@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0070: (2015-12-12 )
MKIFGTDGVRGKAGVKLTPMFVMRLGIAAGLYFKKHSQTNKILIGKDTRKSGYMVENALVSALTSIGYNVIQIGPMPTPAIAFLTEDMRCDAGIMISASHNPFEDNGIKFFNSYGYKLKEEEERAIEEIFHDEELLHSSYKVGESVGSAKRIDDVIGRYIAHLKHSFPKHLNLQKLRIVLDTANGAAYKVAPVVFSELGADVLVINDEPNGCNINEQCGALHPNQLSQEVKKYRADLGFAFDGDADRLVVVDNLGNIVHGDKLLGVLGVYQKSKNALSSQAVVATSMSNLALKEYLKSQDLELKHCAIGDKFVSECMRLNKANFGGEQSGHIIFSDYAKTGDGLVCALQVSALVLESKLVSSIALNPFELYPQSLVNLNIQKKPPLESLKGYSALLKELDQLEIRHLIRYSGTENKLRILLEAKDEKLLESKMQELKEFFEGQLC
Atome Classification :
(20 SA)
.........10.-.-......20........30......-..40-........50........60........70........80........90........100.......110.......120.......130.......-140.....-..150.......160.......-.170........180.......190.......200.......210-........--220...-------.....---.230.......240.......250.......260.....--..270.......280-.......290.......300.......310.......320.......330....-...340....-...-350.....-..360......-.370.-..----....380-.--------...-.---.----.----.--.----390--.....----..----------..400.-.---..-----..-----...410.......420.......430.......440...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
I
FGTDGVRGK-A-G
V
K
L
T
P
M
F
V
M
R
L
G
I
AA
G
L
Y
F
KKHS-QT
N
K
-
I
L
I
GKDTRKSG
Y
M
V
E
N
A
L
V
S
A
L
T
S
IG
Y
N
V
I
Q
IGPMP
T
P
A
I
A
F
L
TEDMRCDA
G
I
M
I
SASHNPFEDNG
I
K
F
F
N
SYGYKL
K
E
E
E
E
R
A
I
E
E
I
F
H
D
E
E
L
L
H
S
S
-YKV
G
E
SVG-S
A
K
R
I
D
D
V
I
G
R
Y
I
-
A
H
L
K
H
S
F
P
-KHL-N
L
Q
K
L
R
I
V
L
DTANGA
A
Y
K
V
A
P
V
V
F
S
ELGA
D
V
L
V
INDEPNG--CNI
N
E
Q
CG--A--L
H
P
-------
N
Q
L
S
Q
---
E
V
K
K
Y
R
A
DLGFAFDGDA
D
R
L
V
V
VDNLGNIVH
G
D
K
L
L
G
V
L
--
G
V
Y
Q
K
S
KNALSSQA
V
-
V
A
T
S
M
S
N
L
A
L
K
E
Y
L
K
SQDLE
L
K
H
CAI
G
D
K
F
V
S
E
C
M
R
LNKANFGGEQS
G
H
I
I
F
SD-YAKTGD
G
L
V
C
-
A
L
Q
-
V
S
A
L
V
L
E
S
-
K
L
V
S
S
IAL
N
P
F
-
E
L
Y
P
Q
-
S
L
----VNLNI---Q--------KKP-
P
---
L
----
E
----
S
--
L
----
K
----
G
Y
S
A
L
----
L
K
----------
E
L
D
--
Q
-
L
---
E
I
-----
R
H
-----
L
I
RYSGTE
N
K
L
R
I
L
L
EAK
D
E
K
L
L
E
S
K
M
Q
E
L
K
E
F
FEGQLC
27
HHSearch
94.19
38%
-87
- C1 -
3PDK
3
GLMM_BACAN
A:
[23-466]
G
K
Y
F
G
T
D
G
V
R
G
V
-
A
-
N
K
E
L
T
P
E
L
A
F
K
I
G
R
F
G
G
Y
V
L
T
