D
A
E
E
A
G
T
P
L
T
DPLFRRESPDD
E
P
P
Q
L
S
T
L
P
T
I
V
V
V
V
D
--
E
F
A
D
M
M
--
M
I
V
G
K
K
V
E
E
------
L
I
A
R
I
A
Q
K
-
A
R
A
A
G
I
--------------------
H
L
I
L
A
T
Q
R
-----
P
-
S
V
D
V
I
T
G
L
I
K
A
N
----
I
P
T
----
R
I
A
-
F
----
Q
V
-
S
S
K
---
I
----------
D
S
R
T
I
L
D
Q
G
G
A
E
Q
L
--
L
G
H
G
D
M
L
Y
L
P
P
G
T
G
L
P
I
R
V
H
G
A
F
---------
V
--
S
D
D
E
V
H
----
R
V
V
----
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
72.10
24%
-108
* C2 *
2IUT
2
FTSK_PSEAE
A:
[189-425]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
H
K
S
T
----------------
V
P
L
AL
G
H
D
I
G
G
R
--
P
I
I
T
D
---
L
-----
A
--
K
M
P
H
L
L
V
A
G
T
T
G
S
--
G
K
S
-
V
G
V
N
A
M
L
L
S
I
---
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
-
L
E
------
L
S
I
Y
E
G
I
P
H
L
-----------------
L
C
-----
P
-
V
---
V
T
D
M
--
K
E
A
A
N
A
L
R
W
S
V
A
----
E
M
E
R
R
Y
R
L
M
A
A
-
M
----
G
V
R
N
L
A
G
F
N
--
R
--------
K
----------------------------
V
-------
K
D
A
E
E
A
G
T
P
L
T
DPLFRRESPDDEPPQL
S
T
L
P
T
I
V
V
V
V
D
--
E
F
A
D
M
M
--
M
I
V
G
K
K
V
E
E
------
L
I
A
R
I
A
Q
K
-
A
R
A
A
G
I
--------------------
H
L
I
L
A
T
Q
R
-----
P
-
S
V
D
V
I
T
G
L
I
K
A
N
----
I
P
T
----
R
I
A
-
F
----
Q
V
-
S
S
K
---
I
----------
D
S
R
T
I
L
D
Q
G
G
A
E
Q
L
--
L
G
H
G
D
M
L
Y
L
P
P
G
T
G
L
P
I
R
V
H
G
A
F
---------
V
--
S
D
D
E
V
H
----
R
V
V
----
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
70.93
15%
-17
- C1 -
3UGM
-
PTHX1_XANOP
A:
[169-1048]
--
K
P
K
V
R
E
L
V
A
H
I
V
A
L
S
Q
H
P
A
A
L
G
--
T
V
A
V
T
Y
Q
H
I
I
T
A
L
A
T
H
E
D
I
V
G
V
G
KQWSG
A
R
A
L
E
A
L
L
T
D
A
G
E
L
R
GPPLQL
D
T
G
Q
L
V
K
I
A
K
R
G
G
V
T
A
M
E
A
V
H
A
S
-
R
N
A
L
T
P
L
N
L
T
-
P
A
Q
--
V
V
A
I
A
S
N
N
G
G
K
Q
A
L
--
E
T
V
Q
R
L
L
P
V
L
C
Q
A
HG
L
T
P
A
Q
V
V
A
I
A
SHDG
G
K
Q
A
L
E
T
M
Q
R
L
L
P
V
L
C
Q
A
H
G
L
P
P
----
D
Q
-
V
V
A
I
A
S
N
I
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
--
C
Q
A
H
G
L
T
--
P
D
Q
V
V
A
-
I
A
S
H
G
G
G
---
K
Q
A
L
-
E
T
V
Q
R
L
L
P
--
V
L
C
Q
A
----------------
H
--------
G
L
T
P
D
Q
V
V
A
I
A
S
H
D
G
G
K
-
Q
A
L
E
T
V
Q
R
L
L
P
V
--
L
C
Q
AHGL
T
P
D
Q
V
V
A
I
A
S
N
G
G
G
K
Q
A
-----------
L
E
T
V
Q
R
L
L
P
V
L
C
-
Q
A
H
-
G
L
T
P
D
Q
V
V
A
I
A
-----
S
N
GG-------
K
Q
A
L
E
T
V
-----------
Q
R
L
L
-----------
P
V
L
----------
C
Q
A
H
G
L
T
----
P
--
D
Q
---------
V
V
----
A
I
A
S
-
H
D
G
G
----------------
K
Q
A
--
L
E
T
V
Q
R
L
L
P
V
L
C
Q
T
---
H
-----
G
L
T
P
A
Q
V
V
A
I
A
S
H
D
G
G
--
K
Q
A
L
E
T
V
Q
Q
L
L
P
V
L
---
C
Q
A
H
G
L
T
P
D
Q
V
V
A
I
A
S
N
I
G
G
K
------
Q
A
L
A
T
V
Q
R
L
L
P
V
LCQAHGLTP
D
Q
----
V
V
-----
A
-
I
---
A
S
N
G
GG
K
Q
A
L
E
T
V
Q
R
L
L
P
----
V
L
C
Q
-
A
H
G
L
T
P
-
D
----
Q
V
V
A
I
A
--
S
--
N
--------
G
----------------------------
G
-------
G
----------------------------
K
Q
A
L
E
T
V
Q
R
--
L
L
P
V
L
C
Q
A
H
G
L
T
Q
V
Q
V
V
------
A
I
A
S
N
I
G
G
-
K
Q
A
L
E
T
--------------------
V
Q
R
L
L
P
V
L
-----
C
-
Q
A
H
G
L
T
P
A
Q
V
V
A
----
I
A
S
HDG
G
K
Q
A
-
L
----
E
T
-
V
Q
R
---
L
----------
L
P
-
V
L
C
Q
A
H
G
L
T
P
D
--
Q
V
V
A
I
A
S
N
G
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
---------
G
LT
Q
E
Q
V
V
A
----
I
A
S
NNGG
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
--
H
G
L
T
P
------
D
Q
V
V
A
I
A
---
S
-
N
G
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
--
Q
A
H
G
L
T
P
A
Q
V
V
A
I
A
S
N
-
I
G
G
K
Q
A
L
E
T
V
Q
-
R
L
L
P
V
L
----
C
Q
----
D
H
G
L
T
L
A
Q
V
V
A
I
A
S
N
I
G
G
K
Q
----------
A
L
E
T
--------
V
-
Q
R
L
L
-
P
V
L
C
-----------------------------------------------
Q
---------------------------------------
G
L
T
Q
D
-----------
Q
V
-----------------
V
A
I
A
S
--------
N
I
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
D
H
G
L
T
P
D
Q
V
V
A
I
A
S
N
I
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
D
H
GLT
L
D
Q
V
V
A
I
A
S
N
-
G
GK
Q
A
L
E
T
V
Q
R
---
L
L
P
-
V
L
C
Q
D
H
----
G
L
T
P
D
Q
V
V
A
I
A
S
N
S
G
---------
4
PsiBlast_PDB
68.42
28%
-66
- C2 -
4NH0
1
?
A:
[268-504]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------
W
R
----
P
R
P
Q
R
N
R
L
R
----------------
V
P
I
--
G
L
D
A
D
G
R
--
P
L
E
L
D
---
I
KESAQ
G
-
G
M
G
P
H
G
L
C
I
G
A
T
G
S
--
G
K
S
-
E
L
L
R
T
L
V
L
A
L
---
A
M
T
H
S
P
E
V
L
N
F
V
L
V
D
F
K
G
G
A
T
------
F
L
------
G
M
E
G
---------
L
R
----
H
V
-----
S
A
I
---
I
T
N
L
--
E
E
E
L
P
L
V
D
R
M
Y
D
A
L
H
G
E
M
V
R
R
Q
E
H
L
R
H
S
G
----
N
Y
A
S
L
R
D
Y
E
--
K
--------
A
----------------------------
R
M
E
G
A
P
L
P
P
----------------------------
M
P
T
L
F
I
V
L
D
--
E
F
S
E
L
L
----
S
A
K
P
D
F
A
------
E
L
F
V
M
I
G
R
L
G
R
S
L
G
V
--------------------
H
L
L
L
A
S
Q
R
LEEGK
L
-
R
G
L
D
T
H
L
S
Y
R
I
G
----
L
R
T
--------------
F
-
S
A
M
---
E
----------
S
R
V
V
L
G
V
P
D
A
Y
E
L
P
--
P
S
P
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
58.63
22%
-94
- C2 -
4LYA
1
?