K
D
T
-
D
R
P
K
-
V
I
I
G
R
D
T
R
I
S
G
H
M
L
E
G
A
L
V
A
G
L
L
S
T
G
A
E
V
M
R
L
G
V
I
S
T
P
G
V
A
Y
L
T
K
A
L
D
A
Q
A
G
V
M
I
S
A
S
H
N
P
V
Q
D
N
G
I
K
F
F
G
S
D
G
F
K
L
T
D
E
Q
E
A
E
I
E
A
L
L
D
K
E
V
D
-
E
L
P
-
R
P
T
G
T
N
L
G
-
Q
V
S
D
Y
F
E
G
G
Q
K
Y
L
-
Q
Y
I
K
Q
T
V
E
-
E
---
D
F
S
G
L
H
I
A
L
D
C
A
H
G
A
T
S
S
L
A
P
Y
L
F
A
D
L
E
A
D
I
S
T
M
G
T
S
P
N
G
--
M
N
I
N
D
G
V
G
--
S
--
T
H
P
-------
E
V
L
A
E
---
L
V
K
E
K
G
A
D
I
G
L
A
F
D
G
D
G
D
R
L
I
A
V
D
E
K
G
N
I
V
D
G
D
Q
I
M
F
I
C
--
A
K
Y
M
K
E
T
G
Q
L
K
H
N
T
V
-
V
S
T
V
M
S
N
L
G
F
Y
K
A
L
E
A
N
G
I
T
S
D
K
T
A
V
G
D
R
Y
V
M
E
E
M
K
R
G
G
Y
N
L
G
G
E
Q
S
G
H
I
I
L
L
D
-
Y
I
T
T
G
D
G
M
L
S
-
A
L
Q
-
L
V
N
I
M
K
M
T
-
K
K
P
L
S
E
L
A
G
E
M
-
T
K
F
P
Q
-
L
L
----
V
N
V
R
V
---
T
--------
D
K
K
-
L
---
A
----
L
----
E
--
N
----
E
----
K
I
K
E
I
----
I
R
----------
V
V
E
E
E
M
N
G
---
D
G
-----
R
I
-----
L
V
R
P
S
G
T
E
P
L
I
R
V
M
A
E
A
P
T
Q
E
V
C
D
A
Y
V
H
R
I
V
E
V
V
K
A
E
V
G
1
PsiBlast_PDB
94.18
39%
-87
- C1 -
3PDK
3
GLMM_BACAN
A:
[24-466]
-
K
Y
F
G
T
D
G
V
R
G
V
-
A
-
N
K
E
L
T
P
E
L
A
F
K
I
G
R
F
G
G
Y
V
L
T
K
D
T
-
D
R
P
K
-
V
I
I
G
R
D
T
R
I
S
G
H
M
L
E
G
A
L
V
A
G
L
L
S
T
G
A
E
V
M
R
L
G
V
I
S
T
P
G
V
A
Y
L
T
K
A
L
D
A
Q
A
G
V
M
I
S
A
S
H
N
P
V
Q
D
N
G
I
K
F
F
G
S
D
G
F
K
L
T
D
E
Q
E
A
E
I
E
A
L
L
-
D
K
E
V
D
E
L
P
-
R
P
T
G
T
N
L
G
-
Q
V
S
D
Y
F
E
G
G
Q
K
Y
L
-
Q
Y
I
K
Q
T
V
E
-
E
---
D
F
S
G
L
H
I
A
L
D
C
A
H
G
A
T
S
S
L
A
P
Y
L
F
A
D
L
E
A
D
I
S
T
M
G
T
S
P
N
G
--
M
N
I
N
D
G
V
G
--
S
--
T
H
P
-------
E
V
L
A
E
---
L
V
K
E
K
G
A
D
I
G
L
A
F
D
G
D
G
D
R
L
I
A
V
D
E
K
G
N
I
V
D
G
D
Q
I
M
F
I
C
--
A
K
Y
M
K
E
T
G
Q
L
K
H
N
T
V
-
V
S
T
V
M
S
N
L
G
F
Y
K
A
L
E
A
N
G
I
T
S
D
K
T
A
V
G
D
R
Y
V
M
E
E
M
K
R
G
G
Y
N
L
G
G
E
Q
S
G
H
I
I
L
L
D
-
Y
I
T
T
G
D
G
M
L
S
-
A
L
Q
L
V
N
I
M
K
M
T
K
-
K
P
L
S
E
L
A
-
G
E
M
-
T
K
F
P
Q
-
L
L
----
V
N
V
R
V
T--
D
--------
K
K
L
-
A
---
L
----
E
----
N
E
K
I
----
K
----
E
I
I
R
V
----
V
E
----------
E
E
M
--
N
-
G
---
D
G
-----
R
I
-----
L
V
R
P
S
G
T
E
P
L
I
R
V
M
A
E
A
P
T
Q
E
V
C
D
A
Y
V
H
R
I
V
E
V
V
K
A
E
V
G
21
PsiBlast_CBE
93.42
39%
-86
- C1 -
3PDK
5
GLMM_BACAN
B:
[24-466]
-
K
Y
F
G
T
D
G
V
R
G
V
-
A
-
N