A:
[73-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
G
N
I
G
I
F
G
S
A
G
Y
--
G
K
S
-
T
T
M
M
T
L
L
L
S
F
---
A
G
A
Y
N
P
A
Q
L
H
Y
Y
I
F
D
F
G
N
S
A
L
------
L
P
L
R
Q
L
P
H
T
A
D
Y
---------
F
R
----
L
D
-----
D
-----
E
K
K
I
--
E
---
K
F
I
K
F
M
K
E
----
E
M
E
Q
R
K
Q
R
F
M
E
-
K
----
E
V
S
T
I
K
L
Y
N
A
L
S
--------
E
----------------------------
E
-------
K
----------------------------
L
P
I
I
I
V
A
L
D
--
N
F
D
V
V
---
K
E
E
M
P
D
F
E
T
------
Q
L
I
Q
Y
A
R
D
-
G
Q
S
L
G
I
--------------------
F
F
I
M
T
A
T
R
-----
V
-
S
G
--
I
R
P
P
L
M
N
N
----
L
K
T
----
K
I
V
H
Y
----
F
I
-
D
S
S
---
E
----------
K
F
S
L
I
G
R
T
P
Y
D
V
D
P
--
I
P
G
R
A
L
I
K
K
D
N
A
A
L
T
Q
I
Y
L
P
A
D
G
---------
E
--
D
D
I
E
V
L
----
E
N
V
----
K
R
E
M
E
R
L
K
E
V
Y
Q
H
I
P
K
P
K
P
I
P
M
L
P
------
P
R
L
S
M
S
V
---
F
T
N
T
Y
V
Q
H
R
A
S
G
F
I
P
V
G
L
D
E
Q
--
T
V
R
P
V
A
I
N
M
R
T
D
P
H
C
L
-
I
V
G
Q
S
R
K
G
K
T
N
V
V
K
V
I
L
E
----
S
L
----
L
V
Q
E
P
E
S
I
G
L
L
D
G
I
D
R
G
L
A
G
---
Y
------
A
N
R
D
--------
D
-
I
T
Y
I
-
E
A
K
E
-----------------------------------------------
R
---------------------------------------
L
A
Q
W
L
-----------
N
E
-----------------
A
D
A
V
L
--------
Q
Q
R
E
R
E
Y
I
Q
A
V
N
W
P
P
V
V
F
V
V
D
S
L
L
R
L
Q
Q
E
T
D
S
I
M
Q
G
R
I
A
N
M
M
K
Q
Y
S
H
L
G
F
H
V
F
V
A
G
---
N
A
N
E
F
V
K
G
F
D
-
A
--
L
T
A
E
L
K
Q
I
---
R
Q
A
-
I
L
V
T
K
K
S
E
Q
S
L
F
A
L
P
F
T
R
N
E
Q
E
I
E
P
---------
38
Fugue
55.69
15%
-43
- C2 -
4KFU
6
?
A:
[2-206]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
D
D
I
V
V
L
V
G
R
K
K
S
--
G
K
S
-
Y
L
I
K
H
Y
F
I
P
V
---
L
K
A
H
K
I
----
S
Y
I
I
D
D
H
N
L
L
R
------
S
G
S
E
Y
S
K
F
G
Y
N
-----------------
A
-----
T
-
S
---
L
S
D
I
--
V
S
K
Q
Y
V
V
V
Y
D
R
A
----
K
N
D
D
F
F
E
K
L
W
Q
-
A
----
S
K
L
H
S
K
K
Y
G
--
T
-----------------------------------------------------------------------------
T
V
L
I
I
D
--
E
A
Y
Y
H
F
K
Y
K
Q
K
V
T
---
P
------
A
I
D
E
A
L
H
A
-
N
R
H
A
G
L
--------------------
G
L
I
L
S
T
Q
--------
R
V
Y
D
L
M
P
I
V
Y
K
Q
AD
L
I
I
M
F
----
Y
T
R
-
E
----
P
N
-
E
L
R
---
W
----------
I
S
K
Y
I
S
A
E
A
A
E
K
V
K
T
L
K
Q
Y
H
F
L
I
Y
D
V
N
S
Q
T
I
K
I
H
K
P
I
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
55.30
26%
-108
- C2 -
4N1A
2
?
A:
[109-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
G
K
S
-
T
M
L
R
T
L
I
T
S
L
---
A
L
L
H
T
P
Q
E
V
Q
F
Y
C
L
D
F
G
G
G
T
L
--------
A
G
L
A
E
--
L
P
H
---------
V
G
----
S
V
-----
A
-
T
RLD
A
D
R
I
--
R
R
T
V
A
E
V
S
A
L
-------
L
E
Q
R
E
Q
E
F
T
E
-
R
----
G
I
D
S
M
A
T
Y
R
--
R
L
R
A
T
GEYA
G
----------------------------
D
-------
G
----------------------------
F
G
D
V
F
L
V
V
D
--
N
W
L
T
L
R
Q
D
Y
---
E
A
L
E
D
------
S
I
T
Q
L
A
A
R
-
G
L
G
Y
G
I
--------------------
H
V
V
L
S
S
N
K
-----
W
-
S
E
F
R
T
S
I
R
D
L
L
G
----
T
K
L
----
E
L
R
-
L
----
G
D
-
P
Y
E
---
S
----------
E
V
D
R
K
K
A
A
N
V
P
E
N
R
--
P
G
R
G
L
T
R
D
G
Y
H
F
L
T
A
L
P
R
I
D
G
D
T
---------
S
--
A
E
T
L
T
E
----
G
I
A
----
T
T
V
K
T
I
R
E
A
W
H
G
P
T
A
P
P
V
R
M
L
P
N
V
------
L
P
A
A
Q
L
P
---
S
A
A
E
S
G
T
R
I
P
I
G
I
D
E
D
S
L
S
P
V
--
Y
L
D
F
N
T
D
P
H
F
L
V
F
G
D
T
-
E
C
G
K
S
N
L
L
R
L
I
T
A
G
I
I
E
R
----
Y
T
----
P
Q
Q
A
R
L
I
F
I
D
Y
S
R
S
L
L
D
V
A
T
---
T
------
E
H
Q
I
--------
G
-
Y
A
A
S
-
S
T
A
A
-----------------------------------------------
S
---------------------------------------
S
L
V
R
D
-----------
I
K
-----------------
G
A
M
E
A
--------
R
L
P
P
P
D
L
T
P
E
Q
L
R
S
R
S