K
E
L
T
P
E
L
A
F
K
I
G
R
F
G
G
Y
V
L
T
K
D
T
-
D
R
P
K
-
V
I
I
G
R
D
T
R
I
S
G
H
M
L
E
G
A
L
V
A
G
L
L
S
T
G
A
E
V
M
R
L
G
V
I
S
T
P
G
V
A
Y
L
T
K
A
L
D
A
Q
A
G
V
M
I
S
A
S
H
N
P
V
Q
D
N
G
I
K
F
F
G
S
D
G
F
K
L
T
D
E
Q
E
A
E
I
E
A
L
L
-
D
K
E
V
D
E
L
P
-
R
P
T
G
T
N
L
G
-
Q
V
S
D
Y
F
E
G
G
Q
K
Y
L
-
Q
Y
I
K
Q
T
V
E
-
E
---
D
F
S
G
L
H
I
A
L
D
C
A
H
G
A
T
S
S
L
A
P
Y
L
F
A
D
L
E
A
D
I
S
T
M
G
T
S
P
N
G
--
M
N
I
N
D
G
V
G
--
S
--
T
H
P
-------
E
V
L
A
E
---
L
V
K
E
K
G
A
D
I
G
L
A
F
D
G
D
G
D
R
L
I
A
V
D
E
K
G
N
I
V
D
G
D
Q
I
M
F
I
C
--
A
K
Y
M
K
E
T
G
Q
L
K
H
N
T
V
-
V
S
T
V
M
S
N
L
G
F
Y
K
A
L
E
A
N
G
I
T
S
D
K
T
A
V
G
D
R
Y
V
M
E
E
M
K
R
G
G
Y
N
L
G
G
E
Q
S
G
H
I
I
L
L
D
-
Y
I
T
T
G
D
G
M
L
S
-
A
L
Q
L
V
N
I
M
K
M
T
K
-
K
P
L
S
E
L
A
-
G
E
M
-
T
K
F
P
Q
-
L
L
----
V
N
V
R
V
T--
D
--------
K
K
L
-
A
---
L
----
E
----
N
EK
I
----
K
----
E
I
I
R
V
----
V
E
----------
E
E
M
--
N
-
G
---
D
G
-----
R
I
-----
L
V
R
P
S
G
T
E
P
L
I
R
V
M
A
E
A
P
T
Q
E
V
C
D
A
Y
V
H
R
I
V
E
V
V
K
A
E
V
G
2
PsiBlast_PDB
92.52
34%
-93
- C1 -
3I3W
1
GLMM_FRATT
A:
[3-436]
-
K
Y
F
G
T
D
G
I
R
G
E
V
A
-
N
S
T
I
T
V
E
F
T
Q
K
L
G
N
A
V
G
S
L
I
N
Q
K
N
-
Y
P
K
F
-
V
I
V
G
Q
D
T
R
S
S
G
G
F
L
K
F
A
L
V
S
G
L
N
A
A
G
I
D
V
L
D
L
G
V
V
P
T
P
V
V
A
F
M
T
V
K
H
R
A
A
A
G
F
V
I
T
A
S
H
N
K
F
T
D
N
G
I
K
L
F
S
S
N
G
F
K
L
D
D
A
L
E
E
E
V
E
D
M
I
D
G
D
F
I
Y
Q
P
Q
-
F
K
----
F
G
-
S
Y
K
I
L
A
N
A
I
D
E
Y
I
-
E
S
I
Y
S
R
F
A
-
K
F
V
-
N
Y
-
K
G
K
V
V
V
D
C
A
H
G
A
A
S
H
N
F
E
A
L
L
D
K
F
G
I
N
Y
V
S
I
A
S
N
P
D
G
--
L
N
I
N
V
G
C
G
--
A
--
T
C
V
-------
S
N
I
K
K
---
A
V
K
E
Q
K
A
D
L
G
I
S
L
D
G
D
A
D
R
I
I
I
V
D
E
N
G
Q
E
I
D
G
D
G
I
L
N
I
L
--
A
Q
Y
--
S
D
I
C
G
G
T
N
G
I
-
V
G
T
Q
M
T
N
M
S
Y
E
N
H
Y
R
A
N
K
I
P
F
I
R
S
K
V
G
D
R
Y
V
L
E
D
L
V
K
Y
G
Y
K
I
G
G
E
S
S
G
H
V
I
N
L
N
-
F
G
T
T
G
D
G
L
F
T
-
A
I
Q
-
L
L
A
I
F
S
Q
A
D
K
P
V
S
E
F
K
L
Q
G
--
E
L
M
Q
Q
-
T
L
----
I
N
V
P
L
---
T
--------
K
K
V
-
A
---
R
----
E
----
D
--
L
----
Q
----
K
V
A
S
D
----
V
N
----------
D
V
E
--
K
-
R
LGN
R
G
-----
R
V
-----
L
L
R
P
S
G
T
E
P
V
L
R
V
M
V
E
A
D
D
K
S
L
A
T
N
E
A
E
Y
L
V
E
K
V
K
Q
K
L
V
30
HHSearch
89.48
34%
-83
- C1 -
3I3W
1
GLMM_FRATT
A:
[3-442]
-
K
Y
F
G
T
D
G
I
R
G
E
-
V
A
N
S
T
I
T
V
E
F
T
Q
K
L
G
N
A
V
G
S
L
I
N
Q
K
N
-
Y
P
K
F
-
V
I
V
G
Q
D
T
R
S
S
G
G
F
L
K
F
A
L
V
S
G
L
N
A
A
G
I
D
V
L
D
L
G
V
V
P
T
P
V
V
A
F
M
T
V
K
H
R
A
A
A
G
F
V
I
T
A
S
H
N
K
F
T
D
N
G
I
K
L
F
S
S
N
G
F
K
L
D
D
A
L
E
E
E
V
E
D
M
I
D
G
D
----
F
I
-
Y
Q
P
Q
F
K
F
G
-
S
Y
K
I
L
A
N
A
I
D
E
Y
I
-
E
S
I
Y
S
R
F
A
-
K
-
F
-
V
N
Y
K
G
K
V
V
V
D
C
A
H
G
A
A
S
H
N
F
E
A
L
L
D
K
F
G
I
N
Y
V
S
I
A
S
N
P
D
G
--
L
N
I
N
V
G
C
G
--
A
--
T
C
V
-------
S
N
I
K
K
---
A
V
K
E
Q
K
A
D
L
G
I
S
L
D
G
D
A
D
R
I
I
I
V
D
E
N
G
Q
E
I
D
G
D
G
I
L
N
I
L
--
A
Q
Y
S
D
I
C
G
--
G
T
N
G
I
-
V
G
T
Q
M
T
N
M
S
Y
E
N
H
Y
R
A
N
K
I
P
F
I
R
S
K
V
G
D
R
Y
V
L
E
D
L
V
K
Y
G
Y
K
I
G
G
E
S
S
G
H
V
I
N
L
N
-
F
G
T
T
G
D
G
L
F
T
-
A
I
Q
-
L
L
A
I
F
S
Q
A
-
D
K
P
V
S
E
F
K
L
Q
G
-
E
L
M
Q
Q
-
T
L
----
I
N
--
V
---
P
--------
L
T
K
-
K
---
V
----
A
R
E
--
D
--
L
----
Q
----
K
V
A
S
D
----
V
N
----------
D
V
E
K
R
L
G
N
---
R
G
-----
R
V
-----
L
L
R
P
S
G
T
E
P
V
L
R
V
M
V
E
A
D
D
K
S
L
A
T
N
E
A
E
Y
L
V
E
K
V
K
Q
K
L
V
4
PsiBlast_PDB
87.04
30%
-81
- C1 -
2F7L
1
?
A:
[3-455]
-
K
L
F
G
T
D
G
V
R
G
I
-
V
-
N
K
E
L
T
P
E
L
V
L
K
L
S
K
A
I
G
T
F
F
G
K
N
S
----
K
-
I
L
V
G
R
D
V
R
A
G
G
D
M
L
V
K
I
V
E
G
G
L
L
S
V
G
V
E
V
Y
D
G
G
M
A
P
T
P
A
L
Q
Y
A
V
K
T
L
G
Y
D
G
G
V
V
I
T
A
S
H
N
P
A
P
Y
N
G
I
K
V
V
D
K
D
G
I
E
I
R
R
E
K
E
N
E
I
E
D
L
F
F
T
E
R
F
--
N
T
-
I
E
W
S
S
L
T
T
-
E
V
K
R
E
D
R
V
I
S
T
Y
V
N
G
I
L
S
H
V
D
I
-
E
K
I
-
K
K
K
N
Y
K
V
L
I
D
P
A
N
S
V
G
A
L
S
T
P
L
V
A
R
A
L
G
C
K
I
Y
T
I
N
-------
G
N
L
D
P
L
F
S
--
A
--
R
Q
P
EPTFDSL
K
E
T
A
E
---
V
V
K
T
L
K
V
D
L
G
V
A
H
D
G
D
A
D
R
A
I
F
I
D
S
E
G
R
V
Q
W
G
D
R
S
G
T
L
L
--
S
Y
W
A
S
V
K
N
P
K
A
I
K
K
I
-
V
T
A
V
S
S
S
S
L
V
E
E
Y
L
S
K
Y
N
I
Q
V
D
W
T
K
V
G
S
V
D
I
A
H
K
V
A
D
E
N
A
L
A
G
F
E
E
N
G
G
F
M
Y
P
P
-
H
Q
Y
V
R
D
G
A
M
S
F
A
L
M
-
L
E
L
L
A
N
E
N
---
V
S
S
A
E
L
--
F
-
D
R
L
P
K
Y
Y
L
----
V
K
T
K
V
---
D
--------
L
K
P
-
G
---
L
----
M
----
V
--
E
----
E
----
I
Y
K
K
I
----
L
E
V
YSTSS
V
K
A
I
T
I
D
--
G
-
V
---
K
I
I
G
KD
F
W
F
-----
L
V
R
K
S
G
T
E
P
I
I
R
I
M
A
E
A
K
D
E
N
V
A
N
N
L
V
N
E
L
K
K
I
V
E
G
K
--
23
PsiBlast_CBE
85.78
32%
-74
- C1 -
1WQA
1
?