W
W
T
G
A
E
L
F
L
V
V
D
D
Y
E
M
V
A
T
S
D
N
P
L
R
P
L
A
E
L
L
P
Q
A
R
D
I
G
L
H
---
L
I
I
A
R
S
M
G
G
A
-
G
--
R
A
L
Y
E
P
I
I
---
Q
R
I
-
K
E
M
A
S
P
G
L
V
M
S
G
N
K
D
E
G
I
L
L
G
N
V
K
P
---------
16
HHSearch
50.17
12%
-69
- C2 -
2IUT
2
FTSK_PSEAE
A:
[194-440]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
A
L
G
H
D
I
G
G
R
P
I
I
--
T
D
L
A
K
-
M
P
H
L
L
V
A
G
T
T
-
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
STPS
E
A
----
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
LLC
P
VVTD
M
K
E
A
A
N
--------
A
-
L
R
W
S
V
A
E
M
E
R
R
Y
R
L
M
A
A
M
GVRN
L
A
G
F
N
R
K
V
K
D
A
E
E
A
G
T
P
L
T
DPLFRRESPDDEPPQ
L
---------------------------------------
S
T
L
P
T
-----------
I
V
-----------------
V
V
V
D
E
--------
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
-------
D
V
I
T
G
L
I
K
A
N
---
I
P
T
R
I
A
F
Q
V
S
S
K
--
I
D
S
R
T
I
L
D
QG-
G
A
E
Q
L
L
G
H
G
D
M
L
Y
L
P
P
G
T
G
L
P
I
R
V
H
G
A
F
V
---------
41
Fugue
49.91
10%
-12
* C4 *
1LDJ
-
CUL1_HUMAN
A:
[1-760]
-----
L
D
Q
I
W
D
D
L
R
A
G
I
Q
Q
V
Y
T
R
Q
--
S
M
A
------
K
S
R
Y
M
E
L
Y
T
H
V
Y
---------
N
Y
C
T
S
V
G
L
E
L
Y
K
R
------
L
K
E
F
L
K
N
Y
L
T
N
L
L
K
D
G
E
D
L
M
D
E
S
---------
V
L
K
F
Y
T
--
Q
Q
W
E
D
Y
R
F
S
S
K
V
L
N
--
G
I
C
A
Y
L
N
R
H
W
-------------------
V
R
R
E
C
Y
E
I
Y
S
L
A
L
V
T
W
R
D
C
L
F
R
P
----
L
N
-
K
Q
V
T
N
A
V
L
K
L
I
E
K
E
R
N
G
E
T
I
N
T
R
L
--
I
S
G
V
V
Q
S
--
Y
V
E
L
G
L
-
N
--
E
D
D
A
---
F
A
K
G
-
P
T
L
T
V
Y
K
E
S
F
E
S
Q
F
L
----------------
A
--------
D
T
E
R
F
Y
T
R
E
S
T
E
F
L
Q
Q
N
-
P
V
T
E
Y
M
K
K
A
E
A
R
--
L
L
E
----
E
Q
R
R
V
Q
V
Y
---
L
H
E
S
T
Q
-----------
D
E
L
A
R
K
C
E
Q
V
L
I
-
E
K
H
L
E
I
F
H
T
E
F
Q
N
L
L
D
A
DKN
E
D
---------
L
G
R
M
Y
N
L
-----------
V
S
R
I
-----------
Q
D
G
----------
L
G
E
L
K
K
L
----
L
--
E
T
---------
H
I
----
H
N
Q
G
-
L
A
A
I
----------------
E
K
C
--
G
E
A
A
L
N
D
--
P
K
M
Y
V
Q
T
V
L
-----
D
-
V
H
K
K
Y
N
A
L
V
M
S
A
F
N
--
N
D
A
-
G
F
V
A
A
L
D
K
A
C
---
G
R
F
I
N
N
N
A
V
T
K
M