C:
[3-434]
-
K
L
F
G
T
F
G
V
R
G
I
-
A
-
N
E
K
I
T
P
E
F
A
M
K
I
G
M
A
F
G
T
L
L
K
R
E
G
-
R
K
K
P
L
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
E
A
I
V
E
E
L
F
F
K
E
D
F
D
R
A
K
W
Y
E
I
G
E
V
------
R
R
E
D
I
I
K
P
Y
I
-
E
A
I
K
S
K
V
D
V
E
A
I
-
K
K
R
K
P
F
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
YF
P
A
R
N
P
E
P
N
--
E
--
E
N
L
-------
K
E
F
M
E
---
I
V
K
A
L
G
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
AD
A
V
L
K
E
K
G
G
G
L
---
L
V
-
T
T
V
A
T
S
N
L
-
L
D
D
I
A
K
K
H
G
A
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
-
H
V
L
G
R
D
G
A
M
T
-
V
A
K
-
V
V
E
I
F
A
K
S
-
G
K
K
F
S
E
L
I
D
E
L
-
P
K
Y
Y
Q
-
I
K
----
T
K
R
H
V
---
E
GDRHAIVN
K
V
A
-
E
---
M
----
A
----
R
--
E
----
R
----
G
Y
T
V
D
----
T
T
----------
D
G
A
--
K
-
I
---
I
F
-----
E
D
GWV--
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
L
N
L
G
I
E
L
L
E
K
A
L
S
3
PsiBlast_PDB
85.76
32%
-74
- C1 -
1WQA
1
?
A:
[3-434]
-
K
L
F
G
T
F
G
V
R
G
I
-
A
-
N
E
K
I
T
P
E
F
A
M
K
I
G
M
A
F
G
T
L
L
K
R
E
G
-
R
K
K
P
L
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
E
A
I
V
E
E
L
F
F
K
E
D
F
D
R
A
K
W
Y
E
I
G
E
V
------
R
R
E
D
I
I
K
P
Y
I
-
E
A
I
K
S
K
V
D
V
E
A
I
-
K
K
R
K
P
F
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
YF
P
A
R
N
P
E
P
N
--
E
--
E
N
L
-------
K
E
F
M
E
---
I
V
K
A
L
G
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
A
D
A
V
L
K
E
K
G
G
G
L
---
L
V
-
T
T
V
A
T
S
N
L
-
L
D
D
I
A
K
K
H
G
A
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
-
H
V
L
G
R
D
G
A
M
T
-
V
A
K
-
V
V
E
I
F
A
K
S
-
G
K
K
F
S
E
L
I
D
E
L
-
P
K
Y
Y
Q
-
I
K
----
T
K
R
H
V
---
E
G
D
R
H
A
I
V
N
K
V
A
-
E
---
M
----
A
----
R
--
E
----
R
----
G
Y
T
V
D
----
T
T
----------
D
G
A
--
K
-
I
---
I
F
-----
E
D
G
W
V
--
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
L
N
L
G
I
E
L
L
E
K
A
L
S
24
PsiBlast_CBE
85.73
32%
-75
- C1 -
1WQA
1
?
B:
[3-434]
-
K
L
F
G
T
F
G
V
R
G
I
-
A
-
N
E
K
I
T
P
E
F
A
M
K
I
G
M
A
F
G
T
L
L
K
R
E
G
-
R
K
K
P
L
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
E
A
I
V
E
E
L
F
F
K
E
D
F
D
R
A
K
W
Y
E
I
G
E
V
------
R
R
E
D
I
I
K
P
Y
I
-
E
A
I
K
S
K
V
D
V
E
A
I
-
K
K
R
K
P
F
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
YF
P
A
R
N
P
E
P
N
--
E
--
E
N
L
-------
K
E
F
M
E
---
I
V
K
A
L
G
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
AD
A
V
L
K
E
K
G
G
G
L
---
L
V
-
T
T
V
A
T
S
N
L
-
L
D
D
I
A
K
K
H
G
A
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
-
H
V
L
G
R
D
G
A
M
T
-
V
A
K
-
V
V
E
I
F
A
K
S
-
G
K
K
F
S
E
L
I
D
E
L
-
P
K
Y
Y
Q
-
I
K
----
T
K
R
H
V
---
E
GDRHAIVN
K
V
A
-
E
---
M
----
A
----
R
--
E
----
R
----
G
Y
T
V
D
----
T
T
----------
D
G
A
--
K
-
I
---
I
F
-----
E
D
GWV--
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
L
N
L
G
I
E
L
L
E
K
A
L
S
22
PsiBlast_CBE
85.20
32%
-74
- C1 -
1WQA
1
?
D:
[3-434]
-
K
L
F
G
T
F
G
V
R
G
I
-
A
-
N
E
K
I
T
P
E
F
A
M
K
I
G
M
A
F
G
T
L
L
K
R
E
G
-
R
K
K
P
L
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
E
A
I
V
E
E
L
F
F
K
E
D
F
D
R
A
K
W
Y
E
I
G
E
V
------
R
R
E
D
I
I
K
P
Y
I
-
E
A
I
K
S
K
V
D
V
E
A
I
-
K
K
R
K
P
F
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
YF
P
A
R
N
P
E
P
N
--
E
--
E
N
L
-------
K
E
F
M
E
---
I
V
K
A
L
G
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
AD
A
V
L
K
E
K
G
G
G
L
---
L
V
-
T
T
V
A
T
S
N
L
-
L
D
D
I
A
K
K
H
G
A
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
-
H
V
L
G
R
D
G
A
M
T
-
V
A
K
-
V
V
E
I
F
A
K
S
-
G
K
K
F
S
E
L
I
D
E
L
-
P
K
Y
Y
Q
-
I
K
----
T
K
R
H
V
---
E
GDRHAIVN
K
V
A
-
E
---
M
----
A
----
R
--
E
----
R
----
G
Y
T
V
D
----
T
T
----------
D
G
A
--
K
-
I
---
I
F
-----
E
D
GWV--
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
L
N
L
G
I
E
L
L
E
K
A
L
S
29
HHSearch
84.61
31%
-61
* C1 *
1WQA
1
?
A:
[2-454]
G
K
L
F
G
T
F
G
V
R
G
I
-
A
-
N
E
K
I
T
P
E
F
A
M
K
I
G
M
A
F
G
T
L
L
K
R
E
G
R
K
K
P
L
-
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
E
A
I
V
E
E
L
F
F
K
E
D
---
F
D
-
R
A
K
W
Y
E
I
G
-
E
V
R
R
-
E
D
I
I
K
P
Y
I
-
E
A
I
K
S
K
V
D
-
V
E
A
I
K
K
R
K
P
F
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
--
Y
F
P
A
R
N
P
E
PN
E
--
E
N
L
-------
K
E
F
M
E
---
I
V
K
A
L
G
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
--
A
D
A
V
L
K
E
K
--
G
G
G
L
L
-
V
T
T
V
A
T
S
N
L
L
D
D
I
A
K
K
H
G
A
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
-
H
V
L
G
R
D
G
A
M
T
-
V
A
K
-
V
V
E
I
F
A
K
S
-
G
K
K
F
S
E
L
I
D
E
L
-
P
K
Y
Y
Q
-
I
K
----
T
K
R
H
V
---
E
--------
G
D
R
H
A
---
I
V
N
K
V
A
----
E
--
M
----
A
R
E
R
G
Y
T
V
D
T
----
T
D
----------
G
A
K
I
I
F
-
E
---
D
G
-----
W
V
-----
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
L
N
L
G
I
E
L
L
E
K
A
L
S
6
PsiBlast_PDB
82.45
25%
-73
- C1 -
1K2Y
2
ALGC_PSEAE
X:
[13-452]
--
I
F
R
A
Y
D
I
R
G
V
-
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
G
-
E
P
C
--
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
A
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
L
--------
A
S
G
V
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
-
K
Q
I
R
D
D
I
A
-
M
A
----
K
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
--
N
F
P
N
H
H
P
D
--
P
--
G
K
P
-------
E
N
L
K
D
LIA
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
--
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
---
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
-
A
A
R
-
L
L
E
I
L
S
Q
D
-
Q
R
D
S
E
---
H
V
F
-
S
A
F
P
S
-
D
I
STPE
I
N
I
T
V
TED
S
--------
K
F
A
-
I
---
I
----
E
----
A
--
L
----
Q
----
R
D
A
Q
W
GEGN
I
T
----------
T
L
D
--
G
-
V
---
R
V
-----
D
Y
PKGWG
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
5
PsiBlast_PDB
82.30
26%
-68
- C1 -
4MRQ
13
ALGC_PSEAE
A:
[5-444]
--
I
F
R
A
Y
D
I
R
G
V
-
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
G
-
E
P
C
--
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
L
--------
A
S
G
V
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
-
K
Q
I
R
D
D
I
A
-
M
A
----
K
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
--
N
F
P
N
H
H
P
D
--
P
--
G
K
P
-------
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
--
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
---
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
-
A
A
R
-
L
L
E
I
L
S
Q
D
-
Q
R
D
S
E
---
H
V
F
-
S
A
F
P
S
-
D
I
STP
E
I
N
I
T
V
T
ED
S
--------
K
F
A
-
I
---
I
----
E
----
A
--
L
----
Q
----
R
D
A
Q
W
GEGN
I
T
----------
T
L
D
--
G
-
V
---
R
V
-----
D
Y
PK
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
28
HHSearch
82.03
28%
-73
- C1 -
2F7L
1
?