A
Q
S
S
S
K
S
P
E
------
L
L
A
R
Y
C
D
S
L
L
K
K
---------
S
S
----
K
N
-----
P
-
E
---
E
A
E
L
--
E
D
T
L
N
Q
V
M
V
V
F
K
----
Y
I
E
D
-
K
D
V
F
Q
K
-
F
----
Y
A
K
M
L
A
K
R
L
--
V
--------
H
-----------------------------------------------------------------------------------
Q
N
S
A
S
D
D
A
E
A
------
S
M
I
S
K
L
K
Q
-
A
C
--
G
F
--------------------
E
Y
T
S
K
L
Q
R
-----
M
-
F
-
Q
D
I
G
V
S
K
D
L
N
----
E
Q
F
----
K
K
H
-
L
----
T
-------------------------
N
S
E
P
L
D
L
D
--
F
S
I
Q
V
L
S
S
G
S
W
P
F
Q
Q
S
C
T
F
A
L
P
S
---------
E
--
L
E
R
S
Y
Q
----
R
F
T
----
A
F
Y
A
S
R
H
S
G
R
K
L
T
W
L
Y
Q
L
S
K
G
E
L
V
------
T
N
C
F
K
-------
N
R
Y
T
L
Q
----
A
S
T
F
Q
M
A
I
L
--
L
Q
Y
N
T
E
D
A
Y
T
V
Q
Q
L
T
D
S
T
Q
I
K
M
D
I
L
A
Q
V
L
Q
I
L
L
K
S
----
K
L
----
L
V
L
E
D
E
N
A
N
V
D
E
V
E
L
K
P
D
T
L
---
I
------
K
L
Y
L
--------
G
-
Y
K
N
K
-
K
L
R
V
-----------------------------------------------
N
---------------------------------------
I
N
V
P
M
-----------
K
T
-----------------
E
Q
K
Q
E
--------
Q
E
T
T
H
K
N
I
E
E
D
R
K
L
L
I
Q
A
A
I
V
R
I
M
K
M
R
----------
K
V
L
K
H
Q
Q
L
L
G
E
V
L
T
Q
L
S
S
R
---
F
K
P
------------
R
V
P
V
I
K
K
---
C
I
D
-
I
L
I
E
K
E
Y
L
E
R
V
D
G
E
K
D
T
Y
S
Y
L
A
------------
17
HHSearch
48.20
9%
-62
- C2 -
2IUS
-
FTSK_ECOLI
A:
[966-1210]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
G
K
D
I
A
G
E
P
V
V
--
A
D
L
A
K
-
M
P
H
L
L
V
A
G
T
T
-
G
S
G
A
S
V
G
V
N
A
M
I
L
S
M
L
Y
K
AQPE
D
V
----
R
F
I
M
I
D
P
K
M
L
E
L
S
V
Y
E
G
I
P
H
LLT
E
VVTD
M
K
D
A
A
N
--------
A
-
L
R
W
C
V
N
E
M
E
-----------------------------------------------
R
R
Y
K
L
M
S
A
L
GVRN
L
A
G
Y
N
E
K
I
A
E
A
D
R
M
MRPIPDPYWH
P
V
L
K
K
E
P
Y
-----------
I
V
-----------------
V
L
V
D
E
--------
F
A
D
L
M
M
T
V
G
K
K
V
E
E
L
I
A
R
L
A
Q
K
A
R
A
A
G
I
H
L
V
L
A
T
Q
R
P
S
V
D
--
V
-----
I
T
G
L
I
K
A
N
---
I
P
T
R
I
A
F
T
V
S
S
K
--
I
D
S
R
T
I
L
D
QAG
A
E
S
-
L
L
G
M
G
D
M
L
Y
S
G
P
N
---------------------
44
Fugue
45.07
17%
-32
- C3 -
4WID
1
?