A:
[2-454]
G
K
L
F
G
T
D
G
V
R
G
I
-
V
-
N
K
E
L
T
P
E
L
V
L
K
L
S
K
A
I
G
T
F
F
G
K
N
----
S
K
-
I
L
V
G
R
D
V
R
A
G
G
D
M
L
V
K
I
V
E
G
G
L
L
S
V
G
V
E
V
Y
D
G
G
M
A
P
T
P
A
L
Q
Y
A
V
K
T
L
G
Y
D
G
G
V
V
I
T
A
S
H
N
P
A
P
Y
N
G
I
K
V
V
D
K
D
G
I
E
I
R
R
E
K
E
N
E
I
E
D
L
F
F
T
E
R
---
F
N
-
T
I
E
W
S
S
L
T
T
E
V
K
R
E
D
R
V
I
S
T
Y
V
-
N
G
I
L
S
H
V
D
-
I
E
K
I
K
K
K
N
Y
K
V
L
I
D
P
A
N
S
V
G
A
L
S
T
P
L
V
A
R
A
L
G
C
K
I
Y
T
I
N
G
N
L
D
P
--
L
F
S
A
R
Q
P
E
--
P
TF
D
S
L
-------
K
E
T
A
E
---
V
V
K
T
L
K
V
D
L
G
V
A
H
D
G
D
A
D
R
A
I
F
I
D
S
E
G
R
V
Q
W
G
D
R
S
G
T
L
L
--
S
Y
W
A
S
V
K
N
P
K
A
I
K
K
I
-
V
T
A
V
S
S
S
S
L
V
E
E
Y
L
S
K
Y
N
I
Q
V
D
W
T
K
V
G
S
V
D
I
A
H
K
V
A
D
E
N
A
L
A
G
F
E
E
N
G
G
F
M
Y
P
P
-
H
Q
Y
V
R
D
G
A
M
S
-
F
A
L
-
M
L
E
L
L
A
N
E
-
N
V
S
S
A
E
L
F
D
R
L
-
P
K
Y
Y
L
-
V
K
----
T
K
V
D
L
---
K
--------
P
G
L
-
M
V
E
E
I
----
Y
K
K
I
L
E
--
V
YSTS
S
----
V
K
A
I
T
----
I
D
----------
G
V
K
I
I
G
-
K
---
D
F
-----
W
F
-----
L
V
R
K
S
G
T
E
P
I
I
R
I
M
A
E
A
K
D
E
N
V
A
N
N
L
V
N
E
L
K
K
I
V
E
G
K
--
8
PsiBlast_PDB
81.66
25%
-68
- C1 -
1P5D
2
ALGC_PSEAE
X:
[13-452]
--
I
F
R
A
Y
D
I
R
G
V
-
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
G
-
E
P
C
--
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
L
--------
A
S
G
V
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
-
K
Q
I
R
D
D
I
A
-
M
A
----
K
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
--
N
F
P
N
H
H
P
D
--
P
--
G
K
P
-------
E
N
L
K
D
LIA
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
--
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
---
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
-
A
A
R
-
L
L
E
I
L
S
Q
D
-
Q
R
D
S
E
---
H
V
F
-
S
A
F
P
S
-
D
I
STPE
I
N
I
T
V
TED
S
--------
K
F
A
-
I
---
I
----
E
----
A
--
L
----
Q
----
R
D
A
Q
W
GEGN
I
T
----------
T
L
D
--
G
-
V
---
R
V
-----
D
Y
PKGWG
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
18
PsiBlast_PDB
81.54
25%
-70
- C1 -
1K35
1
ALGC_PSEAE
A:
[13-452]
--
I
F
R
A
Y
D
I
R
G
V
-
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
G
-
E
P
C
--
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
L
--------
A
S
G
V
G
-
S
V
E
Q
V
D
-
I
L
P
R
Y
F
-
K
Q
I
R
D
D
I
----
A
-
M
A
K
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
--
N
F
P
N
H
H
P
D
--
P
--
G
K
P
-------
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
--
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
---
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
-
A
A
R
-
L
L
E
I
L
S
Q
D
-
Q
R
D
S
E
---
H
V
F
-
S
A
F
P
S
-
D
I
S
T
P
E
I
N
I
T
V
TED
S
--------
K
F
A
-
I
---
I
----
E
----
A
--
L
----
Q
----
R
D
A
Q
W
GEGN
I
T
----------
T
L
D
--
G
-
V
---
R
V
-----
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
16
PsiBlast_PDB
81.43
25%
-70
- C1 -
3C04
1
ALGC_PSEAE
A:
[13-452]
--
I
F
R
A
Y
D
I
R
G
V
-
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
G
-
E
P
C
--
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
L
--------
A
S
G
V
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
-
K
Q
I
R
D
D
I
A
-
M
A
----
K
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
--
N
F
P
N
H
H
P
D
--
P
--
G
K
P
-------
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
--
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
---
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
-
A
A
R
-
L
L
E
I
L
S
Q
D
-
Q
R
D
S
E
H
V
F
S
A
F
G
S
D
I
S
T
-
P
E
----
I
N
I
T
V
TED
S
--------
K
F
A
-
I
---
I
----
E
----
A
--
L
----
Q
----
R
D
A
Q
W
GEGN
I
T
----------
T
L
D
--
G
-
V
---
R
V
-----
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
11
PsiBlast_PDB
81.43
25%
-68
- C1 -
1PCM
2
ALGC_PSEAE
X:
[13-452]
--
I
F
R
A
Y
D
I
R
G
V
-
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
G
-
E
P
C
--
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
L
--------
A
S
G
V
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
-
K
Q
I
R
D
D
I
A
-
M
A
----
K
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
--
N
F
P
N
H
H
P
D
--
P
--
G
K
P
-------
E
N
L
K
D
LIA
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
--
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
---
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
-
A
A
R
-
L
L
E
I
L
S
Q
D
-
Q
R
D
S
E
---
H
V
F
-
S
A
F
P
S
-
D
I
STPE
I
N
I
T
V
TED
S
--------
K
F
A
-
I
---
I
----
E
----
A
--
L
----
Q
----
R
D
A
Q
W
GEGN
I
T
----------
T
L
D
--
G
-
V
---
R
V
-----
D
Y
PKGWG
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
13
PsiBlast_PDB
81.37
25%
-69
- C1 -
2H5A
2
ALGC_PSEAE
X:
[13-452]
--
I
F
R
A
Y
D
I
R
G
V
-
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
G
-
E
P
C
--
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
L
--------
A
S
G
V
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
-
K
Q
I
R
D
D
I
A
-
M
A
----
K
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
--
N
F
P
N
H
H
P
D
--
P
--
G
K
P
-------
E
N
L
K
D
LIA
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
--
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
---
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
-
A
A
R
-
L
L
E
I
L
S
Q
D
-
Q
R
D
S
E
---
H
V
F
-
S
A
F
P
S
-
D
I
STPE
I
N
I
T
V
TED
S
--------
K
F
A
-
I
---
I
----
E
----
A
--
L
----
Q
----
R
D
A
Q
W
GEGN
I
T
----------
T
L
D
--
G
-
V
---
R
V
-----
D
Y
PKGWG
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
9
PsiBlast_PDB
81.24
25%
-68
- C1 -
1P5G
2
ALGC_PSEAE
X:
[13-452]
--
I
F
R
A
Y
D
I
R
G
V
-
V
-
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
G
-
E
P
C
--
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
K
N
D
L
--------
A
S
G
V
G
-
S
V
E
Q
V
-
D
I
L
P
R
Y
F
-
K
Q
I
R
D
D
I
A
-
M
A
----
K
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
--
N
F
P
N
H
H
P
D
--
P
--
G
K
P
-------
E
N
L
K
D
LIA
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
--
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
---
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
-
A
A
R
-
L
L
E
I
L
S
Q
D
-
Q
R
D
S
E
---
H
V
F
-
S
A
F
P
S
-
D
I
STPE
I
N
I
T
V
TED
S
--------
K
F
A
-
I
---
I
----
E
----
A
--
L
----
Q
----
R
D
A
Q
W
GEGN
I
T
----------
T
L
D
--
G
-
V
---
R
V
-----
D
Y
PKGWG
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K