A:
[10-362]
---------------------------------------------------------------------------------------------------
K
D
M
A
L
Q
H
A
V
D
L
L
E
K
--
M
L
A
D
E
E
K
L
T
E
F
N
L
G
--
D
P
L
F
E
S
A
N
D
D
P
----
I
K
T
L
E
E
I
I
Q
-----
E
----
G
D
D
V
V
G
A
H
Q
L
V
V
T
Q
I
K
L
R
----
V
Q
-
R
N
R
R
L
A
D
E
I
I
R
E
Q
L
T
D
I
R
K
V
F
S
D
K
--
F
E
K
L
E
Q
G
--
I
Q
N
S
Y
L
-
L
--
L
D
K
L
---
K
T
P
F
Q
D
M
R
C
L
F
E
V
--
A
N
E
Q
F
----------------
N
D
TPVPPQY
K
E
F
M
V
C
L
K
Q
I
V
Q
Y
A
V
N
S
S
S
L
E
K
F
V
M
L
I
T
------------------
K
K
D
D
I
K
D
R
V
T
-----------
Y
T
C
M
K
Y
L
L
M
A
M
Q
-
G
T
G
-
G
P
K
A
I
N
N
E
E
H
A
-----
K
L
F
FQLSNYDD
L
T
D
A
N
H
D
-----------
G
L
E
L
-----------
I
K
K
----------
L
D
K
E
Q
K
E
----
V
--
A
F
---------
H
V
----
N
N
F
T
-
H
L
V
T
----------------
T
-
L
--
G
M
A
L
Y
--------
K
---
E
-----
G
-
H
Q
K
N
D
E
A
M
L
G
------------
M
H
T
P
I
T
M
L
---
S
-----
D
Q
V
R
V
L
I
L
Y
L
I
D
E
I
V
------
H
A
I
H
T
N
S
N
Q
S
N
D
---------
E
L
----
I
D
-----
G
-
L
---
K
P
K
V
--
R
I
V
I
N
E
F
H
---
A
----
T
L
M
M
G
I
D
K
M
K
F
-
Y
----
S
L
N
E
L
R
E
I
V
--
N
--------
D
----------------------------
K
-------
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
41.34
32%
13
- C2 -
4D2I
-
?
A:
[347-434]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------------------
F
P
-
I
I
A
V
I
E
--
E
A
H
V
F
L
S
K
N
E
N
T
-
L
T
K
Y
------
W
A
S
R
I
A
R
E
-
G
R
K
F
G
V
--------------------
G
L
T
I
V
S
Q
R
-----
P
-
K
G
L
D
E
N
--
I
L
S
Q
----
M
T
N
----
K
I
I
-
L
KIIE
P
T
-
D
K
K
Y
I
L
E
----------
S
S
D
N
L
S
E
D
L
A
E
Q
L
S
--
S
L
D
V
G
E
A
I
I
I
G
K
I
V
K
L
P
A
V
V
K
I
D
---------
M
--
F
E
G
K
L
L
----
G
S
D
----
P
D
M
I
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
33.82
29%
168
- C2 -
4DFB
-
?
A:
[135-206]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
--
Q
N
Q
----
A
A
K
D
L
A
R
F
L
S
-------------------------
E
L
H
S
I
-
N
I
S
-
G
F
K
S
N
L
V
L
D
F
R
-----
E
K
---------
I
N
E
D
N
K
K
I
----------
K
K
L
L
-----------
S
R
E
----------
L
K
G
P
Q
M
K
----
K
V
D
D
F
---------
Y
R
----
D
I
L
E
-
N
E
I
Y
----------------
F
K
Y
--
Y
P
C
L
I
H
N
--
D
F
S
S
D
---
H
-----
I
-
L
F
D
T
E
K
N
T
I
C
G
I
I
D
--
F
G
D
-
A
A
I
S
D
P
D
N
D
F
---
I
S
L
M
E
E
E
Y
G
M
E
F
V
S
K
I
L
N
H
Y
K
------
H
K
D
I
P
T
V
L
E
K
Y
R
---------
M
K
----
E
K
-----
Y
-
W
---
S
F
E
K
--
I
I
Y
G
K
E
Y
G
Y
M
D
W
----
Y
E
E
G
L
N
E
I
R
S
I
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
33.35
19%
38
- C2 -
1E9R
-
?
A:
[279-345]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
-----------
L
W
-----------------
L
F
I
D
E
--------
L
A
S
L
E
K
------
L
A
S
L
A
D
A
L
T
K
G
R
K
A
G
L
R
V
V
A
G
L
Q
S
T
S
Q
L
D
D
V
Y
G
V
-
K
E
A
Q
T
L
R
A
S
---
F
R
S
L
V
V
L
G
G
S
-
R
--
T
D
P
K
T
N
E
D
---
M
S
L
-
S
L
G
E
H
E
V
E
R
D
R
A
L
E
R
V
R
E
R
V
V
M
P
A
E
---------